| the pharmacological properties of a new, orally active antianaphylactic compound: ketotifen, a benzocycloheptathiophene. | | 1978 | 35171 |
| neuropharmacological profile of clobazam, a new 1',5'-benzodiazepine [proceedings]. | | 1979 | 35200 |
| an experimental model to investigate disinhibitory mechanisms in penicillin epileptogenesis. | | 1978 | 35336 |
| cardiac arrhythmias produced by bretylium in cats anesthetized with halothane. | bretylium given by rapid intravenous injection into cats anesthetized solely with halothane precipitates severe and unusually long-lasting ventricular arrhythmias. they are observed 20-70 sec following doses of bretylium ranging from 0.8 mg/kg to 15 mg/kg and last for 60 sec to just over half an hour. bretylium also manifests signs of sympathetic involvement since it raises blood pressure and heart rate just prior to the onset of arrhythmias. propranolol pretreatment prevents bretylium arrhythmi ... | 1979 | 35358 |
| [effect of tranquilizers on impulse conduction in the afferent pathways of visceral nerves]. | experiments on pyrolaxon-immobilized cats evidence that diazepam produces depression of evoked potentials in the specific, nonspecific and associative brain structures upon an electric stimulation of the visceral and somatic nerves, and also with accoustic and photostimulation; meprotan (meprobamate) in doses of 40-100 mg/kg neither changes nor increases, and in doses of 100-150 mg/kg, reduces the amplitude of evoked potentials and at the sme time forces down the arterial pressure. amizyl (benac ... | 1979 | 35365 |
| effects of several centrally active drugs on the sleep-wakefulness cycle of cats. | | 1979 | 35763 |
| [the synthesis and pharmacologic properties of n-alkylester homologs of d,1-2-phenylglycine]. | | 1978 | 35797 |
| effects of thioproperazine and sulpiride on the locomotor rhythms in the decorticate cat. | the decorticate cat develops sequences of locomotor movements, especially in the two posterior limbs: those appear either spontaneously, or following a single shock applied to l7 dorsal root. using this preparation, we tested the effects of two neuroleptic agents, thioproperazine (tz) and sulpiride (s), through either systemic administration or local injection into the lateral-posterior hypothalamus and into the lumbar spinal cord. tz administered i.v. (0.5 mg/kg) suppressed all locomotor rhythm ... | 1979 | 35804 |
| experimental infection of putorius eversmanni polecats and martes foina martens with tahyna virus. | three putorius eversmanni pole-cats and two martes foina martens aged about 9 months were subcutaneously infected with about 260 suckling mouse ld50 of the extraneurally passaged "236" strain of tahyna virus (california group, genus bunyavirus). viraemia with maximal titres of 1.32 (pole-cats) and 1.28 (martens) dex intraperitoneal (i.p.) mouse ld50/0.02 ml was demonstrated from 48 to 96 hr after inoculation (p.i.). by the plaque-reduction neutralization test, seroconversion was demonstrated 15 ... | 1978 | 35949 |
| cow red blood cells. ii. stimulation of bovine red cell glycolysis by plasma. | cow red cell glycolysis, which can be stimulated by a variety of purines and pyrimidines, was also found to be elevated by its own plasma. dialyzed or charcoal-treated plasma could no longer stimulate glycolysis, suggesting that the stimulating factors may be purines or pyrimidines. determination of purines or pyrimidines in plasma revealed the presence of xanthine (0.31 mum), hypoxanthine (0.60 mum), and adenosine (0.05 mum), as well as unknown compounds. a physiologic level of hypoxanthine, wi ... | 1979 | 35980 |
| schizophrenia-like psychosis after treatment with beta-blockers. | | 1979 | 36198 |
| hypotensive mechanism of adrenergic alpha blockers in cats. | the hypotensive mechanism of adrenergic alpha blockers is related to their inhibitory effect on the contractile ca-mechanism in vascular smooth muscles as in nitroglycerin or verapamil. | 1979 | 36291 |
| small bowel absorption of sulfasalazine and its hepatic metabolism in human beings, cats, and rats. | to elucidate the role of the small bowel and liver in sulfasalazine (sasp) metabolism, we performed studies in patients, cats, and rats. the role of the small bowel in absorption and metabolism of sasp was determined by the amount of administered sasp excreted in ileostomy effluents, and the concentration of serum and urinary sasp and its metabolites, sulfapyridine and 5-amino salicylic acid. seventy-five to ninety percent of the drug was excreted in ileostomy effluents of 6 patients as sasp, an ... | 1979 | 36326 |
| dibenzepin as an antifibrillatory agent for spontaneously terminating electrically induced ventricular fibrillation. | the effect of dibenzepin, a tricyclic antidepressant drug, on electrically induced ventricular fibrillation was studied in 20 cats and nine dogs. the ventricular fibrillation threshold and the ability of the ventricle to defibrillate spontaneously were determined before and after the administration of dibenzepin, with each animal serving as its own control. the drug raised the ventricular fibrillation threshold in all the animals tested. before treatment, spontaneous ventricular defibrillation o ... | 1979 | 36362 |
| fluid therapy in shock. | | 1979 | 36369 |
| further studies of glucocorticoid effects on spinal cord function: single and repetitive monosynaptic transmission and apparent ia afferent transmitter turnover. | | 1979 | 36476 |
| ca2+ control of electrolyte permeability in plasma membrane vesicles from cat pancreas. | the influence of ca2+ and other cations on electrolyte permeability has been studied in isolated membrane vesicles from cat pancreas. ca2+ in the micromolar to millimolar concentration range, as well as mg2+, sr2+, mn2+ and la3+ at a tested concentration 10(-4) m, increased na+ permeability when applied at the vesicle inside. when added to the vesicle outside, however, they decreased na+ permeability. ba2+ was effective from the outside but not from the vesicle inside. when ca2+ was present at b ... | 1979 | 36481 |
| synaptic transmission in a model for stochastic neural activity. | | 1979 | 36505 |
| clinical use of piperacetazine to modify behavior in dogs and cats: a practitioner's viewpoint. | | 1979 | 36711 |
| studies on the transmitters of the afferent and efferent pathways of the striatum and their interaction in the baboon, cat and rat. | | 1979 | 36837 |
| effects of alpha-adrenoceptor agonists on peripherally evoked parasympathetic submaxillary salivation in the cat [proceedings]. | | 1979 | 36955 |
| biochemical processes involved in ferrihemoglobin formation by monohydroxyaniline derivatives in erythrocytes of birds and mammals. | | 1979 | 37027 |
| properties of norepinephrine n-methyltransferase from rat, cat and chicken brain. | | 1979 | 37032 |
| beta-adrenoceptor blockade by atenolol, metoprolol and propranolol in the anaesthetized cat. | the inhibitory effects of atenolol, metoprolol and propranolol on isoprenaline-induced tachycardia, broncho-relaxation and vasodilatation were investigated in the reserpinized and anaesthetized cat. in low doses all three antagonists inhibited the heart rate response to isoprenaline, the order of potency being propranolol greater than metoprolol greater than atenolol. while propranolol inhibited the bronchodilation and vasodilation responses to isoprenaline in the same dose range as it blocked t ... | 1979 | 37096 |
| organization and transfer of heterologous chloramphenicol and tetracycline resistance genes in pneumococcus. | the cat and tet genes of chloramphenicol- and tetracycline-resistant clinical isolates of streptococcus pneumoniae from paris and japan were shown to be contained in adjacent heterologous insertions into the chromosome. the two insertions transformed laboratory strains at frequencies that were low, unequal, and, for tet, very sensitive to the length of the donor deoxyribonucleic acid strand. in contrast, the transforming activity of cat was relatively stable. there was an unusual asymmetric cotr ... | 1979 | 37238 |
| some effects of ph on plasma calcium in the human and cat [proceedings]. | | 1979 | 37331 |
| fibroblast and epidermal growth factors: their uses in vivo and in vitro in studies on cell functions and cell transplantation. | | 1979 | 37428 |
| inhibitory effects of substantia nigra on impulse transmission from nociceptors. | | 1979 | 37473 |
| the ganglion cell layer of the retina of the rat: a golgi study. | in whole-mounts of golgi stained rat retinae four cell types are described in the ganglion cell layer. three of these cell types are considered to be analogous to the alpha, delta and gamma cells described in the cat retina by boycott & wässle (1974). the fourth cell type is thoughtt to be a displaced amacrine cell. all the cell types described are present in all parts of the retina. there is no evidence for an increase in dendritic field size with increasing distance from the optic disk. | 1979 | 37522 |
| [innervation of the cerebral blood vessels of vertebrates (author's transl)]. | | 1979 | 37689 |
| beta-adrenergic inhibitory interference with myogenic vascular reactivity during experimental intervention. | | 1979 | 37696 |
| pharmacological studies on 3-]gamma-(p-fluorobenzoyl)propyl]-2,3,4,4a,5,6-hexahydro-1-(h)-pyrazino ]1,2-a] quinoline hydrochloride (compound 69/183). part iii: assessment of tranquillising activity. | the tranquillising activity of 3-[gamma-(p-fluorobenzoyl)propyl]-2,3,4,4a,5,6-hexahydro-1-(h)-pyrazino [1, 2-a]quinoline hydrochloride (centpyraquin), a new adrenergic neurone blocking antihypertensive agent, has been evaluated in various laboratory animals. the compound has a calming effect in mice, rats, cats and monkeys. in low doses it reduces the spontaneous motor activity followed in progressively higher doses by hypothermia, ptosis and catalepsy and a taming effect in monkeys and cats. it ... | 1978 | 37855 |
| dendro axonic neurotransmission. ii. morphological sites for the synthesis, binding and release of neurotransmitters in dopaminergic dendrites in the substantia nigra and cholinergic dendrites in the neostriatum. | morphological evidence is presented indicating sites of synthesis, storage, and release of neurotransmitters in dendrites of dopaminergic cells of the substantia nigra and cholinergic cells of the neostriatum. smooth endoplasmic reticulum can be identified in dopaminergic neurons touching the dendritic surface. the false transmitter for dopamine, 5-hydroxydopamine (5-ohda), is localized to smooth endoplasmic reticulum or large vesicular structures which approach the dendritic surface. the dopami ... | 1979 | 37984 |
| determinants of hypoxic contracture in isolated heart muscle preparations. | further studies on hypoxic contracture are described, using resting and contracting isolated muscle preparations from several species. the effect of temperature, ph, substrate, calcium concentration, osmolality and inotropic interventions was explored. the 'protective' effect of acidosis was not contingent on its negative inotropic influence. no evidence was adduced that hypoxic contracture can be modulated other than by altering energy supply or demand. the study does not discriminate between r ... | 1979 | 38007 |
| a qualitative comparison between the pharmacological properties of nictitating membrane-superior cervical ganglion preparations of rabbit and cat. | | 1979 | 38041 |
| [pharmacological activity of n-basic substituted derivatives of 1,3-dimethylxanthine]. | the authors carried out studies on cats, guinea pigs, rats and mice, using isolated smooth muscle organs (bronchi, ileum of guinea pig), and examined bronchodilatating, diuretic, antihistaminic action and acute toxiticy of three n-basic substituted derivatives of 1,3-dimethiylxanthine (theophyline) namely: 7-bis-(2-hydroximethyl)-amino-ethyl theophyline under the form of a base (compound g111, tartarate (g112) and nicotinate (g113). the studies were performed in comparison with theophyline. it w ... | 1979 | 38099 |
| [anxiolytic drugs and inhibition]. | the term "désinhibition" has a different meaning for the psychopharmacologist and for the psychiatrist. the action of anti anxiety agents on animal behavior is described with a special interest for the passive and active avoidance tests. the mode of action and the site of action of benzodiazepines is discussed, focussed on the existence of an endogeneous ligand displacing the binding of diazepam. the differences between low and high doses of anti-anxiety agents are stressed in patients and norma ... | 1978 | 38106 |
| changes in reactivity of visceral resistive and capacitive vessels during adaptation to high mountain conditions. | | 1978 | 38203 |
| analysis of the contractile effect of 5-hydroxytryptamine on the isolated posterior communicating artery of the cat. | 5-hydroxytryptamine (5-ht) induced dose-dependent increases in tension on the isolated posterior communicating artery (pca) of the cat were significantly antagonized by lysergic acid diethylamide (lsd, 6 x 10(-9). in the presence of the phentolamine (10(-6) m) the contraction induced by the two lowest doses of 5-ht was significantly reduced. pretreatment of the animals with reserpine (3 mg kg-1, i.p., total dose) did not modify the dose-response curve to 5-ht except for the lowest dose. removal ... | 1979 | 38315 |
| effects of excitatory and inhibitory amino acids on phasic respiratory neurons. | the responsiveness of phasically active brainstem respiratory neurons to several amino acids was investigated in cats under dial anesthesia. four-barreled microelectrodes were used to extrude iontophoretically the putative neurotransmitters l-glutamate, l-asparatate, glycine, and gamma-aminobutyric acid (gaba), l-glutamate and l-aspartate caused increased activity when applied to either inspiratory or expiratory neurons and appeared to be equal in efficacy. likewise, gaba and glycine depressed o ... | 1979 | 38345 |
| [biochemical effects of psychotropic drugs in central nervous system (author's transl)]. | studies on the biochemical effects of clinically used psychotropic drugs in brain have shown that they all exert their action by a direct or indirect interference with synaptic transmission. thus, animal studies in vivo and in vitro have shown that the clinical efficacy of antipsychotic drugs correlates with their inhibitory action on dopamine receptors. in vivo these compounds enhance dopamine turnover in the brain and in vitro they inhibit the dopamine sensitive adenylate cyclase and the bindi ... | 1979 | 38360 |
| stereopsis and the random element in the organization of the striate cortex. | receptive field position and orientation disparities are both properties of binocularly discharged striate neurons. receptive field position desparities have been used as a key element in the neural theory for binocular depth discrimination. since most striate cells in the cat are binocular, these position disparities require that cells immediately adjacent to one another in the cortex should show a random scatter in their monocular receptive field positions. superimposed on the progressive topo ... | 1979 | 38456 |
| the development of stereoscopic mechanisms in the visual cortex of the cat. | it is argued that those neural systems (such as that responsible for stereoscopic vision) that have the greatest precision of operation are the most likely, during their developmental construction, to take advantage of infromation supplied by their own input. there is evidence that binocularly driven neurons in the kittens's visual cortex do indeed become modified in their synaptic organization during early visual experience in a manner that enhances the specificity of binocular interaction and ... | 1979 | 38460 |
| stereoscopic subsystems for position in depth and for motion in depth. | we describe psychophysical evidence that the human visual system contains information-processing channels for motion in depth in addition to those for position in depth. these motion-in-depth channels include some that are selectively sensitive to the relative velocities of the left and right retinal images. we propose that the visual pathway contains stereoscopic (cyclopean) motion filters that respond to only a narrow range of the directions of motion in depth. turning to the single-neuron lev ... | 1979 | 38461 |
| discriminative stimulus properties of psychomotor stimulants in the cat. | cats were trained to choose between two levels or an operant chamber using interoceptive cues provided by d-amphetamine or saline as the discriminative stimuli. following training, stimulus generalization was observed to additional doses of d-amphetamine and cocaine. but not to morphine. clozapine blocked the generalization of the drug discrimination response to d-amphetamine, but had no effect on generalization to cocaine. these data indicate that discriminative stimulus properties of psychomot ... | 1979 | 38476 |
| analysis of the dissociation between the neocortical and hippocampal eeg activity induced by neuroleptics. | | 1979 | 38477 |
| [morphofunctional features of the substantia nigra, its role in brain pathology and the action of pharmacologic substances]. | | 1979 | 38580 |
| [dynamics of the neurohumoral reactions of the resistive and capacitive vessels of the skin-muscle region in cats in the process of adaptation to the alpine conditions in the tien shan. iii. reactions to the intra-arterial administration of catecholamines]. | | 1979 | 38588 |
| [pharmacology of tianshan adonis]. | | 1979 | 38596 |
| [evolution of neuronal connecting mechanisms: electrical, mixed and chemical synapses]. | investigation of the mechanisms of junctional transmission in the isolated spinal cord in cyclostomes, amphibians, reptilia and mammals reveals the decrease in the number of electrical synapses during evolution from primitive to more advanced vertebrates. electrical transmission is lacking in reptilian and mammalian cord. on the basis of these data, the analysis of the unitary epsps evoked in motoneurons of the lamprey and frog by intracellular stimulation of reticulospinal axons and primary aff ... | 1979 | 38611 |
| pharmacological investigation on the neurohumoral transmission of the vasomotor regulation. | renal efferent sympathetic activity and its changes due to stimulation of the central stump of the vagal, sciatic and ulnar nerves were investigated. in addition, the effect on basal activity and sympathetic reflexes of drugs with well defined site of action was studied (diazepam, tofizopam, phentolamine, dihydroergotamine, chlorpromazine, reserpine, clonidine, atropine, methysergide and phenindamine). the sympathetic efferent activity and the changes in sympathetic reflexes allowed conclusions ... | 1977 | 38630 |
| abstracts of the lectures delivered at the 42nd congress of the hungarian physiological society, budapest, june 10--12, 1976. | | 1978 | 38631 |
| diabetes-induced alterations of autonomic nerve function in the cat. | the susceptibility to competitive ganglionic blocking agents such as hexamethonium (c6), tetraethylammonium bromide (teab), mecamylamine and d-tubocurarine (d-tc), of the superior cervical ganglion in cats with pancreatectomy and spontaneous diabetes or in animals treated with contrainsular drugs such as cortisone or dihydrochlorothiazide, was found to be decreased as compared to the reactivity of normal controls. the increased tolerance to ganglioplegics was not correlated with the elevation of ... | 1978 | 38632 |
| general pharmacology of amitriptylinoxide. | | 1978 | 38803 |
| the mechanism of the clonidine-induced reduction in peripheral parasympathetic submaxillary salivation. | the mechanism of the clonidine induced reduction in submaxillary salivation evoked by electrical stimulation of the chorda tympani was investigated in anaesthetised cats. this effect of clonidine was found to be dose and frequency dependent. in addition to clonidine, tramazoline, also a preferential presynaptic alpha-adrenoceptor agonist, produced a reduction in electricallly evoked salivation. methoxamine, noradrenaline and naphazoline, which are less potent presynaptic alpha-receptor agonists, ... | 1979 | 38975 |
| [comparative characteristics of the effect of noninhalational narcotics on the reflex mechanisms of blood circulation regulation]. | it has been shown in experiments on cats with intact brain, as well as on decerebrated and spinal animals that chloralose, sombrevine and viadril exert no pronounced effect on initial electric activity in the renal nerve or baroreceptor inhibition of the neurogenous vascular tone, but inhibit vasomotor responses at stimulation of highly liminal afferent fibers of the cerebrospinal nerves. in animals with intact brain, sodium hydroxybutyrate inhibiting baroreceptor reflexes enhanced vasomotor rea ... | 1979 | 38996 |
| a comparison of the influence of n-isopropyl and n-tert butyl substituents on the affinity of ligands for sinoatrial beta-adrenoceptors in rat atria and beta-adrenoceptors coupled to the adenylyl cyclase in kitten ventricle. | | 1979 | 39258 |
| effects of cyclobenzaprine on spinal synaptic transmission. | | 1979 | 39270 |
| cardiovascular profile of 2-(3,4-diethyoxy-beta-methoxyphenethyl) imino-1-methylpyrrolidine fumarate (mcn-2840-46), a preferential atrial anti-arrhythmic agent. | mcn-2840-46, 2.5 mg/kg, i.v., protected against atrial tachyarrhythmias induced by three different methods in dogs and monkeys. the compound was inactive against ventricular arrhythmias produced by ouabain and by chloroform-epinephrine interaction at a four-fold higher dose. significant reversal of ventricular arrhythmias produced by occlusion of the left anterior descending coronary artery in dogs was achieved by infusion of 8.8 +/- 2.4 mg/kg, i.v. of mcn-2840-46. myocardial electrogram studies ... | 1979 | 39528 |
| pharmacological properties of 6-(o-chlorophenyl)-8-ethyl-1-methyl-4h-s-triazolo[3,4-c]thieno[2,3-e] [1,4]diazepine (y-7131), a new anti-anxiety drug. | 6-(o-chlorophenyl)-8-ethyl-1-methyl-4h-s-triazolo[3,4-c]thienol[2,3-e][1,4]diazepine (y-7131), a new derivative of the thienodiazepines, had marked activities in antipentylenetetrazole effect in mice, attenuation of conflict behavior in rats, inhibition of aggressive behavior induced by hypothalamic stimulation in cats and muscle relaxant effects in normal and decerebrate cats. y-7131 had weak activities in anti-mes effect in mice and loss of righting reflex in mice. the acute toxicity of y-7131 ... | 1978 | 39570 |
| biochemical properties and kinetic parameters of dihydroxyphenylalanine--5-hydroxytryptophan decarboxylase in brain, liver, and adrenals of cat. | biochemical properties and kinetic parameters of nonpurified dihydroxyphenylalanine-5-hydroxytryptophan decarboxylase extracted from brain and two peripheral organs, liver and adrenals, were studied in the cat. this study shows that decarboxylase activity in brain is lower than in peripheral organs and that 5-hydroxytryptophan can be decarboxylated without exogenous addition of pyridoxal-5'-phosphate (plp). however, the addition of plp substantially increases the enzyme activity. excess of coenz ... | 1979 | 39668 |
| cardiotonic activity of amrinone--win 40680 [5-amino-3,4'-bipyridine-6(1h)-one]. | the cardiotonic activity of a new, noncatechol, nonglycoside agent, amrinone, was investigated in vitro and in anesthestized and unanesthetized dogs. amrinone (3-100 microgram/ml) caused a dose-dependent increase in papillary muscle developed tension and df/dt without significant changes in duration of the contractile cycle or time-to-peak tension. amrinone induced slight increases in right atrial rate with no changes in electrophysiological properties of the cat papillary muscle or dog purkinje ... | 1979 | 39684 |
| comparison of the beta-adrenoceptor effects of soterenol and its 3-hydroxy, 4-sulphonamido isomer (mj6987-1) in isolated tissues from the guninea-pig. | 1. soterenol and its 3-hydroxy, 4-methanesulphonamido isomer (mj6987-1) were compared with isoprenaline for beta-adrenoceptor mediated effects in guinea-pig atrial, tracheal, uterine and ileal preparations. in addition, mj6987-1 was tested for its effects in the atria of cats, rabbits and rats. 2. soterenol had a lower intrinsic activity and was approximately two to six times less active than isoprenaline in all preparations. 3. mj6987-1 was a full agonist, being some 30--200 times less active t ... | 1979 | 39696 |
| fetal respiration: a review of two techniques for observation. | | 1979 | 39701 |
| beta-adrenoreceptors of the posterior hypothalamus. | cats were anaesthetized with pentobarbital sodium. a push-pull cannula was inserted into the posterior hypothalamus which was superfused through the cannula and electrically stimulated with its tip. electrical stimulation elicited a frequency-dependent pressor response and tachycardia. superfusion with orciprenaline, isoprenaline (beta 1- and beta 2-stimulants) or tazolol (beta 1-stimulant) led to a concentration-dependent enhancement in the pressor response. superfusion with terbutaline caused ... | 1978 | 39711 |
| differentiation of drugs acting centrally upon the cardiovascular system by means of sympathetic and vagal responses. | the response pattern of the autonomic nervous system was investigated after central administration (intra-cisternal, vertebral artery) of amphetamine, morphine, fentanyl, dextromoramide and the substance r 28935, chemically related to the neuroleptic agent pimozide. effects on the sympathetic system were measured by recording electrical discharges of fibres of the (preganglionic) major splanchnic nerve in anaesthetized cats; those on the vagal system by recording the heart rate in anaesthetized ... | 1978 | 39714 |
| [neuropharmacological data on the striatum]. | the striatum constitutes the most voluminous basal ganglia in man. it is issued from ganglionic eminences which are very early bound by limbic kernels. if the cortical and reticulo-spinal projections have been first described the existence of anatomical connexions with the limbic system offers a large number of functional possibilities. the knowledge of the distribution of the different chemical substances which are present within this structure as well as the enzymes necessary for their synthes ... | 1979 | 39737 |
| central alpha-adrenoceptors and the states of vigilance: neuropharmacological experiments in cats. | | 1978 | 39850 |
| physical state of tyrosine hydroxylase in the ganglia and nerve endings. | | 1979 | 39876 |
| effects of low electrolyte media on salt loss and hemolysis of mammalian red blood cells. | cation loss and hemolysis of various mammalian red cells suspended in isotonic non-electrolyte media were investigated. sucrose buffered with 10 mm tris-hepes, ph 7.4 was used as the non-permeable non-electrolyte. mammals from which the red cells were derived include the human, guinea pig, rat, rabbit, newborn calf, newborn piglet and pig, all of which contain k as the predominant cation species (hk type) and the dog, cat, sheep and cow, all of which possess na as the predominant cation species ... | 1979 | 39943 |
| on the possible mode of action of serotonin in neurotransmission and brain dysfunction. | criteria necessary to classify a substance as neurotransmitter are used to determine whether disturbances in neurotransmitter function are involved in brain disorders. six rather stringent criteria for a neurotransmitter are satisfied by the biogenic amine 5-hydroxytryptamine (5-ht): 1. the availability of 5-ht within the cns is proved by its synthesis and transport, 2. it is stored within the presynaptic bouton, 3. presynaptic stimulation releases 5-ht, 4. it reacts with receptors of the synapt ... | 1978 | 39972 |
| the effects of dihydrochandonium and other chandonium analogues on neuromuscular and autonomic transmission. | | 1979 | 39992 |
| beta adrenoceptor blocking properties of mk-761. | mk-761 is a new class of compound which has beta adrenoceptor antagonist and vasodilating properties in a single molecule. the compound has in vitro beta adrenoceptor blocking activity in the isolated cat heart papillary muscle and isolated rat atria. unlike propranolol, it did not depress contactile force. intrinsic sympathomimetic activity was not observed in vitro, (isolated cat papillary muscle, isolated atria) but the compound has some intrinsic sympathomimetric activity because it slightly ... | 1979 | 40012 |
| abstracts of papers presented at a meeting of the british microcirculation society. april 6 and 7, 1979, st. george's hospital medical school, london, england. | | 1979 | 40098 |
| abstracts of papers presented at the 9th meeting of the nordic microcirculation group. february 1-4, 1979, geilo, norway. | | 1979 | 40099 |
| abnormalities of neurotransmitter enzymes in huntington's chorea. | the activities of l-glutamate decarboxylase (gad), gaba-transaminase (gaba-t), choline acetyltransferase (cat), and cysteic and cysteinesulfinic acids decarboxylase (cad/csad) in putamen and frontal cortex in both huntington's chorea and normal tissues were measured. the greatest difference between huntington's and normal tissues occurred in putamen, in which the apparent csad activity was reduced by 85%, while no difference was observed in frontal cortex. gad, cad, and cat activities were also ... | 1979 | 40150 |
| influence of neural and humoral beta-adrenoceptor stimulation on dynamic myogenic microvascular reactivity in cat skeletal muscle. | analysis of myogenic microvascular reactivity in terms of its recently described prominent dynamic component was performed before and during graded sympathetic stimulation and catecholamine infusion. phenoxybenzamine and propranolol were used to differentiate between alpha- and beta-adrenoceptor effects. the study first confirmed previous findings of a beta-adrenergic inhibitory component in the neural control of microvascular resistance which attenuated the alpha-adrenergic constriction. the re ... | 1979 | 40397 |
| relationship between calcium and hydrogen ions in heart muscle. | | 1979 | 40437 |
| [cerebral function monitor and responses to stimuli]. | sudden changes in cerebral activity occurring in response to controlled stimuli or resulting from surgery were recorded with the monitor of cerebral function in an appreciable number of cases. the fluctuations in activity that were observed lasted for various lengths of time and consisted mainly of an elevation of the trace associated with cortical excitation. these fluctuations occurred in various different clinical situations such as under general anaesthesia or under er the effect of barbitur ... | 1979 | 40475 |
| effects of some adrenergic blockers on the abstinence syndrome of addicts to drugs and alcohol. | pyrroxand and butyroxan -- original drugs possessing hyghly selective alpha-adreno-blocking action at peripheral and central level-relieve symptoms of abstinence syndrome caused by narcotics and other addicting drugs. on the basis of these data it is suggested that adrenergic structures of the brain play a key role in eliciting the abstinence syndrome. | 1978 | 40502 |
| auditory mechanisms of the lower brainstem. | | 1978 | 40526 |
| improvement of brain tissue oxygenation during cerebrovascular insufficiency by interfering with the catecholaminergic system. | | 1979 | 40543 |
| evidence for two distinct types of postsynaptic alpha-adrenoceptor in vascular smooth muscle in vivo. | 1 the effects of the highly selective alpha(1)-adrenoceptor antagonist, prazosin, and the relatively selective alpha(2)-adrenoceptor antagonist, yohimbine, on the pressor responses to intravenous injections of phenylephrine and noradrenaline have been examined in anaesthetized cats and pithed rats in an attempt to determine whether alpha(1)- and alpha(2)-adrenoceptors are located postsynaptically on vascular smooth muscle.2 in anaesthetized cats prazosin caused a much greater reduction in the pr ... | 1979 | 40647 |
| evidence for a gabaergic projection from the substantia nigra to the ventromedial thalamus and to the superior colliculus of the rat. | unilateral intranigral infusion of kainic acid (1.5 microgram) produced neuronal loss in the lateral two-thirds of the nigra while sparing axons en passage. fink-heimer silver impregnation revealed dense terminal degeneration in the nigra itself (both in the compacta and in the reticulata) and in areas of non-dopaminergic nigral projection such as the ventromedial (vm) nucleus of the thalamus, the superior colliculus and the reticular formation; only spare terminal degeneration was found in area ... | 1979 | 40667 |
| pa2 values of selective beta-adrenoceptor antagonists on isolated atria demonstrate a species difference in the beta-adrenoceptor populations mediating chronotropic responses in cat and guinea-pig. | pa2 values for atenolol (beta 1-selective) and alpha-methylpropranolol (beta 2-selective) have been determined on isolated atria of cat and guinea-pig using noradrenaline (beta 1-selective) and fenoterol (beta 2-selective) as agonists. on guinea-pig atria, the pa2 values did not vary with the agonist used. on cat atria the pa2 for atenolol was greater with noradrenaline than with fenoterol and the pa2 for alpha-methylpropranolol was greater with fenoterol than with noradrenaline. fenoterol was 2 ... | 1979 | 41041 |
| cardiovascular studies with impromidine (sk&f 92676), a new very potent and specific histamine h2-receptor agonist. | impromidine (sk & f 92676) has recently been identified as a potent and specific histamine h2-receptor agonist. the present paper describes some cardiovascular studies with the drug. impromidine lowers blood pressure in cats and rats by interaction with h2-receptors. during continuous intravenous infusions of impromidine, the fall in blood pressure is due to a reduction in total peripheral resistance; cardiac output increases during hypotension. the responses to impromidine are similar to respon ... | 1979 | 41056 |
| haemodynamic effects of the carboxylic ionophore monensin when administered before and during shock induced by e. coli endotoxin. | the haemodynamic effects of the carboxylic ionophore monensin have been examined in cats anaesthetized with sodium pentobarbitone. marked increases in left ventricular dp/dtmax (and dp/dt at fixed isovolumic pressures) and slight increases in cardiac output and stroke volume occurred, indicating increased myocardial contractility. heart rate was unchanged but systemic arterial pressure was substantially increased. satisfactory increases in contractility and arterial pressure were obtained when m ... | 1979 | 41057 |
| non-competitive-non-equilibrium alpha-adrenoceptor blocking properties of n-benzyl iodoacetamide, betsamide. | n-benzyl iodoacetamide, betsamide, at 10 mg kg-1 i.v. blocked the hypertensive and contractile responses of the nictitating membrane of the cat to adrenaline. the blockade had a lag period before full development. pretreatment of cats with betsamide for 7 or 18 h showed a non-equilibrium type of alpha-adrenoceptor blockade. the responses of the nictitating membrane to adrenaline were markedly depressed and did not recover after high doses of adrenaline. in the same cats, adrenaline caused a prof ... | 1979 | 41059 |
| responses of purkinje cells of the cerebellar vermis to neck and macular vestibular inputs. | 1. the dynamic analysis of the control exerted by neck and macular vestibular receptors on the cerebellar cortex has been investigated in precollicular decerebrate cats submitted to sinusoidal rotation along the longitudinal axis of the animal at the frequency of 0.026 hz and at peak amplitudes up to 10 degrees for the neck input and 15 degrees for the macular input. 2. purkinje (p) cells located in the vermal cortex of the cerebellar anterior lobe, particularly in the longitudinal parasagittal ... | 1979 | 41218 |
| modification of cerebrovascular co2 reactivity by inhibition of dopamine beta-hydroxylase. | the influence of sympathetic nervous activity on cerebral circulation and cerebrovascular co2 reactivity was investigated through inhibition of dopamine beta-hydroxylase (dbh). a po2 electrode, a pco2 electrode and a plate-type thermocouple-flowmeter were placed on the pial surface of the cat brain. cerebrocortical po2, pco2, cerebrocortical blood flow and arterial blood pressure were continuously recorded before, during and after intracarotid infusion of 10 mg/kg of fusaric acid, a potent dbh i ... | 1979 | 41344 |
| arterial air embolism in the cat brain. | in cats air embolism of the brain was produced by injecting 0.6 ml blood foam into the innominate artery proximal to the origin of both common carotid arteries. air embolism caused transient ischemia of the brain, reaching a maximum within 1 min after injection. resolution of the air embolism began a few minutes later and was completed within 15 min in the center and within 30 min in the border zone of the main supplying arteries. during this phase tissue perfusion was inhomogenous with reduced ... | 1979 | 41347 |
| gaba and central monoamine release. | | 1978 | 41366 |
| on the classification and distribution of beta-adrenoceptors. | | 1979 | 41395 |
| non-specific myocardial depression by beta-adrenergic receptor blockers in normal and compromised myocardium. | | 1979 | 41496 |
| the resolution of dopamine and beta 1- and beta 2-adrenergic-sensitive adenylate cyclase activities in homogenates of cat cerebellum, hippocampus and cerebral cortex. | the stimulation of adenylate cyclase by dopamine and various beta-adrenergic agonists has been investigated in homogenates from 3 areas of cat brain: the cerebral cortex, cerebellum and hippocampus. the purpose of the study was to determine whether the beta-arenergic receptors coupled to adenylate cyclase could be classified as either beta 1 and beta 2 subtypes in the different regions studied. the stimulation of adenylate cyclase by the beta-adrenergic agonist, (-)isoproterenol (5 x 10(-6) m), ... | 1979 | 41616 |
| a review of feline viral rhinotracheitis (feline herpesvirus i infection). | | 1979 | 41670 |
| aortic body chemoreceptor responses to changes in pco2 and po2 in the cat. | responses of aortic chemoreceptor afferents to a range of arterial carbon dioxide tension (paco2) changes at various levels of arterial oxygen tension (pao2) were investigated in 18 cats anesthetized with alpha-chloralose and maintained at 38 degrees c. aortic chemoreceptor activity, end-tidal oxygen pressure, end-tidal carbon dioxide pressure, and arterial blood pressure were continuously monitored. arterial blood gases were measured in steady states. single or a few clearly identifiable affere ... | 1979 | 41829 |
| metabolic control of neuronal pacemaker activity and the rhythmic organization of central nervous functions. | the endogenous rhythmic activity of isolated pacemaker neurones of aplysia californica appears to be controlled by the operation of a substrate cycle. the recycling of fructose-6-phosphate is mediated by two membrane-bound enzymes: phosphofructokinase (pfk) and fructose-1,6-diphosphatase (fdpase). allosteric effectors which promote the pfk-fdpase system either increase the regular beating activity or induce bursting discharges, while inhibitory effectors reduce pacemaker activity. associated wit ... | 1979 | 41878 |
| nuciferine and central glutamate receptors. | | 1979 | 41920 |
| high efficiency coupling between beta-adrenergic receptors and cardiac contractility: direct evidence for "spare" beta-adrenergic receptors. | | 1979 | 42013 |