| new evaluation vector through the stanford mobile inquiry-based learning environment (smile) for participatory action research. | this article reviews an evaluation vector model driven from a participatory action research leveraging a collective inquiry system named smile (stanford mobile inquiry-based learning environment). | 2016 | 27525157 |
| 2015 outbreak of zika virus disease declared as public health emergency of international concern: justification, consequences, and the public health perspective. | | 2016 | 27904600 |
| cytojournal quiz cases: publishing open-access, pubmed-searchable cytopathology cases with educational messages. | | 2016 | 27563338 |
| natural and synthetic neurotoxins in our environment: from alzheimer's disease (ad) to autism spectrum disorder (asd). | | 2016 | 27747136 |
| a sequence of flushing and drying of breeding habitats of aedes aegypti (l.) prior to the low dengue season in singapore. | in dengue-endemic areas, transmission shows both a seasonal and interannual variability. to investigate how rainfall impacts dengue seasonality in singapore, we carried out a longitudinal survey in the geylang neighborhood from august 2014 to august 2015. the survey comprised of twice-weekly random inspections to outdoor breeding habitats and continuous monitoring for positive ones. in addition, observations of rainstorms were collected. out of 6824 inspected habitats, 67 contained aedes aegypti ... | 2016 | 27459322 |
| finding clues for congenital zika syndrome: zika virus selective infection of immature neurons. | | 2016 | 27475896 |
| virus genomics and evolution: the transformative effect of new technologies and multidisciplinary collaboration on virus research and outbreak management. | the first virus genomics and evolution conference was held at the wellcome genome campus in hinxton, uk, 8-10 june 2016. | 2016 | 27457219 |
| three atypical lethal cases associated with acute zika virus infection in suriname. | acute zika virus infection usually presents with a self-limiting triad of fever, rash and arthritis. there is limited information on severe or lethal cases. we report three cases of lethal acute zika infection, confirmed with polymerase chain reaction, in adult patients with some co-morbidities. the patients showed rapid clinical deterioration with hemorrhagic and septic shock, and exaggerated acute and innate inflammatory responses with pronounced coagulopathy, and died soon after admission to ... | 2016 | 27630820 |
| mitonuclear interactions, mtdna-mediated thermal plasticity, and implications for the trojan female technique for pest control. | pest species pose major challenges to global economies, ecosystems, and health. unfortunately, most conventional approaches to pest control remain costly, and temporary in effect. as such, a heritable variant of the sterile insect technique (sit) was proposed, based on the introduction of mitochondrial dna mutations into pest populations, which impair male fertility but have no effects on females. evidence for this "trojan female technique" (tft) was recently provided, in the form of a mutation ... | 2016 | 27443488 |
| search.biopreprint: a discovery tool for cutting edge, preprint biomedical research articles. | the time it takes for a completed manuscript to be published traditionally can be extremely lengthy. article publication delay, which occurs in part due to constraints associated with peer review, can prevent the timely dissemination of critical and actionable data associated with new information on rare diseases or developing health concerns such as zika virus. preprint servers are open access online repositories housing preprint research articles that enable authors (1) to make their research ... | 2016 | 27508060 |
| zika virus infection in pregnant women in honduras: study protocol. | although there is increasing evidence for a relationship between symptomatic zika virus (zikv) maternal infection, and microcephaly, a firm causal relation has yet to be established by epidemiologic studies. studies also need to be conducted in recently infected settings. our objectives are to assess the frequency of zikv infection during pregnancy in honduras and the association of microcephaly with zikv infection. | 2016 | 27423687 |
| the epidemiology and transmissibility of zika virus in girardot and san andres island, colombia, september 2015 to january 2016. | transmission of zika virus (zikv) was first detected in colombia in september 2015. as of april 2016, colombia had reported over 65,000 cases of zika virus disease (zvd). we analysed daily surveillance data of zvd cases reported to the health authorities of san andres and girardot, colombia, between september 2015 and january 2016. zvd was laboratory-confirmed by reverse transcription-polymerase chain reaction (rt-pcr) in the serum of acute cases within five days of symptom onset. we use daily i ... | 0 | 27452806 |
| news feature: crucial role of belowground biodiversity. | | 0 | 27407141 |
| prospects and challenges of crispr/cas genome editing for the study and control of neglected vector-borne nematode diseases. | neglected tropical diseases caused by parasitic nematodes inflict an immense health and socioeconomic burden throughout much of the developing world. current estimates indicate that more than two billion people are infected with nematodes, resulting in the loss of 14 million disability-adjusted life years per annum. although these parasites cause significant mortality, they primarily cause chronic morbidity through a wide range of severe clinical ailments. treatment options for nematode infectio ... | 2016 | 27300487 |
| bringing next-generation diagnostics to the clinic through synthetic biology. | | 2016 | 27402339 |
| ultrastructure of zika virus particles in cell cultures. | zika virus (zikv) has infected thousands of brazilian people and spread to other american countries since 2015. the introduction of zikv brought a strong impact to public health in brazil. it is of utmost importance to identify a susceptible cell line that will enable the isolation and identification of the virus from patient samples, viral mass production, and testing of drug and vaccine candidates. besides real-time reverse transcriptase polymerase chain reaction diagnosis for detecting the vi ... | 2016 | 27581122 |
| zika virus: where is the treatment? | | 2016 | 27547128 |
| metarhizium brunneum blastospore pathogenesis in aedes aegypti larvae: attack on several fronts accelerates mortality. | aedes aegypti is the vector of a wide range of diseases (e.g. yellow fever, dengue, chikungunya and zika) which impact on over half the world's population. entomopathogenic fungi such as metarhizium anisopliae and beauveria bassiana have been found to be highly efficacious in killing mosquito larvae but only now are the underlying mechanisms for pathogenesis being elucidated. recently it was shown that conidia of m. anisopliae caused stress induced mortality in ae. aegypti larvae, a different mo ... | 2016 | 27389584 |
| the precautionary principle, evidence-based medicine, and decision theory in public health evaluation. | the precautionary principle (pp) has been used in the evaluation of the effectiveness and/or cost-effectiveness of interventions designed to prevent future harms in a range of activities, particularly in the area of the environment. here, we provide details of circumstances under which the pp can be applied to the topic of harm reduction in public health. the definition of pp that we use says that the pp reverses the onus of proof of effectiveness between an intervention and its comparator when ... | 2016 | 27458575 |
| detecting guillain-barré syndrome caused by zika virus using systems developed for polio surveillance. | | 2016 | 27708476 |
| utility of a dengue-derived monoclonal antibody to enhance zika infection in vitro. | zika virus (zikv) has emerged in dengue (denv) endemic areas, where these two related flaviviruses continue to co-circulate. denv is a complex of four serotypes and infections can progress to severe disease. it is thought that this is mediated by antibody dependent enhancement (ade) whereby antibodies from a primary denv infection are incapable of neutralizing heterologous denv infections with another serotype. ade has been demonstrated among other members of the flavivirus group. | 2016 | 27660733 |
| an open rna-seq data analysis pipeline tutorial with an example of reprocessing data from a recent zika virus study. | rna-seq analysis is becoming a standard method for global gene expression profiling. however, open and standard pipelines to perform rna-seq analysis by non-experts remain challenging due to the large size of the raw data files and the hardware requirements for running the alignment step. here we introduce a reproducible open source rna-seq pipeline delivered as an ipython notebook and a docker image. the pipeline uses state-of-the-art tools and can run on various platforms with minimal configur ... | 2016 | 27583132 |
| check the head: emergency ultrasound diagnosis of fetal anencephaly. | early pregnancy complaints in emergency medicine are common. emergency physicians (ep) increasingly employ ultrasound (us) in the evaluation of these complaints. as a result, it is likely that rare and important diagnoses will be encountered. we report a case of fetal anencephaly diagnosed by bedside emergency us in a patient presenting with first-trimester vaginal bleeding. | 2016 | 27429697 |
| integrating health research into disaster response: the new nih disaster research response program. | the need for high quality and timely disaster research has been a topic of great discussion over the past several years. recent high profile incidents have exposed gaps in knowledge about the health impacts of disasters or the benefits of specific interventions-such was the case with the 2010 gulf oil spill and recent events associated with lead-contaminated drinking water in flint, michigan, and the evolving health crisis related to zika virus disease. our inability to perform timely research t ... | 2016 | 27384574 |
| epidemiology of severe infections in latin american intensive care units. | | 0 | 27737431 |
| zika - global concern. | | 0 | 27610070 |
| the difficulties of 'living while girl'. | in this viewpoint, judith bruce answers questions from journal of virus eradication editor, sabine kinloch-de loës, on the importance of fulfilling the basic human rights of adolescent girls and their relationship with viral epidemics such as hiv. judith bruce is a graduate of harvard university and a senior associate and policy analyst at the population council, new york, usa, whose work is aimed at building the health, social and cognitive assets of girls in the poorest communities in the deve ... | 2016 | 27482459 |
| clean energy benefits the climate, the economy and our health. | jeffrey d sachs tells fiona fleck why investing in renewable energy is good for our health, but why poor countries need more time to make the switch. | 0 | 27429487 |
| clinical manifestations of zika virus infection, rio de janeiro, brazil, 2015. | | 2016 | 27070847 |
| zika virus-related news coverage and online behavior, united states, guatemala, and brazil. | | 2016 | 27100826 |
| development of medical countermeasures to middle east respiratory syndrome coronavirus. | preclinical development of and research on potential middle east respiratory syndrome coronavirus (mers-cov) medical countermeasures remain preliminary; advancements are needed before most countermeasures are ready to be tested in human clinical trials. research priorities include standardization of animal models and virus stocks for studying disease pathogenesis and efficacy of medical countermeasures; development of mers-cov diagnostics; improved access to nonhuman primates to support preclini ... | 2016 | 27191188 |
| zika - an emerging global threat. | | 2016 | 27822403 |
| mumps virus: modification of the identify-isolate-inform tool for frontline healthcare providers. | mumps is a highly contagious viral infection that became rare in most industrialized countries following the introduction of measles-mumps-rubella (mmr) vaccine in 1967. the disease, however, has been re-emerging with several outbreaks over the past decade. many clinicians have never seen a case of mumps. to assist frontline healthcare providers with detecting potential cases and initiating critical actions, investigators modified the "identify-isolate-inform" tool for mumps infection. the tool ... | 2016 | 27625709 |
| gut bacteria differentially affect egg production in the anautogenous mosquito aedes aegypti and facultatively autogenous mosquito aedes atropalpus (diptera: culicidae). | aedes aegypti and a. atropalpus are related mosquitoes that differ reproductively. aedes aegypti must blood-feed to produce eggs (anautogenous) while a. atropalpus always produces a first clutch of eggs without blood-feeding (facultatively autogenous). we recently characterized the gut microbiota of a. aegypti and a. atropalpus that were reared identically in the laboratory. here, we assessed the effects of specific members of the gut microbiota in a. aegypti and a. atropalpus on female fitness ... | 2016 | 27363842 |
| the brazilian dilemma: increased scientific production and high publication costs during a global health crisis and major economic downturn. | | 2016 | 27353760 |
| commentary: zika virus: the latest newcomer. | | 2016 | 27443350 |
| time to abandon the hygiene hypothesis: new perspectives on allergic disease, the human microbiome, infectious disease prevention and the role of targeted hygiene. | to review the burden of allergic and infectious diseases and the evidence for a link to microbial exposure, the human microbiome and immune system, and to assess whether we could develop lifestyles which reconnect us with exposures which could reduce the risk of allergic disease while also protecting against infectious disease. | 0 | 27354505 |
| mice are not men: adam30 findings emphasize a broader look towards murine alzheimer's disease models. | | 2016 | 27396345 |
| resistance status to the insecticides temephos, deltamethrin, and diflubenzuron in brazilian aedes aegypti populations. | insecticides are still largely applied in public health to control disease vectors. in brazil, organophosphates (op) and pyrethroids (py) are used against aedes aegypti for years. since 2009 insect growth regulators (igr) are also employed in the control of larvae. we quantified resistance to temephos (op), deltamethrin (py), and diflubenzuron (igr) of a. aegypti samples from 12 municipalities distributed throughout the country, collected between 2010 and 2012. high levels of resistance to neuro ... | 2016 | 27419140 |
| the current status of zika virus in southeast asia. | zika virus currently poses a global threat and is a major public health issue throughout latin america and the caribbean. however, zika virus infections in humans have also been observed in other regions, including southeast asia, where arboviral diseases are very common. in this study, we summarize the current status of zika virus in southeast asia. this review aims to provide an overview of the current situation and also to suggest ways of adequately managing the emergence of zika virus in sou ... | 2016 | 27336445 |
| the when and the where of zika epidemic potential in europe - an evidence base for public health preparedness. | | 2016 | 27333025 |
| instrument-free point-of-care molecular detection of zika virus. | the recent outbreak of zika virus (zikv) infection in the americas and its devastating impact on fetal development have prompted the world health organization (who) to declare the zikv pandemic as a public health emergency of international concern. rapid and reliable diagnostics for zikv are vital because zikv-infected individuals display no symptoms or nonspecific symptoms similar to other viral infections. because immunoassays lack adequate sensitivity and selectivity and are unable to identif ... | 2016 | 27306491 |
| defining clinical excellence in adult infectious disease practice. | clinical excellence should be recognized, particularly in the current climate that appropriately prioritizes relationship-centered care. in order to develop a recognition model, a definition of clinical excellence must be created and agreed upon. a paradigm recently suggested by c. christmas describes clinical excellence through the following domains: diagnostic acumen, professionalism and humanism, communication and interpersonal skills, skillful negotiation of the healthcare system, knowledge, ... | 2016 | 27419186 |
| potential risk of dengue and chikungunya outbreaks in northern italy based on a population model of aedes albopictus (diptera: culicidae). | the rapid invasion and spread of aedes albopictus (skuse, 1894) within new continents and climatic ranges has created favorable conditions for the emergence of tropical arboviral diseases in the invaded areas. we used mosquito abundance data from 2014 collected across ten sites in northern italy to calibrate a population model for aedes albopictus and estimate the potential of imported human cases of chikungunya or dengue to generate the condition for their autochthonous transmission in the abse ... | 2016 | 27304211 |
| larvicidal efficacies of plants from midwestern brazil: melianodiol from guarea kunthiana as a potential biopesticide against aedes aegypti. | a total of 36 ethanol extracts from different anatomical parts of 27 plant species (18 families), native to the pantanal and cerrado biomes in midwest brazil, was assessed for their effect against aedes aegypti larvae, the vector of dengue, hemorrhagic dengue, zika and chikungunya fevers. only the extract obtained from seeds of guarea kunthiana (meliaceae) proved active (lc50 = 169.93 μg/ml). a bioassay-guided investigation of this extract led to the isolation and identification of melianodiol, ... | 0 | 27333366 |
| reproductive health is pleased to announce a mandatory open data policy in the journal. | | 2016 | 27296276 |
| flirt-ing with zika: a web application to predict the movement of infected travelers validated against the current zika virus epidemic. | beginning in 2015, zika virus rapidly spread throughout the americas and has been linked to neurological and autoimmune diseases in adults and babies. developing accurate tools to anticipate zika spread is one of the first steps to mitigate further spread of the disease. when combined, air traffic data and network simulations can be used to create tools to predict where infectious disease may spread to and aid in the prevention of infectious diseases. specific goals were to: 1) predict where tra ... | 2016 | 27366587 |
| the ebola virus disease outbreak in west africa: a wake-up call to revitalize implementation of the international health regulations. | the 2014/15 ebola virus disease (evd) outbreak in west africa has highlighted the inherent weaknesses associated with the implementation of the international health regulations (ihr). in this perspective article, the lessons learnt from the outbreak are used to review the challenges impeding effective implementation of the ihr and to propose policy and strategic options for enhancing its application. while some progress has been achieved in implementing the ihr in several countries, numerous cha ... | 2016 | 27376056 |
| radiological characterization of cerebral phenotype in newborn microcephaly cases from 2015 outbreak in brazil. | brazil is facing, since october of 2015, an outbreak of microcephalic fetuses. this outbreak is correlated with the beginning of circulation of zika virus (zikv) in the country. although it is clear that the size of the head is diminished in these fetuses, the brain phenotype associated with these malformations is unknown. | 2016 | 27617166 |
| wolbachia blocks currently circulating zika virus isolates in brazilian aedes aegypti mosquitoes. | the recent association of zika virus with cases of microcephaly has sparked a global health crisis and highlighted the need for mechanisms to combat the zika vector, aedes aegypti mosquitoes. wolbachia pipientis, a bacterial endosymbiont of insect, has recently garnered attention as a mechanism for arbovirus control. here we report that aedes aegypti harboring wolbachia are highly resistant to infection with two currently circulating zika virus isolates from the recent brazilian epidemic. wolbac ... | 2016 | 27156023 |
| human saliva collection devices for proteomics: an update. | there has been a rapid growth in the interest and adaptation of saliva as a diagnostic specimen over the last decade, and in the last few years in particular, there have been major developments involving the application of saliva as a clinically relevant specimen. saliva provides a "window" into the oral and systemic health of an individual, and like other bodily fluids, saliva can be analyzed and studied to diagnose diseases. with the advent of new, more sensitive technologies to detect smaller ... | 2016 | 27275816 |
| understanding zika virus pathogenesis: an interview with catherine spong. | a recent outbreak of zika virus has been linked to fetal abnormalities in pregnant women who have been infected. the scientific community is working toward understanding zika virus pathogenesis to better manage affected women and children. in an interview with dr. catherine spong, we discuss the aims and challenges of a forthcoming longitudinal study of a cohort of pregnant women in areas of current active zika virus transmission. | 2016 | 27268016 |
| first international workshop on zika virus held by oswaldo cruz foundation fiocruz in northeast brazil march 2016 - a meeting report. | | 2016 | 27258065 |
| utilizing nontraditional data sources for near real-time estimation of transmission dynamics during the 2015-2016 colombian zika virus disease outbreak. | approximately 40 countries in central and south america have experienced local vector-born transmission of zika virus, resulting in nearly 300,000 total reported cases of zika virus disease to date. of the cases that have sought care thus far in the region, more than 70,000 have been reported out of colombia. | 2016 | 27251981 |
| zika is not a reason for missing the olympic games in rio de janeiro: response to the open letter of dr attaran and colleagues to dr margaret chan, director - general, who, on the zika threat to the olympic and paralympic games. | attaran and colleagues in an open letter to who expressed their concern about the upcoming olympic and paralympic games in rio de janeiro and the threat posed by the zika epidemic (attaran 2016). we agree that zika virus is of great public health concern and much remains to be known about this disease. care should be taken to reduce the risk of infection, especially to pregnant women. however, we argue that this is not sufficient reason for changing the original plans for the games, in particula ... | 0 | 27304097 |
| defining the syndrome associated with congenital zika virus infection. | | 0 | 27274588 |
| the development of small animal models for zika virus vaccine efficacy testing and pathological assessment. | | 2016 | 27139439 |
| maternal inflammation disrupts fetal neurodevelopment via increased placental output of serotonin to the fetal brain. | maternal inflammation during pregnancy affects placental function and is associated with increased risk of neurodevelopmental disorders in the offspring. the molecular mechanisms linking placental dysfunction to abnormal fetal neurodevelopment remain unclear. during typical development, serotonin (5-ht) synthesized in the placenta from maternal l-tryptophan (trp) reaches the fetal brain. there, 5-ht modulates critical neurodevelopmental processes. we investigated the effects of maternal inflamma ... | 0 | 27251625 |
| zika virus in a traveler returning to china from caracas, venezuela, february 2016. | | 2016 | 27070735 |
| travel volume to the united states from countries and u.s. territories with local zika virus transmission. | air, land, and sea transportation can facilitate rapid spread of infectious diseases. in may 2015 the pan american health organization (paho) issued an alert regarding the first confirmed zika virus infection in brazil. as of march 8, 2016, the u.s. centers for disease control and prevention (cdc) had issued travel notices for 33 countries and 3 u.s. territories with local zika virus transmission. | 2016 | 27990321 |
| zika: what we do and do not know based on the experiences of brazil. | zika virus, which was first discovered in 1947, has become a global threat to human health as it is rapidly spreading through latin america, the caribbean, the us and asia, after causing a large outbreak in the northeast region of brazil in 2015. there is ample evidence to support that zika virus is associated with neurological complications such as microcephaly. the review aims to provide an overview on the complex issues involved in the emergence of zika virus's neurological disorders and to d ... | 2016 | 27283140 |
| using phenomenological models to characterize transmissibility and forecast patterns and final burden of zika epidemics. | the world health organization declared the ongoing zika virus (zikv) epidemic in the americas a public health emergency of international concern on february 1, 2016. zikv disease in humans is characterized by a "dengue-like" syndrome including febrile illness and rash. however, zikv infection in early pregnancy has been associated with severe birth defects, including microcephaly and other developmental issues. mechanistic models of disease transmission can be used to forecast trajectories and l ... | 2016 | 27366586 |
| some vexations that challenge viral immunology. | the field of viral immunology seeks to understand mechanisms of virus-host interaction with a view of applying this knowledge to the design of effective vaccines and immunomodulators that control viral infections. this brief review discusses several areas of the field that hold substantial promise for translation, but where further work is critically required to find solutions. we emphasize that our fundamental understanding of virus-host relationships is moving in leaps and bounds, but we lag b ... | 2016 | 27303640 |
| zika in the united states of america and a fateful 1969 decision. | the united states gulf coast's current risk to zika transmitted by aedes aegypti mosquitoes can be traced back to some important federal health policy decisions made during the 1960s. | 2016 | 27227971 |
| sporadic cases of adult measles: a research article. | measles caused by a paramyxovirus, characterized by fever, malaise, cough, coryza conjunctivitis, a maculopapular rash is known to result in pneumonia, encephalitis and death. fatal cases of measles in sri lanka are rare after implementation of the national immunization programme in 1984. thereafter 0.1% case fatality rate was observed during october 1999-june 2000 which is a very low figure compared to other regional countries. immunization guidelines were further revised in 2001, 2011 and in 2 ... | 2017 | 28069071 |
| establishment of an accurate and fast detection method using molecular beacons in loop-mediated isothermal amplification assay. | this study established a constant-temperature fluorescence quantitative detection method, combining loop-mediated isothermal amplification (lamp) with molecular beacons. the advantages of lamp are its convenience and efficiency, as it does not require a thermocycler and results are easily visualized by the naked eye. however, a major disadvantage of current lamp techniques is the use of indirect evaluation methods (e.g., electrophoresis, sybr green i dye, precipitation, hydroxynaphthol blue dye, ... | 2017 | 28059137 |
| the larvicide pyriproxyfen blamed during the zika virus outbreak does not cause microcephaly in zebrafish embryos. | although the zika virus (zikv) has now been strongly correlated with emerging cases of microcephaly in the americas, suspicions have been raised regarding the use of pyriproxyfen, a larvicide that prevents mosquito development, in drinking water. the effects of this compound on neurodevelopment have not yet been addressed specifically in vertebrates. as a result, we aimed at addressing the effects, if any, of pyriproxyfen on neurodevelopment in the zebrafish embryo as a vertebrate model. using z ... | 2017 | 28051181 |
| pediatric neurology briefs: year in review. | pediatric neurology briefs (pnb) has been published monthly since 1987 as a continuing education service designed to expedite and facilitate review of current medical literature concerning pediatric neurology. | 0 | 28070150 |
| public health round-up. | | 0 | 28053357 |
| acute flaccid paralysis incidence and zika virus surveillance, pacific islands. | the emergence of zika virus has challenged outbreak surveillance systems in many at-risk, low-resource countries. as the virus has been linked with guillain-barré syndrome, routine data on the incidence of acute flaccid paralysis (afp) may provide a useful early warning system for the emergence of zika virus. | 0 | 28053366 |
| persistent zika virus detection in semen in a traveler returning to the united kingdom from brazil, 2016. | zika virus is normally transmitted by mosquitos, but cases of sexual transmission have been reported. we describe a patient with symptomatic zika virus infection in whom the virus was detected in semen for 92 days. our findings support recommendations for 6 months of barrier contraceptive use after symptomatic zika virus infection. | 2017 | 27748650 |
| cost-effectiveness of increasing access to contraception during the zika virus outbreak, puerto rico, 2016. | we modeled the potential cost-effectiveness of increasing access to contraception in puerto rico during a zika virus outbreak. the intervention is projected to cost an additional $33.5 million in family planning services and is likely to be cost-saving for the healthcare system overall. it could reduce zika virus-related costs by $65.2 million ($2.8 million from less zika virus testing and monitoring and $62.3 million from avoided costs of zika virus-associated microcephaly [zam]). the estimates ... | 2017 | 27805547 |
| zika virus knowledge among pregnant women who were in areas with active transmission. | we surveyed women in new york, new york, usa, who were in areas with active zika virus transmission while pregnant. of 99 women who were us residents, 30 were unaware of the government travel advisory to areas with active zika virus transmission while pregnant, and 37 were unaware of their pregnancies during travel. | 2017 | 27855041 |
| reconstruction of zika virus introduction in brazil. | we estimated the speed of zika virus introduction in brazil by using confirmed cases at the municipal level. our models indicate a southward pattern of introduction starting from the northeastern coast and a pattern of movement toward the western border with an average speed of spread of 42 km/day or 15,367 km/year. | 2017 | 27618573 |
| guillain-barré syndrome and healthcare needs during zika virus transmission, puerto rico, 2016. | to assist with public health preparedness activities, we estimated the number of expected cases of zika virus in puerto rico and associated healthcare needs. estimated annual incidence is 3.2-5.1 times the baseline, and long-term care needs are predicted to be 3-5 times greater than in years with no zika virus. | 2017 | 27779466 |
| military-civilian cooperative emergency response to infectious disease prevention and control in china. | in recent years, the incidence of severe infectious diseases has increased, and the number of emerging infectious diseases continues to increase. the chinese government and military forces have paid a great deal of attention to infectious disease prevention and control, and using military-civilian cooperation, they have successfully prevented numerous severe epidemic situations, such as severe acute respiratory syndrome (sars), influenza a (h1n1), avian influenza h5n1 and h7n9, and ebola hemorrh ... | 2016 | 28050261 |
| plasmodium vivax landscape in brazil: scenario and challenges. | brazil is the largest country of latin america, with a considerable portion of its territoritory within the malaria-endemic amazon region in the north. furthermore, a considerable portion of its territory is located within the amazon region in the north. as a result, brazil has reported half of the total malaria cases in the americas in the last four decades. recent progress in malaria control has been accompanied by an increasing proportion of plasmodium vivax, underscoring a need for a better ... | 2016 | 27708190 |
| zika travel policies may reduce women's leadership in global health. | | 2016 | 28031307 |
| social mobilization and community engagement central to the ebola response in west africa: lessons for future public health emergencies. | following the world health organization (who) declaration of a public health emergency of international concern regarding the ebola outbreak in west africa in july 2014, unicef was asked to co-lead, in coordination with who and the ministries of health of affected countries, the communication and social mobilization component-which unicef refers to as communication for development (c4d)-of the ebola response. for the first time in an emergency setting, c4d was formally incorporated into each cou ... | 2016 | 28031301 |
| zika virus infection induces mitosis abnormalities and apoptotic cell death of human neural progenitor cells. | zika virus (zikv) infection has been associated with severe complications both in the developing and adult nervous system. to investigate the deleterious effects of zikv infection, we used human neural progenitor cells (npc), derived from induced pluripotent stem cells (ipsc). we found that npc are highly susceptible to zikv and the infection results in cell death. zikv infection led to a marked reduction in cell proliferation, ultrastructural alterations and induction of autophagy. induction of ... | 2016 | 28008958 |
| atg16l1 governs placental infection risk and preterm birth in mice and women. | the placenta is a barrier against maternal-fetal transmission of pathogens. placental infections can cause several adverse pregnancy outcomes, including preterm birth (ptb). yet, we have limited knowledge regarding the mechanisms the placenta uses to control infections. here, we show that autophagy, a cellular recycling pathway important for host defense against pathogens, and the autophagy gene atg16l1 play a key role in placental defense and are negatively associated with ptb in pregnant women ... | 2016 | 28018968 |
| simple reverse genetics systems for asian and african zika viruses. | zika virus (zikv), a typical example of a re-emerging pathogen, recently caused large outbreaks in pacific islands and the americas, associated with congenital diseases and neurological complications. deciphering the natural history, ecology and pathophysiology of this mosquito-borne pathogen requires effective reverse genetics tools. in the current study, using the bacterium-free 'infectious subgenomic amplicons' (isa) method, we generated and made available to the scientific community via the ... | 2016 | 27991555 |
| modernising epidemic science: enabling patient-centred research during epidemics. | emerging and epidemic infectious disease outbreaks are a significant public health problem and global health security threat. as an outbreak begins, epidemiological investigations and traditional public health responses are generally mounted very quickly. however, patient-centred research is usually not prioritised when planning and enacting the response. instead, the clinical research response occurs subsequent to and separate from the public health response, and is inadequate for evidence-base ... | 2016 | 27989237 |
| contraceptive sales in the setting of the zika virus epidemic. | has there been any influence of the zika virus (zikv) outbreak on the sales of contraceptive methods in brazil? | 2016 | 27932442 |
| dishing out mini-brains: current progress and future prospects in brain organoid research. | the ability to model human brain development in vitro represents an important step in our study of developmental processes and neurological disorders. protocols that utilize human embryonic and induced pluripotent stem cells can now generate organoids which faithfully recapitulate, on a cell-biological and gene expression level, the early period of human embryonic and fetal brain development. in combination with novel gene editing tools, such as crispr, these methods represent an unprecedented m ... | 2016 | 27402594 |
| perspectives on the role of mobility, behavior, and time scales in the spread of diseases. | the dynamics, control, and evolution of communicable and vector-borne diseases are intimately connected to the joint dynamics of epidemiological, behavioral, and mobility processes that operate across multiple spatial, temporal, and organizational scales. the identification of a theoretical explanatory framework that accounts for the pattern regularity exhibited by a large number of host-parasite systems, including those sustained by host-vector epidemiological dynamics, is but one of the challe ... | 2016 | 27965394 |
| estimation of zika virus prevalence by appearance of microcephaly. | there currently is a severe zika virus (zikv) epidemic in brazil and other south american countries. due to international travel, this poses severe public health risk of zikv importation to other countries. we estimate the prevalence of zikv in an import region by the time a microcephaly case is detected, since microcephaly is presently the most significant indication of zikv presence. | 2016 | 27955630 |
| rapid, affordable and portable medium-throughput molecular device for zika virus. | zika virus (zikv) has gained global attention as an etiologic agent of fetal microcephaly and guillain-barré syndrome. existing immuno-based rapid tests often fail to distinguish between zika and related flaviviruses that are common in affected regions of central and south americas and the caribbean. the us cdc and qualified state health department laboratories can perform the reverse transcription polymerase chain reaction (rt-pcr) zikv test using highly sophisticated instruments with long turn ... | 2016 | 27934884 |
| a historic report of zika in mozambique: implications for assessing current risk. | | 2016 | 27930650 |
| public health interventions for aedes control in the time of zikavirus- a meta-review on effectiveness of vector control strategies. | there is renewed interest in effective measures to control zika and dengue vectors. a synthesis of published literature with a focus on the quality of evidence is warranted to determine the effectiveness of vector control strategies. | 2016 | 27926934 |
| the self-regulation model of illness: comparison between zika and dengue and its application to predict mosquito prevention behaviours in malaysia, a dengue-endemic country. | perceptions about illnesses may influence self-care and preventive health behaviours. illness perceptions of the zika virus (zikv) infection were investigated under the framework of the self-regulation model of illness. illness perception differences between zikv and dengue fever were also examined. lastly, associations between illness perceptions of zikv with mosquito prevention practices were studied. samples were drawn from landline telephone numbers using computer-assisted telephone intervie ... | 2016 | 27929451 |
| deep sequencing of the 16s ribosomal rna of the neonatal oral microbiome: a comparison of breast-fed and formula-fed infants. | in utero and upon delivery, neonates are exposed to a wide array of microorganisms from various sources, including maternal bacteria. prior studies have proposed that the mode of feeding shapes the gut microbiota and, subsequently the child's health. however, the effect of the mode of feeding and its influence on the development of the neonatal oral microbiota in early infancy has not yet been reported. the aim of this study was to compare the oral microbiota of healthy infants that were exclusi ... | 2016 | 27922070 |
| effective risk governance requires risk communication experts. | | 2016 | 27919122 |
| from global health security to global health solidarity, security and sustainability. | | 0 | 27994276 |
| comparative genomics of beauveria bassiana: uncovering signatures of virulence against mosquitoes. | entomopathogenic fungi such as beauveria bassiana are promising biological agents for control of malaria mosquitoes. indeed, infection with b. bassiana reduces the lifespan of mosquitoes in the laboratory and in the field. natural isolates of b. bassiana show up to 10-fold differences in virulence between the most and the least virulent isolate. in this study, we sequenced the genomes of five isolates representing the extremes of low/high virulence and three rna libraries, and applied a genome c ... | 2016 | 27905873 |
| tracking insecticide resistance in mosquito vectors of arboviruses: the worldwide insecticide resistance network (win). | | 2016 | 27906961 |
| human igg antibody response to aedes nterm-34kda salivary peptide, an epidemiological tool to assess vector control in chikungunya and dengue transmission area. | arboviral diseases are an important public health concerns. vector control remains the sole strategy to fight against these diseases. because of the important limits of methods currently used to assess human exposure to aedes mosquito bites, much effort is being devoted to develop new indicators. recent studies have reported that human antibody (ab) responses to aedes aegypti nterm-34kda salivary peptide represent a promising biomarker tool to evaluate the human-aedes contact. the present study ... | 2016 | 27906987 |
| peering below the diffraction limit: robust and specific sorting of viruses with flow cytometry. | viruses are incredibly diverse organisms and impact all forms of life on earth; however, individual virions are challenging to study due to their small size and mass, precluding almost all direct imaging or molecular analysis. moreover, like microbes, the overwhelming majority of viruses cannot be cultured, impeding isolation, replication, and study of interesting new species. here, we introduce pcr-activated virus sorting, a method to isolate specific viruses from a heterogeneous population. sp ... | 2016 | 27906039 |
| carrion's disease: an eradicable illness? | carrion's disease is a neglected tropical disease caused by bartonella bacilliformis, a vector-borne pathogen restricted to the andean valleys of peru, ecuador and colombia. carrion's disease is a biphasic illness; in the acute phase the case-fatality rate can be as high as 88 %, related to high parasitemia, arriving to almost all erythrocytes, and secondary bacterial infections close related with the development of transient immunosuppression in the earlier illness phases. in addition, there ar ... | 2016 | 27903286 |
| zika virus cell tropism in the developing human brain and inhibition by azithromycin. | the rapid spread of zika virus (zikv) and its association with abnormal brain development constitute a global health emergency. congenital zikv infection produces a range of mild to severe pathologies, including microcephaly. to understand the pathophysiology of zikv infection, we used models of the developing brain that faithfully recapitulate the tissue architecture in early to midgestation. we identify the brain cell populations that are most susceptible to zikv infection in primary human tis ... | 2016 | 27911847 |