[experiment in reproducing experimental tuberculosis of the eye]. | | 1977 | 411131 |
bactericidal activity of streptomycin, isoniazid, rifampin, ethambutol, and pyrazinamide alone and in combination against mycobacterium tuberculosis. | log-phase cultures of mycobacterium tuberculosis in tween-albumin medium were exposed to streptomycin, isoniazid, rifampin, ethambutol, and pyrazinamide in concentrations in the range likely to be present in serum during treatment of patients. the bactericidal activity of the drugs was measured as the decrease in viable counts at 4 and 7 days. the activity of single drugs was highest for streptomycin and next highest for rifampin and isoniazid, but ethambutol only started to kill after 4 days. w ... | 1977 | 411404 |
controlled trial of intermittent regimens of rifampin plus isoniazid for pulmonary tuberculosis in singapore. the results up to 30 months. | | 1977 | 411405 |
drug resistant tuberculosis in a large southern california hospital. | rates of in vitro resistance to antituberculous drugs were examined for all patients hospitalized with active tuberculosis between january 1969 and december 1972, and between march 1975 and september 1976. during the former period, in 31.5 per cent of patients, tuberculosis was resistant to one or more drugs, and in 12.3 per cent of patients was resistant to 2 or more drugs. during the latter period, 35.5 per cent of patients had tuberculosis that was resistant to one or more drugs, and 19.6 per ... | 1977 | 411406 |
bronchial findings in pulmonary tuberculosis. | a total of 297 bronchoscopies were performed on 238 patients with pulmonary tuberculosis at the paivarinne chest hospital during the period 1967--1973. the tuberculous process was deemed active in 172 patients and inactive in 66. active endobronchial tuberculosis was diagnosed in 20 patients, 11.6% of the active cases, whereas inactive sequelae of endobronchial tuberculosis appeared in 7% of the total material. bronchography was performed on 163 patients; a normal bronchogram was obtained in 54% ... | 1977 | 411618 |
diagnosis of tuberculosis today. | | 1977 | 411624 |
adjuvant activities of chemically modified water-soluble substances from mycobacterium tuberculosis. | water-soluble peptidoglycan fragments extracted from the cells of two strains of mycobacterium tuberculosis var. hominis were chemically conjugated with lauric or with palmitic acid. the coupling reaction was confirmed by physicochemical procedures. the native and the fatty acid-conjugated substances were studied for their adjuvant activity in the induction of delayed type hypersensitivity (dth) reactions in guinea-pigs and on the production of circulating antibodies in the rabbit. palmitic acid ... | 1977 | 411741 |
study of mycobacteria isolated from cases of bone and joint tuberculosis. | | 1977 | 411742 |
role of cellwall vaccine in prophylaxis of tuberculosis. | | 1977 | 411743 |
estimation of number of repeat examinations required to detect all tuberculosis cases in the community. | | 1977 | 411750 |
potentiation of mouse peritoneal macrophage antibacterial functions by treatment of the donor animals with the methanol extraction residue fraction of tubercle bacilli. | administration to inbred mice of the methanol extraction residue fraction of tubercle bacilli by some, but not by all, routes affected markedly the in vitro phagocytic and antibacterial capacities of their peritoneal macrophages harvested several days to weeks after treatment. phagocytosis of living [3h]thymidine- labeled staphylococcus albus and staphylococcus aureus organisms, but not of listeria monocytogenes, was markedly enhanced. uptake of the deoxyribonucleic acid precursor thymidine by t ... | 1977 | 411756 |
the immune response in acute myelocytic leukemia: effect of the methanol extraction residue fraction of tubercle bacilli (mer) on t and b cell functions and their relation to the course of the disease. | | 1977 | 411767 |
characterization of ten species of mycobacteria by reaction-gas-liquid chromatography. | the methanolic tetramethylammonium hydroxide whole-cell lysates of nine species of mycobacteria and the "rhodochrous complex" were examined by gas-liquid chromatography. the gas chromatographic patterns produced 10 characteristic chromatographic groups that corresponded to the 10 species studied. the gas chromatograms of mycobacterium tuberculosis were very easily distinguished from the other mycobacterial strains by high levels of a component that eluted much later than the other components. th ... | 1977 | 411804 |
subclinical infection with mycobacteria in southern iran. | in 50 non-tuberculous adult patients hospitalized in the pahlavi university medical center skin testing with 5 tuberculin units of purified protein derivative of mammalian mycobacterium tuberculosis (ppd-m) and equivalent amounts of antigen from mycobacterium kansasii (ppd-y) and mycobacterium gause (ppd-g), as well as 0.1 ml mumps antigen was carried out. thirty four per cent, 26 per cent and 12 per cent of the patients had induration greater than 10 mm in diameter to ppd-m, ppd-y and ppd-g res ... | 1977 | 412163 |
[relapse of tuberculosis in poland. i. bacteriological, radiographic and clinical structure of relapses and new cases]. | | 1977 | 412173 |
[epidemiology of primary drug resistance in tuberculosis in the federal republic of germany including berlin (west) during 1972 to 1975 (author's transl)]. | | 1977 | 412177 |
[evolution of urinary tract tuberculosis in switzerland during the last 18 years: respective diagnostic importance of radiology and bacteriology]. | in switzerland as in other european countries, the incidence of urinary tuberculosis remained stable during the period 1957-1974, whereas a sharp fall in pulmonary tuberculosis was observable. the radiologic and bacteriologic findings in 125 cases personally observed over the last 18 years are presented. | 1977 | 412249 |
[fluorescence microscopy in the diagnosis of tuberculosis]. | | 1977 | 412292 |
[in-vitro effect of tobramycin]. | | 1977 | 412333 |
evaluation of some standard arthritogenic adjuvants ('modified perrigens') in male rats. | four commercially available arthritogenic adjuvants ('modified perrigens') were compared with a mycobacterium butyricum-mineral oil adjuvant for their ability to induce arthritis in male holtzman rats. the induced arthritides were also compared with respect to their response to treatment with phenylbutazone and cyclophosphamide. trivial differences were noted among the various adjuvants in their capability to induce the disease, the severity of the disease, or the response of the disease to ther ... | 1977 | 412400 |
primary sensitization potentials of some halogenated salicylanilides and their cross-sensitivity in guinea-pigs. | | 1977 | 412760 |
an examination of the effect of three phenolic disinfectants on mycobacterium tuberculosis. | | 1977 | 412826 |
lysosomal enzyme release in the isolated perfused heart of immunized rats. | | 1977 | 412979 |
[new pyridazine derivatives with physiological activities]. | | 1977 | 413176 |
experience with a tuberculosis antigen test in rhodesia. | experience with a new serological method for the diagnosis of tuberculosis is reported in a predominantly black population. we have found that in only 69% of 167 patients was there agreement between serology and the presence or absence of tuberculosis. both false positive and false negative results were common. of 47 healthy controls, 80% were positive. these results are less satisfactory than previous studies but differences in the reading of the results seems an unlikely explanation. differenc ... | 1977 | 413207 |
methods and medium for the culture of tubercle bacilli. | a brief account is given of methods recommended for the culture of tubercle bacilli and improved media are described appropriate for each. the chief changes suggested are reductions in the phosphate and dye content of media previously devised for alkaline inocula. | 1977 | 413228 |
[on the possibility of a rapid method for sensitivity testing of mycobacteria by determination of h3-uracil incorporation (author's transl)]. | dubos-tween albumin cultures (8.0 ml) were set up with 10(6) viable bacteria per ml. after incubation for 48 hours 0.25 muc h3-uracil per ml was added. at the same time the antituberculoticum was introduced. the final concentrations were 1 microgram, 0.25 microgram and 0.025 microgram for inh; 4.0 microgram for sm; 32 microgram and 0.32 microgram for rmp; 2.0 microgram and 1.0 microgram for eth; 0.5 microgram and 0.25 microgram for pas. the incorporation rate clearly depended on the degree of se ... | 1977 | 413283 |
[results of cultures of menstrual blood; looking for koch bacillus]. | | 1977 | 413328 |
[evaluation criteria of antitubercular drugs from microbiological view]. | in the years from 1954 to 74 sensitivity tests with about 12 000 strains of tubercle bacilli isolated from patients have been performed by the serial dilution method. from the results of the tests shown in the table one can see a remarkable shift in the frequency of strains sensitive against the so-called major drugs streptomycin and inh, whereas only slight variations have occurred with the recent drugs ethambutol and rifampicin. the well known change of clinic and epidemiology of tuberculosis ... | 1977 | 413337 |
experimental allergic encephalomyelitis. identification of the myelin component responsible for the appearance of brain esterified cholesterol. | | 1978 | 413746 |
structural and immunochemical studies on d-arabino-d-mannans and d-mannans of mycobacterium tuberculosis and other mycobacterium species. | serologically active d-arabino-d-mannas ([alpha]d, +82 degrees approximately 89 degrees; ratio of d-arabinose to d-mannose, 1-2:1) were isolated from the soluble fraction of disintegrated cells of m. tuberculosis, m. smegmatis, and several other mycobacterium species. these arabinomannans had similar structures, consisting of alpha-(1 leads to 5)-linked d-arabinose residues and alpha-(1 leads to 6)-, and (1 leads to 2)-linked d-mannose residues. methylation and enzymic degradation studies using ... | 1977 | 413830 |
leprosy and the serodiagnostic test for tuberculosis. | sera from patients with leprosy agglutinated killed h37rv mycobacterium tuberculosis to varying degrees. higher titres were found in association with active disease but there was no difference between patients at the lepromatous or at the tuberculoid ends of the clinical scale. a sharp rise in titre occurred during the active phase of an episode of erythema nodosum leprosum. | 1977 | 413841 |
sequential computerized axial tomography in tuberculous meningitis. | | 1978 | 413943 |
[studies on the relationship between the proliferation rate of infecting tubercle bacilli and the effectiveness of chemotherapy. ii. observations in various types of infection experiment (author's transl)]. | | 1977 | 414001 |
[drug sensitivity of tubercle bacilli to ethambutol and rifampicin determined by the canetti proportional method]. | | 1977 | 414214 |
[use of bacteriological method in tuberculosis control programs]. | | 1977 | 414351 |
nursery exposure of 528 newborns to a nurse with pulmonary tuberculosis. | newborn infants are thought to be particularly susceptible to infection with mycobacterium tuberculosis, and the possibility of exposure to unrecognized clinical tuberculosis in nursery and hospital personnel is ever present. to reduce this possibility, periodic skin testing of hospital personnel is often carried out, and tuberculin-positive personnel are given preventive treatment with isoniazid (inh). also, environmental controls, such as ultraviolet light and periodic air exchange, are used. ... | 1978 | 414362 |
the extent and importance of sensitization by opportunist mycobacteria in lagos, nigeria. | 3505 school children aged 6 to 15 years were tested with ppds and at the same time one of the following tuberculins, namely, ppdg, ppdpl, ppda, ppdf and ppdy. the tuberculins were prepared from human tubercle bacillus, the gause organism, m. marinum, m. avium, m. fortuitum and m. kansasii respectively. ppdy, ppda and ppdg gave more reactions of greater than 2 mm induration than did ppds. furthermore, tests with ppdy, ppda, ppdg and ppdpl showed a significant proportion of children with reactions ... | 1977 | 414397 |
comparison of strains of mycobacterium tuberculosis from british, ugandan and asian immigrant patients: a study in bacteriophage typing, susceptibility to hydrogen peroxide and sensitivity to thiophen-2-carbonic acid hydrazide. | strains of mycobacterium tuberculosis were obtained from 65 patients with pulmonary tuberculosis resident in uganda, and from pulmonary and extrapulmonary tuberculosis in 42 british patients of european ethnic stock and in 67 asian immigrants, often from uganda, resident in britain. the bacteriophage-type patterns of the african, british and asian strains were different. the pattern for the asian strains resembled that found previously in patients from south india, suggesting that there has been ... | 1977 | 414398 |
accidental self-inoculation with killed mycobacterium tuberculosis in freund's complete adjuvant. | the case is described of a laboratory worker who was carrying out an animal immunological experiment and accidentally punctured the palm of his hand with freund's complete adjuvant which contained heat-killed m. tuberculosis in a paraffin emulsion. a serious localised chronic tuberculoid granulomatous reaction developed which persisted for nine months. the significance of this phenomenon is discussed and the importance of the prevention of such an occurrence is emphasized. | 1977 | 414399 |
[an investigation of a newly isolated oligopeptide from mycobacterium tuberculosis with antigenic properties specific for the diagnosis of tuberculosis (author's transl)]. | | 1977 | 414482 |
infection of clethrionomys g. glareolus schreb. (red mice) with mycobacterium tuberculosis and mycobacterium bovis injected subcutaneously. | groups of red mice were injected with doses from 10 mg to 10(-8) mg semidried culture of a strain of m. tuberculosis and with doses from 10(-1) to 10(-8) mg of a strain of m. bovis. some animals were killed about 1 1/2 and 3 months after injection and the remainder lived until death occurred spontaneously. the number of tubercle bacilli in the organs was evaluated by microscopy of smears, in some cases by quantitative culture. among the mice injected with m. tuberculosis in doses of up to about ... | 1977 | 414516 |
the binding of adjuvant-active mycobacterial peptidoglycolipids and glycopeptides to mammalian membranes and their effect on artificial lipid bilayers. | the nature of the binding of adjuvant-active amphiphilic mycobacterial peptidoglycolipids and glycopeptides to mammalian plasma membranes was investigated together with their effect on the stability of artificial lipid bilayers. the importance of these interactions between mycobacterial components and membranes is discussed in relation to immunopotentiation, mitogenicity and tuberculous infection. | 1978 | 414992 |
effect of metabolic inhibitors on the formation of antibody to sheep erythrocytes, on development of delayed hypersensitivity, and on the immune response to infection with mycobacterium tuberculosis in mice. | the effect of a number of metabolic inhibitors was determined on: (i) the production of cellular immunity to infection with mycobacterium tuberculosis in mice by vaccination with mycobacterial ribonucleic acid (rna), (ii) the production of cellular immunity to infection with m. tuberculosis in mice with viable h37ra cells, (iii) the induction of antibody formation to sheep erythrocytes, and (iv) the induction of delayed hypersensitivity in mice to purified protein derivative. the pattern of inhi ... | 1978 | 415003 |
induction of cell-mediated immunity to mycobacterium leprae in mice. | the immune response of mice to armadillo-derived, irradiation-killed mycobacterium leprae (i-ml) was investigated. following injection of 100 microgram of i-ml into the left hind footpads of mice, a state of cell-mediated immunity (cmi) was engendered to antigens of m. leprae. the evidence for cmi was as follows: (i) development of delayed-type hypersensitivity to both human tuberculin purified protein derivative and soluble m. leprae antigens; (ii) t-lymphocyte-dependent macrophage activation a ... | 1978 | 415009 |
[nonspecific infection in patients with tuberculosis of the urinary tract during antibiotic therapy]. | | 1977 | 415177 |
[experience with the bacteriological diagnosis of pulmonary tuberculosis]. | | 1978 | 415431 |
infection of clethrionomys g. glareolus schreb. (red mice) with mycobacterium tuberculosis and mycobacterium bovis injected intraperitoneally. | | 1977 | 415511 |
infection of clethrionomys g. glareolus schred. (red mice) with mycobacterium tuberculosis injected intravenously. | | 1977 | 415512 |
the isolation by immunoabsorbent affinity chromatography and physicochemical characterization of mycobacterium tuberculosis antigen 5. | mycobacterium tuberculosis antigen 5 was purified from unheated culture filtrates by absorption onto an immunoabsorbent prepared with globulin from a monospecific goat antiserum and elution with 4.0 m urea at ph 9.0. the product was a homogeneous protein giving a single stainable band in acrylamide gel electrophoresis and a single precipitin arc in immunoelectrophoresis. it was found to have a molecular weight of 28,500 to 35,000 daltons and a sedimentation constant of 2.0. amino acid analysis d ... | 1978 | 415649 |
drug resistance among mycobacterium tuberculosis strains isolated in taiwan during 1975. | 455 strains of mycobacterium tuberculosis were isolated from patients with history of treatment in taiwan provincial tuberculosis control bureau and tested for resistance against various antituberculosis agents including streptomycin (sm), paraaminosalicylic acid (pas), isoniazid (inh), cycloserine (cs), prothionamide (1321th), kanamycin (km), ethambutol (emb), and rifampicin (rfp). in vitro resistance to sm and inh was more frequently found than others and the resistance to a single drug was mo ... | 1977 | 415848 |
utility of pyruvate medium for isolation of m. bovis and m. tuberculosis resistant to inh. | | 1977 | 415971 |
[mycobacterium tuberculosis sensitivity to nonspecific antibiotics]. | | 1978 | 416324 |
[bacterial isolation during chemotherapy of patients with pulmonary tuberculosis]. | | 1977 | 416433 |
[use of paper indicators for the identification of mycobacteria]. | | 1977 | 416434 |
[primary drug resistance in pulmonary tuberculosis (from 1966 till 1975 (author's transl)]. | | 1977 | 416450 |
impact of anti-tuberculosis legislation in libya on the prevalence of primary and acquired resistance to the three main drugs at a majortuberculosis centre. | the effect of legislative actions taken in 1973 on the prevalence of primary and acquired drug resistance was studied from the records on the regional tuberculosis and chest diseases centre in benghazi during the period june 1971 to august 1976. there were available for analysis 771 culture-positive cases of newly diagnosed pulmonary tuberculosis in libyan nationals, and 789 cases of both libyan nationals and others with positive cultures during treatment. the legislative actions included screen ... | 1978 | 416530 |
thrombocytosis and platelet aggregates in the circulation of adjuvant arthritic rats. | a marked increase in platelet count was observed in adjuvant-induced polyarthritic rats. elevation of platelet count was still significant 3 months after onset of disease. increased number and larger size of platelets reflect an increase in the rate of platelet production. by means of the platelet-count ratio technique, circulating platelet aggregates were demonstrated in rats with severe arthritis. aspirin treatment prevented thrombocytosis and formation of platelet aggregates. | 1978 | 416828 |
[relationship of the tuberculostatic activity of bis-benzylisoquinoline alkaloids to their structure]. | | 1978 | 416971 |
suppression of autochthonous tumors by mixed implantation with nocardia rubra cell-wall skeleton and related bacterial fractions. | antitumor activities of the cell-wall skeleton of nocardia rubra and related bacterial fractions in autochthonous tumor-host system were tested on autografts of spontaneous mammary adenocarcinoma in shn mice and of 3-methylcholanthrene-induced fibrosarcoma in icr/jcl mice. the oil-attached cell-wall skeleton of n. rubra was the most effective in suppressing the autografts of the mammary adenocarcinoma but less of the fibrosarcoma, when the autografts were mixed with oil-attached preparation and ... | 1978 | 416987 |
suppression of delayed hypersensitivity to the hapten by induction of tolerance to the carrier. | delayed hypersensitivity reactions (dhr) and anaphylactic reactions to carrier and hapten determinants were studied in guinea pigs immunized with dnp-mycobacterium and rendered partially tolerant to the carrier by a single intravenous injection of mycobacterium prior to immunization. the results clearly show that the induction of depressed dhr to mycobacterium leads to a suppression of dhr to the hapten while no depression of anaphylaxis to the hapten is observed. it is proposed that the tolerog ... | 1978 | 417034 |
[changes in tuberculosis]. | | 1978 | 417040 |
studies on synthesis of coumarin derivatives. xxvi. tuberculostatic activities and solubilities of 3-sulfonamido- and 3-carboxamido-coumarins. | | 1977 | 417214 |
studies on pyrazine derivatives. part xiii. synthesis and tuberculostatic activity of some 6-alkyl-amino- and 6-dialkylhydrazinopyrazine-2-carboxylic acids derivatives. | 6-rnh- and 6-r2nnh-pyrazine-2-carbothioamides 1--3, 5, 6, 9 and 14 were obtained from 2-cyano-6-chloropyrazine. in the in vitro screening the thioamides were active against myc. tuber. h37rv at the conc. range of 15.6--250 microgram/cm3. the most active thioamides 1 and 8, however, do not act in experimental tuberculosis in guinea pigs. | 1978 | 417305 |
tuberculosis and mediastinoscopy. | biopsy of lymph nodes at mediastinoscopy has been the method of diagnosis of tuberculosis in 14 patients; mycobacterium tuberculosis was cultured from the nodes in nine cases, and in five there was histological evidence of the disease but cultural confirmation was lacking. all patients had radiographic abnormality of the superior mediastinum, and a frequent finding at mediastinoscopy was mediastinal fibrosis involving the fascia and lymph nodes. no cause other than tuberculosis could be demonstr ... | 1978 | 417418 |
[analytical study of mycobacterium tuberculosis resistance in the sfax region (hôpital hédi chaker and farhat hached dispensary during 1973, 1974 and 1975]. | | 1977 | 417442 |
[synthesis of various derivatives of 3-aminopyrazine-2-carboxylic acid]. | | 1977 | 417558 |
rapid radiometric susceptibility testing of mycobacterium tuberculosis. | a 48-hour radiometric test for determining the drug susceptibility of mycobacterium tuberculosis has been developed. the test is based on the measurement of 14co2 produced by the oxidation of formate labeled with carbon-14. the test system uses 5 x 10(7) organisms in 1 ml of middlebrook 7h9 medium plus albumin-dextrose-catalase enrichment and 1 muci of [14c]formate. the 14co2 produced is measured in an ionization chamber at 24-, 48-, and 72-hour intervals, with and without the addition of antitu ... | 1978 | 417650 |
[development of indices of bacterial resistance against tuberculosis bacteria in the argentinian republic]. | | 1977 | 417693 |
[primary resistance of mycobacterium tuberculosis (studies related to the triennium 1973-6)]. | | 1977 | 417694 |
[development of primary resistance of mycobacterium tuberculosis in the last 5 years (1970-1976)]. | | 1977 | 417695 |
[effect of surface-active agents on mycobacterium tuberculosis and mycobacterium bovis. obtaining chromogenic mycobacteria]. | in 18 strains of m. tuberculosis and m. bovis it has been possible to demonstrate the existence, in pure cultures, of elements able to grow in vitro in scotochromogenic mycobacteria. the experimental method used includes a dispersion, under shaking, of organisms in different surface-active agents. the chromogenic strains isolated during the experimentation are eugonic, and pas- and inh-resistant. their experimental virulence is different from that of tubercle bacillus. we discuss the significati ... | 1978 | 417788 |
genetic transfers in mycobacteria. | | 1978 | 417980 |
the sensitization of children by opportunist mycobacteria in lagos, nigeria. | groups of school children aged 6-14 years were tested with ppds and one of the following five antigens simultaneously, namely ppda, ppdf, ppdg, ppdpl and ppdy, ppds was prepared from the human tubercle bacillus, and the others were prepared from m. avium, m. fortuitum, the 'gause' organisms, m. marinum and m. kansasii respectively. it was observed that there was some increase in induration size to ppda, ppdg, ppdl, ppds and ppdy with increase in age, while m. fortuitum gave a preponderance of sm ... | 1978 | 418112 |
nursing care study: spontaneous pneumothorax. | | 1978 | 418385 |
[influence of high doses of isoniazid on mycobacterium tuberculosis]. | | 1978 | 418399 |
[dynamics of l-form mycobacteria excretion in the treatment of patients with newly diagnosed destructive pulmonary tuberculosis]. | | 1978 | 418400 |
[use of immunofluorescent method in the identification of mycobacteria]. | | 1978 | 418401 |
[modification of kalfin's method of growing m. tuberculosis]. | | 1978 | 418402 |
[influence of deoxyribonuclease and ribonuclease on the growth and drug resistance of m. tuberculosis]. | | 1978 | 418403 |
[effect of flower honey and its products on the m. tuberculosis]. | | 1978 | 418404 |
[primary chemoresistance to tuberculostatics in the district of dolj between the years 1971 and 1975]. | primary resistance to tuberculostatics between 1971 and 1975 was studied in a lot of 676 adults with pulmonary tuberculosis, as well as the incidence and overall prevalence of primary and secondary resistance within the district covered by the tb. dispensary of craiova. the incidence of primary resistance was of 13,61% of the entire lot, falling from 20.41% in 1971--1972, to 14.28% in 1973--1974 and to 7.25% in 1975. the incidence fell from 6.66 per 100 000 in 1971 to 2.3 per 100 000 in 1975, an ... | 1978 | 418488 |
[bacteriologic findings in childhood tuberculosis]. | | 1977 | 418543 |
[atypical mycobacteria and their pathogenicity for agricultural animals]. | | 1978 | 418560 |
application of bacteriophage typing to studies on the epidemiology of tuberculosis in asian immigrants resident in great britain. | | 1978 | 418715 |
mycobacteriophages and phage typing. | | 1978 | 418716 |
therapeutic effect of prolonged hyperbaric oxygen in adjuvant arthritis of the rat. | development of adjuvant disease in the rat is suppressed if hyperbaric oxygen is administered within one day after the inoculation of an oil suspension of mycobacterium tuberculosis and continued for 16 to 17 days. although 10 to 40% of the rodents developed mild arthritis after discontinuance of therapy, most remained symptom-free for at least 50 days. oxygen administered after arthritis is advanced still exerted a significant curative effect. possible mechanisms underlying the therapeutic acti ... | 1979 | 426880 |
preservation of mycobacteria at -70 degrees c: survival of unfrozen suspensions in transit. | mycobacteria stored at -70 degrees c retain 100% viability and maintain their definitive taxonomic, serologic, immunologic, and pathogenic properties. when shipped at ambient temperatures, however, suspensions of all mycobacteria lose viability in transit, with those species having a narrow temperature range for growth (mycobacterium tuberculosis and m. bovis) being most severely affected. in spite of these losses, all strains retain their definitive taxonomic properties. if care is taken in pre ... | 1979 | 452120 |
a cluster of mycobacterium gordonae isolates from bronchoscopy specimens. | during a 2.5-year period, 52 patients at yale-new haven hospital had mycobacterium gordonae recovered from specimens obtained by suction at bronchoscopy; 2 of them also had smears positive for acid-fast bacilli. almost all of the isolates came from patients bronchoscoped by the same physician, one of 4 who performed the procedure during that period. only this physician added one drop of green dye, stored in a 100-ml bottle, to the cocaine used for topical anesthesia during the procedure; culture ... | 1979 | 464382 |
tuberculin test conversion during repeated skin testing, associated with sensitivity to nontuberculous mycobacteria. | to determine whether repeating the tuberculin test after a brief interval might result in tuberculin conversion, we tested 213 healthy volunteers twice, 1 month apart, with 5 tu of tuberculin purified protein derivative (ppd). three nontuberculous mycobacterial antigens (ppd-g, ppd-y, and ppd-b) were also applied with the first tuberculin test. by widely used criteria, 14 volunteers (6.6 per cent) converted their tuberculin tests from negative to positive on the second testing. whereas 13 of 103 ... | 1979 | 464385 |
recurrent miliary tuberculosis secondary to infected ventriculoatrial shunt. | the placing of a ventriculoatrial anastomosis because of elevated csf pressure secondary to tuberculous meningitis resulted in repeated dissemination of mycobacterium tuberculosis from the anastomosis. the consequent clinical picture showed recurrent appearance and clearing of miliary tuberculosis of the lung in spite of antituberculosis chemotherapy. while this possibility was considered early, the diagnosis was not established until the shunt was replaced shortly before the patient's death. | 1979 | 467121 |
infective pericarditis in nigerian children. | 53 children with infective pericarditis were seen at the university college hospital, ibadan, between 1967 and 1976. their ages ranged from 10 days to 15 years but 53% of them were aged 5 years and below. cough, fever, and breathlessness were the most common symptoms; cardiac decompensation was evident in over 30% of them, 23% had muffled heart sounds, but a pericardial friction rub was audible in only one. the main pathogens identified were mycobacterium tuberculosis (11 cases), staphylococcus ... | 1979 | 475415 |
listeria pneumonitis: influence of route of immunization on resistance to airborne infection. | mice that are immunized with an airborne inoculum of bcg are more highly resistant to airborne challenge with mycobacterium tuberculosis than are mice that are immunized by the subcutaneous or intravenous route. to discover whether this phenomenon is peculiar to tuberculosis, we studied the influence of the route of immunization upon pulmonary resistance in listeria monocytogenes infection. mice were immunized by the airborne, intravenous, or footpad route and were subsequently challenged by the ... | 1979 | 489125 |
[tuberculous cerebral abscess. morphopathologic study (author's transl)]. | a 73-year-old patient with a cerebral abscess of tuberculous etiology localized in the left parietooccipital region is presented. clinically it had behaved like an expansive process. the inside of the abscess contained a purulent exudate with polynuclear cells and necrotic material. the wall of the abscess was formed by a predominantly histiocytic internal layer and an external one composed by histiocytes with the morphology of epithelioid cells. no tuberculous granulomas were found. the histioc ... | 1979 | 491787 |
hla-bw15 and tuberculosis in a north american black population. | peripheral blood lymphocytes from 60 black patients with mycobacterium tuberculosis disease proved by culture and 100 healthy black persons were hla phenotyped using a standard lymphocytotoxicity test. statistical analysis of the results showed that only bw15 antigen had a significantly increased frequency among patients with tuberculosis when they were compared to healthy persons. furthermore, examination of disease manifestations among patients with tuberculosis demonstrated that patients with ... | 1979 | 517859 |
experimental granulomatous inflammation: ii. effect of injection of intact and disrupted killed tubercle bacilli into freund adjuvant-sensitized cavies. | the reaction of freund adjuvant-immunized cavies to subsequent injection of mycobacterium tuberculosis h37ra is confirmed as an immunologically mediated phenomenon. ultrasonic disruption of mycobacteria to be injected as "challenge" markedly increases the intensity of the consequent 24-48 h reaction and subsequent fibrosis in freund adjuvant-sensitized cavies and has an apparently inhibiting effect on the extent of subsequent granuloma formation with marked reduction of the density of epithelioi ... | 1979 | 523183 |
a serological comparison of pasteurella haemolytica vaccines containing different adjuvants. | five adjuvants were compared for their ability to enhance the serological response of sheep to capsule extract of pasteurella haemolytica biotype a serotype 6. vaccines of this antigen were inoculated with incomplete freund's adjuvant, complete freund's adjuvant, incomplete freund's adjuvant containing a water soluble extract of mycobacterium tuberculosis, aluminium hydroxide gel or a combination of aluminium hydroxide gel and incomplete freund's adjuvant. this latter vaccine induced significant ... | 1979 | 523817 |
granulomatous synovitis: the role of atypical mycobacteria. | clinical data on 25 patients with granulomatous synovitis and bursitis observed from 1970 through 1977 are reviewed. the lesions occurred about the extremities, the wrists and hands being involved most often. with three exceptions, the patients had no significant underlying disease. the lesions were chronic and often followed minor trauma. many patients had had prior surgery, steriod injections, or both. at the time of surgery for the synovitis, the gross appearance proved to be relatively chara ... | 1979 | 542760 |
photochromogenic and scotochromogenic mycobacteria: their clinical significance. | in the period 1973--1977, mycobacterium tuberculosis was isolated by cultivation in 4408 cases from the clinical specimens of patients with positive x-ray findings. on the basis of atypical colony morphology or pigment formation, 263 other mycobacterial strains were identified: of these 23 were photochromogenic and belonged to mycobacterium kansasii. the strains were cultured on several occasions from the specimens of 4 patients with broncho-pulmonary mycobacteriosis. the strains were resistant ... | 1979 | 543456 |
tuberculosis of the tongue. | involvement of the tongue by mycobacterium tuberculosis occurs on rare occasions. two interesting cases of tuberculosis of the tongue are reported and the mode of transfer of mycobacterium tuberculosis to oral tissues is discussed. the need to consider tuberculosis as an etiological factor in indolent oral lesions is emphasised. | 1979 | 547862 |