| a body tracking-based low-cost solution for monitoring workers' hygiene best practices during pandemics. | since its beginning at the end of 2019, the pandemic spread of the severe acute respiratory syndrome coronavirus 2 (sars-cov-2) caused more than one million deaths in only nine months. the threat of emerging and re-emerging infectious diseases exists as an imminent threat to human health. it is essential to implement adequate hygiene best practices to break the contagion chain and enhance society preparedness for such critical scenarios and understand the relevance of each disease transmission r ... | 2020 | 33138092 |
| molecular insights into human transmembrane protease serine-2 (tmps2) inhibitors against sars-cov2: homology modelling, molecular dynamics, and docking studies. | the severe acute respiratory syndrome coronavirus 2 (sars-cov2), which caused novel corona virus disease-2019 (covid-19) pandemic, necessitated a global demand for studies related to genes and enzymes of sars-cov2. sars-cov2 infection depends on the host cell angiotensin-converting enzyme-2 (ace2) and transmembrane serine protease-2 (tmprss2), where the virus uses ace2 for entry and tmprss2 for s protein priming. the tmprss2 gene encodes a transmembrane protease serine-2 protein (tmps2) that bel ... | 2020 | 33137894 |
| interaction of small molecules with the sars-cov-2 main protease in silico and in vitro validation of potential lead compounds using an enzyme-linked immunosorbent assay. | caused by the severe acute respiratory syndrome coronavirus 2 (sars-cov-2), the covid-19 pandemic is ongoing, with no proven safe and effective vaccine to date. further, effective therapeutic agents for covid-19 are limited, and as a result, the identification of potential small molecule antiviral drugs is of particular importance. a critical antiviral target is the sars-cov-2 main protease (mpro), and our aim was to identify lead compounds with potential inhibitory effects. we performed an init ... | 2020 | 33137690 |
| evaluation of mechanisms of action of re-purposed drugs for treatment of covid-19. | coronavirus disease 2019 (covid-19) is a global health emergency caused by severe acute respiratory syndrome coronavirus 2 (sars-cov-2). the rapid worldwide spread of sars-cov-2 infection has necessitated a global effort to identify effective therapeutic strategies in the absence of vaccine. among the re-purposed drugs being tested currently, hydroxychloroquine (hcq), without or with zinc ion (zn++) and the antibiotic azithromycin (azm), has been administered to prevent or treat patients with co ... | 2020 | 33137649 |
| covid-19 and major organ thromboembolism: manifestations in neurovascular and cardiovascular systems. | covid-19, caused by the severe acute respiratory syndrome coronavirus 2 (sars-cov-2), has been shown to cause multisystemic damage. we undertook a systematic literature review and comprehensive analysis of a total of 55 articles on arterial and venous thromboembolism in covid-19 and articles on previous pandemics with respect to thromboembolism and compared the similarities and differences between them. the presence of thrombosis in multiple organ systems points to thromboembolism being an integ ... | 2020 | 33137615 |
| aging in covid-19: vulnerability, immunity and intervention. | the severe acute respiratory syndrome coronavirus-2 (sars-cov-2) pandemic was first reported in wuhan, china in december 2019, moved across the globe at an unprecedented speed, and has caused a profound and yet still unfolding health and socioeconomic impacts. sars-cov-2, a β-coronavirus, is a highly contagious respiratory pathogen that causes a disease that has been termed the 2019 coronavirus disease (covid-19). clinical experience thus far indicates that covid-19 is highly heterogeneous, rang ... | 2020 | 33137510 |
| frequency of venous thromboembolism in 6513 patients with covid-19: a retrospective study. | patients infected with severe acute respiratory syndrome coronavirus 2 (sars-cov-2) appear to be at increased risk for venous thromboembolism (vte), especially if they become critically ill with covid-19. some centers have reported very high rates of thrombosis despite anticoagulant prophylaxis. the electronic health record (ehr) of a new orleans-based health system was searched for all patients with polymerase chain reaction-confirmed sars-cov-2 infection who were either admitted to hospital or ... | 2020 | 33137202 |
| gut microbiota-targeted interventions for reducing the incidence, duration, and severity of respiratory tract infections in healthy non-elderly adults. | respiratory tract infections (rti), such as those caused by influenza viruses and, more recently, the severe acute respiratory syndrome coronavirus-2, pose a significant burden to military health care systems and force readiness. the gut microbiota influences immune function, is malleable, and may provide a target for interventions aiming to reduce rti burden. this narrative review summarizes existing evidence regarding the effectiveness of probiotics, prebiotics, and synbiotics, all of which ar ... | 2020 | 33137200 |
| performance of nucleocapsid and spike-based sars-cov-2 serologic assays. | there is an urgent need for an accurate antibody test for severe acute respiratory syndrome coronavirus 2 (sars-cov-2). we have developed 3 elisa methods, trimer spike iga, trimer spike igg, and nucleocapsid igg, for detecting anti-sars-cov-2 antibodies. we evaluated their performance along with four commercial elisas, edi™ novel coronavirus covid-19 elisa igg and igm, euroimmun anti-sars-cov-2 elisa igg and iga, and one lateral flow assay, dpp® covid-19 igm/igg system (chembio). both sensitivit ... | 2020 | 33137138 |
| rapid sars-cov-2 testing in primary material based on a novel multiplex rt-lamp assay. | rapid and extensive testing of large parts of the population and specific subgroups is crucial for proper management of severe acute respiratory syndrome coronavirus 2 (sars-cov-2) infections and decision-making in times of a pandemic outbreak. however, point-of-care (poc) testing in places such as emergency units, outpatient clinics, airport security points or the entrance of any public building is a major challenge. the need for thermal cycling and nucleic acid isolation hampers the use of sta ... | 2020 | 33137122 |
| reduction in acute coronary syndromes during coronavirus disease 2019 global pandemic: data from the marche region of italy. | during the novel severe acute respiratory syndrome coronavirus 2 (coronavirus disease 2019) pandemic, a worldwide reduction in total acute coronary syndrome (acs) has been reported. in early 2020, italy became the most affected country and national lockdown was declared early on in march. we described trends in acs from all the marche coronary catheterization laboratories (ccl) during the global pandemic. | 2020 | 33136811 |
| impact of covid-19-related stress and lockdown on mental health among people living with hiv in argentina. | the spread of severe acute respiratory syndrome coronavirus 2, causative agent of the coronavirus disease 2019 (covid-19), has necessitated widespread lockdown to mitigate the pandemic. this study examines the influence of resilience on the impact of covid-related stress and enforced lockdown on mental health, drug use, and treatment adherence among people living with hiv (plwh) in argentina. | 2020 | 33136748 |
| the indicative role of markers for liver injury on the severity and prognosis of coronavirus disease 2019 patients. | liver injury in coronavirus disease 2019 (covid-19) patients was poorly understood. | 2020 | 33136731 |
| hydroxychloroquine and covid-19: lack of efficacy and the social construction of plausibility. | severe acute respiratory syndrome coronavirus 2 sars- cov2 has taken the world by surprise. among the first promising repurposing agents proposed for treatment and prophylaxis, 2 antimalarial agents came into limelight: chloroquine and its less toxic derivative, hydroxychloroquine (hcq). intense research and public debates have followed. | 2020 | 33136577 |
| multisystem imaging manifestations of covid-19, part 2: from cardiac complications to pediatric manifestations. | infection with severe acute respiratory syndrome coronavirus 2 results in coronavirus disease 2019 (covid-19), which was declared an official pandemic by the world health organization on march 11, 2020. covid-19 has been reported in most countries, and as of august 15, 2020, there have been over 21 million cases of covid-19 reported worldwide, with over 800 000 covid-19-associated deaths. although covid-19 predominantly affects the respiratory system, it has become apparent that many other organ ... | 2020 | 33136488 |
| a web-based platform on coronavirus disease-19 to maintain predicted diagnostic, drug, and vaccine candidates. | a web-based resource coronavir (https://webs.iiitd.edu.in/raghava/coronavir/) has been developed to maintain the predicted and existing information on coronavirus severe acute respiratory syndrome coronavirus 2 (sars-cov-2). we have integrated multiple modules, including "genomics," "diagnosis," "immunotherapy," and "drug designing" to understand the holistic view of this pandemic medical disaster. the genomics module provides genomic information of different strains of this virus to understand ... | 2020 | 33136473 |
| covid-19 basics and vaccine development with a canadian perspective. | the ongoing coronavirus disease 2019 (covid-19) pandemic is a rapidly evolving situation. new discoveries about covid-19 and its causative virus, severe acute respiratory syndrome coronavirus 2 (sars-cov-2), continue to deepen the understanding of this novel disease. as there is currently no covid-19 specific treatment, isolation is the most effective method to prevent transmission. moreover, development of a safe and effective covid-19 vaccine will be instrumental in reinstating pre-covid-19 co ... | 2020 | 33136431 |
| remdesivir for the treatment of severe covid-19: a community hospital's experience. | following the emergence of the novel severe acute respiratory syndrome coronavirus-2 (sars-cov-2), which causes coronavirus disease 2019 covid-19, researchers sought safe and effective treatment modalities. remdesivir is currently being evaluated for clinical efficacy and safety in patients with covid-19. | 2020 | 33136164 |
| evaluation of droplet digital pcr for quantification of sars-cov-2 virus in discharged covid-19 patients. | the worldwide severe acute respiratory syndrome coronavirus 2 (sars-cov-2) outbreak has led to the rapid spread of coronavirus disease (covid-19). the quantitative real time pcr (qpcr) is widely used as the gold standard for clinical detection of sars-cov-2. however, more and more infected patients are relapsing after discharge, which suggests qpcr may fail to detect the virus in some cases. in this study, we selected 74 clinical samples from 43 recovering inpatients for qpcr and droplet digital ... | 2020 | 33136068 |
| clinical progression and changes of chest ct findings among asymptomatic and pre-symptomatic patients with sars-cov-2 infection in wuhan, china. | to analyze characteristics of asymptomatic/pres-ymptomatic patients with sars-cov-2 infection. | 2020 | 33135909 |
| characterization of antibody responses to sars-cov-2 in convalescent covid-19 patients. | the coronavirus disease 2019 (covid-19) is a pandemic caused by severe acute respiratory syndrome coronavirus 2 (sars-cov-2). however, little is known about the durability of the antibody response during covid-19 convalescent phase. we investigated the prevalence of anti-sars-cov-2 specific antibodies including immunoglobulin g (igg) and immunoglobulin m (igm) antibodies and the dynamic changes in antibody levels in convalescent covid-19 patients. a total of 159 blood samples were collected from ... | 2020 | 33135795 |
| ace2, the kidney and the emergence of covid-19 two decades after ace2 discovery. | angiotensin-converting enzyme ii (ace2) is a homologue of angiotensin-converting enzyme discovered in 2000. from the initial discovery, it was recognized that the kidneys were organs very rich on ace2. subsequent studies demonstrated the precise localization of ace2 within the kidney and the importance of this enzyme in the metabolism of angiotensin ii and the formation of angiotensin 1-7. with the recognition early in 2020 of ace2 being the main receptor of severe acute respiratory syndrome cor ... | 2020 | 33135725 |
| a strategy to treat covid-19 disease with targeted delivery of inhalable liposomal hydroxychloroquine: a pre-clinical pharmacokinetic study. | severe acute respiratory syndrome coronavirus 2 (sars-cov-2) is a newly identified pathogen causing the coronavirus disease 2019 (covid-19) pandemic. hydroxychloroquine (hcq), an antimalarial and anti-inflammatory drug, has been shown to inhibit sars-cov-2 infection in vitro and tested in clinical studies. however, achievement of lung concentrations predicted to have in vivo antiviral efficacy might not be possible with the currently proposed oral dosing regimens. further, high cumulative doses ... | 2020 | 33135382 |
| the noncoding and coding transcriptional landscape of the peripheral immune response in patients with covid-19. | covid-19 is currently a global pandemic, but the response of human immune system to severe acute respiratory syndrome coronavirus 2 (sars-cov-2) infection remains unclear. noncoding rnas serve as immune regulators and thus may play a critical role in disease progression. | 2020 | 33135345 |
| there is a role in detection of sars-cov-2 in conjunctiva and tears: a comprehensive review. | data on the involvement of the ocular surface and its relationship with coronavirus disease 2019 (covid-19) are still minimal and not univocal. the respiratory tract is the structure most affected by covid-19, and the serious form of the disease is characterized by severe pneumonia, acute respiratory distress syndrome and hypercoagulation. however, accumulating evidence shows that other organs could be reached by the virus, thus causing further comorbidities. to date, the exact route / routes of ... | 2020 | 33135085 |
| sars-cov-2 igg/igm rapid test as a diagnostic tool in hospitalized patients and healthcare workers, at a large teaching hospital in northern italy, during the 2020 covid-19 pandemic. | we describe the outcome of a severe acute respiratory syndrome coronavirus 2 (sarscov-2) igg/igm rapid test, and discuss the potential suitability of antibody testing. retrospective single cohort study on patients with suspected coronavirus disease 2019 (covid-19) and asymptomatic healthcare workers, enrolled from march to april 2020. subjects had quantitative pcr (qpcr) test for detection of sars-cov-2 via nasal swab and serological testing using the covid-19 igg/igm rapid test (prima lab sa) i ... | 2020 | 33135083 |
| evaluation of the truvian easy check covid-19 igm/igg lateral flow device for rapid anti-sars-cov-2 antibody detection. | to evaluate the analytical and clinical performance of the truvian easy check coronavirus disease 2019 (covid-19) igm/igg anti-severe acute respiratory syndrome coronavirus 2 (sars-cov-2) antibody test.serologic assays have become increasingly available for surveillance through the food and drug administration emergency use authorization in the ongoing covid-19 global pandemic. however, widespread application of serologic assays has been curbed by reports of faulty or inaccurate tests. therefore ... | 2020 | 33135049 |
| extracorporeal hemoperfusion as a potential therapeutic option for severe covid-19 patients; a narrative review. | the 2019 novel coronavirus (officially known as severe acute respiratory syndrome coronavirus 2, sars-cov2) was first found in wuhan, china. on february 11, 2020, the world health organization (who) has declared the outbreak of the disease caused by sars-cov2, named coronavirus disease 2019 (covid-19), as an emergency of international concern. based on the current epidemiological surveys, some covid-19 patients with severe infection gradually develop impairment of the respiratory system, acute k ... | 2020 | 33134963 |
| legal considerations of covid-19 patients' disposition in emergency department; report of 10 cases. | covid-19 pandemic is a challenge in the current era. the spread of this viral infection began in wuhan city in china, and iran was also one of the countries struggling with it. considering the nature of this virus and the current pandemic, it is essential that the healthcare system authorities issue a clear and firm law on treating people infected with covid-19 to prevent the consequences affecting the professional life of physicians and healthcare staff. the current study aimed at evaluating th ... | 2020 | 33134960 |
| erratum: delayed development of coronary artery dilitation in suspected severe acute respiratory syndrome coronavirus 2 multisystem inflammatory syndrome: more research needed: erratum. | [this corrects the article doi: 10.1097/cce.0000000000000236.]. | 2020 | 33134955 |
| metabolomics profiling of critically ill coronavirus disease 2019 patients: identification of diagnostic and prognostic biomarkers. | coronavirus disease 2019 continues to spread rapidly with high mortality. we performed metabolomics profiling of critically ill coronavirus disease 2019 patients to understand better the underlying pathologic processes and pathways, and to identify potential diagnostic/prognostic biomarkers. | 2020 | 33134953 |
| spectrum of vascular involvement in coronavirus disease 2019 pneumonia-findings on ct perfusion. | there is accumulating evidence of a distinct coagulopathy in severe acute respiratory syndrome coronavirus 2 infection which is associated with poor prognosis in coronavirus disease 2019. coagulation abnormalities in blood samples resemble systemic coagulopathies in other severe infections but demonstrate specific features such as a very high d-dimer. these clinical observations are consistent with histopathologic findings of locally disturbed pulmonary microvascular thrombosis and angiopathy in ... | 2020 | 33134952 |
| resolution of coronavirus disease 2019 infection and pulmonary pathology with nebulized das181: a pilot study. | severe acute respiratory syndrome coronavirus 2 infections commonly lead to respiratory failure and potentially fatal systemic inflammation and organ failure. nebulized das181, a host-directed biologics with sialidase activity, is an investigational drug with antiviral activities on parainfluenza and influenza under phase 3 and phase 2 development. the objective of this study (nct04324489) is to investigate the safety and effects of nebulized das181 on hypoxic coronavirus disease 2019 patients. | 2020 | 33134951 |
| volatile isoflurane in critically ill coronavirus disease 2019 patients-a case series and systematic review. | the ongoing coronavirus pandemic is challenging, especially in severely affected patients who require intubation and sedation. although the potential benefits of sedation with volatile anesthetics in coronavirus disease 2019 patients are currently being discussed, the use of isoflurane in patients with coronavirus disease 2019-induced acute respiratory distress syndrome has not yet been reported. | 2020 | 33134946 |
| timing of intubation and in-hospital mortality in patients with coronavirus disease 2019. | to examine whether increasing time between admission and intubation was associated with mortality in patients with coronavirus disease 2019 who underwent mechanical ventilation. | 2020 | 33134945 |
| corticosteroid responsive encephalopathy: prolonged coma in patients late in the course of dreadful severe acute respiratory syndrome coronavirus 2 infection. | responsible for the coronavirus disease 2019 pandemic that began in december 2019, severe acute respiratory syndrome coronavirus 2 mainly causes respiratory insult. few cases were reported of extrapulmonary involvement, many of which were neurologic. | 2020 | 33134942 |
| clinical pharmacists: an invaluable part of the coronavirus disease 2019 frontline response. | although coronavirus disease 2019 was first identified in december 2019, it rapidly spread and became a global pandemic. the number of patients infected with the novel coronavirus (severe acute respiratory syndrome coronavirus 2) rose rapidly in new york state, placing great stress on healthcare systems. the traditional roles and practices of healthcare providers were dramatically redefined to meet the demand to care for the large number of ill patients. while literature reports on the experienc ... | 2020 | 33134940 |
| extracorporeal membrane oxygenation in severe acute respiratory distress syndrome: possible late indication for coronavirus disease 2019? | there is now substantial evidence to support venovenous extracorporeal membrane oxygenation efficacy and safety for patients with severe acute respiratory distress syndrome. however, recent guidelines recommend against the initiation of extracorporeal membrane oxygenation in patients with mechanical ventilation for coronavirus disease 2019 severe acute respiratory distress syndrome for greater than 7-10 days. | 2020 | 33134938 |
| covid-19 and hematology-what do we know so far? | the severe acute respiratory syndrome-coronavirus-2 (sars-cov-2), the causative agent of the novel coronavirus disease 2019 (covid 19), was reported to the world health organization in late 2019. this disease quickly evolved into a public health concern and was declared a pandemic on march 11, 2020. covid-19's high transmission rate and potential to cause a spectrum of systemic diseases makes it imperative for researchers and clinicians worldwide to collaborate and develop a strategy to manage a ... | 2020 | 33134847 |
| left ventricular thrombus and pulmonary embolism: a case series of thrombosis in covid-19 in thai patients. | thrombosis in covid-19 is increasingly recognized and is generally associated with a high mortality rate. the key clinical question of this report was whether covid-19 could be complicated with cardiac thrombus and pulmonary embolism in asian population. we demonstrated the case series of thrombosis in thai patients with confirmed severe acute respiratory syndrome coronavirus 2 infection. one patient had the first case of a large left ventricular thrombus, and three other patients had pulmonary ... | 2020 | 33134788 |
| pooled testing conserves sars-cov-2 laboratory resources and improves test turn-around time: experience on the kenyan coast. | background. international recommendations for the control of the coronavirus disease 2019 (covid-19) pandemic emphasize the central role of laboratory testing for severe acute respiratory syndrome coronavirus 2 (sars-cov-2), the etiological agent, at scale. the availability of testing reagents, laboratory equipment and qualified staff are important bottlenecks to achieving this. elsewhere, pooled testing (i.e. combining multiple samples in the same reaction) has been suggested to increase testin ... | 2020 | 33134555 |
| covid-19 in kidney transplantation: epidemiology, management considerations, and the impact on kidney transplant practice. | the novel severe acute respiratory syndrome coronavirus 2 was identified in the late 2019 as the cause of coronavirus disease 2019 (covid-19), an acute respiratory viral illness. patients with chronic underlying conditions may have an increased risk of morbidity and mortality from covid-19. kidney transplant recipients may be at a uniquely increased risk of serious complications from covid-19 as compared to the general population because of a chronically immunosuppressed state and a high prevale ... | 2020 | 33134506 |
| treating covid-19 with hydroxychloroquine (teach): a multicenter, double-blind randomized controlled trial in hospitalized patients. | effective therapies to combat coronavirus 2019 (covid-19) are urgently needed. hydroxychloroquine (hcq) has in vitro antiviral activity against severe acute respiratory syndrome coronavirus 2 (sars-cov-2), but the clinical benefit of hcq in treating covid-19 is unclear. randomized controlled trials are needed to determine the safety and efficacy of hcq for the treatment of hospitalized patients with covid-19. | 2020 | 33134417 |
| ssrna virus and host lipid rearrangements: is there a role for lipid droplets in sars-cov-2 infection? | since its appearance, severe acute respiratory syndrome coronavirus 2 (sars-cov-2) has immediately alarmed the world health organization for its very high contagiousness and the complexity of patient clinical profiles. the worldwide scientific community is today gathered in a massive effort in order to develop safe vaccines and effective therapies in the shortest possible time. every day, new pieces of sars-cov-2 infective puzzle are disclosed. based on knowledge gained with other related corona ... | 2020 | 33134318 |
| covid-19 (sars-cov-2) pandemic: fears, facts and preventive measures. | the aim of this review is to give a synopsis on the coronavirus disease 2019 (covid-19) pandemic, with major focus on the preventive measures. ever since the influenza pandemic of 1918, and the second world war of (1939-1945), the world has not been faced with a common problem in recent memory like the covid-19 pandemic. the unprecedented covid-19 pandemic is caused by infection with a viral pathogen, the nascent severe acute respiratory syndrome coronavirus 2 (sars-cov-2), and is characterized ... | 2020 | 33134200 |
| diagnostic testing of covid-19 in solid organ transplantation: current clinical application and future strategies. | while a great deal of literature has been published recently on the viral kinetics of severe acute respiratory syndrome coronavirus 2 (sars-cov-2) infection and diagnostic testing performance for coronavirus disease 2019 (covid-19) in the general population, a relative paucity of information has come to light regarding implications of covid-19 diagnostics for solid organ transplantation. this review examines the current state of knowledge regarding the two principal diagnostic testing strategies ... | 2020 | 33134033 |
| covid-19 infection complicated by a complete occlusion of the left circumflex artery with acute restenosis after drug-eluting stent placement. | severe acute respiratory syndrome coronavirus 2 (sars-cov-2) can cause a hypercoagulable state that can complicate the management of patients presenting with acute myocardial infarction (mi). we present the case of a patient with coronavirus disease 2019 (covid-19) with st elevation mi who was treated with percutaneous coronary intervention and stenting to the left circumflex artery. he was treated appropriately with anticoagulation with appropriate activated clotting time. however, the coronary ... | 2020 | 33133872 |
| an assumed vertical transmission of sars-cov-2 during pregnancy: a case report and review of literature. | the ongoing coronavirus disease 2019 (covid-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (sars-cov-2) has affected persons of all ages, including the newborns. few published case reports and case series have described the possibility of vertical transmission of covid-19. in the present report, we describe a young primigravida at 33 weeks of gestation, who presented with a four-day history of low-grade fever, malaise, and breathing difficulty. she underwent testing of na ... | 2020 | 33133829 |
| covid-19-associated acute limb ischemia in a patient on therapeutic anticoagulation. | coronavirus disease 2019 (covid-19), caused by severe acute respiratory syndrome coronavirus 2 (sars-cov-2), has been found to cause multiple complications across several organ systems in patterns not typically observed in previous iterations of the virus. hemostatic mechanisms have been noted to be significantly altered in particular, resulting in a disseminated intravascular coagulation (dic)-like picture with elements of coagulopathy as well as hypercoagulability. a 65-year-old man with hyper ... | 2020 | 33133825 |
| clinical, radiological, and molecular findings of acute encephalitis in a covid-19 patient: a rare case report. | we report a case of encephalitis in a young male patient with severe coronavirus disease 2019 (covid-19) who initially presented with typical symptoms of fever, dry cough, and shortness of breath but later on developed acute respiratory distress syndrome and required mechanical ventilation. two days post-extubation, the patient developed new-onset generalized tonic-clonic seizures and confusion. mri of the brain was done and it showed an abnormal signal in the bilateral medial cortical frontal r ... | 2020 | 33133820 |
| experience of an orthopaedic surgery department early during the covid-19 outbreak in japan including real-time polymerase chain reaction assay results for sars-cov-2. | introduction the coronavirus disease 2019 (covid-19) epidemic beginning december 2019 in china has now become a worldwide pandemic. with the need to develop an approach to manage orthopaedic surgeries, we aimed to evaluate the most current data on all the surgical cases in our department including the results of the reverse-transcriptase polymerase chain reaction (rt-pcr) assay for infection with severe acute respiratory syndrome coronavirus 2 (sars-cov-2). methods the monthly number of surgical ... | 2020 | 33133795 |
| air leak syndrome in two very preterm infants born to mothers with coronavirus disease 2019: an association or a coincidence? | the novel coronavirus disease 2019 (covid-19) caused by the severe acute respiratory syndrome coronavirus 2 (sars-cov-2) mostly affects adults with limited information on possible vertical transmission from pregnant mothers. we present here two very preterm infants born to mothers with covid-19, whose respiratory course was significant for initial mild respiratory distress syndrome who developed acute onset severe air leak syndrome at approximately 24 to 36 hours of age requiring thoracentesis. ... | 2020 | 33133761 |
| curcumin (a constituent of turmeric): new treatment option against covid-19. | in late december 2019, the outbreak of respiratory illness emerged in wuhan, china, and spreads worldwide. world health organization (who) named this disease severe acute respiratory syndrome coronavirus 2 (sars-cov-2) caused by a new member of beta coronaviruses. several medications are prescribed to patients, and some clinical trials are underway. scientists are trying to find a specific drug against this virus. in this review, we summarize the pathogenesis, clinical features, and current trea ... | 2020 | 33133525 |
| systemic effects of the hormonal treatment of male hypogonadism with preliminary indications for the management of covid-19 patients. | male hypogonadism, defined as an inadequate production of testosterone (t), is associated with a greater morbidity and mortality. epidemiological studies identified t deficiency as a risk factor for cardiovascular disease. also, low serum t levels impact on glucose homeostasis through a worse glucose uptake, utilization, and disposal, and the general negative impact on metabolism. the aim of this review is to provide a comprehensive and updated overview of the effects of t replacement therapy on ... | 2020 | 33133492 |
| pig sera-derived anti-sars-cov-2 antibodies in surface plasmon resonance biosensors. | anti-coronavirusdisease-2019 (covid-19; anti-severe acute respiratory syndrome coronavirus 2 (sars-cov-2)) antibodies against nucleoprotein (np) were purified from pig sera. following the separation of the antibody fraction using a protein-a column, the final yield of the purified antibodies against sars-cov-2 nps was estimated to be 0.26 ± 0.05 % (absolute amount of 143.4 ± 25.2 ng, n=5) from 1 ml of pig sera. the binding activities of the isolated antibodies were confirmed using immunoassay an ... | 2020 | 33133395 |
| endotracheal intubation in patients with covid-19 using an ultrathin flexible gastrointestinal endoscope. | pneumonia caused by severe acute respiratory syndrome coronavirus 2 occasionally becomes severe and requires endotracheal intubation. endotracheal intubation is usually performed using a laryngoscope; however, the operator needs to be in close proximity to the patient's face during the procedure, which increases the risk of droplet exposure. therefore, we simulated fiberoptic endotracheal intubation on a mannequin representing the patient, using an ultrathin flexible gastrointestinal endoscope a ... | 2020 | 33133377 |
| [consequences of the covid-19/sars-cov-2 pandemic for gastroenterology in germany]. | the recommendations of the german society of gastroenterology, digestive and metabolic diseases (dgvs) on coronavirus disease 2019 (covid-19) in gastroenterological patients are accessible on the homepage of the society under information at https://www.dgvs.de/covid-19/. recommendations for protection against severe acute respiratory syndrome coronavirus 2 (sars-cov-2) have been published by the european society of gastrointestinal endoscopy (esge) and the european society of gastroenterology an ... | 2020 | 33133294 |
| host genetic variants potentially associated with sars-cov-2: a multi-population analysis. | clinical outcomes of coronavirus disease 2019 (covid-19), caused by the severe acute respiratory syndrome coronavirus 2 (sars-cov-2) showed enormous inter-individual and inter-population differences, possibly due to host genetics differences. earlier studies identified single nucleotide polymorphisms (snps) associated with sars-cov-1 in eastern asian (eas) populations. in this report, we aimed at exploring the frequency of a set of genetic polymorphisms that could affect sars-cov-2 susceptibilit ... | 2020 | 33133166 |
| analysis of the spectrum of ace2 variation suggests a possible influence of rare and common variants on susceptibility to covid-19 and severity of outcome. | in march 2020, the world health organization declared that an infectious respiratory disease caused by a new severe acute respiratory syndrome coronavirus 2 [sars-cov-2, causing coronavirus disease 2019 (covid-19)] became a pandemic. in our study, we have analyzed a large publicly available dataset, the genome aggregation database (gnomad), as well as a cohort of 37 russian patients with covid-19 to assess the influence of different classes of genetic variants in the angiotensin-converting enzym ... | 2020 | 33133145 |
| virological and serological discordant profiles in covid-19 pneumonia: two atypical clinical cases. | severe acute respiratory syndrome coronavirus 2 (sars-cov-2) infection is primarily diagnosed through viral rna positivity in nasopharyngeal swabs, and it is associated with the early detection of specific immunoglobulins to sars-cov-2 proteins. we describe two moderate coronavirus disease 2019 (covid-19) patients with who score 4/5 at the time of hospitalization, pneumonia, and oxygen saturation <94% and with a strong discrepancy between viral rna and antibodies to sars-cov-2. one patient was p ... | 2020 | 33133098 |
| "fei yan no. 1" as a combined treatment for covid-19: an efficacy and potential mechanistic study. | there has been a large global outbreak of coronavirus disease 2019 (covid-19), caused by severe acute respiratory syndrome coronavirus 2 (sars-cov-2), representing a major public health issue. in china, combination therapy, including traditional chinese medicine (tcm) as a treatment for covid-19 has been used widely. "fei yan no. 1" (qfdyg) is a formula recommended by the hubei government to treat covid-19. a retrospective study of 84 covid-19 patients from hubei provincial hospital of tcm and r ... | 2020 | 33132913 |
| [fatality and risk factors for severe courses of covid-19 pneumonia]. | the severity of severe acute respiratory syndrome coronavirus 2 (sars-cov-2) pneumonia, the course, fatality and mortality are multifactorial and attributable to the immediate parenchymal damage in the region of the lungs (including pulmonary vessels), pre-existing comorbidities, extrapulmonary complications, secondary infections and the quality of the available medical care. in this respect, coronavirus disease 2019 (covid-19) is comparable with other severe community-acquired forms of pneumoni ... | 2020 | 33132796 |
| [the virology of sars-cov-2]. | the new severe acute respiratory syndrome coronavirus 2 (sars-cov-2) has far reaching effects on society, the economy and medical treatment. it is all the more important to understand the characteristics of the virus and to utilize them diagnostically, therapeutically and epidemiologically. this article firstly elucidates the medical importance of coronaviruses in general. then angiotensin-converting enzyme 2 (ace2) as the binding site of sars-cov‑2 and the possible influence on the disease susc ... | 2020 | 33132795 |
| the covid-19: current understanding. | in december 2019, china reported several cases of a new coronavirus disease (covid-19). the covid-19 outbreak, which was initially limited to wuhan, china, has rapidly spread worldwide. infection of the disease occurs through exposure to the virus through inhalation of respiratory droplets or if a person touches a mucosal surface after touching an object with the virus on it. the common symptoms of covid-19 are fever, dry cough, dyspnea (difficult or labored breathing), fatigue, chest pain, and ... | 2020 | 33132617 |
| should we or should we not reuse filtering face piece masks? a review. | disposable filtering face piece respirators (ffrs) are usually not approved for routine practice of decontamination and reuse. however, such practice of decontamination and reuse may be needed only as a crisis capacity strategy to ensure continued availability. the current severe acute respiratory syndrome coronavirus-2 (sars-cov-2) pandemic would help us enlighten about more effective and efficient ways of decontamination and reuse. based on the limited research available, ultraviolet irradiati ... | 2020 | 33132573 |
| the transport medicine society consensus guidelines for the transport of suspected or confirmed covid-19 patients. | severe acute respiratory syndrome coronavirus 2 (sars-cov-2) causes coronavirus disease 2019 (covid-19) and has been declared as a pandemic. covid-19 patients may require transport for diagnostic or therapeutic purposes intra- or interhospital or transport from an outside hospital to a healthcare facility. transport of critically ill or infectious patients is always challenging and involves the integration of various tasks and manpower. the adverse events have been attributed to various factors ... | 2020 | 33132557 |
| reflection of epidemiological impact on burden of injury in tertiary care centre, pre-covid and covid era: "lockdown, a good fortune for saving life and limb". | road traffic injuries continue to be a major public health concern and are a leading cause of death and injury across the world. road transport remains the most favoured mode of transport for both freight and passenger movement in india. as per the world health organization, approximately 1.35 million people die annually on the world's roads, and another 20 to 50 million sustain nonfatal injuries as a result of road traffic crashes. these injuries and deaths have an immeasurable impact on the fa ... | 2020 | 33132548 |
| a deep transfer learning model with classical data augmentation and cgan to detect covid-19 from chest ct radiography digital images. | the coronavirus disease 2019 (covid-19) is the fastest transmittable virus caused by severe acute respiratory syndrome coronavirus 2 (sars-cov-2). the detection of covid-19 using artificial intelligence techniques and especially deep learning will help to detect this virus in early stages which will reflect in increasing the opportunities of fast recovery of patients worldwide. this will lead to release the pressure off the healthcare system around the world. in this research, classical data aug ... | 2020 | 33132536 |
| non-covid-19 patients with life-threatening diseases who visited a fever clinic: a single-center, observational study in tokyo, japan. | objective in fever clinics screening coronavirus disease (covid-19), there could be patients with life-threatening diseases that physicians should not overlook. we exploratorily investigated the final diagnosis among non-covid-19 hospitalized patients who visited the fever clinic. methods this was a retrospective, observational, and single-centered study conducted in the national center for global health and medicine (ncgm), tokyo, japan. we conducted a retrospective chart review of patients who ... | 2020 | 33132334 |
| clinical and microbiological features of asymptomatic sars-cov-2 infection and mild covid-19 in seven crewmembers of a cruise ship. | objective to describe the clinical features and clinical course of individuals diagnosed with asymptomatic sars-cov-2 infection or mild covid-19. patients the study participants consisted of 7 crewmembers of the passenger cruise-liner, diamond princess, who were admitted to our hospital after becoming infected with sars-cov-2 aboard the ship. methods the data on patient background and biochemical test results were obtained from the patients' medical records. all patients had a chest x-ray, and a ... | 2020 | 33132333 |
| the effect of environmental pollution on immune evasion checkpoints of sars-cov-2. | many diverse strategies allow and facilitate severe acute respiratory syndrome coronavirus 2 (sars-cov-2) to evade antiviral innate immune mechanisms. although the type i interferon (ifn) system has a critical role in restricting the dissemination of viral infection, suppression of ifn receptor signals by sars-cov-2 constitutes a checkpoint that plays an important role in the immune escape of the virus. environmental pollution not only facilitates sars-cov-2 infection but also increases infectio ... | 2020 | 33132153 |
| management of paediatric ibd after the peak of covid-19 pandemic in italy: a position paper on behalf of the sigenp ibd working group. | coronavirus disease 2019 (covid-19) caused by severe acute respiratory syndrome coronavirus 2, spreading in italy during the first months of 2020, abruptly changed the way of practicing medicine in this country. as a consequence of the lockdown, the diagnostic and therapeutic management of paediatric chronic conditions, such as inflammatory bowel disease (ibd) has been affected. during the peak of covid-19 pandemic, elective visits, endoscopies and infusions have been postponed, with potential c ... | 2020 | 33132063 |
| mechanisms of sars-cov-2 transmission and pathogenesis. | the emergence of severe acute respiratory syndrome coronavirus 2 (sars-cov-2) marks the third highly pathogenic coronavirus to spill over into the human population. sars-cov-2 is highly transmissible with a broad tissue tropism that is likely perpetuating the pandemic. however, important questions remain regarding its transmissibility and pathogenesis. in this review, we summarize current sars-cov-2 research, with an emphasis on transmission, tissue tropism, viral pathogenesis, and immune antago ... | 2020 | 33132005 |
| pet imaging as a tool for assessing covid-19 brain changes. | a substantial fraction of coronavirus disease 2019 (covid-19) patients experience neurological manifestations. nevertheless, brain changes caused by severe acute respiratory syndrome coronavirus 2 (sars-cov-2) remain largely unknown. here, we provide a brief overview of positron emission tomography (pet) applications that could advance current understanding of cns pathophysiological alterations associated with sars-cov-2 infection. | 2020 | 33131922 |
| impact of the covid-19 pandemic on spanish nephrology services. | the coronavirus disease 2019 (covid-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (sars-cov-2) infection, has required a rapid and drastic transformation of hospitals, and consequently also of spanish nephrology units, to respond to the critical situation. the spanish society of nephrology conducted a survey directed to the heads of nephrology departments in spain that addressed the reorganisation of nephrology departments and activity during the peak of covid-19 pandem ... | 2020 | 33131910 |
| applicability of polyethylene glycol precipitation followed by acid guanidinium thiocyanate-phenol-chloroform extraction for the detection of sars-cov-2 rna from municipal wastewater. | the primary concentration and molecular process are critical to implement wastewater-based epidemiology for severe acute respiratory syndrome coronavirus 2 (sars-cov-2). however, the previously developed methods were optimized for nonenveloped viruses. few studies evaluated if the methods are applicable to the efficient recovery of enveloped viruses from various types of raw sewage. this study aims (1) to compare the whole process recovery of pseudomonas phage φ6, a surrogate for enveloped virus ... | 2020 | 33131851 |
| virus isolation of severe acute respiratory syndrome coronavirus 2 (sars-cov-2) for diagnostic and research purposes. | isolation of the new pandemic virus severe acute respiratory syndrome coronavirus 2 (sars-cov-2) is essential for diagnostic and research purposes including assessment of novel therapeutics. several primary and continuous cell lines are currently used, and new organoid and engineered cell lines are being developed for improved investigation and understanding of the human immune response to this virus. here we review the growth of sars-cov-2 in reference standard cell lines, engineered cell lines ... | 2020 | 33131800 |
| laboratory diagnosis of severe acute respiratory syndrome coronavirus 2. | the first laboratory confirmed case of coronavirus disease 2019 (covid-19) in australia was in victoria on 25 january 2020 in a man returning from wuhan city, hubei province, the people's republic of china. this was followed by three cases in new south wales the following day. the australian government activated the australian health sector emergency response plan for novel coronavirus on 27 february 2020 in anticipation of a pandemic. subsequently, the world health organization declared covid-1 ... | 2020 | 33131799 |
| screening malaria-box compounds to identify potential inhibitors against sars-cov-2 mpro, using molecular docking and dynamics simulation studies. | severe acute respiratory syndrome coronavirus 2 (sars-cov-2) main protease (mpro) is one of the vital drug targets amongst all the coronaviruses, as the protein is indispensable for virus replication. the study aimed to identify promising lead molecules against mpro enzyme through virtual screening of malaria venture (mmv) malaria box (mb) comprising of 400 experimentally proven compounds. the binding affinities were studied using virtual screening based molecular docking, which revealed five mo ... | 2020 | 33131721 |
| diagnostic salivary tests for sars-cov-2. | the diagnosis of severe acute respiratory syndrome coronavirus 2 (sars-cov-2) infection relies on the detection of viral rna by real-time reverse transcription polymerase chain reaction (rrt-pcr) performed with respiratory specimens, especially nasopharyngeal swabs. however, this procedure requires specialized medical personnel, centralized laboratory facilities, and time to provide results (from several hours up to 1 d). in addition, there is a non-negligible risk of viral transmission for the ... | 2020 | 33131360 |
| blood ozonization in patients with mild to moderate covid-19 pneumonia: a single centre experience. | the emerging outbreak of the coronavirus disease 2019 (covid-19) caused by the severe acute respiratory syndrome coronavirus 2 (sars-cov-2) continues to spread worldwide. we prescribed some promising medication to our patients with mild to moderate pneumonia due to sars-cov-2, however such drugs as chloroquine, hydrossichloroquine, azithromycin, antivirals (lopinavir/ritonavir, darunavir/cobicistat) and immunomodulating agents (steroids, tocilizumab) were not confirmed as effective against sars- ... | 2020 | 33131033 |
| an unexplained death after routine cardiac surgery: how long have we dealt with coronavirus disease 2019? | we present a case report of fatal respiratory failure after cardiac surgery in the early stages of the coronavirus disease 2019 outbreak. although not supported by epidemiological data nor clinical course, coronavirus disease 2019 infection was revealed post-mortem by immunohistochemical detection of the severe acute respiratory syndrome coronavirus 2 spike protein in lung tissue. | 2020 | 33130891 |
| host-pathogen interaction in covid-19: pathogenesis, potential therapeutics and vaccination strategies. | the current coronavirus pandemic, covid-19, is the third outbreak of disease caused by the coronavirus family, after severe acute respiratory syndrome and middle east respiratory syndrome. it is an acute infectious disease caused by severe acute respiratory syndrome coronavirus 2 (sars-cov-2). this severe disease is characterised by acute respiratory distress syndrome, septic shock, metabolic acidosis, coagulation dysfunction, and multiple organ dysfunction syndromes. currently, no drugs or vacc ... | 2020 | 33130519 |
| evaluation of a sars-cov-2 lateral flow assay using the plaque reduction neutralization test. | as new tests and technologies advance our understanding and diagnostic capabilities of the severe acute respiratory syndrome coronavirus 2 and the coronavirus disease 2019, they must be appropriately validated to make sure test performance is following manufacturer claims. in this study, we evaluated the vazyme 2019-ncov igg/igm detection kit, which is a lateral flow assay (lfa), by the plaque reduction neutralization test (prnt) using 100 patient plasma/serum samples. as compared to the prnt re ... | 2020 | 33130510 |
| covid-19 and lombardy: testing the impact of the first wave of the pandemic. | italy was the first western country to experience a large coronavirus disease 2019 (covid-19) outbreak and the province of bergamo experienced one of the deadliest covid-19 outbreaks in the world. following the peak of the epidemic in mid-march, the curve has slowly fallen thanks to the strict lockdown imposed by the italian government on 9th march 2020. | 2020 | 33130396 |
| unravelling high-affinity binding compounds towards transmembrane protease serine 2 enzyme in treating sars-cov-2 infection using molecular modelling and docking studies. | the coronavirus disease-19 (covid-19) outbreak that is caused by a highly contagious severe acute respiratory syndrome coronavirus-2 (sars-cov-2) has become a zoonotic pandemic, with approximately 24.5 million positive cases and 8.3 lakhs deaths globally. the lack of effective drugs or vaccine provoked the research for drug candidates that can disrupt the spread and progression of the virus. the identification of drug molecules through experimental studies is time-consuming and expensive, so the ... | 2020 | 33130280 |
| in silico identification of strong binders of the sars-cov-2 receptor-binding domain. | the world is currently witnessing the spread of the deadly severe acute respiratory syndrome coronavirus 2 (sars-cov-2) that causes the coronavirus disease 2019 (covid-19). in less than three months since the first cases were reported, the world health organization declared it a pandemic disease. although several treatment and prevention strategies are currently under investigation, a continuous effort to investigate and develop effective cures is urgently needed. thus, we performed molecular do ... | 2020 | 33130279 |
| residual sars-cov-2 rna in nasal swabs of convalescent covid-19: is prolonged quarantine always justified? | real-time rt-pcr is currently the most sensitive method to detect severe acute respiratory syndrome coronavirus-2 (sars-cov-2). defining whether a patient could be contagious or not in the presence of residual sars-cov-2 rna is of extreme importance in the context of public health. in this prospective multicenter study, virus isolation was prospectively attempted in 387 nasal swabs from clinically recovered patients yet showing low viral load (>30 quantification cycle). the median cq value was 3 ... | 2020 | 33130202 |
| "impact of corticosteroids in covid-19 outcomes: systematic review and meta-analysis". | since its appearance in late 2019, infections caused by severe acute respiratory syndrome coronavirus 2 (sars-cov-2) have created unprecedented challenges for health systems worldwide. multiple therapeutic options have been explored including corticosteroids (cs); preliminary results of cs in coronavirus disease 2019 (covid-19) are encouraging, however, the role of cs is still controversial. | 2020 | 33129791 |
| reply: transcatheter aortic valve implantation during covid-19 pandemic: the device also matters. | | 2020 | 33129686 |
| association of bioelectric impedance analysis body composition and disease severity in covid-19 hospital ward and icu patients: the biac-19 study. | the current severe acute respiratory syndrome coronavirus 2 pandemic is unprecedented in its impact. it is essential to shed light on patient characteristics that predispose to a more severe disease course. obesity, defined as a bmi>30 kg/m2, is suggested to be one of these characteristics. however, bmi does not differentiate between fat mass and lean body mass, or the distribution of fat tissue. the aim of the present study was to assess the body composition of covid-19 patients admitted to the ... | 2020 | 33129597 |
| [from students to healthcare partners: accounts of experiences at the heart of the covid-19 crisis]. | the severe acute respiratory syndrome coronavirus 2 pandemic upset the daily life of all french people, through the fear caused by this disease called covid-19, but also through the changes in lifestyle resulting from sanitary confinement. as health professional students, we also experienced this shock from a professional point of view by supporting the healthcare teams in the context of the launch of the "plan blanc". | 2020 | 33129478 |
| noncoding rnas implication in cardiovascular diseases in the covid-19 era. | coronavirus disease 19 (covid-19) is caused by the infection of the severe acute respiratory syndrome coronavirus 2 (sars-cov-2). although the main clinical manifestations of covid-19 are respiratory, many patients also display acute myocardial injury and chronic damage to the cardiovascular system. understanding both direct and indirect damage caused to the heart and the vascular system by sars-cov-2 infection is necessary to identify optimal clinical care strategies. the homeostasis of the car ... | 2020 | 33129318 |
| dried sars-cov-2 virus maintains infectivity to vero e6 cells for up to 48 h. | severe acute respiratory syndrome-coronavirus-2 (sars-cov-2) is a great concern on both public and veterinary health. multiple studies showed that the sars-cov-2 can persist for few days in wet condition, but it has not been clear whether the virus can maintain the infectivity in dry condition. thus, we measured the infectious titer of dried sars-cov-2 (104 pfu/25 μl droplet) at 0, 0.5, 1, 2, 3, 24, and 48 h. strikingly, the dried sars-cov-2 virus did not lose the infectivity to vero e6 cells fo ... | 2020 | 33129043 |
| risk factors for coronavirus disease 2019 (covid-19) severity and mortality among solid cancer patients and impact of the disease on anticancer treatment: a french nationwide cohort study (gco-002 cacovid-19). | cancer patients are thought to have an increased risk of developing severe coronavirus disease 2019 (covid-19) infection and of dying from the disease. in this work, predictive factors for covid-19 severity and mortality in cancer patients were investigated. | 2020 | 33129039 |
| a multiple therapy hypothesis for treatment of covid-19 patients. | the coronavirus disease 2019 (covid-19) pandemic, which is caused by the severe acute respiratory syndrome coronavirus 2 (sars-cov-2), has killed more than one million people as of october 1, 2020. consequently, a search is on for a treatment that can bring the pandemic to an end. however, treatments (vaccine, antiviral, plasma) that are directed at specific viral proteins (rna polymerase, spike proteins) may not work well against all strains of the virus. therefore, it is hypothesized that a th ... | 2020 | 33129008 |
| human lung stem cell-based alveolospheres provide insights into sars-cov-2-mediated interferon responses and pneumocyte dysfunction. | coronavirus infection causes diffuse alveolar damage leading to acute respiratory distress syndrome. the absence of ex vivo models of human alveolar epithelium is hindering an understanding of coronavirus disease 2019 (covid-19) pathogenesis. here, we report a feeder-free, scalable, chemically defined, and modular alveolosphere culture system for the propagation and differentiation of human alveolar type 2 cells/pneumocytes derived from primary lung tissue. cultured pneumocytes express the sever ... | 2020 | 33128895 |
| unbiased screens show cd8+ t cells of covid-19 patients recognize shared epitopes in sars-cov-2 that largely reside outside the spike protein. | developing effective strategies to prevent or treat coronavirus disease 2019 (covid-19) requires understanding the natural immune response to severe acute respiratory syndrome coronavirus 2 (sars-cov-2). we used an unbiased, genome-wide screening technology to determine the precise peptide sequences in sars-cov-2 that are recognized by the memory cd8+ t cells of covid-19 patients. in total, we identified 3-8 epitopes for each of the 6 most prevalent human leukocyte antigen (hla) types. these epi ... | 2020 | 33128877 |
| a 44-year-old hispanic man with loss of taste and bilateral facial weakness diagnosed with guillain-barré syndrome and bell's palsy associated with sars-cov-2 infection treated with intravenous immunoglobulin. | background this case report is of a patient who presented with loss of taste and facial weakness and was diagnosed with guillain-barre syndrome (gbs) and bell's palsy, associated with severe acute respiratory syndrome coronavirus 2 (sars-cov-2) infection. gbs is a neurological emergency defined as acute inflammatory demyelinating polyneuropathy. the patient responded to intravenous immunoglobulin (ivig) treatment. case report we present the case of a 44-year-old hispanic man who came for evaluat ... | 2020 | 33128540 |
| efficacy and safety of remdesivir in hospitalized covid-19 patients: systematic review and meta-analysis including network meta-analysis. | remdesivir is an antiviral agent that has shown broad-spectrum activity, including against severe acute respiratory syndrome coronavirus 2 (sars-cov-2). clinical trials investigating the role of remdesivir in coronavirus disease 2019 (covid-19) reported conflicting results. this study aimed to systematically review the best available evidence and synthesize the results. several electronic databases were searched for candidate studies up to 12 october 2020. studies eligible for meta-analysis were ... | 2020 | 33128490 |