| prenatal exposure, maternal sensitization, and sensitization in utero to indoor allergens in an inner-city cohort. | primary sensitization to antigens may occur prenatally. we hypothesized that high prenatal exposure to indoor antigens increases the risk for sensitization in newborns in new york city populations with increased risk for asthma. we also investigated whether maternal sensitization is required for in utero sensitization to occur. one hundred sixty-seven pregnant african american or dominican women residing in northern manhattan were recruited and antigen was measured from home dust. after delivery ... | 2001 | 11587985 |
| respiratory symptoms in relation to indoor exposure to mite and cat allergens and endotoxins. indoor factors and genetics in asthma (inga) study group. | the authors investigated the relationship between respiratory symptoms in adults and exposure to mite and cat allergens, the role of endotoxins in house dust, the effects of mixtures of several allergens, and interactions between allergen exposure and allergic sensitization. within a nested case-control study, 405 subjects aged 25-50 yrs from two german cities answered a standardized questionnaire. allergen-specific immunoglobulin-e was measured. dust samples were taken from the subjects' homes ... | 2001 | 11589355 |
| ige binding components in tetranychus urticae and panonychus ulmi-derived crude extracts and their cross-reactivity with domestic mites. | recent investigation has revealed that spider mites such as tetranychus urticae and panonychus ulmi are important allergens in the development of occupational asthma among apple farmers. | 2001 | 11591197 |
| a genomewide search for quantitative-trait loci underlying asthma. | a genomewide screen for quantitative-trait loci (qtls) that underlie asthma was performed on 533 chinese families with asthma, by the unified haseman-elston method. nine asthma-related phenotypes were studied, including forced expiratory volume in 1 s (fev1), forced vital capacity (fvc), airway responsiveness as indicated by methacholine (mtch)-challenge test, serum total immunoglobulin e (tige), serum-specific immunoglobulin e, eosinophil count in peripheral blood, and skin-prick tests with thr ... | 2001 | 11673820 |
| a prospective study of the association between home gas appliance use during infancy and subsequent dust mite sensitization and lung function in childhood. | home gas appliance use has been associated with child respiratory illness but prospective data on the relationship between infant exposure and the development of child allergic disease has not been readily available. | 2001 | 11678854 |
| evaluation of the acarofauna of the domiciliary ecosystem in juiz de fora, state of minas gerais, brazil. | from august 1999 to january 2000, samples of house dust were collected from 160 domiciles in the city of juiz de fora, state of minas gerais, brazil. in 36 of these domiciles kitchen samples were obtained. prevalence rate was 77.5%, varying according to the geographical sector. there were found 2,278 specimens of mites, with 1,530 (67.2%) in the adult stage and 748 (32.8%) in immature forms. the main species found were dermatophagoides pteronyssinus, d. farinae, euroglyphus maynei, blomia tropic ... | 2001 | 11685254 |
| the effects of ma-xing-gan-shi-tang on respiratory resistance and airway leukocyte infiltration in asthmatic guinea pigs. | ma-xing-gan-shi-tang (mxgst), a traditional chinese medicine, has been used in treatment of the bronchial asthma for several centuries. however, the therapeutic mechanisms of this chinese medicine are still far from clear. to understand the mechanism of anti-asthmatic property of mxgst, a guinea pig model of allergic asthma was used to investigate the effects of mxgst on dermatophagoides pteronyssinus-induced early and late asthmatic responses and airway inflammation, and examine direct beta2-ad ... | 2001 | 11694034 |
| independent effects of intestinal parasite infection and domestic allergen exposure on risk of wheeze in ethiopia: a nested case-control study. | why asthma is rare in rural subsistence societies is not clear. we tested the hypotheses that the risk of asthma is reduced by intestinal parasites or hepatitis a infection, and increased by exposure to dust-mite allergen or organophosphorus insecticides in urban and rural areas of jimma, ethiopia. | 2001 | 11705561 |
| oral tolerance induction in dermatophagoides pteronyssinus-sensitized mice induces inhibition of ige response and upregulation of tgf-beta secretion. | oral antigen administration induces peripheral tolerance in naive animals. studies of oral tolerance induction in sensitized mice have clinical relevance as a strategy to modulate allergy. in this study, the a/sn mice sensitized with extract of dermatophagoides pteronyssinus (dp) and submitted to oral dp administration showed a marked decrease in ige anti-dp antibody production compared with sensitized phosphate-buffered saline (pbs)-fed mice. t cells from dp-fed mice cocultured with spleen cell ... | 2001 | 11710995 |
| exhaled nitric oxide in asthmatic and non-asthmatic children: influence of type of allergen sensitization and exposure to tobacco smoke. | asthmatic bronchial inflammation is associated with increased nitric oxide concentrations in exhaled air (eno). recent data suggest that this effect arises from atopy. our aim in this study was to find out whether atopy and sensitization to particular allergens influences eno levels. a total of 213 subjects (41 asthmatics and 172 controls) (96 boys and 117 girls, 7.3-14 years of age) were studied. parents completed a questionnaire that sought information on their children's respiratory symptoms ... | 2001 | 11737671 |
| safety evaluation of a glutaraldehyde modified tyrosine adsorbed housedust mite extract containing monophosphoryl lipid a (mpl) adjuvant: a new allergy vaccine for dust mite allergy. | a new allergy vaccine is currently under clinical evaluation for the prevention or relief of symptoms caused by specific housedust mites. it consists of a 50:50 mixture of the mite dermatophagoides pteronyssinus and d. farinae protein derived from aqueous extracts of the mites which is chemically modified by glutaraldehyde and adsorbed onto l-tyrosine with addition of the immunostimulatory adjuvant, monophosphoryl lipid a (mpl) "polymite". a specific preclinical safety testing strategy was devel ... | 2001 | 11738737 |
| the role of cd28-b7 costimulation in allergen-induced cytokine release by bronchial mucosa from patients with moderately severe asthma. | t cells play an important role in airway inflammation in asthma through the release of t(h)2 cytokines. optimal t-cell activation by antigen-presenting cells requires co-stimulatory signaling, such as the interaction of cd80, cd86, or both with cd28. in patients with mild allergic asthma, the fusion protein cytotoxic t-lymphocyte antigen 4ig (ctla-4ig), which inhibits cd28-mediated signaling, blocks the release of il-5 and il-13 from bronchial explant cultures exposed to the allergen dermatophag ... | 2001 | 11742276 |
| atopy, allergic diseases and work-related symptoms among students of agricultural schools: first results of the lublin study. | 136 eastern-polish farming students (51 females and 85 males, aged 16-23 years) underwent clinical examination, skin prick tests with common and farm-specific allergens, total ige measurement and phadiatop test. atopy was found in 35.3% (95% ci: 27.3-43.3%) of students. for allergic skin diseases, the point prevalence was 5.9%, the lifetime prevalence 28.7%; for allergic rhinitis 12.7% and 16.4%; for asthma 2.2% and 8.8% respectively. 56 students (41.2%) complained of work-related symptoms; most ... | 2001 | 11748886 |
| peripheral blood mononuclear cell responses to major and minor dermatophagoides allergens in canine atopic dermatitis. | atopic dermatitis is a chronic inflammatory and pruritic skin disease commonly seen in dogs and humans. most cases involve hypersensitivity to the house dust mites (hdm) dermatophagoides farinae and dermatophagoides pteronyssinus. human atopic dermatitis is associated with the hdm derived allergens der f 1 and 2, and der p 1 and 2. serological data, however, suggest that a 98/104kd protein is the most important allergen in dogs with atopic dermatitis. the aim of this study was to characterise th ... | 2002 | 11777530 |
| [induction of atopic dermatitis-like skin lesion in nc/nga mice--the influence of the skin barrier destroying solution to the induction of dermatitis]. | nc/nga mouse is well known as a mouse model for atopic dermatitis. in general, when nc/nga mouse are raised under specific pathogen free (spf) conditions no skin lesions are detected, but when under non-filtrated (conventional) condition, atopic dermatitis like skin lesions appear spontaneously. however, this dermatitis develops in 70-90% of mice (not 100%), which makes it difficult to perform reproducible experiments every time. this study was performed under spf conditions, using the four solu ... | 2001 | 11830999 |
| levels of house dust mite-specific ige and cockroach-specific ige and their association with lower pulmonary function in taiwanese children. | sensitization to an aeroallergen is known to diminish pulmonary function in young children and adults; however, it remains unclear whether it produces similar effects in adolescents. this study, therefore, examined the relationship between serum allergen-specific ige levels and pulmonary function in adolescents. | 2002 | 11834642 |
| [respiratory allergy to house dust: dermatophagoides pteronyssinus versus dermatophagoides farinae] ]. | house dust is one of the most common allergens that cause allergic respiratory diseases. it is a composed allergen, although the most important antigens are the mites dermatophagoides pteronyssinus (der p) and dermatophagoides farinae (der f). these mites have different geographic and climatic distribution. the aim of the study was to determine the sensitisation to der p and der f in our population of patients with respiratory allergic disorders. the investigation included 93 patients with peren ... | 2001 | 11845577 |
| allergic sensitisation to common environmental allergens in adult asthmatics in hong kong. | the relationship between immediate skin reactivity to common allergens and adult asthma is not well defined. we retrospectively evaluated the profile of allergen sensitisation to common environmental allergens in 666 adult asthma patients at an asthma clinic in a teaching hospital in hong kong. four hundred and seventy-one asthmatics (70.7%) were atopic; there were more males than females, although the difference did not reach statistical significance. the skin test positively rate decreased sig ... | 1997 | 11850573 |
| positive association between hla-drb1*07 and specific ige responses to purified major allergens of d. pteronyssinus (der p 1 and der p 2). | human leukocyte antigen (hla) class ii gene products are involved in the antigen presentation of exogenous antigens. the aim of this study was to evaluate whether specific immunoglobulin (ig)e responses to purified major allergens of dermatophagoides pteronyssinus (der p 1 and der p 2) were associated with genotypes of hla-drb1 alleles. | 2002 | 11868921 |
| individual allergens as risk factors for asthma and bronchial hyperresponsiveness in chinese children. | the role of allergen sensitization in the development of asthma in the chinese is not clear. this study aims to determine the relationship of sensitization to individual allergens, and the development of asthma and bronchial hyperresponsiveness (bhr) in schoolchildren from three chinese cities: hong kong, beijing and guangzhou. community-based random samples of 10-yr-old schoolchildren from three chinese cities were recruited for study using the international study of asthma and allergies in chi ... | 2002 | 11871366 |
| expression and characterisation of a psoroptes ovis glutathione s-transferase. | the astigmatid mite psoroptes ovis is the causative agent of sheep scab, a highly contagious parasitic disease of sheep. infection causes severe allergic dermatitis, resulting in damage to the fleece and hide, loss of condition and occasional mortality. interest in the p. ovis allergens led us to characterise a glutathione s-transferase (gst) which displays homology to gst allergens isolated from the house dust mite, dermatophagoides pteronyssinus and the cockroach, blatella germanica. a cdna en ... | 2002 | 11879966 |
| the clinical efficacy of in vitro allergen-specific ige antibody test in the diagnosis of allergic children with asthma. | asthma is a very common respiratory allergic disease in taiwan. the aims of this study were to investigate the allergen-sensitized profile and its relationship with serum total ige levels in allergic asthmatic children in taiwan. moreover, the number of allergens to be tested for the most efficient and effective diagnosis of allergic diseases was also examined. total ige and ige specific for a panel of common aeroallergens were assayed in 200 serum samples of asthmatic children using pharmacia c ... | 2002 | 11890224 |
| prevalence of allergen-specific ige among patients with chronic fatigue syndrome. | the prevalence of atopy among patients having chronic fatigue syndrome (cfs) has been reported to be as high as 80% in published surveys of patients with this syndrome. however, many of the reports relied on self-assessment by patients for the presence of atopy or solely used total immunoglobulin e (ige) levels to assess the likelihood of atopy. to more critically assess the presence of atopy among patients with cfs, testing was done for total ige and allergen-specific ige using the pharmacia ca ... | 2002 | 11894732 |
| sensitivity patterns to house dust mites and forage mites in atopic dogs: 150 cases. | this study investigated intradermal test reactions to extracts of six species of mites in 150 dogs with atopic dermatitis. at least one positive reaction was seen in 120 animals (80%). dermatophagoides farinae attracted the highest number of positive reactions (108 dogs, 90% of dogs and 72% of atopic dogs showing positive reactions). positive reactions to other mites were not uncommon, with many dogs testing positive for dermatophagoides pteronyssinus (32% of dogs tested), acarus siro (35%), tyr ... | 2002 | 11896969 |
| house dust mite allergen exerts no direct proinflammatory effects on human keratinocytes. | dermatophagoides pteronyssinus is a trigger of atopic dermatitis. many d pteronyssinus allergens are proteases that can elicit airway inflammation by stimulating the release of cytokines and chemokines by bronchial epithelial cells. | 2002 | 11898003 |
| influence of maternal murine immunization with dermatophagoides pteronyssinus extract on the type i hypersensitivity response in offspring. | maternal exposure to environmental ubiquitous allergens could exert an influence on the newborn's immune repertoire and the later development of allergy. the aim of this study was to investigate the effects of maternal immunization with dermatophagoides pteronyssinus (dp) on the hypersensitivity response and igg subclass production in offspring using a murine model. | 2002 | 11979046 |
| pattern of sensitization to common environmental allergens amongst atopic singapore children in the first 3 years of life. | this study was aimed to investigate the sensitization pattern to a range of common allergens in young singaporean children. a cross-sectional study involving 75 children aged below 3 years was carried out. they presented between december 1995 and april 2000 with symptoms of asthma, rhinitis, eczema, or food allergy. their levels of allergen-specific serum ige to a panel of foods (egg white, milk, soy protein, shrimp, wheat and peanut), pet dander, dust mites and cockroaches were measured with ph ... | 2001 | 12009071 |
| rate of patch test reactions to a dermatophagoides mix currently on the market: a mite too sensitive? | there long has been debate over the role of the dust mite antigen dermatophagoides in provoking or perpetuating atopic and other forms of dermatitis, particularly airborne contact dermatitis. reactivity to dermatophagoides has been measured by specific ige and by immediate-type responses to prick test challenge. more recently, patch testing has been advocated as a means of determining reactivity to dermatophagoides. | 2002 | 12022123 |
| the impact of in vivo calmette-guérin bacillus administration on in vitro ige secretion in atopic children. | to investigate whether a preexisting t helper (t(h)) 2 type immune response could be suppressed by calmette-guérin bacillus (bcg) immunization in atopic children with asthma, we determined interferon (ifn)-gamma, interleukin (il)-2, il-4, and il-5 and total ige level in the supernatant of peripheral blood mononuclear cells (pbmc) of six atopic and five nonatopic children in response to phytohemagglutinin a (pha), purified protein derivate (ppd), and dermatophagoides pteronyssinus ii allergen (de ... | 2002 | 12043855 |
| distribution variations of multi allergens at asthmatic children's homes. | increasing asthma prevalence is evident in many countries and childhood asthma has also become one of the most common chronic diseases in children. exposure to indoor allergens has been be attributed to a significant increase in asthma occurrence. meanwhile, allergen distribution varies widely among different countries. this brief investigation reports the distribution of common indoor allergens, such as mite (dermatophagoides pteronyssinus, der p 1 and der p 2), cat (felis domesticus, fel d 1), ... | 2002 | 12049401 |
| isolation and characterisation of a 13.8-kda bacteriolytic enzyme from house dust mite extracts: homology with prokaryotic proteins suggests that the enzyme could be bacterially derived. | bacteriolytic activity was detected in extracts of whole mite and spent growth medium (sgm) from the clinically important dermatophagoides pteronyssinus and dermatophagoides farinae mites and was most abundant in whole mite extract. gram-positive organisms micrococcus lysodeikticus, bacillus megaterium and listeria monocytogenes were preferentially lysed and the lytic activity was enhanced by thiols, destroyed by mite proteases, inhibited by hgcl2 and high concentrations of nacl but was resistan ... | 2002 | 12052562 |
| feather bedding and house dust mite sensitization and airway disease in childhood. | feather bedding has been inversely associated with child wheeze and also with house dust mite (hdm) allergen levels. we conducted a cross-sectional analysis of the childhood component of a birth cohort study. our aim was to examine the relation between feather bedding and hdm sensitization and airway disease. a total of 498 children (84% of eligible) residing in northern tasmania in 1997 who were eligible for the tasmanian infant health survey at birth in 1988 or 1989 participated. outcome measu ... | 2002 | 12063097 |
| increase in the prevalence of allergen skin sensitization in successive birth cohorts. | little is known about longitudinal trends in the prevalence of allergen skin sensitization in the general population. | 2002 | 12063526 |
| some immunological aspects of patients with rhinitis in lebanon. | hitherto immunological determinates in lebanese patients with rhinitis have not been investigated. | 2002 | 12066854 |
| cooperative effects of th2 cytokines and allergen on normal and asthmatic bronchial epithelial cells. | in sensitized individuals, exposure to allergens such as dermatophagoides pteronyssinus (der p) causes th2 polarization and release of cytokines, including il-4 and il-13. because der p extracts also have direct effects on epithelial cells, we hypothesized that allergen augments the effects of th2 cytokines by promoting mediator release from the bronchial epithelium in allergic asthma. to test our hypothesis, primary bronchial epithelial cultures were grown from bronchial brushings of normal and ... | 2002 | 12077271 |
| quantitative measurement of serum allergen-specific ige on protein chip. | type i allergy is an immunoglobulin e (ige)-mediated hypersensitivity disease inflicting more than quarter of the world population. in order to identify allergen sources, skin provocation test and ige serology was performed using allergen extracts. such process identifies allergen-containing sources but cannot identify the disease-eliciting allergenic molecules. recently, microarray technology has been developed for allergen-specific ige detection using rolling circle amplification. this study w ... | 2002 | 12085991 |
| effects of laundry detergents on dermatophagoides farinae, dermatophagoides pteronyssinus, and euroglyphus maynei. | house-dust mites in clothing and bedding are the source of major allergens. based on studies of dermatophagoides pteronyssinus only, weekly washing in hot water is recommended to kill dust mites and remove allergens from clothing and bedding. however, in the united states, washing is most often done in warm or cold water, and other mite species are involved. | 2002 | 12086365 |
| therapeutic effect of bacillus calmette-guerin with allergen on human allergic asthmatic patients. | epidemiological studies have suggested that either environmental exposure or immunization with mycobacterium bovis-bacillus calmette-guerin provides protection against atopy and asthma in japanese school children. tuberculin skin tests and tests of airway hyperresponsiveness were performed in asthmatic patients in the course of investigating the effect of bacillus calmette-guerin and dermatophagoides pteronyssinus immunotherapy. a total of 16 asthmatics and 20 normal individuals were recruited i ... | 2002 | 12099343 |
| der p 2 isoallergens have different allergenicity, and quantification with 2-site elisa using monoclonal antibodies is influenced by the isoallergens. | der p 2 isoallergens have been reported and the possibility of different allergenicity has also been suggested. in addition, the quantification with 2-site elisa may be affected by the isoallergens. | 2002 | 12100051 |
| relationship between sensitization to citrus red mite (panonychus citri) and the prevalence of atopic diseases in adolescents living near citrus orchards. | recent investigations have demonstrated that the citrus red mite (panonychus citri, crm) is the most important allergen in citrus fruit farmers with asthma and rhinitis and a common sensitizing allergen in children living near citrus orchards. | 2002 | 12100053 |
| acaricidal activity of butylidenephthalide identified in cnidium officinale rhizome against dermatophagoides farinae and dermatophagoides pteronyssinus (acari: pyroglyphidae). | the acaricidal activity of materials derived from the rhizome of cnidium officinale against adults of dermatophagoides farinae and dermatophagoides pteronyssinus was examined using direct contact application and fumigation methods and compared with that of benzyl benzoate and n,n-diethyl-m-toluamide (deet). the active constituent of the cnidium rhizome was identified as butylidenephthalide by spectroscopic analyses. responses varied with dose. on the basis of 24-h ld(50) values, the acaricidal a ... | 2002 | 12137464 |
| reactivity of anti-blomia tropicalis igg and ige in patients with atopic dermatitis. | patients with atopic dermatitis (ad) commonly develop antibodies of subclasses igg and ige to house dust mites, such as dermatophagoides pteronyssinus and d. farinae. the domestic mite blomia tropicalis is prevalent in brazil and can cause the exacerbation of ad. the objectives of this study were to assess skin reactivity to b. tropicalis extracts of ad patients and a control group of nonallergic subjects, and to determine the in vitro reactivity of anti-b. tropicalis igg and ige in the serum of ... | 2002 | 12139678 |
| identification of shared and unique immunoglobulin e epitopes of the highly conserved tropomyosins in blomia tropicalis and dermatophagoides pteronyssinus. | tropomyosin belongs to a class of highly conserved proteins in invertebrates and vertebrates. the invertebrate tropomyosins are allergenic in man with high ige cross-reactivity and have been therefore referred to as pan-allergens. | 2002 | 12190660 |
| sensitisation to airborne moulds and severity of asthma: cross sectional study from european community respiratory health survey. | to assess whether the severity of asthma is associated with sensitisation to airborne moulds rather than to other seasonal or perennial allergens. | 2002 | 12193354 |
| the dermatophagoides pteronyssinus group 2 allergen contains a universally immunogenic t cell epitope. | the use of t cell epitope-containing peptides for the induction of anergy in allergen sensitization is limited by genetic restriction that could be circumvented by using universally immunogenic epitopes. we attempted to identify such epitopes on dermatophagoides pteronyssinus group 2 allergen (der p 2), a major allergen of d. pteronyssinus t cells from balb/c (h-2(d)), c57bl/6 (h-2(b)), c3h (h-2(k)), and sjl (h-2(s)) mice that were immunized with rder p 2, recognized an immunodominant region enc ... | 2002 | 12193711 |
| association between skin test diagnosed atopy and professionally diagnosed depression: a northern finland 1966 birth cohort study. | several studies have suggested an association between ige-mediated atopic allergies and depression, although thus far no epidemiologic evidence involving a large, unselected, general-population sample and valid methods in diagnosing atopy support this putative association. | 2002 | 12208642 |
| evaluation of the usefulness of sensitization to aeroallergens as a model for canine atopic dermatitis in genetically predisposed beagles. | to evaluate a model for atopic dermatitis (ad) and to measure the effect of sensitization in beagles genetically predisposed to produce high serum concentrations of allergen specific ige. | 2002 | 12224870 |
| determination of antigenic proteins of housedust mites in 90 dogs suffering from atopic dermatitis. | housedust mites, dermatophagoides pteronyssinus (d. pteronyssinus) and dermatophagoides farinae (d. farinae), are the important causative agents of allergic diseases in human and animals. by using 165 dogs suffering from atopic dermatitis (ad), serum levels of immunogloblin e (ige) antibody against 25 kinds of allergen including housedust mites were determined. housedust mites were the most frequent allergen against which 90 of the 165 allergic dogs (54.5%) by immunodot assay. with the further a ... | 2002 | 12237510 |
| house dust mite allergen levels in university student accommodation in dunedin. | to quantify the levels of dermatophagoides pteronyssinus (der p1) in different university student accommodation in dunedin, and to assess relationships with housing characteristics and housekeeping practices. | 2002 | 12362193 |
| atopic allergy and delayed type hypersensitivity in estonian children. | a shift in the balance oft helper (th) cell subsets towards a polarized th2 population is generally accepted to occur in atopic disease, however, both th1 and th2 disorders have increased over the past decades in western communities. | 2002 | 12372119 |
| lactic acid bacteria inhibit th2 cytokine production by mononuclear cells from allergic patients. | among factors potentially involved in the increased prevalence of allergic diseases, modification of the intestinal bacteria flora or lack of bacterial stimulation during childhood has been proposed. lactic acid bacteria (lab) present in fermented foods or belonging to the natural intestinal microflora were shown to exert beneficial effects on human health. recent reports have indicated their capacity to reduce allergic symptoms. | 2002 | 12373271 |
| [behavior of serum ige and iga in patients with allergic rhinitis treated with iodine bromide thermal water]. | the aim of this study was to test the effects of the iodine bromide water of the thermal baths of salsomaggiore on patients suffering from specific nonseasonal rhinitis (dermatophagoides farinae and dermatophagoides pteronyssinus). the patients, 80 in all, were divided in two groups (group a and group b). all of the patients underwent rhinoscopic examination, anterior rhinomanometry, prick test, rast screening, total ige assay together with that of the other immunoglobulins (iga, igm, igg), muco ... | 2002 | 12379042 |
| prevention of der p2-induced allergic airway inflammation by mycobacterium-bacillus calmette guerin. | epidemiologic studies suggest an inverse correlation between infection and development of allergy. the purpose of this study was to test the hypothesis whether a preexisting t helper 1 (th1)-type immune response elicited by mycobacterium bovis-bacillus calmette-guerin (bcg) immunization could suppress allergic airway inflammation induced by the mite allergen dermatophagoides pteronyssinus group 2 (der p2) in an animal model. c57bl/6 mice were immunized with subcutaneous injection of bcg, then in ... | 2002 | 12380787 |
| skin prick test reactivity to common aeroallergens in asthmatic patients with and without rhinitis. | the aim of this study was to investigate the prevalence of skin prick test (spt) reactivity to common aeroallergens among malaysian asthmatic patients with and without rhinitis. | 2002 | 12421243 |
| sputum eosinophilia and maximal airway narrowing in dermatophagoides pteronyssinus allergic rhinitis patients: only rhinitis or rhinitis plus mild asthma? | to study the existence of bronchial disease among rhinitis patients. to evaluate the laboratory test or set of tests (ie, symptoms, exposure, and sensitization to the allergen, and the provocative dose of methacholine [mth] causing a 20% fall in fev(1) [pd(20)] and the maximal response plateau [mrp] to mth) that best identifies a case of mild asthma. | 2002 | 12426253 |
| skin-prick test findings in atopic asthmatic children: a follow-up study from childhood to puberty. | in a prospective cohort study we investigated the course of allergic sensitization from childhood to puberty in a group of children with atopic asthma. an attempt was made to correlate the findings with the persistence of asthma. a total of 150 children with atopic asthma established at 7 years of age were evaluated when 8-10 years of age. a battery of skin-prick tests (spts) to common environmental allergens, a detailed clinical history for asthma severity classification, and spirometric analys ... | 2002 | 12431197 |
| association between mite allergen (der p 1, der f 1, blo t 5) levels and microscopic identification of mites or skin prick test results in asthmatic subjects. | mite allergens have been involved in airway sensitization and allergic diseases. immunoassays for the identification and quantifiction of house dust mite (hdm) allergens are useful to improve the knowledge of regional mite fauna and the remediation of mite allergens in allergic diseases. the present study analyzed the association between levels of hdm allergen and results of mite identification or skin prick test (spt) in two different areas of bahia, brazil. | 2002 | 12444321 |
| the 3 mm skin prick test (spt) threshold criterion is not reliable for tyrophagus putrescentiae: the re-evaluation of spt criterion to dust mites. | the mean wheal diameter >/= 3 mm is the usual criterion for positive skin prick test (spt) reaction to dust mites. the study assessed the accuracy of this spt criterion with respect to specific ige values of above 0.35 kua/l (+ sige). | 2002 | 12464048 |
| differential roles of il-16 and cd28/b7 costimulation in the generation of t-lymphocyte chemotactic activity in the bronchial mucosa of mild and moderate asthmatic individuals. | il-16 is an important t-cell chemotactic cytokine in asthmatic airways; its release from allergen-stimulated bronchial mucosa in mild asthma has been shown to be dependent on cd28/b7 costimulation. | 2002 | 12464958 |
| der p 1-pulsed myeloid and plasmacytoid dendritic cells from house dust mite-sensitized allergic patients dysregulate the t cell response. | although reports suggest that dendritic cells (dc) are involved in the allergic reaction characterized by a t helper cell type 2 (th2) profile, the role of myeloid (m-dc) and plasmacytoid dc (p-dc), controlling the balance th1/th2, remains unknown. here, we showed that in dermatophagoides pteronyssinus (dpt)-sensitized allergic patients and in healthy donors, m-dc displayed a higher capacity to capture der p 1, a major allergen of dpt, than did p-dc. however, der p 1-pulsed m-dc from healthy sub ... | 2003 | 12525566 |
| in vivo and in vitro sensitization to domestic mites in german urban and rural allergic patients. | sensitization to domestic mites is common in germany. the main objectives of this study were (1) to establish the rate of skin test sensitivity to dermatophagoides pteronyssinus, acarus siro, lepidoglyphus destructor, and tyrophagus putrescentiae in 512 consecutive patients evaluated for upper and/or lower respiratory complaints; (2) to verify how many of the patients with a positive skin test to at least one of the three storage mites were also skin test positive to d. pteronyssinus; and (3) to ... | 2002 | 12530116 |
| cloning and expression of blo t 1, a novel allergen from the dust mite blomia tropicalis, homologous to cysteine proteases. | house dust mite allergens have been shown to be a very important stimulus in the causation of asthma and triggers for the exacerbation of symptoms. therefore, characterization of mite-derived allergens at the molecular level is an important step for the development of effective diagnostic and therapeutic approaches, as well as for epidemiological studies. | 2003 | 12534546 |
| studies on house dust mites in great cairo, egypt. | nowadays, house dust mites have showed themselves as one of the health problem worldwide. they have to be considered in the differential diagnosis of allergy particularly in children. house dust mites were collected from eight different areas in great cairo. nine species of mites were recovered from indoors. in order of abundance, they were dermatophagoides pteronyssinus, d. farinae, tyrophagous putrescentiae, acarus siro, cheyletus malaccensis, blomia kulagini, acheles graciles, ornithonyssus b ... | 1999 | 12561892 |
| acaricidal activity of clove bud oil compounds against dermatophagoides farinae and dermatophagoides pteronyssinus (acari: pyroglyphidae). | the acaricidal activity of clove (eugenia caryophyllata) bud oil-derived eugenol and its congeners (acetyleugenol, isoeugenol, and methyleugenol) against adults of dermatophagoides farinae and dermatophagoides pteronyssinus was examined using direct contact application and fumigation methods and compared with those of benzyl benzoate and n,n-diethyl-m-toluamide (deet). responses varied according to compound, dose, and mite species. on the basis of ld(50) values, the compound most toxic to d. far ... | 2003 | 12568544 |
| oral tolerance induction to dermatophagoides pteronyssinus and blomia tropicalis in sensitized mice: occurrence of natural autoantibodies to immunoglobulin e. | the dust mites dermatophagoides pteronyssinus (dp) and blomia tropicalis (bt) are important sources of indoor allergens in tropical and subtropical countries. murine models allow the analysis of the immune response and regulation of ige production to dp and bt allergens. oral tolerance induces unresponsiveness in naive animals, but its application in sensitized animals can provide useful information to improve allergy therapy. | 2002 | 12569990 |
| skin test reactivity to natural and recombinant blomia and dermatophagoides spp. allergens among mite allergic patients in the uk. | many asthmatics in tropical and subtropical areas have positive skin prick tests to both dermatophagoides spp. and to the mite blomia tropicalis. this may be due to recognition by ige of cross-reactive allergens between the different mite species or because of sensitization to species-specific allergens. a 14-kda blomia tropicalis allergen, blo t 5, has been cloned and shows 40% sequence homology with der p 5. the aim of this study was to investigate reactivity to b. tropicalis in patients known ... | 2003 | 12580807 |
| effect of bcg vaccination on cytokine mrna expression in atopic children with asthma. | to investigate whether a preexisting t(h2)-type immune response could be suppressed by bcg immunization in atopic children with asthma. | 2003 | 12600742 |
| specific ige to 5 different major house dust mites among asthmatic children. | asthma is one of the most commonly occurring manifestation of allergy in taiwan. sensitivity to house dust mites is closely related to childhood asthma. this study was designed to investigate sensitized rates and average concentrations of specific ige antibodies to 5 major house dust mites (hdms) among asthmatic children. a total of 93 asthmatic children aged from 3 to 15 years were enrolled to measure their specific ige concentrations in response to 5 different species of mites: dermatophagoide ... | 2002 | 12607482 |
| limpet anaphylaxis: cross-reactivity between limpet and house-dust mite dermatophagoides pteronyssinus. | limpet is a mollusc that is frequently found along the shores of warm seas. few allergic reactions to limpet have been described, and cross-reactivity with house-dust mites has not been established. | 2003 | 12622746 |
| atopy patch tests in young adult patients with atopic dermatitis and controls: dose-response relationship, objective reading, reproducibility and clinical interpretation. | the clinical interpretation and reproducibility of atopy patch tests was studied in 23 selected young adult patients with atopic dermatitis and 25 healthy controls using standard inhalant allergens. non-invasive measurements were used for objective assessment of test reactions and the participants were retested after 6 weeks. ten of 19 (53%) evaluable patients with atopic dermatitis had at least one positive atopy patch test. however, there was no clear clinical relevance of the atopy patch test ... | 2003 | 12636017 |
| an extensive study of human ige cross-reactivity of blo t 5 and der p 5. | dual sensitization by blomia tropicalis and dermatophagoides pteronyssinus mites is common in tropical and subtropical countries. the human ige cross-reactivity between clinical important group 5 allergens, blo t 5 and der p 5, remains controversial. | 2003 | 12642844 |
| intranasal application of chitin microparticles down-regulates symptoms of allergic hypersensitivity to dermatophagoides pteronyssinus and aspergillus fumigatus in murine models of allergy. | previous studies have demonstrated that chitin in the form of microparticles that can be phagocytosed is a potent macrophage stimulator and promotes a th1 cytokine response and it has been shown that oral administration of chitin microparticles is effective in down-regulating serum ige and lung eosinophilia in a mouse model of ragweed allergy. to date there have been no studies on the effectivness of directly applying chitin microparticles to the respiratory tract as a treatment for allergic sym ... | 2002 | 12653174 |
| hay fever and predictive value of prick test and specific ige antibodies: a prospective study in children. | little is known from population-based studies in children about the diagnostic values of allergen-specific ige antibodies (rast) and skin prick test (spt) with respect to hay fever. we aimed to determine and compare the diagnostic values of spt and rast to aeroallergens with respect to the incidence of hay fever cases in schoolchildren at different cut-off points. a prospective cohort study was performed on 1100 school children (5-7 and 8-10 years). information on a doctor's diagnosis of hay fev ... | 2003 | 12675758 |
| an association between plastic mattress covers and sheepskin underbedding use in infancy and house dust mite sensitization in childhood: a prospective study. | higher house dust mite (hdm) allergen exposure during infancy has been associated with increased hdm sensitization. infant bedding has been associated with the accumulation of varying levels of hdm. prospective data on the relationship between infant bedding and the development of hdm sensitization has not been previously examined. | 2003 | 12680864 |
| study on the prevention of allergy in children in europe (space): allergic sensitization in children at 1 year of age in a controlled trial of allergen avoidance from birth. | several studies have demonstrated that early intervention may modulate the natural course of atopic disease. our objective was to prevent sensitization to house-dust mite and food allergens, as well as the development of atopic symptoms during infancy, by the combination of an educational package and the use of mite allergen-impermeable mattress encasings. a multicentre european, population-based, randomized, controlled study of children at increased atopic risk [study on the prevention of aller ... | 2002 | 12688625 |
| [skin test reactivity to seven aeroallergens in a sousse area population sample]. | allergy skin tests are an important tool in the diagnosis of allergy diseases. they are useful in epidemiologic studies. | 2002 | 12703123 |
| endotoxin content of standardized allergen vaccines. | endotoxin is a ubiquitous and potent proinflammatory agent. previous limited studies suggest that it is pres-ent in allergen vaccines and that this could affect the safety and efficacy of allergen immunotherapy. the endotoxin content of standardized allergen vaccines is unknown. | 2003 | 12704357 |
| protective effects of a recombinant fragment of human surfactant protein d in a murine model of pulmonary hypersensitivity induced by dust mite allergens. | lung surfactant protein d (sp-d) is a carbohydrate pattern recognition immune molecule. it can interact with a range of pathogens, stimulate immune cells and manipulate cytokine profiles during host's immune response. sp-d has also been shown to interact, via its carbohydrate recognition domains, with glycoprotein allergens of house dust mite (dermatophagoides pteronyssinus, derp), inhibiting specific ige isolated from mite-sensitive asthmatic patients from binding these allergens, and blocking ... | 2003 | 12706535 |
| [acarofauna in the apartments of patients with perennial atopic rhinitis and functional tests of the respiratory system]. | prolonged exposure to house dust mites (hdm) of the pyroglyphidae family leads to the development of perennial allergic rhinitis (par) in sensitized subjects. in par patients bronchial hyperreactivity--the clinical manifestation of allergic inflammation in the lower airways is often observed. the aim of the study was to estimate the influence of the exposure to hdm in par patients on selected functional parameters of the lower airways. the study was performed on 64 patients with par caused by al ... | 2003 | 12712821 |
| wheezing, allergy, and parasite infection in children in urban and rural ethiopia. | epidemiological studies in developing countries suggest that intestinal parasite infection may reduce the risk of asthma. because this evidence is all derived from adults and older children, we have investigated the relation between parasite infection, wheezing, and allergen skin sensitization in nested case-control studies drawn from a survey of 7,155 children aged 1 to 4 years living in urban and rural areas of jimma, ethiopia. infection with parasites was common, predominantly with trichuris ... | 2003 | 12738598 |
| [nasal provocation tests with house dust mite in patients with perennial rhinitis]. | the aim of this study was to evaluate a response of the upper airways mucosae to allergens house dust mite: dermatophagoides farinae and dermatophagoides pteronyssinus. compared were results of nasal challenge with results of skin prick tests. 87 patients with perennial rhinitis allergic to dermatophagoides farinae and/or dermatophagoides pteronyssinus were included. there were 58 men, 29 women, age 18-54 years, mean age 26 years. nasal provocation tests were performed first with solvent, and ne ... | 2003 | 12741147 |
| sensitization to dermatophagoides pteronyssinus and blomia tropicalis extracts and recombinant mite allergens in atopic thai patients. | mite surveys in thailand indicated that dermatophagoides pteronyssinus (dp) is predominant, but so far there were no data available on blomia tropicalis (bt), which is prevalent in the asia pacific region. skin prick testing (spt) was performed in 40 atopic children, 45 atopic adults and 17 non-atopic volunteers. skin reactions to dp were found in 25/40 (62.5%) and 23/45 (51.1%); skin reactions to bt were found in 15/40 (37.5%) and 18/45 (40%) in atopic children and adults, respectively. spt to ... | 2002 | 12744621 |
| comparison of intradermal and serum testing for allergen-specific ige using a fcepsilon rialpha-based assay in atopic dogs in the uk. | atopic dermatitis in dogs is a common allergic skin disease that affects substantial numbers of dogs in the uk. the purpose of this study was to compare the results of an intradermal test (idt) and an in vitro test in a large cohort of dogs. dogs were intradermal tested with greer allergens (greer labs inc, lenoir, nc, usa) using standard techniques. at the same time blood samples were drawn and submitted for evaluation by elisa using the allercept definitive allergen panels for allergen-specifi ... | 2003 | 12753775 |
| acaricidal activity of tonka bean extracts. synthesis and structure-activity relationships of bioactive derivatives. | the acaricidal effects of tonka bean, dipterix odorata, extracts were investigated on dermatophagoides pteronyssinus, the european house dust mite, and compared with benzyl benzoate as a standard acaricidal compound. a cyclohexane extract was the most effective, with an ec(50) = 0.075 g/m(2) after a 24 h period, as compared with benzyl benzoate (0.025 g/m(2)). bioassay-guided fractionation of this extract led to the isolation of coumarin (1). pharmacomodulation of this compound led us to test 20 ... | 2003 | 12762809 |
| skin reactivity to histamine and to allergens in unselected 9-year-old children living in poland and italy. | several studies have shown a higher prevalence of positive skin-prick tests to airborne allergens in western than in eastern european countries. we have recently reported that skin histamine reactivity significantly increased in italy over the past 15 years. population differences in skin histamine reactivity could, at least in part, explain the reported differences in positive allergen skin tests. to test this hypothesis we compared histamine skin reactivity and the prevalence of allergen posit ... | 2003 | 12787299 |
| [relationship between dermatophagoides pteronyssinus and dermatophagoides farinae sige in serum and local secretion of perennial allergic rhinitis patients]. | to investigate the relationship between dermatophagoides pteronyssinus(dp) and dermatophagoides farinae(df) specific ige in the serum or local secretion of perennial allergic rhinitis (par) patients. | 2003 | 12833684 |
| mite and cockroach sensitization in allergic patients from caracas, venezuela. | mites and cockroaches are important allergen sources in most countries, especially in the tropics. they have been incriminated as the cause of the increased prevalence of inhalant allergen sensitization that has occurred in many areas of latin america. | 2003 | 12839327 |
| death in anaphylaxis in a man with house dust mite allergy. | up to recently the post-mortem diagnosis of anaphylaxis has been based solely on circumstantial evidence. with the development of assays for mast cell tryptase it is now possible to verify cases of suspected anaphylaxis. here we present one such case, which initially appeared to be due to sudden death of unknown cause. a 47-year-old farmer was found dead in his bathroom around midnight. hospital records revealed that he had previously been diagnosed with an allergy to house dust mites. he had al ... | 2003 | 12844219 |
| differences in mite fauna between the continental and mediterranean climates of croatia: microscopy and dustscreen test findings. | the aim of this study was to evaluate the difference between the mite fauna in the inland and coastal croatia. | 2003 | 12859558 |
| sensitization to different mite species in german farmers: in vitro analyses. | allergic airway diseases are often caused by house dust mites (hdm) and storage mites (sm), respectively, and we were recently able to demonstrate that symptomatic german farmers are frequently sensitized to different mite species. the present study aimed to obtain information on the protein and immunobiochemical characteristics of the extracts of the following mites: dermatophagoides pteronyssinus, dermatophagoides farinae, acarus siro, acarus farris, lepidoglyphus destructor, tyrophagus putres ... | 2003 | 12861848 |
| immune reactivity of recombinant group 2 allergens of house dust mite, dermatophagoides pteronyssinus, and dermatophagoides farinae. | the group 2 allergens of dermatophagoides pteronyssinus (der p) and dermatophagoides farinae (der f) are the major source of allergens for patients allergic to house dust mites (hdms). previous studies have reported the existence of several polymorphic residues of der p 2 and der f 2. in this study, recombinant group 2 allergens of der p (rder p 2) and der f (rder f 2) were produced in e. coli from the major isoforms of each cdna, in order to evaluate their usefulness for the detection and stand ... | 2003 | 12861849 |
| skin tests and conjunctival and bronchial challenges with extracts of blomia tropicalis and dermatophagoides pteronyssinus in patients with allergic asthma and/or rhinoconjunctivitis. | blomia tropicalis and dermatophagoides pteronyssinus are important mite species in tenerife, canary islands, spain. several studies have demonstrated a variable degree of allergenic cross-reactivity in vitro. however, only a few have addressed their allergenic cross-reactivity using challenge tests. | 2003 | 12876408 |
| hla class ii genotypic frequencies in atopic asthma: association of drb1*01-dqb1*0501 genotype with artemisia vulgaris allergic asthma. | different human leukocyte antigen (hla) class ii alleles have been associated with the development of atopic asthma. to determine whether hla class ii alleles are associated with atopic asthma in a population from southeast spain (murcia region), 213 atopic asthmatic patients and 150 controls were selected for hla typing. significant association of the drb1*01 and dqb1*0501 alleles was found in artemisia vulgaris allergic patients (p(c) = 0.00052 and p(c) = 0.00023, respectively). no significant ... | 2003 | 12878360 |
| usefulness of specific immunotherapy in patients with severe perennial allergic rhinitis induced by house dust mite: a double-blind, randomized, placebo-controlled trial. | to evaluate the effectiveness of specific immunotherapy (sit) in patients with severe house dust mite (hdm)-induced perennial allergic rhinitis using diary cards and objective endpoints. | 2003 | 12911781 |
| is the prevalence of specific ige to classical inhalant aeroallergens among patients with respiratory allergy changing? evidence from two surveys 15 years apart. | the aim of this study was to evaluate the relative frequencies of sensitisation to four common inhalant allergens in two atopic populations suffering from asthma and/or rhinitis. one had been studied in the period of 1975 till 1979, and a second population was evaluated between 1992 and 1995. | 2003 | 12945477 |
| the prevalence and diagnostic value of specific ige antibodies to inhalant, animal and plant food, and ficus allergens in patients with natural rubber latex allergy. | it is well recognised that natural rubber latex allergy can be associated with serological cross-reactivity to plant allergens, especially tropical fruits and ficus. in contrast, data on the frequency and clinical value of specific ige antibodies against these allergens remain rare. in addition, little is known about the prevalence and diagnostic value of specific ige antibodies to classical inhalant and animal allergens in nrl allergic patients. | 2003 | 12945478 |
| different antigens trigger different th1/th2 reactions in neonatal mononuclear cells (mncs) relating to t-bet/gata-3 expression. | neonates are known to have poor cellular immunity, especially poor th1 response. we investigated how neonatal mononuclear cells raised different th1/th2 reactions in response to different antigens. employing dermatophagoides pteronyssinus (der p) extract and varicella zoster virus (vzv) as antigens, we assessed th1/th2 reactions as demonstrated by il-4/ifngamma production and mrna expression, and transcriptional factors t-bet/gata-3 mrna expression in mononuclear cells from human umbilical cord ... | 2003 | 12960249 |
| human serum ige-mediated mast cell degranulation shows poor correlation to allergen-specific ige content. | although allergen-specific ige content in serum can be determined immunochemically, little is known about the relationship between this parameter and the strength of the degranulation response upon allergen triggering. | 2003 | 14510723 |
| cd4+cd25+ t cells lyse antigen-presenting b cells by fas-fas ligand interaction in an epitope-specific manner. | suppression by regulatory t cells is now acknowledged to play a key role in the down-regulation of t cell responses to foreign and self ags. in addition to the naturally occurring cd4(+)cd25(+) population, several subtypes of induced regulatory cells have been reported, but their mechanisms of action remain unclear. conversely, cytotoxic cd4(+) cells that lyse cells presenting their cognate peptide have been described, but their potential role in immunoregulation remains to be delineated. a cd4( ... | 2003 | 14568934 |
| detection of ige reactivity to fungus antigens by immunoblotting in allergic diseases in children. | fungi are well-known as sources for allergens that cause allergic rhinitis and allergic asthma. the aim of this study was to evaluate the prevalence of sensitization to airborne fungi in allergic diseases in children. | 2003 | 14604308 |