| failure of influenza vaccination in the aged. | a cohort of 127 nursing home residents aged 60-98 years were vaccinated during the winter of 1985-86 with the a-chile 1/83 (c), a-philippines 2/82 (p), and b-ussr (b) commercial influenza vaccines. before vaccination 40%, 23%, and 69% were susceptible to influenza ac, ap, and b, respectively [hemagglutinin inhibition (h.i.) titer less than 1:40]. one month following initial vaccination, 32 patients [25%] remained unprotected against two or all three vaccine strains. these patients were revaccina ... | 1988 | 3411310 |
| [effect of the matrix protein of the influenza virus on oxidative phosphorylation in preparations of isolated liver mitochondria from white mice]. | the effect of matrix proteins (m proteins) of influenza a/mrc-11 and b/lee viruses on oxidative phosphorylation in preparations of isolated mitochondria of white mice liver was studied. m proteins were shown to cause disorders in the system of oxidative phosphorylation leading to reduction of the coefficient of respiratory control and amplification coefficient recorded by the polarographic method. it was also shown that an anti-influenza compound 2-(1'-aminoethyl)-bicyclo(2.2.1)heptane hydrochlo ... | 1988 | 3414064 |
| reye's syndrome-like illness in a patient receiving amiodarone. | a 16-yr-old boy who was receiving amiodarone for ventricular arrhythmias developed a reye's syndrome-like illness several days after an upper respiratory infection. liver biopsy revealed microvesicular fat and spotty hepatocellular necrosis, typical of reye's syndrome. recovery was complete. this case report suggests that medications other than aspirin may predispose to reye's syndrome, and that children receiving amiodarone should receive prophylaxis against influenza b and chicken pox. | 1988 | 3414648 |
| comparative activities of several nucleoside analogs against influenza a, b, and c viruses in vitro. | a set of 20 nucleoside analogs were examined for their inhibitory effects on the cytopathogenicity and growth of influenza virus type a, b, and c strains in madin-darby canine kidney (mdck) cells. among the compounds evaluated, pyrazofurin, 3-deazaguanine, ribavirin, carbodine, and cyclopentenyl cytosine inhibited viral cytopathogenicity at concentrations that were lower than those found cytotoxic for the mdck cells. no differences were observed in the 50% effective doses (based on inhibition of ... | 1988 | 3415210 |
| [activity of influenza virus in the metropolitan region of panama city, 1976-1986]. | | 1987 | 3423321 |
| novel pyrazolo[3,4-d]pyrimidine nucleoside analog with broad-spectrum antiviral activity. | a novel nucleoside analog, 4(5h)-oxo-1-beta-d- ribofuranosylpyrazolo[3,4-d]pyrimidine-3-thiocarboxamide (n10169), was evaluated in cell culture and in animals for antiviral activity against dna and rna viruses. the compound was highly active against strains of adeno-, vaccinia, influenza b, paramyxo-, picorna-, and reoviruses, with 50% inhibition of virus-induced cytopathology at 1 to 10 microm. lesser or no antiviral effects were observed against herpes simplex, cytomegalo-, corona-, influenza ... | 1987 | 3435102 |
| epidemiological research on the phenomenon of the influenza herald wave. | | 1987 | 3437042 |
| irregular appearance of antiviral activity of complement in the hemagglutination-inhibition test. | | 1987 | 3439033 |
| serological testing of human blood samples for infectious diseases in the abeokuta and the minna hospitals/nigeria. | in serological investigations undertaken in two hospitals in nigeria a total of 188 blood samples were examined and the following positive reactions for various diseases found: malaria 100%, leishmaniasis 9.5%, biharziasis 2.1%, yersinia 16.4%, legionella pn. 9%, gonorrhea 6%, syphilis 6.9%, measles 65.4%, rubella 84%, cytomegalic 78.2%, herpes simplex 67%, varicella 30.8%, resp. sync. virus 34.6%, influenza a 57.4%, influenza b 73.9%, para-influenza 1, 2, 3, 20.7%, 16.5%, 52.6%, adenovirus 25%, ... | 1987 | 3443750 |
| influenza a and b antibody status in tanzania. | sera from 200 babies and young children and from 205 mother-newborn pairs were tested for haemagglutination inhibiting antibody against three a-h1n1, one a-h2n2, four a-h3n2, and two influenza b viruses. the results indicated that a higher concentration of antibody against all influenza a and b viruses tested was found more frequently in maternal sera than in neonatal sera. high prevalences of antibody and high geometric mean titres against the a-h2n2-1957 and a-h3n2-1968 viruses from the eras 1 ... | 1987 | 3445328 |
| influenza vaccination in a boarding school population. | | 1987 | 3451775 |
| intraepidemic heterogeneity of influenza b viruses isolated in 1986. antigenic and biological characteristics. | | 1987 | 3455655 |
| viral infection in patients with multiple sclerosis and hla-dr matched controls. | retrospective comparisons of the prevalence and age, where appropriate, of some childhood infectious illnesses and vaccinations, together with serological evidence for exposure to 16 viruses, many of which have previously been implicated in the aetiology of multiple sclerosis (ms) were made in 177 patients with acute optic neuritis, other recent isolated demyelinating episodes or established ms and 164 controls. the expected high frequency of hla-dr2 in patients with demyelinating disease was ma ... | 1986 | 3456817 |
| segment-specific and common nucleotide sequences in the noncoding regions of influenza b virus genome rnas. | the nucleotide sequences of the 3' noncoding regions of all eight segments of influenza b virus rna and the sequences of the 5' noncoding regions of segments 4-8 were determined in virus strains isolated over a period of 40 years. nearly complete conservation of the noncoding sequences was found. nine nucleotides at the 3' termini and 11 nucleotides at the 5' termini were common to all segments examined. in the region immediately adjacent to the common 3' terminal region, the nucleotides were sp ... | 1987 | 3472232 |
| segment-specific inverted repeats found adjacent to conserved terminal sequences in wound tumor virus genome and defective interfering rnas. | defective interfering (di) rnas are often associated with transmission-defective isolates of wound tumor virus (wtv), a plant virus member of the reoviridae. we report here the cloning and characterization of wtv genome segment s5 [2613 base pairs (bp)] and three related di rnas (587-776 bp). each di rna was generated by a simple internal deletion event that resulted in no sequence rearrangement at the deletion boundaries. remarkably, although several di rnas have been in continuous passage for ... | 1987 | 3479793 |
| [immunity of the populations of the ussr and east germany to reference strains of influenza viruses and the characteristics of a new antigenic variant of the virus]. | in 1985, a new epidemic variant of influenza virus, a/berlin/6/85 (h3n2) was isolated which differed antigenically from the reference a/philippines/2/82 virus. the results of the study of population immunity in adults and children of the ussr and gdr to these virus variants confirm the data on the continuing drift of virus a (h3n2). | 1987 | 3500544 |
| idiotypic analysis of the influenza virus-specific human b cell repertoire. | | 1987 | 3501829 |
| genetics of cold-adapted b/ann arbor/1/66 influenza virus reassortants: the acidic polymerase (pa) protein gene confers temperature sensitivity and attenuated virulence. | the cold-adapted b/ann arbor/1/66 influenza virus (ca b/aa/1/66) expresses temperature-sensitive (ts), cold-adapted (ca) and attenuation phenotypes. reassortants which inherit one or more genes from ca b/aa/1/66 and all other genes from a virulent, wild-type influenza virus, b/houston/1732/76, were produced and evaluated in order to identify the gene(s) responsible for the ts, ca and attenuation phenotypes. only reassortants which inherited the pa gene from ca b/aa/1/66 expressed the ts phenotyp ... | 1987 | 3504545 |
| [diagnostic significance of igm class-specific antibodies in influenza]. | | 1986 | 3515763 |
| [basic results of a committee trial of the new vaccine grippovac se-azh]. | in the trial of the trivalent subunit influenza vaccine grippovac ce-ak observations on children aged 3-6 years were made. the preparation showed insignificant reactogenicity and moderate antigenic potency. the trial established that at the period of the epidemic rise of influenza b morbidity the vaccine showed, according to the data of the clinical diagnosis of influenza, insignificant effectiveness, its index of effectiveness (ie) being 1.08; according to the data of the serological diagnosis ... | 1986 | 3515812 |
| characterization and evaluation of monoclonal antibodies developed for typing influenza a and influenza b viruses. | monoclonal antibodies that are broadly reactive with influenza a or influenza b viruses were produced as stable reagents for typing influenza viruses. monoclonal antibodies to influenza a were specific for either matrix protein or nucleoprotein. the antibodies to influenza b were specific for nucleoprotein or hemagglutinin protein. in an enzyme immunoassay procedure, influenza a antibodies detected h1n1, h2n2, and h3n2 influenza a virus strains collected between 1934 and 1984. each of the influe ... | 1986 | 3517049 |
| effectiveness of rimantadine prophylaxis of children within families. | with recent studies suggesting that children are the main introducers of influenza infections into families, we conducted a placebo-controlled, double-blind, randomized trial to study the prophylactic effectiveness of rimantadine hydrochloride in children on the transmission of influenza a infections within families. one hundred forty-five volunteers from 35 families completed this study during a naturally occurring outbreak of influenza a (h1n1) infection. influenza infections, defined as a pos ... | 1986 | 3521258 |
| [live influenza vaccine in the ussr: its development, study and practical use]. | | 1986 | 3529762 |
| rapid detection of influenza virus by shell vial assay with monoclonal antibodies. | of 45 influenza virus strains (43 type a and 2 type b) detected in conventional tube cell cultures (average time, 4 days), 25 (56%) were detected by immunofluorescence in the shell vial assay 24 h postinoculation. the specific fluorescence produced should allow this procedure to be readily adapted by laboratories with various degrees of experience with immunofluorescence methodology. | 1986 | 3533980 |
| time-resolved fluoroimmunoassay with monoclonal antibodies for rapid diagnosis of influenza infections. | monoclonal antibodies that are broadly reactive with either influenza a or influenza b viruses were used to develop a 2- to 3-h antigen capture time-resolved fluoroimmunoassay (tr fia) for detecting influenza viral antigens in both original nasopharyngeal aspirate specimens and in tissue cultures inoculated with nose or throat swab specimens. the lower limit of sensitivity of the assay was about 10 pg of protein as determined with purified influenza a nucleoprotein expressed by recombinant dna. ... | 1986 | 3537001 |
| [comparative evaluation of the sensitivity of immunofluorescence methods, immunoenzyme analysis and the lectin test for the rapid diagnosis of influenza]. | comparative study of the sensitivities of immunofluorescent microscopy (ifm), enzyme immunoassay, (eia), and lectin test (lt) in the detection of influenza virus antigen in nasopharyngeal washings from patients with influenza, acute respiratory diseases, pneumonia, and laryngitis has been carried out. eia modification (used in this study) based on the detection of a complex of viral core proteins (m + rnp) has been shown to be no less sensitive than ifm and suitable for use in the rapid diagnosi ... | 1986 | 3538729 |
| subtype-specific identification of influenza virus in cell cultures with fitc labelled egg yolk antibodies. | we report on results obtained with a direct immunofluorescence test for subtype-specific identification of influenza virus in detached cells of mdck cultures after inoculation of 281 clinical specimens from patients with influenza-like disease. influenza virus antibodies were produced in eggs from immunized hens and labelled with fitc. in 157 cases cpe was found in mdck cells. a total of 57 cases of influenza a (h3n2), 86 cases of influenza a (h1n1), and 14 cases of influenza b were identified. ... | 1987 | 3547056 |
| [isolation and study of the properties of igg from antisera to influenza virus proteins]. | igg to internal (np, m) and external (ha, na) proteins of influenza virus were isolated from immune rabbit sera using caprylic acid. the igg retained their specificity and activity, worked in hi, lectin test, and enzyme-immunoassay. igg migrated towards cathode in electrophoresis on acetate cellulose. electrophoresis in polyacrylamide gel revealed a heavy chain (55,000) and a light chain (25,000) in igg molecule. different methods revealed changes in igg structure after lyophilization. the possi ... | 1987 | 3554755 |
| [humoral immunity indices of chronic alcoholism patients]. | sera obtained from 642 patients with chronic alcoholism and 400 sera from healthy donors, collected in different regions of the ussr (moscow, the kirghiz ssr, transcarpathian province, the northern caucasus), were studied. out of all patients with chronic alcoholism whose blood sera were examined, persons aged 20-30 years constituted 22%, 31-40 years, 41.8%, 41-50 years, 27.5%, above 50 years, 8.7%. the results of the study of the immune structure of these patients with respect to the causative ... | 1987 | 3564781 |
| acute respiratory disease associated with influenza epidemics in houston, 1981-1983. | virological surveillance at "sentinel" clinics in houston has demonstrated that the annual peak in the number of visits for acute respiratory disease (ard) always coincides with the peak of influenza virus activity. a survey of visits to a health maintenance organization between 1981 and 1983 allowed us to calculate the age-specific rates of visits for ard during two moderately severe influenza epidemics (1981-1982 and 1982-1983). during the most intense period of influenza virus activity the ra ... | 1987 | 3572033 |
| inactivation of influenza b virus by normal guinea-pig serum. | normal guinea-pig serum (gps) lacking detectable antiviral antibody efficiently neutralized the infectivity of influenza b virus grown in chick embryos or mdck cells. the inhibitor was heat-labile and sensitive to trypsin digestion. this beta-like inhibitor required ca2+ and the complement components c1 and c4 for its activity. in contrast, gps did not inactivate influenza a virus. influenza b virus from which the neuraminidase activity of the spikes on the viral envelope had been eliminated by ... | 1987 | 3572357 |
| trivalent influenza vaccine in patients on haemodialysis: impaired seroresponse with differences for a-h3n2 and a-h1n1 vaccine components. | one hundred and one patients on haemodialysis, 21 patients on peritoneal dialysis and 30 healthy controls received a trivalent split vaccine containing 15 micrograms haemagglutinin of a recent influenza a-h3n2, influenza a-h1n1 and influenza b strain, respectively. antibody production after four weeks was determined by the haemagglutination-inhibition test and expressed as response rate, protection rate and overall mean fold increase. the patients on haemodialysis revealed a diminished serorespo ... | 1987 | 3577356 |
| relative antigenicity in mice of h1n1, h3n2 and b strains present in inactivated influenza virus vaccines. | the results of a study on serum hai and neutralizing antibodies induced in mice by whole influenza virus vaccines containing a/brazil/11/78 (h1n1), a/bangkok/1/79 (h3n2) and b/singapore/222/79 viruses are reported. according to the gmt of hai, the antigenic potency of the three vaccine strains appear to be different. the a/brazil/11/78 antigen induced the lowest hai antibody responses and the a/bangkok/1/79 antigen the greatest. this behaviour, with a few exceptions, was noted regardless of the ... | 1987 | 3582601 |
| studies on human beings inoculated with influenza vaccine and bearing hi antibody against actual prevailing strains. | | 1987 | 3584410 |
| outbreak of respiratory illness on board a ship cruising to ports in southern europe and northern africa. | a large outbreak of influenza-like and diarrhoeal illness took place over a period of 21 days in april 1984 on board a ship cruising to ports in southern europe and northern africa. a cohort study of the 418 passengers was made by postal questionnaire and personal interview. of the 391 passengers who were interviewed or who returned a questionnaire, 335 (86%) were affected. of the ill passengers, 295 (88%) had an influenza-like illness. these included 20 with signs of lower respiratory tract inf ... | 1987 | 3585036 |
| [treatment of patients with influenza and acute respiratory viral infections using mefenamic acid]. | | 1987 | 3590689 |
| [results of a study of new preparations of inactivated whole-virion influenza vaccines for the protection of children in the ussr]. | the safety, reactogenic properties and antigenic potency of inactivated whole-virion influenza vaccines produced in the ussr were studied on 1,117 schoolchildren in limited coded clinico-immunological observations. inactivated chromatographic influenza vaccine obtained from strain a/texas/1/77 (h3n2) and a variant of this vaccine, developed specially for children and obtained from strains a/texas/1/77 and b/leningrad/76, were used for immunization. both preparations were introduced intradermally ... | 1987 | 3591124 |
| [involvement of the cardiovascular system in patients with influenza caused by type b virus]. | | 1987 | 3599832 |
| hepatic lipid abnormalities in a chemical/viral mouse model for reye's syndrome. | we have examined hepatic lipid profiles in a mouse model for reye's syndrome (rs) in which young animals are exposed to nontoxic doses of an industrial pesticide emulsifier and subsequently are infected with sublethal doses of mouse-adapted human influenza b (lee) virus (flub). the purpose of this study was to determine whether liver lipid content was altered in the mice, the time course of any changes, and whether lipid changes were consistent with liver pathology. neonatal mice exposed dermall ... | 1987 | 3600198 |
| [the 1985 influenza epidemic in a pediatric practice]. | because it is not possible to distinguish clinically influenza from other respiratory infections, virological methods have to be used to establish the influenza etiology. nasopharyngeal swabs from 202 children with respiratory symptoms were taken. influenza a virus (h3n2) was isolated from 44 children, influenza a virus (h1n1) from 61 children and influenza b virus from 13 children. the maximal activity of the two influenza a virus subtypes was different. the following features permitted the cla ... | 1987 | 3600670 |
| primary structure of the polymerase acidic (pa) gene of an influenza b virus (b/sing/222/79). | a dna copy of influenza b/singapore/222/79 viral rna segment 3 containing the gene coding for the polymerase acidic (pa) protein has been cloned in escherichia coli plasmid pbr322, and its nucleotide sequence has been determined. the cdna clone was incomplete and contained 1810 nucleotides (nt 396 to 2205). the remaining nucleotide sequence at both 5' and 3' ends of b pa gene was obtained by sequencing the viral rna (minus sense) and messenger rna (plus sense) using oligonucleotide primers. the ... | 1987 | 3604058 |
| [physiochemical properties of purified and virion neuraminidases of the influenza b viruses]. | a method for isolation of neuraminidase using pronase has been developed. purified preparations have been recovered from two influenza b virus strains, b/mass/3/66 and b/ussr/14/80. physico-chemical properties of neuraminidases were compared; optimal conditions for the determination of neuraminidase activity of these strains were determined. strains differences in thermostability, optimal ph, specificity to substrates were established. neuraminidases, isolated or present in virions, were shown t ... | 1987 | 3604184 |
| [clinical evaluation of trivalent influenza virus split vaccine in patients with cardiovascular diseases]. | | 1987 | 3604322 |
| [significance of legionella pneumophila in human respiratory pathology]. | the etiological structure of acute pneumonia and acute respiratory diseases was studied with a view to establishing the proportion of l. pneumophila among other causative agents of such diseases. a total of 299 patients were examined over time. the etiological diagnosis based on the data of serological examination was made in 70.6% of the patients with acute pneumonia and in 65% of the patients with acute respiratory viral infections and influenza. in the etiology of pneumonia, the leading role ... | 1987 | 3604505 |
| [etiology of acute pneumonias in an organized collective]. | in this work the immune structure of an organized group with respect to acute respiratory infections and the etiological structure of cases of acute pneumonia was studied. the sera taken from 602 persons were tested for the presence of antibodies to 14 infective agents of the viral, bacterial and mycoplasmal nature. the data indicate that all these agents circulate in the group under study with the prevalence of influenza a (h3n2), influenza b and group iii parainfluenza viruses. among etiologic ... | 1987 | 3604507 |
| upper respiratory tract viral infection and mucociliary clearance. | twenty-six normal volunteers were exposed to rhinovirus or influenza b virus. measurement of nasal mucociliary clearance, ciliary beat frequency, percent of epithelium ciliated, ciliary ultrastructure and nasal transmucosal potential difference were made before exposure, during viral incubation and at the time of expected overt infection. ten volunteers failed to become infected, six were subclinically infected and nine were infected with symptoms. there were no significant differences between t ... | 1987 | 3609187 |
| unusual outbreak of influenza a in a wyoming nursing home. | an explosive outbreak of influenza a (h3n2) occurred during early february 1985 among the 55 residents of a nursing home in douglas, wyoming. thirty of the 55 (55%) had febrile respiratory illnesses. thirty-six (65%) had received influenza vaccine. the attack rate was 84% in unvaccinated and 39% in vaccinated persons. vaccine efficacy was estimated to be 54%. there were eight cases of pneumonia in unvaccinated and four in vaccinated persons, three deaths in unvaccinated and one death in vaccinat ... | 1987 | 3611565 |
| leads from the mmwr. prevention and control of influenza. | | 1987 | 3612978 |
| children hospitalized with influenza b infection. | an outbreak of influenza virus type b infection occurred in philadelphia from december, 1985, to april, 1986. during this epidemic 24 patients were admitted to children's hospital from whom influenza b was isolated from routine respiratory viral cultures. all were younger than 3 years of age. clinical findings included fever (greater than or equal to 38 degrees c) (88%), rhinorrhea (62.6%), cough (50%), otitis (50%), rhonchi (42%), vomiting (38%), diarrhea (33%), rales (21%), pharyngitis (13%) a ... | 1987 | 3615069 |
| influenza at lowry air force base in denver, 1982-1986. | | 1987 | 3624907 |
| comparison of one- and two-dose regimens of influenza vaccine for elderly men. | in november and december 1984, 102 male residents of a long-term care facility (mean age 74.6 [extremes 59 and 97] years) received 0.5 ml of trivalent inactivated whole-virion influenza vaccine, containing 15 micrograms of the hemagglutinin of each of a/philippines/2/82 (h3n2), a/chile/83 (h1n1) and b/ussr/83. a second dose of the vaccine was administered to a subgroup of 55 randomly chosen subjects 8 weeks later. serum samples were collected from all the subjects before and 4, 8, 12 and 16 week ... | 1987 | 3651943 |
| immunization of elderly people with two doses of influenza vaccine. | a total of 104 elderly patients were immunized with one or two doses of the commercial 1985-1986 inactivated influenza vaccine formulation. two types of vaccines (split virus [sv] vaccine and whole virus [wv] vaccine) and one or two doses 1 month apart were given. no difference in local or systemic reactions was noted among the four groups. the reciprocal geometric mean hemagglutination inhibition antibody titers against influenza a/philippines/82 (h3n2) after one or two doses were: 78 for sv va ... | 1987 | 3654947 |
| epidemiologic particularities of influenza in 1986 in a large urban centre of romania. | the study presents the evolutive peculiarities of the epidemiologic influenza process in 1986 in a large urban centre in romania, inferrable from the active control by a complex methodology based on clinical, epidemiologic and laboratory investigations. the prevalent part of a (h1n1 and h3n2) and b influenza viruses in causing seasonal morbidity risings is being stressed. a (h3n2) and b influenza viruses determined an epidemic rising during the first trimester and a (h1n1) and a (h3n2) during th ... | 1987 | 3660584 |
| [comparative study of the rna-polymerase activity of non-pathogenic and pathogenic influenza viruses a and b]. | activity of rna polymerase was studied in original non-pathogenic for mice viruses of influenza a and b (a/seal/massachusetts 1/80, a/ussr 05/81, a/philippines 2/82 and b/singapore 227/79) and of their pathogenic derivatives. all the non-pathogenic viruses studied exhibited the low rate of transcriptase activity. pathogenic derivatives of these strains exhibited higher activity of rna polymerase, which was 1.5-3-fold higher as compared with the original strain. during passage of influenza viruse ... | 1987 | 3660748 |
| nucleotide sequences of the pa and pb1 genes of b/ann arbor/1/66 virus: comparison with genes of b/lee/40 and type a influenza viruses. | the complete sequences of the pa and pb1 genome rna segments of b/ann arbor/1/66 virus have been determined. the pa vrna is 2308 bases long. its complementary rna has a single open reading frame of 2187 bases, capable of encoding a pa protein of 726 amino acids with a molecular weight of 83,175 da. the predicted pa polypeptide has an overall net charge of -7.5 at ph 7.0. the pb1 vrna is 2369 bases long. its complementary rna has a single open reading frame of 2277 bases, capable of encoding a pb ... | 1987 | 3660943 |
| the hemagglutinins of the human influenza viruses a and b recognize different receptor microdomains. | a cryptically i-active sialylglycoprotein (glycoprotein 2) isolated from bovine erythrocyte membranes as sendai virus receptor (suzuki, y., suzuki, t. and matsumoto, m. (1983) j. biochem. 93, 1621-1633) contains n-glycolylneuraminic acid (neugc) as its predominate sialic acid and exhibits poor receptor activity for a variety of influenza viruses. enzymatic modification of asialoglycoprotein-2 to contain n-acetylneuraminic acid (neuac) in the neuac alpha 2-3gal and neuac alpha 2-6gal sequences us ... | 1987 | 3663654 |
| [a study on the epidemic characteristics of influenza in qingdao]. | | 1987 | 3664615 |
| influenza surveillance in pune (india) during 1983-85. | | 1987 | 3666849 |
| two cases of influenza b encephalitis. | | 1987 | 3668577 |
| leads from the mmwr. update on influenza activity--worldwide. | | 1987 | 3669252 |
| [virological and serological diagnosis of influenza using the passive hemagglutination and passive hemagglutination inhibition tests]. | | 1987 | 3673027 |
| influenza b encephalitis. | | 1987 | 3686990 |
| a sero-epidemiological study of conventional infectious agents in alzheimer's disease. | serum antibody titres to adenovirus, chlamydia group b, coxiella burnettii, cytomegalovirus, herpes simplex virus, influenza a, influenza b, measles and mycoplasma pneumoniae were measured in 33 patients with a clinical diagnosis of alzheimer's disease, and in 28 non-demented controls suffering from functional psychiatric disorders. no statistically significant differences were found between the patients and controls, and it is concluded that these agents play no role in the aetiology of alzheim ... | 1987 | 3687571 |
| effect of influenza b virus on nutrient transport in cultured epithelial cells. | the possibility that influenza virus could induce changes in membrane permeability to nutrients ordinarily concentrated within the cell was examined. madin-darby canine kidney cells were infected with egg-grown influenza b virus at 37 degrees c and ph 7.4 (a condition in which influenza virus enters cells by endocytosis). control cells were mock-infected with allantoic fluid from chick embryos. transport of phosphate, 2-deoxyglucose, and alpha-aminoisobutyric acid was measured at various interva ... | 1987 | 3695411 |
| influenza c virus uses 9-o-acetyl-n-acetylneuraminic acid as a high affinity receptor determinant for attachment to cells. | identification of the receptor-destroying enzyme of influenza c virus as a specific neuraminate o-acetylesterase has suggested that 9-o-acetyl-n-acetylneuraminic acid is an essential component of the cell surface receptor of influenza c virus (herrler, g., rott, r., klenk, h.-d., muller, h.-p., shukla, a. k., and schauer, r. (1985) embo (eur. mol. biol. organ.) j. 4, 1503-1506). in this report, three common sialic acids, n-acetylneuraminic acid (neuac), n-glycollylneuraminic acid (neugc), and 9- ... | 1986 | 3700379 |
| [assessment of the effectiveness of inactivated influenza vaccines for adults]. | in 9 controlled epidemiological observations (1977-1984) the effectiveness of modern soviet whole-virion vaccines was studied in organized groups of adults and at industrial enterprises. during the epidemic outbreaks of influenza of different etiology and intensity morbidity rate in influenza and acute respiratory diseases was shown to decrease 1.1-2.2 times among the vaccinees, depending on the correspondence of epidemic and vaccine influenza strains. the absence of influenza virus b in inactiv ... | 1986 | 3705814 |
| [smoke cloud pneumonia, a new atypical pneumonia in influenza diseases]. | since 1980 we have to reckon with a novel atypical pneumonia in influenzae. the clinical course of these fire-damp pneumonias is very discrete. in x-ray the changes of the lungs are uniform in density and considerably multiform in extent, in which cases the topographic-anatomic borderlines are not taken into consideration. they disappear within 6 to 8 days. there are no participations of pleura and hilus. | 1986 | 3716517 |
| genome analysis of influenza b virus strains isolated during epidemics in boarding schools. brief report. | genetic analysis of influenza b virus strains isolated during concurrent epidemics (february-march 1982) in three physically separated schools was carried out using the rna:rna hybridization technique. the data supports the hypothesis that the influenza b virus epidemics in each school were initiated by different viruses and the variability of the strains in a closed community was found to be minor though some variants were detected. | 1986 | 3718236 |
| occurrence of influenza antibodies in addis ababa. | | 1986 | 3720736 |
| superiority of tissue-culture-grown antigens over egg-grown antigens for serologic diagnosis of influenza b virus infections. | acute and convalescent sera obtained from 10 adults and 21 children who were infected with influenza b virus were tested by hemagglutination inhibition. of four antigens used, two tissue-culture-grown antigens were superior to either egg-grown or egg-grown, ether-treated antigens in detecting fourfold antibody rise during influenza b virus infection. | 1986 | 3723116 |
| immunogenicity of a single dose of trivalent influenza vaccine including a/philippines (h3n2): results of a field trial. | during 1982, a new a(h3n2) influenza virus subtype, a/philippines/2/82, was identified, and this strain was combined with previous a(h1n1) and b influenza virus strains in the trivalent inactivated vaccine recommended for the 1983-1984 influenza season. prior to the widescale use of this vaccine in israel, a group of 106 young male soldiers was vaccinated under controlled conditions. before vaccination, antibody titers greater than or equal to 1:40 were found in 14.1% against a/philippines (h3n2 ... | 1986 | 3723117 |
| effects of selenazofurin and ribavirin and their 5'-triphosphates on replicative functions of influenza a and b viruses. | we studied the effects of selenazofurin alone and in combination with ribavirin on replication of influenza a and b viruses. these drugs showed little cytotoxicity as measured by leucine incorporation into protein in mdck cells, although they were potent inhibitors of viral replication in the same cells. selenazofurin inhibited growth of influenza a and b viruses at concentrations (50% inhibitory dose = 25 and 19 microm, respectively) which were similar to those at which growth was inhibited by ... | 1986 | 3729336 |
| isolation of a novel type of interfering influenza b virus defective in the function of m gene. | a novel type of interfering influenza b virus which is defective in the function of m gene has been reported. clone 301, a b type virus clone obtained by successive back-crosses of a/aichi/2/68 (h 3 n 2) with b/yamagata/1/73, grew normally in mdck cells when inoculated at a low multiplicity, but was easily converted to a hemagglutinating but non-infectious form by one cycle of high multiplicity infection. within mdck cells infected with infectious clone 301 at a high multiplicity, synthesis of m ... | 1986 | 3729727 |
| influenza in canada in 1985-86. | | 1986 | 3730999 |
| statement on influenza vaccination for the 1986-87 season. | | 1986 | 3731000 |
| immunobiological activities of nontoxic lipid a: enhancement of nonspecific resistance in combination with trehalose dimycolate against viral infection and adjuvant effects. | the ability of nontoxic monophosphoryl lipid a (mpl) to stimulate nonspecific resistance against viral infection was investigated. mice pretreated intravenously with squalane-in-water emulsions of mpl, alone or in combination with other immunostimulants, were given an aerosol of influenza virus three weeks after the pretreatment. complete protection against lethal influenza virus infection was conferred when mpl was combined with trehalose dimycolate (tdm). the protective activity of mpl plus td ... | 1986 | 3733302 |
| electroelution for purification of influenza a matrix protein for use in immunoassay. | a new preparative method for isolation of matrix protein from type a influenza virus was developed. commercially available whole virus or split virus vaccines were lysed, and the soluble proteins separated by electrophoresis on polyacrylamide gel. the matrix protein was located on the gel by precipitation with kcl, and recovered by electroelution. the method was technically simple and required little direct supervision during the two-step recovery process. yields of a matrix were consistently hi ... | 1986 | 3734011 |
| leads from the mmwr. current trends. influenza--united states, 1985-1986 season. | | 1986 | 3735640 |
| serum lipid abnormalities in a chemical/viral mouse model for reye's syndrome. | neonatal mice given nontoxic dermal applications of an industrial surfactant, toximul mp8 (tox), and subsequently infected with sublethal doses of mouse-adapted human influenza b (lee) virus (flub) develop many of the biochemical features of reye's syndrome (rs). to determine whether these also include abnormal circulating lipid, we examined serum lipid profiles in the mouse model throughout the treatment course using iatroscan-th10. following 10 days of exposure to surfactant, serum phospholipi ... | 1986 | 3736346 |
| recommendations for prevention and control of influenza. recommendations of the immunization practices advisory committee. centers for disease control, department of health and human services. | these recommendations of the immunization practices advisory committee update for 1986-1987 the information on the vaccine and antiviral agent available for control of influenza. changes include addition of statements about: updating of the influenza strains in the vaccine for 1986-1987; immunization and amantadine prophylaxis for household members who provide home care for high-risk persons; optimal time for conducting routine vaccination programs; concurrent administration of influenza vaccine ... | 1986 | 3740679 |
| [allergenic action of inactivated influenza vaccines]. | the allergenic action of influenza vaccines was evaluated by the determination of the capacity of sera, taken before and after immunization, for inducing the degranulation of rat mast cells in the presence of the vaccine preparation. in this test sera from three groups of volunteers immunized with experimental and commercial batches of influenza inactivated vaccines, purified and concentrated by gradient centrifugation, was studied. the absence of immediate-type allergization after a single admi ... | 1986 | 3751403 |
| influenza b virus pb1 protein; nucleotide sequence of the genome rna segment predicts a high degree of structural homology with the corresponding influenza a virus polymerase protein. | the complete nucleotide sequence of a cloned cdna copy of the genome rna segment encoding the influenza b/lee/40 virus pb1 polymerase protein has been determined. the genome rna segment is 2368 nucleotides in length and is capable of encoding a polymerase (pb1) protein of 752 amino acids with a calculated mol mass of 84,407 da. as expected, the protein is highly basic with a net charge of +20 at ph 7.0. sequence comparison between the influenza a and b virus pb1 proteins reveals that they share ... | 1986 | 3754992 |
| prevention of influenza, 1986-1987. | | 1986 | 3762489 |
| [haemophilus influenzae b meningitis detected by a quick-diagnosis cerebrospinal fluid test]. | | 1986 | 3763211 |
| hemophilus influenzae type b cellulitis in adults. | cellulitis due to hemophilus influenzae type b is a rare but treatable event in adults. herein is described a 67-year-old woman with anterior neck cellulitis caused by h. influenzae type b, documented by positive blood culture results. six additional cases reported in the literature are reviewed. the following clinical syndrome emerges: the patient is usually older than 50 years of age, and pharyngitis develops first, followed by the onset of high fever and rapidly progressive anterior neck swel ... | 1986 | 3766601 |
| influenza virus-specific antibody-secreting cells in the murine lung during primary influenza virus infection. | an enzyme-linked immunosorbent plaque assay is described which can reliably enumerate influenza virus-specific antibody-secreting cells and exhibits specificity similar to that of the indirect enzyme-linked immunosorbent assay. the assay was used to characterize the development of specific antibody-secreting cells, principally within lung tissue, during primary murine influenza virus infection after intranasal inoculation. cells secreting influenza virus-specific immunoglobulin m (igm), igg, and ... | 1986 | 3773053 |
| [enzymologically different characteristics between influenza a and b virus neuraminidases]. | | 1986 | 3776104 |
| [antiviral action of a polyphenol complex isolated from the medicinal plant geranium sanguineum l. ii. its inactivating action on the influenza virus]. | | 1986 | 3776705 |
| reye's syndrome in adults. a case report and review of the literature. | adult reye's syndrome (ars) is an infrequently diagnosed condition that typically affects patients younger than age 35 years. we describe a 61-year-old man with ars occurring after influenza b-ussr infection and aspirin use. the diagnosis of ars was confirmed by oil-red-o stain of liver biopsy tissue and subsequent electron microscopy. we review the literature on ars and compare the clinical features and management of ars with pediatric rye's syndrome. this case is of interest to practitioners t ... | 1986 | 3778077 |
| influenza in the united kingdom 1982-85. | influenza surveillance in the uk between the years 1982 and 1985 has demonstrated the regular winter appearance of influenza a virus of both h1n1 and h3n2 subtypes and influenza b. their antigenic diversity is described and correlated with the national statistics for morbidity and mortality for influenza. one unexpected finding has been that despite the wide circulation of influenza viruses there has been a continuation of winters without significant increases in influenza deaths or morbidity. a ... | 1986 | 3782786 |
| [comparative analysis of the nucleocapsids formed in the cells in a double heterotypic influenza infection]. | | 1986 | 3785258 |
| nucleotide sequence of rna segment 7 of influenza b/singapore/222/79: maintenance of a second large open reading frame. | the nucleotide sequence of rna segment 7 of influenza b/singapore/222/79 has been determined. the deduced amino acid sequence of the m1 protein indicates that it contains 248 amino acids of which 243 are identical in the b/lee/40 m1 protein. a second overlapping open reading frame with a maximum coding region of 195 amino acids has also been maintained in the 39 years separating the two isolates. the deduced amino acid sequence of the second coding region displays 86% homology with the comparabl ... | 1986 | 3788064 |
| influenza b virus model of reye's syndrome. evidence for a nonpermissive infection of liver and brain. | nonpermissive or abortive viral infections seldom have been recognized as damaging to organs. concentrated infectious influenza b/lee virus injected intravenously into balb/c mice causes a microvesicular fatty metamorphosis of the liver and produces many features of reye's syndrome. evidence for a nonpermissive infection in brain and liver includes the following points: (a) no viral replication occurs in either organ; (b) no inflammation develops; (c) no virions are seen by electron microscopy; ... | 1987 | 3795869 |
| laboratory studies of the 1984 influenza epidemic on the witwatersrand. | a particularly severe outbreak of influenza occurred on the witwatersrand from may to august 1984, caused sequentially by influenza a (h3n2), b/influenza and influenza a (h1n1) viruses. although the precise extent of the infection was impossible to determine, valuable anecdotal information was provided by a network of sentinel sampling stations in private practices, clinics and hospitals, representing a cross-section of population groups on the witwatersrand. this active surveillance programme w ... | 1986 | 3798269 |
| influenza activity in czechoslovakia and the ussr, 1980-1985. | between 1980 and 1985, czechoslovakia had experienced 4 and the ussr 3 major influenza outbreaks. of the 3 epidemic outbreaks in the ussr, 2 were associated with influenza b virus (in the 1980/81 and 1983/84 seasons) and 1 with influenza a virus of the h3n2 subtype. in the ussr, influenza a (h1n1) virus never predominated as a cause of epidemic during the 5 years period. in czechoslovakia, 2 epidemics (in the 1980/81 and 1983/84 seasons) were due to influenza a (h1n1) virus. the epidemic in the ... | 1986 | 3805712 |
| toxic shock syndrome. a newly recognized complication of influenza and influenzalike illness. | nine cases of severe hypotension or death compatible with toxic shock syndrome (tss) as a complication of influenza and influenzalike illness were identified in minnesota with onsets between jan 2, 1986, and feb 23, 1986, in which five of the patients died. during this time, an influenza outbreak was occurring in the state. cultures of respiratory secretions were performed in eight patients; staphylococcus aureus was isolated from all of them. seven s aureus isolates were available for determina ... | 1987 | 3806893 |
| [activity of virion rna-polymerase in influenza a and b virus variants with different pathogenicities for mice]. | rna polymerase activities in parental strains of influenza a and b viruses nonpathogenic for mice and their pathogenic variants have been studied. the parental strains are a/seal/massachusetts 1/80, a/ussr 05/81, a/philippines 2/82, b/singapore 222/79. the rna polymerase activity has been also studied in recombinant strains obtained by crossing various parental strains, one of which is pathogenic for mice (ar/pr 8/34), and having different degrees of pathogenicity. the nonpathogenic viruses had ... | 1986 | 3807928 |
| infectious influenza a and b virus variants with long carboxyl terminal deletions in the ns1 polypeptides. | an influenza a virus, a/turkey/oregon/71, was shown by protein gel analysis to code for an ns1 protein approximately half the size of those of other influenza a viruses. sequence analysis of the ns gene of this virus revealed a 10 nucleotide deletion resulting in an ns1 protein of only 124 amino acids. this truncated ns1 polypeptide retained its karyophilic pattern as detected by indirect immunofluorescence analysis of virus infected cells. also, a/turkey/oregon/71 virus grew to high titer in em ... | 1987 | 3811235 |
| effects of site-specific mutation on structure and activity of influenza virus b/lee/40 neuraminidase. | a cdna copy of the neuraminidase (na) gene of a high-growing reassortant influenza virus which has the hemagglutinin of b/hong kong/8/73 and the na of b/lee/40 was cloned into plasmid puc 9 and subcloned into a late-replacement sv40 vector so that the na gene could be expressed in eukaryotic cells. the expressed protein was antigenically and enzymatically active. to study structure-function relationships in the b/lee na, particularly in comparison to the known structure of influenza a (n2) na, s ... | 1987 | 3811237 |
| possible association of mycoplasma and viral respiratory infections with bacterial meningitis. | the presence of viral infection was evaluated in 160 children older than three months with bacterial meningitis who were admitted to children's medical center or parkland memorial hospital, dallas, tx, between october 1979 and march 1982. results were compared with a single serologic specimen in 138 children without meningitis. a recent history of upper respiratory infection was obtained from 60% of patients, including 10/13 with pneumococcal, 9/16 with meningococcal, and 77/131 with haemophilus ... | 1987 | 3812456 |