| azithromycin treatment failure among primary and secondary syphilis patients in shanghai. | azithromycin has been used to treat primary and secondary syphilis and as prophylaxis for sexual partners. we evaluated syphilis treatment failure in patients who received azithromycin therapy. | 2010 | 20644500 |
| examination of periodontal pathogens in stenotic valve specimens and in whole blood samples in patients affected by aortic valve stenosis and chronic periodontitis. | periodontitis may be a risk factor for atherosclerosis and coronary heart disease. the influence of periodontal pathogens in cardiovascular diseases needs further investigation. therefore, the aims of this clinical study are: to test the presence of periodontal bacteria dna in aortic valves and to assess the concomitant presence of the same periodontal bacteria dna in whole blood samples in patients affected by aortic valve stenosis and chronic periodontitis. nineteen consecutive patients (12 ma ... | 2010 | 20646351 |
| secondary yaws: an endemic treponemal infection. | although yaws is rare in developed countries, as worldwide travel has become commonplace, it is essential to recognize this condition when evaluating patients who traveled from endemic regions. herein, we discuss a case of secondary yaws presenting as extensive expanding annular lesions to raise awareness of this condition. | 2010 | 20653853 |
| an immunofiltration device for the simultaneous detection of non-treponemal and treponemal antibodies in patients with syphilis. | the development of a rapid immunofiltration (flow-through) test for the simultaneous detection of non-treponemal and treponemal antibodies in the serum of patients with syphilis. | 2010 | 20656720 |
| 16s rrna-based detection of oral pathogens in coronary atherosclerotic plaque. | atherosclerosis develops as a response of the vessel wall to injury. chronic bacterial infections have been associated with an increased risk for atherosclerosis and coronary artery disease. the ability of oral pathogens to colonize in coronary atheromatous plaque is well known. | 2010 | 20657096 |
| characterization of the normal bacterial flora in peri-implant sulci of partially and completely edentulous patients. | to characterize the normal bacterial flora and evaluate the presence of periodontopathogenic bacteria around dental implants and to correlate them with the periodontal flora or, in completely edentulous patients, the alveolar gingival flora. | 2010 | 20657863 |
| the ability of the bana test to detect different levels of p. gingivalis, t. denticola and t. forsythia. | the aim of this study was to evaluate the ability of the bana test to detect different levels of porphyromonas gingivalis, treponema denticola and tannerella forsythia or their combinations in subgingival samples at the initial diagnosis and after periodontal therapy. periodontal sites with probing depths between 5-7 mm and clinical attachment level between 5-10 mm, from 53 subjects with chronic periodontitis, were sampled in four periods: initial diagnosis (t0), immediately (t1), 45 (t2) and 60 ... | 2010 | 20658043 |
| [association between phenytoin-induced gingival hyperplasia and periodontopathic bacteria in institutionalized patients with severe motor and intellectual disabilities]. | the association between phenytoin-induced gingival hyperplasia (pigh) and five major periodontopathic bacteria was investigated by real-time pcr in 12 subjects (30.6 +/- 7.95 years of age) with severe motor and intellectual disabilities. the subjects had not received antibiotics or periodontal therapy within three months. a healthy gingival site or a site with the lowest gingival hyperplasia score (minimum site), and a site with the maximum score of gingival hyperplasia (maximum site) on each su ... | 2010 | 20662307 |
| a novel quantum dots-based point of care test for syphilis. | one-step lateral flow test is recommended as the first line screening of syphilis for primary healthcare settings in developing countries. however, it generally shows low sensitivity. we describe here the development of a novel fluorescent poc (point of care) test method to be used for screening for syphilis. the method was designed to combine the rapidness of lateral flow test and sensitiveness of fluorescent method. 50 syphilis-positive specimens and 50 healthy specimens conformed by treponema ... | 2010 | 20672123 |
| variability of treponemes in the rumen of ruminants. | complete 16s rrna sequences were determined of recently proposed new species of treponemes designated strain s and t. sequence comparison indicated that both species belong to the treponema saccharophilum cluster, having thus at least 5 cultivable representatives. phylogenetic analysis of available genbank 16s rrna sequences revealed two phylogenetically distant treponema clusters (t. saccharophilum cluster and t. bryantii cluster). surprisingly, while among cultivated treponemes dominate t. sac ... | 2010 | 20680575 |
| td92, an outer membrane protein of treponema denticola, induces osteoclastogenesis via prostaglandin e(2)-mediated rankl/osteoprotegerin regulation. | periodontitis is a chronic inflammatory disease of the periodontium that causes significant alveolar bone loss. osteoclasts are bone-resorbing multinucleated cells. osteoblasts regulate osteoclast differentiation by expression of rankl and osteoprotegerin (opg). td92 is a surface-exposed outer membrane protein of treponema denticola, a periodontopathogen. although it has been demonstrated that td92 acts as a stimulator of various proinflammatory mediators, the role of td92 in alveolar bone resor ... | 2010 | 20682013 |
| novel treponema pallidum serologic tests: a paradigm shift in syphilis screening for the 21st century. | the mainstay of diagnosis for treponema pallidum infections is based on nontreponemal and treponemal serologic tests. many new diagnostic methods for syphilis have been developed, using specific treponemal antigens and novel formats, including rapid point-of-care tests, enzyme immunoassays, and chemiluminescence assays. although most of these newer tests are not yet cleared for use in the united states by the food and drug administration, their performance and ease of automation have promoted th ... | 2010 | 20687840 |
| relationship between oral status and prevalence of periodontopathic bacteria on the tongues of elderly individuals. | colonization of periodontopathic bacteria is associated with increased risk of systemic diseases. however, few studies have investigated the relationships between oral status factors and health-related quality of life (hr-qol) and the prevalence of such bacteria in elderly individuals. this study investigated the prevalence of porphyromonas gingivalis, prevotella intermedia, treponema denticola and tannerella forsythia in 165 community-dwelling functionally independent 85-year-old japanese indiv ... | 2010 | 20688951 |
| a simplified erythromycin resistance cassette for treponema denticola mutagenesis. | the primary selectable marker for the genetic studies of treponema denticola is a hybrid gene cassette containing both ermf and ermam (ermb) genes. ermb functions in escherichia coli, while ermf has been assumed to confer resistance in t. denticola. we demonstrate here that ermb is sufficient for erythromycin selection in t. denticola and that the native ermb promoter drives ermb expression. | 2010 | 20691222 |
| low seroprevalence of syphilis in burkina faso. | little information is available on the epidemiology of syphilis in west africa, where this infection is routinely screened in antenatal clinics to prevent congenital infection. in order to inform control programmes, the burden of active syphilis was estimated among pregnant women and adults in burkina faso. | 2011 | 20693149 |
| oropharyngeal lesions and cervical lymphadenopathy: syphilis is a differential diagnosis that is still relevant. | syphilis (lues), a chronic infectious disease caused by treponema pallidum, has been increasing in incidence during the last few years. therefore, while clinically it is often not suspected, syphilis is increasingly becoming a differential diagnosis in routine pathology. | 2010 | 20702475 |
| the laboratory impact of changing syphilis screening from the rapid-plasma reagin to a treponemal enzyme immunoassay: a case-study from the greater toronto area. | in 2005, syphilis screening in the greater toronto area of canada moved from the rapid plasma reagin (rpr) to a treponemal enzyme immunoassay (eia). we sought to understand the consequences of this change on laboratory results and testing patterns with a population-based retrospective study of laboratory-based diagnoses of syphilis. | 2011 | 20706176 |
| virulence factors of treponema denticola. | | 2010 | 20712637 |
| a solitary skull lesion of syphilitic osteomyelitis. | we experienced a rare case of solitary syphilitic osteomyelitis of the skull without any other clinical signs or symptoms of syphilis. a 20-year-old man was referred due to intermittent headache and mild tenderness at the right parietal area of the skull with a palpable coin-sized lesion of softened cortical bone. on radiological studies, the lesion was a radiolucent well enhanced mass (17 mm in diameter). the erythrocyte sedimentation rate (52 mm/h) and c-reactive protein (2.24 mg/dl) were elev ... | 2010 | 20717520 |
| treponema pallidum. a bibliographical review of the morphology, culture and survival of t. pallidum and associated organisms. | | 1966 | 20718123 |
| antigenic activity of bacterial endodontic contents from primary root canal infection with periapical lesions against macrophage in the release of interleukin-1beta and tumor necrosis factor alpha. | periradicular tissue chronic stimulation by endotoxin may cause apical periodontitis. this study investigated the microbial profile and the levels of endotoxin found in primary root canal infection with apical periodontitis, determined their antigenicity against macrophages through the levels of interleukin (il)-1beta and tumor necrosis factor alpha (tnf-alpha), and evaluated their relationship with clinical and radiographic findings. | 2010 | 20728711 |
| subgingival microbial profiles of smokers with periodontitis. | the subgingival microbiome is largely uncultivated, and therefore, cultivation-based and targeted molecular approaches have limited value in examining the effect of smoking on this community. we tested the hypothesis that the subgingival biofilm is compositionally different in current and never-smokers by using an open-ended molecular approach for bacterial identification. subgingival plaque from deep sites of current and never-smokers matched for disease was analyzed by 16s sequencing. smokers ... | 2010 | 20739702 |
| serologic testing for syphilis in the united states: a cost-effectiveness analysis of two screening algorithms. | the introduction of automated treponemal enzyme immunoassays and chemiluminescence assays (eia/ca) tests has led some laboratories in the united states to use new syphilis screening algorithms that start with a treponemal test. we compared the economic and health outcomes of this new algorithm with the standard algorithm from the perspective of the united states health system. | 2011 | 20739911 |
| origins of syphilis and management in the immunocompetent patient: facts and controversies. | despite the continued efficacy of penicillin since the 1940s, many aspects of the natural history, diagnosis, and management of syphilis remain controversial. a key factor among the numerous factors explaining the persistence of significant areas of controversies is the absence of a gold standard direct method for distinguishing between the different stages of syphilis and appraising treatment response. this contribution presents an overview of some of the most debated aspects of the origins, di ... | 2010 | 20797514 |
| ocular perineuritis secondary to neurosyphilis. | syphilis is a condition caused by the spirochete treponema pallidum (t. pallidum). because of its ubiquitous nature, it has been coined as "the great masquerader." syphilis can present with a wide array of clinical symptoms and manifestations, making it difficult to diagnose. the spectrum of visual system manifestations is broad and involves the anterior and posterior segments. we report a rare case of ocular perineuritis in an hiv-positive patient with neurosyphilis. | 2010 | 20802364 |
| men who have sex with men prefer rapid testing for syphilis and may test more frequently using it. | most australian men who have sex with men who underwent rapid testing for syphilis using the determine syphilis tp immunoassay indicated a preference for rapid testing over conventional serology. most also indicated that they would test for syphilis more frequently if rapid syphilis testing was available in a clinic setting. | 2010 | 20803780 |
| effect of khat chewing on periodontal pathogens in subgingival biofilm from chronic periodontitis patients. | existing in vitro and in vivo data suggest that khat may have a favorable effect on periodontal microbiota. the purpose of this study was to assess the effect of khat chewing on major periodontal pathogens in subgingival plaque samples from subjects with chronic periodontitis. | 2010 | 20816745 |
| case records of the massachusetts general hospital. case 26-2010. a 54-year-old man with loss of vision and a rash. | | 2010 | 20818848 |
| genes for selenium dependent and independent formate dehydrogenase in the gut microbial communities of three lower, wood-feeding termites and a wood-feeding roach. | the bacterial wood-ljungdahl pathway for co(2)-reductive acetogenesis is important for the nutritional mutualism occurring between wood-feeding insects and their hindgut microbiota. a key step in this pathway is the reduction of co(2) to formate, catalysed by the enzyme formate dehydrogenase (fdh). putative selenocysteine- (sec) and cysteine- (cys) containing paralogues of hydrogenase-linked fdh (fdh(h)) have been identified in the termite gut acetogenic spirochete, treponema primitia, but knowl ... | 2011 | 20819103 |
| efficacy and safety of adjunctive local moxifloxacin delivery in the treatment of periodontitis. | moxifloxacin exerts excellent antibacterial activity against most putative periodontal pathogens and has been shown to kill bacteria in biofilm and host cells. | 2011 | 20843236 |
| characterization of treponema pallidum particle agglutination assay-negative sera following screening by treponemal total antibody enzyme immunoassays. | following a laboratory audit, a significant number of treponema pallidum particle agglutination assay (tppa)-negative sera were identified when tppa was used as a confirmatory assay of syphilis enzyme immunoassay (eia) screening-reactive sera (ssrs). sera giving such discrepant results were further characterized to assess their significance. a panel of 226 sera was tested by the abbott murex ice syphilis eia and then by the newmarket syphilis eia ii. tppa testing was performed on 223 sera. furth ... | 2010 | 20844087 |
| development of a colloidal gold-immunochromatography assay to detect immunoglobulin g antibodies to treponema pallidum with tpn17 and tpn47. | syphilis remains a worldwide public health problem; it is necessary to develop a new diagnostic approach that is easier and faster than conventional tests. here, we report a new testing method named colloidal gold-immunochromatography assay (gica) to detect syphilis instead of fluorescent treponemal antibody-absorption (fta-abs). syphilis-specific immunoglobulin g (igg) antibody was detected with gica established on syphilis-specific recombinant proteins, tpn17 and tpn47. fta-abs treponema palli ... | 2010 | 20846810 |
| cellular architecture of treponema pallidum: novel flagellum, periplasmic cone, and cell envelope as revealed by cryo electron tomography. | high-resolution cryo electron tomography (cryo-et) was utilized to visualize treponema pallidum, the causative agent of syphilis, at the molecular level. three-dimensional (3d) reconstructions from 304 infectious organisms revealed unprecedented cellular structures of this unusual member of the spirochetal family. high-resolution cryo-et reconstructions provided detailed structures of the cell envelope, which is significantly different from that of gram-negative bacteria. the 4-nm lipid bilayer ... | 2010 | 20850455 |
| an unusual testicular lump. | a 32-year-old british asian man presented with what appeared clinically and on ultrasound to be a testicular tumour. however, syphilis serology, histology and detection of treponema pallidum dna by polymerase chain reaction confirmed that the lesion was a gumma. without routine syphilis serology, the correct diagnosis may have been missed. | 2010 | 20852208 |
| periodontal parameters and bana test in patents with chronic renal failure undergoing hemodialysis. | the aim of this study was to analyze the periodontal parameters of patients with chronic renal failure. | 2010 | 20857011 |
| patient with aids and acute circinate skin eruptions. | | 2010 | 20858072 |
| il6 -174 genotype associated with aggregatibacter actinomycetemcomitans in indians. | genetic factors have recently been associated with presence of aggregatibacter actinomycetemcomitans subgingivally in populations living in industrialized countries. the aim of this study was to analyse associations between interleukin-6 (il6) single nucleotide polymorphisms and presence and levels of a. actinomycetemcomitans and other subgingival microbes in a rural indian population. | 2011 | 20860759 |
| chronic syphilitic aortic aneurysm complicated with chronic aortic dissection. | historically, tertiary syphilis infection has been the most common cause of thoracic aortic aneurysm, resulting in 5% to 10% of cardiovascular deaths until the era of antibiotics. | 2010 | 20864080 |
| enhanced molecular typing of treponema pallidum: geographical distribution of strain types and association with neurosyphilis. | strain typing is a tool for determining the diversity and epidemiology of infections. | 2010 | 20868271 |
| the usefulness of toluidine red unheated serum test in the diagnosis of hiv-negative neurosyphilis. | we retrospectively analyzed the venereal disease research laboratory test, treponema pallidum particle agglutination test, and toluidine red unheated serum test (trust) in 41 cases of hiv-negative neurosyphilis and 34 non-neurologic syphilitic patient and found that serum-trust titers could be the indication of lumbar puncture in syphilitic patients and a reactive cerebrospinal fluid-trust is considered diagnostic to neurosyphilis. | 2011 | 20871491 |
| [family of ribosomal proteins s1 contains unique conservative domain]. | different representatives of bacteria have different number of amino acid residues in the ribosomal proteins s1. this number varies from 111 (spiroplasma kunkelii) to 863 a.a. (treponema pallidum). traditionally and for lack of this protein three-dimensional structure, its architecture is represented as repeating s1 domains. number of these domains depends on the protein's length. domain's quantity and its boundaries data are contained in the specialized databases, such as smart, pfam and prosit ... | 2010 | 20873233 |
| solitary frontal ulcer: a syphilitic gumma. | we report the case of a 30-year-old woman presenting with a single, deep, asymptomatic frontal ulcer that had developed in the previous two months without preceding trauma. blood tests revealed reactive rapid plasma reagin and treponema pallidum hemagglutination assays. the diagnosis of syphilitic gumma was confirmed after histological analysis of the ulcer border. no other manifestations of late syphilis were detected. ulcer healing was observed after treatment with benzathine penicillin and th ... | 2010 | 20875326 |
| prevalence of bovine papillomavirus and treponema dna in bovine digital dermatitis lesions. | bovine digital dermatitis (bdd) is a common infectious foot disease whose aetiology is not fully understood. its origin is thought to be multifactorial, with treponemes being involved. using pcr-based techniques, bdd samples from 45 affected cows and intact skin from 8 bdd-affected and 33 healthy cows were assessed for the presence of bovine papillomavirus and treponema dna. bpv dna (mainly bpv-1/2) was detected in 22% of lesions and one skin sample from affected animals, and in 15% (bpv-1/-2) a ... | 2010 | 20875931 |
| surface immunolabeling and consensus computational framework to identify candidate rare outer membrane proteins of treponema pallidum. | treponema pallidum reacts poorly with the antibodies present in rabbit and human syphilitic sera, a property attributed to the paucity of proteins in its outer membrane. to better understand the basis for the syphilis spirochete's "stealth pathogenicity," we used a dual-label, 3-step amplified assay in which treponemes encapsulated in gel microdroplets were probed with syphilitic sera in parallel with anti-flaa antibodies. a small (approximately 5 to 10%) but reproducible fraction of intact trep ... | 2010 | 20876295 |
| time trends of syphilis and hsv-2 co-infection among men who have sex with men in the german hiv-1 seroconverter cohort from 1996-2007. | numbers of newly diagnosed hiv infections among men who have sex with men (msm) in germany increased after the year 2000. we sought to explore trends in sti co-infections around the time of hiv seroconversion in patients from the german hiv-1 seroconverter cohort from 1996-2007. | 2010 | 20876750 |
| trichomonas vaginalis-an indicator for other sexually transmitted infecting agents. | the present study is based on 350 women having sexually transmitted diseases (std) and 68 male counterparts. trichomonas vaginalis was a significant contributor in 216 (61.7%) out of 350 female std cases and 56 (82.3%) out of 68 male counterparts. further, out of 126 (58.3%) out of 216 cases of t. vaginalis, 41 cases (32.5%) were associated with candida species; 29 cases (23%) were associated with neisseria gonorrhoeae (n gonorrhoeae); haemophilus ducreyi (h. ducreyi) 18 cases (14.3%) and chlamy ... | 2000 | 20877088 |
| investigation of subgingival profile of periodontopathic bacteria using polymerase chain reaction. | periodontopathic bacteria such as porphyromonas gingivalis, aggregatibacter actinomycetemcomitans, tannerella forsythia, campylobacter rectus and treponema denticola play an important role in the initiation and progression of periodontitis. the aim of this investigation was to evaluate the relationship between periodontal clinical parameters and the subgingival profile of periodontopathic bacteria. twenty-six periodontitis patients (23-62 years of age; mean age, 40.2±13.2) with no systemic disea ... | 2010 | 20877160 |
| novel point-of-care test for simultaneous detection of nontreponemal and treponemal antibodies in patients with syphilis. | we describe a point-of-care immunochromatographic test for the simultaneous detection of both nontreponemal and treponemal antibodies in the sera of patients with syphilis that acts as both a screening and a confirmatory test. a total of 1,601 banked serum samples were examined by the dual test, and the results were compared to those obtained using a quantitative rapid plasma reagin (rpr) test and the treponema pallidum passive particle agglutination (tp-pa) assay. compared to the rpr test, the ... | 2010 | 20881177 |
| host defense mechanisms in secondary syphilitic lesions: a role for ifn-gamma-/il-17-producing cd8+ t cells? | cell-mediated immunity is thought to be of critical importance in antisyphilitic host defense, but the exact mechanisms are still unknown. this fact is particularly true for hiv-infected persons with a deficit in cd4+ t-cell number. we therefore obtained lesional skin samples from hiv+ and hiv- patients with secondary syphilis at different time points of lesional age to search both for causative microorganisms and to characterize the inflammatory infiltrate. by doing so, we detected treponema pa ... | 2010 | 20889558 |
| demonstration by the ultra-microscope of living treponema pallidum and various spirochætes. | | 1910 | 20898541 |
| on some of the recent advances in the field of microbiology; with demonstrations of the pure cultures of various spirochætes, of the viruses of rabies and poliomyelitis, and of treponema pallidum in the brains of general paralytics. | | 1914 | 20902174 |
| trichomonas vaginalis - an indicator for other sexually transmitted infecting agents. | the present study is based on 350 women having sexually transmitted diseases and 68 men counterparts. trichomonas vaginalis was a significant contributor in 216 (61.7%) out of 350 female sid cases' and in 56 (82.3%) out of 68 male counterparts. further, out of 216 cases of t.vaginalis, 41 cases (32.5%) were associated with infection with candida species; 29 (23%) with neisseria gonorrhoea. 18 cases (14.3%) with haemophilus ducreyi and 11 cases (8.7%), chlamydia trachomatis. treponema pallidum wa ... | 1998 | 20921795 |
| surveying infections among pregnant women in the niger delta, nigeria. | there is paucity of epidemiological data on infectious diseases among antenatal mothers in bayelsa state of the niger delta, nigeria. | 2010 | 20927278 |
| virulence factors of the oral spirochete treponema denticola. | there is compelling evidence that treponemes are involved in the etiology of several chronic diseases, including chronic periodontitis as well as other forms of periodontal disease. there are interesting parallels with other chronic diseases caused by treponemes that may indicate similar virulence characteristics. chronic periodontitis is a polymicrobial disease, and recent animal studies indicate that co-infection of treponema denticola with other periodontal pathogens can enhance alveolar bone ... | 2010 | 20940357 |
| [serologic test for syphilis (sts, fta-abs, igm-fta-abs, and tpha)]. | | 2010 | 20942023 |
| treponema species detected in infected root canals and acute apical abscess exudates. | different microbial communities have been associated with acute endodontic infections. the majority of the microorganisms are as yet uncultivable or difficult to grow under current laboratory conditions. treponema species are strict anaerobic bacteria that are involved in several oral diseases. the aim of this study was to detect the presence of treponema species in infected root canals (rcs) and exudates related to acute apical abscesses (aaas) as well as to determine positive association betwe ... | 2010 | 20951290 |
| [primary syphilis with initial lower-lip sclerosis--a case report]. | we report a case of primary syphilis with initial lower-lip sclerosis. 54-year-old man seen for a left lower-lip lesion was found in serological testing to have elevated syphilis-rapid plasma regain (sts-rpr) and treponema pallidum lipid antigen (tpla), diagnosed as primary syphilis. following four weeks of 1500 mg/day amoxicillin administration, the lesion had almost disappeared. serological data had improved to within the negative range six months after antibiotic treatment started. this case ... | 2010 | 20954363 |
| real-time polymerase chain reaction of "red complex" (porphyromonas gingivalis, tannerella forsythia, and treponema denticola) in periradicular abscesses. | the red complex bacteria (porphyromonas gingivalis, tannerella forsythia, and treponema denticola) have been implicated, either singly or in combination, in the development of various forms of periodontal diseases. the aim of this study was to investigate the presence of "red complex" in acute periradicular abscesses by real-time polymerase chain reaction (pcr) method. | 2010 | 20955954 |
| [serological markers in immigrant and spanish pregnant women in granada]. | female immigration from less developed countries into spain has grown in number over the years, and could contribute to changing the prevalence of routine serological markers in pregnant women. | 2010 | 20961669 |
| secondary syphilis resembling erythema multiforme. | secondary syphilis, which typically begins 4-10 weeks after initial exposure to treponema pallidum, manifests with a range of cutaneous patterns. one unusual variation features oval, targetoid plaques that may resemble erythema multiforme (em). | 2010 | 20964658 |
| penicillin sensitivity and morphology of the reiter strain of treponema pallidum after cultivation in media containing penicillin. | | 1946 | 20984454 |
| agglutination studies of the smaller oral treponemata, borrelia vincentii and cultured strains of treponema pallidum. | | 1946 | 20988357 |
| what rôle do treponema vincenti play in certain diseases of the gingiva? | | 1946 | 20989512 |
| preservation of virulence of treponema pallidum; some additional laboratory methods. | | 1946 | 20992502 |
| isolation of virulent treponema pallidum from human aorta thirty-two hours after death from cardiovascular syphilis. | | 1946 | 20996102 |
| action of penicillin, especially on treponema pallidum. | | 1946 | 21016274 |
| development of an innovative serological test for detection of antibodies to treponema pallidum. | | 2010 | 21034254 |
| hemagglutinin/adhesin domains of porphyromonas gingivalis play key roles in coaggregation with treponema denticola. | porphyromonas gingivalis and treponema denticola are major pathogens of periodontal disease. coaggregation between microorganisms plays a key role in the colonization of the gingival crevice and the organization of periodontopathic biofilms. we investigated the involvement of surface ligands of p. gingivalis in coaggregation. two triple mutants of p. gingivalis lacking arg-gingipain a (rgpa), lys-gingipain (kgp) and hemagglutinin a (haga) or rgpa, arg-gingipain b (rgpb) and kgp showed significan ... | 2010 | 21039921 |
| characterization of a novel family of fibronectin-binding proteins with m23 peptidase domains from treponema denticola. | interactions with fibronectin are important in the virulence strategies of a range of disease-related bacteria. the periodontitis-associated oral spirochaete treponema denticola expresses at least two fibronectin-binding proteins, designated msp (major surface protein) and oppa (oligopeptide-binding protein homologue). to identify other t. denticola outer membrane fibronectin-binding proteins, the amino acid sequence of the treponema pallidum fibronectin-binding protein tp0155 was used to survey ... | 2010 | 21040511 |
| infection status and risk factors of hiv, hbv, hcv, and syphilis among drug users in guangdong, china--a cross-sectional study. | china has witnessed a remarkable increase in sexually transmitted infections (stis) and hiv. the study is to assess the prevalence of hiv, hbv, hcv and syphilis and related risk factors among drug users in mandatory detoxification center qingyuan, guangdong, china. | 2010 | 21040549 |
| transcriptional profiles of treponema denticola in response to environmental conditions. | the periodontal pathogen t. denticola resides in a stressful environment rife with challenges, the human oral cavity. knowledge of the stress response capabilities of this invasive spirochete is currently very limited. whole genome expression profiles in response to different suspected stresses including heat shock, osmotic downshift, oxygen and blood exposure were examined. most of the genes predicted to encode conserved heat shock proteins (hsps) were found to be induced under heat and oxygen ... | 2010 | 21048920 |
| early bacterial colonization and soft tissue health around zirconia and titanium abutments: an in vivo study in man. | aim: to compare the early bacterial colonization and soft tissue health of mucosa adjacent to zirconia (zro(2) ) and titanium (ti) abutment surfaces in vivo. materials and methods: twenty edentulous subjects received two endosseous mandibular implants. the implants were fitted with either a zro(2) or a ti abutment (non-submerged implant placement, within-subject comparison, left-right randomization). sulcular bacterial sampling and the assessment of probing pocket depth, recession and bleeding o ... | 2010 | 21054554 |
| characterization of novel bovine gastrointestinal tract treponema isolates and comparison with bovine digital dermatitis treponemes. | this study aimed to isolate and characterize treponemes present in the bovine gastrointestinal (gi) tract and compare them with bovine digital dermatitis (bdd) treponemes. seven spirochete isolates were obtained from the bovine gi tract, which, on the basis of 16s rrna gene comparisons, clustered within the genus treponema as four novel phylotypes. one phylotype was isolated from several different gi tract regions, including the omasum, colon, rumen, and rectum. these four phylotypes could be di ... | 2010 | 21057019 |
| erythema multiforme-like secondary syphilis in a hiv-positive bisexual man. | | 2010 | 21057757 |
| studies on the biologic relationship between the causative agents of syphilis, yaws, and venereal spirochetosis of rabbits; observations on treponema cun iculi infection in rabbits. | | 1946 | 21065218 |
| targeting selenium metabolism and selenoproteins: novel avenues for drug discovery. | selenoproteins play a wide range of roles in metabolism and oxidative stress defense and are produced by organisms in all three domains of life. recent evidence has been presented that metal based cancer drugs target the selenol nucleophile of the active site selenocysteine in thioredoxin reductase isoenzymes. other metals and metalloids, such as tin, arsenic and gold, have also recently been shown to form stable complexes with hydrogen selenide, a required precursor for the synthesis of selenop ... | 2010 | 21069141 |
| the effect of a single episode of antimicrobial photodynamic therapy in the treatment of experimental periodontitis. microbiological profile and cytokine pattern in the dog mandible. | the purpose of this study was to evaluate the effect of a single application of antimicrobial photodynamic therapy (apdt) on microbiological profile and cytokine pattern in dogs. periodontal disease was induced by placing 3.0 silk ligatures around the mandibular pre-molars bilaterally during 8 weeks. the dogs were randomly treated with apdt using a dye/laser system, scaling and root planning (srp), or with the association of treatments (srp + apdt). plaque samples were collected at baseline, 1, ... | 2010 | 21086009 |
| one-stage full-mouth disinfection as a therapeutic approach for generalized aggressive periodontitis. | background: data concerning treatment outcomes in patients with generalized aggressive periodontitis (gagp) are limited. the aim of this study is to investigate 6-month clinical and microbiologic outcomes of the one-stage full-mouth disinfection (osfmd) in the management of patients with gagp. methods: twenty-seven patients with advanced gagp were included in this prospective follow-up intervention study. clinical and microbiologic parameters were collected at baseline and 3 and 6 months after t ... | 2010 | 21091345 |
| seroprevalence of syphilis in apparently healthy students from a tertiary institution in benin city, nigeria. | the seroprevalence of syphilis in students from a tertiary institution in benin city, nigeria was investigated. venous blood samples (5 ml) were collected from 214 apparently healthy students aged 19-38 years (118 males and 96 females) between february and october 2009 and the serostatus of syphilis determined qualitatively using the rapid plasma reagin test. seropositive sera were confirmed using the treponema pallidum hemagglutination test. the total seropositivity for syphilis was 15.4%, with ... | 2010 | 21099096 |
| vesiculobullous syphilis: a case involving an unusual cutaneous manifestation of secondary syphilis. | the recent resurgence of syphilis mandates that clinicians maintain a heightened suspicion for treponema infection, and that they be aware of the variety of cutaneous presentations that may mimic eczema, psoriasis, drug eruption, erythema multiforme, lichen planus, tinea versicolor, seborrheic dermatitis, mycosis fungoides, or other lichenoid lesions. in this report, we describe an unusual case of secondary syphilis in an adult woman, and briefly review the wide array of syphilitic dermopathy th ... | 2010 | 21106408 |
| periodontal pathogens interfere with quorum-sensing-dependent virulence properties in streptococcus mutans. | the mechanism by which periodontal pathogens dominate at disease sites is not yet understood. one possibility is that these late colonizers antagonize the quorum-sensing systems of early colonizers and render those early colonizers less resistant to environmental factors. in this study, we utilized streptococcus mutans, a well-documented oral streptococcus with many quorum-sensing-dependent properties, as an example of an earlier colonizer antagonized by periodontal pathogens. | 2010 | 21108642 |
| the treponema denticola chymotrypsin-like protease dentilisin induces matrix metalloproteinase-2-dependent fibronectin fragmentation in periodontal ligament cells. | periodontal disease is a bacterially mediated chronic inflammatory disease that results in destruction of the periodontal ligament (pdl) and alveolar bone that surround and support the dentition. while their precise roles are not well understood, periodontal pathogens, including treponema denticola, are believed to initiate the destructive inflammatory responses and dysregulation of tissue homeostasis that characterize the disease. these responses are believed to result from both proinflammatory ... | 2010 | 21115719 |
| stroke in a patient with human immunodeficiency virus and syphilis treated with penicillin and antiretroviral therapy. | with the rising incidence and prevalence of syphilis, meningovascular syphilis and other forms of neurosyphilis have reappeared, particularly among persons infected with human immunodeficiency virus. we present a patient with meningovascular syphilis leading to stroke after treatment with penicillin and antiretroviral therapy. | 2010 | 21124258 |
| congenital syphilis: early- and late-stage findings of rhagades and dental anomalies. | congenital syphilis occurs via vertical transmission when treponema pallidum crosses the placenta after the 16th week of gestation. manifestations of congenital syphilis vary from asymptomatic infection to stillbirth. we present a case of congenital syphilis in a vietnamese orphan who presented with rhagades, hearing deficit, and abnormal dentition after adoption in the united states. he demonstrated both early- and late-stage findings of congenital syphilis. he is presumed to be 5 years old, an ... | 2010 | 21133996 |
| bacterial and viral pathogens in saliva: disease relationship and infectious risk. | | 2011 | 21134228 |
| serum cytokine levels in periodontitis patients in relation to the bacterial load. | background: periodontitis is a local inflammatory disease that also has some systemic effects. we investigated the levels of interferon (ifn)-γ, tumor necrosis factor (tnf)-α, and interleukin (il)-2, -4, -5, and -10 in the serum of patients with periodontitis in relation to the bacterial load in the dental plaques. methods: serum cytokine levels in patients with generalized periodontitis and healthy control groups were determined using the cytometric bead array kit. bacterial load in the dental ... | 2010 | 21138356 |
| the central region of the msp gene of treponema denticola has sequence heterogeneity among clinical samples, obtained from patients with periodontitis. | treponema denticola is an oral spirochete involved in the pathogenesis and progression of periodontal disease. of its virulence factors, the major surface protein (msp) plays a role in the interaction between the treponeme and host. to understand the possible evolution of this protein, we analyzed the sequence of the msp gene in 17 t. denticola positive clinical samples. | 2010 | 21138575 |
| prevalence and risk factors for sexually transmitted infections in a high-risk occupational group: the case of fishermen along lake victoria in kisumu, kenya. | the aim of this study was to assess prevalence and risk factors for sexually transmitted infections (stis) among fishermen along lake victoria, kenya. this cross-sectional study surveyed 250 fishermen from beaches in kisumu district using proportional-to-size sampling based on the number of registered boats per beach. participants provided demographic and sexual behaviour information, blood for hiv-1 herpes simplex virus type 2 (hsv-2) and syphilis serological tests urine for transcription-media ... | 2010 | 21139150 |
| trends in the prevalence of transfusion-transmissible infections among blood donors in albania. | the objective of this study is to determine the trend of transfusion transmitted infection in blood donors. | 2010 | 21141446 |
| comparison of real-time polymerase chain reaction and dna-strip technology in microbiological evaluation of periodontitis treatment. | the impact of a semiquantitative commercially available test based on dna-strip technology (microident®, hain lifescience, nehren, germany) on diagnosis and treatment of severe chronic periodontitis of 25 periodontitis patients was evaluated in comparison with a quantitative in-house real-time pcr. subgingival plaque samples were collected at baseline as well as at 3, 6, and 12 months later. after extracting dna, aggregatibacter actinomycetemcomitans, porphyromonas gingivalis, tannerella forsyth ... | 2011 | 21146709 |
| bifunctional role of the treponema pallidum extracellular matrix binding adhesin tp0751. | treponema pallidum, the causative agent of syphilis, is a highly invasive pathogenic spirochete capable of attaching to host cells, invading the tissue barrier, and undergoing rapid widespread dissemination via the circulatory system. the t. pallidum adhesin tp0751 was previously shown to bind laminin, the most abundant component of the basement membrane, suggesting a role for this adhesin in host tissue colonization and bacterial dissemination. we hypothesized that similar to that of other inva ... | 2010 | 21149586 |
| sexually transmitted diseases treatment guidelines, 2010. | these guidelines for the treatment of persons who have or are at risk for sexually transmitted diseases (stds) were updated by cdc after consultation with a group of professionals knowledgeable in the field of stds who met in atlanta on april 18-30, 2009. the information in this report updates the 2006 guidelines for treatment of sexually transmitted diseases (mmwr 2006;55[no. rr-11]). included in these updated guidelines is new information regarding 1) the expanded diagnostic evaluation for cer ... | 2010 | 21160459 |
| [detection of putative periodontal pathogens of periodontitis with type 2 diabetes]. | to detect the putative periodontal pathogens in the subgingival plaque of chronic periodontitis (cp) patients with type 2 diabetes mellitus (dm) and to discuss the role of the periodontal pathogens in the cp and type 2 dm patients. | 2010 | 21163008 |
| a 'clap' for in silico studies. | | 2011 | 21164533 |
| introduction of rapid tests for large-scale syphilis screening among female, male, and transgender sex workers in mumbai, india. | despite widespread availability of rapid plasma reagin (rpr) for syphilis screening at sex worker (sw)-dedicated project clinics, uptake of syphilis testing remains low and prevalence of syphilis remains high among sws in maharashtra, india. the primary reasons given for refusal of rpr were fear of venipuncture and long waiting times for results. | 2011 | 21183861 |
| the tale of two serologic tests to screen for syphilis-treponemal and nontreponemal: does the order matter? | background:: standard syphilis screening involves an initial screening with a nontreponemal test and confirmation of positives with a treponemal test. however, some laboratories have reversed the order. there is no detailed quantitative and qualitative evaluation for the order of testing. in this study, we analyzed the health and economic outcomes of the order of testing for the 2 serologic tests used in syphilis screening under pure screening settings. methods:: we used a cohort decision analys ... | 2010 | 21183862 |
| preliminary assessment of treponema pallidum-specific igm antibody detection and a new rapid point-of-care assay for the diagnosis of syphilis in human immunodeficiency virus-1-infected patients. | the aims of the study were to assess whether treponema pallidum-specific igm may provide a useful marker of infectious syphilis in human immunodeficiency virus (hiv)-infected patients, and to compare the performance of a prototype igm-rapid point-of-care test (poct) with a standard igm-enzyme immunoassay (eia). twenty samples from hiv-infected patients with untreated syphilis (n = 4 primary syphilis, n = 11 secondary and n = 5 early latent) and 51 follow-up samples at three, six or 12 months aft ... | 2010 | 21187358 |
| phylogenetic diversity and dietary association of rumen treponema revealed using group-specific 16s rrna gene-based analysis. | treponema spp. are a commonly detected bacterial group in the rumen that are involved in the degradation of soluble fibers. in this study, a ruminal treponema group-specific pcr primer targeting the 16s rrna gene was designed and used to assess the phylogenetic diversity and diet association of this group in sheep rumen. total dna was extracted from rumen digesta of three sheep fed a diet based on alfalfa/orchardgrass hay or concentrate. the real-time pcr quantification indicated that the relati ... | 2011 | 21204927 |
| use of quantitative pcr to evaluate methods of bacteria sampling in periodontal patients. | periodontal disease is associated with specific periodontal pathogens and may persist as gingivitis or progress to more severe disease. the bacteria involved in disease initiation and progression have not been identified. we used quantitative polymerase chain reaction (pcr) to compare the levels of porphyromonas gingivalis, tannerella forsythia, and treponema denticola, and total bacteria detected by different sampling methods. on the basis of the results of clinical examinations, 57 patients we ... | 2010 | 21206165 |
| effect of smoking on subgingival microflora of patients with periodontitis in japan. | smoking is a risk factor for periodontitis. to clarify the contribution of smoking to periodontitis, it is essential to assess the relationship between smoking and the subgingival microflora. the aim of this study was to gain an insight into the influence of smoking on the microflora of japanese patients with periodontitis. | 2011 | 21208407 |