| [bacterial coincidence in the infected middle ear and nasopharynx (author's transl)]. | | 1979 | 41890 |
| [a clinical observation of cefuroxime in pediatric field (author's transl)]. | cefuroxime, a new synthetic cephalosporin, was administered to 10 pediatric patients (6 with respiratory tract infection, 2 with urinary tract infection, 1 with sepsis of e. coli and 1 with enterocolitis). the clinical result was good and excellent in all the 10 cases. no side effect was observed in any of them. | 1979 | 41955 |
| the amino acid sequence of a variable region of rabbit b4 chain from an anti-siii antibody: comparison with light chains of the same sub-group from anti-a-variant carbohydrate antibodies. | | 1979 | 42017 |
| antimicrobial treatment of otitis media. | | 1979 | 42033 |
| evidence of breakdown of pneumococcal polysaccharides in vivo. | | 1979 | 42073 |
| [acute otitis media complicated by meningitis]. | | 1979 | 42184 |
| immunoprophylaxis of pneumococcal pneumonia. | | 1979 | 42222 |
| [discrete nature of the frequency of recombinations in bacterial transformation systems]. | | 1979 | 42234 |
| [leukocidins of coccal microorganisms]. | | 1979 | 42241 |
| pneumococcal vaccine. | | 1979 | 42308 |
| pneumococcal infections after human bone-marrow transplantation. | seven of 26 long-term survivors (greater than 7 months post-transplant) of bone-marrow transplantation developed penicillin-sensitive pneumococcal infections more than 7 months after transplantation. one patient had two infections. six of eight infections were associated with pneumococcal bacteremia, and streptococcus pneumoniae type 6a was isolated in three cases. two infections were fatal. all patients had normal nematopoietic function, and none was receiving immunosuppressive therapy. the dev ... | 1979 | 42335 |
| a controlled study of pneumococcal polysaccharide vaccine in systemic lupus erythematosus. | the immunogenicity and potential for disease modification of pneumococcal polysaccharide vaccine in systemic lupus erythematosus were evaluated in a controlled, double-blind study. forty patients were randomly chosen to receive an intramuscular injection of either vaccine or placebo. changes in mean antibody concentrations (nanograms antibody nitrogen per milliliter serum) to 12 type-specific pneumococcal capsular antigens from prevaccination to one month after vaccination were 177 to 1045 in th ... | 1979 | 42410 |
| the synthesis of part of the repeating unit of a pneumococcal polysaccharide. | | 1979 | 42481 |
| should we plan a general childhood vaccination against bacterial meningitis? | an estimation of the benefits of vaccination against bacterial meningitis are based on the age-specific incidence of meningitis caused by the different groups of meningococci, by haemophilus influenzae and by pneumococci, and the known efficacy of the present polysaccharide vaccines against these agents. since the incidence of bacterial meningitis is more than ten times higher below the age of five years that at a later age, vaccination at 1 1/2 years of age could prevent a large fraction of all ... | 1979 | 42596 |
| functional assay of the alternative complement pathway of rat serum. | | 1979 | 42660 |
| [etiologic diagnosis of pneumoccocal pneumonia by counterimmunoelectrophoresis (author's transl)]. | the antigenic composition of the pneumoccocal capsule and its easy detection by counterimmunoelectrophoresis led us to carry out a comparative study of this method and the results obtained from cultures. a series of 159 patientes with suspected bacterial pneumonia were included in the study. blood cultures were prepared for all of the patients; sputum cultures were practiced on 35 and cultures of pleural fluid on 32. serum from all of the patients, urine from 104, sputum from 34, and pleural flu ... | 1979 | 42833 |
| [clinical aspects and importance of pneumococcal pneumonia]. | | 1979 | 42848 |
| [the bacteriological diagnosis of pneumonia by transtracheal puncture. value in medical intensive care (author's transl)]. | seventy five patients referred with a diagnosis of pneumonia underwent transtracheal puncture. in 76% of cases this examination led to discovery of an organism in infected patients. in 50% of cases, the bacteriological diagnosis was sufficiently accurately oriented by direct examination to permit rapid and effective treatment. there was virtually perfect agreement with the results of blood cultures when the latter were positive. the organisms most often responsible were gram positive and above a ... | 1979 | 42881 |
| sensitivity to androgen. a possible factor in sex differences in the immune response. | | 1979 | 43206 |
| activation of the classical complement pathway by homogeneous anti-siii antibody bound to bivalent or trivalent oligosaccharide antigens. | | 1979 | 43279 |
| opsonic activity of normal human cerebrospinal fluid for selected bacterial species. | the opsonic activity of normal human cerebrospinal fluid (csf) has not been well defined. in this study, the opsonic activity of normal csf for laboratory and blood culture isolates of staphylococcus aureus, streptococcus pneumoniae, escherichia coli, hemophilus influenzae type b, and neisseria meningitidis was measured by a quantitative assay employing radiolabeled bacteria and polymorphonuclear leukocytes. all isolates of s. aureus, except the wood 46 strain, were opsonized in undiluted csf (> ... | 1979 | 43289 |
| comparative immunogenicity of group 6 pneumococcal type 6a(6) and type 6b(26) capsular polysaccharides. | the comparative immunogenicity of the two cross-reacting group 6 pneumococcal capsular polysaccharides, type 6a(6) and type 6b(26), was studied with hyperimmune rabbit typing antisera and with sera from adult volunteers injected with polyvalent pneumococcal vaccines containing either 50 mug of type 6a (u.s. designation, type 6) or 50 mug each of type 6a and type 6b (u.s. designation, type 26) polysaccharides. both group 6 polysaccharides were linear copolymers composed of 1 mol each of d-galacto ... | 1979 | 43290 |
| enzyme-linked immunosorbent assay for measurement of antibodies against pneumococcal polysaccharide antigens: comparison with radioimmunoassay. | an enzyme-linked immunosorbent assay (elisa) for measuring antibodies against each of 14 polysaccharides in contemporary pneumococcal vaccine is described, and the findings of tests of paired sera from vaccinated human subjects are compared with those obtained by radioimmunoassay. the findings were in very poor agreement, and this appears to be due to the lesser ability of the elisa procedure to measure antibody of low avidity. the elisa procedure described here is not considered to be a satisfa ... | 1979 | 43335 |
| experimental otitis media in chinchillas following nasal colonization with type 7f streptococcus pneumoniae: prevention after vaccination with pneumococcal capsular polysaccharide. | chinchillas were colonized intranasally with type 7f streptococcus pneumoniae, and pneumococcal otitis media developed in greater than 50% of the animals during the first week after negative middle ear pressure (-25 mm hg) was briefly applied. twenty-three chinchillas were vaccinated subcutaneously with the capsular polysaccharde of type 7f s. pneumoniae to determine whether vaccination could prevent the development of experimental otitis media. following vaccination, 14 animals seroconverted wi ... | 1979 | 43345 |
| quantitative sputum gram stains in chronic bronchial disease. | | 1979 | 43418 |
| [bacteria isolated from cerebrospinal fluid specimens in gothenburg during a 5-year period]. | | 1979 | 43439 |
| superhelical dna in streptococcus sanguis: role in recombination in vivo. | competent streptococcus sanguis treated with non-lethal doses of coumermycin a1 immediately before or after uptake of radioactive transforming dna were reduced in their capacity to yield transformants. this treatment did not alter bacterial ability to bind dna in dnase i-resistant form, nor did it prevent the single-stranded donor dna-recipient protein complexes formed upon uptake at the surface of the bacteria from translocating to chromosomal sites. inhibition of transformation by heterospecif ... | 1979 | 43456 |
| the role of bacterial enzymes in inducing inflammation in the middle ear cavity. | current knowledge of the pathophysiology of bacterial infections is elementary. thie initial events leading to the invasion of host tissues are a matter of conjecture for many bacterial organisms. this is particularly true for pneumococci, the most frequent causative organisms of acute otitis media. bacterial enzymes may account for the initial disruption of host tissues, and this study explored their role in the infectious process. as first step, pneumococcal cultures were analyzed, and signifi ... | 1979 | 43503 |
| rosaramicin versus penicillin g in experimental pneumococcal meningitis. | rosaramicin, a new macrolide antibiotic, was compared with penicillin g in the treatment of pneumococcal meningitis in rabbits. animals were infected intracisternally with 10(4) colony-forming units of streptococcus pneumoniae type iii (rosaramicin minimal inhibitory/bactericidal concentrations, 0.25/0.5 mug/ml; penicillin g minimal inhibitory/bactericidal concentrations, 0.03/0.06 mug/ml). treatment was instituted 96 h later. infusion of rosaramicin at 25 mg/kg per h intravenously for 8 h produ ... | 1979 | 43705 |
| [antipneumococcal vaccine]. | | 1979 | 43818 |
| a rapid bile solubility test for pneumococci. | | 1979 | 43869 |
| morphology of the antibody response to pneumococcal polysaccharide in mice. | in the course of an antibody immune response to pneumococcal polysaccharide - type iii (s iii) in mice a slight increase was observed in the proportion of plasma cells among the antibody-producing cells, reaching its peak at the time of decline of this reaction. on the basis of ultrastructural resemblance of these plasma cells to primitive reticular cells and in view of other specificities of the immunological response to s iii antigen, the author presumes direct reticular origin of anti-s iii a ... | 1979 | 43878 |
| [the bacteriological findings between the middle ear and the pharynx in cases of acute suppurative otitis media (author's transl)]. | | 1979 | 43887 |
| unsuspected bacteremia in young children: a common and important problem. | | 1979 | 43959 |
| pneumococcal vaccination in recipients of renal allografts. | | 1979 | 44020 |
| splenic autotransplant function in experimental bacteremia. | | 1979 | 44021 |
| serotypes of streptococcus pneumoniae causing disease. | serotypes of streptococcus pneumoniae from 525 infected children were examined over a four-year period. type distribution was similar among 84 cases of bacteremia and 30 cases of meningitis, with types 6, 14, and 18 accounting for half of the illnesses. in contrast, half of 396 episodes of otitis media were caused by three other types, 19, 23, and 3. four of eight fatalities were due to type 6. carrier strains isolated from children had a distribution of types similar to that of the otitis media ... | 1979 | 44310 |
| the immune response to type ii and type viii pneumococcal vaccines in basilea rabbits lacking k light chains. immunochemical and partial amino acid sequence studies of the light chains. | | 1979 | 44345 |
| the structural correlates of the rabbit light chain b allotypes: sequence studies of b5 and b6 chains. | | 1979 | 44346 |
| does penicillin kill bacteria?. | the thesis is presented that the bactericidal action of penicillin and of other inhibitors of cell wall peptidoglycan synthesis, such as vancomycin and cycloserine, is secondary or tertiary to their ability inhibit specific reactions in the assembly of an osmotically protective cell wall. examples are given of the inhibition of these reactions, which results in inhibition of cell growth (bacteriostatic action) in the absence of either cellular lysis or rapid loss of viability. thus, in some inst ... | 1979 | 44383 |
| evaluation of phagocytic and bactericidal activities of neutrophil granulocytes. determination of viable extracellular bacteria by their incorporation of 14c-leucine and 3h-thymidine. | a method for evaluation of human neutrophil granulocyte function based on the combined determination of total and extracellular bacteria is described. the total number of surviving bacteria is assessed by the determination of colony forming units (cfu) after hypotonic lysis of granulocytes. extracellular viable bacteria can be determined by the incorporation of 14c-leucine or 3h-thymidine into bacterial macromolecules since there is a linear relationship between macromolecular synthesis and bact ... | 1979 | 44387 |
| [the pneumococal vaccine in children]. | | 1979 | 44476 |
| comparison of sputum counterimmunoelectrophoresis and culture in diagnosis of pneumococcal pneumonia. | the diagnostic value of counterimmunoelectrophoresis performed on sputum was compared with that of sputum culture. the detection of pneumococcal polysaccharide in sputum showed a better correlation with the presence of pneumococcal pneumonia than the recovery of pneumococci by culture. the authors conclude that sputum counterimmunoelectrophoresis can provide diagnostic guidance to physicians awaiting the results of sputum culture and aid in the interpretation of cultural findings. | 1979 | 44516 |
| [severe pneumococcal infections of adults. 100 cases collected in three years (claude bernard hospital, paris) (author's transl)]. | after retrospective in intensive care unit of 100 severe cases of pneumococcal infection in three years, the authors analyse the circumstances of onset (occurring in autumn of winter), the general status (without evident high risk population), the symptomatology (84% of meningitis, 30% of pneumonia), the origin of infection (essentialy otitis media in meningitis). the case fatality rate is 39%. frequency of multiple visceral localisations and of bacteremias is emphasized. | 1979 | 44735 |
| [pneumococcal infections in military quarters (author's transl)]. | a retrospective study on prevalence of pneumococcal in french military recruits of two military districts has been made in 1976 and 1977. among 185,000 adults, 19 pneumococcal diseases were registered (0,1%). 15 were respiratory infections (10 acute pneumonia). the agent has been isolated of blood (the half) and of others samples : expectoration... (the half). in despite of geographical and climatic differences of two districts, the incidence of pneumococcal pneumonia is the same. the low preval ... | 1979 | 44736 |
| [epidemiologic features of pneumococcal meningitis in africa. clinical and serotypical aspects (author's transl)]. | pneumococcal meningitis, because of their frequency and their severity, are regarded as an important problem of public health in africa. in a great number of african countries, particularly equatorial and central africa, the pneumococcus is the first agent of bacterial meningitis. the annual prevalence is estimated as about 14/100 000 persons. the case fatality rate (on 1 600 cases) is 49,5% ; the annual mortality reaches about 7/100 000 (28 000 annual deaths in africa). the babies and the old p ... | 1979 | 44737 |
| [contribution of counter-immunoelectrophoresis (electro-immunodiffusion) to the diagnosis of pneumococcal meningitis (author's transl)]. | the author has used the counter-immunoelectrophoresis (cie) comparatively with the routine bacteriologic method, in 220 pneumococcal meningitis at dakar hospital. the omni-serum of statens serum institute copenhague applied to csf, leads to detection of the quasi whole of antigens. the use of serums-pools is not essential in routine because his small supplement of information. the score of cie is the same that the results of bacteriologic method, but the cie is alone positive in 10,9% of cases. ... | 1979 | 44738 |
| [distribution of streptococcus pneumoniae serotypes in nantes hospital (1969-1978) (author's transl)]. | between 1969 and 1978 at the chr of nantes we isolated streptococcus pneumoniae from 815 swabs taken from 591 patients and which provided 595 different strains. serotyping of all the strains was carried out using the capsular reaction test. the prevalence of the different serovars varied according to the year and the type of swab. no resistant strains to benzylpenicillin or ampicillin were observed. there was significant resistance to sulphonamides and tetracycline : 24,3 and 29,6% respectively. ... | 1979 | 44739 |
| [pneumococcal capsular types of clinical specimens. lyon: 1972-1977 and 1978 (author's transl)]. | 878 strains of streptococcus pneumoniae were tested during two periods : 667 strains from 1972 to 1977 and 211 strains during 1978. strains were isolated from spinal fluids, blood, peritoneal fluids, urines, exudate from respiratory tract except sputum. in polymicrobial specimens, only the predominant species were serotyped. from 1972 to 1977, 53,3% of strains are typed and 6 serotypes and pools are prevalent among 68,5% of typed strains, the most frequent are : 6 - d - 18 - 19. during the secon ... | 1979 | 44740 |
| [pneumococcal serotyping. multicentric inventory in hospital. years 1977-1978 (author's transl)]. | for a period of 17 months, 670 pneumococci, mostly isolated in the paris area, have been typed with contercurrent-immunoelectrophoresis ; 338 of them come from cases of pneumonia, bacteremia, meningitis and acute otitis media. an important regrouping of the most frequent serotypes among the 83 known serotypes makes possible a vaccinal prophylaxis. the tetradecavalent vaccine which is now for sale in usa gives, in the four main pathologies of this enquiry, a coverage superior to 80 percent. choos ... | 1979 | 44741 |
| pneumococcal vaccines. | | 1979 | 44742 |
| comparative study of erythromycin, amoxicillin and ampicillin antimicrobial activity against human respiratory tract pathogens. | an in vitro test system was used to compare the antimicrobial activity of erythromycin, amoxicillin and ampicillin against respiratory tract pathogens isolated from man. the minimum inhibitory concentrations (mics) of fresh clinical isolates of streptoccus pyogenes, streptocuccus pneumoniae, staphylococcus aureus and haemophilus influenzae to the macrolide and penicillins ranged between 0.01 and 0.9 microgram/ml. the microbes were exposed to each antibiotic for approximately 3 h at 1x,2x and 5x ... | 1979 | 44765 |
| [animal experiments with combined local immunization against an influenza virus disease (author's transl)]. | | 1979 | 44774 |
| distribution of streptococcus pneumoniae types in norway. | a total of 129 isolates of streptococcus pneumoniae from nasopharyngeal specimens was typed by the neufeld reaction using diagnostic antipneumococcus sera produced at statens seruminstitutt, denmark. most isolates (87.6%) reacted with the serum pools b (41.9%), h (34.9%), and d (10.8%) comprising the types 3, 6, 8, 9, 11, 13, 14, 15, 16, 19, 23, 28, 36 and 37. only 12.4% of the isolates belonged to the remaining six serum pools. among the strains reacting with serum pools b, d, and h, the most f ... | 1979 | 44902 |
| evaluation of cefaclor and amoxycillin in the treatment of acute otitis media. | twenty-eight patients with acute otitis media were treated in a random double blind manner with either amoxycillin or cefaclor. the predominant organisms isolated were h. influenzae and s. pneumoniae. all patients responded satisfactorily except one, treated with cefaclor, whose compliance with the regimen was very doubtful. one instance of mild elevation of sgot and one case of mild erythematous rash occurred in each treatment group. in this limited study, cefaclor appeared comparable to amoxyc ... | 1979 | 44907 |
| treatment of acute bacterial bronchitis and pneumonia with cefaclor. | sixty patients with pneumonia and/or bronchitis were treated with cefaclor, a new orally administered cephalosporin. of those 60, 27 adults were treated with 500 mg every 8 hours, 26 adults with 250 mg every 6 hours, and 7 children with 50 mg/kg/day. in the adults, pneumonia was caused most frequently by streptococcus pneumoniae and haemophilus influenzae. the 7 children had pneumococcal pneumonia. all but 2 adults, both elderly patients with chronic obstructive pulmonary disease, were successfu ... | 1979 | 44908 |
| cefaclor: clinical and bacteriological evaluation in 45 cases. | this report deals with studies of the effectiveness, tolerance and toxicity of cefaclor in the treatment of 45 patients with urinary tract infections (40 cases) and pneumonia (5 cases) caused by susceptible pathogens. cefaclor was administered orally in a dosage of 1 to 3 g per day for 7 to 11 days. clinical and laboratory examinations were performed before, during, at the end of treatment, and 4 weeks later in cases of urinary infection. all 5 patients with pneumonia and bronchopneumonia were c ... | 1979 | 44909 |
| acceptance and efficacy of pneumococccal vaccine. | | 1979 | 45055 |
| [in vitro activity of cefaclor (author's transl)]. | a comparative study was conducted on the in vitro activity of cefaclor and other oral cephalosporins against a large number of freshly isolated clinical strains of gram-negative and gram-positive bacteria. the activity of cefaclor against gram-positive pathogens is very similar to that of cephalexin. the action of cefaclor against streptococcus pneumoniae is superior. cefaclor is the most active antibiotic against strains of haemophilus influenzae, and is also more active than cephalexin and cep ... | 1979 | 45087 |
| summary of laboratory studies on the antibacterial activity of cefaclor. | laboratory aspects of cefaclor, a new orally-effective cephalosporin antibiotic, are summarized. on the basis of data from a variety of studies, the useful antibacterial spectrum of cefaclor is shown to include all classes of bacteria that are generally susceptible to cephalothin and cephalexin. cefaclor has a significant potency advantage over cephalexin against many enterobacteriaceae, haemophilus sp. and streptococcus pneumoniae. bacteria that are susceptible to cefaclor are killed by concent ... | 1979 | 45088 |
| [reevaluation of the treatment of acute bacterial pneumonias (author's transl)]. | in spite of extreme and persistent susceptibility to antibiotics, specially benzylpenicillin, the pathology due to pneumococcus remains frequent and serious. from 14 cases of pneumococcal meningitis associated with pneumonia the authors have studied the relationship between these two localizations. they conclude that meningeal seeding appears most frequently secondarily and is probably latent at the beginning. moreover they note that treatment of pneumonia by itself does not always prevent the o ... | 1979 | 45277 |
| relation of colonial morphologies of strain of streptococcus pneumoniae in soft-agar to the encapsulation. | among 40 fresh isolates of streptococcus pneumoniae 12, 25 and 3 strains, respectively, exhibited large round, small round and compact colonial morphologies in soft-agar medium. every large round strain possessed a capsule, almost half of the small round strains had capsules, while all of the large round type growth showed very high mouse virulence and 1.0 mg of these organisms was capable of absorbing a minimal amount of passive protective antibody in rabbit antiserum, prepared with the homolog ... | 1979 | 45301 |
| [report of the 3d international conference on the immunology of meningococcal meningitis. current status of meningococcus b vaccine]. | | 1979 | 45419 |
| frequency and severity of pneumococcal infections. prevalence in the community population of the city of tourcoing. | | 1979 | 45428 |
| emergence of antibiotic resistance in hospitals, 1935-1975. | a limited review of the changes in susceptibility of common bacterial pathogens to available antibacterial agents is presented. significant developments in recent years include the following: (1) the emergence of streptococcus pneumoniae with decreased resistance to penicillin and of some strains resistant to several antibiotics; (2) a decline in prevalence of multi-drug-resistant staphylococcus aureus after 1960 following their increasing prevalence in the preceding years (these changes were me ... | 1979 | 45521 |
| genetic determinants of microbial resistance to antibiotics. | emergence of antibiotic resistance is related to the ease of mutation, to the extent of exchange of genetic information in bacteria by conjugation, transformation, and transduction, and to the large-scale use of antimicrobial agents in the biosphere. in addition to the development of resistance through chromosomal mutation and exchange of chromosomal genes among organisms, there is a more profound enlargement of the gene pool by the dissemination and amplification of plasmids. two examples of th ... | 1979 | 45522 |
| [microbiological characteristics of pneumonia in acute leukosis]. | | 1975 | 45963 |
| specific isolation and characterization of antibody directed to binding site antigenic determinants. | the preparation and specificity of antibodies specific for the ligand-binding site of hopc 8, a phosphorylcholine (pc)-binding mouse myeloma protein, are described. antiserum to hopc 8, prepared in rabbits, was adsorbed with an hopc 8-sepharose immunoadsorbent and anti-binding site antibodies were eluted with pc. these antibodies reacted with hopc 8 but not other myeloma proteins, including those with pc-binding specificity different from hopc 8; the specificity of this anti-hopc 8 antibody for ... | 1975 | 46246 |
| opsonin and leukophilic gamma-globulin in chronically splenectomised rats with and without heterotropic autotransplanted splenic tissue. | | 1975 | 46590 |
| fine structure and distribution of extracellular polymer surrounding selected aerobic bacteria. | the structure and distribution of extracellular polymer surrounding bacillus circulans, diplococcus (streptococcus) pneumoniae, streptococcus salivarius, staphylococcus aureus, klebsiella pneumoniae, pseudomonas aeruginosa, herella vaginacola (acinetobacter calcoaceticus), and agrobacterium tumefaciens were studied by electron microscopy. a modified ruthenium red staining procedure was used to examine the fine structure of capsule and slime. freeze-etching and critical-point drying were used to ... | 1975 | 46774 |
| letter: bacteraemia caused by tetracycline-resistant pneumococcus type 1. | | 1975 | 48665 |
| inhabition of murine plasmacytoma tepc 15 by its specific antigen. | | 1975 | 49023 |
| a radioisotopic method to measure delayed type hypersensitivity in the mouse. i. studies in sensitized and normal mice. | delayed type hypersensitivity (dth) lesions have been difficult to evaluate objectively in the mouse because they are usually assessed in terms of an increase in footpad swelling or ear thickness. we have developed a radioisotopic method which not only reduces the observer's error but also gives an objective measurement of the cellular activity in the lesions. in brief, 10 mul of the test antigen is injected intradermally into the left pinna and either nothing or the same volume of a control sol ... | 1975 | 51830 |
| inhibition of murine plasmocytoma tumours with antibody activity by their respective specific antigens. | three murine plasmocytoma tumour which secrete specific antibodies have been studied for the effect of specific antigens (pneumococcal c polysaccharide and dinitrophenylated bovine gamma globulin) on the growth of these tumours in vivo. in each case, the effect of the specific antigen was to inhibit the growth of that tumour which synthesized the specific antibody. low molecular weight haptens had no effect on tumour growth. we suggest that this antigen specific growth inhibitory effect is a fun ... | 1975 | 55094 |
| aglycosylantibody. effects of exoglycosidase treatments on autochthonous antibody survival time in the circulation. | rabbit anti-hapten antibodies were purified by affinity chromatography and characterized immunochemical for in vivo studies of their blood clearance rate and organ distribution after treatment with various glycosidases. following sequential removal of sialic acid, galactose, and n-acetylglucosamine with the appropriate cellulose-immobilized exoglycosidases, the antibody populations were recharacterized, radiolabeled, and introduced intravenously into the original animals. using double radioiodin ... | 1976 | 55413 |
| proceedings: antigen binding and idiotypic properties of reconstituted igg derived from homogeneous rabbit antipneumococcal antibodies. | | 1975 | 56328 |
| the occurrence of antibodies in rabbit anti-pneumococcus antisera directed against calcium dependent and independent determinants. | two type specific acidic pol-saccharides from pneumococci (type iii and type viii) have been used to prepare immuno-adsorbents. the polysaccharides were coupled to sepharose 4b via a 1,6 hexanediamine spacer and used to isolate two populations of type specific antibodies from rabbit anti-pneumococcus antisera. one population requires calcium to affect interaction with the homologous polysaccharide, while the other population has no such requirement. the isolated antibodies are of the lgg class a ... | 1975 | 57091 |
| [immunocytogenesis and formation of antibodies in experimentally aged animals (author's transl)]. | the authors use white rats with experimentally induced progeria-like syndrome of selye. the immunologic response following inoculation with the extracellular microbe-parasite d, pneumoniae and the intracellular parasite br. abortus 19 is studied serologically, cellularly and biochemically. the experimentally aged rats show diminished and retarded plasmocyte reaction and weaker and slower agglutinine synthesis as compared with the controls. the immunochemical analysis of the serums of the experim ... | 1976 | 60831 |
| the relationship between hypervariable regions, antigen-binding specificity and the three-dimensional structure of antibodies. | the amino acid sequences of the v domains (vl + vh regions) of 3 antibodies raised to type iii pneumococcal polysaccharide in individual outbred rabbits are reported. with the exception of the second hypervariable section of the l chains, these antibodies have very different sequences in the hypervariable segments of the v domains. within the third hypervariable region of the h chain, each antibody has a different length. on the sole basis of the amino acid sequences of these three anti-pneumoco ... | 1976 | 60900 |
| diagnosis of pyogenic meningitis. | | 1976 | 61418 |
| antigen detection in chest infections. | | 1976 | 62121 |
| characterization of antigen-specific immunologic paralysis induced by a single low dose of polyvinylpyrrolidone. | | 1976 | 62838 |
| [rapid method of determination of pneumococcus sensitivity to antibiotics]. | | 1976 | 66391 |
| counterimmunoelectrophoresis in the diagnosis of bacterial meningitis. | the aim of the present study was to investigate whether counterimmunoelectrophoresis (cie) would facilitate the rapid, etiological diagnosis of bacterial meningitis when used in parallel with other routine methods in a medical bacteriological laboratory. of 3,674 consecutive specimens of cerebrospinal fluid (csf) received at the department of diagnostic bacteriology, statens seruminstitu, 283 specimens (each representing one patient) were selected for examination by cie on the basis of the follo ... | 1977 | 67124 |
| suppression of igm responses to type iii pneumococcal polysaccharide by lipopolysaccharide (lps). | | 1977 | 67907 |
| immunosuppression in murine malaria. i. response to type iii pneumococcal polysaccharide. | acute plasmodium yoelii yoelii and chronic plasmodium berghei malaria infections of cba mice were accompanied by a reduced capacity to give an antibody response to type iii pneumococcal polysaccharide (siii). the depression of response initiated by acute malaria persisted for several weeks after recovery from clinical infection. during chronic infection, and at the peak of acute parasitaemia, virtually no response to siii was detected. a substance which crossreacted serologically with siii was f ... | 1977 | 67996 |
| immunologic studies in pneumococcal disease. | many patients die from pneumococcal disease despite the availability of effective antimicrobial agents. immunologic studies including detection, typing, and quantitation of serum pneumococcal capsular polysaccharide (pcp) antigen by counterimmunoelectrophoresis (cie), quantitation of pcp antibody by radioimmunoassay (ria), and quantitation of serum complement components c3, c4, and c3pa and serum immunoglobulins igg, igm, and iga by the radial immunodiffusion technique of mancini were performed ... | 1977 | 68089 |
| immunisation with a polyvalent pneumococcal vaccine. reduction of adult respiratory mortality in a new guinea highlands community. | a double-blind controlled trial of a 14-valent pneumococcal polysaccharide vaccine was carried out in 11 958 adults at tari in the papua new guinea highlands. pneumococcal infection, confirmed by blood-culture and lung aspirate, was less in the vaccinated group by 84%. mortality from pneumonia was less by 44%. | 1977 | 69058 |
| resistant pneumococci. | | 1977 | 71606 |
| thomsen-friedenreich antigen in haemolytic-uraemic syndrome. | | 1977 | 72915 |
| streptococcus pneumoniae resistant to penicillin and chloramphenicol. | three cases of meningitis and two of septicaemia were caused by pneumococci resistant to the penicillins/cephalosporins and chloramphenicol. no beta-lactamase was demonstrated in any of the organisms. all three patients with meningitis died, but the patients with septicaemia recovered after being given appropriate antibiotic therapy. | 1977 | 72950 |
| immunological characterization of hela cell subpopulations enriched for blood group h or its precursor. | | 1977 | 73188 |
| specific and cross-reactive activation of rabbit peripheral blood lymphocytes by streptococcal vaccines. | the ability of primed rabbit blood lymphocytes to respond in vitro to the homologous streptococcal group antigen depends on its presence in culture in the form of vaccine or cell walls thereof. these lymphocytes can also be stimulated in vitro by streptococcal vaccines with chemically related group antigens. the basis for this cross-stimulation apparently resides in shared rhamnose moieties. activation of these lymphocytes was not achieved by vaccines from unrelated bacteria. there is also the s ... | 1978 | 74347 |
| immune response after splenectomy. | the immune response to intravenously administered bacteriophage phix 174 and subcutaneously administered tridecavalent pneumococcal polysaccharide vaccine was studied in 31 patients with anatomical or functional asplenia. antibody responses to primary immunisation with phix 174 were significantly decreased while clearance was normal. secondary responses were quantitatively normal; however, production of antibody did not switch from igm to igg as seen in controls. all groups of asplenic patients ... | 1978 | 74605 |
| differential expression of an equivalent clonotype among balb/c and c57bl/6 mice. | the primary anti-phosphorylcholine (pc) response in balb/c, c57bl/6, and congenic and recombinant inbred strains of these parental types has been examined in the splenic focus system. the frequencies of pc-specific precursors were shown to vary among these strains from 2 to 20 precursors per 10(6) splenic b cells. the distribution of these frequencies suggests that elements closely linked to or within the major histocompatibility complex may play a role in the determination of this parameter, al ... | 1978 | 75230 |
| further studies on endo-beta-n-acetylglucosaminidase d1. | the purification procedure for endo-beta-n-acetylglucosaminidase d was improved to yield an enzyme preparation which was homogeneous upon gel electrophoresis. the molecular weight of the enzyme as estimated by sephadex g-200 column chromatography was 280,000, while sds-gel electrophoresis after reduction with 2-mercaptoethanol gave a value of 150,000. the purified enzyme did not show any chitinase, hyaluronidase or lysozyme activity. in the presence of exoglycosidases removing peripheral sugars, ... | 1978 | 75885 |
| accuracy of gram's stain in identifying pneumococci in sputum. | we prospectively examined the accuracy of gram-stained sputum for identifying pneumococci in 42 patients with community-acquired pneumonia. we considered the gram's stain positive if a preponderant flora or more than ten gram-positive lancet-shaped diplococci were seen per oil immersion (x1,000) field. these criteria were met in 18 (62%) of 29 specimens that actually contained pneumococci as determined by a positive quellung reaction, or culture on plates or in mice. the gram's stain was negativ ... | 1978 | 77336 |
| chloramphenicol-resistant pneumococci in west africa. | | 1978 | 77402 |
| protection against fulminant sepsis in splenectomized mice by implantation of autochthonous splenic tissue. | infection of splenectomized mice with diplococcus pneumoniae, type iii, resulted in a fourfold higher mortality rate than did infection of normal mice. splenectomized animals were protected against fulminant, fatal sepsis by subcutaneous transplantation of autochthonous splenic tissue at the time of splenectomy. animals with ectopic splenic tissue, and sham-splenectomized control mice, exhibited normal serum opsonin and leukophilic gamma-globulin activity, with respect to pneumococcus, that was ... | 1978 | 77790 |
| antibiotic antagonism and synergy. | | 1978 | 78302 |