| calcium requirement for the alpha-action of catecholamines on guinea-pig taenia coli. | | 1977 | 19747 |
| structural requirements for opioid activity of analogues of the enkephalins. | | 1977 | 19753 |
| irreversible blockade of the histamine response in depolarized smooth muscle. | | 1977 | 19761 |
| prolactin release inhibiting and stimulating factors in the hypothalamus. | catecholamines, especially norepinephrine and dopamine, as well as gaba extracted from porcine hypothalamic tissue, were found to possess pif activity in vitro. however, more work is needed to determine whether or not the effects of gaba or catecholamines on prolactin release are physiological or pharmacological. until such studies are completed and until the chemical nature and biological roles of other substances with pif activity found in the hypothalamus are clarified, no conclusion as to th ... | 1977 | 19952 |
| effect of nitrites and nitrates on various aspects of vitamin nutritional status. | nitrites--and sometimes nitrates--decrease the biological availability of dietary vitamins in several animal species. 1. numerous studies show that ingested nitrites decrease the stock of liver vitamin a in nonruminants (rat, pig, chicken); the effect of nitrates is less pronounced even lacking. in vitro, experiments allow to think that vitamin a and beta-carotene can be destroyed by nitrites in the diet and/or in the gastrointestinal tract. 2. some recent works--those of lhuissier particularly- ... | 1976 | 20023 |
| quantitative composition of the gastrointestinal flora in the young pig. | studies were conducted into the quantitative composition of the gastro-intestinal flora in clinically intact store pigs. the methods are described in greater detail, followed by presentation of results. in the discussion particular reference is made to literature. conclusions are drawn regarding the topographic distribution of the various germ groups in the gastro-intestinal tract of the store pig. | 1977 | 20068 |
| species differences in erythrocyte resistance against decrease of ph values. | | 1977 | 20076 |
| methods for estimating aluminum sorption to skin. | | 1977 | 20078 |
| bufuralol, a new beta-adrenoceptor blocking agent in a series of benzofuran-2-ethanolamines. part 2: pharmacology. | 1-(7-ethylbenzofuran-2-yl)-2-tert.-butylamino-1-hydroxyethane hydrochloride (bufuralol) is a non-selective beta-adrenoceptor blocking agent which closely resembles propranolol in its properties, including potency. bufuralol is devoid of alpha-adrenoceptor blocking activity but possesses beta-adrenoceptor agonist activity. beta-adrenoceptor blocking activity resides mainly in the (-)-isomer though membrane stabilising properties are associated with both optical isomers. | 1977 | 20114 |
| pharmacological studies of o-chloro-alpha-(tert.-butylamino)methylbenzylalcohol hydrochloride (c-78), a new bronchodilator. ii. actions on the cardio-vascular system and smooth muscle organs. | | 1977 | 20115 |
| the role of divalent cations in the activation of the nadp+-specific isocitrate dehydrogenase from pisum sativum l. | a divalent cation electrode was used to measure the stability constants (association constants) for the magnesium and manganese complexes of the substrates for the nadp+-specific isocitrate dehydrogenase (ec 1.1.1.42) from pea stems. at an ionic strength of 26.5 mm and at ph 7.4 the stability constants for the mg2+-isocitrate and mg2+-nadp+ complexes were 0.85 +/- 0.2 and 0.43 +/- 0.04 mm-1 respectively and for the mn2+-isocitrate and mn2+-nadp+ complexes they were 1.25 +/- 0.07 and 0.75 +/- 0.0 ... | 1977 | 20207 |
| electrolyte levels and net fluid and electrolyte movements in the gastrointestinal tract of weanling swine. | electrolyte concentrations, osmolality and ph were determined in conventionally raised weanling swine fed a liquid diet. incorporation of a dilution marker into the diet in combination with frequent feeding enabled estimations as to the sites of relative fluid and electrolyte absorption and secretion along the gastrointestinal tract. unlike many other species the weanling pig depends largely on its large intestine for absorption of fluid and electrolytes with small changes in net fluid movement ... | 1977 | 20210 |
| soterenol and related compounds: molecular modifications and changes in selectivity, affinity and efficacy at beta-adrenoreceptors in guinea-pig atria and trachea. | | 1977 | 20258 |
| a comparison of the circadian rhythms and concentrations of serotonin and norepinephrine in the telencephalon of four rodent species. | | 1977 | 20266 |
| xenogeneic neoplastic transplants in adult rats pretreated with thymic foetal extracts. | the paper deals with the effect of thymic extracts from young foetal pigs and calves on the development of tumour xenografts, i.e. mouse ascites ehrlich carcinoma and hamster malignant melanoma, in rats. the results of experiments showed that ehrlich carcinoma developed in 4 out of 72 animals, i.e., in those animals which had received thymic extracts from young foetal pigs, ehrlich carcinoma led to their death. ehrlich carcinoma assumed a solid form and the cells changed in their shape. it devel ... | 1977 | 20339 |
| new method of biologically assaying active substances in mixtures using the cascade technic of washing isolated detector organs. | | 1977 | 20391 |
| appearance of the uterine specific proteins following induction of ovulation in prepubertal gilts. | the appearance of the uterine specific proteins following induction of ovulation in prepubertal gilts is described. 12 gilts each at 3, 4, and 5 months of age were allotted randomly to 1 of 2 treatment groups prior to induction of ovulation: 1) saline treated and 2) human chorionic gonadotropin (hcg) treated (400 iu daily from days 12 through 16 of the induced cycle). ovulation was induced with hcg following treatment with pregnant mare serum gonadotropin and the day of ovulation was designa ... | 1977 | 20437 |
| daily changes in the blood of conscious pigs with catheters in foetal and uterine vessels during late gestation. | 1. catheters were inserted into the foetal carotid artery and maternal middle uterine artery and vein in twenty foetuses from fifteen sows, 91-105 days pregnant. blood samples were collected from foetal and maternal circulations for periods of 7-21 days after surgery.2. blood gas tensions, ph, packed cell volume (pcv) and the levels of glucose, fructose and lactic acid in conscious pigs were followed in foetal and maternal bloods during late pregnancy.3. foetal blood gas tensions, ph, pcv, lacti ... | 1977 | 20500 |
| ph dependence of catalysis of the monomer of hog kidney d-amino acid oxidase. | | 1976 | 20559 |
| tricyclic antidepressant drugs block histamine h2 receptor in brain. | | 1977 | 20581 |
| labeling immunoelectrophoresis: a general method for increasing the sensitivity of rocket immunoelectrophoresis with 125i-labeled anti-antibodies. | in a new procedure, rocket immunoelectrophoresis is performed at ph 8.7 with rabbit antibodies and 5% polyethyleneglycol 6000 in the agarose gel. after the ph in the gel has been changed to 5 the nonprecipitated immunoglobulins are electrophorsed out of the gel simultaneously with the electrophoresis of 125i-labeled swine antibodies against rabbit igg into the gel. the latter antibodies tag the rabbit igg, which is not present only in the precipitates. the radioactive precipitates are visualized ... | 1977 | 20657 |
| some effects of crude venom from the cones conus striatus and conus magus on isolated guinea-pig atria. | | 1977 | 20679 |
| platelet adhesion to foreign surfaces under controlled conditions of whole blood flow: human vs rabbit, dog, calf, sheep, pig, macaque, and baboon. | our results reveal significant differences between mammalian species with respect to platelet adhesion to foreign surfaces exposed to heparinized, flowing blood. in particular, we have demonstrated the following: 1) at a surface shear rate characteristic of shear rates in mammalian arteries, human platelet adhesion (and that of calf, baboon, macaque, hog or sheep) is negligible in comparison to dog or rabbit platelet adhesion after 10 mins of blood flow. 2) the species differences are biomateria ... | 1977 | 20686 |
| liver circulation and metabolism in haemorrhagic shock. an experimental study with special reference to the effect of glucagon. | | 1977 | 20724 |
| comparative pharmacological studies of n-(2-benzhydryloxyethyl)homomorpholine (linadryl h), linadryl and benadryl. i. antihistaminic, anticholinergic and spasmolytic effects of linadryl h. | | 1977 | 20737 |
| local anesthetic contracture and relaxation of airway smooth muscle. | | 1977 | 20826 |
| demonstration of beta-lipotropin activating enzyme in porcine pituitary. | | 1977 | 20892 |
| mitochondrial ca2+ metabolism in aortic smooth muscle of swine. effect of mild hypercholesterolemia. | | 1977 | 20901 |
| porcine malignant hyperthermia. v: fatal hyperthermia in the pietrain pig, associated with the infusion of alpha-adrenergic agonists. | the effects of the administration of noradrenaline alone, and noradrenaline with either phentolamine or propranolol, on thermogenesis and substrate mobilization were investigated in six pietrain (mh-susceptible) and six large white (unsusceptible) pigs. the infusion of noradrenaline alone produced a significantly increased lipolytic response and a significantly decreased hyperglycaemic response in pietrain pigs compared with the large white breed. although noradrenaline alone produced only a sma ... | 1977 | 20913 |
| interactions of tetrahymena dynein with microtubule protein. tubulin-induced stimulation of dynein atpase activity. | the atpase (ec 3.6.1.3) activity of 30 s dynein from tetrahymena cilia was remarkably stimulated by porcine brain tubulin at ph 10. the activity increased with increasing concentration of tubulin until the molar ratio of tubulin dimer to 30 s dynein reached approx. 10. the optimum of the atpase activity of 30 s dynein in the presence of tubulin was 1-2 mm for mgcl2 and 2 mm for cacl2. increasing ionic strength gradually inhibited the stimulation effects of tubulin. activation energies of 30 s dy ... | 1977 | 20950 |
| circular dichroism of porcine, bovine, and equine pancreatic phospholipases a2 and their zymogens. unusual conformations simulating helix content. | | 1977 | 20973 |
| immunoelectrophoretic studies on pig intestinal brush border proteins. | brush borders were prepared from pig intestinal mucosa and the membrane proteins solubilized with either triton x-100 or papain. proteins, thus released, were used as antigens to raise antisera in rabbits. the immunoglobulin g fractions were isolated and shown by the double layer immunofluorescence staining technique to react only with the brush border region of the enterocyte. the antibodies obtained were used in immunoelectrophoretic studies on the brush border proteins. eight hydrolytic activ ... | 1977 | 20974 |
| effect of tyrosine ionization upon biological activities of angiotensin ii and two new peptide analogues. | the role of the tyrosine side-chain in the smooth muscle contracting activity of angiotensin iii was investigated by determining intrinsic activities and ed50 values of 4-(3-chlorotyrosine)angiotensin ii and 4-(3-benzyltyrosine)angiotensin ii in the isolated guinea-pig ileum and rat uterus. 4-(3-chlorotyrosine)angiotensin ii activity was compared with that of angiotensin ii at different ph values, in which the ratio of their degrees of phenolic ionization varied. the results indicated that depro ... | 1977 | 20979 |
| alterations in temperature and histamine receptor function. | | 1977 | 21104 |
| ganglion blocking activity of a series of semisynthetic quaternary pyrrolizidines. | | 1977 | 21136 |
| enumeration of t rosette-forming cell population in rabbit peripheral blood using human, sheep, guinea-pig, rat, mouse and chicken red blood cells under different experimental conditions. | attempts were made to estimate peripheral t-lymphocytes in rabbits by their ability to form rosettes with sheep, human, guinea-pig, rat, mouse and chicken rbc. the reaction was studied under different conditions of ph and temperature. the test was also carried out in the presence or absence of glutaraldehyde. with sheep rbc, lymphocytes from 2 of the 5 rabbits studied formed rosettes to the extent of 1.5% in the system containing glutaraldehyde. these results however were not reproducible when s ... | 1977 | 21220 |
| evidence from agonist and antagonist studies to suggest that the beta1-adrenoceptors subserving the positive inotropic and chronotropic responses of the heart do not belong to two separate subgroups. | the positive inotropic and chronotropic responses of guinea-pig isolated left and right atria to 17 sympathomimetic amines were examined under conditions selected to control the pharmacological environment. each agonist was compared with (--)-isoprenaline as the reference by constructing dose-response curves. equiactive molar concentration ratios relative to (--)-isoprenaline were calculated at the ec50 for rate and tension responses. statistical analysis revealed that (--)-noradrenaline and (+/ ... | 1977 | 21238 |
| effects of dantrolene sodium on isolated skeletal, smooth and cardiac muscle of the guinea-pig. | | 1977 | 21244 |
| effect of tazolol on beta-adrenoceptors in isolated preparations of the guinea-pig and rat. | | 1977 | 21245 |
| possible mechanism of action of beta-phenethylamine in migraine. | | 1977 | 21252 |
| influence of pyridylisatogen tosylate on contractions produced by atp and by purinergic stimulation in the terminal ileum of the guinea-pig. | 2-2'pyridylisatogen tosylate (pit), which antagonizes the inhibitory action of atp in the taenia caeci, did not antagonize the excitatory effects of exogenous atp and of purinergic stimulation of the terminal guinea-pig ileum. pit (0-5--2-5 mum) potentiated the atp-induced contractions and also the contractions produced by potassium chloride, though the potentiation could not be related to the dose in every experiment. the responses to noradrenaline, adrenaline and histamine were slightly inhibi ... | 1977 | 21258 |
| analysis of the beta-receptor mediated effect on slow-contracting skeletal muscle in vitro. | subtetanic contractions of the guinea-pig isolated soleus, a slow-contracting skeletal muscle, were evoked by transmural field-stimulation. isoprenaline caused a dose-dependent depression of the contractions. this effect was inhibited by propranolol and h 35/25 (1-(p-tolyl-2-isopropylamino-1-propanol) but not by practolol. similar results were obtained for terbutaline. tazolol and h 80/62 (1-isopropylamino-3-(p-hydroxyphenoxy)-2-propanol (hcl), selective beta1-agonists, had no effect per se but ... | 1977 | 21260 |
| effects of some drugs on the circular muscle of the isolated lower oesophagus. | | 1977 | 21262 |
| prolonged safe aortic clamping by combining membrane stabilization, multidose cardioplegia, and appropriate ph reperfusion. | | 1977 | 21327 |
| lipogenic enzyme activity in relation to fat accumulation. | | 1977 | 21364 |
| confirmation of conductance increase by adrenalin in the guinea-pig taenia coli (alpha-action). | | 1977 | 21402 |
| experimental study on the h1 and h2 histamine receptors. | | 1977 | 21423 |
| the potentiating effect of alpha-adrenergic blocking drug on the action of bronchodilators (author's transl). | | 1977 | 21431 |
| sensitization of contracted tracheal smooth muscle to beta-adrenergic spasmolysis by subthreshold doses of papaverine. | in certain cases beta-adrenergic substances cause little or no relaxation of tracheal or bronchiolar smooth muscles contracted by spasmogenic mediators. this phenomenon is explained on the basis of the model of functional antagonism, with the suppositions that the spasmogenic system has a reserve and the spasmogen concentrations are much higher than the concentration which would cause a just-maximal contraction. if this is correct, the model predicts that it should be possible to restore the eff ... | 1977 | 21448 |
| a rapid fluorometric assay of angiotensin-converting enzyme. | a rapid, simple and sensitive method is described for the fluorometric assay of angiotesin-converting enzyme using fluorescamine. the critical factors such as optimal ph, incubation time, chloride ion, and inactivation by edta and 8-hydroxyquinoline were examined. the km value for hippuryl-l-histidyl-l-leucine was 0.5 mm. this method was applied to the assay of angiotensin-converting enzyme in the rat serum and the reproducible values were obtained with a 10 mul of the rat serum. | 1977 | 21470 |
| anti-arrhythmic, antianginal and cardiovascular effects of the beta receptor blocking agent te-176 (chinoin-103). | | 1977 | 21516 |
| histometrical aspects of testicular ontogenesis in the normal and unilateral cryptorchid pig proceedings. | | 1977 | 21520 |
| cholesterol ester: lysolecithin acyltransferase activity of the aorta. | | 1977 | 21525 |
| participation of phospholipids in arterial metabolism of cholesterol esters. | | 1977 | 21526 |
| metabolism of phosphatidic acid and phosphatidylinositol in relation to transmitter release from synaptosomes. | | 1977 | 21530 |
| homocarnosinase: a hog kidney dipeptidase with a broader specificity than carnosinase. | | 1977 | 21630 |
| acid-base status in the blood of domestic pigs during exhausting locomotor stress of small and medium intensity. | twenty-two fattening pigs were stressed until their rectal temperatures had reached 42 degrees c. the means of stress included walking on moving conveyor belt at ambient temperatures between 22 degrees c and 27 degrees c and relative humidities between 69 and 98%, belt speeds of 0.7 m/s, 1.3 m/s or 0.7 m/s, and stimulation by means of a forcing rod. rectal temperature, respiratory frequency, lactic acid level in blood plasma, ph, as well as pco2 and base excess in the blood were measured prior t ... | 1977 | 21642 |
| sila analogs of meflophenhydramine. | | 1977 | 21643 |
| effect of substrates and effectors on the reversible inactivation of pig spleen phosphofructokinase by adenosine triphosphate. | 1. to investigate the mechanism of the reversible inactivation of pig spleen phosphofructokinase by atp, the effect of order of addition of reactants (substrates, effectors and enzyme solution) was studied by preincubating the enzyme before assay with various combinations of its substrates and effectors. 2. preincubation of the enzyme with mgatp or atp at ph7.0 before addition of fructose 6-phosphate caused a rapid and much greater inhibition of activity than that observed when the reaction (car ... | 1977 | 21659 |
| effect of dihydroergotoxine on activities of beta-receptor stimulators. | the effect of dihydroergotoxine (det), an alpha-receptor blocker, on the bronchodilating effect of various beta-receptor stimulators was examined using the isolated guinea-pig tracheal smooth muscle. relaxation of isolated guinea-pig tracheal smooth muscle with isoproterenol hydrochloride, salbutamol hemisulfate and clorprenaline hydrochloride, was markedly increased by continous infusion of det. this result may suggest that det, an alpha-receptor blocker, can be used together with bronchodilato ... | 1977 | 21668 |
| histomorphometric aspects of testicular morphogenesis in the naturally unilateral cryptorchid pig. | | 1977 | 21707 |
| changes in serum lh concentrations during normal and abnormal sexual development in the pig. | serum levels of luteinizing hormone (lh) were determined in fetal and prepubertal pigs from day 49 postcoitum to 25 weeks of age, and also in unilaterally cryptorchid, freemartin and castrated pigs of similar ages. serum lh was undetectable in the second trimester of pregnancy, but then gradually increased up to 2 weeks after birth in both sexes. 2-week-old pigs showed irregular lh peaks exceeding 2 ng/ml. serum lh concentrations decreased during the 3rd and 4th weeks of life. mean lh concen ... | 1977 | 21708 |
| studies on a new beta-adrenoceptor blocker, 6-(2-hydroxy-3-isopropylamino)propoxy benzothiazole succinate (kf-577). | | 1977 | 21752 |
| the use of liver transglutaminase for protein labeling. | | 1977 | 21793 |
| release of spasmogens from rat isolated lungs by tryptamines. | tryptamine and 5-hydroxytryptamine (5-ht) infused through the pulmonary circulation of rat isolated lungs released a spasmogen resembling slow reacting substance of anaphylaxis which we have denoted srs-t and a pge-like activity. srs-t was not extractable from krebs solution by several organic solvents at neutral or acid ph. it is therefore unlike other types of srs activity. the pge-like release had a threshold at about 2 microgram/ml of tryptamine or 5-ht and did not increase with increasing d ... | 1977 | 21802 |
| isolation of ph-optima and apparent michaelis constants of highly purified enzymes from human and animal sources. comparison of enzymes of human and animal origin, i. | enzymes from animal sources are frequently used for quality control of enzyme activity determination in clinical chemistry. for this purpose they should be very similar to human enzymes. it is shown that preparations of enzymes of diagnostic interest from human and porcine organs, purified in exactly the same way, have very similar ph-optima and apparent michaelis constants for their substrates. | 1977 | 21934 |
| indolizine derivativatives with biological activity iii: 3-(3-aminopropyl)-2-methylindolizine, 3-(3-aminopropyl)-2-methyl-5,6,7,8-tetrahydroindolizine, and their n -alkyl derivatives. | the syntheses and a preliminary pharmacological evaluation of some aminopropylindolizines and aminopropyltetrahydroindolizines are reported. all compounds showed anti-5-hydroxytryptamine, anti-histamine, and antiacetylcholine activities. some also exhibited weak cns activity. | 1977 | 21953 |
| a benzoaquinolizine derivative with a neuroleptic-like action on cerebral monoamine turnover. | | 1977 | 21955 |
| establishment of the hosts of bloodsucking mosquitoes in abkhazia. 3. fertility of females of mass mosquito species feeding on warm-blooded and cold-blooded animals. | | 1977 | 22029 |
| amino acid transmitters (author's transl). | | 1977 | 22097 |
| induction of the enzymes related to neurogenic amines (author's transl). | | 1977 | 22098 |
| cyclic nucleotides in brain cells (author's transl). | | 1977 | 22099 |
| current aspects of the study of stomach ulcer in swine. | | 1977 | 22156 |
| resting metabolism of lactate in starved and fed pigs. | | 1977 | 22176 |
| modification of mucus in animal models of disease. | | 1977 | 22224 |
| the distribution of enzymes in the epidermis of the domestic cat. | with the help of enzyme histochemical methods, the distribution and activities of several oxidative and hydrolytic enzymes in the epidermis of the densely-haired domestic cat have been studied. distinct oxidative enzyme activity could be demonstrated in all epidermal layers except the stratum corneum. among the hydrolytic enzymes investigated, strong reactions for non-specific esterases were visible especially in the str. granulosum and the basal lamellae of the str. corneum. positive reactions ... | 1977 | 22312 |
| investigation of the bronchoconstriction induced by beta-adrenoceptor blocking drugs in guinea-pigs and rats proceeding. | | 1977 | 22371 |
| neurotransmitter-sensitive adenylate cyclase in the hypothalami of guinea-pig, rat and monkey. | | 1977 | 22390 |
| sex-limited and sex-modified genetic defects in swine--cryptorchidism. | review of published data suggests that cryptorchidism in chester whites and yorkshires is caused by completely penetrant, recessive genes at two autosomal loci; in lacombes, multifactorial modes of inheritance are more plausible. different genetic systems control presence of the trait vs. number of sides affected; left testes are retained more often in almost all samples. contrary to previous claims prenatal viability of homozygous males and females is normal. genes causing cryptorchidism are un ... | 1977 | 22396 |
| purinergic transmission. | | 1977 | 22431 |
| characterization of the adrenergic activity of carbuterol (sk&f 40383-a). | carbuterol is a beta-adrenergic bronchodilator with selectivity for bronchial smooth muscle relative to cardiac and vascular tissues of several species including man. the present studies were undertaken to further characterize its adrenergic profile. in vitro studies demonstrated that carbuterol was a direct acting beta-adrenergic agonist, not dependent on endogenous catecholamine release, and was devoid of alpha-adrenergic agonist activity. the activity of the racemate was shown to reside prima ... | 1977 | 22441 |
| oxatomide, a new orally active drug which inhibits both the release and the effects of allergic mediators. | oxatomide is a new potent inhibitor of anaphylactic and allergic reactions. after oral administration, the compound both inhibits the release of endogenous histamine and prevents the effects of exogensous histamine, at comparable doses. the combination of these effects appears to be the basis of the effectiveness of oxatomide in allergic reactions and may lead to clinical application different from classical antihistaminics and from cromoglycate. | 1977 | 22455 |
| peripheral cardiovascular dopamine receptors. | | 1977 | 22476 |
| changes in the microflora and physiology of the anterior intestinal tract of pigs weaned at 2 days, with special reference to the pathogenesis of diarrhea. | the gastrointestinal microflora and gastric physiology of piglets weaned at 2 days was compared with that of piglets allowed to continue sucking the sow. although there was a significantly higher count of escherichia coli in the stomach, duodenum, and jejunum of the early-weaned compared with sow-reared pigs, these differences were not detectable in samples from the ileum. there were no quantitative differences in lactobacilli and in streptococci between the two treatments. lactobacillus ferment ... | 1977 | 22488 |
| association-dissociation of the flavoprotein hog kidney d-amino acid oxidase. determination of the monomer-dimer equilibrium constant and the energetics of subunit association. | the enzyme concentration dependence of spectrophotometric titrations of hog kidney d-amino acid oxidase ec 1.4.3.3 with p-aminobenzoate was studied. the monomer-dimer equilibrium constant of the oxidized holoenzyme at 25 degrees c was estimated to be 7 x 10(5)m-1 at ph 7.5 and 4x 10(6)m-1 at ph 8.3. the energetics of subunit association are discussed. | 1977 | 22539 |
| the mechanism of the release of prostaglandin-like activity from guinea-pig isolated ileum. | | 1977 | 22612 |
| an analysis of the inhibitory effects and of possible prostaglandins antagonism of chloroquine in the guinea-pig isolated ileum. | | 1977 | 22625 |
| antidotal action of the oxime hs6 at the soman poisoned neuromuscular junction of the rat and guinea-pig. | | 1977 | 22626 |
| bupropion hydrochloride ((+/-) alpha-t-butylamino-3-chloropropiophenone hcl): a novel antidepressant agent. | | 1977 | 22628 |
| receptors involved in inhibition of the response to acetylcholine released from the myenteric plexus of the guinea-pig ileum proceedings. | | 1977 | 22656 |
| the selective positive inotropic activity of 2-alkyl-1,3-dioxo-5,10-dihydroimidazo1,5-bisoquinolines proceedings. | | 1977 | 22713 |
| changes in muscarinic ligand binding to intestinal muscle strips produced by pre-exposure to hypotonic conditions. | the extent of the binding of 3hpropylbenzilylcholine mustard (3h-prbcm) to muscarinic receptors in longitudinal muscle strips from guinea-pig small intestine is increased by nearly 50% when the strips are preexposed to distilled water before measurement of 3h-prbcm binding in krebs-henseleit solution. the apparent rate constant for 3h-prbcm-receptor complex formation is more than double that of intact strips. the curves for the inhibition of 3h-prbcm binding by methylatropinium bromide in normal ... | 1978 | 22721 |
| interaction of mucins with calcium, h+ ion and albumin. | | 1976 | 22809 |
| regulation of energy metabolism in brown adipose tissue mitochondria (author's transl. | | 1977 | 22849 |
| hormones and behaviour. | | 1977 | 22868 |
| properties of membrane-bound and soluble guanylate cyclase of cardiac and skeletal muscle. | kinetic properties of guanylate cyclase present in the washed particles, plasma membranes, and the soluble cytoplasm of heart and skeletal muscle are described; properties of the enzyme solubilized by triton x-100 treatment of the particles or membrane fractions are also reported. it is apparent from the data that the membrane-bound guanylate cyclase in the cell may be regulated by acetylcholine, may exist as a metallo-protein with bound mn2+ (essential for activity), and that mg2+ regulates, wh ... | 1976 | 22902 |
| experimental liver failure. a comparison between hepatectomy and hepatic devascularization in the pig. | difficulties in the treatment of acute hepatic failure due to insufficient knowledge of the pathogenesis and the impredectability of the course has made an experimental model desirable. a number of such models have been proposed, among these hepatectomy and total hepatic devascularization. in the present study hepatectomy and total hepatic devascularization have been compared, as it has been doubted if hepatectomy, not including necrotic liver tissue, is a valid model of human hepatic failure. n ... | 1977 | 22974 |
| the first cleavage site in pepsinogen activation. | by incubation of porcine, bovine, canine, or chicken pepsinogens and calf prochymosin with pepstatin at ph 2.5, the first active protein generated on activation is trapped in an inactive complex. the first activation peptide liberated from porcine pepsinogen has been identified as residues 1-16 whereas that from prochymosin is derived from residues 1-27. this suggests that pepsin and chymosin are not formed by one-step conversions from their zymogens, but by (different) sequential, activation me ... | 1977 | 22994 |
| intramolecular activation of pepsinogen. | two pathways for pepsinogen activation have been demonstrated. intramolecular activation, which is kinetically first-order, predominates over the autocatalytic pathway if the ph is below 3 and the protein concentration is less than 1 mg/ml during activation. intramolecular pepsinogen activation is inhibited either by pepstatin, a potent pepsin inhibitor, or by purified globin from hemoglobin, a good pepsin substrate. also, pepsinogen at ph 2 can be bound to a pepstatin-sepharose column and recov ... | 1977 | 22999 |
| metabolic and pharmacologic interactions on the bronchial tonus. | after reminding data concerning the part played by the as a rule antagonist camp system in moticity of the smooth muscle fibers in general and of the bronchial fibers in particular, the authors study the different types of interaction on bronchial muscular fibers which have been discribed. it is concerning the adrenergic fibers that the experimental and clinical data are prevalent (role of bronchial alpha- and beta2- receptors) and the authors point especially to their own studies performed sinc ... | 1977 | 23051 |