| identification of high-risk human papillomavirus (hrhpv)-associated genes in early stage cervical squamous cell carcinomas. | this retrospective study investigated gene expression in tumour samples from 38 patients with early stage human papillomavirus (hpv)-associated cervical squamous cell carcinoma (cscc). the patients were divided into two groups based on the presence of viral markers of hpv16 or hpv18 infection. gene expression profiles of tumour samples and the corresponding normal cervical epithelium were analysed using cdna microarrays. several genes showed differential expression between the two groups of hpv- ... | 2011 | 21819702 |
| rate of detection of high-risk hpv with two assays in womenôëñ30years of age. | high-risk (hr) human papillomavirus (hpv) prevalence rates, as determined by the cervista(-«) hpv hr test, in women aged ôëñ30 years in a routine screening population have not been studied. | 2011 | 21724457 |
| implementation of e-bug in denmark. | bacterial resistance to antimicrobial agents in primary healthcare is low in denmark compared with most other european countries. denmark has a vaccination programme for children that recommends immunization against 10 infectious diseases, including a heptavalent pneumococcal conjugate vaccine (pcv7) and a vaccine against human papillomavirus (hpv). outbreaks in schools due to other infectious illnesses are well recognized and have seasonal variations. a quarter of young people have had a sexual ... | 2011 | 21680590 |
| risk of seropositivity to multiple oncogenic human papillomavirus (hpv) types among hiv positive and hiv negative ugandan women. | to understand prospects for human papillomavirus (hpv) mass vaccination in a developing country setting, we studied the co-occurrence of seropositivity to multiple high-risk (hr) hpv types among hiv-positive and hiv-negative ugandan women. our sero-epidemiological study was conducted among 2053 women attending antenatal clinics. sera were analyzed for antibodies to eight hrhpv types of the alpha-7 (18/45) and alpha-9 (16/31/33/35/52/58) species of hpv using a multiplex assay. our results show th ... | 2011 | 21832008 |
| factors associated with initiation and completion of the quadrivalent human papillomavirus vaccine series in an ontario cohort of grade 8 girls. | abstract: background: although over a hundred million dollars have been invested in offering free quadrivalent human papillomavirus (hpv) vaccination to young girls in ontario, there continues to be very little information about its usage. in order to successfully guide future hpv vaccine programming, it is important to monitor hpv vaccine use and determine factors associated with use in this population. methods: linking administrative health and immunization databases, we conducted a population ... | 2011 | 21838921 |
| the value of high-resolution anoscopy in the diagnosis of anal cancer precursor lesions in hiv-positive patients. | anal cancer, although a still rare disease, is being observed in ascending rates among some population segments known to be at risk for the development of the disease. human papillomavirus (hpv) infection, immunodepression and anal intercourse are some factors associated with the development of the malignancy. its similarities to cervical cancer have led to many studies aiming to establish guidelines for detecting and treating precursor lesions of anal cancer, with the goal of prevention. high-r ... | 2011 | 21709956 |
| cervical cancer treatment in africa. | this review is to inform the reader about the current situation with regard to treatment of cervical cancer in africa and the barriers and complexities faced in most african countries. it also reviews the natural history of cervical cancer, the new 2009 international federation of gynecology and obstetrics staging, and current treatment guidelines for cervical cancer. | 2011 | 21734579 |
| the e7 open reading frame acts in cis and in trans to mediate differentiation-dependent activities in the human papillomavirus type 16 life cycle. | human papillomaviruses (hpvs) are the causative agents of several important genital and other mucosal cancers. the hpv16 e7 gene encodes a viral oncogene that is necessary for the continued growth of cancer cells, but its role in the normal, differentiation-dependent life cycle of the virus is not fully understood. the function of e7 in the viral life cycle was examined using a series of mutations of e7 created in the context of the complete hpv16 genome. the effect of these e7 mutations on key ... | 2011 | 21697473 |
| fathers' intentions to accept human papillomavirus vaccination for sons and daughters: exploratory findings from rural honduras. | objectives: little is known about fathers' attitudes toward human papillomavirus (hpv) vaccination in low-resource settings. we sought to determine the awareness of hpv vaccination among honduran fathers, and to assess their intention to accept hpv vaccination for their sons and daughters. methods: we conducted 100 structured interviews of fathers recruited from medical and business settings between may 2007 and june 2008. after assessing baseline knowledge, fathers received a brief explanation ... | 2011 | 21698492 |
| the strong protective effect of circumcision against cancer of the penis. | male circumcision protects against cancer of the penis, the invasive form of which is a devastating disease confined almost exclusively to uncircumcised men. major etiological factors are phimosis, balanitis, and high-risk types of human papillomavirus (hpv), which are more prevalent in the glans penis and coronal sulcus covered by the foreskin, as well as on the penile shaft, of uncircumcised men. circumcised men clear hpv infections more quickly. phimosis (a constricted foreskin opening impedi ... | 2011 | 21687572 |
| the relationship between p16 expression and high-risk human papillomavirus infection in squamous cell carcinomas from sites other than uterine cervix: a study of 137 cases. | p16 is known to be an excellent surrogate marker of human papillomavirus infection in squamous cell carcinoma of the cervix. recent studies have demonstrated a link between human papillomavirus infection and a subset of head and neck squamous cell carcinomas, especially from the oropharynx. the aims of this study were to determine the incidence of p16 expression in squamous cell carcinomas of noncervical origin and to assess its utility as a surrogate marker of human papillomavirus infection in ... | 2011 | 21840041 |
| economic evaluation of policy options for prevention and control of cervical cancer in thailand. | background: the thai healthcare setting has seen patients with cervical cancer experience an increasing burden of morbidity and mortality, a stagnation in the performance of cervical screening programmes and the introduction of a vaccine for the prevention of human papillomavirus (hpv) infection. objective: this study aims to identify the optimum mix of interventions that are cost effective, from societal and healthcare provider perspectives, for the prevention and control of cervical cancer. me ... | 2011 | 21838332 |
| mother-daughter communication and college women's confidence to communicate with family members and doctors about the human papillomavirus and sexual health. | in this study, we examined whether mother-daughter sexuality communication in midadolescence contributes to young women's self-efficacy to consult with family members about sexual health problems, and to talk with physicians about the human papillomavirus (hpv). | 2011 | 21715198 |
| role of high-risk human papillomavirus (hpv) mrna testing in the prediction of residual disease after conisation for high-grade cervical intraepithelial neoplasia. | objective: to evaluate testing for high-risk human papillomavirus (hr hpv) e6/e7 mrna transcripts 6months after conisation for cervical intraepithelial neoplasia grade 2 or worse (cin2+) to determine the risk of residual cin2+. methods: we prospectively followed 344 women treated for cin2+ by conisation. hr hpv mrna testing (pretect hpv-proofer, norchip-«), hr hpv dna testing (amplicor hpv test, roche diagnostics-«) and cytology was performed at 6 and 12months after conisation. biopsies were tak ... | 2011 | 21839500 |
| high prevalence of bk polyomavirus sequences in human papillomavirus-16-positive precancerous cervical lesions. | high- and low-grade cervical lesions were analyzed for the presence of polyomavirus (pyv) and human papillomavirus (hpv) sequences. in precancerous cervical lesions, the overall prevalence of pyv sequences was 44% (41/93). specifically, among the pyv-positive samples, 83% (34/41) tested positive for bk polyomavirus (bkv) sequences, whereas 17% (7/41) were positive for jc-virus. none of the samples were positive for simian virus 40. the presence of bkv dna in high-grade squamous intraepithelial l ... | 2011 | 21837794 |
| colposcopy in special circumstances: pregnancy, immunocompromise, including hiv and transplants, adolescence and menopause. | the true value of colposcopy in pregnancy is under debate; the examination may be more difficult depending on the gestation at which a woman presents. cervical intraepithelial neoplasia does not have an accelerated progression during pregnancy, and treatment is usually deferred until postpartum. the prevalence of cervical intraepithelial neoplasia is greater in women with immune compromise. those with human immunodeficiency have a higher prevalence, more persistence and less regression of human ... | 2011 | 21843974 |
| high-risk hpv dna testing and hpv-16/18 genotyping: what is the clinical application? | there are currently 2 tests approved for clinical use that nonspecifically detect the presence of multiple oncogenic or high-risk human papillomavirus (hpv) types. one hpv genotyping test is also available for use that specifically detects the presence of high-risk hpv types 16 and 18. the purpose of this review was to evaluate the clinical performance of these hpv dna tests and the utility of the tests within current screening recommendations. | 2011 | 21716051 |
| human papillomavirus 13 in a mexican mayan community with multifocal epithelial hyperplasia: could saliva be involved in household transmission? | multifocal epithelial hyperplasia (meh) is a disease of the oral mucosa. human papillomaviruses 13 and 32 have been detected in these lesions. we describe the epidemiology and clinical characteristics of patients with meh in a rural community in the mayan area of mexico with 53 cases and 54 controls. clinical and epidemiological data were collected through a direct interview. oral cell samples were collected with a cytobrush. subjects collected their own saliva sample in a sterile bottle. all sa ... | 2011 | 21697033 |
| induction of human +¦-defensins and psoriasin in vulvovaginal human papillomavirus-associated lesions. | infections with a low-risk type of human papillomavirus (hpv) may lead to genital warts. hpv targets the basal cell layer of epithelial cells. the first line of defense is the innate immune system, which provides nonspecific protection against a variety of pathogens. the antimicrobial peptides (amps) +¦- and +¦-defensins, cathelicidins, psoriasin, and rnase7 are central mediators. | 2011 | 21730203 |
| early effect of the hpv vaccination programme on cervical abnormalities in victoria, australia: an ecological study. | australia introduced a human papillomavirus (hpv) vaccination programme with the quadrivalent hpv vaccine for all women aged 12-26 years between 2007 and 2009. we analysed trends in cervical abnormalities in women in victoria, australia, before and after introduction of the vaccination programme. | 2011 | 21684381 |
| a randomized clinical comparative study of cryotherapy plus photodynamic therapy vs. cryotherapy in the treatment of multiple condylomata acuminata. | cryotherapy cannot destroy subclinical human papillomavirus-infected cells of condylomata acuminata (ca). the topical application of aminolevulinic acid (ala) results in a shallow penetration depth in ca lesions (1). | 2011 | 21729164 |
| hpv vaccination among ethnic minorities in the uk: knowledge, acceptability and attitudes. | background:human papillomavirus (hpv) vaccination offers a unique opportunity for the primary prevention of cervical cancer. studies suggest that knowledge and attitudes about the vaccine are likely to influence uptake. one limitation of most studies assessing hpv vaccine knowledge, attitudes and acceptability is their under representation of ethnic minorities. it is important to ensure that our understanding of hpv knowledge and attitudes include all ethnic groups in the uk. this article review ... | 2011 | 21829204 |
| see-and-treat approaches to cervical cancer prevention for hiv-infected women. | cervical cancer remains the second commonest cancer among women worldwide, and more than 85% of the global burden of this disease occurs in the developing world. hiv-infected women have a higher likelihood of developing persistent high-risk human papillomavirus (hpv) infection, precancer, and invasive cervical cancer than seronegative women. although highly effective primary and secondary prevention strategies are currently available, they remain inaccessible to the vast majority of women. becau ... | 2011 | 21706187 |
| suppression of hpv e6 and e7 expression by baf53 depletion in cervical cancer cells. | deregulation of the expression of human papillomavirus (hpv) oncogenes e6 and e7 plays a pivotal role in cervical carcinogenesis because the e6 and e7 proteins neutralize p53 and rb tumor suppressor pathways, respectively. in approximately 90% of all cervical carcinomas, hpvs are found to be integrated into the host genome. following integration, the core-enhancer element and p105 promoter that control expression of e6 and e7 adopt a chromatin structure that is different from that of episomal hp ... | 2011 | 21821000 |
| detection of human papillomavirus dna in urine. a review of the literature. | the detection of human papillomavirus (hpv) dna in urine, a specimen easily obtained by a non-invasive self-sampling method, has been the subject of a considerable number of studies. this review provides an overview of 41 published studies; assesses how different methods and settings may contribute to the sometimes contradictory outcomes; and discusses the potential relevance of using urine samples in vaccine trials, disease surveillance, epidemiological studies, and specific settings of cervica ... | 2011 | 21818524 |
| detection and genotyping of human papilloma virus in cervical cancer specimens from saudi patients. | to determine the rates and types of human papilloma virus (hpv) infection in cervical cancer specimens from saudi patients. | 2011 | 21697680 |
| why do young women get tested for sexually transmitted infections? evidence from the national longitudinal study of adolescent health. | abstract purpose: public health officials promote sexually transmitted infection (sti) testing as a method to reduce the morbidity of stis. the purpose of this study was to examine what factors are associated with sti testing among young women across various types of stis and to compare relative influences of factors across models. methods: a secondary data analysis of data from add health wave iii was conducted (n=2629). explanatory factors highlighted in qualitative literature were operational ... | 2011 | 21689024 |
| incremental impact of adding boys to current human papillomavirus vaccination programs: role of herd immunity. | our aim was to examine the potential incremental impact of vaccinating boys against human papillomavirus (hpv) on vaccine-type infection in females and males, using an individual-based hpv transmission-dynamic model. under base assumptions (vaccine efficacy = 99%, duration of protection = 20 years, coverage = 70%), vaccinating 12-year-old boys, in addition to girls, resulted in an incremental reduction in hpv-16/18 (hpv-6/11) incidence over 70 years of 16% (3%) in females and 23% (4%) in males. ... | 2011 | 21742835 |
| human papillomavirus genotypes in male genitalia and their concordance among pregnant spouses participating in the finnish family hpv study. | introduction.ôçé genotype-specific concordance among human papillomavirus (hpv)-infected spouses is incompletely assessed. hpv concordance is of importance in counselling hpv-infected subjects and their partners. aim.ôçé to determine hpv-genotype distribution and prevalence in semen and urethral samples of young fathers and their concordance with hpv-genotypes in cervical and oral mucosal samples of their spouses. methods.ôçé in the finnish family hpv study, urethral and semen samples were colle ... | 2011 | 21718450 |
| targeting the human papillomavirus e6 and e7 oncogenes through expression of the bpv1 e2 protein stimulates cellular motility. | expression of the high risk human papillomavirus (hpv) e6 and e7 oncogenes is essential for the initiation and maintenance of cervical cancer. the repression of both was previously shown to result in activation of their respective tumor suppressor targets p53 and prb, and subsequent senescence induction in cervical cancer cells. consequently, viral oncogene suppression is a promising approach for the treatment of hpv positive tumors. one well established method of e6/e7 repression involves the r ... | 2011 | 21835799 |
| the changing picture of high-grade anal intraepithelial neoplasia in men who have sex with men: the effects of 10 years of experience performing high-resolution anoscopy. | ten years ago, we published findings from anal dysplasia screening in a metropolitan surgical practice where the majority of men who have sex with men had biopsy-proven high-grade anal intraepithelial neoplasia. | 2011 | 21730790 |
| safety and reactogenicity of a quadrivalent human papillomavirus (types 6, 11, 16, 18) l1 viral-like-particle vaccine in older adolescents and young adults. | prophylactic vaccination with a quadrivalent hpv (types 6, 11, 16, 18) vaccine (qhpv) has been shown to prevent infection with hpv 6/11/16/18 and associated disease in women and more recently, in men. here we report on the safety and reactogenicity of the qhpv vaccine in males. a total of 4,065 healthy males aged 16-26 years were enrolled into a randomized, placebo-controlled, double-blind trial. subjects were randomized 1:1 to receive qhpv vaccine or placebo at day 1, month 2, and month 6. safe ... | 2011 | 21712645 |
| value of hpv-dna test in women with cytological diagnosis of atypical glandular cells (agc). | objective: this study analyzed whether hpv (human papillomavirus) testing contributes towards defining histological abnormalities in women with atypical glandular cells (agc) diagnosed at cervical cytology. study design: one hundred and eight women with conventional cervical cancer screening smears suggestive of agc not otherwise specified (agc-nos) and favor neoplastic (agc-fn) were consecutively enrolled. all women underwent colposcopic examinations and biopsy was performed according to the cy ... | 2011 | 21680079 |
| anogenital human papillomavirus in sexually abused and nonabused children: a multicenter study. | objectives: to characterize the epidemiology of genital human papillomavirus (hpv) infection in children without previous consensual sexual activity, comparing hpv prevalence by certainty of child sexual abuse (csa). patients and methods: patients presenting for evaluation of csa in 8 sites in atlanta, houston, harrisburg, and new york city were recruited along with patients presenting for unrelated health visits. csa certainty was classified as definite, probable, possible, or no evidence follo ... | 2011 | 21844060 |
| human papillomavirus vaccination uptake and factors related to uptake in a traditional desert city in the united arab emirates. | it is important to assess uptake of a new vaccine. the present survey estimated the uptake of the recently introduced human papillomavirus vaccine (hpvv) in the emirate of abu dhabi and also explored barriers to uptake. a questionnaire survey was conducted in secondary schools, enrolling 334 girls. the uptake percentage was estimated and factors associated with uptake were assessed with multilevel logistic regression. crude vaccination uptake was 53%. factors positively associated with uptake we ... | 2011 | 21729960 |
| penile cancer: what's new? | this article reviews the epidemiology, diagnostic modalities and treatment of localized and advanced penile cancer, with special emphasis on most recent findings from the literature. | 2011 | 21826001 |
| associations of human leukocyte antigen class ii genotypes with human papillomavirus 18 infection and cervical intraepithelial neoplasia risk. | background: only a small proportion of women infected with human papillomavirus type 18 (hpv18) may progress to persistent infection and cervical neoplasia. this community-based cohort study aimed to assess associations with human leukocyte antigen (hla) class ii genotypes for natural infection of hpv18 and subsequent risk of cervical neoplasia. methods: among 10,190 cytologically normal participants, 125 with hpv18 infection were identified by hpv blot kit. hpv18 viral load at study entry was e ... | 2011 | 21692064 |
| implication of human papillomavirus-66 in vulvar carcinoma: a case report. | abstract: | 2011 | 21702970 |
| human papillomavirus serologic follow-up response and relationship to survival in head and neck cancer: a case-comparison study. | abstract: | 2011 | 21740566 |
| Human papillomavirus (HPV) detection using in situ hybridization in histologic samples: correlations with cytologic changes and polymerase chain reaction HPV detection. | Although in situ hybridization (ISH) and polymerase chain reaction (PCR) have extensively been used on cytology specimens, there have been limited reports of the usefulness of these techniques in relation to confirmed histologic findings. In this study, we used PCR and ISH to detect human papillomavirus (HPV) in cytologic and histologic specimens, respectively. By using positive and negative likelihood ratios, we attempted to identify any predictive role of ISH testing alone or in combination wi ... | 2011 | 21685039 |
| Promoter methylation analysis of WNT/+¦-catenin signaling pathway regulators to detect adenocarcinoma or its precursor lesion of the cervix. | Cervical adenocarcinoma (AdCA) and adenocarcinoma in situ (ACIS) are frequently missed in cytology-based screening programs. Testing for high-risk human papillomavirus (hrHPV) improves their detection, but novel ACIS/AdCA specific biomarkers are needed to increase specificity for these lesions. Novel markers may be deduced from the WNT/+¦-catenin signaling pathway, which is aberrantly activated during cervical carcinogenesis. | 2011 | 21726894 |
| p63 is necessary for the activation of human papillomavirus late viral functions upon epithelial differentiation. | the late phase of the human papillomavirus (hpv) life cycle is linked to epithelial differentiation, and we investigated the factors that regulate this process. one potential regulator is p63, a member of the p53 family of proteins, which modulates epithelial development, as well as proliferation capability, in stem cells. in this study, we examined the role of p63 in the hpv life cycle using a lentiviral knockdown system for p63. in epithelial cells, the δn truncated isoforms of p63 predominate ... | 2011 | 21715473 |
| alaska native adolescent views on cervical cancer, the human papillomavirus (hpv), genital warts and the quadrivalent hpv vaccine. | to understand the knowledge levels, attitudes and perceptions of alaska native adolescent girls about cervical cancer, hpv, genital warts and the hpv vaccine. | 2011 | 21703130 |
| Clustering of human papillomavirus (HPV) types in the male genital tract: the HPV in men (HIM) study. | To evaluate clustering patterns of prevalent infection with multiple human papillomavirus (HPV) types in 3677 men from the HPV in Men (HIM) study. | 2011 | 21908729 |
| Pleomorphic (spindle and squamous cell) carcinoma arising in a peripheral mixed squamous and glandular papilloma in a 70-year-old man. | Solitary papillomas of the bronchial tree are rare, particularly in the distal airways. When encountered, solitary papillomas are not frequently found to undergo malignant transformation. When this does happen, it is usually a squamous cell carcinoma arising in a human papillomavirus-associated squamous papilloma (usually in a central airway). Here we report a unique case of pleomorphic (spindle and squamous cell) carcinoma arising in a mixed glandular and squamous papilloma without human papill ... | 2011 | 21970492 |
| Multiple human papillomavirus infections and type competition in men. | Background. There is little information on multiple human papillomavirus (HPV) infections and the potential for type competition in men, yet competition may impact the type-specific efficacy of HPV vaccination. Methods. Among 2702 uncircumcised men in Kisumu, Kenya, who were seronegative for human immunodeficiency virus, the observed numbers of HPV types detected were compared with the expected number, which was simulated under the assumption of independent infections. To assess the potential fo ... | 2012 | 22058418 |
| the role of the human papillomavirus in oropharyngeal cancer. | in recent years there has been an overall decrease in cancers of the oral cavity, and a concurrent increase in cancers in specific sites of the posterior oral cavity and oropharynx in the united states. there is increasing evidence that the human papillomavirus may play a role in the development of oropharyngeal squamous cell carcinoma. in this article we review the biology and risk factors associated with hpv and oropharyngeal carcinoma, and recent data suggesting that this type of cancer may b ... | 2011 | 22013861 |
| [immunohistochemical staining of p16 in squamous cell carcinomas of the genital and extragenital area]. | positive immunostaining for the tumor suppressor protein p16 is associated with the presence of mucosal or αsubtypes of human papillomavirus (hpv) in cervical and genital squamous cell carcinoma (scc). the aim of this study was to determine whether p16 immunostaining is also associated with mucosal hpv in extragenital scc. | 2011 | 21944770 |
| another look at the human papillomavirus vaccine experience in canada. | policy debates about immunization frequently focus on classic trade-offs between individual versus collective well-being. publicly funded immunization programs are usually justified on the basis of widespread public benefit with minimal individual risk. we discuss the example of the policy process surrounding the adoption of the human papillomavirus (hpv) vaccine in canada to consider whether public good arguments continue to dominate immunization policymaking. specifically, we show how a range ... | 2011 | 21852642 |
| distribution of hpv genotypes in cervical intraepithelial lesions and cervical cancer in tanzanian women. | abstract: | 2011 | 22081870 |
| Visual inspection methods for cervical cancer prevention. | The need for simple, cost-effective screening approaches for cervical cancer prevention in low-resource countries has led to the evaluation of visual screening with 3-5% acetic acid. The low reproducibility and wide variation in accuracy reflect the subjective nature of the test. Pooled sensitivity, specificity, positive and negative predictive values were 80%, 92%, 10% and 99%, respectively, for detecting cervical intraepithelial neoplasia grade 2 or worse lesions. Realistic sensitivity of a qu ... | 2011 | 22075441 |
| Treatment of HPV with hypnosis--psychodynamic considerations of psychoneuroimmunology: a brief communication. | There is increasing evidence that the hypnotic cure of warts (infection by the human papilloma virus or HPV) results from activation of an immune response, but whether this is cellular or systemic is unknown. The hypnosis can be by direct suggestion or analytical hypnotherapy when indicated. The evidence is reviewed, and 4 clinical cases suggesting cellular immune response are presented. | 2011 | 21867375 |
| [the incidence of human papilloma virus associated vulvar cancer in younger women is increasing and wide local excision with sentinel lymph node biopsie has become standard]. | sentinel lymph node (sln) dissections have been shown to be sensitive for the evaluation of nodal basins for metastatic disease and are associated with decreased short-term and long-term morbidity when compared with complete lymph node dissection. there has been increasing interest in the use of sln technology in gynecologic cancers. this review assesses the current evidence-based literature for the use of sln dissections in gynecologic malignancies. | 2011 | 21968892 |
| Bacterial vaginosis and the natural history of human papillomavirus. | To evaluate associations between common vaginal infections and human papillomavirus (HPV). | 2011 | 21869857 |
| biomarkers of oxidant load and type-specific clearance of prevalent oncogenic human papillomavirus infection: markers of immune response? | human papillomavirus (hpv) infection is the cause of cervical cancer. increased production of reactive oxygen species (ros) maybe the common mechanism through which hpv-cofactors (i.e., smoking and inflammation) influence duration of infections. biomarkers of total oxidant load may serve as cumulative measures of ros exposure due to these cofactors. therefore, we conducted a study evaluating the association between biomarkers of oxidant load and duration of hpv infections, early hpv natural hist ... | 2011 | 21858808 |
| Usefulness of CINtec® PLUS p16/Ki-67 double-staining in cytological screening of cervical cancer. | This study evaluated the usefulness of p16(INK4a)/Ki-67 as a new biomarker in the diagnosis of human papillomavirus (HPV)-related cervical lesions. | 2011 | 21986167 |
| Feasibility of self-sampling and human papillomavirus testing for cervical cancer screening in First Nation women from Northwest Ontario, Canada: a pilot study. | Background The incidence of cervical cancer is up to sixfold higher among First Nation women in Canada than in the general population. This is probably due to lower participation rates in cervical cancer prevention programmes. Objective To raise screening participation in this underserved population by launching an alternative approach to (Pap)anicolaou testing in a clinic-namely, vaginal self-sampling followed by human papillomavirus (HPV) diagnostics. Methods Good relationships were establis ... | 2011 | 22021733 |
| project genesis: self-reported religiosity and spirituality and sexual risk-taking in young african-american women attending a historically african-american college. | this pilot study explored the relationship between self-reported religiosity, spirituality, and sexual risk-taking. the participants were a convenience sample of (n = 100) female students attending a historically african-american college (hbcu) in the south. on this predominantly female campus, students completed an anonymous health-risk survey, plus additional items, to measure their religiosity and spirituality. correlation analysis revealed that although these students reported a high degree ... | 2011 | 21888148 |
| human papillomavirus genotypes in iranian patients with cervical cancer. | the aim of this study was to determine the frequency of hpv genotypes isolated from cervical intra-epithelial neoplasia grade iii and invasive carcinomas of iranian patients. a total of 94 cases were selected in five years from 2003 to 2007. after nucleic acid purification, real-time pcr was performed by means of gp5+/gp6+ primers. subsequently, pcr products were sequenced, on the basis of which a phylogenetic tree was constructed. negative samples and twelve randomly selected positive samples w ... | 2011 | 22041132 |
| Tuberculosis and Oncogenic HPV: Potential Co-infections in Women at High-risk of Cervical Cancer in Rural China. | The study was embedded in Shanxi Province Cervical Cancer Screening Study II with the aim of examining the association between history of diagnosed tuberculosis or cervical inflammation and oncogenic human papillomavirus (HPV) infection, persistent oncogenic HPV infection, cervical intraepithelial neoplasia grade 3 or cervical cancer (CIN3+) in an isolated rural population of China. A total of 8,798 women were recruited for cervical cancer screening and an interviewer-administered questionnaire. ... | 2011 | 22126473 |
| Epidemiology and burden of HPV infection and related diseases: implications for prevention strategies. | Human papillomavirus (HPV) infection is a necessary, although not sufficient cause of cervical cancer. Globally, HPV infection accounts for an estimated 530,000 cervical cancer cases (~270,000 deaths) annually, with the majority (86% of cases, 88% of deaths) occurring in developing countries. Approximately 90% of anal cancers and a smaller subset (<50%) of other cancers (oropharyngeal, penile, vaginal, vulvar) are also attributed to HPV. In total, HPV accounts for 5.2% of the worldwide cancer bu ... | 2011 | 21962466 |
| Human papillomavirus in vaginal intraepithelial neoplasia. | There are limited data on the prevalence and distribution of human papillomavirus (HPV) genotypes in vaginal intraepithelial neoplasia (VAIN). We sought to clarify this issue in a series of 450 VAIN cases with a confirmed diagnosis between 1990 and 2006. HPV genotyping was performed using paraffin-embedded specimens and polymerase chain reaction (PCR)-based methods. Multiple HPV types were validated by E6 type-specific PCR and direct sequencing. The HPV genotypes of the vaginal and cervical neop ... | 2011 | 22095387 |
| Oral sex practices, oral human papillomavirus and correlations between oral and cervical human papillomavirus prevalence among female sex workers in Lima, Peru. | Few data exist on oral human papillomavirus (HPV) prevalence in female sex workers (FSWs). Information regarding oral sex practices of 185 Peruvian FSWs, 18-26 years of age, was obtained via survey and compared with HPV testing results of oral rinse samples. Oral HPV prevalence was 14/185 (7.6%); four (28.9%) HPV genotypes were carcinogenic. One hundred and eighty-two participants reported having had oral sex; 95% reported condom use during oral sex with clients and 9.5% with partners. Women who ... | 2011 | 22096051 |
| Eradication of large tumors expressing human papillomavirus E7 protein by therapeutic vaccination with E7 fused to the extra domain a from fibronectin. | Cervical carcinoma is one of the most common cancers in women worldwide. It is well established that chronic infection of the genital tract by various mucosatropic human papillomavirus (HPV) types causes cervical cancer. Cellular immunity to E7 protein from HPV (HPVE7) has been associated with clinical and cytologic resolution of HPV-induced lesions. Thus, we decided to test if targeting of HPVE7 to dendritic cells using a fusion protein containing the extra domain A (EDA) from fibronectin, a na ... | 2011 | 21898393 |
| [Detection of human papillomavirus in gingival fluid of Venezuelan HIV patients with periodontal disease]. | Evidence suggests that viruses may be involved in the activation of periodontal disease, allowing the overgrowth of periodontal pathogens. The purpose of the present study was to detect the presence of Human Papillomavirus (HPV) in gingival crevicular fluid (GCF) in HIV+ Venezuelan patients with periodontal disease. We evaluated GCF samples from 20 HIV+ patients with periodontal disease from the Infectious Disease Center, Faculty of Dentistry, Central University of Venezuela, and were clinically ... | 2011 | 21950192 |
| diagnostic implications of l1, p16, and ki-67 proteins and hpv dna in low-grade cervical intraepithelial neoplasia. | the expressions of p16, ki-67, and l1 proteins and human papillomavirus dna were investigated using polymerase chain reaction (hpv/pcr) and catalyzed signal-amplified colorimetric dna in situ hybridization (csac/ish) as potential molecular markers for the diagnosis and transforming potential of low cervical intraepithelial neoplasia (cin1). ki-67 and p16 protein expression increased linearly from control cases to more dysplastic cases (cin1, cin2, and cin3), peaking in squamous cell carcinoma ca ... | 2011 | 21979598 |
| type-specific human papillomavirus infections among young heterosexual male and female sti clinic attendees. | baseline genotype-specific human papillomavirus (hpv) prevalence rates and associated risk factors per gender enable future assessment of the impact of vaccination on hpv dynamics. | 2012 | 22183851 |
| persistence of type-specific human papillomavirus infection and increased long-term risk of cervical cancer. | human papillomavirus (hpv) persistence is the pivotal event in cervical carcinogenesis. we followed a large-scale community-based cohort for 16 years to investigate the role of genotype-specific hpv persistence in predicting cervical cancer including invasive and in situ carcinoma. | 2011 | 21900119 |
| zinc acetate/carrageenan gels exhibit potent activity in vivo against high-dose herpes simplex virus 2 vaginal and rectal challenge. | topical microbicides that block the sexual transmission of hiv and herpes simplex virus 2 (hsv-2) are desperately needed to reduce the incidence of hiv infections worldwide. previously we completed phase 3 testing of the carrageenan-based gel carraguard. although the trial did not show that carraguard is effective in preventing hiv transmission during vaginal sex, it did show that carraguard is safe when used weekly for up to 2 years. moreover, carraguard has in vitro activity against human papi ... | 2012 | 22064530 |
| Codon usage roles in human papillomavirus. | Human papillomavirus (HPV) genomes, similar to other virus genomes, frequently have a G + C content significantly different from their host species. The HPV genomes show a strong codon usage bias to 18 codons, with 14 showing T at the third position amongst degenerately encoded amino acids. The codon usage pattern in HPV genome plays an important role, which regulates low or non-translational expression of the viral capsid genes and results in very weak protein expression of oncogenes in a wide ... | 2011 | 22025363 |
| Acceptability of self-collected human papillomavirus specimens as a primary screen for cervical cancer. | The aim of this study was to compare the acceptability of self-collected vs clinician-collected human papillomavirus (HPV) tests. Utilising a cross-sectional approach, 250 non-pregnant, 25-60-year-old women from Leon, Nicaragua self-collected vaginal swabs and brushes for HPV and received a pelvic examination for liquid-based cytology and reflex HPV. Subjects underwent colposcopy, with biopsy if indicated, and completed questionnaires comparing their perceptions of HPV testing methods. Acceptabi ... | 2012 | 22185546 |
| Comparison of the INNO-LiPA and PapType assays for detection of human papillomavirus in archival vulva dysplasia and/or neoplasia tissue biopsy specimens. | INNO-LiPA and PapType human papillomavirus (HPV) genotyping assays were compared for detection of HPV genotypes on archival vulvar tissue. The INNO-LiPA assay detected 49 HPV-16 infections, compared with 47 detected by the PapType assay. The INNO-LiPA assay detected amplifiable DNA in 59 (91%) biopsy specimens, compared with 57 (88%) specimens for which amplifiable DNA was detected by the PapType assay. The two genotyping assays were highly comparable. | 2011 | 21940480 |
| comparing bivalent and quadrivalent human papillomavirus vaccines: economic evaluation based on transmission model. | to compare the effect and cost effectiveness of bivalent and quadrivalent human papillomavirus (hpv) vaccination, taking into account differences in licensure indications, protection against non-vaccine type disease, protection against disease related to hpv types 6 and 11, and reported long term immunogenicity. | 2011 | 21951758 |
| Loss of the a2ß1 integrin alters human papilloma virus-induced squamous carcinoma progression in vivo and in vitro. | Expression of the a2ß1 integrin, a receptor for collagens and laminin, is altered during tumor progression. Recent studies have linked polymorphisms in the a2 integrin gene with oral, squamous cell carcinoma (SCC). To determine the a2ß1 integrin's role in SCC progression, we crossed a2-null mice with K14-HPV16 transgenic animals. Pathological progression to invasive carcinoma was evaluated in HPV-positive, a2-null (HPV/KO) and HPV-positive, wild-type (HPV/WT) animals. a2ß1 integrin expression st ... | 2011 | 22046385 |
| Incorporating Calibrated Model Parameters into Sensitivity Analyses: Deterministic and Probabilistic Approaches. | Objective: The aim of this study was to examine how calibration uncertainty affects the overall uncertainty of a mathematical model and to evaluate potential drivers of calibration uncertainty. Methods: A lifetime Markov model of the natural history of human papillomavirus (HPV) infection and cervical disease was developed to assess the cost effectiveness of a hypothetical HPV vaccine. Published data on cervical cancer incidence and mortality and prevalence of pre-cursor lesions were used as end ... | 2011 | 22149631 |
| cervical cancer in the screening era: who fell victim in spite of successful screening programs? | to compare profiles of a prescreening and screening cohort of women with cervical cancer regarding histopathology and clinical variables in order to identify those remaining at risk despite successful screening programs. by analyzing these profiles we hope to improve future screening methods. | 2011 | 21860732 |
| The human papillomavirus type 16 E5 oncoprotein translocates calpactin I to the perinuclear region. | The human papillomavirus type 16 (HPV-16) E5 oncoprotein is embedded in membranes of the endoplasmic reticulum and nuclear envelope with its C terminus exposed to the cytoplasm. Among other activities, E5 cooperates with the HPV E6 oncoprotein to induce koilocytosis in human cervical cells and keratinocytes in vitro. The effect of E5 on infected cells may rely on its interactions with various cellular proteins. In this study we identify calpactin I, a heterotetrameric, Ca(2+)- and phospholipid-b ... | 2011 | 21849434 |
| human papillomavirus type-specific prevalence in women with cervical intraepithelial neoplasm in western china. | hpv type-specific prevalence was studied in 600 cases of cervical intraepithelial neoplasm in western china by genoarray test. hpv 16 and 58 were the most prevalent types with the prevalence of 37.8% or 21.8% respectively. hpv 18 or 45 was uncommon type. the result shows different type distributions from that of other regions, which is important evidence for the selection of future genotypes in hpv vaccines in western china. | 2011 | 22170939 |
| Analysis of CpG methylation sites and CGI among human papillomavirus DNA genomes. | ABSTRACT: BACKGROUND: The Human Papillomavirus (HPV) genome is divided into early and late coding sequences, including 8 open reading frames (ORFs) and a regulatory region (LCR). Viral gene expression may be regulated through epigenetic mechanisms, including cytosine methylation at CpG dinucleotides. We have analyzed the distribution of CpG sites and CpG islands/clusters (CGI) among 92 different HPV genomes grouped in function of their preferential tropism: cutaneous or mucosal. We calculated t ... | 2011 | 22118413 |
| [results of the first human papilloma virus center in hungary (2007-2011)]. | human papilloma virus (hpv) is the most common sexually transmitted infection in the 21st century. it has been established that infections with specific hpv types are contributing factors to cervical cancer. approximately 99.7% of cervical cancers are associated with high risk hpv types. hpv testing plays an important role in the prevention, by decreasing the prevalence and the mortality of cervical cancer. there are 16 hpv-centers operating in hungary, in which patients undergo hpv screening, c ... | 2011 | 22011366 |
| Survival in patients with human papillomavirus positive tonsillar cancer in relation to treatment. | The incidence of tonsillar cancer and the proportion of human papillomavirus (HPV) positive tonsillar cancer cases have increased in the last decades. In parallel, treatment for tonsillar cancer has been intensified e.g., by accelerated radiotherapy, and chemotherapy, resulting in more side effects. Patients with HPV-positive tonsillar cancer have better prognosis than those with HPV-negative tumors, and the former group could hypothetically benefit from reduced, less-toxic treatment without com ... | 2011 | 22038860 |
| human papillomavirus vaccination recommendation may be linked to reimbursement: a survey of virginia family practitioners and gynecologists. | concerns have been raised about gynecologists as vaccinators. this survey evaluated use of the human papillomavirus (hpv) vaccine, attitudes, and barriers among gynecologists and family practitioners for differences between the 2 specialties. | 2011 | 21906978 |
| combined e7-dendritic cell-based immunotherapy and human sodium/iodide symporter radioiodine gene therapy with monitoring of antitumor effects by bioluminescent imaging in a mouse model of uterine cervical cancer. | using a uterine cervical cancer cell line expressing human papillomavirus (hpv) 16 e7 antigen and bioluminescent imaging (bli), we evaluated the therapeutic potential of combined immunotherapy using transfected dendritic cells (dc-e7) and human sodium/iodide symporter (hnis) radioiodine gene therapy in a xenograft animal cancer model. dendritic cells expressing either e7 antigen (dc-e7) or no-insert (dc-no insert) were made for immunization materials, and murine uterine cervical cancer cell line ... | 2011 | 22091632 |
| appalachian and non-appalachian pediatricians' encouragement of the human papillomavirus vaccine: implications for health disparities. | background: in medically underserved regions such as appalachia, cervical cancer incidence and mortality are higher than the general u.s. population; therefore, it is important for pediatricians to encourage parents to have their daughters vaccinated against the human papillomavirus (hpv). unfortunately, little is known about the predictors of pediatricians' encouragement of the hpv vaccine among medically underserved populations. the current study compared attitudes and behaviors of pediatricia ... | 2011 | 21907591 |
| [genital human papillomavirus (hpv) infection in women in the province of asti (italy)]. | the aim of this study was to estimate the prevalence of hpv infection in women in the general population and identify associated risk factors. five hundred women participating in a cervical cancer screening program were included in the study which was performed in asti between april 2005 and october 2005. the prevalence of hpv infection was 10.6%. the most common genotypes were types 18, 16, 51 and 31. cigarette smoke and oral contraceptive use were found to be significantly associated with infe ... | 2011 | 22033201 |
| assessment of herd immunity from human papillomavirus vaccination. | | 2011 | 22115067 |
| human papillomavirus infection, vaccination, and cervical cancer communication: the protection dilemma faced by women in southern appalachia. | human papillomavirus is the most frequently occurring sexually transmitted infection and has been recognized as the necessary cause of cervical cancer. understanding the shift in public awareness caused by recent changes to cervical prevention is critical to addressing cervical cancer disparities in appalachia. since the human papillomavirus vaccine was approved for prevention, little data have been collected regarding human papillomavirus risk assessment and vaccine perceptions among appalachia ... | 2011 | 22185292 |
| human papillomavirus genotype prevalence in cervical biopsies from women diagnosed with cervical intraepithelial neoplasia or cervical cancer in fiji. | there is currently limited information about human papillomavirus (hpv) genotype distribution in women in the south pacific region. this study's objective was to determine hpv genotypes present in cervical cancer (cc) and precancers (cervical intraepithelial lesion (cin) 3) in fiji. | 2011 | 21851773 |
| comparative performance of human papillomavirus dna testing using novel sample collection methods. | to explore alternative cervical cancer screening approaches in an underserved population, we compared the performance of human papillomavirus (hpv) dna assays in combination with different sample collection methods for primary cervical screening in the mississippi delta region. three specimens were collected from women aged 26 to 65 years who were either routinely undergoing screening (n = 252) or not (n = 191): clinician-collected cervical specimens, clinician-collected cervicovaginal specimens ... | 2011 | 21998422 |
| binding site specificity and factor redundancy in activator protein-1-driven human papillomavirus chromatin-dependent transcription. | activator protein-1 (ap-1) regulates diverse gene responses triggered by environmental cues and virus-induced cellular stress. although many signaling events leading to ap-1 activation have been described, the fundamental features underlying binding site selection and factor recruitment of dimeric ap-1 complexes to their target genes remain mostly uncharacterized. using recombinant full-length human ap-1 dimers formed between c-jun and fos family members (c-fos, fosb, fra-1, fra-2) for dna bindi ... | 2011 | 21937452 |
| [influence of the use of oral contraceptives as risk factors for human papillomavirus infection and cervical intraepithelial neoplasia]. | to study the influence of oral contraception use as risk factor for human papillomavirus infection (hpv) and progression to cervical intraepithelial neoplasia (cin). | 2005 | 21961342 |
| high-risk hpv infection after five years in a population-based cohort of chilean women. | abstract: background: the need to review cervical cancer prevention strategies has been triggered by the availability of new prevention tools linked to human papillomavirus (hpv): vaccines and screening tests. to consider these innovations, information on hpv type distribution and natural history is necessary. this is a five-year follow-up study of gynecological high-risk (hr) hpv infection among a chilean population-based cohort of women. findings: a population-based random sample of 969 women ... | 2011 | 22087645 |
| squamous cell carcinoma of the scalp associated with human papillomavirus type 16. | | 2011 | 21896422 |
| comparison of the immunogenicity of the human papillomavirus (hpv)-16/18 vaccine and the hpv-6/11/16/18 vaccine for oncogenic non-vaccine types hpv-31 and hpv-45 in healthy women aged 18-45 years. | protection against oncogenic non-vaccine types (cross-protection) offered by human papillomavirus (hpv) vaccines may provide a significant medical benefit. available clinical efficacy data suggest the two licensed vaccines (hpv-16/18 vaccine, glaxosmithkline biologicals [gsk], and hpv-6/11/16/18 vaccine, merck & co., inc.) differ in terms of protection against oncogenic non-vaccine hpv types -31/45. the immune responses induced by the two vaccines against these two non-vaccine hpv types (cross-r ... | 2011 | 22048172 |
| Compliance with recommended dosing intervals for HPV vaccination among females, 13-17 years, National Immunization Survey-Teen, 2008-2009. | Data from the 2008 and 2009 National Immunization Survey-Teen were analyzed to determine age at initiation of the human papillomavirus vaccine (HPV) series among females 13-17 years (n=7594) and assess compliance with the recommended HPV dosing intervals. Among females who initiated the HPV series, 56.7% of females<13 years at the time of the HPV vaccine recommendation publication did so by age 13; while the majority of females 13-14 and 15-17 years at the time of the recommendation publication ... | 2012 | 22119587 |
| extracapsular spread and adjuvant therapy in human papillomavirus-related, p16-positive oropharyngeal carcinoma. | background: extracapsular spread (ecs) is commonly used to justify adjuvant chemotherapy in patients with head and neck cancer. the role of ecs as a prognosticator and adjuvant therapy determinant in surgically resected, human papillomavirus-related oropharyngeal squamous cell carcinoma (opscc), however, has never been determined. methods: of 210 oropharynx patients in a prospective transoral laser microsurgery database, 152 patients who had p16-positive primary opscc and pathologically positive ... | 2011 | 22086669 |
| Primary human cervical carcinoma cells require human papillomavirus E6 and E7 expression for ongoing proliferation. | Repression of human papillomavirus (HPV) E6 and E7 oncogenes in established cervical carcinoma cell lines causes senescence due to reactivation of cellular tumor suppressor pathways. Here, we determined whether ongoing expression of HPV16 or HPV18 oncogenes is required for the proliferation of primary human cervical carcinoma cells in serum-free conditions at low passage number after isolation from patients. We used an SV40 viral vector expressing the bovine papillomavirus E2 protein to repress ... | 2012 | 22056390 |
| Human Papillomavirus Vaccine Intention Among College Men: What's Oral Sex Got to Do With It? | Abstract Objective: To identify associations between engaging in oral sex and perceived risk of oral cancer among college men. Also, to identify associations, and their moderating factors, between oral sex and human papillomavirus (HPV) vaccine acceptance. Methods: Young men were recruited from 2 university campuses in the South (N = 150). Men completed an audio computer-assisted self-administered interview. Results: With the exception of receiving fellatio, each measure of oral sex behavior ... | 2012 | 22171724 |
| screening still the "best buy" for tackling cervical cancer. | | 2011 | 21897481 |
| vaccine-preventable diseases and their impact on latin american children. | a joint meeting of the latin american society of pediatric infectious diseases, the dominican society of pediatrics and the dominican society of vaccinology was held in the dominican republic. this report highlights the most relevant issues that were presented and discussed about vaccine-preventable diseases, their epidemiology and impact in latin american children, the need to move forward and expand national immunization programs and the economical and political obstacles to introduce ?new? va ... | 2011 | 22085169 |