| host defenses in murine malaria: induction of a protracted state of immunity with a formalin-killed plasmodium berghei blood parasite vaccine. | random-bred mice were immunized with a nonliving antigen prepared from mixed-blood forms of plasmodium berghei, strain nyu-2, in combination with corynebacterium parvum and/or living bcg. a high proportion of intravenously immunized mice survived virulent challenge, but subcutaneous vaccination was less effective. vaccinated mice developed a patent infection after challenge similar to that observed in normal controls. however, between days 12 to 20 postchallenge, infections in some vaccinated mi ... | 1978 | 365770 |
| a comparative study of malaria prophylaxis in peninsular malaysia using chloroquine and a combination of sulphadoxine and pyrimethamine. | | 1978 | 366165 |
| malaria prophylaxis for visitors to papua new guinea. | | 1978 | 366358 |
| malaria: a new facet of heroin addiction in australia. | a case of vivax malaria is described. the patient, who had occasionally abused heroin intravenously, shared injection equipment with an addict who had previously contracted malaria in southeast asia and who had failed to complete an adequate course of treatment. | 1978 | 366360 |
| chloroquine-resistant falciparum malaria. | | 1978 | 366363 |
| the treatment of malaria. | | 1978 | 366774 |
| some aspects of epidemiology of resurgent malaria in turkey. | the resurgence of autochthonous plasmodium vivax malaria in turkey is a matter of considerable concern. anopheles sacharovi is the important vector but other species, notably a. superpictus, may play a role in transmission. the epidemiology is discussed in terms of factors related to the mosquito, factors related to the human host and human ecology as it affects dispersal of the parasite. although the development of insecticide resistance is grave, the present situation is mainly attributable to ... | 1978 | 366812 |
| chronic malarial infection of mice: a comparison of single and multiple infections with plasmodium berghei following p. yoelii. | chronic malarial infection was induced in two groups of balb/c mice by injection of plasmodium yoelii followed by either one or repeated injections of p. berghei. both groups showed a continuing but fluctuating splenomegaly, and a considerably increased reticulocyte count which also varied regularly, over a period of six months. during this time many mice had a very low grade parasitaemia demonstrable by subinoculation of blood into uninfected recipients. mice infected with p. yoelii alone did n ... | 1978 | 366816 |
| hypocomplementaemia in children with plasmodium falciparum malaria. | | 1978 | 366818 |
| removal of leucocytes from red cells in plasmodium berghei-infected mouse blood and purification of schizont-infected cells. | | 1978 | 367300 |
| the protective effect of endogenous interferon in mouse malaria, as demonstrated by the use of anti-interferon globulins. | both death rate and percentage of parasitized erythrocytes in mice infected with plasmodium berghei were enhanced by injections of anti-interferon globulins. as, in the same time, parasite-induced interferon was neutralized by these globulins, it can be concluded that endogenous interferon plays an important inhibiting role during parasitic diseases, such as malaria, as it has been previously demonstrated in many virus infections. | 1978 | 367460 |
| malaria in birmingham and a london teaching hospital. | during the past five years the incidence of imported malaria increased among patients seen in east birmingham hospital and in st thomas's hospital, london. plasmodium vivax was the predominant species in birmingham, and was almost always acquired by asian immigrants visiting the indian subcontinent. in st thomas's p falciparum was most commonly imported, usually by african immigrants visiting nigeria and ghana. two patients (one irish, one japanese) died of falciparum malaria after visiting trop ... | 1979 | 367507 |
| severe falciparum malaria during a blizzard. | | 1979 | 367562 |
| [tertian malaria in children and adults from an epidemic region in southern turkey (author's transl)]. | since 1974 an epidemic of tertian malaria has been spreading around the adana and tarsus townships in southern turkey, with a peak incidence of 115 500 cases in 1977. a further increase is to be expected because the insect vectors have become resistant to insecticides. since 1975 eleven children and three adults have been treated for p. vivax malaria. they had all stayed in the epidemic area during the transmission season which lasts from july to october. because of a long primary latent period ... | 1979 | 367741 |
| immunofluorescent staining of exoerythrocytic schizonts of plasmodium berghei in fixed liver tissue with stage-specific immune serum. | | 1978 | 368305 |
| chloroquine-resistant falciparum malaria. | | 1979 | 368534 |
| [congenital malaria in a greek twin (author's transl)]. | a case of congenital malaria due to plasmodium malariae in one of two living greek twins born in germany is presented. in the child fever, anaemia and hepatosplenomegaly were first noticed at the age of two months. plasmodium malariae parasites were demonstrated in the peripheral blood and bone marrow. the sera of mother and infant contained malaria antibodies. however the mother never showed clinical signs of malaria. diagnosis and therapy of congenital malaria and the possible mode of transmis ... | 1979 | 368608 |
| applications and possibilities of cytophotometry for red cell hematology. | | 1978 | 368884 |
| venezuelan strains of plasmodium falciparum resistant to sulfa and pyrimethamine as demonstrated by in vitro test. | | 1977 | 368932 |
| [continuous axenic culture of mammalian plasmodia. i. plasmodium berghei]. | | 1977 | 368933 |
| a susceptible and refractive strain of anopheles atroparvus van thiel to infection with plasmodium berghei berghei. | | 1977 | 369264 |
| labelling of plasmodium berghei during sporogony. | | 1977 | 369268 |
| [in vivo formation of myelin-like forms in mouse erythrocytes infested by plasmodium berghei (author's transl)]. | | 1978 | 369437 |
| the activity of chloroquine against plasmodium falciparum in bandar abbas, southern iran, 1976. | study to monitor the susceptibility of p. falciparum to chloroquine in south iran was conducted in bandar abbas. forty-five falciparum malaria subjects who had received 25mg. chloroquine base per kg. body weight over 3 days were followed up for 4 weeks, while three other patients for a period of 1-3 weeks. no recrudescence could be confirmed among the subjects during the follow up of the study. the mean time of asexual parasites clearance was 2.15 days. the action of chloroquine against the asex ... | 1978 | 369728 |
| [malaria caused by accidental inoculation. 1 case]. | the authors report a case of direct infection of a nurse who had taken blood sample from a young patient suffering from malaria due to plasmodium falciparum. six similar observations have been reported in the literature. in addition, accidental infection has been observed following the use of non sterile syringes. as a result, malaria could be an unexpected consequence of the drug habit. | 1978 | 369732 |
| changes in serum, liver, fat pad and thymus lipid levels in adult rats infected with plasmodium berghei. | | 1977 | 370086 |
| antimalarials. 4. trichloronaphthalene amino alcohols. | an improved procedure for the synthesis of naphthalene amino alcohols is described. four new compounds were prepared and tested by rane laboratories for activity vs. plasmodium berghei in mice. all compounds were active, the most active being 1-[3-(4-chlorophenyl)-5,7-dichloro-1-naphthyl]-3-(di-n-butylamino)propanol hydrochloride (16b). structure--activity relationships between the naphthalene and quinoline isosteres are discussed. | 1979 | 370389 |
| chloroquine resistance in malaria: accessibility of drug receptors to mefloquine. | the process of mefloquine accumulation was studied in mouse erythrocytes infected with either plasmodium berghei cs (chloroquine susceptible) or p. berghei cr (chloroquine resistant). in both cases, mefloquine was accumulated by a saturable process with an apparent dissociation constant of 2.5 x 10(-6) m and an apparent maximal capacity of 700 mumol per kg of erythrocyte pellet; uninfected mouse erythrocytes accumulated more than half as much mefloquine as infected erythrocytes. the process of a ... | 1979 | 371544 |
| the role of platelets in infections. i. observations in human and murine malaria. | the interaction between platelets and microorganisms may be underestimated. our in vivo studies support a direct role of thrombocytes in malarial infections. we have found intrathrombocytic parasites of plasmodium vivax (in 10% of men naturally infected) and p berghei (in 53% of mice experimentally infected); these were both merozoites and trophozoites. neither the mechanism of parasitization (whether by active penetration or by phagocytosis) nor the outcome of this phenomenon is known. however, ... | 1979 | 371580 |
| separation of plasmodium berghei-parasitized rat erythrocytes by means of carrier-free electrophoresis. | a carrier-free electrophoresis apparatus was used to isolate rat erythrocytes parasitized with plasmodium berghei. the region of high electrophoretic mobility yielded noninfected erythrocytes, whereas that of low electrophoretic mobility yielded erythrocytes infected with viable parasites. over 98% purity of parasitized erythrocytes was obtained when blood at an advanced stage of parasitaemia was used. merozoite-rich fractions were also observed. this continuous one-step separation method should ... | 1979 | 371849 |
| concentration and separation of erythrocytes infected with plasmodium falciparum by gradient centrifugation. | concentration of infected erythrocytes was achieved in cell suspensions derived from long-term culture of plasmodium falciparum growing asynchronously in human erythrocytes. this new procedure involves the slow centrifugation (at 33 g) of erythrocyte suspensions through 5% ficoll solutions. mature asexual erythrocytic forms are preferentially retained in the gradient solution (top fraction). after further gradient centrifugation of these parasitized cells, the concentration of mature forms is in ... | 1979 | 371850 |
| direct coombs antiglobulin reactions in gambian children with plasmodium falciparum malaria. i. incidence and class specificity. | gambian children with past or present plasmodium falciparum malaria were investigated for the incidence of coombs positivity using monospecific antisera. approximately 50% were positive and the most frequent form of erythrocyte sensitization was with c3d. other specificities, eigg, eiggc3d and eiggc4bc3d were less common. erthyrocytes were never found sensitized with iga or igm. there was no correlation between a positive test and age, tribal status or level of parasitaemia at presentation, alth ... | 1979 | 371880 |
| distribution of human plasmodia in karnataka and tamil nadu states in the reappearing phase of malaria in 1970 and 1975. | | 1979 | 372102 |
| quantitative structure-activity relationships in 1-aryl-2-(alkylamino)ethanol antimalarials. | a quantitative structure-activity relationship has been formulated for 646 antimalarials acting against p. berghei in mice. the equation developed has 14 terms, 9 of which are indicator variables. the correlation coefficient for the qsar is 0.898 and the standard deviation is 0.309. the antimalarials are all arylcarbinols of the type x-archohch2nr1r2. sixty different aryl structures, including a variety of heterocyles, are contained in the study. the most important determinate of activity is fou ... | 1979 | 372527 |
| [autopsy case of plasmodium falciparum malaria]. | | 1978 | 372631 |
| the ribosomes of plasmodium berghei: isolation and ribosomal ribonucleic acid analysis. | ribosomes and high molecular weight ribosomal ribonucleic acid (rrna) from the blood stages of plasmodium berghei parasites were studied in preparations free from host ribosome contamination. purified malarial ribosomes were isolated in high yield from a population of ultrastructurally intact, viable parasites by hypertonic lysis with triton x-100 and differential centrifugation. these ribosomes were shown to be derived from active polysomes and could be dissociated into subunits by puromycin-0. ... | 1978 | 372893 |
| clearance of falciparum parasitaemia with a single dose sulfadoxine-pyrimethamine in vientiane, laos. | a total of 49 semi-immune laotians aged 3 to 49 years, with falciparum malaria were treated with a single dose of sulfadoxine pyrimethamine (1500 mg, 75 mg, adult dose), in vientiane, laos. on day 7 after treatment the 49 cases were asymptomatic with complete disappearance of patent asexual parasitaemia. the result is compared with that obtained from treating 48 similar cases with a standard dose of chloroquine over 3 days. | 1978 | 373131 |
| the experimental infection of anopheles litoralis king from luzon island, philippines, by plasmodium vivax. | | 1978 | 373132 |
| [course and intensive treatment of acute falciparum malaria (author's transl)]. | the case of a nineteen-year-old women with the cerebral form of malaria tropica is reported. she showed hyperpyrexia, abdominal manifestations, haemolysis and disseminated intravascular coagulation. cerebral symptoms amounting to grade iv encephalopathy occurred. the patient responded rapidly to the administration of chloroquine, anticonvulsants, dextran, corticosteroids, antipyretics, blood and antithrombin iii and her symptoms had almost completely vanished one week after the onset of therapy. | 1979 | 373259 |
| effect of temperature and clofibrate on plasmodium berghei infection in mice. | parasitemia counts established that 22 degrees c-acclimated mice subjected to cold exposure for a short time (-35 degrees c for 30 min) during plasmodium berghei infection had significantly higher parasitemia levels than parasitized mice continuously housed at 22 degrees c. parasitized 5 degrees c-acclimated mice also demonstrated higher parasitemia levels than parasitized 22 degrees c-acclimated mice. there was no correlation between plasma free fatty acid (pffa) concentration and parasitemia i ... | 1979 | 373470 |
| host defenses in murine malaria: successful vaccination of mice against plasmodium berghei by using formolized blood parasites. | infections of normal icr mice with the nyu-2 strain of plasmodium berghei (pb) are uniformly fatal. however, a proportion of mice that have been vaccinated with a formalin-killed antigen prepared from the blood stages of pb survive an otherwise lethal challenge. such immunity is not induced by immunization with normal mouse erythrocytes. the level of acquired anti-malarial immunity is related to the size and number of doses of antigen, and intravenous injection is superior to the subcutaneous ro ... | 1979 | 373471 |
| hepatic dysfunction in childhood malaria. | hepatic function of 80 children aged under 3 years with plasmodium vivax malaria were studied during the acute attack and 6 weeks after antimalarial treatment. raised levels of serum aspartate transaminase (serum ast; sgot), serum alanine transaminase (serum alt; sgpt), and alkaline phosphatase were observed in 68%, 39% and 46% of cases respectively. ast levels were higher than alt ones and the mean level of both enzymes was much higher in patients with hepatomegaly. the hepatic dysfunction whic ... | 1979 | 373643 |
| single-dose therapy of falciparum malaria with mefloquine or pyrimethamine-sulfadoxine. | a single oral dose (1.5 g) of mefloquine hydrochloride cured all of 37 patients with falciparum malaria, and a single dose of pyrimethamine (75 mg) plus sulfadoxine (1.5 g) cured 34 of 38 patients. the rates at which parasitaemia and fever abated were similar for the two regimens but mefloquine was associated with a higher incidence of gastrointestinal side effects. | 1979 | 373903 |
| loss of circulating t lymphocytes with normal levels of b and 'null' lymphocytes in thai adults with malaria. | peripheral blood mononuclear cells from forty-nine thai adults infected with either plasmodium falciparum or plasmodium vivax were examined in order to determine the percentage of t, b, and fc-receptor-bearing cells present. in comparison to healthy controls, both the percentage and concentration of peripheral t cells were decreased in the malaria-infected individuals as assessed by formation of rosettes with sheep red blood cells. the percentage of peripheral b cells was increased but their co ... | 1979 | 373935 |
| plasmodium berghei: correlation of in vitro erythrophagocytosis with the dynamics of early-onset anemia and reticulocytosis in mice. | | 1979 | 374106 |
| experimental studies of schistosomal pigment from schistosoma japonicum. | the schistosomal and malarial pigments were distinguishable before and after extraction from the host liver. presence of iron in both pigments was ascertained by the elemental x-ray analysis. histochemically, however, schistosomal pigment was similar to that of malarial pigment. | 1979 | 374107 |
| immunosuppression in murine malaria. iii. induction of tolerance and of immunological memory by soluble bovine serum albumin. | the primary antibody response to alumadsorbed bsa was depressed when initiated during low-grade chronic plasmodium berghei malaria in mice, as previously reported during acute p.y. yoelii infection. induction of immunological memory by soluble polymerized bsa was abolished in both infections; in infected hosts this normally immunogenic stimulus resulted in partial tolerance. in contrast to the depression of immune response, neither infection interfered with the induction of low-zone tolerance by ... | 1979 | 374257 |
| determination of antibody titres in human malaria using the indirect haemagglutination test. | | 1978 | 374268 |
| plasmodium vivax malaria in the neonatal period. | | 1978 | 374271 |
| occurrence of malaria acquired during travel abroad among american civilians, 1970-1976. | | 1979 | 374645 |
| phenazines with two cationic side chains as potential antimalarials. | 1,9-phenazine-bis(dialkylaminocarboxamides) were prepared for screening as potential antimalarials. no significant activity against plasmodium berghei was observed. the phenazine targets were prepared from 1,9-phenazinedicarboxylic acid by standard methods. the reaction between 1,9-phenazinedicarboxylic acid and thionyl chloride in the presence of dimethylformamide unexpectedly gave 4-chloro-1,9-phenazinedicarbonyl chloride. | 1979 | 374708 |
| [malaria in switzerland. clinical diagnosis and management schedule for the practitioner (author's transl)]. | | 1979 | 375456 |
| treatment of vivax malaria with sulfadoxine-pyrimethamine and with pyrimethamine alone. | the effect of pyrimethamine and the combination of pyrimethamine-sulfadoxine (fansidar) upon the termination of the acute attack of vivax malaria was studied in thailand. pyrimethamine was found to be ineffective, providing clearance of parasitaemia in only two of six patients by the end of seven days following treatment. the combination, administered in a two-tablet single dose (sulfadoxine 1 gm, pyrimethamine 50 mg) eliminated parasitaemia in only six of ten patients within seven days. three t ... | 1979 | 375485 |
| serum immunoglobulin levels and malaria antibodies in burkitt's lymphoma. | data are presented to support a relationship between malaria infection and burkitt's lymphoma in african children. igg, igm and iga levels were measured in sera from burkitt's lymphoma patients and from sex- and age-matched, nearest-neighbour controls. all three classes of immunoglobulins were present in significantly lower amounts in the sera from burkitt's lymphoma patients than in the sera from controls. the mechanism of this apparent b-cell suppression is not yet clear. malaria-specific igg ... | 1979 | 375487 |
| [further observations of the course of plasmodium berghei infection in the mouse]. | invasion of immature and mature erythrocytes by merozoites of plasmodium berghei seems to obey the following rules: merozoites prefer unparasitized immature erythrocytes. multiple infections of immature erythrocytes occur in conditions of high merozoite production and low concentration of unparasitized immature erythrocytes, when frequently repeated contacts between merozoites and unparasitized or freshly parasitized immature erythrocytes become increasingly probable. mature erythrocytes are inv ... | 1979 | 375509 |
| lymphocyte changes in murine and human malaria. | | 1979 | 375510 |
| protection of mice against plasmodium and babesia infections: attempts to raise host-protective sera. | in an attempt to generate large numbers of mice resistant to plasmodium berghei and babesia rodhaini to be used as donors of antibody-secreting cells for hybridoma production, various methods of inducing resistance to repeated challenge with infected blood cells have been explored. although results of independent experiments varied markedly, prior injection of cba/m mice with bcg, and prior infection of balb/c mice with plasmodium yoelii, were found to be manipulations capable of inducing resist ... | 1978 | 375903 |
| falciparum malaria despite chemoprophylaxis. | | 1979 | 376057 |
| plasmodium berghei: effect of antithymocyte serum on induction of immunity in the mouse. | | 1979 | 376327 |
| urban malaria and its vectors in salem (tamil nadu): natural and induced infection with human plasmodia in mosquitoes. | | 1979 | 376440 |
| intravascular clearance of parasitized erythrocytes in rodent malaria. | little is known about host defense mechanisms responsible for protective immunity in malaria. the intravascular location of the infection suggested that removal of parasitized erythrocytes by reticuloendothelial organs might be important. to study this possibility, we examined the clearance of (51)crlabeled plasmodium berghei-infected erythrocytes in rats. infected erythrocytes were removed more rapidly from circulation than homologous uninfected erythrocytes. the rate of clearance of infected c ... | 1979 | 376554 |
| circulating and tissue-bound immune complex formation in murine malaria. | immune complex formation during plasmodium berghei infection of of1 mice was investigated. circulating immune complexes (cic) were detected by the clg-binding assay and the conglutinin-binding solid-phase assay in lethal or drug-limited infections. cic appeared on day 9 of infection, peaked on day 11, and disappeared only after complete cure of the infection. analysis of the immune complexes detected by the clq-binding assay revealed the following characteristics: sedimentation coefficients of 1 ... | 1979 | 376733 |
| hemolymph of anopheles stephensi from uninfected and plasmodium berghei-infected mosquitoes. 2. free amino acids. | determinations were made of free amino acids in hemolymph collected from adult female anopheles stephensi mosquitoes. the hemolymph first was fractionated by extraction and precipitation procedures, after which qualitative determinations of free amino acids were made by high voltage thin layer electrophoresis, and thin layer chromatography. subsequent quantitative determinations were made with an automatic amino acid analyzer. the concentration of total free amino acids in the hemolymph rose 60- ... | 1979 | 376812 |
| hemolymph of anopheles stephensi from noninfected and plasmodium berghei-infected mosquitoes. 3. carbohydrates. | determinations were made of carbohydrates in hemolymph collected from adult female mosquitoes (anopheles stephensi). first the hemolymph was fractionated by extraction and precipitation procedures, after which qualitative and quantitative determinations of carbohydrates were made by thin layer chromatography. the most abundant sugars found in the hemolymph were glucose and trehalose, though maltose, glucuronic acid, and inositol could be found after the mosquitoes took blood meals. after the mos ... | 1979 | 376818 |
| isolation of plasmodium berghei by hemolysin lysis of infected erythrocytes and evidence for a parasite hexokinase. | a rapid and simple procedure has been developed for the isolation of plasmodium berghei parasites from infected-mouse erythrocytes employing the heat stable hemolysin produced by pseudomonas aeruginosa. using parasites isolated by this method, the presence of a parasite specific hexokinase has been demonstrated, providing an explanation for the increased glucose consumption observed with infected cells. enzyme assays and serology were employed in determining the purity and yield of purified para ... | 1979 | 376819 |
| 2-acetylpyridine thiosemicarbazones. 1. a new class of potential antimalarial agents. | based on the antimalarial properties observed for 2-acetylpyridine 4-phenyl-3-thiosemicarbazone (1), an extensive series of related thiosemicarbazones was prepared and tested against plasmodium berghei in mice. screening results indicated that the presence of the 2-pyridylethylidene group was critical and that certain phenyl, benzyl, phenethyl, or cycloalkyl groups at n4 of the thiosemicarbazone moiety also contribute to antimalarial activity. | 1979 | 376848 |
| dipeptides of o-methyl-l-threonine as potential antimalarials. | l-leucyl-o-methyl-l-threonine, o-methyl-l-threonyl-l-leucine, and o-methyl-l-threonyl-o-methyl-l-threonine were prepared and compared with o-methyl-l-threonine and l-leucine for antimalarial activity against plasmodium berghei in mice. o-methyl-l-threonine significantly prolonged survival time at doses of 160, 320, and 640 mg/kg. o-methyl-l-threonyl-o-methyl-l-threonine was less active, significantly prolonging survival time only at 640 mg/kg. l-leucine, as well as the other two dipeptides, exhi ... | 1979 | 376849 |
| immunizations for travelers. | | 1979 | 377044 |
| oxidant damage mediates variant red cell resistance to malaria. | | 1979 | 377105 |
| immunosuppression induced by plasmodium berghei and p. chabaudi infections in mice. | | 1978 | 377186 |
| [transmission of plasmodium falciparum malaria by syringe in a patient with heroinism]. | | 1979 | 377220 |
| spleen plays major role in removal from bloodstream of malaria-infected rbcs. | | 1979 | 377364 |
| [imported tropical malaria in pregnant women]. | | 1979 | 377517 |
| [errors in the diagnosis of malaria]. | | 1979 | 377805 |
| the use of exchange transfusions: a potentially useful adjunct in the treatment of fulminant falciparum malaria. | fulminant falciparum malaria with greater than 500,000/mm3 parasites in the peripheral blood portends a poor prognosis. we recently managed a patient who had greater than 1.2 million/mm3 parasitized erythrocytes in her peripheral blood, following initially inadequate antimalarial therapy, with exchange transfusion in addition to conventional chemotherapy. this patient recovered from her disease despite severe cerebral involvement and acute failure. we feel that exchange transfusion was a useful ... | 1979 | 377965 |
| therapeutic use of exchange transfusion in malaria. | in the case reported here, a patient with severe plasmodium falciparum infection with 20% of erythrocytes parasitized was cured by exchange transfusion in conjunction with classical drug therapy. | 1979 | 378004 |
| phosphorylation of membrane proteins from plasmodium berghei-infected red cells. | | 1979 | 378225 |
| [chloroquine-resistant tropical malaria following a trip to kenya]. | | 1979 | 378630 |
| plasmodium falciparum: continuous cultivation in a semiautomated apparatus. | | 1979 | 378679 |
| selection of pyrimethamine resistant strain of plasmodium berghei. | | 1979 | 378824 |
| response of sensitized and unsensitized human lymphocyte subpopulations to plasmodium falciparum antigens. | antigen preparations derived from plasmodium falciparum-infected erythrocytes (but not from uninfected erythrocytes) can stimulate the in vitro proliferation of peripheral blood lymphocytes from malaria-sensitized as well as nonsensitized donors. the possibility that the nonspecific responses might be due to a parasite-derived b-cell mitogen has been previously suggested since polyclonal hypergammaglobulinemia is a frequent accompaniment of malaria infection. to test this hypothesis, we investig ... | 1979 | 378840 |
| resistance to babesia spp. and plasmodium sp. in mice pretreated with an extract of coxiella burnetii. | mice injected intravenously with a commercially available extract of coxiella burnetii prepared for use as the antigen in the complement fixation diagnostic test for q fever were subsequently resistant to infection with babesia microti, babesia rodhaini, and plasmodium vinckei petteri. the parasites appeared to die inside circulating erythrocytes. protection was unaffected by exposing the pretreated mice to 900 rads on the day before they were infected. to explain these findings, it is postulate ... | 1979 | 378850 |
| haemoglobin s and p. falciparum malaria. | | 1979 | 379655 |
| [malaria tropica with coma in early infancy (author's transl)]. | after arriving in austria a 10 month old nigerian infant fell sick with malaria tropica and survived after specific antiparasitic therapy. early diagnosis and immediate begin of treatment are stressed. | 1979 | 380183 |
| nutritional studies of the south eastern state peasant diet: studies of the effect of malarial infection (plasmodium berghei) on electrolyte changes in rats fed the peasants' diet. | 1. plasmodium berghei (malaria infection) is not specifically related to the nutritional status of the host though nutritional status may aid the advance or elimination of the parasite. 2. the effect of the infection is more severe in low protein diets than in diets whose protein content was adequate. 3. there was no evidence of excessive urinary excretion of electrolytes in the infected rats. 4. it is suggested that low plasma levels of electrolytes in the infected rats were due to skin losses ... | 1978 | 380218 |
| plasmodium gallinaceum-parasitized chicken erythrocytes in a practical hemagglutination test for igm antibodies in human malaria. | a new hemagglutination test for human malaria, done with plasmodium gallinaceum-parasitized, aldehyde-fixed, chicken erythrocytes as a stable lyophilized reagent, is described. the test was positive in every human case of falciparum or vivax malaria in which there was parasitemia. it detected only igm anti-plasmodial antibodies and usually became negative within a few weeks after treatment. as a practical and sensitive test for active malaria, the p. gallinaceum hemagglutination test should be c ... | 1979 | 380370 |
| fansidar for falciparum malaria. | | 1979 | 380540 |
| falciparum malaria despite chemoprophylaxis. | | 1979 | 380749 |
| pulmonary oedema in the falciparum malaria. | | 1979 | 380762 |
| acute urticaria due to plasmodium falciparum infection. a report of two cases with a review of the english literature. | | 1979 | 380958 |
| dissociative effects of malarial infection on humoral and cell-mediated immunity in mice. | the effect of malarial infection on immune responses was studied in mice. when sheep red blood cells (srbc) were injected 2 days before or at the same time as infection with plasmodium berghei, there was a marked increase in the number of splenic plaque forming cells (pfc) induced by srbc as compared with uninfected controls. when srbc were injected 2 days or more after the infection, however, the pfc response was significantly reduced. on the other hand, cell-mediated immunity, as exemplified b ... | 1979 | 381176 |
| a note on in vivo chloroquine sensitivity tests in p. falciparum in some parts of karnataka state. | | 1979 | 381190 |
| results of 5-day course of radical treatment of plasmodium vivax in six districts of tamil nadu. | | 1979 | 381191 |
| alterations in some biochemical parameters in mouse liver and spleen during infection with plasmodium berghei. | | 1979 | 381192 |
| host defenses in murine malaria: analysis of the mechanisms of immunity to plasmodium berghei generated in response to immunization with formalin-killed blood-stage parasites. | syngeneic b6d2f1 (c57bl/6 x dba/2) mice were immunized with a nonliving antigen prepared from mixed blood forms of plasmodium berghei strain nyu-2. consistently greater than 80% of the vaccinated mice survived virulent challenge, and protective immunity was demonstrable from 1 week through at least 4 months after immunization. however, vaccination did not prevent the development of patient infection after challenge. instead, infections in vaccinated mice progressed to about 10% parasitemia and w ... | 1979 | 381198 |
| electron microscopy of cerebral malaria in golden hamsters (mesocricetus auratus) infected with plasmodium berghei. | transmission and scanning electron microscopy of hamster cerebral malaria show that haemorrhages occur following vessel necrosis in animals with low parasitaemias. there is no concurrent thrombosis nor packing of capillaries with parasitised erythrocytes. small vessels contain numerous monocytes which have phagocytosed erythrocytes and smaller particles of similar electron density. the monocytes attach to and migrate through the endothelium but then remain in close proximity to the vessels. irre ... | 1979 | 381611 |
| immunopathological studies of plasmodium berghei infected mice: (effect of carbon particles). | an attempt was made to block the role of the macrophages in the immune response by saturating them with carbon particles. the experiment was performed on swiss albino female mice injected intraperitoneally with 10(5) p. berghei berghei. these mice were injected with carbon particles of 20 mgs on the day before the inoculation and again 10 mgs on day 4 and day 9 after the inoculation. the degree of parasitaemia was slightly higher throughout the experiment in the infected mice treated with carbon ... | 1979 | 381681 |
| sporozoite-induced malaria: therapeutic effects of glycolipids in liposomes. | liposomes containing neutral glycolipids with a terminal glucose or galactose, when injected intravenously, prevented the appearance of erythrocytic forms of malaria (plasmodium berghei) in mice previously injected with sporozoites. inhibitory glycolipids included glucosyl, galactosyl, or lactosyl ceramide. inhibition was not observed with liposomes containing ceramide, phosphocholine ceramide, sulfogalactosyl ceramide (sulfatide), or ganglioside gm1. liposomes containing glycolipids did not inh ... | 1979 | 382358 |
| partial characterization of a malaria mitogen. | supernatants from 24-hour cultures of plasmodium falciparum-infected human red blood cells stimulated lymphocytes from both malaria immune and malaria non-immune donors. both t and b lymphocytes responded. amalaria parasite-derived mitogen may play some part in the pathogenesis of the hypergammaglobulinaemia characteristic of malaria. | 1979 | 382464 |
| frequency of blood group antigens in nigerian children with falciparum malaria. | the frequencies of the following blood group antigens: a, b, o, m, n, s, s, u, fya, fyb, lea, jsa and k have been determined in nigerian children with severe falciparum malaria. the frequency distribution of m, n, s, s, u, fya and fyb were not significantly different in children with life-threatening falciparum malaria and controls. the frequencies of a, b, o, lea, jsa and k found in the children with severe malaria were similar to those previously reported for healthy adults in this population. ... | 1979 | 382466 |