| accumulation of calycosin and its 7-o-beta-d-glucoside and related gene expression in seedlings of astragalus membranaceus bge. var. mongholicus (bge.) hsiao induced by low temperature stress. | the changes in calycosin and calycosin-7-o-beta-d-glucoside content as well as the expression of genes involved in their biosynthesis were monitored in roots, stems and leaves of astragalus membranaceus bge. var. mongholicus (bge.) hsiao seedlings during 10 days of low temperature treatment. the concentrations of calycosin and its 7-o-beta-d-glucoside in the different tissues were analyzed using high-performance liquid chromatography. higher glycoside contents were observed at 2 degrees c than t ... | 2007 | 17253088 |
| [effects of astragalus membranaceus on th cell subset function in children with recurrent tonsillitis]. | to observe the th cell subset function in children with recurrent tonsillitis (rt) at the remission stage and to study the effects of astragalus membranacus (am) on th cell subset function. | 2006 | 17052394 |
| simultaneous analysis of seven astragalosides in radix astragali and related preparations by liquid chromatography coupled with electrospray ionization time-of-flight mass spectrometry. | a method has been developed for the qualitative and quantitative analysis of pharmacologically active astragalosides isolated from several species of the genus astragalus by high performance liquid chromatography coupled with electrospray ionization time-of-flight mass spectrometry. seven astragalosides in radix astragali and their commercial pharmaceutical preparations were analyzed using the developed method. the extracted ion current chromatograms were obtained from the total ion current chro ... | 2006 | 17017014 |
| solvent effect in 1h nmr spectra of 3'-hydroxy-4'-methoxy isoflavonoids from astragalus membranaceus var. mongholicus. | four 3'-hydroxy-4'-methoxy-isoflavonoids: calycosin-7-o-beta-d-glucopyranoside (1), calycosin (2), pratensein-7-o-beta-d-glucopyranoside (3), and pratensein (4) were isolated from astragalus membranaceus var. mongholicus, among which compound 4 was obtained from this plant for the first time. the solvent effect obscuring (1)h signal patterns of b ring of compounds 1-4 was reported to avoid mis-assignments. previously reported nmr data of compounds 1 and 2 were corrected based on 1d and 2d nmr ex ... | 2006 | 16602082 |
| [standard operating procedure for astragalus membranaceus]. | in order to ensure the superior quality and safety of the raw materials of the chinese herbal medicine, a standard operating procedure for astragalus was established on the base of the gap of the chinese herbal medicine as well as practice investigation and experiments. this standard operating procedure provides the technical requirements for astragalus's growing, field management, controlling of the diseases and pests, harvesting, processing, packing, storing, transporting and quality monitorin ... | 2006 | 16572994 |
| differential effects of isoflavones, from astragalus membranaceus and pueraria thomsonii, on the activation of pparalpha, ppargamma, and adipocyte differentiation in vitro. | compounds that target the peroxisome proliferator-activated receptors pparalpha and ppargamma are used to correct dyslipidemia and to restore glycemic balance, respectively. because the majority of diabetic patients suffer from atherogenic lipid abnormalities, in addition to insulin resistance, ligands are required that can activate both pparalpha and ppargamma. in this study, we used chimeric pparalpha/gamma reporter-gene bioassays to screen herbal extracts with purported antidiabetic propertie ... | 2006 | 16549448 |
| [effects of large dose of astragalus membranaceus on the dendritic cell induction of peripheral mononuclear cell and antigen presenting ability of dendritic cells in children with acute leukemia]. | to explore the effects of large dose of astragalus membranaceus (astragalus) on the dentritic cell (dc) induction in vitro and augumentation by peripheral mononuclear cell (mnc) and on antigen presenting ability of dc in children with acute leukemia. | 2005 | 16313105 |
| application of 3' untranslated region (utr) sequence-based amplified polymorphism analysis in the rapid authentication of radix astragali. | radix astragali (root of astragalus membranaceus) is an important traditional chinese medicine. it has been used as a tonic herb for thousands of years in china. the water extract of the roots has a wide range of immunopotentiating effects and has been proven to be efficacious as an adjunct cancer therapy. authentication of the herbal plant is routinely required for general practice in the field of herbal medicine. to facilitate rapid identification of numerous varieties of radix astragali that ... | 2005 | 16248552 |
| [preparative isolation and purification of calycosin and formononetin from astragalus membranaceus bge. var. mongholicus (bge.) hsiao by high-speed counter-current chromatography]. | preparative high-speed counter-current chromatography (hsccc) was used for the separation of calycosin and formononetin from the ethyl acetate extract of astragalus membranaceus bge. var. mongholicus (bge.) hsiao. calycosin was obtained by hsccc with a binary phase solvent system composed of n-hexane-chloroform-methanol-water (1.5:3:3:2, v/v). then, formononetin was obtained with a system composed of n-hexane-chloroform-methanol-water (4:4:5:4, v/v). the mobile phase was the lower phase and oper ... | 2005 | 16124581 |
| [a review of pharmacological study on astragalus membranaceus (fisch.) bge]. | | 2004 | 15346617 |
| [clinical observation on treatment of diabetic nephropathy with compound fructus arctii mixture]. | to observe the effect of compound fructus arctii mixture (fam, consisted of fructus arctii and ethanol extract of radix astragalus membranaceus) in treating diabetic nephropathy. | 2004 | 15307694 |
| astragaloside iv protects against ischemic brain injury in a murine model of transient focal ischemia. | astragalus membranaceus is a herbal medicine that has been used clinically in stroke patients in china for decades, but its potential neuroprotective effect against ischemic brain injury has not been experimentally tested. in this study, we investigated the effect of astragaloside iv, a purified extract from astragalus membranaceus, in a murine model of focal cerebral ischemia/reperfusion produced by transient (1.5 h) middle cerebral artery occlusion. as determined at 72 h after ischemia, post-i ... | 2004 | 15182947 |
| [modulatory effect of astragalus membranaceus on th1/th2 cytokine in patients with herpes simplex keratitis]. | to explore the influence of astragalus membranaceus (am) on serum cytokines, th1, including interleukin-2 (il-2) and gamma-interferon (gamma-ifn), and th2, including interleukin-4 (il-4) and interleukin-10 (il-10), in patients with herpes simplex keratitis (hsk). | 2004 | 15015443 |
| preparative isolation and purification of isoflavan and pterocarpan glycosides from astragalus membranaceus bge. var. mongholicus (bge.) hsiao by high-speed counter-current chromatography. | (3r)-(-)-7,2'-dihydroxy-3',4'-dimethyl isoflavan-7-o-beta-d-glucopyranoside and (6ar, 11ar) 9,10-di-methoxypterocarpan-3-o-beta-d-glucopyranoside were separated from the ethyl acetate extract of the root of astragalus membranaceus bge. var. mongholicus (bge.) hsiao by high-speed counter-current chromatography (hsccc). a two-phase system composed of ethyl acetate-ethanol-acetic acid-water (4:1:0.25:5, v/v) was selected by analytical hsccc. preparative hsccc yielded, from 100 mg of the partially p ... | 2004 | 14753698 |
| [the effects of endotoxin on the th1/th2 cells and immune modulation of astragalus membranaceus]. | | 2003 | 14744387 |
| astragaloside iv and polysaccharide production by hairy roots of astragalus membranaceus in bioreactors. | hairy roots of astragalus membranaceus were grown in bioreactors up to 30 l for 20 d. cultures from a 30 l airlift bioreactor gave 11.5 g l dry wt with 1.4 mg g(-1) astragaloside iv, similar to cultures from 250 ml and 1 l flasks, but greater than yields from a 10 l bioreactor (dry wt 9.4 g l(-1), astragaloside iv 0.9 mg g(-1)). polysaccharide yields were similar amongst the different bioreactors (range 25-32 mg g(-1)). the active constituent content of the cells approached that of plant extract ... | 2003 | 14677711 |
| antiinflammatory activity of astragaloside iv is mediated by inhibition of nf-kappab activation and adhesion molecule expression. | the regulated expression of adhesion molecules on the surface of endothelial cells is a key process in the pathogenesis of inflammation. the saponin astragaloside iv (as-iv), a 3-o-beta-d-xylopyranosyl-6-o-beta-d-glucopyranosylcycloastragenol purified from the chinese medical herb astragalus membranaceus (fisch) bge. has been shown to have anti-inflammatory effects in vivo. in this study we have investigated the effect of as-iv on cytokine-and lps-stimulated expression of adhesion molecules in a ... | 2003 | 14597987 |
| phylogeny of astragalus in china: molecular evidence from the dna sequences of 5s rrna spacer, its, and 18s rrna. | radix astragali (root of astragalus; huangqi) is a traditional chinese medicine commonly used as an immunostimulant, hepatoprotective, diuretic, antidiabetic, analgesic, expectorant, and sedative drug. although the species of radix astragali have been defined as astragalus membranaceus and a. membranaceus var. mongholicus in pharmacopoeia of china, their taxonomy remains controversial. the phylogenetic relationships among 10 astragalus taxa, which are commonly found in china including a. membran ... | 2003 | 14582964 |
| [induction and identification of polyploid of astragalus membranaceus var. mongholicus]. | in this article, improved agar painting method, with semi-solid of 0.2% colchicine and 0.1% agar, was adopted to treat apical buds of astragalus membranaceus var. mongholicus (bge.) hsiao seedlings. obtained plants were proved to be tetraploids by identification of biological characteristics and chromosome numbers. | 2003 | 14535010 |
| flavonoids and phenol carboxylic acids in the oriental medicinal plant astragalus membranaceus acclimated in poland. | astragalus membranaceus (fisch.) bunge has been was successfully acclimated in central europe. we report the content of isoflavones and some other polyphenolic compounds in roots and aerial parts that have been analyzed by means of tlc and hplc. the total amount of isoflavones in leaves, was 0.55 mg g(-1) dry weight, and of the flavonols--up to 3.54 mg g(-1). in the roots isoflavonoid content was extremely variable, but reached 3.04 mg g(-1), whereas flavonols content was 0.49 mg g(-1). | 2013 | 12939051 |
| preparative isolation and purification of two isoflavones from astragalus membranaceus bge. var. mongholicus (bge.) hsiao by high-speed counter-current chromatography. | two isoflavones, calycosin-7-o-beta-d-glycoside and formononetin-7-o-beta-d-glycoside, were separated from n-butanol extract of the root of astragalus membranaceus bge. var. mongholicus (bge.) hsiao by high-speed counter-current chromatography in two steps using two different solvent systems composed of ethyl acetate-ethanol-n-butanol-water (30:10:6:50, v/v) and ethyl acetate-ethanol-water (5:1:5, v/v). from 200 mg of crude extract, calycosin-7-o-beta-d-glycoside (12 mg) and formononetin-7-o-bet ... | 2003 | 12735475 |
| anti-hyperglycemic effect of fangchinoline isolated from stephania tetrandra radix in streptozotocin-diabetic mice. | kampo medicine, stephania tetrandra radix (stephania) in boi-ogi-to increases the blood insulin level and falls the blood glucose level in streptozotocin (stz)-diabetic ddy mice. these actions of stephania are potentiated by astragalus membranaceus bunge radix (astragali) in boi-ogi-to (liu et al., j. traditional med., 17, 253-260, 2000). in the present study, actions of bis-benzylisoquinoline alkaloids isolated from stephania were investigated in the hyperglycemia of stz-diabetic mice. a main b ... | 2003 | 12612439 |
| astragalus membranaceus. monograph. | | 2003 | 12611564 |
| [clinical study on effect of astragalus in efficacy enhancing and toxicity reducing of chemotherapy in patients of malignant tumor]. | to observe the effect of astragalus membranaceus efficacy enhancing and toxicity reducing on chemotherapy in patients of malignant tumor. | 2002 | 12592686 |
| [characterization and recognition key components in astragalus membranaceus]. | to separate, identify and quantify multi-components in complex traditional chinese medicine (tcm) astragalus membranaceus by unified analysis for systematic study of its relative contents. | 2001 | 12585085 |
| [influence of salvia miltiorrhizae and astragalus membranaceus on hemodynamics and liver fibrosis indexes in liver cirrhotic patients with portal hypertension]. | to observe the influence of salvia miltiorrhiza (sm) and astragalus membranaceus (am) on hemodynamics and liver fibrosis indexes in patients of liver cirrhosis with portal hypertension. | 2001 | 12577420 |
| [observation on collaborative treatment of dilated cardiomyopathy]. | to observe the therapeutic effect of integrated traditional chinese and western medicine (tcm-wm) in treating dilated cardiomyopathy (dcm). | 2001 | 12577349 |
| [effect of ami on proliferative cycle phase of bone marrow cells in mice]. | by using culture of bone marrow cells in vitro and flowcytometry, effect of astragalus membranaceus injection (ami) on proliferative cycle phase of bone marrow cells in normal and anemic mice was studied. ami 40 micrograms/ml (concentration in culture system) can promote normal murine bone marrow cells (bmc) entering proliferative cycle phase (s + m/g2 phase), so do ami 40 micrograms/ml and ami 400 micrograms/ml to anemic murine bmc. the results suggested ami maybe enhance hematopoietic function ... | 2000 | 12575040 |
| [effect of astragalus membranaceus injection on megakaryocyte hematopoiesis in anemic mice]. | to assess the effect of astragalus membranaceus injection (ami) on megakaryocyte hematopoiesis in anemic mice and explore its mechanism. | 2001 | 12528558 |
| preparative isolation and purification of calycosin from astragalus membranaceus bge. var. mongholicus (bge.) hsiao by high-speed counter-current chromatography. | calycosin was purified from an ethyl acetate extract of the root of astragalus membranaceus bge. var. mongholicus (bge.) hsiao by high-speed counter-current chromatography. the separation was performed in two steps with a two-phase solvent system composed of n-hexane-chloroform-methanol-water (1:3:3:2, v/v). from 200 mg of the crude extract, 14.8 mg of calycosin was obtained at over 99% purity as determined by hplc analysis, and its chemical structure was confirmed by ms, 1h and 13c nuclear magn ... | 2002 | 12198969 |
| [determination of 6 isoflavonoids in the hairy root cultures of astragalus membranaceus by hplc]. | an accurate rp-hplc method for the determination of 10-hydroxy-3, 9-dimethoxypeterocarpan, (3r) 8,2'-dihydroxy-7,4'-dimethoxyisoflavan, formonenetin (7-hydroxy-4'-methoxyisoflavone), 8, 3'-dihydroxy-7, 4'-dimethoxy-isoflavone, 2'-hydroxy-3', 4'-dimethoxyisoflavan-7-o-glucopyranoside and alycosin (7,3'-dihydroxy-4'-methoxyisoflavone) in the hairy root cultures of astragalus membranaceus was developed. among them, 10-hydroxy-3, 9-dimethoxypeterocarpan, (3r) 8,2'-dihydroxy-7,4'-dimethoxyisoflavan a ... | 1998 | 11938951 |
| determination of astragaloside iv in radix astragali (astragalus membranaceus var. monghulicus) using high-performance liquid chromatography with evaporative light-scattering detection. | a reverse-phase high-performance liquid chromatographic method is developed for the determination of astragaloside iv, a characteristic constituent in radix astragali. samples are analyzed by means of a reverse-phase column (zorbax eclipse xdb c18) using acetonitrile and water under gradient conditions as the mobile phase for 30 min. an evaporative light-scattering detector is used and set at an evaporating temperature of 43 degrees c with a nebulizing gas (compressed air) pressure of 3.4 bar. t ... | 2001 | 11718305 |
| [a study on processing of the root of astragalus membranaceus bge. by hplc]. | the paper presents a study on the drug-processing of the root of astragalus membranaceus. a hplc method for the determination of astragaloside iv in its processed products has been established. the recovery is 96.1% and the rsd is 2.15%. | 1998 | 11596266 |
| [the effect of herbal medicine including astragalus membranaceus (fisch) bge, codonpsis pilosula and glycyrrhiza uralensis fisch on airway responsiveness]. | to study the effect of astragalus membranceus(fisch) bge, codonpsis pilosula and glycyrrhiza uralensis fisch on airway responsiveness. | 1998 | 11326953 |
| rapd analysis of astragalus medicines marketed in taiwan. | the genetic variability of astragalus medicine materials sold by twenty randomly selected stores in taiwan was investigated using rapd analysis in order to obtain available primers which could clearly differentiate among them. total dna isolated from the rhizomes of the samples were used as templates, and sixty 10 mer arbitrary primers were used in the analysis. the aim of the present study is to construct an identification model of molecular biotechniques applicable to chinese herbal medicines ... | 2000 | 10999446 |
| species identification of radix astragali (huangqi) by dna sequence of its 5s-rrna spacer domain. | about 300 species and varieties of astragalus are identified in china, making the identification of the origin of a particular astragalus species on the consumer market difficult. a molecular genetic approach was developed to identify various species of astragalus. although the 5s-rrna coding sequence is conserved in higher eukaryotes, the spacer domain of the 5s-rrna gene has great diversity among different species. the 5s-rrna spacer domain was amplified by polymerase chain reaction (pcr) from ... | 2000 | 10897476 |
| determination of the components in a chinese prescription, yu-ping-feng san, by rapd analysis. | in this study, the rapd (random amplified polymorphic dna) technique was employed for the first time to determine the components in a chinese herbal prescription. forty decamer oligonucleotide primers were screened in the rapd analysis to identify three chinese medicines, the dried root of astragalus membranaceus (fisch.) bge., the dried root of ledebouriella seseloides wolff, and the dried rhizome of atractylodes macrocephala koidz, in a chinese prescription. only primer opp-10 simultaneously g ... | 1998 | 9776663 |
| the effects of astragalus membranaceus on oxygen consumption in the intestine. | to investigate the effects of astragalus membranaceus (am) on intestinal oxygen consumption both in vivo and in vitro. | 1997 | 27239146 |
| immunomodulating activity of chinese medicinal herbs and oldenlandia diffusa in particular. | the effect of eight different chinese medicinal herbs (cmhs) on lymphocytes was studied in vitro using murine spleen cells. among the studied eight cmhs, astragalus membranaceus and oldenlandia diffusa markedly stimulated murine spleen cells to proliferate. the responder cells for cmhs were b cells, because the response was depleted by the treatment of spleen cells with anti-immunoglobulin (i.g.) antibody and complement and after purification by nylon wool column. this response was not due to co ... | 1997 | 9568540 |
| [a study on combination therapy of western and traditional chinese medicine of acute viral myocarditis]. | to investigate the combination therapy of western and traditional chinese medicine on treatment of acute viral myocarditis, 48 patients were randomly divided into 2 groups. the 1st group consisted of 30 patients, receiving the combination therapy of western and traditional chinese medicine, including astragalus membranaceus, taurine, coenzyme q10 and antiarrhythmics, while the 2nd group consisted of 18 patients, receiving the conventional therapy, including glucose-insulin-potassium (gik), coenz ... | 1996 | 9772585 |
| [nuclear cardiology study on effective ingredients of astragalus membranaceus in treating heart failure]. | the experimental study has testified that among the various effective constituents gained from astragalus membranaceus (am) is the main component. nineteen patients with heart congestive failure were treated with effective ingredient of am, the astragaloside iv (xga) injection. | 1995 | 8732134 |
| [effect of astragalus membranaceus on t-lymphocyte subsets in patients with viral myocarditis]. | the efficacy of astragalus membranaceus (am) oral liquor combined with routine therapy and routine therapy alone on t-lymphocyte subsets of peripheral blood in viral myocarditis patients have been studied. the results showed that the t-lymphocyte subsets profile and okt4/okt8 ratio of peripheral blood were significantly lower in viral myocarditis patients than that in healthy control (p < 0.05, 0.01). routine therapy combined with am could significantly enhance okt3, okt4 and okt4/okt8 ratio in ... | 1995 | 7549379 |
| [effects of astragalus membranaceus on left ventricular function and oxygen free radical in acute myocardial infarction patients and mechanism of its cardiotonic action]. | dynamic observations for 4 weeks were made on left ventricular function and oxygen free radical (ofr) in 43 patients first suffering from acute myocardial infarction and hospitalized in coronary care unit with an attack less than 36 hours. the results showed that the astragalus membranaceus (am) could strengthen the left ventricular function and had an effect of anti-ofr. after administration of am, the ratio of pre-ejection period/left ventricular ejection time (pep/lvet) was decreased, the sup ... | 1995 | 7647526 |
| [clinical observation on the treatment of ischemic heart disease with astragalus membranaceus]. | 92 patients suffering from ischemic heart disease was successfully treated with astragalus membranaceus (am). the effect of the treatment was compared with that of nifedipine and tab. salviae miltiorrhizae. the clinical practice showed that the group treated with am yielded better results. after having administered the drug, the patients were markedly relieved from angina pectoris (heart stroke). meanwhile the improvement of clinical objective index such as electrocardiogram (ekg) and impedance ... | 1995 | 7787395 |
| [effects of shi-ka-ron and chinese herbs in mice treated with anti-tumor agent mitomycin c]. | the shi-ka-ron, and its constituent chinese herbs lithospermum erythrorhizon, astragalus membranaceus and ligusticum wallichii were administered with antitumor agent, mitomycin c (mmc) to icr mice, and their effects on murine macrophages and lymphocytes were studied. peritoneal macrophages were significantly inhibited both in their number and chemotactic activity by mmc treatment. splenic weight and blastogenic responsiveness to concanavalin a of spleen lymphocytes also decreased significantly i ... | 1995 | 7787389 |
| [experimental studies on the effects of danggui buxue decoction on il-2 production of blood-deficient mice]. | danggui buxue decoction has shown the effect of significantly promoting the splenic capacity of blood-deficient mice in interleukin-2(il-2)production (p < 0.001). individual analysis of herbal formula has shown that il-2 production can be promoted in splenic lymphocytes of blood-deficient mice given angelica sinensis or astragalus membranaceus (p < 0.001). | 1994 | 7718137 |
| [memory-improving effect of aqueous extract of astragalus membranaceus (fisch.) bge]. | the study shows that the aqueous extract of astragulus membranaceus (amwe) can improve the anisodine-induced impairment on memory acquisition as well as the alcohol-elicited deficit of memory retrieval (number of errors were reduced and latent period was prolonged) in step down, and can also prolong the gasping duration of mice after decapitation at doses of 50g/kg (ig) for 7 days. | 1994 | 7893391 |
| cycloartane triterpene glycosides from the hairy root cultures of astragalus membranaceus. | agroastragaloside ii, a new astragaloside was isolated from the hairy root culture of astragalus membranaceus. its structure was established as 3-o-beta-(2'-o-acetyl)-d-xylopyranosyl-6-o-beta-d-glucopyranosyl-(24s)- 3 beta,6 alpha,16 beta,24,25-pentahydroxy-9,19-cyclolanostane on the basis of spectroscopic data. three known astragalosides, astragaloside ii, isoastragaloside i and 3-o-beta-d-xylopyranosyl-cycloastragenol were also isolated. | 1994 | 7765758 |
| [intervention of lidocaine and astragalus membranaceus on ventricular late potentials]. | 16 and 22 patients with positive ventricular late potentials (lp) recorded on signal-averaged electrocardiograms (saecg) were treated with lidocaine 100 mg iv. or astragalus membranaceus 24 g iv. drip for 2 weeks respectively. as a result, the saecgs of 2 (12.5%) and 3 (13.6%) of them normalized respectively. compared with baseline, there were no significant changes in average hfqrsd, las and rms 40 after treatment of lidocaine. hfqrsd and las were shortened significantly 115.9 +/- 29.9 vs 125.1 ... | 1994 | 7719092 |
| [on the pharmacognosy of astragalus membranaceus tish (bge)]. | | 2014 | 5611766 |
| [advances in immuno-pharmacological studies on astragalus membranaceus]. | | 1986 | 2425990 |
| [quantitative determination of astragaloside a in astragalus membranaceus]. | | 1986 | 2952353 |
| [synergism of astragalus membranaceus with interferon in the treatment of cervical erosion and their antiviral activities]. | | 1987 | 3319216 |
| [changes in proteinuria, renal function and immunity after treatment with injections of a solution of astragalus membranaceus]. | | 1987 | 3690764 |
| [isolation and identification of chemical constituents of astragalus root]. | ten constituents have been isolated from the alcoholic extract of astragalus membranaceus var. monghlicum root. all of them were identified. among them astraisoflavanin (3s-(-)-mucronulatol-7-o-d-glucopyranoside) is a new compound. dimethyl 4,4'-dimethoxy-5,6,5',6'-dimethylenedioxybiphyenyl 1-2, 2'-dicarboxylate is a known synthetic compound, but it was first isolated from natural resource astragalus root and identified by the authors. | 1990 | 2092578 |
| [the combined modulating effects of cerium nitrate with certain chinese traditional drugs on altered cell-mediated immunities in scald mice]. | altered cell-mediated immunities (cmi) is one of the important causes of increased susceptibility to infection and, high mortality of burned patients. this paper presents the experimental work on mice with scald injury to restore their altered cmi by local application of cerium nitrate (ce) or systemic administration of astragalus membranaceus (am) or lonicera japonica thunb (ljt), as well as combination use of these drugs. the proliferative response to con a and the ability of il-2 production o ... | 1990 | 2086133 |
| hepatoprotective effects of astraglus root. | oral administration of an ethanol extract of the root of astragalus membranaceus alleviated liver injury induced by stilbenemidine. pre-administration in mice reduced elevated sgpt levels and subacute toxicity of stilbenemidine, decreased pentobarbital-induced loss of righting reflex and protected hepatic cells from pathological changes. | 1990 | 2255205 |
| enhancement of the immune response in mice by astragalus membranaceus extracts. | astragalus membranaceus extracts injected into normal mice or mice immunodepressed by cyclophosphamide or radiation treatment or by aging are able to enhance the antibody response to a t-dependent antigen. optimal conditions for maximum effect have been established in normal c3h/hej and (c57b1/10 x dba/2)f1 mice. enhancement of the antibody response was associated with increase of th cell activity in normal and immunodepressed mice. the biological activity of endotoxin-free extracts is dependent ... | 2003 | 2149722 |
| [effect of astragalus membranaceus on erythrocyte sodium content and sodium transport in the coronary heart disease]. | the purpose of this study was to investigate the effect of astragalus membranaceus (am) on erythrocyte sodium content and sodium transport in the coronary heart disease(chd). 67 cases of chd was randomly divided into treatment group (tg) and control group (cg), tg (45 cases) were treated with am intravenous 24 g/d infused into 5% glucose 250 ml, cg (22 cases) with 5% glucose 250 ml. after a curable stage of 14 days, results showed that the erythrocyte sodium content was markedly decreased and th ... | 1991 | 1667511 |
| [effects of mixture of astragalus membranaceus, fructus ligustri lucidi and eclipta prostrata on immune function in mice]. | a chinese medicine mixture containing astragalus membranaceus, fructus ligustri lucidi and eclipta prostrata(afe), was fed to mice 9g/kg, 20g/kg, respectively for seven days. observe the effects of afe on the immune function in mice. the experiment showed that the two dosages of afe could obviously raise the conversion percentage of lymphocytes (p < 0.01) and serum igg level (41%-47%) of the mice. the weights of the thymus and spleensed increased in the two groups compared with those in the norm ... | 1992 | 1304546 |
| phytochemicals potentiate interleukin-2 generated lymphokine-activated killer cell cytotoxicity against murine renal cell carcinoma. | the success of adoptive immunotherapy using recombinant interleukin-2 (ril-2) and lymphokine-activated killer (lak) cells in several cancers has been hampered by severe toxicity associated with high doses of ril-2. methods that reduce the dosage of ril-2 without loss of clinical efficacy are needed. in this study we determined the in vitro effect of a phytochemical immune modulator, astragalus membranaceus (am), and two fractions isolated by high-performance liquid chromatography on the cytotoxi ... | 1992 | 1445669 |
| [effects of exercise in the growing stage in mice and of astragalus membranaceus on immune functions]. | a study was carried out to examine the effects of forced running exercise in the growing stage in male icr mice and of astragalus membranaceus (as) on their immune functions. the mice were divided at 4 weeks of age into 4 groups. the first group of mice received forced running exercise (e-group), the second group was given as (as-group), the third group received the forced running exercise and was given as (e+as-group) and the fourth group was a control receiving no treatment. the exercise recei ... | 1993 | 8388067 |
| [effect of astragalus membranaceus on cardiovascular system]. | | 1993 | 8251732 |
| [positive modulating action of shengmaisan with astragalus membranaceus on anti-tumor activity of lak cells]. | enhancing the anti-tumor activity of lak cells is one of problems which are expected to be solved in tumor clinic at present. the effects of shengmaisan with astragalus membranaceus (smam) on anti-tumor activity of lak cells with the 3h release assay were studied. the lak cells taken from 43 persons showed obvious killing activity to acute leukemia cells from 8 patients in different types. the results showed that the activity of lak cells could be enhanced markedly by the synergic action of smam ... | 1993 | 8111199 |
| [clinical and experimental studies of effects of huayu decoction on scavenging free radicals]. | infantile pneumonia has been treated successfully with huayu decoction (hyd) in our department for more than ten years. according to the principles of huoxue huayu of tcm, the composition of huayu decoction is as follows: angelica sinensis, paeonia lactiflora, ligusticum wallichii, spathollobus suberectus, hirudo nipponica, tabanus bivittatus, paeonia suffroticosa, astragalus membranaceus . 49 cases of infantile pneumonia were treated with hyd. the activity of erythrocyte superoxide dismutases ( ... | 1993 | 8312693 |
| [effect of jian yan ling on serum lipids, apoprotein and lipoprotein-a]. | effect of jian yan ling (jyl, mainly consisted of succinum, pteria margaritifers and astragalus membranaceus etc.) on serum lipids was studied by double-blind method in 128 hyperlipemia patients. patients were divided randomly into two groups, the test groups (64 cases) treated with jyl, while the other 64 cases treated with placebo as control for 3 months. serum total cholesterol (tc), triglyceride (tg), tc-high density lipolipid-cholesterol (tc-hdl-c), apoproteins were observed before and afte ... | 1994 | 7950180 |
| [the in vitro potentiation of lak cell cytotoxicity in cancer and aids patients induced by f3--a fractionated extract of astragalus membranaceus]. | the in vitro induction of lak cell activity was studied in cancer and aids patients. f3, an immuno-regulatory component of astragalus membranaceus was shown capable of potentiating the lak cell inducing activity of ril-2. the killing activity against hs294t melanoma cell line of lak cells induced by 50 u/ml ril-2 in the presence of f3 (55 micrograms/ml) reached 64% which was comparable to that (60%) induced by 500 u/ml of ril-2 alone. with f3 plus ril-2, the effector to target cell ratio could b ... | 1994 | 7956691 |
| [action of astragalus membranaceus on left ventricular function of angina pectoris]. | the action on left ventricular function of astragalus membranaceus (am), a qi-tonic, in 20 patients with angina pectoris was studied by means of doppler echocardiogram (dec). it showed that cardiac output increased from 5.09 +/- 0.21 to 5.95 +/- 0.18 l/min 2 weeks after am was administered (p < 0.01), and no improvement of left ventricular diastolic function appeared. adenosine triphosphatase activity was not inhibited by using am, which was different from that of digitalis. | 1994 | 7950192 |