| [study on action mechanism of danhong injection based on computational system biology approach]. | danhong injection is a compound preparation of traditional chinese medicine salvia miltiorrhiza and carthamus tinctorius, and has been widely applied in treating coronary heart diseases and ischemic encephalopathy in clinic. despite the complexity of its chemical compounds and the diversity of targets, especially in system biology, there have not a report for its action mechanism as a whole regulatory biological network. in this study, protein data of s. miltiorrhiza and c. tinctorius were searc ... | 2015 | 26084184 |
| evaluation of the antioxidant potential of salvia miltiorrhiza ethanol extract in a rat model of ischemia-reperfusion injury. | the present study was undertaken to evaluate the protection potential of ethanol extract of salvia miltiorrhiza (smee) against oxidative injury in the ischemia-reperfusion (i/r) model of rats in vivo. rats were divided into six groups of 10 rats each. group i/r model and sham were fed with a standard rat chow, groups smee i and smee ii were fed with a standard rat chow and 400 or 800 mg/kg b.w. ethanol extract for 12 days before the beginning of i/r studies. positive control group was fed with a ... | 2011 | 22138858 |
| protective effects of 3,4-dihydroxyphenyl lactic acid on lipopolysaccharide-induced cerebral microcirculatory disturbance in mice. | this study intended to examine the effect of 3,4-dihydroxyphenyl lactic acid (dla), a major ingredient of salvia miltiorrhiza, on lipopolysaccahride (lps) -induced mouse cerebral cortical microcirculatory disturbance. velocity of red blood cells in, and albumin leakage from venules, and the numbers of leukocytes rolling on, and adherent to the venular wall were determined by an up-right microscope after lps (5 mg/kg/h) infusion with or without administration of dla (5 mg/kg/h). expression of adh ... | 2012 | 22240362 |
| immunomodulatory effects of danshen (salvia miltiorrhiza) in balb/c mice. | danshen, the root and rhizome of salvia miltiorrhiza bge, a traditional chinese medicine, especially for cardiovascular and cerebrovascular diseases, has unique immunomodulatory effects. danshen is capable of anti-inflammation and antiallergy, which are immunosuppressive activities, whereas it is also able to promote immunity against cancer, viruses, and bacteria. most previous reports were performed with use of a purified compound or compounds of danshen. since there are more than twenty active ... | 2012 | 24049654 |
| [cloning and distribution pattern of hmgr gene conserved fragment in alisma orientale]. | to clone and study the distribution pattern of 3-hydroxy-3-methylglutaryl coenzyme a reductase (hmgr) gene conserved fragment in alisma orientale. | 2011 | 22259996 |
| [tissue distribution in mice of danshensu from sodium danshensu and salvia miltiorrhiza injection]. | to determine the concentration in mice of danshensu from sodium danshensu and salvia miltiorrhiza injection and undertake comparative study of them as well as to assess the effect of other components of s. miltiorrhiza injection on the tissue distribution of danshensu. | 2011 | 22779190 |
| salvianic acid a protects l-02 cells against γ-irradiation-induced apoptosis via the scavenging of reactive oxygen species. | salvianic acid a (saa) is the main hydrophilic active ingredient of salvia miltiorrhiza bunge, which has long been used to treat liver and heart disease in china. in the present study, we investigated the radioprotective effects of saa against γ-radiation-induced apoptosis in cultured human embryo liver l-02 cells. the results demonstrated that saa markedly inhibited γ-radiation induced apoptosis, decreased dna damage, and increased the intracellular antioxidative ability of the l-02 cells. saa ... | 2012 | 23274418 |
| [optimizing expression of recombinant jasmonate zim-domain protein from salvia miltiorrhiza]. | accumulation of tanshinton in salvia miltiorrhiza are enhanced by exogenous application of jasmonates. the core ja signaling module coi1/jaz/myc2 play a central role on control of downstream gene expression in the ja pathway. to obtained the antibody of smjaz, smjaz recombinant protein was expressed in escherichia coli and optimal expression was performed. | 2012 | 23627165 |
| determination and biosynthesis of multiple salvianolic acids in hairy roots of salvia miltiorrhiza. | danshen (salvia miltiorrhiza bunge) hairy roots were obtained by infecting danshen leaves with agrobacterium rhizogenes 9402. besides rosmarinic acid (ra) and salvianolic acid b (sab), the hairy root could also produce salvianolic acid k (sak), salvianolic acid l, ethyl salvianolic acid b (esab), methyl salvianolic acid b (msab), and a compound with a molecular weight of 538 (compound 538) identified by using lc-ms. effects of methyl jasmonate (meja) and yeast elicitor (ye) on the accumulation o ... | 2011 | 22260028 |
| [construction of plant expression vectors with pmi gene as selection marker and their utilization in transformation of salvia miltiorrhiza f. alba]. | to construct plant expression pcambia1301-pmi by substituting pmi for hygromycin resistance gene in pcambia1301 and obtain transgenic salvia miltiorrhiza f. alba using pmi-mannose selection system. | 2014 | 25011255 |
| from bioprofiling and characterization to bioquantification of natural antibiotics by direct bioautography linked to high-resolution mass spectrometry: exemplarily shown for salvia miltiorrhiza root. | phytochemicals are promising agents in the development of new antibiotics. a streamlined strategy for rapid screening and reliable characterization of antibiotics in botanicals was demonstrated in contrast to the commonly applied chromatographic column fractionation followed by microtiter plate assay. modern direct bioautography hyphenated to structure elucidation techniques is a straightforward bioanalytical tool, especially if microbiological assays were taken into account. at one go, lipophil ... | 2016 | 27766834 |
| effects of abscisic acid, gibberellin, ethylene and their interactions on production of phenolic acids in salvia miltiorrhiza bunge hairy roots. | salvia miltiorrhiza is one of the most important traditional chinese medicinal plants because of its excellent performance in treating coronary heart disease. phenolic acids mainly including caffeic acid, rosmarinic acid and salvianolic acid b are a group of active ingredients in s. miltiorrhiza. abscisic acid (aba), gibberellin (ga) and ethylene are three important phytohormones. in this study, effects of the three phytohormones and their interactions on phenolic production in s. miltiorrhiza h ... | 2013 | 24023778 |
| [microecological mechanisms of red-leaf disease occurrence in salvia miltiorrhiza bge]. | a comparative study was made on the nutrient content in rhizosphere soil and the microflora in rhizosphere soil and on rhizoplane of healthy and red-leaf diseased salvia miltiorrhiza plants, aimed to approach the microecological mechanisms of red-leaf disease occurrence in s. miltiorrhiza. the n, p, k, and mn contents in the diseased plant leaves were significantly lower than those in the healthy plant leaves (p < 0.05). no significant difference was observed in the available p content in the rh ... | 2013 | 24175532 |
| phoma glomerata d14: an endophytic fungus from salvia miltiorrhiza that produces salvianolic acid c. | in recent years, more and more researches focus on endophytic fungi derived from important medicinal plants, which can produce the same bioactive metabolites as their host plants. salvia miltiorrhiza bunge is a traditional medicinal plant with versatile pharmacological effects. but the wild plant resource has been in short supply due to the overcollection for bioactive metabolites. our study was therefore conducted to isolate endophytic fungi from s. miltiorrhiza and get candidate strains that p ... | 2016 | 26979309 |
| traditional chinese medicine and related active compounds: a review of their role on hepatitis b virus infection. | since the significant public health hazard of hepatitis b virus (hbv) infection and obvious drug resistance and dose-dependent side effects for common antiviral agents (e.g., interferon α, lamivudine, and adefovir), continuous development of agents to treat hbv infection is urgently needed. traditional chinese medicine (tcm) is an established segment of the health care system in china. currently, it is widely used for chronic hepatitis b (chb) in china and many parts of the world. over a long pe ... | 2013 | 24423652 |
| characterization of two genes for the biosynthesis of abietane-type diterpenes in rosemary (rosmarinus officinalis) glandular trichomes. | rosemary (rosmarinus officinalis) produces the phenolic diterpenes carnosic acid and carnosol, which, in addition to their general antioxidant activities, have recently been suggested as potential ingredients for the prevention and treatment of neurodegenerative diseases. little is known about the biosynthesis of these diterpenes. here we show that the biosynthesis of phenolic diterpenes in rosemary predominantly takes place in the glandular trichomes of young leaves, and used this feature to id ... | 2014 | 24569175 |
| magnesium lithospermate b and rosmarinic acid, two compounds present in salvia miltiorrhiza, have potent antiviral activity against enterovirus 71 infections. | the aim of this study was to identify the active ingredients responsible for the anti-ev71 activity produced by salvia miltiorrhiza extracts. a pgs-ev71 ires-based bicistronic reporter assay platform was used for rapid analysis of compounds that could specifically inhibit ev71 viral ires-mediated translation. the analysis identified 2 caffeic acid derivatives, magnesium lithospermate b (mlb) and rosmarinic acid (ra), which suppressed ev71 ires-mediated translation at concentrations of 30μg/ml. w ... | 2015 | 25773498 |
| smlea2, a gene for late embryogenesis abundant protein isolated from salvia miltiorrhiza, confers tolerance to drought and salt stress in escherichia coli and s. miltiorrhiza. | abiotic stresses, such as drought and high salinity, are major factors that limit plant growth and productivity. late embryogenesis abundant (lea) proteins are members of a diverse, multigene family closely associated with tolerance to abiotic stresses in numerous organisms. we examined the function of smlea2, previously isolated from salvia miltiorrhiza, in defense responses to drought and high salinity. phylogenetic analysis indicated that smlea2 belongs to the lea_2 subfamily. its overexpress ... | 2017 | 27193100 |
| identification of geranylgeranyl diphosphate synthase genes from tripterygium wilfordii. | we found triptolide synthesis is correlated with the expressions of twggpps1 and twggpps4 . this lays the foundation for future studies of biosynthetic pathways for triptolide and other diterpenoids in t. wilfordii. tripterygium wilfordii is a traditional chinese medical plant commonly used to treat rheumatoid arthritis. one of its main bioactive compounds is triptolide, which is identified as an abietane-type diterpenoid natural product. geranylgeranyl diphosphate synthase (ggpps) catalyses the ... | 2015 | 26449416 |
| [cloning and prokaryotic expression analysis of squalene synthase 2 (sqs2) from salvia miltiorrhiza f. alba]. | according to the designed specific primers of gene fragment based on the salvia miltiorrhiza transcriptome data, a full-length cdna sequence of sqs2 from s. miltiorrhiza f. alba was cloned by the method of reverse transcription polymerase chain reaction (rt-pcr). the smsqs2 cdna sequence was obtained, this sequence is named smsqs2 and its genbank registration number is km244731. the full length of smsqs2 cdna was 1245 bp, encoding 414 amino acids including 5'utr 115 bp and 3'utr 237 bp. sequence ... | 2015 | 26281542 |
| [cloning and prokaryotic expression analysis of hds from salvia miltiorrhiza bge.f.alba]. | according to the designed specific primers of gene fragment based on the salvia miltiorrhiza transcriptome data, with the method of reverse transcription polymerase chain reaction (rt-pcr), this study cloned full-length cdna sequence of 1-hydroxy-2-methyl-2-(e)-butenyl-4-diphosphate synthase gene from salvia miltiorrhiza bge.f.alba, this sequence is named as smhds and its genbank registration number is kj746807. smhds, 2 529 bp long, contains an orf of 2 229 bp, encodes 742 amino acids, includin ... | 2014 | 25757291 |
| [optimization of expression and purification of recombinant salvia miltiorrhiza wrky1 protein in escherichia coli]. | wrky transcription factor is one of the zinc finger proteins which contains a highly conserved wrky domain and is a family of the plant-specific transcription factor. the plasmid pet28a-smwrky1 harboring salvia miltiorrhiza wrky1 (smwrky1) gene was successfully transformed and expressed in escherichia coli bl21 (de3). the conditions on protein expression of smwrky1 in e. coli, including induction duration, temperature, iptg concentration and the e. coli concentration were optimized. the results ... | 2014 | 25011256 |
| overexpression of smlea enhances salt and drought tolerance in escherichia coli and salvia miltiorrhiza. | salinity and drought are important abiotic stresses limiting plant growth and development. late embryogenesis abundant (lea) proteins are a group of proteins associated with tolerance to water-related stress. we previously cloned an lea gene, smlea, from salvia miltiorrhiza bunge. phylogenetic analysis indicated that smlea belongs to group lea14, which is involved in the dehydration response. to determine its function in detail, we have now overexpressed smlea in escherichia coli and s. miltiorr ... | 2014 | 24595620 |
| metabolic engineering of escherichia coli for production of salvianic acid a via an artificial biosynthetic pathway. | salvianic acid a, a valuable derivative from l-tyrosine biosynthetic pathway of the herbal plant salvia miltiorrhiza, is well known for its antioxidant activities and efficacious therapeutic potential on cardiovascular diseases. salvianic acid a was traditionally isolated from plant root or synthesized by chemical methods, both of which had low efficiency. herein, we developed an unprecedented artificial biosynthetic pathway of salvianic acid a in e. coli, enabling its production from glucose di ... | 2013 | 23774671 |
| cloning, molecular characterization and functional analysis of 1-hydroxy-2-methyl-2-(e)-butenyl-4-diphosphate reductase (hdr) gene for diterpenoid tanshinone biosynthesis in salvia miltiorrhiza bge. f. alba. | the enzyme 1-hydroxy-2-methyl-2-(e)-butenyl-4-diphosphate reductase (hdr) is a terminal-acting enzyme in the plastid mep pathway, which produce isoprenoid precursors. the full-length cdna of hdr, designated smhdr1 (genbank accession no. jx516088), was isolated for the first time from salvia miltiorrhiza bge. f. alba. smhdr1 contains a 1389-bp open reading frame encoding 463 amino acids. the deduced smhdr1 protein, which shows high identity to hdrs of other plant species, is predicted to possess ... | 2013 | 23770591 |
| [research wilt disease of salvia miltiorrhiza and its pathogen]. | salvia miltiorrhiza is a highly valued traditional chinese medicine for the treatment of atherosclerosis-related disorders in china, such as cardiovascular and cerebrovascular diseases in china. the wilt disease is serious in the culture of s. miltiorrhiza. wilt disease cause biomass of plant shoots and roots is lessened, active components are decreased. to solve these problems, we research the pathogen causing wilt disease of s. miltiorrhiza. the suspected pathogen is identified by morphology a ... | 2013 | 24791484 |
| inflammatory and apoptotic regulatory activity of tanshinone iia in helicobacter pylori-infected cells. | helicobacter pylori infections induce host cell inflammation and apoptosis, however, they are conflicting. tanshinone iia is an active compound of salvia miltiorrhiza bge. in this study, we investigated the regulatory effects of tanshinone iia on h. pylori-induced inflammation and apoptosis in vitro. tanshinone iia treatments (13.6-54.4[formula: see text][formula: see text]m) significantly decreased nuclear factor kappa b (nf-kb) and mitogen-activated protein kinase (mapk) [p-38 and c-terminal j ... | 2016 | 27627918 |
| potentiation activity of multiple antibacterial agents by salvianolate from the chinese medicine danshen against methicillin-resistant staphylococcus aureus (mrsa). | salvianolate (sal) is a prescribed medicine from the chinese herb danshen (salvia miltiorrhiza bunge). it has been widely used in treatment of coronary and other diseases with significant effects. the in vitro antimicrobial activities of sal against infectious pathogens were assayed and its combined effects on 10 clinical isolates of sccmec iii type methicillin-resistant staphylococcus aureus (mrsa) with ten antibiotics were evaluated. susceptibility to each agent alone was tested using a broth ... | 2016 | 26639445 |
| utilization and prescription patterns of traditional chinese medicine for patients with hepatitis c in taiwan: a population-based study. | to characterize the utilization of traditional chinese medicine (tcm) among patients with hepatitis c (hc). | 2016 | 27769222 |
| [effect of glomus versiforme and trichoderma harzianum on growth and quality of salvia miltiorrhiza]. | the present study aimed to investigate the effect of glomus versiforme and trichodema harzianum on the growth and quality of salvia miltiorrhiza continuous cropping under field conditions. the field plot experiment was conducted, these active components in the plant were analyzed by hplc, the root diseases incidence rate of s. miltiorrhiza determined by observation and counting, and relative parameters were measured. the data was statistically processed. the result showed that inoculation of g. ... | 2014 | 25095363 |
| first report of fingerprinting dried herbal products using a subtractive diversity array. | introduction sequence - independent microarrays have never been used to identify and authenticate dried herbal plants. | 2013 | 23828332 |
| genome-wide analysis, molecular cloning and expression profiling reveal tissue-specifically expressed, feedback-regulated, stress-responsive and alternatively spliced novel genes involved in gibberellin metabolism in salvia miltiorrhiza. | gibberellin (ga), a classical phytohormone, plays significant roles in plant growth and development. it shares the important intermediate diphosphate precursor, ggpp, with the main lipophilic bioactive components, diterpenoid tanshinones in salvia miltiorrhiza bunge, one of the most important traditional chinese medicine materials and an emerging model medicinal plant. analysis of ga metabolism and regulation may help to demonstrate the biological functions of gas and the crosstalk between ga me ... | 2015 | 26689421 |
| cytochrome p450 promiscuity leads to a bifurcating biosynthetic pathway for tanshinones. | cytochromes p450 (cyps) play a key role in generating the structural diversity of terpenoids, the largest group of plant natural products. however, functional characterization of cyps has been challenging because of the expansive families found in plant genomes, diverse reactivity and inaccessibility of their substrates and products. here we present the characterization of two cyps, cyp76ah3 and cyp76ak1, which act sequentially to form a bifurcating pathway for the biosynthesis of tanshinones, t ... | 2016 | 26682704 |
| molecular cloning and expression analysis of wrky transcription factor genes in salvia miltiorrhiza. | wrky proteins comprise a large family of transcription factors and play important regulatory roles in plant development and defense response. the wrky gene family in salvia miltiorrhiza has not been characterized. | 2015 | 25881056 |
| identification and characterization of mrna-like noncoding rnas in salvia miltiorrhiza. | identification and characterization of 5,446 mlncrnas from salvia miltiorrhiza showed that the majority of identified mlncrnas were stress responsive, providing a framework for elucidating mlncrna functions in s. miltiorrhiza. mrna-like noncoding rnas (mlncrnas) are transcribed by rna polymerase ii and are polyadenylated, capped and spliced. they play important roles in plant development and defense responses. however, there is no information available for mlncrnas in salvia miltiorrhiza bunge, ... | 2015 | 25601000 |
| increased accumulation of the cardio-cerebrovascular disease treatment drug tanshinone in salvia miltiorrhiza hairy roots by the enzymes 3-hydroxy-3-methylglutaryl coa reductase and 1-deoxy-d-xylulose 5-phosphate reductoisomerase. | tanshinone is widely used for treatment of cardio-cerebrovascular diseases with increasing demand. herein, key enzyme genes smhmgr (3-hydroxy-3-methylglutaryl coa reductase) and smdxr (1-deoxy-d-xylulose 5-phosphate reductoisomerase) involved in the tanshinone biosynthetic pathway were introduced into salvia miltiorrhiza (sm) hairy roots to enhance tanshinone production. over-expression of smhmgr or smdxr in hairy root lines can significantly enhance the yield of tanshinone. transgenic hairy roo ... | 2014 | 24913677 |
| [construction of saccharomyces cerevisiae whole-cell biocatalyst system for conversion miltiradiene]. | tanshinones are the bioactive components of the chinese medicinal herb salvia miltiorrhiza, while its biosynthetic pathway remains to be characterized. rapid identification and characterization of the genes correlated to tanshinones biosynthesis is very important. as one of the intermediates of tanshinones biosynthesis, the ferruginol content is relative low in both root and engineered bacteria. it is urgent to construct an efficient system for conversion of miltiradiene to ferruginol to obtain ... | 2013 | 24417091 |
| [study on the regulation role of semen persicae to camp-pka signal pathway in the rats with cold and heat blood stasis syndrome]. | to study the regulation role of with neutral property to camp-pka pathway in the rats with cold and heat blood stasis syndromes and it's mechanism. | 2013 | 24218973 |
| effects and mechanisms of compound chinese medicine and major ingredients on microcirculatory dysfunction and organ injury induced by ischemia/reperfusion. | microcirculation dysfunction and organ injury after ischemia and reperfusion (i/r) result from a complex pathologic process consisting of multiple links, with metabolism impairment in the ischemia phase and oxidative stress in the reperfusion phase as initiators, and any treatment targeting a single link is insufficient to cope with this. compound chinese medicine (ccm) has been applied in clinics in china and some asian nations for more than 2000 years. studies over the past decades revealed th ... | 2017 | 28322971 |
| chinese herbal drugs for the treatment of diabetic retinopathy. | to explore the various pharmacological actions and the molecular mechanisms behind them by which chinese herbs tend to lower the risk of developing microvascular diabetic complications in retina and prevent its further progression. | 2017 | 28124440 |
| neuroprotective effect of a novel chinese herbal decoction on cultured neurons and cerebral ischemic rats. | historically, traditional chinese medicine has been widely used to treat stroke. based on the theory of chinese medicine and the modern pharmacological knowledge of herbal medicines, we have designed a neuroprotective formula called post-stroke rehabilitation (psr), comprising seven herbs - astragalus membranaceus (fisch.) bunge, salvia miltiorrhiza bunge, paeonia lactiflora pall., cassia obtusifolia l., ligusticum chuanxiong hort., angelica sinensis (oliv.) diels, and glycyrrhiza uralensis fisc ... | 2016 | 27814708 |
| improved survival with integration of chinese herbal medicine therapy in patients with acute myeloid leukemia: a nationwide population-based cohort study. | purpose acute myeloid leukemia (aml) is the most deadly subtype of leukemia, and many patients with this disease seek other complementary therapies, one of which is chinese medicine. we set out to provide reliable data regarding the benefit of chinese herbal medicine (chm) for aml patients, using mortality as the main outcome measure. we also characterized the herbal prescriptions of patients. methods using the taiwanese national health insurance research database, we performed a nationwide popu ... | 2016 | 27531548 |
| a combination of the main constituents of fufang xueshuantong capsules shows protective effects against streptozotocin-induced retinal lesions in rats. | fufang xueshuantong capsule, an herbal formula licensed for clinical use in china, which is composed of panax notoginseng (burkill) f.h. chen, salvia miltiorrhiza bunge, astragalus membranaceus (fisch.) bunge, and scrophularia ningpoensis hemsl, has proven effective for the treatment of diabetic retinopathy. however, its bioactive constituents are still ambiguous. in this study, the therapeutic effects of a combination of the main constituents of fufang xueshuantong capsule (cfxt) were evaluated ... | 2016 | 26692279 |
| [formula optimization in renshen jianxin capsule based on uniform design and anti-myocardial ischemia effect]. | to realize quadratic formula optimization of renshen jianxin capsule (rjc) by screening chinese herbs with major anti-myocardial ischemia effect in rjc and optimize their optimal dosages. | 2015 | 26591367 |
| qishenyiqi dropping pill attenuates myocardial fibrosis in rats by inhibiting raas-mediated arachidonic acid inflammation. | in china, qishenyiqi dropping pill (qsdp), a chinese medicine formula containing astragalus membranaceus (fisch.) bunge, salvia miltiorrhiza bunge, panax notoginseng (burkill) f.h.chen and dalbergia odorifera t.c.chen, has been used frequently in traditional folk medicine for treatment of coronary heart diseases (chd) and heart failure (hf). | 2015 | 26590099 |
| the antithrombotic effect of rsnk in blood-stasis model rats. | reduction of sheng-nao-kang decoction (rsnk), composed of salvia miltiorrhiza bge., ligusticum chuanxiong hort., astragalus membranaceus (fisch.) bunge., pueraria lobata (willd.) ohwi., paeonia lactiflora pall. and panax notoginseng (burk.) f. h. chen., is a modified traditional chinese medicinal formula of sheng-nao-kang pill preparation, which has been investigated its protective effect on focal cerebral ischemia-reperfusion injury in rat in our previous report. | 2015 | 26216512 |
| effect of shenkang granules on the progression of chronic renal failure in 5/6 nephrectomized rats. | shenkang granules (skgs) are a chinese herbal medicinal formula, consisting of rhubarb (rheum palmatum l.), salvia miltiorrhiza, milkvetch root [astragalus membranaceus (fisch.) bunge] and safflower (carthamus tinctorius l.). the aim of the present study was to investigate the effect of skg on chronic renal failure (crf) in 5/6 nephrectomized (5/6 nx) rats. the rats were randomly divided into seven groups (n=10 per group) as follows: (i) 5/6 nx (model group; 2.25 ml/kg/day normal saline); (ii) s ... | 2015 | 26136932 |
| compound astragalus and salvia miltiorrhiza extracts modulate mapk-regulated tgf-β/smad signaling in hepatocellular carcinoma by multi-target mechanism. | astragalus membranaceus bunge (leguminosae) and salvia miltiorrhiza bunge (lamiaceae) are two important chinese herbs with a long history of extensive ethnobotanical usage in the treatment of liver-related diseases over many centuries. presently, these two herbs are being used either as a single herbal formulation or a composite formula for the treatment of liver related conditions. in response, recent studies on these two herbs have focused on elucidating their mechanisms of action, particularl ... | 2015 | 25934513 |
| molecular signalings in keloid disease and current therapeutic approaches from natural based compounds. | keloid is an excessive dermal scar occurring in response to skin injuries. several therapeutic strategies have been proposed to ease the aggressiveness of keloid scarring. even though the principle mechanism underlying the disease propagation still remains unidentified, several signaling pathways were highly focused as plausible pathways involving keloid formation, including transforming growth factor-beta 1 (tgf-β1), mitogen-activated protein kinase (mapk), insulin-like growth factor-i (igf-i), ... | 2015 | 25331681 |
| [cloning and bioinformatics analysis of smnac1 from salvia miltiorrhiza hairy root]. | in order to study function of nac transcription in development, hormone regulation and the stress response of salvia miltiorrhiza, the nac transcription was cloned and analyzed. by retrieving cdna database of s. miltiorrhiza hairy root one nac unigene was found, then a full length of cdna was cloned by designing specific primers and pcr amplifying. using orf finder it was found that the cdna containing a nac-ab conserved domain in n-terminal, so the cdna was a nac transcription factor, named as ... | 2013 | 24079226 |
| compound astragalus and salvia miltiorrhiza extracts suppress hepatocarcinogenesis by modulating transforming growth factor-β/smad signaling. | previous studies showed compound astragalus and salvia miltiorrhiza extract (case), extract from astragalus membranaceus and salvia miltiorhiza, significantly suppresses hepatocellular carcinoma (hcc) in rats induced by diethylinitrosamine (den), and in vitro experiments further demonstrated that case's anti-hepg2 cell invasion is associated with transforming growth factor-β (tgf-β). we hypothesized that case's suppression of hcc is modulated by tgf-β/smad signaling, and we conducted this in viv ... | 2014 | 24329763 |
| compound astragalus and salvia miltiorrhiza extract suppresses hepatocellular carcinoma progression by inhibiting fibrosis and pai-1 mrna transcription. | astragalus membranaceus and salvia miltiorrhiza have been used for centuries in china to treat liver diseases. previous studies have shown that these herbs and their extracts inhibit the development of liver fibrosis and the proliferation and invasion of human hepatoma hepg2 cells. further study of their pharmacological effects on hepatocellular carcinoma (hcc) is needed. to investigate the effects of compound astragalus and salvia miltiorrhiza extract (case) on diethylinitrosamine (den)-induced ... | 2014 | 24247078 |
| the role of traditional chinese medicines in osteogenesis and angiogenesis. | the article aims to review various traditional chinese medicines (tcms) with both osteogenic and angiogenic effects, alone and in combination, and to consider whether these tcms promote osteogenesis via angiogenesis and vascular endothelial growth factor (vegf). each of the tcms involving in osteogenesis was searched through pubmed and cbmdisc using its latin name and english name, and keywords such as 'osteogenesis', 'bone', 'osteoblast', 'angiogenesis', 'vegf' were used. a total of 241 article ... | 2014 | 23494901 |
| metabolite profiling and pharmacokinetics of herbal compounds following oral administration of a cardiovascular multi-herb medicine (qishen yiqi pills) in rats. | qishen yiqi pills (qy pills) are a type of standardized cardiovascular herbal medicine, which contain four component herbs, i.e., astragalus membranaceus (huangqi), salvia miltiorrhiza (danshen), panax notoginseng (sanqi), and dalbergia odorifera (jiangxiang). after oral administration of qy pills, the in vivo exposure types of each component herb in rats were first uncovered and identified according to a target-directed strategy based on hyphenated chromatography techniques. the dominated metab ... | 2012 | 22292791 |
| biological analysis of herbal medicines used for the treatment of liver diseases. | herbal medicines have been used to treat liver disorders for thousands of years in the east and have now become a promising therapy internationally for pathological liver conditions. biological analysis of hepatoprotective herbs is an important issue from the pharmacokinetic perspective in developing new therapeutic managements for liver disease. the biological analysis focuses on the pretreatment methods, separation and quantification of herbal medicines in biological samples. we have compiled ... | 2011 | 21204110 |
| myelophil, an extract mix of astragali radix and salviae radix, ameliorates chronic fatigue: a randomised, double-blind, controlled pilot study. | to investigate the anti-fatigue effects of myelophil, an extract of a mix of astragali radix and salviae radix, which has been used to treat patients with chronic fatigue. | 2009 | 19398067 |
| [influence of salvia miltiorrhizae and astragalus membranaceus on hemodynamics and liver fibrosis indexes in liver cirrhotic patients with portal hypertension]. | to observe the influence of salvia miltiorrhiza (sm) and astragalus membranaceus (am) on hemodynamics and liver fibrosis indexes in patients of liver cirrhosis with portal hypertension. | 2001 | 12577420 |
| [cloning and bioinformatics analysis of chorismate mutase gene from salvia miltiorrhiza]. | chorismate mutase catalyzes the conversion of chorismate to prephenate that is the first committed step in the biosynthesis of the aromatic amino acids phenylalanine and tyrosine. a chorismate mutase gene, designated smcm1, was isolated from salvia miltiorrhiza by using rt-pcr. the full length of smcm1 cdna consists of 948 nucleotides and has an open reading frame of 765 bp. the deduced amino acid sequence of smcm1 has 255 amino acid residues which forms a 36.0 kd polypeptide with calculated pi ... | 2013 | 24010280 |
| effects of combined elicitors on tanshinone metabolic profiling and smcps expression in salvia miltiorrhiza hairy root cultures. | tanshinones are abietane-type norditerpenoid quinone natural products found in a well-known traditional chinese medicinal herb, salvia miltiorrhiza bunge. the copalyl diphosphate synthase of s. miltiorrhiza (smcps) is the key enzyme in the first step for transformation of geranylgeranyl diphosphate (ggpp) into miltiradiene, which has recently been identified as the precursor of tanshinones. based on previous gene-to-metabolite network, this study examined the influences of various combined elici ... | 2013 | 23807574 |
| elucidating the influence of gold nanoparticles on the binding of salvianolic acid b and rosmarinic acid to bovine serum albumin. | salvianolic acid b and rosmarinic acid are two main water-soluble active ingredients from salvia miltiorrhiza with important pharmacological activities and clinical applications. the interactions between salvianolic acid b (or rosmarinic acid) and bovine serum albumin (bsa) in the presence and absence of gold nanoparticles (au nps) with three different sizes were investigated by using biophysical methods for the first time. experimental results proved that two components quenched the fluorescenc ... | 2015 | 25861047 |
| [experimental study on two-way application of drugs with neutral property for promoting blood circulation and removing blood stasis on cold and heat blood stasis syndromes ii]. | to further study the characteristics of drugs with neutral property in two-way application and conditioned dominance by observing the action characteristic of 10 traditional chinese medicines with neutral property in hemorheological indicators of heat stagnation and blood stasis syndrome and cold stagnation and blood stasis syndrome rats. | 2013 | 23713291 |
| in vitro fabrication of dental filling nanopowder by green route and its antibacterial activity against dental pathogens. | the aim of this study was to introduce novel sn, cu, hg, and ag nanopowders (nps) and a composite nanopowder (np) synthesized using salvia miltiorrhiza bunge (sm) root extract as a reducing and capping agent to improve the antibacterial property of dental filling materials. all of the nps obtained were characterized using a scanning transmission electron microscope (stem), and energy dispersive x-ray (edx) spectrum imaging was performed to map the elemental distributions of the np composite. fou ... | 2016 | 27085055 |
| sodium tanshinone iia sulfonate inhibits porcine reproductive and respiratory syndrome virus via suppressing n gene expression and blocking virus-induced apoptosis. | porcine reproductive and respiratory syndrome virus (prrsv) causes significant economic loss in the swine industry. currently, there is no effective way to prevent prrsv infection. sodium tanshinone iia sulfonate (sts), a natural compound derived from salvia miltiorrhiza, was shown to possess anti-prrsv activity, but the underlying mechanisms remain unclear. the objective of this study was to investigate the effect of sts on prrsv-induced cell apoptosis and prrsv n protein expression pattern. | 2014 | 24158620 |
| synergistic cardioprotective effects of danshensu and hydroxysafflor yellow a against myocardial ischemia-reperfusion injury are mediated through the akt/nrf2/ho-1 pathway. | in clinical practice, the traditional chinese medicinal herbs, radix salvia miltiorrhiza and carthamus tinctorius l., are usually prescribed in combination due to their significant cardioprotective effects. however, the mechanisms responsible for these combined effects remain unknown. thus, in this study, we investigated the mechanisms responsible for the combined effects of danshensu (dss) and hydroxysafflor yellow a (hsya) by establishing a rat model of myocardial ischemia/reperfusion (mi/r), ... | 2016 | 27176815 |
| the mixture of salvia miltiorrhiza-carthamus tinctorius (danhong injection) alleviates low-dose aspirin induced gastric mucosal damage in rats. | danhong injection (dhi) is quite often used in combination with low-dose aspirin (asa, 75-325mg daily) in clinic, particularly for the treatment of cardiovascular diseases. exploring their interaction profile is of great clinical importance. | 2016 | 27161407 |
| danhong injection attenuates isoproterenol-induced cardiac hypertrophy by regulating p38 and nf-κb pathway. | danhong injection (dhi), derived from rhizoma salviae miltiorrhizae (salvia miltiorrhiza bge., labiatae, danshen in chinese) and flos carthami (carthamus tinctorius l., compositae, salvia militiorrhiza bunge), is an extensively-used chinese material standardized clinical product for treatment of cardiovascular diseases. | 2016 | 26970569 |
| bioactive alkaloids produced by pseudomonas brassicacearum subsp. neoaurantiaca, an endophytic bacterium from salvia miltiorrhiza. | eleven compounds were isolated from the culture of an endophytic bacterium pseudomonas brassicacearum subsp. neoaurantiaca in salvia miltiorrhiza bunge. their structures were elucidated by spectroscopic methods as cyclo-(gly-l-ala) (1), cyclo-(l-ala-l-ala) (2), cyclo-(l-pro-gly) (3), cyclo-(l-pro-l-ser) (4), cyclo-(l-ala-trans-4-hydroxy-l-pro) (5), cyclo-(l-val-l-pro) (6), cyclo-(gly-l-tyr) (7), cyclo-(l-ala-l-tyr) (8), cyclo-(l-tyr-trans-4-hydroxy-l-pro) (9), 3-methylhydantoin (10) and 2-piperi ... | 2013 | 22765159 |
| characterization of the polyphenol oxidase gene family reveals a novel microrna involved in posttranscriptional regulation of ppos in salvia miltiorrhiza. | salvia miltiorrhiza is a well-known material of traditional chinese medicine. understanding the regulatory mechanisms of phenolic acid biosynthesis and metabolism are important for s. miltiorrhiza quality improvement. we report here that s. miltiorrhiza contains 19 polyphenol oxidases (ppos), forming the largest ppo gene family in plant species to our knowledge. analysis of gene structures and sequence features revealed the conservation and divergence of smppos. smppos were differentially expres ... | 2017 | 28304398 |
| comparative proteomic analysis of the response to silver ions and yeast extract in salvia miltiorrhiza hairy root cultures. | biotic and abiotic stresses can inhibit plant growth, resulting in losses of crop productivity. however, moderate adverse stress can promote the accumulation of valuable natural products in medicinal plants. elucidating the underlying molecular mechanisms thus might help optimize the variety of available plant medicinal materials and improve their quality. in this study, salvia miltiorrhiza hairy root cultures were employed as an in vitro model of the chinese herb danshen. a comparative proteomi ... | 2016 | 27372730 |
| functional characterization of ent-copalyl diphosphate synthase, kaurene synthase and kaurene oxidase in the salvia miltiorrhiza gibberellin biosynthetic pathway. | salvia miltiorrhiza bunge is highly valued in traditional chinese medicine for its roots and rhizomes. its bioactive diterpenoid tanshinones have been reported to have many pharmaceutical activities, including antibacterial, anti-inflammatory, and anticancer properties. previous studies found four different diterpenoid biosynthetic pathways from the universal diterpenoid precursor (e,e,e)-geranylgeranyl diphosphate (ggpp) in s. miltiorrhiza. here, we describe the functional characterization of e ... | 2016 | 26971881 |
| tanshinones extend chronological lifespan in budding yeast saccharomyces cerevisiae. | natural products with anti-aging property have drawn great attention recently but examples of such compounds are exceedingly scarce. by applying a high-throughput assay based on yeast chronological lifespan measurement, we screened the anti-aging activity of 144 botanical materials and found that dried roots of salvia miltiorrhiza bunge have significant anti-aging activity. tanshinones isolated from the plant including cryptotanshione, tanshinone i, and tanshinone iia, are the active components. ... | 2014 | 24970458 |
| cyp76ah1 catalyzes turnover of miltiradiene in tanshinones biosynthesis and enables heterologous production of ferruginol in yeasts. | cytochrome p450 enzymes (cyps) play major roles in generating highly functionalized terpenoids, but identifying the exact biotransformation step(s) catalyzed by plant cyp in terpenoid biosynthesis is extremely challenging. tanshinones are abietane-type norditerpenoid naphthoquinones that are the main lipophilic bioactive components of the chinese medicinal herb danshen (salvia miltiorrhiza). whereas the diterpene synthases responsible for the conversion of (e,e,e)-geranylgeranyl diphosphate into ... | 2013 | 23812755 |
| regulation of water-soluble phenolic acid biosynthesis in salvia miltiorrhiza bunge. | salvia miltiorrhiza bunge (lamiaceae) root, generally called danshen, is an important herb in chinese medicine widely used for treatment of various diseases. phenolic acids in s. miltiorrhiza, as important effective compounds, have become a new research focus in plant secondary metabolism in recent years. this review summarizes the recent advances in the regulation of water-soluble phenolic acid biosynthesis in s. miltiorrhiza via regulators at molecular level, such as the phenylalanine ammonia- ... | 2013 | 23673485 |
| antioxidant and anti-inflammatory activities of selected chinese medicinal plants and their relation with antioxidant content. | the main aim of this study is to evaluate the antioxidant and anti-inflammatory properties of forty four traditional chinese medicinal herbal extracts and to examine these activities in relation to their antioxidant content. | 2012 | 23038995 |
| [isolation and characteristic of smbhlh1 gene in salvia miltiorrhiza]. | a novel bhlh-like gene, designated smbhlh1, was isolated from salvia miltiorrhiza, in order to identify a bhlh gene in related to danshinone biosysnthesis. | 2011 | 22368847 |
| modular pathway engineering of diterpenoid synthases and the mevalonic acid pathway for miltiradiene production. | microbial production can be advantageous over the extraction of phytoterpenoids from natural plant sources, but it remains challenging to rationally and rapidly access efficient pathway variants. previous engineering attempts mainly focused on the mevalonic acid (mva) or methyl-d-erythritol phosphate (mep) pathways responsible for the generation of precursors for terpenoids biosynthesis, and potential interactions between diterpenoids synthases were unexplored. miltiradiene, the product of the s ... | 2012 | 22280121 |
| elicitors from the endophytic fungus trichoderma atroviride promote salvia miltiorrhiza hairy root growth and tanshinone biosynthesis. | biotic elicitors can be used to stimulate the production of secondary metabolites in plants. however, limited information is available on the effects of biotic elicitors from endophytic fungi on their host plant. trichoderma atroviride d16 is an endophytic fungus isolated from the root of salvia miltiorrhiza and previously reported to produce tanshinone i (t-i) and tanshinone iia (t-iia). here, the effects of extract of mycelium (em) and the polysaccharide fraction (psf), produced by t. atroviri ... | 2013 | 24127517 |
| antioxidant activity of 45 chinese herbs and the relationship with their tcm characteristics. | here, 45 chinese herbs that regulate blood circulation were analyzed for antioxidant activity using the oxygen radical absorbance capacity (orac) assay. a recent publication by ou et al. identified a close relationship between in vitro antioxidant activity and classification of chinese herbs as yin or yang. the 45 chinese herbs in this study could be assigned the traditional characteristics of natures (cold, cool, hot and warm), flavors (pungent, sweet, sour, bitter and salty) and functions (arr ... | 2008 | 18955214 |
| herbs and dietary supplements in the prevention and treatment of cardiovascular disease. | herbs and dietary supplements can have significant physiological effects. garlic (allium sativum) has shown beneficial lipid effects in a majority of trials; dried garlic preparations are superior to oil preparations. there is preliminary evidence that indicates that hawthorn (crataegus species) may provide benefits in congestive heart failure. coenzyme q also may be of benefit in congestive heart failure. although observational studies indicate a protective effect of dietary or supplemental vit ... | 2000 | 11834913 |
| identification of symmetrical rna editing events in the mitochondria of salvia miltiorrhiza by strand-specific rna sequencing. | salvia miltiorrhiza is one of the most widely-used medicinal plants. here, we systematically analyzed the rna editing events in its mitochondria. we developed a pipeline using reditools to predict rna editing events from stand-specific rna-seq data. the predictions were validated using reverse transcription, rt-pcr amplification and sanger sequencing experiments. putative sequences motifs were characterized. comparative analyses were carried out between s. miltiorrhiza, arabidopsis thaliana and ... | 2017 | 28186130 |
| overexpression of atedt1 promotes root elongation and affects medicinal secondary metabolite biosynthesis in roots of transgenic salvia miltiorrhiza. | medicinal secondary metabolites (salvianolic acids and tanshinones) are valuable natural bioactive compounds in salvia miltiorrhiza and have widespread applications. improvement of medicinal secondary metabolite accumulation through biotechnology is necessary and urgent to satisfy their increasing demand. herein, it was demonstrated that the overexpression of the transcription factor arabidopsis thaliana-enhanced drought tolerance 1 (atedt1) could affect medicinal secondary metabolite accumulati ... | 2016 | 27915455 |
| ectopic expression of dreb transcription factor, atdreb1a, confers tolerance to drought in transgenic salvia miltiorrhiza. | drought decreases crop productivity more than any other type of environmental stress. transcription factors (tfs) play crucial roles in regulating plant abiotic stress responses. the arabidopsis thaliana gene dreb1a/cbf3, encoding a stress-inducible tf, was introduced into salvia miltiorrhiza ectopic expression of atdreb1a resulted in increased drought tolerance, and transgenic lines had higher relative water content and chl content, and exhibited an increased photosynthetic rate when subjected ... | 2016 | 27485523 |
| arabidopsis dreb1b in transgenic salvia miltiorrhiza increased tolerance to drought stress without stunting growth. | multiple stress response genes are controlled by transcription factors in a coordinated manner; therefore, these factors can be used for molecular plant breeding. cbf1/dreb1b, a known stress-inducible gene, was isolated from arabidopsis thaliana and introduced into salvia miltiorrhiza under the control of the camv35s or rd29a promoter. under drought stress, relative water content, chlorophyll content, and the net photosynthetic rate were observed to be higher in the transgenic lines than in the ... | 2016 | 27002402 |
| enhanced diterpene tanshinone accumulation and bioactivity of transgenic salvia miltiorrhiza hairy roots by pathway engineering. | tanshinones are health-promoting diterpenoids found in salvia miltiorrhiza and have wide applications. here, smggpps (geranylgeranyl diphosphate synthase) and smdxsii (1-deoxy-d-xylulose-5-phosphate synthase) were introduced into hairy roots of s. miltiorrhiza. overexpression of smggpps and smdxsii in hairy roots produces higher levels of tanshinone than control and single-gene transformed lines; tanshinone production in the double-gene transformed line gdii10 reached 12.93 mg/g dry weight, whic ... | 2016 | 26753746 |
| a network pharmacology study of chinese medicine qishenyiqi to reveal its underlying multi-compound, multi-target, multi-pathway mode of action. | chinese medicine is a complex system guided by traditional chinese medicine (tcm) theories, which has proven to be especially effective in treating chronic and complex diseases. however, the underlying modes of action (moa) are not always systematically investigated. herein, a systematic study was designed to elucidate the multi-compound, multi-target and multi-pathway moa of a chinese medicine, qishenyiqi (qsyq), on myocardial infarction. qsyq is composed of astragalus membranaceus (huangqi), s ... | 2014 | 24817581 |
| [regularity of drug use of patents in force of traditional chinese medicine compounds in preventing and treating cardiovascular diseases on basis of frequency analysis]. | to study the regularity of drug use of patents in force of traditional chinese medicine compounds in treating cardiovascular diseases and provide reference for new drug r&d and patent protection. | 2012 | 23236773 |
| [study of chinese herbal medicine in treating ascites and their mechanism in regulating lymphatic stomata]. | to study the therapeutic effect of chinese herbal medicines (chm) in treating ascites to elucidate its mechanism in regulating the lymphatic stomata and promoting the absorption of ascites from the peritoneal cavity. | 2001 | 12575556 |
| salvia miltiorrhiza injection restores apoptosis of fibroblast-like synoviocytes cultured with serum from patients with rheumatoid arthritis. | salvia miltiorrhiza injection (smi) is a water‑soluble agent, derived from salvia miltiorrhiza (sm), that is traditionally used to treat cardiovascular and cerebrovascular diseases. furthermore it has been demonstrated to possess the ability to induce apoptosis of tumor cells. however, it remains unclear whether smi can induce apoptosis of rheumatoid arthritis (ra) fibroblast‑like synoviocytes (fls), which are hyperplastic in ra due to defective apoptosis. there is also evidence that allogenic s ... | 2015 | 25352238 |
| renoprotection of danshen injection on streptozotocin-induced diabetic rats, associated with tubular function and structure. | danshen injection, the aqueous extracts of radix salvia miltiorrhiza (s. miltiorrhiza), is one of the most commonly used traditional chinese herbs in chronic renal failure treatment. in present study, the mechanism of the renoprotective effect of danshen injection was analyzed on streptozocin (stz)-induced diabetic rats. | 2014 | 24269771 |
| herbal medicines for fatty liver diseases. | fatty liver disease is potentially a reversible condition that may lead to end-stage liver disease. since herbal medicines such as crataegus pinnatifida and salvia miltiorrhiza have increasingly been used in the management of fatty liver disease, a systematic review on herbal medicine for fatty liver disease is needed. | 2013 | 23975682 |
| danhong injection protects cardiomyocytes against hypoxia/reoxygenation- and h2o2-induced injury by inhibiting mitochondrial permeability transition pore opening. | danhong injection (dhi), a chinese medical product extracted from radix et rhizoma salviae miltiorrhizae (salvia miltiorrhiza bge., labiatae, danshen in chinese) and flos carthami (carthamus tinctorius l., compositae, honghua in chinese), has been widely used for the treatment of ischemic heart disease, and clinical and experimental studies have demonstrated the protective effects against myocardial ischemia/reperfusion injury. nevertheless, the underlying cellular mechanisms responsible for thi ... | 2015 | 26320687 |
| protective effect of salvia miltiorrhiza and carthamus tinctorius extract against lipopolysaccharide-induced liver injury. | to investigate the hepatoprotective effects and mechanisms of an extract of salvia miltiorrhiza and carthamus tinctorius in vivo. | 2015 | 26290634 |
| formula optimization of the jiashitang scar removal ointment and antiinflammatory compounds screening by nf-κb bioactivity-guided dual-luciferase reporter assay system. | inflammation plays a role in scar formation; therefore, decreasing inflammation benefits scar removal. jiashitang scar removal ointment (jst) is a commercially available traditional chinese medicinal formulation. it is composed of extracts from carthamus tinctorius l. (car), rheum officinale baill. (rhe), salvia miltiorrhiza beg. (sal), and panax notoginseng (burk.) f. h. chen (pan), which are all herbs with potent antiinflammatory activities. our aims are to optimize the formula of jst and to e ... | 2015 | 25363818 |
| lipid-lowering effects of danhong injection on hyperlipidemia rats. | danhong injection (dhi), a chinese medical product extracted from radix et rhizoma salviae miltiorrhizae (salvia miltiorrhiza bge., labiatae, danshen in chinese) and flos carthami (carthamus tinctorius l., compositae, honghua in chinese), has been reported to have anti-inflammatory, anti-oxidative and anti-fibrinolytic properties and is used extensively for the clinical treatment of cardiovascular disease in clinic. this study aimed to investigate the preventive and therapeutic effects of dhi on ... | 2014 | 24751362 |
| [on-line monitoring of extraction process of danhong injection based on near-infrared spectroscopy]. | to establish a rapid quantitative analysis method for the quality control of danhong injection extraction using near-infrared (nir) spectroscopy. | 2013 | 24010271 |
| amelioration of danhong injection on the lipopolysaccharide-stimulated systemic acute inflammatory reaction via multi-target strategy. | systemic inflammatory response syndrome (sirs), leading to dire consequences, is a serious and fatal disease in clinic. danhong injection (dhi), one of the most popular medications for coronary heart disease and cerebral ischemia, plays pharmacological actions through inhibiting local inflammation. nevertheless, the anti-inflammatory effect of dhi has not been reported before and has not been fully clarified. | 2013 | 23954279 |
| preventive and therapeutic effects of danhong injection on lipopolysaccharide induced acute lung injury in mice. | danhong injection (dhi), a chinese materia medica standardized product extracted from radix et rhizoma salviae miltiorrhizae (salvia miltiorrhiza bge., labiatae, danshen in chinese) and flos carthami (carthamus tinctorius l., compositae, honghua in chinese), has been reported to have anti-inflammatory, anti-oxidative and anti-fibrinolytic properties, which is used extensively for the treatment of cardiovascular diseases in clinic. | 2013 | 23850708 |
| reactive oxygen species scavenging activity of jixueteng evaluated by electron spin resonance (esr) and photon emission. | jixueteng, the dried stem of spatholobus suberectus dunn (leguminosae), is a traditional chinese herbal medicine that is commonly classified as a herb that promotes blood circulation and can be used to treat blood stasis. the aim of this study was to examine the reactive oxygen species (ros) scavenging activity of jixueteng and other herbal medicines. the ros scavenging activities of the water extracts of jixueteng, cnidium officinale and salvia miltiorrhiza were examined using an electron spin ... | 2014 | 25632478 |
| the herbal extract kcho-1 exerts a neuroprotective effect by ameliorating oxidative stress via heme oxygenase-1 upregulation. | kcho-1 is a novel product comprised of 30% ethanol extracts obtained from nine medical herbs, which are commonly used in traditional korean and chinese medicine. the nine herbs include curcuma longa, salvia miltiorrhiza, gastrodia elata, chaenomeles sinensis, polygala tenuifolia, paeonia japonica, glycyrrhiza uralensis, atractylodes japonica and processed aconitum carmichaeli. recent studies have reported the beneficial effects of these herbs. the present study aimed to investigate the direct ne ... | 2016 | 27082826 |
| brain food for alzheimer-free ageing: focus on herbal medicines. | healthy brain aging and the problems of dementia and alzheimer's disease (ad) are a global concern. beyond 60 years of age, most, if not everyone, will experience a decline in cognitive skills, memory capacity and changes in brain structure. longevity eventually leads to an accumulation of amyloid plaques and/or tau tangles, including some vascular dementia damage. therefore, lifestyle choices are paramount to leading either a brain-derived or a brain-deprived life. the focus of this review is t ... | 2015 | 26092628 |