| plasticity in structural and functional interactions between the phosphoprotein and nucleoprotein of measles virus. | the measles virus (mev) phosphoprotein (p) tethers the polymerase to the nucleocapsid template for transcription and genome replication. binding of p to nucleocapsid is mediated by the x domain of p (xd) and a conserved sequence (box-2) within the c-terminal domain of the nucleoprotein (n(tail)). xd binding induces n(tail) α-helical folding, which in turn has been proposed to stabilize the polymerase-nucleocapsid complex, with cycles of binding and release required for transcription and genome r ... | 2012 | 22318731 |
| measles virus, immune control, and persistence. | measles remains one of the most important causes of child morbidity and mortality worldwide with the greatest burden in the youngest children. most acute measles deaths are owing to secondary infections that result from a poorly understood measles-induced suppression of immune responses. young children are also vulnerable to late development of subacute sclerosing panencephalitis, a progressive, uniformly fatal neurologic disease caused by persistent measles virus (mev) infection. during acute i ... | 2012 | 22316382 |
| oncolytic measles virus prolongs survival in a murine model of cerebral spinal fluid-disseminated medulloblastoma. | medulloblastoma is the most common malignant brain tumor of childhood. although the survival rate of afflicted children has improved considerably over the past several years, a subset of these patients will present with disseminated disease and face a much bleaker prognosis. in addition, patients may present with disseminated disease at recurrence. we previously demonstrated the efficacy of a recombinant oncolytic measles virus (mv) to treat localized medulloblastoma in a mouse xenograft model. ... | 2012 | 22307474 |
| epidemiology and genetic relatedness of measles virus infection in uttar pradesh, india, during 2009-2010. | measles surveillance and epidemiological investigation are beneficial tools for genetic analysis and documentation of the interruption of transmission of endemic measles. in this study, areas of uttar pradesh, india, associated with measles outbreaks were investigated. random blood and urine samples were collected from clinically defined cases. the cases were investigated through extensive house-to house surveys. the cases were diagnosed clinically and serologically, and through genotyping of th ... | 2012 | 22286750 |
| molecular relationship between field and vaccine strain of measles virus and its persistence in pakistan. | countrywide 5.9 million, 0-11 month old children are immunized annually by epi (expended program on immunization) against 8 vaccine preventable diseases including measles and so on. unfortunately the basic immunity centers are not uniform throughout the country. each center provides services to about 27000 people which is inadequate. the purpose of this study was to explore the development of epi pakistan in terms of immunization of measles. | 2012 | 22284834 |
| live-attenuated measles virus vaccine confers cell contact loss and apoptosis of ovarian cancer cells via ros-induced silencing of e-cadherin by methylation. | herein we present a novel molecular mechanism of the antitumor effects of live-attenuated measles virus (mv) vaccine in ovarian cancer. using a 2-de/ms-based comparative proteomics strategy, we identified 17 proteins differentially expressed in live-attenuated mv vaccine-treated skov-3 ovarian cancer cells, including oxidative stress-associated enzymes and cell contact-related proteins, which indicated that live-attenuated mv vaccine could induce aberrant ros activation. it further mediated epig ... | 2012 | 22269942 |
| multigenic control of measles vaccine immunity mediated by polymorphisms in measles receptor, innate pathway, and cytokine genes. | measles infection and vaccine response are complex biological processes that involve both viral and host genetic factors. we have previously investigated the influence of genetic polymorphisms on vaccine immune response, including measles vaccines, and have shown that polymorphisms in hla, cytokine, cytokine receptor, and innate immune response genes are associated with variation in vaccine response but do not account for all of the inter-individual variance seen in vaccinated populations. in th ... | 2012 | 22265947 |
| oncolytic measles virus encoding thyroidal sodium iodide symporter for squamous cell cancer of the head and neck radiovirotherapy. | oncolytic measles virus (mv) encoding the human thyroidal sodium iodide symporter (mv-nis) has proved to be safe after intraperitoneal or intravenous administration in patients with ovarian cancer or multiple myeloma, respectively, but it has not yet been administered through intratumoral injection in humans. squamous cell carcinoma (scc) of the head and neck (scchn) usually is locally invasive and spreads to the cervical lymph nodes, which are suitable for the intratumoral administration of onc ... | 2012 | 22235810 |
| the nucleocapsid protein of measles virus blocks host interferon response. | measles virus (mv) belongs to the genus morbillivirus of the family paramyxoviridae. a number of paramyxoviruses inhibit host interferon (ifn) signaling pathways in host immune systems by various mechanisms. inhibition mechanisms have been described for many paramyxoviruses. although there are inconsistencies among previous reports concerning mv, it appears that p/v/c proteins interfere with the pathways. in this study, we confirmed the effects of mv p gene products of a wild mv strain on ifn pa ... | 2012 | 22226324 |
| targeted lentiviral vectors pseudotyped with the tupaia paramyxovirus glycoproteins. | lentiviral vectors are vectors of choice for many gene therapy applications. recently, efficient targeting of lentiviral vectors pseudotyped with the measles virus (mv) glycoproteins has been reported. however, mv antibodies in patients might limit the clinical use of these vectors. we demonstrate here that lentiviral vectors can also be pseudotyped with the glycoproteins of tupaia paramyxovirus (tpmv), the hemagglutinin (h) and fusion (f) protein. as this animal paramyxovirus has no known close ... | 2013 | 22218301 |
| meeting measles elimination indicators: surveillance performance in a regional area of australia. | the world health organization (who) western pacific region has established specific measles elimination surveillance indicators. there has been concern in australia that these indicators may be too stringent and that measles elimination can occur without all surveillance prerequisites being met, in particular the minimum fever and rash clinician-suspected measles reporting rate with subsequent laboratory exclusion of measles. a regional public health unit in northern new south wales, australia, ... | 2011 | 23908888 |
| molecular epidemiology of measles virus before and after the 2003 mass vaccination campaign for measles/rubella in iran. | molecular epidemiology of measles virus (mv) is important, not only to measure the success of measles vaccination programs but also to monitor the circulation and elimination of the virus worldwide. in this study, we compared mv obtained from patients before the 2003 mass vaccination mr campaign and viruses detected after 2003 until 2008 in iran. | 2011 | 23113053 |
| [effect of storage conditions of clinical materials on virological tests results by rt-pcr]. | obtaining a reliable laboratory test result depends on many factors, among which preanalitical factors play a significant role. the aim of this study was to determine the effect of temperature, storage time of samples and number of freezing and thawing cycles on the results of tests carried out by rt-pcr. the study was conducted in a model of measles virus (rna). the results revealed that: (1) samples of clinical material (serum, cerebrospinal fluid, urine) for testing by rt-pcr can be stored fo ... | 2011 | 22384668 |
| corrigendum to "enhanced antitumor effects of an engineered measles virus edmonston strain expressing the wild-type n, p, l genes on human renal cell carcinoma". | | 2010 | 28178499 |
| interleukin-13 displaying retargeted oncolytic measles virus strains have significant activity against gliomas with improved specificity. | the majority of glioblastoma multiforme (gbm) tumors (80%) overexpress interleukin-13 receptor α2 (il-13rα2), but there is no expression of il-13rα2 in normal brain. vaccine strains of measles virus have significant antitumor activity against gliomas. we tested the hypothesis that measles virus entry could be retargeted via the il-13rα2. mv-gfp-haa-il-13 was generated from the edmonston-nse vaccine strain, by displaying human il-13 at the c-terminus of the h protein, and introducing cd46 and sig ... | 2008 | 28189011 |
| subacute sclerosing panencephalitis : diagnosis and drug treatment options. | subacute sclerosing panencephalitis (sspe) is a chronic progressive, usually fatal disease of uncertain pathogenesis that is associated with the presence of mutant measles virus in the cns. the diagnosis is based on clinical criteria and an elevated titre of measles antibodies in the csf. electroencephalography, imaging studies and measles antibody synthesis rate in the csf provide supportive laboratory data. when csf studies are negative, a brain biopsy is indicated to assess the presence of in ... | 1997 | 23338130 |
| does measles virus cause crohn's disease? | | 1995 | 23282400 |
| atypical demyelinating disease. | a 17 year old girl died after an illness characterized by progressive mental deterioration and severe myoclonic jerks. extensive pathological, virological, and immunological studies failed to support the diagnosis of subacute sclerosing panencephalitis but were compatible with disseminated demyelinating disease. the spinal fluid was positive for measles virus antibodies when examined by the fluorescent antibody technique, by complement fixation, and by haemagglutination inhibition tests, but the ... | 1974 | 4371078 |
| [the measles virus]. | | 1949 | 15407614 |
| systemic virotherapy for multiple myeloma. | the multiple myeloma (mm) treatment scenario has changed considerably over the past few years. several novel targeted therapies are currently under consideration including oncolytic virotherapy. areas covered: this review provides an analysis of the mechanisms of action of virotherapy, and summarizes the preclinical and clinical studies of systemic virotherapy developed for the treatment of mm. different types of viruses have been identified, including: adenovirus, vaccinia virus, herpes simplex ... | 2017 | 28796556 |
| large measles outbreak introduced by asylum seekers and spread among the insufficiently vaccinated resident population, berlin, october 2014 to august 2015. | the largest measles outbreak in berlin since 2001 occurred from october 2014 to august 2015. overall, 1,344 cases were ascertained, 86% (with available information) unvaccinated, including 146 (12%) asylum seekers. median age was 17 years (interquartile range: 4-29 years), 26% were hospitalised and a 1-year-old child died. measles virus genotyping uniformly revealed the variant 'd8-rostov-don' and descendants. the virus was likely introduced by and initially spread among asylum seekers before af ... | 2017 | 28857043 |
| complete genome sequences of mumps and measles virus isolates from three states in the united states. | we report here the full coding sequence of nine paramyxovirus genomes, including two full-length mumps virus genomes (genotypes g and h) and seven measles virus genomes (genotypes b3 and d4, d8, and d9), from respiratory samples of patients from california, virginia, and alabama obtained between 2010 and 2014. | 2017 | 28818890 |
| a measles outbreak in sindh, pakistan caused by a genotype b3 virus. | measles continues to be a major public health issue causing substantial outbreaks worldwide, mostly affecting young children. molecular analysis of measles viruses provides important information on outbreak linkages and transmission pathways that can be helpful towards implementation of appropriate control programs. in pakistan, the control of measles is still tenuous, and progress towards elimination has been irregular and challenging. in the 2013 measles outbreak we received 4,682 sera collect ... | 2017 | 28803415 |
| non-encapsidated 5' copy-back defective-interfering genomes produced by recombinant measles viruses are recognized by rig-i and lgp2 but not mda5. | attenuated measles virus (mv) is one of the most effective and safe vaccine available, making it an attractive candidate vector to prevent other infectious diseases. yet the great capacity of this vaccine still needs to be understood at the molecular level. mv vaccine strains have different type-i interferon-inducing abilities, that partially depend on the presence of 5' copy-back defective interfering genomes (di-rnas). di-rnas are pathogen associated molecular patterns recognized by rig-i-like ... | 2017 | 28768856 |
| measles virus nucleocapsid protein modulates the signal regulatory protein-β1 (sirpβ1) to enhance osteoclast differentiation in paget's disease of bone. | paget's disease of bone (pdb) is a chronic localized bone disorder in an elderly population. environmental factors such as paramyxovirus are implicated in pdb and measles virus nucleocapsid protein (mvnp) has been shown to induce pagetic osteoclasts (ocls). however, the molecular mechanisms underlying mvnp stimulation of ocl differentiation in the pdb are unclear. we therefore determined the mvnp regulated gene expression profiling during ocl differentiation. agilent microarray analysis of gene ... | 2017 | 28840181 |
| efficacy of recombinant measles virus expressing highly pathogenic avian influenza virus (hpaiv) antigen against hpaiv infection in monkeys. | highly pathogenic avian influenza virus (hpaiv) is a serious threat not only to domestic fowls but also to humans. vaccines inducing long-lasting immunity against hpaiv are required. in the present study, we generated recombinant measles virus (mv) expressing the hemagglutinin protein of hpaiv without the multibasic site necessary for its pathogenicity in chickens using the backbone of an mv vaccine strain (rmv-ed-h5ha) or a wild-type mv-derived mutant (rmv-hl-vko-h5ha). we examined protective e ... | 2017 | 28931922 |
| nuphar lutea extracts exhibit anti-viral activity against the measles virus. | different parts of nuphar lutea l. (yellow water lily) have been used to treat several inflammatory and pathogen-related diseases. it has shown that nuphar lutea extracts (nup) are active against various pathogens including bacteria, fungi, and leishmanial parasites. in an effort to detect novel therapeutic agents against negative-stranded rna (- rna) viruses, we have tested the effect of a partially-purified alkaloid mixture of nuphar lutea leaves on the measles virus (mv). the mv vaccine's edm ... | 2020 | 32260270 |
| modeling the measles paradox reveals the importance of cellular immunity in regulating viral clearance. | measles virus (mv) is a highly contagious member of the morbillivirus genus that remains a major cause of childhood mortality worldwide. although infection induces a strong mv-specific immune response that clears viral load and confers lifelong immunity, transient immunosuppression can also occur, leaving the host vulnerable to colonization from secondary pathogens. this apparent contradiction of viral clearance in the face of immunosuppression underlies what is often referred to as the 'measles ... | 2018 | 30592772 |
| control theory helps to resolve the measles paradox. | measles virus (mv) is a highly contagious respiratory morbillivirus that results in many disabilities and deaths. a crucial challenge in studying mv infection is to understand the so-called 'measles paradox'-the progression of the infection to severe immunosuppression before clearance of acute viremia, which is also observed in canine distemper virus (cdv) infection. however, a lack of models that match in vivo data has restricted our understanding of this complex and counter-intuitive phenomeno ... | 2021 | 34007460 |