| the effect of hydrocortisone on the immune response of mice treated with corynebacterium parvum. | | 1976 | 776469 |
| enhancement of tissue invasion in murine aspergillosis by systemic administration of suspensions of killed corynebacterium parvum. | the effect of killed corynebacterium parvum vaccine on the course of murine aspergillosis is described. a grid-counting technique was employed to quantitate tissue invasion by aspergillus nidulans in the brain, heart, and kidneys (the target organs) of normal mice and of mice treated systemically with killed c. parvum vaccine. simultaneous treatment of mice with c. parvum and a. nidulans significantly increased the mortality rate, in contrast to treatment of mice with c. parvum prior to or follo ... | 1976 | 779492 |
| a modified plate holding system for anaerobic cultures. | a modified plate holding system for anaerobes has been developed which: 1) effectively reduces the volume of oxygen-free gas required, 2) promotes earlier bacterial growth, and 3) monitors the anaerobic atmosphere of the holding vessel and the rate of gas flow. cultures of bacteroides fragilis, clostridium perfringens, c. septicum, fusobacterium nucleatum, peptococcus sp. and propionibacterium sp. were evaluated for optimal growth. all cultures grew as well as or better when preincubated in the ... | 1976 | 782243 |
| augmentation of specific macrophage-mediated cytotoxicity: correlations with agents which enhance antitumor resistance. | | 1976 | 782731 |
| immunotherapy of cancer in man. | | 1976 | 786091 |
| combined treatment of rodent fibrosarcoma by radiotherapy and immune adjuvant. | | 1976 | 786964 |
| the immunobiology of colorectal cancer. | | 1976 | 793017 |
| immunotherapy of cancer in man: current status and prospectus. | | 1976 | 793477 |
| design of phase-i trials of immunopotentiators for cancer therapy: levamisole and corynebacterium parvum. | | 1976 | 793480 |
| characteristics of bacteria isolated by the anaerobic roll-tube method from cheeses and ground beef. | in this study the methods of hungate were used to quantitate the anaerobic bacteria present in commercially available ground beef, cheddar cheese, and german hand cheese. of 235 anaerobic roll-tube isolates from ground beef and german hand cheese, all were facultative anaerobes. of 213 anaerobic roll-tube isolates from cheddar cheese, 91% were facultative anaerobes and 9% were obligate anaerobes. using results of biochemical tests, 14 or the 17 obligately anaerobic isolates from cheddar cheese w ... | 1976 | 793523 |
| relationship between intradermal tumor suppression and tumor immunity. | intradermal (id) injection of three tumor-immune stimulant mixtures (lstra-bcg, 13762a-bcg, cad2-corynebacterium parvum) was superior to the sc site for suppression of tumor growth: suppression of lstra-bcg mixtures was even less efficient after an ip or iv injectiouppression at all four sites. in the lstra-bcg model, the id site was not uniquely favorable for either the afferent or efferent limb of the immune response; the other sites produced equally effectiveimmunization or rejection of tumor ... | 1976 | 794505 |
| tetrapyrrole biosynthesis: n-methyl-n'-nitrosoguanidine-induced mutants of propionibacterium shermanii. | | 1976 | 795726 |
| immunotherapy of gastrointestinal cancer: the potential. | | 1976 | 798647 |
| immunocompetence, immunodeficiency and prognosis in cancer. | immunocompetence and prognosis are related in solid tumors, malignant lymphomas, and acute leukemia. among the parameters of immunocompetence vigorous delayed-type hypersensitivity responses to recall antigens or to primary immunization with keyhole limpet hemocyanin, vigorous in vitro lymphocyte blastogenic responses to mitogens such as pha, and relatively high b-lymphocyte levels, all correlate with a good prognosis. the spectrum of immune reactivity as measured by established delayed-type hyp ... | 1976 | 800324 |
| biological activities of propionibacterium acnes from the human oral cavity--dermal toxicity and res-stimulating activity. | | 1976 | 802175 |
| a numerical taxonomic study of coryneform and related bacteria. | two hundred and thirty-three strains of coryneform bacteria, including representatives of the genera arthrobacter, brevibacterium, cellulomonas, corynebacterium, erysipelothrix, jensenia, kurthia, listeria, microbacterium, mycobacterium, nocardia and propionibacterium and other related bacteria, were studied using 173 morphological, physiological and biochemical tests. the bacteria were grown on a soil extract medium which allowed growth of all the strains, and all were incubated at 30 degrees c ... | 1975 | 805825 |
| effect of corynebacterium parvum on the course of a listeria monocytogenes infection in normal and congenitally athymic (nude) mice. | spleen counts of listeria monocytogenes in normal mice challenged with various numbers of organisms were generally lower in mice injected 3 days previously with killed corynebacterium parvum. this increased resistance was unexpected since c. parvum generally inhibits t cell-mediated immunity, the functional immunity against listeria being t cell-dependent. the inhibitory effect on t cells seemed to be compensated by the stimulatory effect of c. parvum on macrophages. therefore, the experiments w ... | 1975 | 808049 |
| potentiation of the tumor-specific immune response by corynebacterium parvum. | strong, specific, cell-mediated antitumor immunity resulted from the sc injection into mice of corynebacterium parvum (cp) mixed with irradiated cells from mastocytoma p815 (ma), whereas injection of irradiated ma alone was without effect. maximum immunity was achieved with small doses of cp, and the injection sites of cp and irradiated ma did not need to be coincident but required common lymphoid drainage for immunity to result. the process was largely t-cell dependent but not dependent on the ... | 1975 | 808637 |
| [effect of immunostimulation by corynebacterium parvum on evolution and metastatic dissemination of lewis's tumor in mouse c57bl/6 mice]. | treatment with corynebacterium parvum (c. parvum) produces a significant prolongation of survival time of lewis tumor bearing animals and reduces strikingly the incidence of pulmonary metastasis in syngeneic c57bl/6 mice. on the other hand, treatment with imuran, a known immunodepressive agent, reduces survival time and facilitates metastatic dissemination in the same model. | 1975 | 809167 |
| dichotomy between macrophage activation and degree of protection against listeria monocytogenes and toxoplasma gondii in mice stimulated with corynebacterium parvum. | in vivo and in vitro experiments were conducted to determine the effect of corynebacterium parvum treatment of mice on resistance of listeria monocytogenes and toxoplasma gondii. intravenous immunization with c. parvum conferred transient protection against intravenous challenge with listeria or an avirulent strain of toxoplasma but did not protect against a virulent strain of toxoplasma. compared with the level of protection conferred by c. parvum, a higher degree of resistance was noted when m ... | 1975 | 811563 |
| enhancement of resistance and suppression of immunization against experimental trypanosoma cruzi infection by corynebacterium parvum. | intravenous but not intraperitoneal injection of killed corynebacterium parvum either before or after intraperitoneal infection with the highly reticulotropic tulahuén strain of trypanosoma cruzi produced enhanced resistance against the infection in mice. in contrast, c. parvum had no effect when the infection was caused with the predominately myotropic y strain of t. cruzi. c. parvum given intravenously before immunization with killed culture forms of the y strain parasite consistently diminish ... | 1975 | 811568 |
| chemical and immunological studies on the cell walls of propionibacterium acnes strain c7 and corynebacterium parvum atcc 11829. | the chemical and immunological properties of the cell walls prepared from the cells of anaerobic coryneforms, propionibacterium acnes c7 and corynebacterium parvum atcc 11829, were partially investigated. the cell walls prepared from p. acnes c7 and c. parvum atcc 11829 were composed of fatty acids, polysaccharides consisting glucose, galactose and mannose and mucopeptides consisting mainly of alanine, glutamic acid, alpha, epsilon-diaminopimelic acid, glycine, muramic acid and glucosamine. as t ... | 1975 | 811835 |
| the effect of gold salts on tumour immunity and its stimulation by corynebacterium parvum. | the anti-inflammatory agent sodium aurothiomalate appears to act upon mononuclear phagocytes, inhibiting their lysosomal enzyme activity. evidence is presented that gold salts can increase the number of lung tumour nodules that develop following intravenous injection of tumour cells and pretreatment can enhance the take of a subcutaneous tumour inoculum. in contrast, they do not affect the later growth of tumour. gold salts can also suppress the action of systemically administered c. parvum in i ... | 1975 | 813755 |
| failure of corynebacterium parvum presensitization to modify the antitumor effects of systemic and local therapeutic injections of c. parvum in mice. | the therapeutic effects of iv and intralesional injection of corynebacterium parvum against mastocytoma p815 in mice, presentized and showing marked delayed hypersensitivity to c. parvum, were no different from those in unimmunized controls. | 1976 | 815560 |
| level of redox potential as a possible contributing influence in the pathogenicity of oral anaerobes. | dental plaque anaerobes may be associated with the etiology of periodontal disease. this has created an interest in the potential pathogenicity of oral anaerobes. we compared the metabolic activity of anaerobic corynebacteria (c. parvum, c. anaerobium) and corresponding aerobic species (c. diphtheriae, c. xerosis). the anaerobes exhibited lower levels of rna synthesis, ranging from 5 to 10 fold over the aerobes. we further examined these anaerobes, plus actinomyces naeslundi n16 (isolated from t ... | 1975 | 816253 |
| [effect of corynebacterium parvum on murine cultured bone marrow cells]. | the administration of corynebacterium parvum (c. parvum) stimulates in the mouse the bone marrow colony forming cell compartment in two stages. the first stage reaches pic values one day after two consecutive injections and the second, more important stage, reaches a pic at the 9th day which lasts over 27 days. there is no evidence that this effect is related to the liberation of csf. | 1976 | 816561 |
| effect of cytochalasin b on the adhesion of mouse peritoneal macrophages. | the adhesion of normal mouse macrophages to glass surfaces was reduced by nontoxic levels (1-50 mug/ml) of cytochalasin b in combination with a centrifugal force (1,000-8,000 g). macrophages nonspecifically activated by corynebacterium acnes were also detached by this treatment, but less effectively. the effects of cytochalasin b treatment on these cells were shown to be reversible. after detachment, the cells reattached to glass, appeared morphologically normal, and behaved like untreated cells ... | 1976 | 816801 |
| mitogenicity of corynebacterium parvum for mouse lymphocytes. | corynebacterium parvum, a powerful in vivo immunostimulant, is shown to stimulate lymphocyte proliferation in vitro. c. parvum is mitogenic for b lymphocytes and does not stimulate t cells. the mitogenicity is dependent on the presence of macrophages. c. diphtheriae and another strain of c. parvum, both of which are devoid of adjuvant, res stimulation, and tumour-inhibiting activities in vivo are nevertheless mitogenic. a lipid-free fraction from c. parvum, which retains in vivo immunostimulator ... | 1975 | 817854 |
| stimulation of the non-specific resistance by corynebacterium parvum and bacillus calmette guérin. | the effect of pretreatment of intravenously administered killed corynebacterium parvum (cp) and living bcg was studied in various model systems. both vaccines caused an increased resistance to listeria monocytogenes, indicating macrophage activation. only cp exerted a suppressive effect on t-cell-mediated immunological phenomena (skin allograft survival; antibody production to tetanus toxoid; expulsion of adult t. spiralis worms from intestine). results of experiments with congenitally athymic ( ... | 1976 | 821172 |
| the effects of activated macrophages on tumor target cells: escape from cytostasis. | | 1976 | 821620 |
| [new concept of the taxonomic position of anaerobic corynebacteria]. | the new phenotypic and genotypic characteristics of the anaerobic coryneforms allow us to individualize them in a new sub-genus: coryneformis nv. sub-gen so defined: corynebacteriaceae with morphology of true corynebacterium from which they differ by pathogenicity, the ability to synthesize reticulo-stimulin, their cell-wall composition, thier g + c%, their anaerobic growth and their salmon-pink colonies. they differ also from the true propionibacterium which are not pathogenic, do not synthesiz ... | 1976 | 821638 |
| mitogenic activity of the cell walls of mycobacteria, nocardia, corynebacteria and anaerobic coryneforms. | the mitogenic activity of the cell walls prepared from mycobacterium bovis bcg, nocardia rubra, corynebacterium diphtheriae pw8, and four species of propionibacterium, corynebacterium parvum atcc 11829, propionibacterium acnes c7, propionibacterium granulosum atcc 25564 and propionibacterium avidum atcc 25577, were investigated. these cell walls were active as mitogens on normal spleen cells, anti-o sera-treated spleen cells, macrophage-depleted spleen cells of c57bl/6j mice and cortisone-treate ... | 1976 | 824484 |
| glycerol dissimilation and its regulation in bacteria. | | 1976 | 825019 |
| [immunization by canadida albicans and non-specific immunostimulation by corynebacterium granulosum and bcg in experimental candidiasis]. | immunostimulation by corynebacterium granulosum (whole bacteria or a delipided fraction p40) or by live bcg enhanced the resistance of lethally infected mice by candida albicans. the protection is greater by association with an active specific immunization by various preparations of c. albicans. | 1976 | 825252 |
| immunochemistry of the subunits of transcarboxylase. | antisera reactive with the subunits of transcarboxylase were produced by injecting rabbits with the 12 sh and 5 se subunits prepared from trypsin-treated enzyme and with the 12 sh subunit prepared from native transcarboxylase by avidin-sepharose chromatography. biotinyl peptides (46 and 65 amino acid residues), released from the enzyme by brief trypsin treatment, formed complexes with avidin and this noncovalent conjugate was used as an antigen to prepare antibodies reactive with the 1.3 se biot ... | 1976 | 825513 |
| interaction of tumor cells and activated macrophages in vitro: modulation by corynebacterium parvum and gold salt. | | 1976 | 825644 |
| antitumor antibodies and immunoglobulin class and subclass levels in corynebacterium parvum-treated mice. | changes in immunoglobulin class and subclass levels and the development of antitumor antibodies were assessed in normal and tumor-bearing mice challenged with corynebacterium parvum. c. parvum administration resulted in a marked increase in certain immunoglobulin levels, especially ig g2b, and in the development of antibodies reacting with syngeneic and allogeneic tumor cells. the serologic changes induced by c. parvum were dependent on the dose and route of administration; preliminary studies s ... | 1976 | 825650 |
| specific and nonspecific antitumor immunity. iii. specific t lymphocyte-mediated cytolysis of p815 mastocytoma and sl2 lymphoma by draining lymph node cells from syngeneic tumor-bearing dba/2j mice. | tumor-specific cytolytic activity, as measured by the 51cr release assay, has been demonstrated in the draining lymph node cells from dba/2 mice bearing the syngeneic p815 mastocytoma or sl2 lymphoma. this lytic activity is mediated by cytolytic t lymphocytes (ctl), since cytotoxicity is eliminated by treatment of the effector cells with anti-thy 1.2 (theta) serum plus complement but is enhanced or unaffected by anti-thy 1.2 serum alone, antimouse immunoglobulin plus complement, normal or aggreg ... | 1976 | 826167 |
| [comparative study of biological activities among bacterial strains of anaerobic coryneforms and propionibacteria]. | | 1976 | 826671 |
| organ distribution of corynebacterium parvum labeled with iodine-125. | administration of iv, ip, single sc, multiple sc, and footpad injections of [125i]corynebacterium parvum in mice revealed different patterns of radioactive vaccine distribution in various organs. high deposition and retention were found in the liver, spleen, and gastrointestinal tract and less in the lungs, kidneys, thymus, and bone marrow. control animals given 125i showed very rapid clearance of the isotope and no retention in the organs. the pattern of distribution of [125i]c. parvum could be ... | 1977 | 833877 |
| systemic therapy for metastatic breast cancer. | the data reviewed in this conference suggest that initial therapeutic decisions for patients with metastic breast cancer be based on the presence or absence of an estrogen receptor in the tumor. patients with estrogen receptor in their original primary breast cancer or in a subsequent metastitic lesion are candidates for hormonal manipulation, whereas patients lacking estrogen receptor in their tumor are treated for their metastic disease with nonhormonal chemotherapy. nonhormonal therapy usuall ... | 1977 | 835932 |
| susceptibility of propionibacterium acnes to seventeen antibiotics. | the in vitro susceptibility of 96 isolates of propionibacterium acnes to 17 antibiotics was determined by utilizing an agar dilution technique. with the exception of the aminoglycosides, these organisms are susceptible to virtually all of the commonly used antimicrobial agents. | 1977 | 836012 |
| isolation and identification of fecal bacteria from adult swine. | an examination of the fecal microflora of adult swine was made with regard to the efficiency of several roll tube media in enumeration and recovery of anaerobes, the effects of medium constituents on recovery, and the isolation and identification of the predominant kinds of bacteria. total number of organisms by microscopic bacterial counts varied among fecal samples from 4.48 x 10(10) to 7.40 x 10(10) bacteria/g (wet weight). comparison of different nonselective roll tube media indicated that a ... | 1977 | 836025 |
| intravenous corynebacterium parvum: an adjunct to chemotherapy for resistant advanced ovarian cancer. | this is a prelimianry report of an effort to treat women with advanced (stage iii and iv) ovarian cancer who had progressive disease in spite of previous surgery, chemotherapy and/or radiation by a program of reductive surgery, intensive immune stimulation and combination chemotherapy. an initial laparotomy was done where possible to reduce tumor burden, and then all patients were given intravenous corynebacterium parvum (c.p.) in escalating doses over a 10- to 14-day period. cyclic chemotherapy ... | 1977 | 837334 |
| in vitro and in vivo cytotoxicity of adriamycin and daunomycin for murine macrophages. | in virto exposure of murine lymphoma cells to adriamycin and daunomycin (dm) for 24 hr resulted in comparable cytotoxicity as assessed by viable cell counts and inhibition of dna synthesis. the spontaneous dna synthesis of spleen lymphocytes in vitro was also equally affected by the two agents. however, when the in vitro effects of the two drugs on macrophage monolayers were investigated, dm was found to be at least four times more toxic than am. in vivo-administered dm was more suppressive than ... | 1977 | 837378 |
| electron microscopy of the large form of transcarboxylase with six attached subunits. | in this paper we show that the native form of transcarboxylase may be a species which has six rather than three subunits attached to the central subunit. we have designated this form as the 26 s enzyme. electron micrographs support the view that the six subunits are attached in sets of three at the opposite faces of the central subunit, in contrast to the 18 s form in which all three subunits appear to be attached only at one face. in addition, evidence is presented that the dissociation of the ... | 1977 | 838726 |
| chemoattractant properties of corynebacterium parvum and pyran copolymer for human monocytes and neutrophils. | both pyran copolymer and the burroughs-wellcome vaccine of corynebacterium parvum were able to elicit a migratory response by human neutrophils or monocytes when incubated with serum. however, in the absence of serum, neither agent elicited such a response. the generation of the chemotactic factor by pyran was dependent on heat-labile components in the serum, while suggested involvement of the complement sequence. conversely, the migratory response of c. parvum in heated serum was equivalent to ... | 1977 | 839571 |
| the influence of nonspecific immunotherapy on the course of murine melanoma. | bcg, corynebacterium parvum, vitamin a, and levamisole were continuously administered to c57 bl/6 mice bearing b16 melanoma prior to, with following tumor implantation as well as before and coincident with surgical excision of the implanted tumor. only the group given levamisole prophylactically for 8 weeks before tumor inplantation showed a significant difference from control mice but a tenfold increase in dosage in this drug did not exert a comparable effect. | 1977 | 839793 |
| corynebacterium parvum and cyclophosphamide as combination treatment for a murine mammary adenocarcinoma. | weekly i.p. injections of killed corynebacterium parvum and of cyclophosphamide (given on different days) strongly inhibited growth of a transplantable murine mammary adenocarcinoma. a significant portion (40 to 80%) of animals could be made tumor free by means of combined therapy. no tumor-free survivors were obtained with c. parvum alone, and tumor-free mice were obtained with cyclophosphamide alone only at the expense of a high incidence of deaths due to drug toxicity. no evidence of tumor re ... | 1977 | 844041 |
| [susceptibility to thiamphenicol and chloramphenicol of anaerobic bacteria (author's transl)]. | the in vitro susceptibility to thiamphenicol and chloramphenicol of 272 anaerobes, most of which were recent clinical isolated, was determined by broth dilution tests, with chloramphenicol, 133 anaerobic gram-negative non-sporing rods (48 bacteroides fragilis, 13 b. thetaiotaomicron, 14 b. oralis, 16 sphaerophorus varius etc.) had mic values of 0.03 through 16 microng/ml. very similar results (mic, 0.06-16 microng/ml) were obtained with thiamphenicol. in concentrations of 4 microng/ml or less ch ... | 1977 | 848218 |
| anaerobic bacteria in otitis media. | anaerobic bacteria, peptostrepotococcus intermedius and propionibacterium acnes, were found in mixed culture specimens from four to ten tested cases of chronic secretory otitis media. these anaerobic bacteria were in a mixed infection flora with aerobic bacteria most often staphylococcus epidermidis and cornybacterium sp. which do not fit any established species. the findings of anaerobic bacteria in otitis media is consistent with the sporadic report of the involvement of anaerobic bacteria in ... | 1977 | 848830 |
| increased spreading of macrophages from mice treated with interferon inducers. | | 1977 | 849607 |
| radiolabelling of corynebacterium parvum and its distribution in mice. | corynebacterium parvum was labelled by growing live bacteria in the presence of [3h]thymidine. the bacteria were killed by formalin, washed thoroughly and resuspended at a concentration of 7 mg dry weight/ml. an activity of 1-6 x 10(5) ct/min/0-1 ml was obtained. the biological properties (inhibition of tumour growth and hepatosplenomegaly) of the labelled c. parvum were compared with those of commercially available vaccine, and were found to be similar. labelled c. parvum was injected i.v., i.p ... | 1977 | 851511 |
| immunology of lung cancer. | | 1977 | 852345 |
| susceptibility of anaerobic bacteria to metronidazole, ornidazole, and tinidazole and routine susceptibility testing by standardized methods. | a total of 114 strains of anaerobic bacteria were examined for their susceptibility to metronidazole, ornidazole, and tinidazole by measuring the minimum inhibitory concentration (mic) and minimum bactericidal concentration in different media. all strains, with the exception of the isolates of propionibacterium acnes, were inhibited by 3.1 mug each and killed by 6.3 mug each of all three nitroimidazole compounds per ml. no significant differences in mic values were found among metronidazole, orn ... | 1977 | 856015 |
| [on cobyrinic acid biosynthesis. novel methylated hydroporphyrins and their role in cobyrinis acid formation (author's transl)]. | clostridium tetanomorphum and propionibacterium shermanii were examined for intermediates in the synthetic pathway uroporphyrinogen iii leads to cobyrinic acid. the isolation of two novel methylated hydroporphyrins, whose methyl groups are derived from s-adenosyl-l-methionine, is described. spectroscopic (field desorption-mass, visible absorption) und electrophoretic studies as well as incorporation of labelled substrates indicate that they are analogues of a dihyrouroporphyrin and a tetrahydrou ... | 1977 | 856710 |
| a numerical taxonomic survey of listeria and related bacteria. | a numerical taxonomic study was performed on named strains of listeria, erysipelothrix, microbacterium thermosphactum, lactobacillus, streptococus, propionibacterium, kurthia and some possibly related bacteria using i43 unit characters covering a wide range of properties. the strains fell into six main clusters: (a) listeria; (b) microbacterium thermosphactum, lactobacillus, streptococcus; (c) gemella, erysipelothrix; (d) kurthia and mainly aerobic corynebacteria; (e) propionibacterium, staphylo ... | 1977 | 856940 |
| effects of c. parvum on growth and induction of intracerebral tumours in mice. | an investigation was made into the effect of corynebacterium parvum therapy on cerebral tumours in mice. i.v. c. parvum caused a slight but significant increase in the survival of balb/c mice injected intracerebrally (i.c.) with not more than 50 meth a cells. c. parvum was most effective if given on the same day or 5 days after tumour. if this interval was increased there was no effect. multiple i.v. injections were no more effective than a single dose. i.v. c. parvum had no influence on the sur ... | 1977 | 857825 |
| serological changes associated with c. parvum treatment in nude mice. | | 1977 | 861151 |
| effect of c. parvum and active specific immunotherapy on intracerebral transplants of a murine fibrosarcoma. | | 1977 | 861152 |
| combined treatment with anaerobic corynebacterium liquefaciens and chemotherapeutics against solid tumor in mice. | the combined effect of anticancer agents (mitomycin-c, cyclophosphamide, or 5-fluorouracil) and anaerobic corynebacterium liquefaciens on subcutaneously induced solid ehrlich carcinoma in mice was examined. mitomycin-c and cyclophosphamide were given intraperitoneally on day 7 after inoculation of tumor cells. 5-fluorouracil was administered intraperitoneally for 7 consecutive days from day 9 to 15. c. liquefaciens was given in two ways, intraperitoneally and intratumorally. its injections were ... | 1977 | 863171 |
| an analysis of the factors allowing promotion (rather than inhibition) of tumour growth by corynebacterium parvum. | the following factors were found to determine whether c. parvum (cp) treatment promoted rather than inhibited the growth of methylcholanthrene-induced fibrosarcoma cells injected into cba mice. (1) the dose of tumour cells. promotion occurred only with low doses, around the td50. (2) the route of injection of cp. greater promotion was caused by intravenous (iv) than by subcutaneous (sc) administration. addition of irradiated tumour cells to sc cp resulted in tumour inhibition. (3) the dose of cp ... | 1977 | 863546 |
| effect of corynebacterium parvum, methanol-extraction residue of bcg, and levamisole on macrophage random migration, chemotaxis, and pinocytosis. | three parameters of macrophage function: random migration, chemotaxis, and pinocytosis, were studied in the guinea pig after administration of corynebacterium parvum, methanol-extraction residue of bcg, and levamisole (lms), a synthetic anthelmintic. macrophage migration studies were performed with a modified boyden chamber. pinocytosis was assessed by the uptake of colloidal 198au. after ip administration, each of the three immunostimulators induced an increase in macrophage chemotactic respons ... | 1977 | 864753 |
| [role of ammonium nitrogen in the biogenesis of vitamin b12 by propionibacterium shermanii]. | the effect of different nitrogen sources on the biosynthesis of vitamin b12 ano porphyrins by suspensions of resting cells of propionibacterium shermanii was investigated. in the absence of ammonium nitrogen vitamin b12 was not accumulated by the bacterial cell. this was also the case when its nitrogen containing precursor--delta-aminolevulinic acid was added to the incubation medium. the porphyrins biosynthesis was not changed. when amino acids and their amides were used as the sole nitrogen so ... | 1977 | 866297 |
| association-dissociation of transcarboxylase. | transcarboxylase consists of a central subunit to which two sets of three subunits each are attached at opposite faces. evidence obtained by various ultracentrifugal techniques has shown that there is an equilibrium between active forms of the enzyme with six, five, four, three, two, and one subunits attached to the central subunit. since each attached subunit contains two biotins, the biotin content of these forms varies from 12 to 2. by reactive enzyme sedimentation at ph 5.5, it has been show ... | 1977 | 870031 |
| the distribution and persistence in vivo of corynebacterium parvum in relation to its antitumor activity. | killed corynebacterium parvum was labeled with fluorescein isothiocyanate or 125i, and both preparations were shown to retain lymphoreticular stimulatory and antitumor activity. large amounts of c. parvum injected i.v. were found in the liver, spleen, and lungs with less in bone marrow and lymph nodes. apart from a rapid loss from the lungs within 24 hr, the persistence of killed c. parvum was striking, and some intact bacteria were still detectable in the liver and spleen at 15 days. (by contra ... | 1977 | 870181 |
| antibody to corynebacterium parvum in normal human and animal sera. | using a microtiter bacterial agglutination test, we have estimated antibodies to corynebacterium parvum in "normal" human and "normal" and immune animal sera. widely differing levels of c. parvum antibodies were found in the normal human sera. the median titer for all 310 human sera was 1:128, whereas that for the 1- to 17-year and 18- to 50-year subgroups was 1:64 and 1:512, respectively. antibody titers in the various animal species were generally much lower. | 1977 | 870426 |
| the functioning of cytochrome b in the electron transport to furmarate in propionibacterium freudenreichii and propionibacterium pentosaceum. | fumarase-free electron particles from propionibacterium freudenreichii and p. pentosaceum were prepared by discontinuous sucrose gradient centrifugation, and the influence of 2-n-heptyl-4-hydroxy-quinoline-n-oxide (hqno) and ultraviolet irradiation on the reduction of menaquinone and cytochrome b with l-lactate or glycerol-3-phosphate and the reoxidation by fumarate was studied. in the presence of hqno the steady state reduction level of menaquinone during fumarate reduction was increased wherea ... | 1977 | 871228 |
| comparative effect of anaerobic coryneforms on a murine melanoma. | ten strains of anaerobic corynebacteria were compared in their effect on survival of c57bl/6 mice, bearing subcutaneously inoculated b16 melanomas. the corynebacterial suspensions were injected intralesionally twice weekly for five injections. significant permanent tumor regression was not obtained. significant prolongation of survival was observed in mice treated with seven of the corynebacterial strains. | 1977 | 872039 |
| cell-mediated immunity and serum blocking factors in cancer patients during chemotherapy and immunotherapy. | the leukocyte adherence inhibition test was used to monitor tumor-specific cell-mediated immunity in 15 patients who had a variety of malignant tumors and were undergoing chemotherapy alone or in combination with immunotherapy by corynebacterium parvum. a rapid and prolonged loss of cell-mediated immunity in blood leukocytes was observed after treatment in all but one of the patients studied. abolition of reactivity was due to the lack of production of the soluble lymphokine-like factor affectin ... | 1977 | 872076 |
| separation and characterization of epithelial cells from prostates and prostatic carcinomas: a review. | our investigation of normal, hyperplastic, and neoplastic prostatic tissue during the past 2 1/2 years has produced several findings which have been published or accepted for publication. (a) cells from hamster prostates with intense histochemically demonstrable acid phosphatase activity (hdap) after fixation with formaldehyde which we believe to be epithelial cells can be obtained in 97.2% +/- 0.8% purity by velocity sedimentation in a previously described isokinetic density gradient; (b) simil ... | 1977 | 872127 |
| immunological response in patients receiving corynebacterium parvum therapy. | | 1977 | 872468 |
| corynebacterium parvum-induced radiosensitivity and cycling changes of hematopoietic spleen colony-forming units. | ten days after total-body irradiation with 550 rads of b0co, spleen colonies were observed in adult c57bl mice. a change in radiosensitivity induced by corynebacterium parvum, as measured by increased numbers of colony-forming units that survived the 550 rads, began shortly after c. parvum stimulation and extended for at least 7 days before irradiation. c. parvum given 4-24 hours before, followed by high specific activity [3h]thymidine (hsatt) 1 hour before total-body irradiation greatly reduced ... | 1977 | 875052 |
| effect of nitrate reduction on metabolic products and growth of propionibacterium acidi-propionici. | | 1977 | 878501 |
| propionibacterium acnes meningitis in a previously normal adult. | a 25-year-old man was previously healthy until he contracted acute propionibacterium acnes meningitis. comparison with previous reports of de novo diphtheroid meningitis suggests that this entity can appear with features that are not characteristic of acute bacterial meningitis, including (1) stroke-like syndromes, (2) an afebrile course, and (3) a cerebrospinal fluid with a mononuclear pleocytosis and normal glucose level. the appropriate choice and dosage of antimicrobial agent must be guided ... | 1977 | 879934 |
| modulation of host immune response against the l2c guinea pig leukemia. | | 1977 | 885264 |
| host immunological mechanisms in the resistance of mice to leptospiral infections. | several serovars of leptospira virulent for hamsters and guinea pigs caused acute lethal leptospirosis in mice immunosuppressed with cyclophosphamide. neither bcg vaccine nor corynebacterium parvum suspension influenced the course of leptospiral infection in either immunosuppressed or normal balb/c mice. nude athymic mice produced anti-leptospiral antibody and were therefore resistant to infection with leptospires. nude mice were made susceptible with cyclophosphamide but were immune if they had ... | 1977 | 885617 |
| an adenylate cyclase of brain reflects propensity for breast cancer in mice. | high propensity for breast cancer in mice was associated with low dopamine-stimulated adenylate cyclase activity in the brain, low spontaneous motorization, and low motor responses to injections of the catecholamine precursor, l-dopa. | 1977 | 887942 |
| intravascular coagulation resulting from intravenous injection of c. parvum in mice. | in mice, i.v. c. parvum induces intravascular coagulation. this is a prolonged reaction lasting up to 7 days. it results in thrombosis in hepatic vessels with consequent hepatic necrosis, and thrombosis in pulmonary and splenic vessels. this may be important in the assessment of the tumour-inhibitory activity of c. parvum. | 1977 | 889682 |
| mechanism of the anti-tumour effect of glucans and fructosans: a comparison with c. parvum. | the anti-tumour activity induced by glucans (lentinan, yeast cell walls, pseudonigeran, dextran, deae-dextran and dextran sulphate) and fructosans (levan and carboxymethyl-levan) was compared with the activity of c. parvum. the following effects on tumour systems in cba mice were assayed: (a) adjuvant activity on the immune response against tumour-specific transplantation antigens (tsta) with a methylcholanthrene-induced fibrosarcoma; (b) cytostatic activity of peritoneal macrophages against rad ... | 1977 | 889684 |
| biosynthesis of vitamin b12. formation of free 5,6-dimethylbenzimidazole and alpha-ribazole from riboflavin by propionibacterium freudenreichii. | | 1977 | 891984 |
| comparative study of corynebacterium parvum and corynebacterium liquefaciens on antitumor activity against sarcoma-180. | corynebacterium parvum and corynebacterium liquefaciens were comparatively examined for their antitumor activity against sarcoma-180 in ddy mice. in the case of ascitic form, significant antitumor effect was observed when c. parvum was administered on days -4 and -2 or day -2. as for solid form, maximal effect was obtained when c. parvum was administered on day 0. on the other hand, c. liquefaciens exhibited maximal antitumor activity against sarcoma-180, both in ascitic and solid forms, when it ... | 1977 | 892298 |
| effect of immunomodulators on effector cells involved in antibody-dependent cellular cytotoxicity: brief communication. | the effect of four immunomodulators (bcg, corynebacterium parvum, pyran copolymer, and levamisole) on the cellular arm of antibody-dependent cellular cytotoxicity (adcc) was investigated in mice with 51cr-labeled chicken erythrocytes employed as targets. all these drugs, except levamisole, stimulated the effector cells of adcc in the spleen, but the kinetics of their effect differed. stimulation of the effector cells of adcc peaked on day 15 after injection of bcg and c. parvum and on day 7 afte ... | 1977 | 894742 |
| combined radiotherapy and corynebacterium parvum treatment of a murine fibrosarcoma. | a single dose of corynebacterium parvum (cp) at 70 microgram, 175 microgram or 350 microgram was effective in suppressing the growth of a subcutaneous fibrosarcoma and occasionally in inducing complete regression and in prolonging the survival time of c3h/hej tumor-bearing mice. a single exposure of x rays at 2,000 rads induced some complete regression, but a higher number of complete regressions was induced by combined x-ray and cp treatment. in the combined x-ray and cp treatment, cp given on ... | 1977 | 897175 |
| bacteriology of cholesteatoma: clinical significance. | | 1977 | 898521 |
| [effect of corynebacterium parvum on various viral infections in the mouse]. | | 1977 | 900789 |
| local control and disease-free survival after treatment of a squamous cell carcinoma by corynebacterium parvum and local irradiation. | | 1977 | 908026 |
| efficacy of corynebacterium parvum treatment of mice with sarcoma growing in normal or irradiated tissue. | | 1977 | 908052 |
| in vitro activity of five oral cephalosporins against anaerobic pathogenic bacteria. | the in vitro inhibitory activities of cefaclor and and cefatrizine, two new orally absorbed cephalosporin antibiotics, against 44 isolates of anaerobic pathogenic bacteria were measured using the agar dilution procedure of the world health organization-international collaborative study. tests also were performed with cephalexin, cephaloglycin, and cephadrine, as well as with the parenteral cephamycin antibiotic cefoxitin. cefoxitin was the most active antibiotic and inhibited the majority of iso ... | 1977 | 915342 |
| increase of phagocytic activity and new appearance of a c4b (guinea pig) recognizing capability in peritoneal macrophages from corynebacterium parvum and thioglycollate-stimulated mice. | activated mouse macrophages displayed enhanced phagocytic activity towards particles opsonized with igg antibody and homologous c3. in addition, they were able to recognize guinea pig c4b. it is concluded that activated macrophages develop phagocytically active receptors for heterologous c4b. | 1977 | 917013 |
| investigations on prostatic adenocarcinomas in rats. | metastatic prostate adenocarcinomas, derived from aging germfree wistar rats, have been propagated in rats and in tissue culture. a protocol has been developed and demonstrated for assay of treatments which retard or which accelerate the rate and extent of tumor growth and of metastasis in tumor-bearing rats. the pattern of spread has been retarded by cyclophosphamide, aspirin, indomethacin, and corynebacterium parvum. the spread pattern has been accelerated by oral administrations of sodium bar ... | 1977 | 917442 |
| effects of corynebacterium parvum on tumour metastases in mice. | | 1977 | 922293 |
| [on the preparation of intermediates in cobyrinic acid biosynthesis by suspensions of propionibacterium shermanii (author's transl)]. | the preparation of a dimethyltetrahtdrouroporphyrin (faktor ii or sirohydrochlorin) using suspensions of propionibacterium shermanii as well as a promising method for the isolation of tetrapyrrols with at least four carboxy substituents from cell-free extracts and growth media are described. also a faktor ii-analogue with three methyl groups which are derived from l-methionine is reported. incorporation experiments indicate that this is an intermediate in cobyrinic acid formation. because of thi ... | 1977 | 924361 |
| expression of a new cell surface antigen on activated murine macrophages. | a macrophage cell-surface antigen associated with pyran and corynebacterium parvum-activated macrophages and p388d1 cells but not detectable on normal or glycogen and thioglycollate-elicited murine macrophages has been described. the antigen was demonstrated both by complement-mediated cytotoxicity and immunofluorescence, using an appropriately absorbed rabbit antiserum to p388d1. this antiserum should enable the characterization of activated macrophage cell populations on an individual cell bas ... | 1977 | 925608 |
| effects of oxygen on propionibacterium shermanii grown in continuous culture. | growth yields, enzyme activities, cytochrome concentrations and the rates of product formation were determined in propionibacterium shermanii cultures grown in a chemostat with lactate as the energy source at various concentrations of oxygen. oxygen was toxic when its partial pressure in the inflowing gas was just sufficient to give measurable dissolved oxygen concentration in the culture, when it inhibited lactate oxidation and nadh oxidase activity. below this oxygen concentration, p. shermani ... | 1977 | 925678 |
| paradoxical effects of immunopotentiators on tumors and tumor viruses. | growth of tumors was inhibited or enhanced in mice by a synthetic (pyran) or a biologic (corynebacterium parvum) immunopotentiator. marked inhibition of leukemogenesis induced by friend leukemia virus was produced by prophylactic intraperitoneal treatment with pyran, while intravenous treatment with pyran (in the same dose and regimen) significantly enhanced growth of tumor virus. paradoxical effects were also seen with the biologic immunopotentiator c. parvum in solid tumor systems. treatment w ... | 1976 | 932503 |
| anaerobic bacteria from the large intestine of mice. | anaerobic bacteria from the colon of laboratory mice were enumerated and isolated using strict anaerobic techniques. direct microscopic counts revealed 4.4 x 10(10) organisms in each gram (wet weight) of colon contents. actual cultural counts averaged 3.2 x 10(10) organisms, which was 73% of the direct microscopic count. the tentatively identified genera were bacteroides, eubacterium, fusobacterium, lactobacillus, peptostreptococcus, and propionibacterium. strains of fusobacterium, lactobacillus ... | 1976 | 938042 |
| comparative study of two systems for detecting becteraemia and septicaemia. | two blood culturing systems were compared in parallel-a semi-automated radiometric method, bactec1, and the conventional method used in our laboratory. bactec contains radioactive 14c labelled substrates and monitors the level of 14co2 evolved by actively metabolizing bacteria. bactec was as efficient as the conventional method in detecting positive cultures and indicated that it was superior in detecting positive cultures earlier than the conventional system. | 1976 | 939807 |
| study of the mechanism of corynebacterium parvum anti-tumour activity. i. protective effect on the growth of two syngeneic tumours. | the protective effect of c. parvum against two different tumours - a lymphosarcoma and a mammary carcinoma - has been demonstrated. in the case of lymphosarcoma, a significant protective effect was obtained when both c. parvum and tumor cells were injected iv. in contrast in c3h mice the best protection was obtained when both c. parvum and mammary carcinoma cells were injected ip. thus both c. parvum and tumour cells must be inoculated by the same route which, however, varies for different tumou ... | 1976 | 946965 |
| observations following corynebacterium parvum administration to patients with advanced malignancy. a phase i study. | there has been increasing interest regarding the use of corynebacterium parvum (cp) with other modalities in the management of primary cancer. due to the paucity of specific information available relative to cp toxicity, a phase i study was carried out in patients with advanced disease. the purpose of the investigation was not to evaluate the effect of cp on tumor growth. from 273 injections of cp in 40 patients it was observed that following intravenous (i.v.) infusion of cp: a) a febrile respo ... | 1976 | 947509 |