| peri-implant response and microflora in organ transplant patients 1 year after prosthetic loading: a prospective controlled study. | a recent study conducted in humans demonstrated for the first time that bone loss in the immediate period after implant insertion before loading did not significantly differ in organ transplant recipients with respect to normal subjects. | 2015 | 24612063 |
| clinical and microbiological effects of levofloxacin in the treatment of chronic periodontitis: a randomized, placebo-controlled clinical trial. | the aim of the present study was to evaluate the clinical and microbiological effect of systemic levofloxacin (lfx) as an adjunct to scaling and root planing (srp) in patients with chronic periodontitis (cp). | 2015 | 24574052 |
| inflammatory bone loss in experimental periodontitis induced by aggregatibacter actinomycetemcomitans in interleukin-1 receptor antagonist knockout mice. | the interleukin-1 receptor antagonist (il-1ra) binds to il-1 receptors and inhibits il-1 activity. however, it is not clear whether il-1ra plays a protective role in periodontal disease. this study was undertaken to compare experimental periodontitis induced by aggregatibacter actinomycetemcomitans in il-1ra knockout (ko) mice and wild-type (wt) mice. computed tomography (ct) analysis and hematoxylin-and-eosin (h&e) and tartrate-resistant acid phosphatase (trap) staining were performed. in addit ... | 2014 | 24566623 |
| diverse toll-like receptors mediate cytokine production by fusobacterium nucleatum and aggregatibacter actinomycetemcomitans in macrophages. | toll-like receptors (tlrs) orchestrate a repertoire of immune responses in macrophages against various pathogens. fusobacterium nucleatum and aggregatibacter actinomycetemcomitans are two important periodontal pathogens. in the present study, we investigated tlr signaling regulating cytokine production of macrophages in response to f. nucleatum and a. actinomycetemcomitans. tlr2 and tlr4 are redundant in the production of cytokines (interleukin-6 [il-6] and tumor necrosis factor alpha [tnf-α]) i ... | 2014 | 24566622 |
| a gene cluster for the synthesis of serotype g-specific polysaccharide antigen in aggregatibacter actinomycetemcomitans. | aggregatibacter actinomycetemcomitans is an important pathogen related to aggressively progressive periodontal breakdown in adolescents and adults. the species can be divided into six serotypes (a-f) according to their surface carbohydrate antigens. recently, a new serotype g of a. actinomycetemcomitans was proposed. the aim of the present study was to sequence the gene cluster associated with the biosynthesis of the serotype g-specific polysaccharide antigen and develop serotype-specific primer ... | 2014 | 24562973 |
| photodynamic therapy during supportive periodontal care: clinical, microbiologic, immunoinflammatory, and patient-centered performance in a split-mouth randomized clinical trial. | this study investigates the effect of photodynamic therapy (pdt) as monotherapy during supportive periodontal therapy. | 2014 | 24555751 |
| [dissertations 25 years after date 37. susceptibility to periodontal diseases]. | in the eighties of the former century it was observed that individuals had different modes of development of periodontitis, largely for unknown reasons. it was assumed that periodontal disease developed as a result of the presence of virulent micro-organisms in combination with an inadequate host response. the concept of this (im)balance in host parasite interactions developed further, in part because of new research techniques. with respect to oral bacteria it was shown that periodontal pathoge ... | 2013 | 24555252 |
| prevalence of periodontitis among the adolescents aged 15-18 years in mangalore city: an epidemiological and microbiological study. | periodontitis is a group of inflammatory diseases affecting the supporting tissues of the tooth. both aggressive periodontitis (ap) and chronic periodontitis (cp) have a multifactorial etiology, with dental plaque as the initiating factor. however, the initiation and progression of periodontitis are influenced by other factors including microbiologic, social and behavioral and systemic and genetic factors. the prevalence of periodontal diseases varies in different regions of the world according ... | 2013 | 24554891 |
| subgingival plaque sampling after combined mechanical and antibiotic nonsurgical periodontal therapy. | this study aimed to make a comparison of two sampling strategies of subgingival plaque after combined mechanical-antibiotic periodontal therapy. | 2015 | 24554003 |
| the cytolethal distending toxin of aggregatibacter actinomycetemcomitans inhibits macrophage phagocytosis and subverts cytokine production. | aggregatibacter actinomycetemcomitans is an important periodontal pathogen that can participate in periodontitis and other non-oral infections. the cytolethal distending toxin (cdt) is among the virulence factors produced by this bacterium. the cdt is also secreted by several mucosa-associated gram-negative pathogens and may play a role in perpetuating the infection by modulating the immune response. although the toxin targets a wide range of eukaryotic cell types little is known about its activ ... | 2014 | 24548424 |
| biodegradable nanofibrous drug delivery systems: effects of metronidazole and ciprofloxacin on periodontopathogens and commensal oral bacteria. | the purposes of this study were to fabricate biodegradable polydioxanone (pds ii®) electrospun periodontal drug delivery systems (hereafter referred to as matrices) containing either metronidazole (met) or ciprofloxacin (cip) and to investigate the effects of antibiotic incorporation on both periodontopathogens and commensal oral bacteria. | 2014 | 24535074 |
| differential transcriptional regulation of aggregatibacter actinomycetemcomitans lsracdbfg and lsrrk operons by integration host factor protein. | we previously showed that the aggregatibacter actinomycetemcomitans lsracdbfg and lsrrk operons are regulated by lsrr and cyclic amp receptor protein (crp) and that proper regulation of the lsr locus is required for optimal biofilm growth by a. actinomycetemcomitans. here, we identified sequences that reside immediately upstream from both the lsra and lsrr start codons that closely resemble the consensus recognition sequence of escherichia coli integration host factor (ihf) protein. a. actinomyc ... | 2014 | 24532769 |
| a markerless protocol for genetic analysis of aggregatibacter actinomycetemcomitans. | the genomes of different aggregatibacter actinomycetemcomitans (a actinomycetemcomitans) strains contain many strain-specific genes and genomic islands (defined as dna found in some but not all strains) of unknown functions. genetic analysis for the functions of these islands will be constrained by the limited availability of genetic markers and vectors for a actinomycetemcomitans. in this study, we tested a novel genetic approach of gene deletion and restoration in a naturally competent a actin ... | 2014 | 24530245 |
| quantification of periodontal pathogens in vascular, blood, and subgingival samples from patients with peripheral arterial disease or abdominal aortic aneurysms. | the aim of this investigation is to quantify periodontal pathogens (aggregatibacter actinomycetemcomitans, porphyromonas gingivalis, campylobacter rectus, and tannerella forsythia) in vascular, blood, and subgingival samples. as a secondary objective, two molecular bacterial identification methods (nested polymerase chain reaction [pcr] and quantitative pcr [qpcr]) are compared. | 2014 | 24502612 |
| effects of acidic sodium fluoride-treated, commercially pure titanium on periodontal pathogens and rat bone marrow cells. | the purpose of the present study was to clarify the potentiality of acidic fluoride solution in treating peri-implantitis. we examined bactericidal activity of fluoride solution against periodontal pathogens; and evaluated the effects of fluoride on titanium, and the effects on cell proliferation and differentiation of rat bone marrow cells on the fluoride-treated titanium. aggregatibacter actinomycetemcomitans and porphyromonas gingivalis were used to determine minimal inhibitory concentration ... | 2014 | 24492115 |
| cyclodextrin modulates the cytotoxic effects of chlorhexidine on microrganisms and cells in vitro. | although several studies have shown that chlorhexidine (cx) has bactericidal activity and exerts toxic effects on periodontal tissues a few studies evaluated mechanisms to reduce its adverse effects maintaining the antimicrobial properties. therefore, the aim of the present study was to investigate the in vitro antimicrobial activity and cellular cytotoxicity of cx included on cyclodextrins (cd), α, β or hp-β-cyclodextrins (hp-β-cd). the influence of cds was determined by increasing its molar ra ... | 2015 | 24491181 |
| photodynamic antimicrobial effect of safranine o on an ex vivo periodontal biofilm. | the increasing resistance of oral pathogens against antibiotic measures urgently requires new therapeutic strategies. in this context, antimicrobial photodynamic therapy (apdt) may play a crucial part in the future. the aim of the present study was to compare the antibacterial efficiency of apdt using the photosensitizer safranine o with that of chlorhexidine (0.2% chx) on an ex vivo biofilm. | 2014 | 24473989 |
| in vivo effectiveness of silicone gel sheets as barriers at the inner microgap between a prosthetic abutment and an external-hexagon implant platform. | bacterial penetration and colonization of the microgap at the implant-abutment interface have been reported in several studies. the aim of this study was to evaluate the effectiveness of placing a silicone membrane between the abutment and the implant platform in an attempt to seal the interface. | 2014 | 24451862 |
| the pga gene cluster in aggregatibacter actinomycetemcomitans is necessary for the development of natural competence in ca(2+) -promoted biofilms. | natural competence is the ability of bacteria to incorporate extracellular dna into their genomes. this competence is affected by a number of factors, including ca(2+) utilization and biofilm formation. as bacteria can form thick biofilms in the presence of extracellular ca(2+) , the additive effects of ca(2+) -promoted biofilm formation on natural competence should be examined. we evaluated natural competence in aggregatibacter actinomycetemcomitans, an important periodontal pathogen, in the co ... | 2014 | 24450419 |
| comparison of the penetration and passage of streptococcus mutans and aggregatibacter actinomycetemcomitans through membranes loaded with tetracycline, amoxicillin, and chlorhexidine: an in vitro study. | this study aimed at comparing the colonization and passage of streptococcus mutans and aggregatibacter actinomycetemcomitans (aa) through polytetrafluoroethylene (ptfe) and acellular dermal matrix (adm) membranes loaded with tetracycline, amoxicillin, and chlorhexidine. | 2014 | 24423468 |
| serum c-reactive protein and immunoglobulin g antibodies to periodontal pathogens may be effect modifiers of periodontitis and hyperglycemia. | serum c-reactive protein (crp) is elevated in both periodontitis and type 2 diabetes mellitus through inflammation. aggregatibacter actinomycetemcomitans and porphyromonas gingivalis have been found in periodontal pockets in patients with diabetes. this study examines effect modification by examining the extent to which the associations between periodontitis and hyperglycemia were different by levels of serum crp and periodontal pathogens. | 2014 | 24410292 |
| [aggregatibacter actinomycetemcomitans and porphyromonas gingivalis in aggressive periodontitis in morocco -- preliminary study]. | the microbial eatiology of aggressive perodontitis is different worldwidly. the purpose of this study was to determine the presence or absence of two anaerobic, highly pathogenic bacteria, aggregatibacter actinomycetemcomitans and porphyromonas gingivalis (p.g) in aggressive periodontitis in a moroccan population. | 2013 | 24380115 |
| correlation of aggregatibacter actinomycetemcomitans detection with clinical/immunoinflammatory profile of localized aggressive periodontitis using a 16s rrna microarray method: a cross-sectional study. | the objective of this study was to determine whether the detection of aggregatibacter actinomycetemcomitans (aa) correlates with the clinical and immunoinflammatory profile of localized aggressive periodontitis (lap), as determined by by 16s rrna gene-based microarray. | 2013 | 24376864 |
| periodontal bacteria in the genital tract: are they related to adverse pregnancy outcome? | one of the most important factors implicated in preterm birth (ptb) is acute genitourinary tract infection. the bacteria causing chronic periodontal inflammation include gram-negative rods and anaerobes similar to those found in women with bacterial vaginosis. the aim of this prospective study is to investigate the relationship between oral and vaginal microflora and preterm low birth weight. real-time polymerase chain reaction was used to detect both the presence and level of six periodontitis- ... | 2017 | 24355228 |
| simvastatin inhibits lps-induced alveolar bone loss during metabolic syndrome. | studies in recent years have shown a positive relationship between metabolic syndrome (ms) and periodontal disease (pd). given that patients with ms take statins to reduce cholesterol, and statins also have anti-inflammatory effects, it is important to determine if statin intake hinders the progression of ms-associated pd. in this study, pd was induced in zucker fat rats (zfrs), an animal model for ms, and in control lean rats by periodontal injection of aggregatibacter actinomycetemcomitans lip ... | 2014 | 24352501 |
| biology and pathogenesis of cytomegalovirus in periodontal disease. | human periodontitis is associated with a wide range of bacteria and viruses and with complex innate and adaptive immune responses. porphyromonas gingivalis, tannerella forsythia, aggregatibacter actinomycetemcomitans, treponema denticola, cytomegalovirus and other herpesviruses are major suspected pathogens of periodontitis, and a combined herpesvirus-bacterial periodontal infection can potentially explain major clinical features of the disease. cytomegalovirus infects periodontal macrophages an ... | 2014 | 24320955 |
| serotypes of aggregatibacter actinomycetemcomitans in relation to periodontal status and geographic origin of individuals-a review of the literature. | several studies have focused on the relationship among serotype distribution, ethnical status and geographic populations, and periodontal conditions. studies that have investigated the prevalence and the distribution of a. actinomycetemcomitans serotypes and the relation between the different serotypes of the bacterium and periodontal status were reviewed. | 2014 | 24316700 |
| the periodontal pathogen aggregatibacter actinomycetemcomitans affects experimental autoimmune myocarditis in mice. | recent reports assert that dental health is linked to an increased risk of cardiovascular disease. it is well known that aggregatibacter actinomycetemcomitans (a.a.) is highly associated with heart disease. indeed, we previously reported that a.a. affects the development of heart disease in a mouse model. however, no reports have clarified the relationship between a.a. and experimental autoimmune myocarditis (eam). the aim of this study was to investigate the effects of a.a. on eam in mice. eam ... | 2013 | 24309453 |
| progression of attachment loss is strongly associated with presence of the jp2 genotype of aggregatibacter actinomycetemcomitans: a prospective cohort study of a young adolescent population. | to assess the progression of attachment loss (al) during a 2-year period according to the presence of jp2 and non-jp2 genotypes of aggregatibacter actinomycetemcomitans in a ghanaian adolescent population. | 2014 | 24304011 |
| effects of areca nut extracts on phagocytosis of actinobacillus actinomycete mcomitans atcc 33384 by neutrophils in patients with chronic periondontitis. | a higher prevalence of periodontal disease among areca nut chewers than non chewers has been demonstrated. neutrophils, the first line of defence mechanism against microbial infection play an important role in maintaining the periodontal health. in this context our aim was to evaluate the effects of areca nut extracts on phagocytic activity by neutrophils isolated from gingival crevicular washing of healthy subjects and patients with chronic periodontitis. | 2013 | 24298462 |
| blue light kills aggregatibacter actinomycetemcomitans due to its endogenous photosensitizers. | the aim of this study was to demonstrate that the periodontal pathogen aggregatibacter actinomycetemcomitans (aa) can be killed by irradiation with blue light derived from a led light-curing unit due to its endogenous photosensitizers. | 2014 | 24297656 |
| in vitro evaluation of the risk of inducing bacterial resistance to disinfection treatment with photolysis of hydrogen peroxide. | the purpose of the present study was to evaluate the risk of inducing bacterial resistance to disinfection treatment with photolysis of h2o2 and comparing this with existing antibacterial agents. we tested seven antibacterial agents, including amoxicillin, cefepime hydrochloride, erythromycin, ofloxacin, clindamycin hydrochloride, ciprofloxacin hydrochloride, and minocycline hydrochloride, as positive controls for validation of the assay protocol. for all of the agents tested, at least one of th ... | 2013 | 24282582 |
| serotype-dependent response of human dendritic cells stimulated with aggregatibacter actinomycetemcomitans. | different serotypes of aggregatibacter actinomycetemcomitans have been described based on the lipopolysaccharide (lps)-o-polysaccharide antigenicity. in turn, a distinct effect of a. actinomycetemcomitans serotypes has been described on cell proliferation and pro-inflammatory cytokine production in different human cells. this study was aimed to investigate the differential dendritic cell (dc) response when stimulated with different bacterial strains belonging to the most prevalent serotypes of a ... | 2014 | 24256118 |
| does microwave sterilization of growth media involve any non-thermal effect? | fast reactions mediated by microwaves are often attributed by many to non-thermal effect. we show here that rapid formation of maillard reaction products during microwave sterilization of growth medium results from concentration effect and not any non-thermal effect. this leads to an improved method for microwave sterilization of growth media. | 2014 | 24246231 |
| quercetin inhibits inflammatory bone resorption in a mouse periodontitis model. | periodontitis is a disease that leads to bone destruction and represents the main cause of tooth loss in adults. the development of aggressive periodontitis has been associated with increased inflammatory response that is induced by the presence of a subgingival biofilm containing aggregatibacter actinomycetemcomitans. the flavonoid quercetin (1) is widespread in vegetables and fruits and exhibits many biological properties for possible medical and clinical applications such as its anti-inflamat ... | 2013 | 24246038 |
| anaerobic co-culture of mesenchymal stem cells and anaerobic pathogens - a new in vitro model system. | human mesenchymal stem cells (hmscs) are multipotent by nature and are originally isolated from bone marrow. in light of a future application of hmscs in the oral cavity, a body compartment with varying oxygen partial pressures and an omnipresence of different bacterial species i.e. periodontitis pathogens, we performed this study to gain information about the behavior of hmsc in an anaerobic system and the response in interaction with oral bacterial pathogens. | 2013 | 24223777 |
| anabolic steroids affect human periodontal health and microbiota. | this study aims to evaluate periodontal microbiological differences between systemically healthy nonsmoker males taking anabolic androgenic steroids (aass) and non-aas users and to find associations between disease severity and aas use. | 2014 | 24221579 |
| antibacterial activity of moxifloxacin on bacteria associated with periodontitis within a biofilm. | the activity of moxifloxacin was compared with ofloxacin and doxycycline against bacteria associated with periodontitis within a biofilm (single strain and mixed population) in vitro. mics and minimal bactericidal concentrations (mbcs) of moxifloxacin, ofloxacin and doxycyline were determined against single strains and mixed populations in a planktonic state. single-species biofilms of two porphyromonas gingivalis and two aggregatibacter actinomycetemcomitans strains and a multispecies biofilm c ... | 2014 | 24217128 |
| leukotoxicity of aggregatibacter actinomycetemcomitans in generalized aggressive periodontitis in brazilians and their family members. | the purpose of this study was to examine the leukotoxin promoter types of aggregatibacter actinomycetemcomitans clones in subjects with generalized aggressive periodontitis (gagp) and in their family members (fm). | 2015 | 24212989 |
| leukotoxin kills rodent wbc by targeting leukocyte function associated antigen 1. | leukotoxin is a protein that is secreted by aggregatibacter actinomycetemcomitans and that primarily targets the active form of leukocyte function associated antigen 1 (lfa1) on wbc. because of its specificity for wbc, leukotoxin is being developed as a novel biologic treatment for hematologic malignancies and autoimmune-inflammatory diseases. early studies indicated that leukotoxin is specific for wbc from humans and old world primates. in the current study, we used in vivo and in vitro assays ... | 2013 | 24209968 |
| protective effects of human lactoferrin during aggregatibacter actinomycetemcomitans-induced bacteremia in lactoferrin-deficient mice. | aggregatibacter actinomycetemcomitans, a periodontopathogen, has been associated with several systemic diseases. herein, we report the protective effect of human lactoferrin (hlf) during a. actinomycetemcomitans bacteremia in lactoferrin knockout (lfko(-/-)) mice. the prophylactic, concurrent, and therapeutic intravenous (i.v.) administrations of hlf significantly cleared the bacteria from blood and organs. nevertheless, all modes of hlf administration significantly decreased the concentrations ... | 2014 | 24189260 |
| microbial composition of atherosclerotic plaques. | the association of infections such as periodontitis with atherosclerotic diseases is well documented. in spite of the high diversity of the human oral microbiota, and its close contact with the circulatory system, few oral species were detected in atherosclerotic plaques. thus, we attempted to evaluate the microbial diversity of atherosclerotic plaques from patients with different periodontal conditions, submitted to endarterectomy by a broad-range microbial method. | 2014 | 24188425 |
| antimicrobial photodynamic efficiency of novel cationic porphyrins towards periodontal gram-positive and gram-negative pathogenic bacteria. | the gram-negative aggregatibacter actinomycetemcomitans and fusobacterium nucleatum are major causative agents of aggressive periodontal disease. due to increase in the number of antibiotic-resistant bacteria, antimicrobial photodynamic therapy (apdt) seems to be a plausible alternative. in this work, photosensitization was performed on gram-positive and gram-negative bacteria in pure culture using new-age cationic porphyrins, namely mesoimidazolium-substituted porphyrin derivative (imp) and pyr ... | 2014 | 24164211 |
| differential transcription of virulence genes in aggregatibacter actinomycetemcomitans serotypes. | aggregatibacter actinomycetemcomitans serotypes are clearly associated with periodontitis or health, which suggests distinct strategies for survival within the host. | 2013 | 24159369 |
| does photodynamic therapy enhance standard antibacterial therapy in dentistry? | the aim of this study was to assess whether or not photodynamic therapy enhanced standard antibacterial therapy in dentistry. | 2013 | 24138192 |
| the effect of proatherogenic pathogens on adipose tissue transcriptome and fatty acid distribution in apolipoprotein e-deficient mice. | chronic infections have been demonstrated to maintain low-grade systemic inflammation and associate with atherosclerosis. we studied the inflammation- and lipid homeostasis-related effects of aggregatibacter actinomycetemcomitans (aa) and chlamydia pneumoniae (cpn) infections on the epididymal and inguinal adipose tissue (at) transcriptomes and fatty acid distribution in apolipoprotein (apo) e-deficient mice. chow-fed apoe-deficient mice were exposed to 1) chronic intranasal infection with c. pn ... | 2013 | 24131481 |
| simvastatin inhibits lipopolysaccharide-induced osteoclastogenesis and reduces alveolar bone loss in experimental periodontal disease. | statins are inhibitors of 3-hydroxy-3-methylglutaryl coenzyme a reductase and have anti-inflammatory effects independent of cholesterol lowering. recent clinical studies have indicated that statin intake has a beneficial effect on periodontal disease. however, the underlying mechanisms have not been well understood. in the current study, we employed a rat model with lipopolysaccharide (lps)-induced periodontal disease and determined the effect of simvastatin, a commonly prescribed statin, on ost ... | 2014 | 24117880 |
| bacterial infection increases periodontal bone loss in diabetic rats through enhanced apoptosis. | periodontal disease is the most common osteolytic disease in humans and is significantly increased by diabetes mellitus. we tested the hypothesis that bacterial infection induces bone loss in diabetic animals through a mechanism that involves enhanced apoptosis. type ii diabetic rats were inoculated with aggregatibacter actinomycetemcomitans and treated with a caspase-3 inhibitor, zdevd-fmk, or vehicle alone. apoptotic cells were measured with tunel; osteoblasts and bone area were measured in h& ... | 2013 | 24113454 |
| oral community interactions of filifactor alocis in vitro. | filifactor alocis is a gram positive anaerobe that is emerging as an important periodontal pathogen. in the oral cavity f. alocis colonizes polymicrobial biofilm communities; however, little is known regarding the nature of the interactions between f. alocis and other oral biofilm bacteria. here we investigate the community interactions of two strains of f. alocis with streptococcus gordonii, fusobacterium nucleatum, porphyromonas gingivalis and aggregatibacter actinomycetemcomitans, organisms w ... | 2013 | 24098460 |
| antimicrobial activity of isothiocyanates (itcs) extracted from horseradish (armoracia rusticana) root against oral microorganisms. | the antimicrobial activity of isothiocyanates (itcs) extracted from horseradish root was investigated against oral microorganisms: 6 strains of facultative anaerobic bacteria, streptococcus mutans, streptococcus sobrinus, lactobacillus casei, staphylococcus aureus, enterococcus faecalis and aggregatibacter actinomycetemcomitans; one strain of yeast, candida albicans, and 3 strains of anaerobic bacteria, fusobacterium nucleatum, prevotella nigrescens, and clostridium perfringens. the itcs extract ... | 2013 | 24077540 |
| anti-inflammatory and wound healing potential of citrus auraptene. | auraptene is the most abundant naturally occurring geranyloxycoumarin. it is primarily isolated from plants in the rutaceae family, many of which, like citrus fruits, are used as food in many countries. auraptene is a biologically active secondary metabolite with valuable properties. the aim of our study was to identify novel properties of auraptene with potential for managing periodontal diseases, an inflammatory disease of bacterial origin affecting the tissues surrounding and supporting the t ... | 2013 | 24070132 |
| micrornas responsive to aggregatibacter actinomycetemcomitans and porphyromonas gingivalis lps modulate expression of genes regulating innate immunity in human macrophages. | micrornas (mirnas) are a class of small, noncoding rnas that regulate post-transcriptional expression of their respective target genes and are responsive to various stimuli, including lps. here we examined the early (4 h) mirna responses of thp1-differentiated macrophages challenged with lps derived from the periodontal pathogens, aggregatibacter actinomycetemcomitans, porphyromonas gingivalis or environmentally-modified lps obtained from p. gingivalis grown in cigarette smoke extract. predicted ... | 2014 | 24062196 |
| comparing the efficacy of hyper-pure chlorine-dioxide with other oral antiseptics on oral pathogen microorganisms and biofilm in vitro. | this study examines the antibacterial properties of sodium hypochlorite (naocl), chlorhexidine gluconate (chx), listerine®, and high purity chlorine dioxide (solumium, clo2) on selected common oral pathogen microorganisms and on dental biofilm in vitro. antimicrobial activity of oral antiseptics was compared to the gold standard phenol. we investigated streptococcus mutans, lactobacillus acidophilus, enterococcus faecalis, veillonella alcalescens, eikenella corrodens, actinobacillus actinomycete ... | 2013 | 24060558 |
| salivary detection of periodontopathic bacteria in fanconi's anemia patients. | fanconi's anemia (fa) is characterized by bone marrow failure and can lead to infections such as periodontal disease. the aim of this study was to compare the prevalence of four periodontopathic bacteria including aggregatibacter actinomycetemcomitans, porphyromonas gingivalis, fusobacterium nucleatum and treponema denticola in saliva samples from children with and without fa. paraffin-stimulated saliva samples were collected from 71 children and adolescents, aged 6-18 years old. the samples wer ... | 2013 | 24055631 |
| molecular detection of aggregatibacter actinomycetemcomitans and porphyromonas gingivalis in subgingival plaque of healthy young children. | the aim of the present study was to evaluate the presence of aggregatibacter actinomycetemcomitans (a. actinomycetemcomitans) and porphyromonas gingivalis (p. gingivalis) in subgingival plaque of healthy young children aged between 3 and 15 years using polymerase chain reaction (pcr) and to compare their presence in children in their primary, mixed and permanent dentitions. | 2013 | 24046982 |
| biomarkers of periodontitis and inflammation in ischemic stroke: a case-control study. | periodontitis is a common infectious disease associated with increased risk for ischemic stroke though presently unclear mechanisms. in a case-control study, we investigated salivary levels of four periodontal pathogens, as well as systemic and local inflammatory markers. the population comprised 98 patients with acute ischemic stroke (mean ± sd, 68.2 ± 9.7 yrs; 45.9% women) and 100 healthy controls (69.1 ± 5.2 yrs; 47.0% women). patients were more often edentulous and had fewer teeth than contr ... | 2014 | 24045341 |
| detection of putative periodontopathic bacteria in type 1 diabetic and healthy children: a comparative study. | the aim of this study was to compare and assess the risk of periodontitis due to the presence of four putative periodontopathic bacteria (porphyromonas gingivalis, treponema denticola, tannerella forsythia, and aggregatibacter actinomycetemcomitans) in type 1 diabetic and healthy children. | 2013 | 24025882 |
| probing bacterial metabolism during infection using high-resolution transcriptomics. | a fundamental aspect of most infectious diseases is the need for the invading microbe to proliferate in the host. however, little is known about the metabolic pathways required for pathogenic microbes to colonize and persist in their hosts. in this study, we used rna sequencing (rna-seq) to generate a high-resolution transcriptome of the opportunistic pathogen aggregatibacter actinomycetemcomitans in vivo. we identified 691 a. actinomycetemcomitans transcriptional start sites and 210 noncoding r ... | 2013 | 23974023 |
| bacterial adhesion to antibiotic-loaded guided tissue regeneration membranes - a scanning electron microscopy study. | bacterial contamination of sites undergoing guided tissue regeneration (gtr) therapy may reduce the efficiency of periodontal regeneration. this study compared bacterial adhesion onto various gtr membranes incorporated with antibiotics. | 2015 | 23969040 |
| aggregatibacter actinomycetemcomitans biofilm killing by a targeted ciprofloxacin prodrug. | a ph-sensitive ciprofloxacin prodrug was synthesized and targeted against biofilms of the periodontal pathogen aggregatibacter actinomycetemcomitans (aa). the dose required to reduce the viability of a mature biofilm of aa by ~80% was in the range of ng cm(-2) of colonized area (mean biofilm density 2.33 × 10(9) cells cm(-2)). a mathematical model was formulated that predicts the temporal change in the concentration of ciprofloxacin in the aa biofilm as the drug is released and diffuses into the ... | 2013 | 23952779 |
| identification of a novel bacterial outer membrane interleukin-1β-binding protein from aggregatibacter actinomycetemcomitans. | aggregatibacter actinomycetemcomitans is a gram-negative opportunistic oral pathogen. it is frequently associated with subgingival biofilms of both chronic and aggressive periodontitis, and the diseased sites of the periodontium exhibit increased levels of the proinflammatory mediator interleukin (il)-1β. some bacterial species can alter their physiological properties as a result of sensing il-1β. we have recently shown that this cytokine localizes to the cytoplasm of a. actinomycetemcomitans in ... | 2013 | 23936223 |
| a comparison of aggregatibacter actinomycetemcomitans (aa) virulence traits in a rat model for periodontal disease. | our aim was to explore the effects of cytolethal distending toxin (cdt) in a well established rat model of periodontal disease where leukotoxin (ltxa) was thought to have no known effect. in vitro studies, were used to assess cdtb activity using aa leukotoxin as a negative control. these studies showed that both cdtb and ltxa (unexpectedly) exerted significant effects on cd4(+) t cells. as a result we decided to compare the effects of these two prominent aa virulence factors on bone loss using o ... | 2013 | 23936002 |
| in vitro evaluation of dispersinb on methicillin-resistant staphylococcus pseudintermedius biofilm. | methicillin resistant staphylococcus pseudintermedius (mrsp) is an important canine pathogen that has been shown to produce biofilm in vitro. biofilm production may be an important virulence factor and methods to eliminate biofilm-associated infections are required. an enzyme of aggregatibacter actinomycetemcomitans, dispersinb, has been shown to degrade the extracellular matrix in the biofilm of a variety of bacteria including staphylococcus aureus and staphylococcus epidermidis. the objective ... | 2013 | 23932310 |
| bacterial promotion of bisphosphonate-induced osteonecrosis in wistar rats. | clinically, bisphosphonate-related osteonecrosis (bron) only occurs in the jaw (bronj). we aimed to determine differences between the jaw and other bones, as well as the relationship between periodontal pathogens and bron. twelve male wistar rats were divided into two groups: group z (n=6) were subcutaneously injected with zoledronic acid weekly for 4 weeks; group c (n=6) were injected with saline. one week after the final injection, rats in both groups were divided into three subgroups: aa subg ... | 2013 | 23932020 |
| cytolethal distending toxin in isolates of aggregatibacter actinomycetemcomitans from ghanaian adolescents and association with serotype and disease progression. | the cytolethal distending toxin (cdt) is a highly conserved exotoxin that are produced by a number of gram negative bacteria, including aggregatibacter actinomycetemcomitans, and affects mammalian cells by inhibiting cell division and causing apoptosis. a complete cdt-operon is present in the majority of a. actinomycetemcomitans, but the proportion of isolates that lack cdt-encoding genes (a, b and c) varies according to the population studied. the objectives of this study were to examine seroty ... | 2013 | 23922633 |
| myd88 is essential for alveolar bone loss induced by aggregatibacter actinomycetemcomitans lipopolysaccharide in mice. | aggregatibacter actinomycetemcomitans is a gram-negative bacteria highly associated with localized aggressive periodontitis. the recognition of microbial factors, such as lipopolysaccharide from a. actinomycetemcomitans ((aa)lps), in the oral environment is made mainly by surface receptors known as toll-like receptors (tlr). tlr4 is the major lps receptor. this interaction leads to the production of inflammatory cytokines by myeloid differentiation primary-response protein 88 (myd88) -dependent ... | 2013 | 23906379 |
| periodontal clinical and microbiological data in desquamative gingivitis patients. | a series of patients affected by desquamative gingivitis (dg) was investigated in order to evaluate relation patterns among clinical parameters relevant to plaque-induced periodontitis, periodontal microbiological data and the presence of dg lesions. | 2014 | 23900791 |
| aggregatibacter actinomycetemcomitans lipopolysaccharide stimulated epithelial cells produce interleukin-15 that regulates t cell activation. | oral epithelial cells act not only as mechanical barriers but also as immunological barriers by producing various mediators such as cytokines. since, in periodontal disease, limited information is available regarding the role of oral epithelial cell-derived cytokines on t cell activation, we investigated the responses of human t cells (jurkat cell) to cytokines in kb cells (an oral epithelial cell line) that had been stimulated with aggregatibacter actinomycetemcomitans lipopolysaccharide (lps). | 2013 | 23890451 |
| molecular microbiological evaluation of subgingival biofilm sampling by paper point and curette. | the present clinical study aimed to investigate if there are differences in microbiological outcomes dependent on the subgingival biofilm collection method. subgingival biofilm samples were collected from the four deepest pockets (>5 mm) of 17 patients with aggressive periodontitis (agp) and 33 patients with chronic periodontitis (cp), first by paper point and thereafter by curette. samples obtained with the same method were pooled together from each patient and forwarded for molecular microbiol ... | 2014 | 23879704 |
| green tea extract as a local drug therapy on periodontitis patients with diabetes mellitus: a randomized case-control study. | the green tea extract is a naturally occurring product having beneficial effects that counteract with the pathobiological features of periodontitis and diabetes mellitus. hence, the present study was aimed at incorporation of green tea extract into hydroxylpropyl methylcellulose and investigates its efficacy in chronic periodontitis patients associated with and without diabetes mellitus. | 2013 | 23869126 |
| occurrence of red complex microorganisms and aggregatibacter actinomycetemcomitans in patients with diabetes. | the aim of the present study was to analyze the occurrence of porphyromonas gingivalis (p. gingivalis), tannerella forsythia (t. forsythia), treponema denticola (t. denticola), and aggregatibacter actinomycetemcomitans (a. actinomycetemcomitans) in patients with diabetes. | 2015 | 23857867 |
| characterization of periodontal biofilm in down syndrome patients: a comparative study. | the aim of this study was to characterize the main periodontal bacterial species in down syndrome (ds) patients with and without periodontitis. | 2013 | 23855174 |
| long-term results after treatment of periodontitis in patients with papillon-lefèvre syndrome: success and failure. | retrospective evaluation of periodontal status in patients with papillon-lefèvre syndrome (pls) observed for ≥10 years; identification of factors that may influence treatment outcome; and reporting of the outcome of dental implants in four pls patients. | 2013 | 23829197 |
| quantification of key periodontal pathogens in insulin-dependent type 2 diabetic and non-diabetic patients with generalized chronic periodontitis. | periodontitis is a common problem in patients with diabetes mellitus (dm), however, differences in the putative periodontal pathogens in subjects with dm compared to non-dm subjects are still inconclusive. the red complex, which includes porphyromonas gingivalis, treponema denticola, and tannerella forsythia, encompasses the most important pathogens in adult periodontal disease. the aim of the present study was to compare cell numbers of p. gingivalis, t. denticola, t. forsythia and aggregatibac ... | 2013 | 23827459 |
| genomic stability of aggregatibacter actinomycetemcomitans during persistent oral infection in human. | the genome of periodontal pathogen aggregatibacter actinomycetemcomitans exhibits substantial variations in gene content among unrelated strains primarily due to the presence or absence of genomic islands. this study examined the genomic stability of a. actinomycetemcomitans during its persistent infection in the same host. four pairs of a. actinomycetemcomitans strains, each pair isolated from an individual over time (0-10 years), were examined for their gains/losses of genes by whole genome se ... | 2013 | 23824402 |
| effects of chitosan particles in periodontal pathogens and gingival fibroblasts. | chitosan is a naturally derived polymer with antimicrobial and anti-inflammatory properties. however, studies evaluating the role of chitosan in the control of periodontal pathogens and the responses of fibroblasts to inflammatory stimuli are lacking. in the present study, we analyzed whether chitosan particles may inhibit the growth of periodontal pathogens and modulate the inflammatory response in human gingival fibroblasts. chitosan particles were generated through ionic gelation. they inhibi ... | 2013 | 23788611 |
| effect of photoactivated disinfection with a light-emitting diode on bacterial species and biofilms associated with periodontitis and peri-implantitis. | to determine the effect of photoactivated disinfection (pad) using toluidine blue and a light-emitting diode (led) in the red spectrum (wave length at 625-635 nm) on species associated with periodontitis and peri-implantitis and bacteria within a periodontopathic biofilm. | 2013 | 23769282 |
| oil essential mouthwashes antibacterial activity against aggregatibacter actinomycetemcomitans: a comparison between antibiofilm and antiplanktonic effects. | the aim of this work is to determine the antibacterial activity of three marketed mouthwashes on suspended and sessile states of aggregatibacter actinomycetemcomitans. the efficacy of two commonly used products in clinical practice, containing essential oils as active ingredients (menthol, thymol, methyl salicylate, and eucalyptol) in association with or without alcohol, has been evaluated in comparison with a chlorhexidine-based mouthwash. the microtiter plate assay, in order to obtain a spectr ... | 2013 | 23762059 |
| the connection between ruptured cerebral aneurysms and odontogenic bacteria. | patients with ruptured saccular intracranial aneurysms have excess long-term mortality due to cerebrovascular and cardiovascular diseases compared with general population. chronic inflammation is detected in ruptured intracranial aneurysms, abdominal aortic aneurysms and coronary artery plaques. bacterial infections have been suggested to have a role in the aetiology of atherosclerosis. bacteria have been detected both in abdominal and coronary arteries but their presence in intracranial aneurys ... | 2013 | 23761916 |
| clinical and microbiologic effect of nonsurgical periodontal therapy on patients with chronic or aggressive periodontitis. | to evaluate the changes in the clinical parameters, and the prevalence and quantities of three major periodontopathic bacteria, namely porphyromonas gingivalis, aggregatibacter actinomycetemcomitans, and tannerella forsythia, in subgingival plaque collected from patients with generalized chronic periodontitis (gcp) or generalized aggressive periodontitis (gagp) in response to nonsurgical periodontal therapy. | 2013 | 23757461 |
| a new functional site w115 in cdta is critical for aggregatibacter actinomycetemcomitans cytolethal distending toxin. | aggregatibacter actinomycetemcomitans, a specific pathogen of localized aggressive periodontitis, produces a cytolethal distending toxin (cdt) that arrests eukaryotic cells irreversibly in g0/g1 or g2/m phase of the cell cycle. although structural studies show that the aromatic patch region of cdta plays an important role in its biological activity, the functional sites of cdta have not been firmly established. in this study, site-specific mutagenesis strategy was employed for cdta point mutatio ... | 2013 | 23755273 |
| [different expression of cytokines induced by actinobacillus actinomycetemcomitans lipopolysaccharide in monocytes/macrophages from different organs of rabbits]. | to investigate the expression of cytokines induced by actinobacillus actinomycetemcomitans lipopolysaccharide (aa-lps) in monocytes/macrophages from different organs of rabbits. | 2013 | 23751530 |
| clinical results after nonsurgical therapy in aggressive and chronic periodontitis. | this study aims to analyze factors influencing treatment results in aggressive (agp) and chronic (chp) periodontitis. | 2014 | 23749245 |
| antimicrobial properties and dentin bonding strength of magnesium phosphate cements. | the main objective of this work was to assess the antimicrobial properties and the dentin-bonding strength of novel magnesium phosphate cements (mpc). three formulations of mpc, consisting of magnesium oxide and a phosphate salt, nh4h2po4, nah2po4 or a mixture of both, were evaluated. as a result of the setting reaction, mpc transformed into either struvite (mgnh4po4·6h2o) when nh4h2po4 was used or an amorphous magnesium sodium phosphate when nah2po4 was used. the mpc had appropriate setting tim ... | 2013 | 23747324 |
| rheumatoid arthritis is an autoimmune disease caused by periodontal pathogens. | a statistically significant association between periodontal disease (pd) and systemic diseases has been identified. rheumatoid arthritis (ra), which is a chronic inflammatory joint disease, exhibits similar characteristics and pathogenesis to pd. the association between ra and pd has been investigated, and numerous publications on this subject exist. approximately 20 bacterial species have been identified as periodontal pathogens, and these organisms are linked to various types of pd. the most a ... | 2013 | 23737674 |
| serum antibody responses to periodontal microbiota in chronic and aggressive periodontitis: a postulate revisited. | the authors revisited the 1999 international workshop postulate of robust serum antibody responses to infecting agents in localized aggressive periodontitis (lagp) and weak responses in generalized aggressive periodontitis (gagp). antibody responses were further examined in localized and generalized chronic periodontitis (lcp and gcp). | 2014 | 23725029 |
| porphyromonas gingivalis, treponema denticola and toll-like receptor 2 are associated with hypertensive disorders in placental tissue: a case-control study. | to explore the associations between the presence of periodontal pathogens and the expression of toll-like receptors (tlr-2 and tlr-4) in the placental tissue of patients with hypertensive disorders compared to the placentas of healthy normotensive patients. | 2013 | 23711357 |
| a randomized controlled clinical trial on the clinical and microbiological efficacy of systemic satranidazole in the treatment of chronic periodontitis. | the present clinical trial was designed to investigate the effectiveness of systemic satranidazole (sz) as an adjunct to scaling and root planing (srp) in the treatment of chronic periodontitis. | 2013 | 23705535 |
| antibiotic resistance in human chronic periodontitis microbiota. | patients with chronic periodontitis (cp) may yield multiple species of putative periodontal bacterial pathogens that vary in their antibiotic drug susceptibility. this study determines the occurrence of in vitro antibiotic resistance among selected subgingival periodontal pathogens in patients with cp. | 2014 | 23688097 |
| oxidative stress and antibody levels to periodontal bacteria in adults: the nagasaki islands study. | periodontitis is a chronic inflammatory disease of the tissues supporting the teeth and is caused by subgingival plaque. systemic increases in reactive oxygen species are involved in pathogenesis of periodontitis. this study addressed the relationship between levels of serum oxidative stress and antibodies against putative periodontopathic bacteria and their association with periodontal conditions, in a community-based study. | 2014 | 23679350 |
| phototoxic effect of blue light on the planktonic and biofilm state of anaerobic periodontal pathogens. | the purpose of this study was to compare the phototoxic effects of blue light exposure on periodontal pathogens in both planktonic and biofilm cultures. | 2013 | 23678390 |
| periodontopathogen and epstein-barr virus-associated periapical periodontitis may be the source of retrograde infectious peri-implantitis. | herpesviral-bacterial synergism may play a role in periodontitis and peri-implantitis etiopathogenesis. periapical periodontitis (pp) lesions can predict future apical peri-implantitis complications. | 2015 | 23675952 |
| antibiotic susceptibility of aggregatibacter actinomycetemcomitans jp2 in a biofilm. | localized aggressive periodontitis (lagp) is an inflammatory disease associated with specific bacteria, particularly aggregatibacter actinomycetemcomitans, which can result in early tooth loss. the bacteria grow as a biofilm known as subgingival plaque. treatment includes mechanical debridement of the biofilm, often associated with empirical antibiotic treatment. | 2013 | 23671757 |
| vertebral and pulmonary actinomycosis mimicking metastatic lung cancer. | actinomycosis of the spine with spinal cord compression is rare. only 22 cases are reported in the literature. the authors describe a remarkable case of a large lesion leading to bony destruction and spinal cord compression in the cervicothoracic junction with a large intrathoracic extension, which was considered to be a metastatic pulmonary disease but turned out to be actinomycosis. | 2013 | 23670808 |
| effects of aggregatibacter actinomycetemcomitans leukotoxin on endothelial cells. | aggregatibacter actinomycetemcomitans is a human pathogen that produces leukotoxin (ltxa) as a major virulence factor. in this study the effect of ltxa on microvascular endothelial cell viability and phenotype was studied. high doses of single ltxa treatment (500 ng/ml to 5 μg/ml) significantly and irreversibly decreased cell proliferation and induced apoptosis, as assessed by tetrazolium salt and annexin v assay, respectively. apoptosis was partially inhibited by the pan-caspase inhibitor, z-va ... | 2015 | 23665198 |
| soluble triggering receptor expressed on myeloid cells 1 (strem-1) in gingival crevicular fluid: association with clinical and microbiologic parameters. | soluble triggering receptor expressed on myeloid cells 1 (strem-1) belongs to the immunoglobulin superfamily and is involved in amplification of the inflammatory response to bacterial infection. this cross-sectional study aims to investigate the levels of strem-1 in gingival crevicular fluid (gcf) of individuals without periodontitis and with chronic periodontitis (cp) or generalized aggressive periodontitis (gagp) and their association with the levels of key periodontal pathogens in subgingival ... | 2014 | 23659423 |
| salivary carriage of periodontal pathogens in generalized aggressive periodontitis families. | generalized aggressive periodontitis (gap) is a multifactorial disease that shows a specific microbial profile and a familial aggregation. | 2014 | 23647376 |
| detection of eight periodontal microorganisms and distribution of porphyromonas gingivalis fima genotypes in chinese patients with aggressive periodontitis. | the microbiologic feature of aggressive periodontitis (agp) in chinese patients has not yet been determined. this study aims to investigate the prevalence of eight periodontal microorganisms and the distribution of the porphyromonas gingivalis fima genotype in a cohort of chinese patients with agp. | 2014 | 23646850 |
| combining salivary pathogen and serum antibody levels improves their diagnostic ability in detection of periodontitis. | initiation and progression of periodontitis correlates with increased quantities of periodontitis-associated bacteria in periodontal biofilms. in the present study, the aim is to measure aggregatibacter actinomycetemcomitans and porphyromonas gingivalis amounts in saliva and their antibody (immunoglobulin [ig]a and igg) levels in serum and evaluate their diagnostic abilities, together or alone, in chronic periodontitis. | 2014 | 23646849 |
| comparative evaluation of subgingival plaque microflora in pregnant and non-pregnant women: a clinical and microbiologic study. | gingival changes in pregnancy have been attributed to changes in the subgingival biofilm related to hormonal variations. | 2013 | 23633772 |