| expanding the clinical and genetic spectrum of human cd40l deficiency: the occurrence of paracoccidioidomycosis and other unusual infections in brazilian patients. | cd40 ligand (cd40l) deficiency or x-linked hyper-igm syndrome (x-higm) is a well-described primary immunodeficiency in which pneumocystis jiroveci pneumonia is a common clinical feature. we have identified an unusual high incidence of fungal infections and other not yet described infections in a cohort of 11 x-higm patients from nine unrelated brazilian families. among these, we describe the first case of paracoccidioidomycosis (pcm) in x-higm. the molecular genetic analysis of cd40l was perform ... | 2011 | 22193914 |
| proof-of-principle evaluation of the efficacy of fewer than three doses of a bivalent hpv16/18 vaccine. | three-dose regimens for human papillomavirus (hpv) vaccines are expensive and difficult to complete, especially in settings where the need for cervical cancer prevention is greatest. | 2011 | 21908768 |
| evidence for alteration of ezh2, bmi1, and kdm6a and epigenetic reprogramming in human papillomavirus type 16 e6/e7-expressing keratinocytes. | a number of epigenetic alterations occur in both the virus and host cellular genomes during human papillomavirus (hpv)-associated carcinogenesis, and investigations of such alterations, including changes in chromatin proteins and histone modifications, have the potential to lead to therapeutic epigenetic reversion. we report here that transformed hpv16 e6/e7-expressing primary human foreskin keratinocytes (hfks) (e6/e7 cells) demonstrate increased expression of the prc2 methyltransferase ezh2 at ... | 2011 | 21865393 |
| [human papilloma virus and lymphatic metastasis in squamous cell carcinoma of the cervix]. | our study included 112 patients with squamous cell cervical carcinoma la-lib stages (figo). all of them were restaged on the basis of histological evidence after surgical treatment. ninety-eight were staged at final analysis. human papilloma virus (hpv) was detected in endocervical smears and paraffin blocks of lymph nodes by pcr and real-time pcr. oncogenic hpv in primary tumor was detected in 86 (87.8%); two or more genotypes--65 (75.58%): still more--21 (24.4%). in the latter group, the frequ ... | 2011 | 21882602 |
| intracervical procedures and the risk of subsequent very preterm birth: a case-control study. | objective. to investigate the relation of prior intracervical procedures with very preterm birth. design. a population-based case-control study. setting. the study was conducted in australia between 2002 and 2004. sample. 345 women having a medically indicated and 236 having a spontaneous singleton birth between 20 and 31 weeks of gestation and 796 women selected randomly from all giving birth at 37 or more weeks of gestation. methods. interview data were analysed using logistic regression. outc ... | 2011 | 22085381 |
| efficacy of a bivalent hpv 16/18 vaccine against anal hpv 16/18 infection among young women: a nested analysis within the costa rica vaccine trial. | anal cancer remains rare (incidence of about 1·5 per 100,000 women yearly), but rates are increasing in many countries. human papillomavirus (hpv) 16 and 18 infections cause most cases of anal cancer. we assessed efficacy of an as04-adjuvanted hpv 16 and hpv 18 vaccine against anal infection with hpv 16, hpv 18, or both (hpv 16/18). | 2011 | 21865087 |
| molecular changes in the multistage pathogenesis of head and neck cancer. | head and neck squamous cell carcinomas (scchn) arise in the mucosa of the upper aerodigestive tract at multiple anatomic sites. while tobacco and alcohol exposure remain the primary risk factors for this malignancy, infection with the human papilloma virus is emerging as a major contributing factor to cancers that arise primarily in the oropharynx. despite therapeutic advances, survival has remained relatively unchanged over the past few decades. increased understand of the cellular and molecula ... | 2011 | 22112483 |
| extraction, purification and characterization of the plant-produced hpv16 subunit vaccine candidate e7 ggg. | several studies indicated that biopharmaceuticals based on the recombinant protein e7 of human papillomavirus (hpv) can serve as therapeutic vaccines preventing the development of cancer in women infected with high-risk types of hpv such as hpv16. here, we report effective extraction and purification of a plant-produced e7ggg-lichenase fusion protein, an hpv16 subunit vaccine candidate, from nicotiana benthamiana plants, to a high yield. the target contains the modified hpv16 e7 protein internal ... | 2012 | 22134037 |
| sexually transmitted diseases in men who have sex with men. | men who have sex with men (msm) have increased rates of human immunodeficiency virus (hiv) infection and sexually transmitted diseases (stds) compared with demographically matched controls. the reasons for the disproportionate infection burden are complex, including biological, behavioral, and sociocultural factors. hiv and syphilis may often be coprevalent among msm. the use of nucleic acid amplification testing has enhanced the ability to detect frequently asymptomatic gonococcal and chlamydia ... | 2011 | 22080272 |
| reproductive tract infections in hiv positive women: a case control study. | human immunodeficiency virus (hiv) infection primarily affects women during their reproductive years, and the coexistence of reproductive tract infections (rtis) is not surprising given the fact that hiv is mainly acquired via heterosexual contact. | 2009 | 21938108 |
| Prevalence and Distribution of High-Risk Genotypes of HPV in Women with Severe Cervical Lesions in Madrid, Spain: Importance of Detecting Genotype 16 and Other High-Risk Genotypes. | Background. Persistent infection with high-risk human papillomavirus (HR-HPV) has been demonstrated to be the necessary causal factor for developing cervical cancer. To know the most prevalent HR-HPV in different geographical areas is important to design diagnostic tests and implementation of vaccines. Objectives. The goal of this study is to evaluate the prevalence of HR-HPV in a total of 1001 patients, 198 with normal cytology results, 498 with low-grade squamous intraepithelial lesion (LSIL), ... | 2011 | 21991433 |
| cervical cytology and histopathologic abnormalities in women living with aids in são paulo, brazil. | women living with hiv/aids present with a higher prevalence of human papillomavirus (hpv) infection, higher rates of squamous intraepithelial lesions, and are more susceptible to invasive cervical carcinoma progression. | 2011 | 21857321 |
| Integration of human papillomavirus 18 DNA in esophageal carcinoma 109 cells. | To detect human papillomavirus (HPV) DNA in esophageal carcinoma (EC) 109 cells and investigate the relationship between HPV and EC. | 2011 | 22072858 |
| management strategies and cost effectiveness in the prevention of cervical cancer. | this paper introduces the burden of cervical cancer and the primary and secondary preventative interventions currently available, and provides an overview of the bivalent and quadrivalent human papillomavirus (hpv) vaccines. a brief account of the virology and the clinical efficacy of both is given. examinations of the two main types of cost analyses, cost-effective and cost-benefit, as well as examples, are presented in addition to the possible impact these analyses and further economic models ... | 2009 | 21935303 |
| survey of national immunization programs and vaccine coverage rates in asia pacific countries. | children in the asia pacific region are still suffering from certain vaccine-preventable diseases. the current study surveyed the national immunization programs and vaccine uptake of traditional and newly developed vaccines in 12 countries in this area. the results showed children in most countries were well protected from conventional vaccine-preventable diseases, while immunization programs for certain diseases such as poliovirus or measles should be strengthened in certain countries. protecti ... | 2011 | 22075085 |
| the e6 oncoprotein from hpv16 enhances the canonical wnt/β-catenin pathway in skin epidermis in vivo. | the contribution of the wnt signaling pathway to hpv-induced carcinogenesis is poorly understood. in high-grade dysplastic lesions that are caused by high-risk human papilloma viruses (hr-hpvs), β-catenin is often located in the cell nucleus, which suggests that wnt pathway may be involved in the development of hpv-related carcinomas. most of the oncogenic potential of hr-hpvs resides on the e6 protein's pdz-binding domain. we hypothesized that the pdz-binding domain of the hpv16-e6 oncoprotein ... | 2011 | 22160870 |
| Comparison of the cobas Human Papillomavirus (HPV) Test with the Hybrid Capture 2 and Linear Array HPV DNA Tests. | The cobas human papillomavirus (HPV) test (cobas) was recently approved by the U.S. Food and Drug Administration (FDA) and identifies HPV16 and HPV18 separately as well as detecting a pool of 11 HR-HPV genotypes (HPV31, -33, -35, -39, -45, -51, -52, -56, -58, -59, -68) and also HPV66. We compared cobas, Linear Array (LA), and Hybrid Capture 2 (HC2) assays for detection of carcinogenic HPV DNA, and cobas and LA for detection of HPV16 and HPV18 DNA, among the first 1,852 women enrolled in the HPV ... | 2012 | 22075592 |
| human papillomavirus detection by pcr assay in a large series of high-grade squamous intraepithelial lesions with cytohistological correlation and follow-up. | high-grade squamous intraepithelial lesions (hsil) are the precursors of invasive cervical carcinomas and are generally associated with the integration of mucosotropic human papillomavirus (hpv) dna into the host cell genome. detection of hpv is easy to perform nowadays, even in laboratories with limited technological capacity, and follow-up procedures for patients with hsil are well established. | 2011 | 21986169 |
| Evaluation of any or type-specific persistence of high-risk human papillomavirus for detecting cervical precancer. | Background:High-risk human papillomavirus (HR-HPV) testing is increasingly important; we examined the impact on accuracy of repeated vs. one-time testing, type-specific vs. pooled detection, and assay analytic sensitivity.Methods:Using a nested case-control design from the ASCUS-LSIL Triage Study, we selected women with incident cervical intraepithelial neoplasia grade 2 or grade 3 (CIN2/3, n = 325) and a random sample of women with <CIN2 as controls (n = 401). HPV DNA status was assessed using ... | 2011 | 22162556 |
| distribution of human papillomavirus genotypes in archival cervical tissue from women with cervical cancer in urban sri lanka. | to identify the contributions of various human papillomavirus (hpv) genotypes in tissue samples from women diagnosed with cervical cancer in sri lanka. | 2011 | 21872246 |
| what women want. women's preferences for the management of low-grade abnormal cervical screening tests: a systematic review. | if human papillomavirus (hpv) testing will replace cytology in primary cervical screening, the frequency of low-grade abnormal screening tests will double. several available alternatives for the follow-up of low-grade abnormal screening tests have similar outcomes. in this situation, women's preferences have been proposed as a guide for management decisions. | 2012 | 21895959 |
| Perianal giant condyloma acuminata in an infant: an alarming lesion for a pediatric surgeon. | Condyloma acuminatum (CA), which is a large cauliflower-like tumor, has been linked to human papilloma virus (HPV) types associated with skin warts. It is an uncommon condition in children, and there is no consensus regarding the optimal treatment. HPV may be acquired via sexual transmission, vertical transmission or extragenital contact. We report herein a 1.5-year-old girl with perianal giant CA, which developed due to extragenital contact and consisted of HPV types 6 and 18, to emphasize the ... | 2011 | 21980819 |
| HPV in exhaled breath condensate of lung cancer patients. | A recent intriguing carcinogenetic hypothesis for lung cancer foresees its viral aetiology. The human papilloma virus (HPV) is the main virus actually recognised in the pathogenesis of lung cancer. The aim of this study was to investigate, for the first time to our knowledge, the presence of HPV in the exhaled breath condensate (EBC) of lung cancer patients. | 2011 | 21952627 |
| Streptococci-Human Papilloma Virus Interaction With Ethanol Exposure Leads to Keratinocyte Damage. | PURPOSE: Ethanol, human papilloma virus (HPV), and poor oral hygiene are risk factors that have been attributed to oral carcinogenesis. Streptococci sp and HPV infections are common in the head and neck, often associated with sexual activity. Although HPV is linked to head and neck squamous cell carcinoma, it is unclear whether there is a similar role for Streptococci sp. This cell study examines whether Streptococci sp and HPV-16 with exposure to ethyl alcohol (ETOH) can act as cofactors in the ... | 2011 | 22079067 |
| comparison of the cobas 4800 human papillomavirus test against a combination of the amplicor human papillomavirus and the linear array tests for detection of hpv types 16 and 18 in cervical samples. | the greater prevalence of human papillomavirus (hpv) types 16 and 18 compared to the other high-risk hpv types of cervical cancer led to the development of clinical tests that detect both types separately from other genotypes. one method is the roche cobas 4800 hpv test, which is based on a real-time pcr. the aim of this study was to evaluate the performance of the cobas 4800 hpv test for detecting genotypes 16 and 18 by comparing the results with those obtained in a combination of the roche amp ... | 2011 | 22197189 |
| the clinical meaning of a cervical intraepithelial neoplasia grade 1 biopsy. | to determine whether the diagnosis of cervical intraepithelial neoplasia (cin) grade 1 increases the risk of cin 3 above what is observed for human papillomavirus (hpv) infection. | 2011 | 22105250 |
| prevalence of abnormalities influences cytologists' error rates in screening for cervical cancer. | medical screening tasks are often difficult, visual searches with low target prevalence (low rates of disease). under laboratory conditions, when targets are rare, nonexpert searchers show decreases in false-positive results and increases in false-negative results compared with results when targets are common. this prevalence effect is not due to vigilance failures or target unfamiliarity. | 2011 | 22129183 |
| prevalence and risk factors of hpv infection among women from various provinces of the world. | objective: we set to estimate the genotype-specific prevalence of human papilloma virus (hpv) and its associated risk factors responsible among women with normal and abnormal cytology by systematic literature survey. methods: reports on hpv prevalence published between 2000 and 2011 were retrieved. to be included, studies required information on cervical cytology, plus detailed descriptions of study populations, ... | 2011 | 22159694 |
| Longitudinal Analysis of Carcinogenic Human Papillomavirus Infection and Associated Cytologic Abnormalities in the Guanacaste Natural History Study: Looking Ahead to Cotesting. | Background. Few studies have addressed the timing of cervical cytologic abnormalities and human papillomavirus (HPV) positivity during the course of an infection. It remains largely unknown how infections detected by HPV and cytology wax and wane relative to each other. The aim of this analysis was to assess the longitudinal relationship of abnormal cytology and HPV positivity in a 7-year prospective study of 2500 women in Guanacaste, Costa Rica.Methods. At each semiannual or annual visit, cervi ... | 2011 | 22147792 |
| [study for association between high risk human papillomavirus and cervical lesions in the samples from opportunistic screening]. | to investigate the association between hpv genotypes and cervical lesion in hybrid capture 2 (hc2) hpv test positive samples. | 2011 | 21863625 |
| Human papillomavirus genotype distribution and human papillomavirus 16 and human papillomavirus 18 genomic integration in invasive and in situ cervical carcinoma in human immunodeficiency virus-infected women. | Women infected with human immunodeficiency virus (HIV) are at increased risk of developing precancerous and cancerous lesions in cervix because of persistence of oncogenic human papillomavirus (HPV) infection. Scarce information about the HPV genotypes attributed to cervical cancer in the HIV-infected population is available, especially in countries with a low prevalence of this pathology. | 2011 | 21892092 |
| Management of Vulvar Intraepithelial Neoplasia. | Vulvar intraepithelial neoplasia (VIN) is an increasingly common problem, particularly among women in their 40s. The term VIN is used to denote high-grade squamous lesions and is subdivided into usual-type VIN (including warty, basaloid, and mixed VIN) and differentiated VIN. Usual-type VIN is commonly associated with carcinogenic genotypes of human papillomavirus (HPV) and other HPV persistence risk factors, such as cigarette smoking and immunocompromised status, whereas differentiated VIN usua ... | 2011 | 22020407 |
| human papillomavirus 16/18 as04-adjuvanted cervical cancer vaccine: immunogenicity and safety in 15-25 years old healthy korean women. | the study assessed the immunogenicity and safety of human papillomavirus (hpv)-16/18 as04-adjuvanted cervical cancer vaccine in healthy korean women aged 15-25 years. | 2011 | 21860731 |
| Molecular cloning and characterization of a novel human papillomavirus, HPV 126, isolated from a flat wart-like lesion with intracytoplasmic inclusion bodies and a peculiar distribution of Ki-67 and p53. | Infection with certain human papillomavirus types induces warts with specific macroscopic and microscopic features. We observed multiple flat wart-like lesions on the chest, neck and extremities of an adult T-cell leukemia patient. Histologically, atypical intracytoplasmic inclusion bodies currently known to be pathognomonic for genus gamma or mu papillomaviruses were disclosed in some cells of the epidermis showing histological features compatible with flat warts. In the present study, a novel ... | 2012 | 22056388 |
| Safety of quadrivalent human papillomavirus vaccine. | | 2011 | 22077556 |
| p53 degradation activity, expression, and subcellular localization of e6 proteins from 29 human papillomavirus genotypes. | human papillomaviruses (hpvs) are the etiological agents of cervical cancer and other human malignancies. hpvs are classified into high- and low-risk genotypes according to their association with cancer. host cell transformation by high-risk hpvs relies in part on the ability of the viral e6 protein to induce the degradation of p53. we report the development of a cellular assay that accurately quantifies the p53 degradation activity of e6 in vivo, based on the fusion of p53 to renilla luciferase ... | 2012 | 22013048 |
| the impact of anogenital warts on health-related quality of life: a 6-month prospective study. | the burden of anogenital warts will be a determining factor when making decisions about the type of human papillomavirus (hpv) vaccine to be used (bivalent or quadrivalent) and whether to vaccinate males. we conducted a multicenter prospective study to (1) describe the impact of anogenital warts on quality of life and (2) estimate the quality-adjusted life-years (qalys) lost due to anogenital warts. | 2011 | 21934571 |
| clinical performance assessment of five human papillomavirus dna tests using liquid-based cytology samples. | aim: to evaluate the performance of five hpv tests (hybrid capture 2, linear array [la], dna chip, type-specific polymerase chain reaction [pcr], and sequencing) in detecting high-risk (hr) hpv dna and high-grade cervical intraepithelial neoplasia (cin) and cancer. material and methods: a total of 137 women with abnormal cytologies were prospectively enrolled. the diagnostic accuracy of five hpv dna tests in detecting high-grade cin and cancer was assessed, and the concordance among hpv genoty ... | 2011 | 22175246 |
| Factors associated with the seroprevalence of 26 cutaneous and two genital human papillomavirus types in organ transplant patients. | Viral skin infections are commonly present in organ transplant recipients (OTR). In this study, we aimed to identify factors associated with human papillomavirus (HPV) infections in OTR. Patients with solid-organ transplants were recruited from the outpatient nephrology and dermatology clinics in five European countries. Only patients with no current or past skin cancer were included in this analysis. Serum samples were analysed for antibodies to the L1 proteins of 26 cutaneous and two genital H ... | 2012 | 21900419 |
| risk factors for cervical cancer in criminal justice settings. | women in criminal justice settings have an increased prevalence of cervical cancer compared with the general population. however, little is known about abnormal cervical cancer screening results among women in jail and community-based criminal justice settings. thus, the aims of this study were to compare the prevalence of self-reported abnormal papanicolou (pap) test results in women in jail and under community criminal justice supervision and to examine factors associated with abnormal pap tes ... | 2011 | 22004180 |
| human papillomavirus l2 facilitates viral escape from late endosomes via sorting nexin 17. | the human papillomavirus (hpv) l2 capsid protein plays an essential role during the early stages of viral infection, but the molecular mechanisms underlying its mode of action remain obscure. using a proteomic approach, we have identified the adaptor protein, sorting nexin 17 (snx17) as a strong interacting partner of hpv l2. this interaction occurs through a highly conserved snx17 consensus binding motif, which is present in the majority of hpv l2 proteins analysed. using mutants of l2 defectiv ... | 2011 | 22151726 |
| Restriction of human papillomavirus DNA testing in primary cervical screening to women above age 30: systematic review. | Cervical screening with human papillomavirus (HPV) testing is less specific for high-grade cervical intraepithelial neoplasia (=CIN3) than cytology. The aim of this systematic review was to determine whether a restriction of HPV testing to women aged at least 30 years would eliminate the problem. On the basis of the data from randomized controlled trials, we calculated the relative detection of CIN1 and CIN2, and the relative risks of false-positive tests (positive tests without subsequent =CIN3 ... | 2012 | 21968690 |
| A hybrid-capture assay to detect HPV mRNA ratios in cervical specimens. | Human papillomavirus (HPV) DNA screening benefits cervical cancer diagnosis, but a few HPV infections result in cancer. Assays that predict cancer are desirable. A potential biomarker is the ratio of HPV E6-7 over E2 transcripts, which may increase during early cancer progression. Modified hybrid-capture technology detected, in separate wells, HPV E6-7 or E2 mRNA of HPV 16 or HPV 18 in samples. The limit of detection was approximately 1000 copies of in vitro transcribed RNA with linear dynamic r ... | 2012 | 22040847 |
| evaluation of human papilloma virus diagnostic testing in oropharyngeal squamous cell carcinoma: sensitivity, specificity, and prognostic discrimination. | human papillomavirus-16 (hpv16) is the causative agent in a biologically distinct subset of oropharyngeal squamous cell carcinoma (opscc) with highly favorable prognosis. in clinical trials, hpv16 status is an essential inclusion or stratification parameter, highlighting the importance of accurate testing. | 2011 | 21969383 |
| prospective seroepidemiologic study of human papillomavirus and other risk factors in cervical cancer. | several sexually transmitted infections (sti) have been reported to interact with human papillomavirus (hpv) in the etiology of cervical cancer. a large cohort study is required to obtain a both unbiased and stable estimate of their effects. | 2011 | 21994401 |
| Liquid-based cytology and human papillomavirus testing to screen for cervical cancer: a systematic review for the U.S. Preventive Services Task Force. | Screening programs using conventional cytology have successfully reduced cervical cancer, but newer tests might enhance screening. | 2011 | 22006930 |
| human papillomavirus (hpv) detection and papanicolaou cytology in low-resource women in posadas city, misiones, argentina. | the objective of this study was to determine the prevalence of hpv infection and cervical lesions present in women who attended a health center in a low-resource area of the city of posadas, misiones, argentina. cervical cell samples (n = 163) were processed for papanicolaou cytology and hpv-pcr tests. socio-cultural risk factors were estimated using the odds ratio (or, ci 95 %). cervical lesions were detected in 14.7 % of women. the general prevalence of hpv infection was of 38 %. the most comm ... | 2011 | 22274823 |
| human papillomavirus 18 e6 inhibits phosphorylation of p53 expressed in hela cells. | abstract: background: in hpv infected cells p53 function is abrogated by e6 and even ectopically expressed p53 is unable to perform tumor suppressor functions. in addition to facilitating its degradation, e6 may also inhibit p53 transactivity, though the mechanisms are still poorly understood. it has been reported that inhibition of p300, an acetyltransferase responsible for p53 acetylation is inactivated by e6. activation of overexpressed p53 to cause cell growth inhibition is facilitated by i ... | 2012 | 22244155 |
| automated detection of dual p16/ki67 nuclear immunoreactivity in liquid-based pap tests for improved cervical cancer risk stratification. | the papanicolau (pap) test is a routine cytological procedure for early detection of dysplastic lesions in cervical epithelium. a reliable screening method is crucial for triage of women at risk; however manual screening and interpretation are associated with relatively low sensitivity and substantial interobserver diagnostic variability. p16 and ki67 biomarkers have been recently proposed as adjunctive tools in the diagnosis of high-risk human papillomavirus (hrhpv) associated dysplasias to sup ... | 2012 | 22215277 |
| prevalence of human papilloma virus in esophageal carcinomas: a polymerase chain reaction-based study. | objectives: human papilloma virus (hpv) has been repeatedly found in esophageal carcinoma tissues. however, detection rates of hpv dna in these tumors have varied markedly. differences in detection methods, sample types and geographic regions of the sample origin have been suggested as potential causes of this discrepancy. this study was undertaken to analyze the prevalence of hpv in esophageal carcinoma. study design: hpv l1 dna was evaluated in a total of 49 esophageal carcinoma samples, inclu ... | 2012 | 22236750 |
| high-risk human papillomavirus infection in bowen's disease of the nail unit: report of three cases and review of the literature. | background: bowen's disease (bd) of the nail unit is associated with human papillomavirus (hpv) infection. objective: this study aimed to investigate the frequency of high-risk hpv infection, gender, age and digital distribution in this condition. methods: biopsy specimens of 3 consecutive cases with periungual bd were investigated for the presence of hpv dna by in situ hybridization and by polymerase chain reaction (pcr). furthermore, 74 cases of ungual bd conducted with hpv genotyping as repor ... | 2012 | 22269697 |
| incidence of human papillomavirus infection in male sexual partners of women diagnosed with cin ii-iii. | human papillomavirus (hpv) infection is a very common sexually transmitted disease which has been strongly related to cervical cancer and cervical intraepithelial neoplasia (cin), penile cancer and intraepithelial and infiltrating anal squamous cell carcinoma. to describe the hpv status of male sexual partners of women diagnosed with cin ii/iii and to evaluate the practical usefulness of the hpv detection in urine as a reliable marker of genital high-risk hpv infection in men. ninety-one heteros ... | 2012 | 22240393 |
| a new case of primary signet-ring cell carcinoma of the cervix with prominent endometrial and myometrial involvement: immunohistochemical and molecular study and review of the literature. | abstract: background: as a rule, endocervical tumours with signet-ring cell are classed as metastatic extra-genital neoplasms. in a patient aged 45 years, we describe primary cervical signet-ring cell carcinoma (pcsrcc) characterized by prominent endometrial and myometrial involvement, simulating primary endometrial adenocarcinoma with cervical extension. in addition, a review of the literature was made to identify the clinical and pathological features of this rare malignancy. case presentatio ... | 2012 | 22236794 |
| adolescent perceptions of risk and need for safer sexual behaviors after first human papillomavirus vaccination. | to (1) examine perceptions of risk of human papillomavirus (hpv) and other sexually transmitted infections (stis), (2) examine perceived need for safer sexual behaviors, and (3) determine factors associated with less perceived need for safer sexual behaviors, all in the context of receiving the first hpv vaccination. | 2012 | 22213755 |
| the interplay of age stratification and hpv testing on the predictive value of asc-us cytology: results from the athena hpv study. | we have previously shown that human papillomavirus (hpv) genotyping, using the cobas hpv test (roche molecular systems, pleasanton, ca), can be used to identify women with atypical squamous cells of undetermined significance (asc-us) at the highest risk for cervical intraepithelial neoplasia (cin) grade 2 or worse. we investigated the impact of age stratification on the risk of cin 2 or worse in women with asc-us and the performance of hpv genotyping in different age strata. the sensitivity of t ... | 2012 | 22261457 |
| high-risk cutaneous squamous cell carcinoma. | cutaneous squamous cell carcinoma (cscc) is the second most common form of skin cancer and its incidence has increased in recent decades. most csccs are successfully treated by surgery, but local and distant metastases develop in approximately 5% of cases; this proportion is higher in certain forms of cscc with high-risk factors, namely: tumor size >2cm, depth >2mm, clark level ≥iv, perineural invasion, lymphovascular invasion, poor differentiation, certain histologic subtypes (desmoplastic or a ... | 2012 | 22261673 |
| [expression of runx3 in cervical carcinoma and its clinical significance]. | objective to explore the role of runt-related transcription factor 3(runx3) in the tumorgenesis and progression of cervical carcinoma. methods the immunohistochemical staining technique was used to detect the expression of runx3 protein in 25 cases of normal cervix, 34 intraepithelia neoplasia (cin), and 48 cervical carcinomas. sybr greenichimeric fluorescence real-time pcr was applied to detect the expression of runx3 mrna in 10 cases of normal cervix, 24 cin, and 30 cervical carcinomas. result ... | 2011 | 22246363 |
| topical vitamin a treatment of recalcitrant common warts. | abstract: background: common warts (verruca vulgaris) are benign epithelial proliferations associated with human papillomavirus (hpv) infection. salicylic acid and cryotherapy are the most frequent treatments for common warts, but can be painful and cause scarring, and have high failure and recrudescence rates. topical vitamin a has been shown to be a successful treatment of common warts in prior informal studies. case the subject is a healthy, physically-active 30 old female with a 9 year hist ... | 2012 | 22251397 |
| human papillomavirus-positive oral cavity and oropharyngeal cancer patients do not have better quality-of-life trajectories. | objective. to determine the role of human papillomavirus (hpv) status on quality of life (qol) in patients with oral cavity and oropharyngeal squamous cell carcinoma (oscc). since oscc that are associated with high-risk hpv have an improved response to treatment and survival, we hypothesized that patients with these tumors would have better qol trajectories.study design. prospective cohort study.setting. tertiary care academic medical center and 2 affiliated hospitals.subjects and methods. head ... | 2012 | 22275190 |