| primary gene products of an arbovirus. | | 1969 | 4310764 |
| antiviral substances in plants of the mint family (labiatae). 3. peppermint (mentha piperita) and other mint plants. | | 1967 | 4290278 |
| in vitro studies on the antiviral activity of 1, 3-bis(2-chloroethyl)-1-nitrosourea. | chemotherapy experiments carried out in vitro demonstrated that 1,3-bis(2-chloroethyl)-1-nitrosourea (bcnu) was active against lymphocytic choriomeningitis virus and had an equivocal antiviral effect on semliki forest, herpes simplex, and vaccinia viruses. no antiviral effect was observed with bcnu against western equine encephalomyelitis, polio, and parainfluenza (ha-1) viruses. activity of the drug was determined by inhibition of viral-induced cytopathogenic effect in kb or chick embryo cells ... | 1966 | 4291237 |
| isolation of polyoma virus and semliki forest virus from tissue culture fluid by continuous flow zonal ultracentrifugation. | | 1967 | 4295378 |
| specific inhibition of virus growth in cells treated with phospholipase c. | | 1968 | 4297337 |
| isolation of a transmissible agent resembling rubella virus from an apparently healthy human embryo lung cell culture. | | 1968 | 4297605 |
| induction of the interferon system by various inducers. | | 1968 | 4297700 |
| the use of batch-type zonal ultracentrifuge rotors for the isolation and purification of viruses. | | 1968 | 4300107 |
| virucidal properties of dimethyl sulfoxide. | | 1968 | 4300900 |
| behaviour of infectious rna from four different viruses in continuously subcultured aedes aegypti mosquito embryo cells. | | 1969 | 4302398 |
| [stimulation of viral multiplication by anti-interferon serum: influence on the number of plaques]. | | 1968 | 4302943 |
| [on the problem of the role of migratory birds in the circulation of arboviruses]. | | 1967 | 4237202 |
| investigations on the effect of ascorbic acid on antibody production in rabbits after injection of bacterial and viral antigens by different routes. | | 1970 | 4249965 |
| [detection of antibodies to a series of arboviruses of groups a, b and bunyamwera on the territory of the georgian ssr]. | | 1972 | 4260426 |
| induction of interferon by formaldehyde inactivated influenza viruses in the mouse. | | 1974 | 4282986 |
| rapid titration of viral hemagglutinins and hemagglutination inhibition antibodies with the aid of a fragiligraph. | | 1965 | 4284691 |
| [persistance of a stimulated character in primitive virus cultivated in the presence of anti-interferon serum]. | | 1969 | 4308446 |
| electrophoretic properties of foot-and-mouth disease virus strains and the selection of intra-strain mutants. | | 1969 | 4308489 |
| antiviral and cytotoxic effects of mycophenolic acid. | | 1969 | 4308492 |
| relative sensitivities of viruses to different species of interferon. | some viruses were found to be more sensitive than others to the action of interferons from certain species of animals but less sensitive to interferons from other species. vaccinia virus was the most sensitive to mouse and hamster interferons of five viruses tested, but the least sensitive of these five viruses to human, rabbit, and bat interferons. the relative sensitivities of the viruses to interferons were found to be characteristic for each of the species tested, with those closely related ... | 1969 | 4308914 |
| interferon and cyclic-3'5'-adenosine monophosphate: potentiation of antiviral activity. | | 1969 | 4309119 |
| enhanced virus yields and decreased interferon production in mycoplasma-infected hamster cells. | | 1969 | 4309471 |
| conditional lethal mutants of animal viruses. | | 1969 | 4310910 |
| induction of the interferon mechanism by single-stranded rna: potentiation by polybasic substances. | | 1969 | 4311213 |
| antiviral action of gliotoxin. | | 1969 | 4313024 |
| interferon production by mouse peritoneal cells. | | 1970 | 4314245 |
| antiviral activity of chlorite-oxidized oxyamylose, a polyacetal carboxylic acid. | intraperitoneal injection of chlorite-oxidized oxyamylose (coam) protected mice against mengo, vaccinia, semliki forest, and influenza apr8 viruses. topical administration in the eye of rabbits partially inhibited the development of experimental herpetic keratoconjunctivitis. coam resembled polyacrylic acid in many aspects, but it was markedly less toxic. for systemic administration, the therapeutic index was on the order of magnitude of 1:300 to 1:500. although the in vivo antiviral effect of c ... | 1970 | 4314554 |
| production of crude human interferon with high specific activity. | | 1972 | 4338797 |
| inhibition of sindbis virus production by media of low ionic strength: intracellular events and requirements for reversal. | incubation of sindbis virus-infected cultures in medium with an ionic strength of 0.105 reduced the virus yield more than 99%. this inhibition was rapidly reversed by exposing the cultures to normal medium: within 20 min the previously inhibited cultures had released as much infectious virus as normal controls had produced during hours of incubation. the following intracellular processes were essentially normal in inhibited, infected monolayers: protein and phospholipid synthesis, the synthesis ... | 1970 | 4315161 |
| interferon stimulation and other phenotypic properties of two variants of polyoma virus. | | 1969 | 4315857 |
| antiviral activity of double stranded rna from a virus isolated from aspergillus foetidus. | | 1970 | 4316959 |
| an adhesive surface sampling technique for airborne viruses. | a mixture of sucrose, glycerol and bovine serum albumin produces a stable coating in a petri dish which remains adhesive for up to an hour when exposed in a slit sampler. virus aerosols can be collected on this surface followed by the direct addition of cell cultures to demonstrate the presence of viable virus. the technique is applicable to the andersen sampler. a modified version of this sampler has been produced with the same particle collection efficiency as the standard andersen sampler. th ... | 1970 | 4317107 |
| tilorone hydrochloride: an orally active antiviral agent. | tilorone hydrochloride, 2,7-bis[2-(diethylamino)ethoxy]fluoren-9-one dihydrochloride, given orally to mice before they are infected is active against at least nine viruses of both rna and dna groups. the compound is effective when given prophylactically; the optimum time of treatment depends on the route of infection. | 1970 | 4317923 |
| [a precipitating antigen in the blood of mice infected by arboviruses]. | | 1970 | 4319532 |
| [a study of the antiviral and interferonogenic activity of various copolymers of vinylpyrrolidone]. | | 1968 | 4304409 |
| effect of raphanin on the multiplication of some rna and dna viruses in, and interferon production by, cultured cells. | | 1968 | 4306944 |
| transfer of interferon-producing macrophages: new approach to viral chemotherapy. | mice were protected from infection with semliki forest virus and encephalomyocarditis virus by the transfer of peritoneal macrophages that were stimulated to produce interferon in vitro by exposure to a nonreplicating virus. this method of therapy was also utilized in animals infected with encephalomy-ocarditis virus after onset of clinical signs. of these animals 40 percent recovered, but only 9 percent of the control group recovered. | 1970 | 4319682 |
| inverse relationship of interferon production and virus content in cell lines from burkitt's lymphoma and acute leukemias. | | 1969 | 4307376 |
| viral auto-inhibition studied by the effect of anti-interferon serum on plaque formation. | | 1970 | 4321448 |
| a novel substituted guanidine with high activity in vitro against rhinoviruses. | | 1973 | 4357165 |
| induction of interferon by bacterial vaccines and allergenic extracts. | | 1971 | 4325036 |
| effect of antilymphocytic serum on circulating interferon in mice as a function of the inducer. | | 1971 | 4325471 |
| inhibition of interferon synthesis in phospholipase c treated primary chick embryo cells. | | 1971 | 4327713 |
| the lipid class composition of semliki forest virus and plasma membranes of the host cells. | | 1971 | 4331728 |
| effect of mycoplasmas on virus replication and plaque formation in mouse cells. | | 1972 | 4332334 |
| yellow fever vaccine. iv. reactogenicity and antibody response in volunteers inoculated with a vaccine free from contaminating avian leukosis viruses. | | 1972 | 4333781 |
| attempts to demonstrate the interferon defense mechanism in cultured mosquito cells. | | 1974 | 4369796 |
| antiviral agents. 5h-as-triazino(5,6-b) indoles. | | 1972 | 4333824 |
| effect of concanavalin a on cells infected with enveloped rna viruses. | | 1972 | 4334774 |
| inhibition of the multiplication of enveloped rna-viruses by glucosamine and 2-deoxy-d-glucose. | | 1972 | 4336520 |
| difference in interferon response and protection from ocular virus infection in rabbits and monkeys. | | 1972 | 4338613 |
| broad-spectrum antiviral activity of virazole: 1-beta-d-ribofuranosyl-1,2,4-triazole-3-carboxamide. | virazole is a synthetic nucleoside active in tissue culture against at least 16 dna and rna viruses. applied topically, it inhibits herpetic keratitis in rabbits and tail lesions induced by herpes, vaccinia, and vesicular stomatitis viruses in mice. injected intraperitoneally into mice, it inhibits splenomegaly and hepatomegaly induced by friend leukemia virus and respiratory infections caused by influenza a(o), a(2), and b viruses and parainfluenza 1 virus. infections is also effective. | 1972 | 4340949 |
| isolation and identification of the virus-specified rna species found on membrane-bound polyribosomes of chick embryo cells infected with semliki forest virus. | | 1972 | 4341056 |
| fatty chains of different lipid classes of semliki forest virus and host cell membranes. | semliki forest virus was grown in bhk-21 cells. the major classes of phospho-and glycolipids of the virus were analyzed for the compositions of fatty acids, aldehydes, and sphingosine bases, and the major glycerophospholipids were analyzed for the relative proportions of alkenyl-acyl, alkyl-acyl, and diacyl forms. all viral lipid classes proved to be mixtures of several molecular species. each class contained a characteristic mixture of fatty chains, which was different in all other classes. all ... | 1972 | 4342051 |
| membrane-associated replication complex in arbovirus infection. | cytoplasmic extracts of chicken embryo fibroblast cells infected with semliki forest virus were subjected to isopycnic centrifugation in discontinuous sucrose gradients. seven distinct bands were usually formed. the four upper bands contained predominantly smooth membranes and the lowest band was enriched in rough endoplasmic reticulum. one fraction (fraction 5), banding at a density of 1.16 g/cm(3), was found to be heavily enriched in pulse-labeled ribonucleic acid (rna), viral rna polymerase, ... | 1972 | 4342056 |
| [effect of polyelectrolytes on virus reproduction]. | | 1972 | 4342656 |
| intrinsic interference between different enveloped rna viruses. | | 1972 | 4346650 |
| morphogenesis of c-type and a-type particles in cells infected by an arbovirus. | | 1973 | 4348224 |
| influence of deae-dextran on plaque production by semliki forest virus. | | 1968 | 4385161 |
| host defenses during primary venezuelan equine encephalomyelitis virus infection in mice. i. passive transfer of protection with immune serum and immune cells. | | 1973 | 4348975 |
| study of two double-stranded ribonucleic acids of viral origin: interferon inducing and antiviral activities. | | 1972 | 4349828 |
| isolation and characterization of virus-resistant mouse embryo fibroblasts. | | 1973 | 4355331 |
| investigations into yellow fever virus and other arboviruses in the northern regions of kenya. | previous studies having shown an appreciable level of yellow fever immunity to exist in northern kenya, further epidemiological and serological surveys were carried out there in 1968 in an attempt to define more clearly the distribution of yellow fever and to locate possible vector and reservoir hosts of the disease; these surveys also provided information on a number of other arboviruses.altogether 436 sera from 5 areas in northern kenya were screened by haemagglutination-inhibition tests with ... | 1970 | 4393661 |
| characterisation of the 3'-terminus of sindbis virion rna. | | 1973 | 4357110 |
| the production of interferon by animal viruses. | | 1971 | 4396263 |
| relative antiviral resistance induced in homologous and heterologous cells by cross-reacting interferons. | human cells incubated with human interferon become more resistant to vesicular stomatitis virus (vsv) than to semliki forest virus (sfv); monkey cells treated with monkey interferon become more resistant to sfv than to vsv. however, monkey cells incubated with human interferon developed relative antiviral activity identical to that induced by homologous interferon, and human cells developed characteristic human interferon-induced relative antiviral activity when exposed to monkey interferon. the ... | 1970 | 4322082 |
| enhanced resistance of mice to virulent japanese b encephalitis virus following inactivated vaccine and poly i:c. | | 1970 | 4323444 |
| some factors affecting the survival of airborne viruses. | | 1971 | 4324730 |
| herpes simplex infection of hep-2 and l-929 cells. 2. the kinetics of virus multiplication and cell lysis, and the measurement of interferon production. | | 1972 | 4361838 |
| n,n-dioctadecyl-n',n'-bis(2-hydroxyethyl) propanediamine: antiviral activity and interferon stimulation in mice. | cp-20,961, n,n-dioctadecyl-n', n'-bis(2-hydroxyethyl)propanediamine, is an antiviral drug with low acute toxicity in mice. parenteral injection of this compound protected mice against lethal infections with encephalomyocarditis and semliki forest viruses and effectively suppressed pox formation by vaccinia infection. maximal antiviral effects were observed when cp-20,961 was administered 6 to 12 h before infection. an interferon detected in plasma 12 to 20 h after the drug was given appeared to ... | 1973 | 4364178 |
| virion-bound protein kinase in semliki forest and sindbis viruses. | semliki forest virus and sindbis virus (alphaviruses belonging to the togavirus group) grown in bhk-21 cells possessed very low levels of virion-associated protein kinase activity. for comparison, vesicular stomatitis virus, also grown in bhk-21 cells, contained a virion-bound protein kinase which had a specific activity 80 times greater than that of the alphaviruses. the alphavirus protein kinase was unmasked by the nonionic detergent nonidet p-40 but was not activated by cyclic nucleotides. ph ... | 1974 | 4364899 |
| inactivation of some bacterial and animal viruses by exposure to liquid-air interfaces. | | 1974 | 4367307 |
| appearance of cytotoxic t cells in cerebrospinal fluid of mice with ectromelia virus-induced meningitis. | | 1974 | 4368424 |
| in vitro synthesis of structural proteins of semliki forest virus directed by isolated 26 s rna from infected cells. | | 1974 | 4368800 |
| bis-basic-substituted polycyclic aromatic compounds. a new class of antiviral agents. 1,2 6. bis-basic-substituted fluoranthenes. | | 1974 | 4369817 |
| metabolic effect of interferon preparations and some interferon inducers: activation of adenylate cyclase system. | | 1974 | 4372863 |
| antiviral activity of an ether-extracted nonviable preparation of brucella abortus. | extraction of living brucella abortus (strain 456) with aqueous ether yielded a nonviable, insoluble residue (bru-pel). when injected into mice, bru-pel was an effective, nontoxic interferon stimulus. mice pretreated with bru-pel were protected against challenge with otherwise lethal doses of semliki forest virus. significant protection was afforded when bru-pel was given as many as 7 days before virus challenge. evidence is presented dealing with the complex nature of bru-pel and with the possi ... | 1974 | 4373393 |
| [determination of the interferon level in the blood, conjunctival washings and urine of patients with herpetic keratoiridocyclitis treated with interferonogen]. | | 1974 | 4375945 |
| use of frozen chick and duck embryo cells for plaque assays of arboviruses and rickettsiae. | | 1974 | 4376554 |
| study on experimental vaccinia virus infection in mice with special reference to host defence mechanisms. | | 1974 | 4377639 |
| comparison of the effect of caseinase c and pronase on the hemagglutinating activity and on the infectivity of semliki forest virus. | | 1965 | 4379480 |
| morphological modifications of semliki forest virus after treatment with pronase. | | 1966 | 4381340 |
| plating efficiency of semliki forest virus; influence of caseinase c treatment of the virus. | | 1966 | 4381985 |
| plaque production by group a arboviruses. i. influence of deae-dextran on plaques under agar and agarose. plaque production under carboxymethylcellulose. | | 1967 | 4383397 |
| the growth of arboviruses in mosquito cells in vitro. | | 1968 | 4385155 |
| failure of dimethylsulfoxide to enhance experimental viral infection in laboratory animals. | | 1969 | 4388869 |
| arbovirus haemagglutinin: inactivation by high pressures. | | 1969 | 4389037 |
| inactivation of viruses by phenethyl alcohol at temperatures below and above 0 degrees c. | | 1969 | 4389654 |
| ricefield development and arbovirus epidemiology, kano plain, kenya. | | 1970 | 4394987 |
| delayed onset of encephalitis in mice passively immunised against semliki forest virus. | | 1971 | 4398234 |
| requirement of cellular rna-synthesis for the inhibition of semliki forest virus by poly (ri)-poly (rc). | | 1972 | 4402633 |
| isolation of plasma membrane and endoplasmic reticulum fragments from chick embryo fibroblasts. | | 1972 | 4403128 |
| [detection of hemagglutination-inhibiting antibodies to arboviruses in sera of young individuals in the federal republic of germany and in the republic of togo (west africa)]. | | 1971 | 4403535 |
| target-organ treatment of neurotropic virus disease with interferon inducers. | interferon inducers were used against vaccinial encephalitis to study the target-organ treatment of neurotropic disease and to correlate interferon levels and the antiviral state following such treatment. a 45-mug amount of statolon, 30 mug of polyribinosinic-polyribocytidylic acid complex (poly i.poly c), or 0.0154 ha unit of sendai virus given intracerebrally protected 100% of mice challenged the next day with 1,000 median lethal doses (ld(50)) of vaccinia virus. significant protection against ... | 1972 | 4404669 |
| interferon production in arbovirus-infected cell cultures of tortoise (testudo graeca) kidney. | | 1973 | 4405393 |
| possible mechanisms for the transport of semliki forest virus into and within mouse brain. an electron-microscopic study. | | 1974 | 4427113 |
| cross-linking of the spike glycoproteins in semliki forest virus with dimethylsuberimidate. | | 1974 | 4432371 |
| [proceedings: ribonucleic acids of semliki forest virus]. | | 1974 | 4444826 |
| [proceedings: polyadenylic acid segments in the ribonucleic acids of semliki forest virus]. | | 1974 | 4444827 |
| limited infection of mouse brain cell cultures with semliki forest virus. | | 1974 | 4447795 |