| experimental cancer immunotherapy: comparison of tumor rejection if f344 rats given live mycobacterium bovis (strain bcg) and killed corynebacterium parvum. | f344 rats received grafts of syngeneic 13762 mammary adenocarcinoma cells previously admixed with either living bcg of killed corynebacterium parvum administered sc or intradermally (id). animals given id transplants of tumor cells admixed with either bcg or killed c. parvum exhibited tumor growth for an average of 10 days, then regression in size and rejection of the tumor nodules. lesions were found in rats given sc transplants of tumor cells admixed with the killed microorganism for an averag ... | 1976 | 994209 |
| effects of corynebacterium parvum alone and in combination with adriamycin in experimental tumor systems. | corynebacterium parvum (c. parvum) was used in antitumor tests against four murine tumor models in b6d2f1 mice. the c. parvum was effective at all doses and schedules tested against p388 leukemia, b16 melanoma, and lewis lung carcinoma but was ineffective against l1210 leukemia. combination immunochemotherapy of p388 leukemia and lewis lung carcinoma with c. parvum and adriamycin was better than either regimen alone in increasing the lifespan of mice with tumors. the results show that the effect ... | 1976 | 1009517 |
| effects of corynebacterium parvum treatment and toxoplasma gondii infection on macrophage-mediated cytostasis of tumour target cells. | injection of mice with corynebacterium parvum or living or killed toxoplasma gondii was studied to determine the efficacy of these treatments in activating peritoneal macrophages to inhibit the uptake of [3h]tdr (cytostasis) by tumour target cells in vitro. in the presence of activated macrophages from mice treated i.p. with a wide dose range of either c. parvum or living toxoplasma, cytostasis was usually greater than 99%. this population of activated macrophages was transient in c. parvum-trea ... | 1976 | 992714 |
| the immunostimulant corynibacterium parvum and hematopoietic toxicity of chemotherapy. | | 1976 | 1019832 |
| mouse strain differences in macrophage activation and anti-tumor activity induced by propionibacterium acnes (anaerobic coryneforms). | effect of propionibacterium acnes on macrophage activation and antitumor activity was examined in ddn and sl mice. (1) carbon clearance was enhanced to the same extent by p. acnes treatment in both strains. (2) number of peritoneal macrophages increased to the same extent by p. acnes treatment in both strains. (3) adhesiveness of peritoneal macrophages, as demonstrated by inhibition or migration or an increase in spreading cells, was enhanced more efficiently in ddn than in sl mice p. acnes tre ... | 1976 | 1021506 |
| immunological enhancement of leukemia l1210 by corynebacterium parvum in allogeneic mice. | the effect of corynebacterium parvum on the immune response of c57bl/6 mice (h-2b) to the allogeneic leukemia l1210 (h-2d) was investigated. mice were either left untreated or given c. parvum i.v. or i.p. in various dosages. seven days later they were challenged with 2.5 to 10 x 10(6) live l1210 cells i.p. control animals almost always rejected the challenge. in contrast, most mice pretreated with either 1.0, 0.5, or 0.25 mg of c. parvum i.v. and 1.0 or 0.5 mg i.p. exhibited enhanced growth of l ... | 1976 | 975053 |
| identification of propionibacterium acnes and related organisms by precipitin tests with trichloroacetic acid extracts. | the serological identification of propionibacterium acnes, p. granulosum, and p. avidum, using trichloroacetic acid extracts, is described. with antisera prepared against reference strains, the method has been tested on 142 strains recently isolated from human skin. all except two of the strains could be identified serologically, and there was excellent agreement between the serological results and the fermentation pattern of the strains. two serological types of p. acnes and two of p. avidum we ... | 1976 | 972178 |
| treatment of rat fibrosarcoma by radiotherapy plus immune adjuvant. | combined radiotherapy and nonspecific adjuvant c. parvum or piromen treatment of rat tumors show improvement over radiotherapy alone. the most effective protocol, resulting in complete remission in 6 of 6 rats was obtained with c. parvum given i.p. in three doses 1 day prior to tumor x-irradiation of three doses of 1500 r each given on days 1, 4, and 8. animals receiving the same dose schedule without adjuvant had only partial regression of their tumor. without adjuvant, increasing the dose to 6 ... | 1976 | 949523 |
| studies on the enhancement by cyclophosphamide (nsc-26271) of artificial lung metastasis after labeled cell inoculation. | in a mouse model the retention of125i-5-iodo-2' -deoxyuridine-labeled tumor cells in the lung after iv injection was compared with the formation of tumor colonies in the lung 15 days after injection. the modification in lung retention after treatment with cyclophosphamide (cp), isophosphamide, corynebacterium parvum, and heparin paralleled the changes in lung-colony numbers by these treatments. since the modifications could be identified as early as 1 hour after iv administration of tumor cells, ... | 1976 | 1064469 |
| observations following corynebacterium parvum administration to patients with advanced malignancy. a phase i study. | there has been increasing interest regarding the use of corynebacterium parvum (cp) with other modalities in the management of primary cancer. due to the paucity of specific information available relative to cp toxicity, a phase i study was carried out in patients with advanced disease. the purpose of the investigation was not to evaluate the effect of cp on tumor growth. from 273 injections of cp in 40 patients it was observed that following intravenous (i.v.) infusion of cp: a) a febrile respo ... | 1976 | 947509 |
| taxonomical position of anaerobic diphtheroids from human oral cavity. | | 1976 | 1076074 |
| mechanisms of macrophage activation by corynebacterium parvum. ii. in vivo experiments. | | 1975 | 1079165 |
| paradoxical effects of immunopotentiators on tumors and tumor viruses. | growth of tumors was inhibited or enhanced in mice by a synthetic (pyran) or a biologic (corynebacterium parvum) immunopotentiator. marked inhibition of leukemogenesis induced by friend leukemia virus was produced by prophylactic intraperitoneal treatment with pyran, while intravenous treatment with pyran (in the same dose and regimen) significantly enhanced growth of tumor virus. paradoxical effects were also seen with the biologic immunopotentiator c. parvum in solid tumor systems. treatment w ... | 1976 | 932503 |
| effect of local injection of corynebacterium parvum on the growth of a murine fibrosarcoma. | local injection (i.e. injection at the site of tumour inoculation) of strains of c. parvum which have a significant anti-tumour effect when given systemically (i.e. intravenously or, in the case of subcutaneous tumour transplant, intraperitoneally) strongly inhibits the growth of isogeneic transplants of a fibrosarcoma in intact cba mice but has little or no effect on subcutaneous transplants of the same tumour in t-cell deprived mice. the anti-tumour effect of local injection of c. parvum, unli ... | 1975 | 1080671 |
| expression of a new cell surface antigen on activated murine macrophages. | a macrophage cell-surface antigen associated with pyran and corynebacterium parvum-activated macrophages and p388d1 cells but not detectable on normal or glycogen and thioglycollate-elicited murine macrophages has been described. the antigen was demonstrated both by complement-mediated cytotoxicity and immunofluorescence, using an appropriately absorbed rabbit antiserum to p388d1. this antiserum should enable the characterization of activated macrophage cell populations on an individual cell bas ... | 1977 | 925608 |
| further observations on the diagnosis cause, and treatment of endophthalmitis. | in our study of 54 suspected cases of endophthalmitis, vitreous aspiration was more sensitive in making a culture-proven diagnosis than anterior chamber paracentesis; staphylococcus epidermidis was a more common cause of endophthalmitis than previously appreciated; and intraocular antibiotics in the recommended dosage are reasonably safe clinically and add a new dimension to the treatment of endophthalmitis. | 1976 | 1082716 |
| immunotherapy: concepts and nursing implications. | concepts of immunlogy and the human immune system are essential for an understanding of the rationale of immunotherapy. immunotherapy is presently being investigated as adjunct therapy for patients with cancer. it is therefore essential for the professional nurse to become cognizant of the various modalities and possible complications of immunotherapy in order that the nursing implications may be incorporated into clinical practice. | 1976 | 1083016 |
| effects of corynebacterium parvum on tumour metastases in mice. | | 1977 | 922293 |
| effect of corynebacterium parvum on cellular and humoral antitumoral immune effector mechanisms. | | 1976 | 1083341 |
| investigations on prostatic adenocarcinomas in rats. | metastatic prostate adenocarcinomas, derived from aging germfree wistar rats, have been propagated in rats and in tissue culture. a protocol has been developed and demonstrated for assay of treatments which retard or which accelerate the rate and extent of tumor growth and of metastasis in tumor-bearing rats. the pattern of spread has been retarded by cyclophosphamide, aspirin, indomethacin, and corynebacterium parvum. the spread pattern has been accelerated by oral administrations of sodium bar ... | 1977 | 917442 |
| increase of phagocytic activity and new appearance of a c4b (guinea pig) recognizing capability in peritoneal macrophages from corynebacterium parvum and thioglycollate-stimulated mice. | activated mouse macrophages displayed enhanced phagocytic activity towards particles opsonized with igg antibody and homologous c3. in addition, they were able to recognize guinea pig c4b. it is concluded that activated macrophages develop phagocytically active receptors for heterologous c4b. | 1977 | 917013 |
| local control and disease-free survival after treatment of a squamous cell carcinoma by corynebacterium parvum and local irradiation. | | 1977 | 908026 |
| osteosarcoma: a reconnaissance. | | 1975 | 1091399 |
| mechanisms of macrophage activation by corynebacterium parvum. i. in vitro experiments. | | 1975 | 1092470 |
| effect of immunomodulators on effector cells involved in antibody-dependent cellular cytotoxicity: brief communication. | the effect of four immunomodulators (bcg, corynebacterium parvum, pyran copolymer, and levamisole) on the cellular arm of antibody-dependent cellular cytotoxicity (adcc) was investigated in mice with 51cr-labeled chicken erythrocytes employed as targets. all these drugs, except levamisole, stimulated the effector cells of adcc in the spleen, but the kinetics of their effect differed. stimulation of the effector cells of adcc peaked on day 15 after injection of bcg and c. parvum and on day 7 afte ... | 1977 | 894742 |
| rejection of mammary adenocarcinoma cell tumors in dba/2 mice immunocompromised by thymectomy and treatment with antithymocyte serum. | syngeneic mammary adenocarcinoma cells were mixed with killed corynebacterium parvum organisms and were then transplanted subcutaneously into groups of normal and immunocompromised mice. the tumors formed at the site of injection exhibited normal growth for approximately 12 days followed by rapid and lasting rejection in both normal and immunocompromised animals. the control mice were protected against reinjections of 10-4 to 10-8 cells of the same line of tumor cells. the immunocompromised mic ... | 1975 | 1092759 |
| tumor inhibitory properties of anaerobic corynebacteria. | | 1975 | 1093294 |
| mechanism of the anti-tumour effect of glucans and fructosans: a comparison with c. parvum. | the anti-tumour activity induced by glucans (lentinan, yeast cell walls, pseudonigeran, dextran, deae-dextran and dextran sulphate) and fructosans (levan and carboxymethyl-levan) was compared with the activity of c. parvum. the following effects on tumour systems in cba mice were assayed: (a) adjuvant activity on the immune response against tumour-specific transplantation antigens (tsta) with a methylcholanthrene-induced fibrosarcoma; (b) cytostatic activity of peritoneal macrophages against rad ... | 1977 | 889684 |
| [a study on the nature of corynebacterium acnes (author's transl)]. | | 1975 | 1099281 |
| the role of macrophages in the amplified in vitro response to sheep red blood cells by spleen cells from corynebacterium parvum treated mice. | | 1975 | 1102113 |
| nonspecific enhancers of resistance in man. | nonspecific enhancers of resistance may include (1) viral interference, (2) interferon, (3) interferon inducers, (4) bacterial interference, (5) bacterial products such as coley's "toxins," endotoxins, or staphylococcal, bcg, and corynebacterium parvum vaccines, (6) transfer factor, and (7) well-defined chemicals such as dinitrochlorbenzene, levamisole, and vitamin c. these are discussed only as they have been applied to man to learn whether or not they have enhanced his ability to resist infect ... | 1975 | 1102645 |
| effects of bcg, corynebacterium parvum, and methanol-extration residue in the reduction of mortality from staphylococcus aureus and candida albicans infections in immunosuppressed mice. | an immunosuppressed mouse model was devised to test the effects of immunopotentiators on the prevention of bacterial and fungal infections. the effects of bcg and corynebacterium were tested against staphylococcus aureus and candida albicans infection. the effect of methanol-extraction residue (mer-bcg) was tested against s. aureus septicemia. cdf mice were given various doses of bcg, 1.0 mg of c. parvum, or 0.5 mg of mer intraperitoneally at varying intervals before injection of an intravenous ... | 1975 | 1107224 |
| intravascular coagulation resulting from intravenous injection of c. parvum in mice. | in mice, i.v. c. parvum induces intravascular coagulation. this is a prolonged reaction lasting up to 7 days. it results in thrombosis in hepatic vessels with consequent hepatic necrosis, and thrombosis in pulmonary and splenic vessels. this may be important in the assessment of the tumour-inhibitory activity of c. parvum. | 1977 | 889682 |
| immunological response in patients receiving corynebacterium parvum therapy. | | 1977 | 872468 |
| proceedings: combined surgery and corynebacterium parvum for treatment of metastasizing tumour in mice. | | 1975 | 1115892 |
| proceedings: the action of subcutaneous and intravenous corynebacterium parvum on the "lymphocyte trap". | | 1975 | 1115893 |
| separation and characterization of epithelial cells from prostates and prostatic carcinomas: a review. | our investigation of normal, hyperplastic, and neoplastic prostatic tissue during the past 2 1/2 years has produced several findings which have been published or accepted for publication. (a) cells from hamster prostates with intense histochemically demonstrable acid phosphatase activity (hdap) after fixation with formaldehyde which we believe to be epithelial cells can be obtained in 97.2% +/- 0.8% purity by velocity sedimentation in a previously described isokinetic density gradient; (b) simil ... | 1977 | 872127 |
| effect of corynebacterium parvum on bone marrow cell cultures (38557). | the effect of c. parvum on in vitro colony-forming cell was evaluated. a single ip injection of the vaccine had no effect during the first 4 hr either on colony stimulating factor or on colony-forming cells. the enhancement of the colony-forming capacity of the bone marrow by c.parvum occurred after two injections of the vaccine within 48 hr. the stimulation of colony formation by c. parvum was time related function and occured 5 days after the initiation of the cultures. the results of this ... | 1975 | 1121493 |
| cancer immunology. | | 1975 | 1135940 |
| radiation response of c3h fibrosarcoma enhanced in mice stimulated by corynebacterium parvum. | | 1975 | 1138200 |
| comparative effect of anaerobic coryneforms on a murine melanoma. | ten strains of anaerobic corynebacteria were compared in their effect on survival of c57bl/6 mice, bearing subcutaneously inoculated b16 melanomas. the corynebacterial suspensions were injected intralesionally twice weekly for five injections. significant permanent tumor regression was not obtained. significant prolongation of survival was observed in mice treated with seven of the corynebacterial strains. | 1977 | 872039 |
| esterification of (4--14c)cholesterol by cutaneous bacteria (staphylococcus epidermidis, propionibacterium acnes, and propionibacterium granulosum). | cholesterol and cholesteryl esters constitute 3 to 5% of the lipids derived from human sebaceous glands. the present study demonstrates that cutaneous bacteria, staphylococcus epidermidis, and to a lesser extent propionibacterium acnes, and propionibacterium granulosum, esterify [4--14c]cholesterol to steryl esters in vitro. the degree of esterification is a characteristic of the strain of organism, ranging from 0 to 32.7% in the organisms tested. cholesterol esterification in these experiments ... | 1975 | 1141713 |
| further analysis of the anti-tumour effect in vitro of peritoneal exudate cells from mice treated with corynebacterium parvum. | administration of c. parvum to both intact and thymectomized mice resulted in the appearance in the peritoneal exudate of cells which inhibited tumour growth in vitro. this effect was mediated by intact, viable adherent cells, which it seems reasonable to categorize as macrophages, and was contingent on contact between the effector and target cells. no co-operation was observed between lymph node cells from c. parvum treated mice and peritoneal exudate cells from normal mice. | 1975 | 1156505 |
| lack of immunological and anti-tumour effects of orally administered corynebacterium papvum in mice. | | 1975 | 1156520 |
| the distribution and persistence in vivo of corynebacterium parvum in relation to its antitumor activity. | killed corynebacterium parvum was labeled with fluorescein isothiocyanate or 125i, and both preparations were shown to retain lymphoreticular stimulatory and antitumor activity. large amounts of c. parvum injected i.v. were found in the liver, spleen, and lungs with less in bone marrow and lymph nodes. apart from a rapid loss from the lungs within 24 hr, the persistence of killed c. parvum was striking, and some intact bacteria were still detectable in the liver and spleen at 15 days. (by contra ... | 1977 | 870181 |
| an analysis of the factors allowing promotion (rather than inhibition) of tumour growth by corynebacterium parvum. | the following factors were found to determine whether c. parvum (cp) treatment promoted rather than inhibited the growth of methylcholanthrene-induced fibrosarcoma cells injected into cba mice. (1) the dose of tumour cells. promotion occurred only with low doses, around the td50. (2) the route of injection of cp. greater promotion was caused by intravenous (iv) than by subcutaneous (sc) administration. addition of irradiated tumour cells to sc cp resulted in tumour inhibition. (3) the dose of cp ... | 1977 | 863546 |
| serological studies of actinomyces israelii by crossed immunoelectrophoresis: taxonomic and diagnostic applications. | crossed immunoelectrophoresis (cie) with intermediate gel was applied to the serological analysis of actinomyces israelii to develop a test with high efficiency in the laboratory diagnosis of human actinomycosis and classification of a. israelii. recently developed standard antigen-antibody systems for a. israelii by cie were used as reference. the reference systems were based on standard preparations of cytoplasmic and whole cell-associated antigens of a. israelii and a standard immunoglobulin ... | 1975 | 1171825 |
| role of cellular proliferation in the stimulation of mps phagocytic activity. | administration of agents such as stilboestrol, endotoxin, c. parvum and zymosan, which enhance the phagocytic activity of the mononuclear phagocyte system, also stimulated cellular proliferation in the liver and spleen as assessed by [13h] thymidine incorporation into these organs, and by autoradiography and the number of mitoses in the liver. sublethal whole body irradiation abolished the proliferative response to stimulation and also reduced or prevented the increase in phagocytic activity. th ... | 1975 | 1174456 |
| bacteriology of normal and infected conjunctiva. | the conjunctivas of 273 inflamed eyes were cultured by both aerobic and anaerobic techniques. isolations were obtained from 267 (97.8%) of the eyes. aerobic organisms were isolated from 237 (86.8%) of the conjunctivas. staphylococcus aureus from 63 (23.1%) of the diseased eyes was the aerobic pathogen most often isolated. anaerobic bacteria were isolated from 172 (63.0%) of the conjunctivas. propionibacterium acnes was isolated from 126 (46.2%) of the conjunctivas, and peptostreptococcus species ... | 1975 | 1176598 |
| the role of nonspecific immunotherapy in the treatment of breast cancer. | | 1976 | 1013508 |
| age-related changes in the resident bacterial flora of the human face. | quantitative levels of resident aerobic and anaerobic bacteria of the face, show a characteristic age-related pattern. the density of anaerobic diptheroids and surface aerobic micrococci is higher in infancy than in early childhood. at puberty the quantity of organisms increases, with significantly higher levels achieved in late adolescence. maximum counts are attained in early adulthood and remain constant until old age when a trend toward lower numbers occurs. these changes seem to correlate w ... | 1975 | 1176788 |
| infection after total knee arthroplasty. | | 1975 | 1178156 |
| further observations on the inhibition of tumor growth by corynebacterium parvum with cyclophosphamide. | the cytotoxic macrophage was further characterized as an important effector cell in the inhibition of tumor growth. when we administered rifampin (a semisynthetic antibiotic that interferes with macrophage function but not viability) with corynebacterium parvum and/or cyclophosphamide to tumor-bearing c3heb/fej female mice, the tumor growth-inhibitory effects of the c. parvum were reduced. moreover, when bone marrow cells from those animals were cultured, we found a marked decrease in the cytoto ... | 1976 | 1003514 |
| further observations on the inhibition of tumor growth by corynebacterium parvum with cyclophosphamide. iii. effect of c. parvum on cyclophosphamide metabolism. | results of investigations employing [14c]cyclophosphamide (cy) demonstrated that even though total plasma radioactivity was similar in female c3heb/fej mice treated either with cy alone or corynebacterium parvum and cy, the proportion of total activity due to nonmetabolized cy was greater when c. parvum was used. these findings indicated that the antitumor effect of c. parvum may not have been entirely due to its immunopotentiating properties but may also have been related to its effect on the m ... | 1976 | 1003505 |
| [modification of infectious-allergic processes by oral administration of antigens]. | the oral administration of appropriate antigens causes a decrease in sensitization as shown by the models of tuberculin allergy in guinea pigs and of the sensitization of guinea pigs and rabbits to corynebacterium acnes antigens. | 1975 | 1193528 |
| studies on bacteriophages of propionibacterium acnes. | with the help of adaptation experiments, 61 phage preparations out of 36 propionibacterium acnes bacteriophages (32 isolated by us and 4 sent from abroad) were established. on the basis of their stability, spectrum of activity, and virulence, 13 phages were selected for phagetyping. 58 well-classified p. acnes strains were grouped into 7 phage-types. 7 strains of p. granulosum, two strains of p. avidum, and one yet ungroupable microserophilic propionibacterium strain were resistant to all 61 pha ... | 1975 | 1196261 |
| decreased liver and lung drug-metabolizing activity in mice treated with corynebacterium parvum. | injections of killed suspensions of corynebacterium parvum (i.p.) in young male mice were followed by time- and dose-dependent decreases in the drug-metabolizing activity of liver microsomes and lung homogenates. in vitro assays with model substrates [aminopyrine, aniline, p-nitroanisole, and benzo(a)pyrene] were used to quantitate drug-metabolizing activity. it is likely that such decreases in mixed function oxidases activity will act to significantly alter the pharmacokinetics of concurrently ... | 1976 | 1000491 |
| haematological changes and iron metabolism in rats after administration of corynebacterium parvum. | administration of 1-4 mg of c. parvum to rats caused a transient and mild normochromic and normocytic anaemia with reticulocytosis. there was also an immediate and marked fall of plasma iron concentration and a moderate increase of total iron binding capacity of plasma. despite increased clearance of 59fe from the plasma there was no significant change of the plasma iron turnover rate. at later intervals after administration of c. parvum an increased incorporation of iron into red blood cells an ... | 1975 | 1203175 |
| activation of the classical and alternate pathways of complement by corynebacterium parvum. | the immunological adjuvant corynebacterium parvum has been to activate the alternate pathway of complement in human and guinea-pig serum. human serum in addition contains anti-c. parvum antibodies leading to activation of the classical complement pathway. the possible role of a c. parvum derived polysaccharide in this activation is considered in relation to the biological effects of the micro-organism. | 1975 | 1204238 |
| complement activation in vivo in cancer patients receiving c. parvum immunotherapy. | serum complement levels were assayed in 26 patients with disseminated cancer, who received immunotherapy with infusion of c. parvum. complement activation, indicated by the consumption of c3 or c4 or both, was found in 46% of the patients. serum samples showed direct correlation between decreased c3 and conversion of c3 proactivator, whereas such conversion did not occur when c4 alone was decreased. it is concluded that the bypass (properdin) pathway was activated in patients in whom c3 consumpt ... | 1976 | 999783 |
| antitumor activity of killed corynebacterium parvum suspensions in a murine mammary adenocarcinoma cad2) system. | we studied the antitumor activity of killed corynebacterium parvum on the cad2 mammary adenocarcinoma in dba/2 mice. intratumor treatment had little or no effect on subcutaneous tumor growth. admixture of tumor cells with c. parvum before inoculation completely suppressed tumor growth. no tumor transplantation immunity was detected in mice inoculated with admixtures of c. parvum and tumor cells, but tumors were enhanced under certain circumstances. growth of a tumor inoculated sc or iv was consi ... | 1976 | 994219 |
| proceedings: therapy of methyl cholanthrene induced cba mouse tumours with corynebacterium parvum and irradiated tumour cells. | | 1975 | 1212356 |
| anaerobic and aerobic skin bacteria before and after skin-disinfection with chlorhexidine: an experimental study in volunteers. | the amount, composition, and localization of anaerobic and aerobic bacteria in the normal skin before and after disinfection were the subject of a volunteer study. the superficial bacterial flora were sampled by velvet pad imprints, and the deep flora were determined from whole skin biopsies. only one anaerobic species, propionebacterium acnes, was encountered even though other and more strict anaerobic bacteria could have been grown with the anaerobic technique employed. staphylococcus albus do ... | 1975 | 1214012 |
| effect of prolonged corynebacterium parvum and cyclophosphamide administration on spontaneously occurring metastases. | | 1975 | 1216089 |
| [management of acute leukemias and linphosarcomas with active immunotherapy (author's transl)]. | | 1975 | 1056311 |
| suppression of the incidence of death with spontaneous tumours in dba/2 mice after corynebacterium parvum-mediated rejection of syngeneic tumours. | | 1976 | 1250378 |
| enhancement by drugs of metastatic lung nodule formation after intravenous tumour cell injection. | in studies on a model of induced pulmonary metastasis in mice a tumour host system was analysed which was not affected by immunogenicity of the tumour for the host; neither intensive immunosuppression nor immunization caused a significant change in the quantity of pulmonary metastatic nodules. in contrast the application of cytostatic drugs and of corynebacterium parvum could modify the pulmonary resistance to the formation of tumour nodules by a factor greater than 100 in either direction. this ... | 1975 | 1056314 |
| new experimental and clinical data on leukaemia immunotherapy. | the present results of our treatment of acute lymphoid leukaemia patients are summarized: 7 out of 20 randomized patients given active immunotherapy after chemoradiotherapy are still in complete remission after periods varying from seven to ten years (compared to none in the control group). the actuarial results on 100 patients show remission and survival curves presenting a plateau between three and five years for a certain percentage, suggesting a possible cure. several parameters studied in 2 ... | 1975 | 1060146 |
| macrophage mediated tumor cell cytotoxicity. | the following evidence from our research has implicated the macrophage as an important effector cell in pyran and/or c. parvum induced host resistance to solid tumors: (1) increased infiltration of tumors with histiocytes following systemic treatment with pyran;17 (2) activated peritoneal macrophages with tumoricidal activity have been recovered from the peritoneal cavity of normal or tumor bearing mice treated with pyran or c. parvum;17 (3) activated peritoneal macrophages mixed with tumor cell ... | 1976 | 1071961 |
| daily intravenous infusions of corynebacterium parvum in twenty patients with disseminated cancer: a preliminary report of clinical and biologic findings. | twenty terminally ill patients with various disseminated tumors were treated with daily iv infusions of corynebacterium parvum given alone at doses of 4 mg/day, 5 days/week, for 4-16 weeks. in 8 patients (40%), the lesions partially regressed to less than 50% of their original size. another patient who did not improve with c. parvum therapy had a complete remission after the first course of chemotherapy. skin tests, total leukocyte counts, and t- and b-cell counts revealed variable and unpredict ... | 1975 | 1080521 |
| active specific immunotherapy of mouse methylcholanthrene induced tumours with corynebacterium parvum and irradiated tumour cells. | the relative efficiency of active nonspecific or specific immunotherapy of developing methylcholanthrene induced fibrosarcomata with c. parvum was compared. for nonspecific immunotherapy, mice were challenged with tumour cells s.c. or i.v., and 2 days later injected i.v. with dilutions of c. parvum. the only significant effect was a retardation of s.c. tumour growth by the highest concentration of c. parvum (350 mug). however, active specific immunotherapy, using mixtures of c. parvum and irradi ... | 1975 | 1082344 |
| the accumulated effects of repeated systemic or local injections of low doses of corynebacterium parvum in mice. | the effects of 14 weekly injections, s.c. or i.v., of "human equivalent" doses (5.25 mg/sq m) of corynebacterium parvum (cp) in mice have been compared. both s.c. and i.v. cp caused significant splenomegaly and antibody to cp, but stimulation was considerably greater after i.v. cp. delayed hypersensitivity levels to cp were similar after s.c. and i.v. injection. t-cell competence, as judged by phytohemagglutinin reactivity and delayed hypersensitivity to sheep cells, was unimpaired after s.c. cp ... | 1976 | 1083289 |
| the effect of corynebacterium parvum on the humoral and cellular immune systems in patients with breast cancer. | corynebacterium parvum, a gram-positive anaerobic bacillus thought to be a strong immunological stimulant, has been shown to decrease tumour growth and prolong survival in patients with metastatic disease. study of the effect of a single injection of a strain of c. parvum (cn. 6134) in six patients with stage iv metastatic breast cancer is reported. results of laboratory tests to judge the physical and immunological effects of the drug infusion 24 hr post-treatment and weekly thereafter for 3 we ... | 1976 | 1084821 |
| abrogation of the anti-metastatic activity of c. parvum by antilymphocyte serum. | | 1976 | 1086096 |
| mechanisms of antitumor action of corynebacterium parvum: replicating short-lived t cells as the mediators of potentiated tumor-specific immunity. | | 1976 | 1086362 |
| effect of corynebacterium parvum on the class and subclass of antibody produced in the response of different strains of mice to sheep erythrocytes. | several strains of mice were injected with sheep erythrocytes (srbc) using c. parvum as adjuvant. the adjuvant effects on the amounts of class and subclass of antibody produced were ranked in the order igg2b greater than igg2a and igm greater than igg1. in addition, these effects were shown to vary depending on the time of administration of c. parvum relative to antigen. c parvum was shown to have no adjuvant effect on the response of congenitally athymic mice when given at the same time as the ... | 1975 | 1092609 |
| suppression of the immune response by microorganisms. | | 1975 | 1095003 |
| inhibitory effect of prolonged corynebacterium parvum and cyclophosphamide administration on the growth of established tumors. | the present study was carried out to investigate the effects of prolonged administration of c. parvum alone and in combination with cyclophosphamide for the treatment of established, measurable c3h tumors. the continued weekly administration of c. parvum by itself provided a limited but significant inhibitory effect on tumor growth and significantly prolonged survival. intraperitoneal and intravenous administration was found to be more effective than the subcutaneous route. when c. parvum was ad ... | 1975 | 1109767 |
| specific and nonspecific stimulation of resistance to the growth and metastasis of the line 1 lung carcinoma. | the effects of specific dead tumor cell immunization and nonspecific immunostimulation with corynebacterium parvum on the s.c. growth of the line 1 carcinoma in syngeneic balb/c mice have been studied. injection of heavily irradiated line ) carcinoma cells did not inhibit the transplantability or growth of the line 1 carcinoma, and in certain cases these treatments actually prolonged the period of rapid growth. this latter observation was traced to a mild inhibition of metastatic spread, which i ... | 1975 | 1109793 |
| a comparative study of anaerobic coryneforms. attempts to correlate their anti-tumour activity with their serological properties and ability to stimulate the lymphoreticular system. | various strains of anaerobic coryneforms and the closely related propionibacteria have been compared in vivo with respect to their anti-tumour activity. their effectiveness has been correlated with their serological relationship and to some extent with their ability to stimulate the lymphoreticular system. organisms belonging to corynebacterium acnes groups i and ii and c. avidum group iv were active anti-tumour agents, although of varying effectiveness. these strains are serologically closely r ... | 1975 | 1116870 |
| the in vitro killing of syngeneic cells by peritoneal cells from adjuvant-stimulated mice. | | 1975 | 1139640 |
| modifications in the handling in vitro of 125i-labelled keyhole limpet haemocyanin by peritoneal macrophages from mice pretreated with the adjuvant corynebacterium parvum. | peritoneal macrophages were isolated from c. parvum-pretreated (cp) and normal cbat6t6 mice and their in vitro handling of 125i-labelled keyhole limpet haemocyanin (125i-labelled klh) studied in relation to the humoral anti-klh responses induced in corresponding animals. cp pretreatment exerted an adjuvant effect on the production of anti-klh antibodies, both igm and igg, which was also demonstrable with a normally subimmunogenic dose of antigen. there was a clear difference between the handling ... | 1975 | 1158386 |
| proceedings: treatment of a metastasizing murine tumour with corynebacterium parvum. | | 1975 | 1164486 |
| splenic suppressor macrophages induced in mice by injection of corynebacterium parvum. | spleen cells from c57bl/6n mice injected with killed corynebacterium parvum (cp) had a marked growth inhibitory effect on the in vitro proliferation of rbl-5 murine lymphoma cells. it was most marked 12 to 14 days after injection and was usually no longer detectable later than 21 days. it could be demonstrated at effector cell to target ratios between 20:1 and 5:1 at which normal spleen cells had a growth-promoting effect. addition of cp to an in vitro mixture of spleen cells and tumor cells aug ... | 1975 | 1176773 |
| combination of c. parvum and specific immunization against artificial pulmonary metastases in mice. | we have studied whether specific immunization administered intraperitoneally can augment the activity of c. parvum (0.25 mg intraperitoneally or intravenously) against intravenously injected cells of a syngeneic fibrosarcoma in c3hf/bu mice as expressed by the reduction of pulmonary metastases (nodules, colonies) and/or by the prolongation of the survival of recipients. combination of specific immunization and c. parvum, applied either before or after iv inoculation of viable tumor cells, was mo ... | 1975 | 1184241 |
| [letter: immunotherapy in malignant melanoma]. | | 1975 | 1188912 |
| mycoplasmas and 'diphtheroids' in rheumatoid arthritis. | the failure to isolate conventional mycoplasmas from 88 synovial membranes and 119 synovial fluids from patients with proven rheumatoid arthritis using a variety of culture media and techniques agrees with the results of recent workers and suggests that these organisms are unlikely to play a role in the aetiology of the disease. in contrast, 'diphtheroid' organisms were isolated from 27 to 30% of rheumatoid specimens, but not from cultures of non-rheumatoid material. a significantly higher incid ... | 1975 | 1202604 |
| further observations on the inhibition of tumor growth by corynebacterium parvum with cyclophosphamide. i. variation in administration of both agents. | studies from this laboratory have indicated that the administration of cyclophosphamide (cy) and corynebacterium parvum (cp) over a prolonged time to c3h mice with established measurable tumors resulted in complete arrest of tumor growth as well as partial and complete regressions in many instances. the present investigations on optimal dosage, route, frequency, and sequence of administration of cy and cp in the model system were performed to obtain information that could be useful in the design ... | 1975 | 1206740 |
| mchanisms of antitumor action of corynebacterium parvum: nonspecific tumor cell destruction at site of immunologically mediated sensitivity reaction to c. parvum. | mice immunized in the footpad with corynebacterium parvum developed a systemic mechanism with a potential for destroying syngeneic tumor cells. the development of this mechanism of antitumor action depended on the generation of a state of systemic sensitivity to c. parvum antigens, which allowed an immunologically mediated inflammatory response to be focused at the site of a tumor cell challenge or in the bed of an established tumor. this resulted in complete inhibition of growth of the former r ... | 1975 | 1206760 |
| responsiveness of senescent mice to the antitumor properties of corynebacterium parvum. | the antitumor properties of corynebacterium parvum have been studied in young (3- to 8-month-old) and aged 18 or more months old) balb/c mice given s.c., i.m., i.p., or i.v. transplants of the highly malignant, weakly immunogenic line 1 lung carcinoma, and in aged (25- to 33-month-old) balb/c mice bearing primary mammary tumors. these aged balb/c mice were shown to be less immunoresponsive than their younger counterparts, and this, in combination with nonimmunological factors, made them more sen ... | 1976 | 1247995 |
| studies on the fc receptor bearing cells in a transplanted methylcholanthrene induced mouse fibrosarcoma. | the presence of fc receptors on the surface of cell suspensions obtained from a transplanted isogeneic methylcholanthrene induced murine fibrosarcoma has been investigated by determining the capacity of such cells to form rosettes with antibody coated srbc. these studies indicate that a large percentage of cells in the tumour had fc receptors on their surface. the proportion of such cells was increased by reducing the number of cells transplanted, by administering cyclophosphamide to the host, a ... | 1976 | 1252329 |
| proceedings: immunological mechanisms involved in the inhibition of tumour metastases by corynebacterium parvum. | | 1976 | 1252731 |
| antitumor activity of corynebacterium parvum extracts. | extracts of corynebacterium parvum produced by mild hydrolysis of the whole organisms had antitumor activity if given iv 1 day before iv administration of fibrosarcoma cells or if given ip or sc in admixture with these cells. a lipid component seemed responsible for these effects. unlike whole bacteria, they had little immunotherapeutic activity if given 3 days after sc tumor implantation unless absorbed onto latex. however, organisms treated with acid did not have any immunotherapeutic effect i ... | 1976 | 1255777 |
| further observations on the inhibition of tumor growth by corynebacterium parvum with cyclophosphamide. ii. effect of cortisone acetate. | studies from this laboratory have demonstrated that the administration of cyclophosphamide (cy) and corynebacterium parvum (cp) over a prolonged time to c3h mice with established measurable tumors resulted in complete arrest of tumor growth as well as partial and complete regressions in many instances. a study of the effect of two different doses of cortisone acetate (ca), administered two or five times weekly, on the tumor inhibitory properties of this chemoimmunotherapeutic regimen indicated t ... | 1976 | 1255788 |
| anaerobic infections in children: a prospective study. | the prevalence and significance of anaerobic infections in patients at st. louis children's hospital were studied prospectively for a one-year period. blood, selected body fluids, and aspirates obtained from abscesses or areas of cellulitis were cultured using special anaerobic collection and processing techniques. infected peritoneal fluid from patients with gastrointestinal disease yielded a large proportion of all anaerobic isolates. the types of organisms isolated were common inhabitants of ... | 1976 | 1256941 |
| immunotherapy and human tumor immunology. | present knowledge about the immune response to tumors in man is briefly reviewed, and the effects of cancer on immune-system functions are noted. the concepts that human tumors elicit cell-mediated immune responses to tumor antigens are re-examined and modified; for example, cell-mediated immunity may be detectable only at certain stages of tumor growth. introduction of more sensitive methods for detecting antibodies is providing additional evidence for humoral immune responses to tumor-associat ... | 1976 | 1259292 |
| effect of corynebacterium parvum on the response to irradiation of a c3h fibrosarcoma. | a methylcholanthrene-induced fibrosarcoma of c3h mice has been used as 5th- to 6th-generation syngeneic transplant in an investigation of the role of corynebacterium parvum as an adjuvant to the therapeutic effect of local irradiation of established tumors. the most effective route for administration of c. parvum in this tumor system was i.v., and the greatest effect of the c. parvum-mediated tumor graft rejection was observed for tumor growing intracutaneously or s.c. an intermediate level of e ... | 1976 | 1260756 |
| antitumour effect of corynebacterium parvum. possible mode of action. | | 1976 | 1268035 |
| bioassay for quantitating circulating tumor cells in a syngeneic mouse tumor system. | a bioassay is described for the quantitation of tumor cells in blood specimens in a syngeneic mouse tumor system (sarcoma 1 in a/j mice). the procedure involved i.m. injection of blood containing tumor cells into each thigh of normal recipient mice and, 14 days later, examination of the sites of injection for evidence of tumor growth. for each specimen, a tumor index was calculated based on the number of tumor takes and the size of the tumors. the number of tumor cells was determined by comparis ... | 1976 | 1268858 |
| corynebacterium parvum. | | 1976 | 1269143 |