| trypanosoma cruzi: uptake and intracellular fate in normal and activated cells. | | 1977 | 413447 |
| specific and non-specific immunity to haemoprotozoa. | | 1977 | 413449 |
| [studies on the relationship between the proliferation rate of infecting tubercle bacilli and the effectiveness of chemotherapy. ii. observations in various types of infection experiment (author's transl)]. | | 1977 | 414001 |
| infection of clethrionomys g. glareolus schreb. (red mice) with mycobacterium tuberculosis and mycobacterium bovis injected subcutaneously. | groups of red mice were injected with doses from 10 mg to 10(-8) mg semidried culture of a strain of m. tuberculosis and with doses from 10(-1) to 10(-8) mg of a strain of m. bovis. some animals were killed about 1 1/2 and 3 months after injection and the remainder lived until death occurred spontaneously. the number of tubercle bacilli in the organs was evaluated by microscopy of smears, in some cases by quantitative culture. among the mice injected with m. tuberculosis in doses of up to about ... | 1977 | 414516 |
| infection of clethrionomys g. glareolus schreb. (red mice) with mycobacterium tuberculosis and mycobacterium bovis injected intraperitoneally. | | 1977 | 415511 |
| utility of pyruvate medium for isolation of m. bovis and m. tuberculosis resistant to inh. | | 1977 | 415971 |
| [use of paper indicators for the identification of mycobacteria]. | | 1977 | 416434 |
| suppression of autochthonous tumors by mixed implantation with nocardia rubra cell-wall skeleton and related bacterial fractions. | antitumor activities of the cell-wall skeleton of nocardia rubra and related bacterial fractions in autochthonous tumor-host system were tested on autografts of spontaneous mammary adenocarcinoma in shn mice and of 3-methylcholanthrene-induced fibrosarcoma in icr/jcl mice. the oil-attached cell-wall skeleton of n. rubra was the most effective in suppressing the autografts of the mammary adenocarcinoma but less of the fibrosarcoma, when the autografts were mixed with oil-attached preparation and ... | 1978 | 416987 |
| in vitro lymphocyte transformation as a herd survey method for bovine paratuberculosis. | the lymphocyte-transformation (lt) test was evaluated for its potential application as a field test for bovine paratuberculosis. using a whole blood technique, samples from 3 consecutive collection periods were subjected to 3 mycobacterial antigens and to phytohemagglutinin. the results obtained from lt were compared with conventional serologic and cultural methods. a positive lt response to johnin purified-protein derivative (ppd) or avian ppd (or both) was noted in 40% to 60% of the animals te ... | 1978 | 417649 |
| [effect of surface-active agents on mycobacterium tuberculosis and mycobacterium bovis. obtaining chromogenic mycobacteria]. | in 18 strains of m. tuberculosis and m. bovis it has been possible to demonstrate the existence, in pure cultures, of elements able to grow in vitro in scotochromogenic mycobacteria. the experimental method used includes a dispersion, under shaking, of organisms in different surface-active agents. the chromogenic strains isolated during the experimentation are eugonic, and pas- and inh-resistant. their experimental virulence is different from that of tubercle bacillus. we discuss the significati ... | 1978 | 417788 |
| [hla phenotypes in patients surviving a long time after immunotherapy with bcg for acute childhood lymphoblastic leukemia. arguments in favor of the existance of a gene for immune response in human leukemia]. | hla phenotypes of 13 patients surviving in lasting first remission over 6 years after bcg immunotherapy for acute childhood lymphoblastic leukaemia (all) were compared to phenotypes of normal subjects and of surviving all patients treated exclusively with chemotherapy. among the bcg-treated patients, the frequency of the antigen hla-bw 17 was 46.1% vs 7.3% in healthy controls (p less than 0.001) and the frequency of the antigen hla-aw 33 was 30.8% vs 1.2% (p less than 0.001). 9 patients possesse ... | 1977 | 417839 |
| [potentiation of immunologic memory by corynebacterium parvum and its mechanism]. | immune response to bovine serum albumin (bsa) at dose of 2,50 mg/kg which is rather a weak immunogen in rabbits, when given intravenous was highly potentiated when the animals received a previous single intravenous infection of 2 mg/kg of c. parvum, followed by subsequent bsa anamnestic challenges for several months. thus, the antibody amounts synthesized following the 1st anamnestic injection (3 weeks) were 0,260 mg/ml in the control versus, 0,800 mg/ml in the c. parvum pretreated groups; follo ... | 1977 | 417841 |
| genetic transfers in mycobacteria. | | 1978 | 417980 |
| [atypical mycobacteria and their pathogenicity for agricultural animals]. | | 1978 | 418560 |
| laboratory-acquired infections at the national animal disease center 1960--1976. | experience with exposure to, or infection with pathogenic agents at the national animal disease center is summarized. a total of 60 laboratory-associated exposures to infectious disease agents were reported. forty-nine exposures resulted from known accidents, but the other 11 were identified only after the development of clinical or serological manifestations of infection. eighteen cases of laboratory-acquired infections were reviewed. brucellosis, the most frequently reported laboratory-acquire ... | 1978 | 565343 |
| in vitro stimulation of bovine peripheral blood lymphocytes: effect of short-term storage of blood prior to lymphocyte culture. | storage of peripheral blood from mycobacterium bovis-sensitized cattle from 1 to 48 hours at 4, 22, and 37 c was shown not to alter markedly the lymphocyte blastogenic response to m bovis-purified protein derivative. concanavalin a-induced lymphocyte mitogenic responses were unaffected by storage of blood for 1, 24, or 48 hours at 22 c and 37 c; however, storage of blood for 48 hours at 4 c significantly lowered (p less than 0.05) mitogenic responses to concanavalin a, as compared with responses ... | 1978 | 629471 |
| in vitro stimulation of bovine peripheral blood lymphocytes: comparison of round- and flat-bottom microtiter plates for detection of tuberculin hypersensitivity. | lymphocytes from mycobacterium bovis-sensitized and normal cattle were cultured in round- and/or flat-bottom microtiter plates and stimulated with m. bovis purified protein derivative (ppd) tuberculin. blastogenic responses of lymphocytes from m. bovis-sensitized cattle to ppd cultured in round-bottom plates were significantly greater than those of lymphocytes cultured in flat-bottom microtiter plates. normal lymphocytes of nonsensitized cattle were not stimulated by ppd in either round- or flat ... | 1978 | 632347 |
| immunotherapy of bilateral lymph node metastases in guinea pigs by intralesional or paralesional injection of mycobacterium bovis (bcg). | bilateral axillary lymph node metastases occurred after intradermal (id) injection of line 10 hepatocellular carcinoma cells over the thoracic spine of inbred guinea pigs. excision of the dermal tumor 7 days after injection of tumor cells did not prevent the development of metastases. injection of bcg into dermal tumors without surgery led to their regression and prevented the growth of microscopic metastases in both right and left superficial distal axillary lymph nodes. bilateral id injection ... | 1978 | 642033 |
| proceedings: role of immunocompetence in localized bcg suppression of tumour growth. | | 1975 | 764845 |
| proceedings: active immunotherapy in acute myeloid leukaemia. | | 1975 | 764846 |
| granulocyte function in myeloblastic leukaemia. | a study of granulocyte function in myeloblastic leukaemia is reported. function was assessed by the ability of peripheral blood granulocytes to ingest and kill candida albicans in bitro. depressed cidal activity was observed in 11 patients with smouldering leukaemia and in 19 patients with acute myeloid leukaemia. cidal activity was lowest in the untreated acute disease; this improved during cytoreduction therapy and was maintained when remission occurred. leukaemic plasma depressed the function ... | 1975 | 764849 |
| granulomatous hepatitis caused by b.c.g. injection during immunotherapy of a malignant melanoma. | the authors report a case of granulomatous hepatitis after treatment by b.c.g. in a patient with malignant melanoma. the patient was treated for one year by an association of chemotherapy and lyophilized b.c.g. (pasteur institute). aside from the rarity of the localization the importance of this observation resides in the discovery of b.c.g. after auramine staining in the liver suggesting that the hepatic lesions were linked to the in situ presence of mycobacteria. | 1975 | 764894 |
| mechanisms of protective immunity in experimental cutaneous leishmaniasis of the guinea-pig. ii. selective destruction of different leishmania species in activated guinea-pig and mouse macrophages. | macrophages activation as the effector mechanism in destroying l. enriettii in the guinea-pig, and l. tropica in the mouse, was tested in vitro. activated guinea-pig macrophages, with enhanced anti-listeria capacity had no effect on the survival of intracellular l. enriettii, irrespective of the antigen used. activated mouse macrophages, on the other hand, destroyed ingested l. enriettii within 24-48 hr but had no effect on l. tropica during the same time period. it is suggested that the pathoge ... | 1975 | 765014 |
| inflammatory factors produced by sensitized guinea-pig peripheral blood lymphocytes. | the supernatants obtained from stimulated tuberculin-sensitive guinea-pig peripheral blood lymphocytes contain factors that induce a cutaneous inflammatory response in normal guinea-pigs similar to the tuberculin reaction and inhibit the migration of normal guinea-pigs peritoneal exudate cells. there appears to be a correlation between the presence of in vitro migration inhibitory activity and inflammatory activity in vivo. | 1976 | 765143 |
| [immunological changes of splenic cells in bcg infected mice]. | | 1975 | 765554 |
| [virulence of bcg and induction of cellular immunity (2)]. | | 1975 | 765561 |
| [antigenic analysis of the structural components of the surface of bcg cells]. | | 1975 | 765574 |
| [the 50th annual meeting symposium. ii. persepctive review of 50 years experiences on clinical and epidemiological research. part 1. bcg (author's transl)]. | | 1975 | 765597 |
| protection of mice against babesia and plasmodium with bcg. | | 1976 | 765838 |
| review and new proposals for immunotherapy of brain tumors. | the authors give a review of the possibilities and new approaches of therapy of malignant brain tumors. | 1976 | 765879 |
| [viewpoints on the pharmacological suppression of immunologic reactivity]. | the pharmacological alteration of immunological reactivity is considered. the immunosuppressive drugs may be classified according to their chemical class and their antigen- or cycle-dependency. a relative specificity towards the lymphoid system is cyclophosphamide. new vistas are opened by the modulation of immunological reactivity by cyclic nucleotides. the possibilities afforded by the combined use of immunosuppressive drugs have not been fully exploited. a short therapeutic program including ... | 1975 | 766172 |
| asparaginase activity of bcg and its phenotypes in relation to culture phases. | the asparaginase activity of the montreal strain of bcg and of 2 of its phenotypes varies with the age of the culture; it starts to increase at the midlog phase of growth, reaches a maximum value near the end of this phase and decreases during the stationary or autolytic phase. however, the variations in this enzyme activity are greater in 2 the phenotypes than in the parental bcg. | 1975 | 766691 |
| serum lysozyme as a marker of host resistance. i. production by macrophages resident in rat sarcomata. | with progressive growth of syngeneic sarcomata in rats there was a rise in serum levels of lysozyme which correlated with their immunogenicity and their macrophage content. by an examination of lymph/blood differences in normal and in tumour bearing rats and of the production of lysozyme by cells obtained from the tumours and maintained in vitro, it is apparent that the macrophages resident in a tumour mass make a massive contribution to the elevation in serum lysozyme concentrations. tumour cel ... | 1976 | 766806 |
| proceedings: the effect of bacille calmette-guérin (bcg) and corynebacterium parvum on the development of spontaneous mouse mammary carcinoma. | | 1976 | 766891 |
| failure of bcg immunostimulation to affect the clinical course of burkitt's lymphoma. | a controlled randomised trial was carried out to evaluate the efficacy of bcg immunotherapy in preventing relapse in patients with burkitt's lymphoma in whom remission had been induced with cyclophosphamide. twenty-one patients were treated with bcg, and 19 were controls. eleven patients in each group relapsed during a follow-up period long enough to make it unlikely that further relapses would occur. there were no significant differences in the length of remission or the site of relapse that co ... | 1976 | 766905 |
| purification and characterization of tuberculin-active components from bcg. | the tuberculin activity of protoplasmic extracts isolated from living bcg was purified successively by gel filtration on sephadex g-100 and g-75, and by electrophoresis on 7.5% and on gradient (6-18%) polyacrylamide gels. the tuberculin-active fractions, as determined in bcg-sensitized guinea pigs, were used as the starting material for each of the following fractionation steps. the physicochemical properties and the antigenic activity of the biologically active fractions have shown that a singl ... | 1975 | 766930 |
| intralesional bcg in the treatment of metastatic malignant melanoma. | the therapeutic efficacy of intralesional bcg (bacillus calmette-guerin; one immunizing dose every 2 weeks for a minimum of five treatments) was studied in 19 melanoma patients. of 15 patients evaluable for response, five experienced significant objective improvement (two complete and three partial remissions). objective improvement was limited to those patients with dermal metastatic disease. in vitro cytotoxicity in the presence of patient's serum bore, on average, a relationship to the clinic ... | 1976 | 766947 |
| the second generation of eortc-ecig experimental screening for systemic immunity adjuvants. its significance for cancer immunotherapy. a comparison of bcg and its hydrosoluble extract. | | 1975 | 767112 |
| flow microfluorometric quantitation of the blastogenic response of lymphocytes. | a method for quantitating the specific stimulation of peripheral lymphocytes has been developed using the techniques of flow microfluorometry. peripheral bovine lymphocytes were collected and specifically stained for deoxyribonucleic acid (dna) content using a low-salt propidium iodide procedure. flow microfluorometry was used to determine, on the basis of dna content, the percentage of cells in a population that was stimulated. extremely uniform staining of the lymphocytes (coefficient of varia ... | 1976 | 768372 |
| changes in cell-mediated cytotoxicity during the clinical course of patients with bladder carcinoma. | the conventional cell-mediated cytotoxicity assay was modified so that more useful estimates of cell-mediated immunity to transitional cell carcimoma of the urinary tract could be obtained. with this modified assay changes in the levels of cell-mediated immunity in transitional cell carcinoma patients to transitional cell carcinoma target cells were measured during the clinical course. initial results from a small number of patients with invasive and non-invasive tumors showed that anti-transiti ... | 1976 | 768528 |
| isolation of a subpopulation of adherent peritoneal cells with anti-tumour activity. | | 1976 | 768773 |
| evidence for a soluble lymphocyte factor in the transplacental transmission of t-lymphocyte responses to mycobacterium leprae. | | 1976 | 768774 |
| [model of allergy of the immediate type to bcg and analysis of allergic reactivity in bcg vaccination in experiments]. | | 1975 | 768978 |
| turnover of tritiated-thymidine-labeled mononuclear cells in tuberculous lesions of rabbits: a comparison of primary dermal bcg lesions and those of reinfection. | rabbits were infected or reinfected intradermally in multiple sites with bcg. one day before the bcg infection they were injected iv with a single pulse of tritiated thymidine (3ht). at various times thereafter, the bcg lesions were biopsied and evaluated for 3ht-labeled mononuclear cells (mn), which are mostly macrophages but include some lymphocytes. periodically old tuberculin (ot) was infected intradermally, creating mn traps, which were biopsied and evaluated 1 day after their onset. these ... | 1976 | 768991 |
| tuberculosis in wild badgers (meles meles) in gloucestershire: pathology. | the gross and histological appearances of the lesions of tuberculosis in 36 wild badgers found to be infected with mycobacterium bovis are described. these badgers were examined over a period of two years during an investigation into the possible epidemiological association of tuberculosis in badgers and cattle. the possible significance of the lesions in transmission of m bovis to cattle and other badgers is discussed. the histological appearance of the lesions was considered to be indicative o ... | 1976 | 769293 |
| letter: badger translocations: a cruel kindness? | | 1976 | 769294 |
| a case of bovine tuberculosis in fallow deer. | | 1976 | 769300 |
| immunogenicity of a rat leukaemia of spontaneous origin (sal). | the sal rat leukaemia, which resembles acute myeloblastic leukaemia, appeared initially to be non-immunogenic since resistance to an i.p. challenge with as few as 100 cells could not be obtained using stimulation of the res or by immunization with sal cells exposed to x-rays, nitrogen mustard, iodoacetate or glutaraldehyde. however, immunization with sal cells exposed to low doses of mitomycin-c slowed the growth of the challenge inoculum. cells treated with high doses of mitomycin-c did not imm ... | 1976 | 769814 |
| specific release of neutrophillic- and eosinophilic-stimulating factors from sensitized lymphocytes. | mitogen-stimulated lymphocytes recently have been shown to release colony-stimulating activity (csa), a stimulator of granulopoiesis in vitro. whether csa release is a result of specific antigen-lymphocyte interactions has been investigated by determining the ability of spleen lymphocytes isolated from trichinella spiralis and bacille calmette guerin (bcg) infected mice to release csa. lymphocytes were incubated with different antigens to obtain conditioned media (cm). conditioned media prepared ... | 1976 | 769865 |
| radiation therapy and immunotherapy: the value of immunotherapy in the control of local and regional cancer. | | 1976 | 769945 |
| monitoring of immunologic status of patients receiving bcg therapy for malignant disease. | bcg immunotherapy in a standard regime was administered by scarification to 26 selected patients with controlled malignant disease, 14 with lung cancer and 12 with melanoma. all were followed for 12 months after the first bcg administration or until death. during the first 3 months, when bcg was given weekly, immune reactivity as determined by skin tests and in vitro lymphocyte responses to phytohemagglutinin and recall antigens was enhanced in all patients except those in whom recurrence or ext ... | 1976 | 769946 |
| the effect of mycobacterium bovis (bacillus calmette-guérin) on macrophage random migration, chemotaxis, and pinocytosis. | macrophage random migration, chemotactic responsiveness, and pinocytosis were studied in the guinea pig after bacillus calmette-guérin (bcg) administration. oil-induced peritoneal exudate cells were evaluated for random migration and chemotaxis in modified boyden chambers. pinocytosis was measured by the in vitro uptake of colloidal 198au. there was a parallel increase in random migration and chemotaxis after an i.p. dose of 1.0 x 10(7) colony-forming units of bcg. this was seen as early as day ... | 1976 | 769964 |
| surgical treatment of malignant melanoma. | surgery alone is incapable of curing most patients with malignant melanoma. wide local excision and skin grafting are the most important factors in the local treatment of malignant melanoma. regional lymph node dissection in selected patients with clinical stage i disease is useful in identifying those patients with positive lymph nodes suitable for studies of adjunctive treatments. studies of the role of bacillus calmette-guérin in the treatment of primary malignant melanoma and stage ii malign ... | 1976 | 769968 |
| bacillus calmette-guérin immunotherapy in combination with dtic (nsc-45388) for the treatment of malignant melanoma. | combination studies of immunotherapy and dtic chemotherapy for patients with malignant melanoma are described. at our institute the combination of bacillus calmette-guérin (bcg) with dtic, or dtic plus methyl-ccnu, has resulted in augmentation of remissions in areas regional to bcg immunization, prolongation of chemotherapy-induced remissions, and significant prolongation of survival compared to the use of dtic chemotherapy without immunotherapy. data from other centers have shown that augmentat ... | 1976 | 769970 |
| mitogenic and adjuvant activity of a methanol extraction residue (mer) of tubercle bacilli on mouse lymphoid cells in vitro. | the mitogenic and adjuvant effect in vitro of mer (methanol extracted residue of tubercle bacilli), on balb/c and nu/nu immunocompetent cells was examined and compared with the effect of ppd, lps, ds, pha and cona. mer activated dna synthesis in spleen cells of balb/c and nu/nu mice and in blood cultures of balb/c. the stimulation of dna synthesis by mer in spleen cells was not macrophage dependent. bone marrow and 1ymph node cells were slightly stimulated while thymus cells were not affected. b ... | 1975 | 770312 |
| cutaneous granulomatous response to bcg cell walls with reference to cancer immunotherapy. | a chronic inflammatory response produced by cell walls of mycobacterium bovis strain bcg associated with microscopic oil droplets (bcg cw-o) was studied with reference to the tumor-regressing ability of this preparation. when bcg cw-o was injected intradermally in the footpads of guinea pigs, intense inflammation developed at the site of injection and in the draining popliteal lymph node. this was characterized histologically as granulomatous inflammation. the intensity of the response was relat ... | 1976 | 770333 |
| restoration of t-cell responsiveness by thymosin: development of antituberculous resistance in bcg-infected animals. | t-cell-depleted (adult thymectomized, lethally irradiated, bone marrow-reconstituted [thxb]), sham-thymectomized (xb) and normal control mice were injected daily with 3 mg of calf thymosin for 16 days. on day 8 of the treatment, the mice, together with untreated controls, were infected intravenously with 4 x 10(6) viable mycobacterium bovis (bcg montreal). growth of the bcg in the lungs and spleens was compared quantitatively for up to 100 days. thymosin treatment reversed the progressive weight ... | 1976 | 770334 |
| transformation of lymphocytes in patients with malignancies after intralesional application of bcg. preliminary report. | | 1976 | 772124 |
| experimental mycobacterial infection in congenitally athymic "nude" mice. | | 1976 | 772204 |
| antigen-reactive cells to tumor antigens in normal and tumor patients. | | 1976 | 772313 |
| chemical and biological properties of hydrosoluble fraction of bcg. | | 1975 | 772805 |
| potency of purified tuberculin determined by the shock method on hamsters. | two lots of purified protein derivative of tuberculin with different potencies determined by skin tests on guinea pigs, were examined for their capacity to induce shock in hamsters sensitized with bcg. groups of hamsters were injected with varying doses of a highly potent strain of bcg grown in dubos fluid medium. 4-5 weeks later two groups of animals sensitized with corresponding doses were injected intraperitoneally with 1 mg of each lot of tuberculin. 12 of the 20 hamsters given the strong tu ... | 1976 | 773097 |
| fatal disseminated bcg infection. an investigation of the immunodeficiency. | a 2-year-old boy had a fatal disseminated bcg infection. immunologic assessment showed a normal humoral response and normal numbers of e rosettes, normal thymus weight and histological features, but an abnormal response of lymphocytes in vitro and negative skin tests. histological examination showed the presence of gram-negative acid-fast bacilli within the macrophages. the possible mechanisms of immunodeficiency in this patient are discussed. | 1976 | 773173 |
| mononuclear cell turnover in chronic inflammation: studies on tritiated thymidine-labeled cells in blood, tuberculin traps, and dermal bcg lesions of rabbits. | rabbits were injected intradermally in multiple sites with bcg. four days after the bcg injection, they were injected intravenously with a single pulse of tritiated thymidine (3h-tdr) at various times thereafter, the bcg lesions were biopsied and evaluated for 3h-tdr-labeled mononuclear cells (mn). periodically, old tuberculin (ot) was injected intradermally, creating mn traps which were biopsied and evaluated 1 day after their onset. 3h-tdr-labeled cells were also evaluated in samples of blood. ... | 1976 | 773192 |
| inhibition of transplanted sarcomas mediated by bcg in rats with a defined immunological deficit. | experiments were undertaken to test the hypothesis that a major component of bcg contact-induced inhibition of syngeneic tumour growth in rats is not dependent on the participation of thymus-processed (t) cells. hosts were deprived of t cells by thymectomy followed by either lethal irradiation (850 rad) and bone marrow reconstitution, or repeated whole body irradiation to a total dose of 1,000 rad. after 6 weeks had elapsed to allow for bone marrow restitution, rats were challenged with trypsini ... | 1976 | 773443 |
| treatment of the mouse lewis tumor by the association of radiotherapy and immunotherapy with bacillus calmette-guérin. | three groups of 6 to 8-week-old male mice with transplanted c57bl/6 x dba/2f1 tumor were irradiated by a single dose of 60co localized on the tumor in association with i.p. injections of lyophilized bacillus calmette-guérin. when the animals were sacrificed, tumor parameters (weight, surface area, and volume) were determined. lung metastases were counted using a binocular magnifying glass. when bacillus calmette-guérin injections were begun the day after the irradiation, tumor growth and the num ... | 1976 | 773530 |
| [melanoma therapy]. | | 1976 | 773624 |
| induction of delayed-type hypersensitivity with bcg-associated proteins. | microgram quantities of bovine serum albumin (bsa) and hen egg albumin (oa) associate spontaneously with living bcg in aqueous suspension. the association is stable insofar as bound protein cannot be readily dissociated from the organism by repeated washing. association of bsa or oa is dependent upon the concentration of specific protein or competing protein in the incubation mixture, ph and the amount of protein already bound to the organisms. washed bcg "complexes" containing either bsa or oa ... | 1976 | 773812 |
| the effects of antigen dose and adjuvant on the antibody response; amplification of restricted b cell clones. | anti-dnp antibody production in inbred strain 2 guinea pigs immunized with chemically defined dnp-oligolysines was enhanced by increasing the antigen dose or employing more potent adjuvants. however, the increase in antibody titer was not accompanied by an increase in antibody heterogeneity. only a small number of anti-dnp antibody-producing b lymphocyte clones were triggered to produce antibody, regardless of the antigen dose or the adjuvant used for immunization or the resulting specific antib ... | 1976 | 774983 |
| effects of bcg on lymphocyte trapping. | the effects of bacillus-calmette guerin (bcg) administration upon lymphocyte traffic was studied in balb/cj mice. intravenous or subcutaneous injection of bcg resulted in increased localization (trapping) of 51cr-labeled syngeneic lymphocytes in the spleen or draining nodes. bcg-induced splenic trapping was biphasic, occurring 1 to 2 days after bcg injection, and reappearing 3 weeks later. trapping in draining lymph nodes persisted and increased during the 24 days of study. these results are in ... | 1976 | 774988 |
| bcg immunotherapy in patients with malignant melanoma. | twenty-one patients with malignant melanoma received immunotherapy with bcg. thirteen patients had adjuvant immunotherapy on a monthly schedule. of these, eight with regional lymph node metastases (stage iii) had been treated by lymphadenectomy. two of the stage iii patients had tumor recurrences within one year, while six are alive and free of melanoma at a median interval of 22 months. the remaining five patients (stage i or ii) had level 4 or 5 (clark classification) primary lesions. their av ... | 1976 | 776125 |
| increase in "null" cells in acute lymphocytic leukaemia in remission on long-term immunotherapy. | | 1976 | 776199 |
| editorial: bcg in cancer. | | 1976 | 776334 |
| overview of tumor immunology in gynecologic oncology. | highlights of recent advances in the field of gynecologic tumor immunology are presented in an effort to demonstrate that at least some cancers of the female genitalia evoke an immune response that can be quantitated in the laboratory. the overview will discuss investigations into the various in vitro assays of both humoral and cell-mediated immunity. the concept of clinical testing of delayed hypersensitivity reactions as it relates to the clinical outcome of the patients with malignancy is pre ... | 1976 | 776391 |
| purification of soluble human melanoma-associated antigens. | soluble extracts of melanoma specimens were prepared by 3 m kcl extraction. delayed cutaneous hypersensitivity reactions to these antigens were noted in 25 of 39 melanoma patients and 7 of 30 patients with other neoplasms. only 4 of 34 melanoma patients reacted to an extract of autologous muscle. maximum reactivity to these antigens occurred at 24 hr and was demonstrated histologically by skin biopsy. chromatography on sephadex g-150 resulted in two fractions that elicited delayed cutaneous hype ... | 1976 | 776393 |
| tumoricidal responses in vitro of peritoneal macrophages from conventionally housed and germ-free nude mice. | | 1976 | 776413 |
| bcg in the therapy of cancer. | | 1975 | 776445 |
| [experimental study of 2d order tuberculostatic preparations in mycobacterium bovis resistance to isoniazid or streptomycin (based on the data from a morphological study)]. | a comparative study on the therapeutic value of the ii line drugs (ethoxide, prothionamide, cycloserin) and bacteriostatics (ethambutol anf rifampicin), with their action upon experimental tuberculosis produced by streptomycin- or isoniazid-resistant mycobacteria of the bovine type, was carried out. this showed rifampicin and ethambutol to be mose effective. ethoxide and prothionamide proved more efficient when acting upon isoniazid-resistant strains. cycloserin turned out to be virtually inacti ... | 1975 | 776650 |
| histochemical studies on fatty acid in lymphocyte-mediated immune reaction. | generation of fatty acids by cell-mediated immune reactions was demonstrated histochemically by okamoto's method, which stains fatty acids and their alkaline earth salts red-brown. the red-brown deposits were observed more frequently on the mixed culture of immune lymph node cells of c3h/he and c57bl/6 mice than on the culture of either of the pair alone. similar evidence was observed in the reaction of immune lymph node cells with the corresponding allogeneic mouse tumour cells as well as on th ... | 1976 | 776819 |
| evaluation of cell mediated immunity in the histopathologic spectrum of leprosy using lymphocyte transformation test. | lymphocyte transformation in response to pha, m. leprae and bcg with the use of measurements of 3h-thymidine uptake, was studied in 10 normal controls, and 71 leprosy patients of different types histologically classified according to the ridley-jopling scale. lepromin and ppd tests were done in each one of them. it was found that there was a generalized depression of immune responsiveness to pha in all forms of leprosy. the immune responsiveness of lymphocytes to m. leprae continuously and gradu ... | 1976 | 776862 |
| [comparison between fixation test with bcg and immunofluorescence in the diagnosis of leishmaniasis]. | the complement fixation test with an antigen from commercially lyophilized bcg and the immunofluorescence test were carried out on serum samples from patients with visceral leishmaniasis, oriental sore and tbc. the ift positivity was obtained only in patients with visceral leishmaniasis. the cft with bcg showed positive results in 3 on 5 serum samples from patients with visceral leishmaniasis, in 2 with oriental sore, at low titres, and in 5 serum samples from patients with tbc. the aa. confirm ... | 1975 | 779671 |
| phage susceptibilities of "mycobacterium bovis" isolates. | | 1975 | 779674 |
| inactivation of the mycophage activity by lipid solvents. | | 1975 | 779675 |
| feasibility study of active immunotherapy in patients with solid tumors. | forty-five immunocompetent patients with solid tumors were immunized with bcg, ppd, and tumor cells. the methods were practical, but the morbidity was significant, including painful draining ulcerations at vaccine sites, possible enhancement of tumor growth in three patients, and the discovery at autopsy of systemic tuberculosis in one patient. various facets of cellular immunity were altered, namely: 1) a majority of the patients developed enhanced cutaneous reactions to the microbial skin-test ... | 1976 | 779950 |
| antibacterial activity of stimulated guinea pig peritoneal exudate cell culture supernates. | | 1976 | 779970 |
| in vitro quantitation of cell-mediated immunity in guinea-pigs by macrophage reduction of nitro-blue tetrazolium. | in the cell-mediated immune (cmi) system lymphocytes from sensitized animals incubated with antigen manufacture and release lymphokines which activate the hexose-monophosphate shunt in macrophages. the rate-limiting enzyme of this activation is nadph oxidase, the activity of which can be quantitated by the amount of nitro-blue tetrazolium reduced to formazan, a blue precipitate. data is presented which demonstrates that lymphokine-activated macrophages can be microscopically quantitated, both in ... | 1976 | 780014 |
| the occurrence of antibodies against single-stranded dna in the sera of patients with acute and chronic leukaemia. | one hundred and seventy-five sera from thirty-three patients with acute myeloid leukaemia, forty-two patients with chronic myeloid leukaemia and twelve patients with acute lymphatic leukaemia were examined by a radioimmunological technique for the presence of antibodies against single-stranded and double-stranded dna. the levels of single-stranded dna binding activity was significantly higher in all three types of leukaemia compared to those of healthy controls. in contrast, none of these sera e ... | 1976 | 780020 |
| effect of systemic bcg infection in syrian golden hamsters. | the response of syrian golden hamsters to systemic infection with several doses of mycobacterium bovis (strain bcg) was assessed. large numbers of organisms (10(7)), injected intravenously, were lethal for hamsters, whereas all animals survived infection with 10(4) colony-forming units of bcg. animals responded immunologically to purified protein derivative as assessed by increased footpad swelling and splenic lymphocyte proliferation. the immediate cause of death was a diffuse granulomatous int ... | 1976 | 780276 |
| [theoretical and practical possibilities of immunotherapy in malignant urologic tumors]. | | 1976 | 780321 |
| immunotherapy of leukemia. | the data reviewed in this paper indicate that immunotherapy is effective in prolonging remission and survival in acute and chronic leukemia. the acute lymphocytic leukemias may or may not respond to immunotherapy and further work is needed in this area. no studies of immunotherapy in chronic lymphocytic leukemia have been done, but this will be an important area for investigation, since there is often profound immunodeficiency in this disease. the malignant lymphomas are another fertile area for ... | 1976 | 781412 |
| identification of an immunosuppressive factor in pregnancy serum. | complement-inactivated allogeneic serum was found to contain a factor capable of suppressing bcg-induced inhibition of leukocyte migration in vitro. although serum from late pregnancy was the most potent in this context, the ability to antagonize the leukocyte response appears to be an intrinsic property of human serum. the inhibitory factor was purified by salf fractionation and gel chromatography and the effect found to be associated with alpha-globulins of high lipid content which are probabl ... | 1976 | 781575 |
| bcg immunotherapy of a mucous membrane malignant melanoma. report of a case. | | 1976 | 781579 |
| in vivo labeling effectiveness of tritiated thymidine of high and low specific activities in rabbits. | | 1976 | 781719 |
| in vivo and in vitro macrophage activation by systemic adjuvants. | six systemic adjuvants of immunity were tested for their ability to induce macrophage activation. four of them: living bcg, hydrosoluble extracts from bcg (hiu ii) and from m.smegmatis (ipm), and lipopolysaccharide from e.coli (lps), when administered to normal mice render macrophages non-specifically cytotoxic for tumor cells in vitro. the intensity of this phenomenon varied according to the route and time of adjuvant administration. in contrast, lentinan extracted from lentinus edodes, and lev ... | 1976 | 782207 |
| lymphocyte stimulation and leucocyte migration inhibition as diagnostic tools for the detection of mycobacterium avium infection in cattle. | | 1976 | 782216 |
| [studies of cellular sensitization to bcg and ppd using leukocyte cell migration inhibition]. | leucocyte inhibition migration test (lmt) with bcg and ppd was applied in pulmonary tuberculosis, lung cancer and sarcoidosis. no significant differences were noticed in the results obtained with each of the two antigenic materials; nevertheless, one case lobectomized of lung cancer successively treated with chemiotherapie and immunostimulation with bcg presented lmt positivity with bcg and negativity with ppd. the unpublished results of the former investigations carried out with brute tuberculi ... | 1975 | 782381 |
| inhibition of drug-metabolizing enzymes in the rat after bacillus calmette-guérin treatment. | | 1976 | 782458 |
| letter: bcg in cancer. | | 1976 | 782649 |
| augmentation of specific macrophage-mediated cytotoxicity: correlations with agents which enhance antitumor resistance. | | 1976 | 782731 |
| oxidative phosphorylation in mycobacterium tuberculosis bcg. | | 1976 | 783037 |