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[studies on the effectiveness of cephalosporins against neisseria gonorrhoeae]. 1979118493
the prevalence of group b streptococci in human urogenital secretions.urogenital secretions from a total of 510 patients (153 female and 151 male venereological patients, 123 gynaecological patients and 83 gynaecologically normal women) have been examined for group b streptococci (b-str.) and gonococci. the prevalence of b-str. (32%) among the female venereological patients was significantly higher than among the gynaecological patients (21.1%) and normal women (18.0%). urethral samples gave a higher recovery rate of b-str. than cervical samples. a significant cor ...1979118523
[effect of nitroimidazole therapy on the demonstration of gonococci].the minimal inhibitory concentration of metronidazole and tinidazole lies between 4000 micrograms/ml and 7.8 micrograms/ml. drug levels are present in this range for 2--5 hours in genital discharge following single dose oral therapy with 2 g tinidazole or 1.5 g metronidazole. therefore, 5-nitroimidazole derivatives exert a bacteriostatic effect in the genital region at least on the more sensitive strains. as shown in our experiments, otherwise reliable laboratory procedures for the demonstration ...1979118597
reverse passive haemagglutination test for the rapid identification of neisseria gonorrhoeae and detection of penicillinase production.in a comparison of the reverse passive haemagglutination test (rpha) with the direct immunofluorescent and rapid carbohydrate utilisation tests for the identification of neisseria gonorrhoeae isolated from clinical specimens, 315 isolates of oxidase-positive gram-negative diplococci were tested as pure 24-hour-old subcultures and samples from 108 similar organisms were taken directly from primary isolation plates. a similar test system was used to detect penicillinase production. results showed ...1979118798
evaluation of bactericidal assay in serotyping neisseria meningitidis group a.seventeen of 22 group a meningococcal strains were separated into four serotypes by a microbactericidal assay using group a antisera. in addition, 6 of 19 of these strains were killed by a group b antiserum and similar cidal patterns were obtained with a group c antiserum. there was little correlation between type and case or carrier isolates, or between types and geographical location.1979118800
experimental infection of the genital tract of female grivet monkeys by mycoplasma hominis: effects of different routes of infection.in a previous study we produced acute salpingitis and parametritis in grivet monkeys by inoculation of mycoplasma hominis directly into the uterine tubes. with the purpose of examining in the same animal model the effect of more natural routes of infection, six female grivet monkeys were inoculated, two by two, with m. hominis by the following methods: (experiment a) into the uterine cavity through the cervical canal; (experiment b) into the uterine cavity by the same route, but after ligature o ...1979118928
serological grouping of meningococci and encapsulated haemophilus influenzae strains by latex agglutination.the latex agglutination method, utilizing antibody-coated latex particles, was adapted for serogrouping of neisseria meningitidis and serotyping of encapsulated haemophilus influenzae strains from agar plates. it was found to give more clear-cut results than conventional slide agglutination. a 100% agreement with the antiserum agar method was found for all strains isolated from blood or cerebrospinal fluid. many meningococcal strains from nasopharyngeal carriers are autoagglutinable, but some of ...1979118981
kinetics of antibody production to group a and group c meningococcal polysaccharide vaccines administered during the first six years of life: prospects for routine immunization of infants and children.a cohort of infants, previously immunized once or twice between three and 12 months of age with vaccines containing polysaccharide of groups a and c neisseria meningitidis, received boosters at two and five and one-half years of age with bivalent a/c vaccine. antibody concentrations were measured by a radioactive antigen-binding assay. concentrations of antibody to groups a and c n. meningitidis were 5.59 and 2.86 microgram/ml, respectively, by four years of age. after booster immunization at fi ...1979118997
the role of natural igg and complement in the phagocytosis of type 4 neisseria gonorrhoeae by human polymorphonuclear leukocytes.the role of human serum components in the phagocytosis of logarithmic-phase type 4 neisseria gonorrhoeae by human polymorphononuclear leukocytes was investigated. the requirement of fresh normal human serum (fhs) for optimal phagocytosis and the fixation of human immunoglobulin (igg) and complenet (c3) to the gonococcal cell surface suggested that both serum factors participate in the phagocytosis of these organisms. the percentage of neutrophils containing ingested organisms was directly propor ...1979118998
the management of penicillin resistant gonococcal urethritis in northern nigeria.forty-five men, with acute gonococcal urethritis, were treated with a single dose regime of probenecid 1 gm and procaine penicillin, 4.8 mega-units, yielding a cure in 97 per cent. multiple antibiotic resistance was noted in 69 per cent of 28 neisseria gonorrhoeae isolates, and of 19 isolates tested for precise penicillin sensitivity, 58 per cent were resistant to greater than 2 i.u./ml. serum penicillin levels measured in 3 patients showed adequate duration of plateau levels. the advantages of ...1979119057
[meningococcus profilaxis (author's transl)].in a general hospital in san sebastian, 96 cases of neisseria meningitidis infections were detected in a two years period. by the use of the disk diffusion method, we found that all causative meningococcal strains but 4 were resistant to sulfonamide (with a 300 microgram sulfadiazine disk, all isolates with a zone diameter of less than 20 mm were considered to be resistant of sulfadiazine, whereas those with zone diameters of greater than 30 mm were considered susceptible). no rifampin nor minoc ...1979119117
cefoxitin in the treatment of gonorrhea.cefoxitin is active in vitro against beta-lactamase-producing strains of neisseria gonorrhoeae; therefore, its efficacy in the treatment of uncomplicated genital gonorrhea was evaluated in a study of ten men and 15 women. cefoxitin was administered in two intramuscular doses given 5 hr apart, patients alternately receiving either 1 g or 2 g of cefoxitin in each injection. probenecid (1 g) was administered orally with both injections to five women, and with the first injection only in the remaini ...1979119328
association between the auxogroup of neisseria gonorrhoeae and the minimal inhibitory concentration of penicillin.the auxogroups and the minimal inhibitory concentrations (mics) of penicillin for 885 recently isolated strains of neisseria gonorrhoeae were determined. auxogroups were established according to the growth requirements of the strains for proline (pro-), uracil (ura-), hypoxanthine (hyx-), citrulline (cit-), or citrulline replaceable by ornithine (orn-). the seven most common auxogroups studied were: pro-cit-ura- (38.8%), orn-hyx-ura- (24.1%), nonrequiring (nr) strains (13.4%), pro- (9.7%), orn- ...1979119329
colonization of the pharynx with neisseria gonorrhoeae: experience in a clinic for sexually transmitted diseases.at a clinic for treatment of sexually transmitted diseases, 1,453 patients were examined for pharyngeal colonization with neisseria gonorrhoeae. a history of oral sex was reported by 895 (61.2%) of the patients. n. gonorrhoeae was isolated from the pharynges of 42 (2.9%) of the 1,453 patients. twenty-seven of the 42 patients with n. gonorrhoeae-positive cultures gave histories of oral sex, and all 42 patients reported orogenital contact when questioned again at a follow-up visit. seven patients ...1979119330
[clinical laboratory study of gonorrhea in women]. 1979119364
acute epididymitis: etiology and therapy.fifty patients with acute epididymitis were evaluated prospectively by history, examination, and microbiologic studies, including cultures for aerobes, anaerobes, n. gonorrhoeae, chlamydia trachomatis, and ureaplasma urealyticum. e. coli was the predominant pathogen isolated from the urine of men over 35 years old and c. trachomatis and n. gonnorrheae were the predominant pathogens isolated from the urethra of men under 35. the etiologic role of e. coli and c. trachomatis was confirmed by isolat ...1979119499
male reproductive tract sequelae of gonococcal and nongonococcal urethritis.gonorrhea is the most frequent bacterial infection as well as the most frequently reported venereal disease. nongonococcal urethritis has approximately the same incidence as acute gonorrhea in cases reported by many venereal disease clinics. the relative epidemiology of the two diseases, as well as their acute and chronic manifestations in the male genital tract (urethritis, prostatitis, and epididymitis), will be briefly discussed. resultant obstructions of the lower genitourinary tract of poss ...1979119500
culture methods for neisseria gonorrhoea.cultures on an appropriate medium are both highly sensitive and specific, but false-negative cultures can occur because of sampling procedures, laboratory errors, sensitivity of certain gonococci to the vancomycin contained in selective mediums, or loss of bacterial viability in transport.1979119501
culture diagnosis of meningococcal carriers: yield from different sites and influence of storage in transport medium.different specimens and techniques have been used in the diagnosis of carriers of neisseria meningitidis, reflecting the uncertainty about the optimal diagnostic procedure. in the present investigation the culture yield of meningococci from throat specimens was compared to that from nasopharyngeal speimens in 178 persons: 44 carriers were diagnosed. all of them were detected by culture of throat specimens while 34% of them would have remained undiagnosed if only nasopharyngeal specimens had been ...1979119792
comparison of two selective media in the cultural diagnosis of gonorrhoea.a "chocolate" agar medium (ca-ncv) containing nystatin, colistin and vancomycin, was compared with the mnyc medium which contain lincomycin, colistin, amphotericin and trimethoprim. a total of 277 clinical specimens were cultured for gonococci, and 120 of these showed positive cultures on either or both of the media. the mnyc medium detected 96.6 per cent of the total number of positive cultures and 92.5 per cent of the patients and the ca-ncv medium after 80 and 79 per cent, respectively. nearl ...1979120106
variations in surface protein composition associated with virulence properties in opacity types of neisseria gonorrhoeae.the biological properties of a series of opacity variants of neisseria gonorrhoeae p9 have been examined. a novel protein, designated protein iid* (mol. wt 28 850), was identified within the set of heat-modifiable surface proteins previously reported. all variants producing extra outer membrane proteins were less sensitive to the bactericidal action of serum than the prototype transparent strain, with protein iia* (mol. wt 28 500) being associated with increased resistance. the production of a d ...1979120407
biological activity of an antibiotic produced by myxococcus coralloides.a strain of myxococcus coralloides was isolated which produced an antibiotic active against gram-positive bacteria and also against neisseria sp at high levels of antibiotic. the antibiotic was bactericidal on sensitive growing bacteria. it was inactive on non-growing cells and also on cells whose growth has been stopped by addition of chloramphenicol. strains of s. aureus resistant to several antibiotics, including penicillin and ampicillin, were also sensitive to this antibiotic.1979120482
variations in attachment of neisseria gonorrhoeae to vaginal epithelial cells during the menstrual cycle and early pregnancy.an in vitro system was used to study the ability of virulent gonococci to adhere to vaginal epithelial cells obtained from healthy donors during the pre- and postmenstrual phases, and from those in early pregnancy. it was found that more gonococci adhered to the cells from donors in the postmenstrual phase than to cells from those in the premenstrual one. this difference was statistically highly significant. the attachment rate of gonococci to vaginal epithelial cells was similar in early pregna ...1979120931
[campaign against meningococcal meningitis. national vaccination program]. 1977120953
[immunohistological findings in gonorrheic cervicitis (author's transl)]. 1979121080
an assay of the potential for transmission of disease by dental aerosols. 1979121287
[vaccine prophylaxis and chemoprophylaxis of cerebrospinal meningitis].the author points up a review on the argument accordingly to the most recent literatur. particularly are treated the status of meningococcal vaccines anti-a, c and y groups (their preparations and trends in field-trials), and the status of proteic vaccines anti-b. in the second part the most important substances in chemio-antibiotic prophylaxis are considered (rifampin, minocyclin, sulphadiazine, tmp, etc.) accordingly to their efficacy, safety and side-effects. the status of the perspectives on ...1979121683
meningococcal vaccines: results of prospective double blind trials usage in population at risk on gold fields mines. 1978121773
[clinical aspects and diagnosis of benign gonococcal septicemia]. 1979121785
isolation of beta-lactamase-producing neisseria gonorrhoeae. 1979121821
[in vitro immunologic changes in 4 patients with lepromatous leprosy and 4 patients with borderline leprosy treated with neisseria perflava for 17 to 25 months]. 1979121847
[researches on the production of inhibitory substances by strains of "n. meningitidis" (author's transl)].the possibility to produce some inhibitory substances has been researched in 85 strains of n. meningitidis belonging to different serogroups. by the double layer agar method, 9 of these strains have inhibited the growth of one or more indicator strains. we had the best results at 37 degrees c and 30 degrees c in tests made incubating 3 producer strains in different experiment conditions; the "brain heart infusion agar" and the "heart infusion agar" were the best and fittest culture media, used f ...1979122053
[the importance of chemoantibiotic resistance in controlling infections disease (author's transl)].the aa. examine those mechanisms which might determine the phenomenon of drug resistance in microorganism. they then review those infections of interest to public health. diseases such as meningococcus, enterobacterial and vibro infections frequently show chemoantibiotic resistance. the aa. procede to point out the problems which may arise during therapy or prophylaxis. some measures are then reported as necessary in order to prevent or retard the development of drug resistance in microorganism ...1979122153
screening by culture for the detection of gonorrhoea in women.the number of gonoccal infections detected by each of three sets of diagnostic cultures from the urethra, cervix, rectum and occasionally the throat, were calculated for 1976 when thayer martin (tm) medium was used and for 1977 when modified new york city (mnyc) medium was used. in 1977, 98.7 per cent (451/457) of the total infections diagnosed were confirmed by culture compared with 88.3 per cent (324/367) of infections diagnosed in 1976 (p less than 0.001). the first set of diagnostic tests de ...1979122170
[detection and diagnosis of gonorrhea in women]. 1979122275
[different serogroups of neisseria meningitidis in sick people and in the normal population]. 1979122281
[application of the reverse passive haemagglutination test for the detection of group a, b and c meningococcal antigens (author's transl)]. 1979122300
in vitro activity of piperacillin, a new semisynthetic penicillin with an unusually broad spectrum of activity.the in vitro activity of piperacillin (t-1220), a new semisynthetic derivative of aminobenzylpenicillin, was investigated. the majority of streptococci and pneumococci were inhibited by 0.12 micrograms/ml; the staphylococci and enterococci were inhibited by 2 micrograms/ml. piperacillin was slightly more active against neisseria and haemophilus influenzae than was ampicillin. piperacillin was active against all members of the enterobacteriaceae including the klebsiella, 58% of which were inhibit ...1978122518
in vitro study of clavulanic acid in combination with penicillin, amoxycillin, and carbenicillin.the activity of clavulanic acid alone and in combination with penicillin, amoxycillin, and carbenicillin was studied. marked reductions in the minimum inhibitory concentrations (mics) for a wide spectrum of beta-lactamase-producing clinical isolates were found. of particular interest were the decreased mics of penicillin for bacteroides fragilis and beta-lactamase-producing strains of neisseria gonorrhoea in the presence of the clavulanic acid. beta-lactamase-producing strains of escherichia col ...1978122520
effect of benzylpenicillin on the synthesis and structure of the cell envelope of neisseria gonorrhoeae.the effect of benzylpenicillin on the synthesis and morphology of the cell envelope of neisseria gonorrhoeae was examined. penicillin immediately stopped murein synthesis; it also enhanced the rate of turnover of glucosamine, but not diaminopimelic acid, in the murein. in addition, penicillin greatly increased the shedding of lipid and lipopolysaccharide into the medium. in the electron microscope, protrusions of the cell membrane were evident, as well as apparent holes in the murein cell wall. ...1978122527
sectinomycin in the treatment of gonorrhoea in females and males.126 female patients with proven gonococcal infection were treated with 4 g. spectinomycin bihydrochloride given intramuscularly in a single does. in 120 cases followed up there were four possible treatment failures, giving a cure rate of 97-6 per cent. 99 male patients with acute gonococcal urethritis were treated with a single dose of 2, g. sectinomycin bihydrochloride. of 88 cases followed up, there were three possible treatment failures, giving a cure rate of 96-6 per cent. spectinomycin is a ...1975123818
[study on gonorrhea. summaries of publications i-v]. 1975124631
sensitivity of haemophilus vaginalis (corynebacterium vaginale) to oleandomycin and spectinomycin.haemophilus vaginalis is highly sensitive to oleandomycin. the mic ranged from 0.035 to 0.15 mug/ml. the sensitivity of h. vaginalis to spectinomycin was 2.5-5.0 mug/ml. the sensitivity of h. vaginalis to spectinomycin is 3-4 times higher than that of neisseria gonorrhoeae. a favourable effect in the treatment of vaginitis caused by h. vaginalis could thus be expected.1975125402
[spectinomycin. indications and undesirable effects].modern chemotherapy postulates highly active drugs without unwanted side effects. in the treatment of gonorrhea spectinomycin meets even the strictest requirements: maximal obtainable cure rates, no masking of concomitant syphilitic infections, and excellent tolerance. in animal experiments no sensitizing effect of spectinomycin was found even when maximation procedures were applied. anaphylactoid activity of spectinomycin is low, as has been documented by personal investigational series.1975125921
adjuvant activity of bacterial peptidoglycans.purified peptidoglycans isolated from various gram negative and gram positive bacteria can substitute for mycobacteria in freund's adjuvant. monomeric subunits possess the same adjuvant activity. this activity seems to be related to the peptidic fraction.1975126567
[letter: gonorrhea treatment by the family physician]. 1975127128
national gonorrhea therapy monitoring study: in vitro antibiotic susceptibility and its correlation with treatment results.to monitor temporal trends and regional differences in antibiotic susceptibility, we measured the minimum inhibitory concentrations for penicillin g, ampicillin, tetracycline, and spectinomycin of 4405 pre-treatment gonococcal isolates from patients with uncomplicated gonorrhea. as compared to isolates studied in 1970-1971, recent united states isolates appeared equally sensitive to penicillin g and more sensitive to tetracycline. relatively resistant strains were found throughout the country. w ...1976127947
[differential traits and antigenic properties of the s- and r-forms of neisseria meningitidis].the authors demonstrated a marked dissociation of the neisseria meningitis cultures and the capacity to their rapid change from s- to r-forms. differential signs of the s- and r-forms are described. differences in the degree of dissociation of the cultures depending on their origin were shown: strains isolated from the cerebrospinal fluid and the blood of patients with meningitis proved to be less dissociated, and those isolated from carriers--more dissociated. transfers from media to media and ...1975128964
group b streptococci in venereal disease clinic patients.the isolation rates of group b streptococci for 457 men and 300 women attending a venereal disease clinic were 16-4 and 20-6% respectively. the frequencies were significantly increased by using a selective medium and by taking specimens from the female urethra as well as the cervix. in contrast to gonorrhoea the presence of group b streptococci could not be related to promiscuity. in addition, the isolation of group b streptococci was found to be independent of a concomitant gonococcal infection ...1975130184
drugs five years later. spectinomycin.a single intramuscular injection of 0.2 g of spectinomycin hydrochloride is highly effective for the treatment of uncomplicated anogenital infections with neisseria gonorrhoeae. spectinomycin hydrochloride is indicated for uncomplicated anogenital gonococcal infections in men and women who cannot receive penicillin or probenecid, and is the drug of choice for the retreatment of patients with uncomplicated anogenital gonococcal infection who have not responded to other antibiotics. a single dose ...1976132888
diagnosis and treatment of pelvic inflammatory disease and gonorrhea in the emergency department.one hundred emergency department charts on cases of suspected pelvic inflammatory disease (pid) were reviewed to determine method of diagnosis and treatment. seventy-three gonococcus smears, 60 gonococcus cultures, and 53 vdrl tests for syphilis were done. of these, 20 smears, 19 cultures, and 1 vdrl were positive. all 100 patients were treated for gonorrhea with either spectinomycin, tetracycline, ampicillin or penicillin. the author concludes there is no need to procure vdrl tests on all patie ...1976138761
[various clinico-laboratory data during treatment of gonorrhea with penicillin and coamide]. 1976139045
spectinomycin versus tetracycline for the treatment of gonorrhea.spectinomycin and tetracycline are alternative drugs to penicillin in the treatment of gonorrhea. to compare the efficacy of these agents and their propensity to select resistant gonococci, we treated 4043 patients randomly with either 2 or 4 g of spectinomycin once or 9 g of oral tetracycline for four days. minimum cure rate for anogenital gonorrhea was 94 per cent with either drug. oropharyngeal infection responded poorly to spectinomycin in men, with failure of therapy in six of 11. postgonoc ...1977139565
treatment of gonorrhea -- is penicillin passé. 1977139566
treatment of uncomplicated gonorrhoea with spectinomycin hydrochloride (trobicin).110 patients with uncomplicated gonococcal urethritis were treated with 2 g spectinomycin (trobicin) intramuscularly. seventy-five patients were available for follow-up and there was only one treatment failure, giving a cure rate of 98-6%. of the 99 gonococcal isolates, 59 were sensitive to 5 microng/ml of spectinomycin or less and 40 were sensitive to 10 microng/ml. in a small sample of patients 2 g spectinomycin intramuscularly produced a serum concentration averaging 100 microng/ml after one ...1977139968
penicillinase-producing strains of neisseria gonorrhoeae isolated in rotterdam.this appears to be the first report of the isolation of a penicillinase-producing strain of neisseria gonorrhoeae in the netherlands. the presence of a penicillinase-producing gonococcal strain (ppgs) was demonstrated in two of a group of three patients with gonorrhoea. in addition, a penicillin- and ampicillin-sensitive gonococcus strain was isolated from all three patients. the ppgs was most probably imported into holland from the philippines. the epidemiological and clinical findings and the ...1977139969
[detection of neisseria meningitidis in pharyngeal exudates using a new culture media: agar n.m.8]. 1977141294
the sensitivity of gonococci to penicillin. 1977141439
[bacteriological findings in chronic infantile tonsillitis (author's transl)].under general anaesthesia cultures were taken from infantile tonsils prior to t & a. the bacteriological results and the serological classification of hemophilus are questionning literature reports. according to our findings one must consider haemophilus influencae as a resident of the common oral flora. there was no significant difference culturing tonsils with or without repeated antibiotic treatment. hemophilus influencae combined with beta-hemolytic streptococci is common. immunological cons ...1977141563
penicillin-resistant gonococci: result of plasmid promiscuity. 1977141731
in vitro susceptibility of tucson isolates of neisseria gonorrhoeae to penicillin, tetracycline, and spectinomycin. 1977142463
disseminated gonococcal infections caused by neisseria gonorrhoeae with unique nutritional requirements.disseminated gonococcal infection occurs in 1%-3% of patients with gonorrhea in seattle. most strains of neisseria gonorrhoeae recovered from patients with disseminated gonococcal infection are susceptible to less than or equal to 0.015 mug of penicillin g/ml. strains susceptible to less than or equal to 0.015 mug/ml, whether isolated from patients with disseminated gonococcal infection or from those with uncomplicated infection, did not grow on chemically defined medium prepared with several lo ...1975125773
trends and seasonality of antibiotic resistance of neisseria gonorrhoeae.over 8,400 pretreatment isolates of neisseria gonorrhoeae collected in the united states between november 1972 and april 1975 were tested for their in vitro resistance to penicillin, ampicillin, tetracycline, and spectinomycin. trends and seasonality of resistance were examined by use of a harmonic regression technique. during the study period, there was a significant difference among years in the mean minimal inhibitory concentrations (mics) for each antibiotic (p less than 0.001 for penicillin ...1977144170
activity of eight antimicrobial agents in vitro against n. gonorrhoeae.the sensitivity of four groups of gonococcal strains to ampicillin (am), penicillin (p), tetracycline (t), rifampicin (ri), spectinomycin (sp), sulphamethoxazole (su), trimethoprim (tr), and a combination of su and tr in the ratio 5:1 (su/tr 5:1) has been determined. the various groups of strains were isolated from male civilians (mc), female civilians (fc), and sailors (s) in rotterdam (r) in 1972, and from fc in amsterdam (a) in 1967. the s-r strains, which may be regarded as mainly imported, ...1975125618
[survey of the sensitivity of the strains neisseria gonorrhoeae to antibioticas in the cssr during 1957-1973 (authors transl)].although the preponderant majority of gonococcal strains is belonging to the most susceptible micro-organisms in respect of the action of antibiotics, certain variations of sensitivity which might be of importance not only for the genetics of microbes, but also for biochemistry and, above all, for therapy may occur also among them, perhaps as a consequence of along-time pressure by antibiotics. in a preceding study (j. hyg. epidem. microb. immunol. (prague) 12,296, 1968), the authors analyzed th ...1975125512
gonococcal proctitis in a married woman. report of a case. 1977144805
deoxyribonucleic acid repair capacities of neisseria gonorrhoeae: absence of photoreactivation.no difference in survival was observed when ultraviolet-irradiated gonococcal cells were subsequently incubated in the dark or exposed to photoreactivating light. this observation indicates that photoreactivation is absent in neisseria gonorrhoeae.1979118154
a comparative study of adverse factors in meningococcaemia and meningococcal meningitis. 1979118439
cellular immunity in patients with meningococcal disease and in vaccinated subjects.cell-mediated immunity was studied in patients with group a meningococcal meningitis and in normal subjects given group a meningococcal vaccine. lymphocytes responsiveness to phytohaemagglutinin and to meningococcal antigens was markedly depressed in patients with acute meningococcal infection. this defect was present when lymphocytes were cultured in autologous or foetal calf serum. patients also showed a transient increase in the degree of inhibition produced by whole group a meningococci in l ...1979118835
[application of the indirect hemagglutination test for the determination of titres of meningococcal antibodies (author's transl)]. 1979120476
[chlamydia trachomatis and neisseria gonorrhoeae in acute salpingitis]. 1979120804
cefaclor in the treatment of uncomplicated gonococcal urethritis.cefaclor is a cephalosporin antibiotic whose chemical structure is similar to that of cephalexin. the substitution of a chloro group for the methyl group of cephalexin has produced a compound with markedly improved antibacterial activity, while retaining the property of gastrointestinal absorption. cefaclor has shown good in vitro activity against neisseria gonorrhoeae. in a controlled clinical trial, 40 men with uncomplicated gonococcal urethritis received cefaclor given as a one gram loading d ...1979121455
gonococcal anogenital infection. 1975123489
antibiotic susceptibility of neisseria gonorrhoeae isolated in the western pacific in 1971.isolates of neisseria gonorrhoeae from 256 patients contracting acute gonococcal urethritis, primarily in the republic of the phillipine islands, in 1971, were tested for the minimum inhibitory concentrations of five antibodies. the median is advocated as a measurement for comparison of ranges of mic values; the median mic of penicillin for 258 isolates was 0-23 mug/ml. a positive correlation coefficient was observed for the susceptibility of isolates to penicillin, spectinomycin, cephaloridine, ...1975123817
the treatment of acute gonococcal urethritis in the canadian forces with spectinomycin hydrochloride. 1975124202
[microbiological diagnosis of meningococcal infections]. 1975128805
resistance of neisseria gonorrhoeae to antibacterial drugs in ontario.observations on multiple resistance of 227 n. gonorrhoeae strains are presented in this paper. these strains were previously isolated from the urogenital area from patients who did not respond to antibacterial drug treatment. the above-mentioned strains were referred to our laboratory for confirmation and for susceptibility testing. all the n. gonorrhoeae strains showed resistance in vitro to penicillin concentrations between 0.5-2.0 i.u./mi. in addittion to penicillin resistance, 83.7% showed r ...1976131116
increased antibiotic resistance of neisseria gonorrhoeae in korea.there has been a marked increase in the resistance of neisseria gonorrhoeae isolated in korea to penicillin, ampicillin, and tetracycline. in contrast, there has been no increased resistance to spectinomycin.1976131510
asymptomatic urethral gonorrhea among men in public new york city social hygiene clinics.cultures were made from the urethra of 2,370 male social hygiene clinic patients who were not directly associated with gonorrhea by signs, symptoms or epidemiology were cultured for n. gonorrhoeae. of these asymptomatic individuals, 37 or 1.6% were found to be urethrally infected. gram stain smear examinations of urethral specimens from these men were positive in about one-half of the cases.1976134011
[serologic pattern of meningococci in a focus of infection].the authors present the results of typing of meningococci (isolated from the patients and carriers) by the sera of serological groups a, b, c, d, x, y, and z made at the leningrad institute of vaccine and sera. the causative agents of serological group a were most frequently isolated from the patients with the generalized forms of meningococcus infection. the percentage of detection of meningococci of serological group a was the greatest in the patients and much less in the carriers in and outsi ...1976136161
activity in vitro of ten antimicrobial agents against neisseria gonorrhoeae. a study of the correlation between the sensitivities.105 belgian strains of neisseria gonorrhoeae were tested for their sensitivity to penicillin, ampicillin, rifampicin, erythromycin, tetracycline, streptomycin, spectinomycin, sulphamethoxazole, trimethroprim, and a combination of sulphamethoxazole and trimethroprim in a 5:1 ratio. distribution and median values of minimum inhibitory concentrations (mics) are given and discussed. 42 per cent. of strains were relatively resistant to penicillin (mic greater than or equal to 0-04 mug/ml.), but only ...1976136290
[epidemiologic analysis morbidity with meningococcal infections in the ussr].the authors present the analysis of the incidence of epidemic cerebrospinal meningitis in the ussr from 1937 to 1974, and of meningococcus infection from 1965 to 1974. a rise of the meningococcus infection incidence from 1969 to 1974 was recorded 28 years after the elevation of 1940-1942 and was 1.5 times below this latter rise. the rise in 1969-1974 was characterized by marked signs peculiar to the infection with the droplet transmission mechanism; among those who contracted the disease prevale ...1976139815
spectinomycin-resistant neisseria gonorrhoeae.neisseria gonorrhoeae resistant to high levels of spectinomycin (more than 2,048 microng/ml), were isolated from specimens obtained from a patient with urethritis. the bacterial resistance to spectinomycin is probably due to ribosomal changes that are a result of a chromosomal mutation. if spectinomycin fails to cure gonorrhea, spectinomycin resistance should be considered.1977140251
[occurrence of penicillin-resistant gonococci]. 1977142209
[spectinomycin-dehydrochloride-pentahydrate--introduction of a substance]. 1977142380
[resistance of neisseria gonorrheae to streptomycin]. 1977142391
the bactericidal action of spectinomycin on neisseria gonorrhoeae. 1977142756
low back pain due to neisseria prostatitis: report of three cases.after a short term of employment in a new job, 3 young heroin addicts became disabled from low back pain due to neisseria gonorrhea prostatitis. each returned to work after a few weeks of antibiotic therapy without symptoms following proper diagnosis. these patients demonstrate the importance of a careful history and thorough examination of the patient with low back pain including a rectal examination of the prostate gland.1977144040
[therapy of acute gonorrhea].since the appearance of totally resistant, penicillinase producing gonococci, penicillin should no longer be considered first choice in the treatment of acute gonorrhea. in order to limit further extension of resistant strains, thiamphenicol (urfamycin 2,5 p.o. or 0,75 i.m.) or spectinomycin (trobicin 2,0 i.m.) are suggested as replacements for penicillin.1977144315
spectinomycin hydrochloride in the treatment of gonorrhoea: its effect on associated chlamydia trachomatis infections.sixty-three heterosexual men were successfully treated with a single injection of spectinomycin hydrochloride 2 g for urethral infections with neisseria gonorrhoeae. chlamydia trachomatis was recovered from the urethra of 11 of these men both before and after treatment. in six men, the organism was isolated after but not before treatment. no isolates were obtained from the remaining men either before or after treatment. all 17 of the men who yielded c. trachomatis developed post-gonococcal ureth ...1977144543
acute pelvic inflammatory disease: characteristics of patients with gonococcal and nongonococcal infection and evaluation of their response to treatment with aqueous procaine penicillin g and spectinomycin hydrochloride. 1977145658
[penicillinase-producing neisseria gonorrhoeae].the present state of epidemiology and the microbiology of beta-lactamase-producing n. gonorrhoeae are reviewed. methods of identification of such strains and therapeutic consequences are discussed.1977146026
penicillinase-producing neisseria gonorrhoeae: results of surveillance in the united states.in september 1976 the center for disease control (atlanta, georgia) initiated surveillance for cases of infection due to penicillinase-productin neisseria gonorrhoeae in the united states. one hundred ninety-one cases of penicillinase-producing gonococcal infection were confirmed through june 30, 1977. of 177 cases for which histories of sexual exposure were available, 69 were traced to sexual contact in the far east, and one was traced to sexual contact in west africa. of 181 cases for which cl ...1978146725
allergic contact dermatitis due to n,n-dimethyl-para-phenylenediamine in bacteriology technicians.three cases of allergic contact dermatitis due to n,n-dimethyl-para-phenylenediamine in a bacteriology laboratory are presented. this chemical, a dye closely related to the common contact allergen para-phenylenediamine, is used in laboratories to screen bacterial culture plates for neisseria gonorrhoeae. the three patients had strongly positive patch test reactions to n,n-dimethyl-para-phenylenediamine, but had negative reactions to para-phenylenediamine. a brief discussion of allergic contact c ...1978147159
[extragenital gonococcal infections. a review].in many cases gonorrhea is overlooked and not treated due to an unusual course of the disease. the longer this infection exists the greater is the danger of dissemination of the gonococci. gonorrhea, if not diagnosed, may cause a series of local and general clinical manifestations, such as: the dermatitis-arthritis syndrome whose pathogenesis is not yet completely clarified: the fitz-hugh-curtis syndrome which is often seen in females with chronic gonococcal adnexitis;gonococcal pharyngitis whi ...1978149748
[sensitivity to antibiotics of neisseria gonorrhoeae in rwanda]. 1978150261
cross-canada survey of susceptibility of neisseria gonorrhoeae isolates to six antimicrobial agents.the minimum inhibitory concentrations (mic's) of penicillin, ampicillin, tetracycline, erythromycin, spectinomycin and sulfadiazine were determined for 732 isolates of neisseria gonorrhoeae collected in 1973-74. comparison of the results of this survey with data from other canadian studies showed that the percentage of isolates resistant to tetracycline had not changed since 1966, but that the percentage of erythromycin-resistant isolates had decreased. after an initial increase in 1966 the perc ...1978150305
survey for immune complexes in disseminated gonococcal arthritis-dermatitis syndrome.seventeen patients with characteristic disseminated gonococcal arthritis-dermatitis syndrome were studied for the presence of immune complexes, and circulating gonococcal antigen and antibody. the two immune complex techniques, monoclonal rheumatoid factor assay and cryoglobulin survey, did not reveal any consistent abnormalities. complement levels (ch50, c'3, c'4) were not consistent with peripheral consumption except in 2 patients with coinciding systemic lupus erythematosus. gonococcal antibo ...1979153144
[a swedish case of beta lactamase producing gonococci?]. 1979153996
antibiotic susceptibility of neisseria gonorrhoeae isolated in johannesburg.the susceptibility of 175 clinical isolates of neisseria gonorrhoeae to penicillin g, ampicillin, erythromycin, tetracycline and spectinomycin was determined. almost one-fifth of strains were relatively resistant to penicillin g. relative resistance to penicillin g was significantly correlated with resistance to ampicillin, tetracycline and erythromycin, but not with resistance to spectinomycin. no penicillinase-producing or spectinomycin-resistant strains were encountered in this study. the rel ...1978154172
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