| relationship of porphyromonas gingivalis with glycemic level in patients with type 2 diabetes following periodontal treatment. | the aim of this study was to assess the relationship between serum glycemic levels and subgingival microbial profile alteration following periodontal treatment in patients with type 2 diabetes mellitus. | 2008 | 18582336 |
| [current status of external quality assessment of syphilis test in korea]. | current status of external quality assessment (eqa) of laboratory tests for syphilis in korea was analyzed to find out the problems that should be improved in the future. | 2008 | 18594173 |
| cost effectiveness of enzyme immunoassay and immunoblot testing for the diagnosis of syphilis. | the burden of disease and associated health-care costs of syphilis are significant despite widespread screening and treatment. our objective was to conduct an economic evaluation using a simulation model when comparing enzyme immunoassay (eia) initial testing and inno-lia (il) confirmatory testing (eia + il) with rapid plasma reagin (rpr) initial testing and treponema pallidum particle agglutination assay (tppa) and fluorescent treponemal antibody absorption assay (fta-abs) confirmatory testing ... | 2008 | 18595877 |
| periodontal status of patients with dentin dysplasia type i: report of three cases within a family. | dentin dysplasia type i (ddi) is a rare hereditary disturbance of dentin formation. it is characterized by clinically normal-appearing crowns; obliteration of pulp chambers; and short, blunted and malformed roots that are commonly associated with periodontal attachment loss (pal). in this context, we report three cases within a family with similar clinical and radiographic features of ddi but with differing microbiologic and periodontal conditions. | 2008 | 18597615 |
| influence of mother vdrl titers on the outcome of newborns with congenital syphilis. | congenital syphilis still represents a significant public health problem worldwide, and particularly in developing countries. despite years of research on different clinical and immunological features, many physiopathological aspects still lacks of knowledge, one of them the role of immune response against treponema pallidum by infected mothers on the birth outcomes, e.g. birthweight. in this study we analyzed if the mother vdrl titers were significantly associated with the birthweight of newbor ... | 2008 | 18600205 |
| [a case of gastric syphilis with duodenal involvement]. | | 2008 | 18604133 |
| cost-effectiveness of rapid point-of-care prenatal syphilis screening in sub-saharan africa. | syphilis continues to be an important public health problem among pregnant women in sub-saharan africa with prevalence rates as high as 17%. pregnant women are a critical population to screen to prevent the devastating consequences of infection to their unborn children. although screening and appropriate treatment of infected pregnant women can prevent fetal and maternal complications, traditional screening algorithms requiring multiple tests have proven to be difficult to implement in resource- ... | 2008 | 18607319 |
| [on the article "syphilis et grossesse" j gynecol obstet biol reprod 2008;37, hors-série 1:f29-f33]. | | 2008 | 18614296 |
| an engineered folded plp-bound monomer of treponema denticola cystalysin reveals the effect of the dimeric structure on the catalytic properties of the enzyme. | cystalysin, a dimeric pyridoxal 5'-phosphate (plp)-dependent lyase, is a virulence factor of the human oral pathogen treponema denticola. guided by bioinformatic analysis, two interfacial residues (leu57 and leu62) and an active site residue (tyr64*), hydrogen-bonded with the plp phosphate group of the neighboring subunit, have been mutated. the wild-type and the l57a, l62a, y64*a, l57a/l62a, l57a/y64*a, l57a/l62a/y64*a mutants, all having a c-terminal histidine tag, have been constructed, expre ... | 2009 | 18618696 |
| clinical challenges and images in gi. syphilitic sigmoiditis complicated by membranous nephropathy. | | 2008 | 18619452 |
| analysis of a growth-phase-regulated two-component regulatory system in the periodontal pathogen treponema denticola. | nothing is currently known regarding the global regulatory networks of treponema denticola and other oral spirochetes. in this report, we assess the properties and potential phosphotransfer capability of a putative two-component regulatory system (tcs) of t. denticola that is formed by the products of open reading frames tde0032 (a sensor kinase) and tde0033 (a response regulator), henceforth designated atcs and atcr, respectively. using pcr and dna sequence analyses, atcs and atcr were demonstr ... | 2008 | 18621891 |
| nontreponemal tests in the diagnosis of neurosyphilis: an evaluation of the venereal disease research laboratory (vdrl) and the rapid plasma reagin (rpr) tests. | the venereal disease research laboratory (vdrl) test has long been considered the best serological test for the diagnosis of neurosyphilis. the goal of this study was to find out if the rapid plasma reagin (rpr) could be an alternative to the vdrl. cerebrospinal fluid (csf) and sera samples from patients in the following stages of syphilis were tested: 8 had symptomatic and 16 asymptomatic neurosyphilis, 4 were in the primary stage, 6 had secondary syphilis, and 92 were in the latent stage. we h ... | 2008 | 18623120 |
| syphilis: an update. | | 2008 | 18624050 |
| the sixteen-year trend of syphilis in turkey: data from blood donors. | this study was conducted in order to determine the prevalence and trends of antibodies to syphilis among turkish blood donors (bds) at the 22 national blood transfusion service, kizilay, between 1989 and 2004. among the 6,240,130 bds, a reactive result was obtained with the rapid plasma reagin test for 6864 donors (0.11%). a serious increasing trend was observed between 1989 and 1992 (41/100.000 versus 92/100.000 cases, p = 0.003, ci 95, 33-107), in 1998, the rates were observed to have increase ... | 2008 | 18628555 |
| clinical and therapeutic aspects of dementia in syphilis and lyme disease. | | 2008 | 18631797 |
| biology and neuropathology of dementia in syphilis and lyme disease. | | 2008 | 18631798 |
| microorganisms in root canal-treated teeth from a german population. | posttreatment apical periodontitis is usually associated with persistent or secondary intraradicular infection. this study evaluated the presence and relative levels of 28 bacterial taxa in treated root canals of teeth with posttreatment apical periodontitis from german patients using 16s ribosomal rna (rrna) gene probes in a reverse-capture checkerboard hybridization assay. species-specific polymerase chain reaction (pcr) was also performed to detect enterococcus faecalis and candida albicans. ... | 2008 | 18634922 |
| third molars and the efficacy of mechanical debridement in reducing pathogen levels in pregnant subjects: a pilot study. | to assess the impact of mechanical debridement (scaling and root planing), without adjunctive therapy, on reducing the numbers of periodontal pathogens detected in pregnant subjects with and without visible third molars. | 2008 | 18634941 |
| profile of anti-tp47 antibodies in patients with positive serology for syphilis analized by western blot. | in brazil, syphilis is still a great problem of public health. serological test is essential for syphilis diagnosis and the current trend is the use of recombinant antigen in the treponemal tests, due to its confirmed higher sensibility and specificity. the purpose of the present study was to analyze the profile of anti-tp47 antibodies in patients with positive serology for syphilis. one hundred positive sera samples were analyzed by western blot (wb) technique, using the recombinant antigen (rt ... | 2008 | 18641851 |
| sexually transmitted diseases and risk behaviors among california farmworkers: results from a population-based survey. | the prevalence of sexually transmitted diseases and associated risk behaviors among california farmworkers is not well described. | 2008 | 18643805 |
| an unusual case of acute leg weakness. | | 2008 | 18646423 |
| syphilis presenting as isolated cervical lymphadenopathy: two related cases. | two young adult brothers, with no apparent risk for sexually transmitted infections (sti), presented with unilateral cervical lymphadenitis. syphilis was diagnosed by fine-needle aspiration cytology in one case, and subsequent serology and revision of a resected lymph node in the second case. clinicians should have a high index of suspicion and a low diagnostic threshold in patients with unexplained lymphadenopathy, even in the absence of a history of primary syphilis, or obvious risk for sti. | 2009 | 18649948 |
| genome organization of treponema zioleckii. | genome analysis of treponema zioleckii proved that, in this bacterium, besides chromosomal dna, a relatively small extrachromosomal dna element is present. this element was shown to be a double-stranded circular plasmid dna of approximately 7 kbp; it was designated as pkt. the plasmid was characterized by molecular and bioinformatic analysis. no pkt homologous dna sequences were detected in other rumen treponema strains. the overall g+c content of the pkt plasmid is approximately 56 %, which is ... | 2008 | 18661302 |
| neurosyphilitic gumma in a homosexual man with hiv infection confirmed by polymerase chain reaction. | the brain gumma is a rare manifestation of the tertiary stage of syphilis. a case of neurosyphilitic gumma was confirmed by the treponema pallidum polymerase chain reaction in a 46-year-old hiv-positive homosexual man. the patient presented with a severe headache and was hospitalized. a computed tomography scan was performed which revealed a left frontal lobe mass. lymphoma was suspected. however, infectious disease diagnostics were performed on the cerebrospinal fluid that included investigatio ... | 2008 | 18663050 |
| yaws eradication: past efforts and future perspectives. | | 2008 | 18670655 |
| the return of yaws. | | 2008 | 18670660 |
| treatment outcomes of dental flossing in twins: molecular analysis of the interproximal microflora. | the purpose of this study was to assess the effects of dental flossing on the microbial composition of interproximal plaque samples in matched twins. | 2008 | 18672992 |
| sexually transmitted infections and risk factors for gonorrhea and chlamydia in female sex workers in soc trang, vietnam. | to determine the prevalence of selected stis and correlates of chlamydia (ct) and gonorrhea (gc) infection among (fsws) in soc trang province, vietnam. | 2008 | 18685547 |
| infections and autoimmune thyroid diseases: parallel detection of antibodies against pathogens with proteomic technology. | different types of infection are implicated in the pathogenesis of autoimmune thyroid diseases (aitd) through molecular mimicry or other mechanisms, but their role is disputed. human studies support direct or indirect evidence of involvement of some viral and bacterial agents, but reports have provided conflicting and inconclusive results. using a new automated multiplex array platform for the detection of antibodies, we determined seroreactivity against toxoplasma gondii, treponema pallidum, ru ... | 2008 | 18700170 |
| syphilis testing algorithms using treponemal tests for initial screening--four laboratories, new york city, 2005-2006. | in the united states, testing for syphilis traditionally has consisted of initial screening with an inexpensive nontreponemal test, then retesting reactive specimens with a more specific, and more expensive, treponemal test. when both test results are reactive, they indicate present or past infection. however, for economic reasons, some high-volume clinical laboratories have begun using automated treponemal tests, such as automated enzyme immunoassays (eias) or immunochemoluminescence tests, and ... | 2008 | 18701877 |
| the relationship between periodontal disease and preterm low birthweight: clinical and microbiological results. | findings on the effect of periodontal disease on preterm low birthweight are inconclusive. the objective of this study was to compare periodontal clinical measures and the levels and proportions of 39 bacterial species in subgingival biofilm samples in puerperal women with preterm low birthweight and nonpreterm low birthweight. | 2008 | 18702632 |
| development of a transposon mutagenesis system in the oral spirochete treponema denticola. | here, we report successful transposon mutagenesis in the oral spirochete treponema denticola. a modified himar1 transposon, including a new antibiotic selection cassette for t. denticola, generated mutations affecting cell division, transport, and chemotaxis, among other processes. this random mutagenesis system should facilitate research on the biology and pathogenesis of this spirochete, which is associated with human periodontal diseases. | 2008 | 18723655 |
| qualitative and quantitative aspects of the serological diagnosis of early syphilis. | the aim of the present study was to evaluate the use of various serological tests in the diagnosis of early syphilis. the murex enzyme immunoassay (eia) test was used for screening; the venereal diseases research laboratory (vdrl) test, the treponema pallidum particle agglutination assay (tppa) and the mercia antitreponemal igm eia were used in all the patients with a positive screening test and in those with suspected syphilis or in known contacts. in 89 cases of primary syphilis, the murex eia ... | 2008 | 18725554 |
| clinical and microbiological benefits of systemic metronidazole and amoxicillin in the treatment of smokers with chronic periodontitis: a randomized placebo-controlled study. | the aim of this study was to evaluate the clinical and microbiological effects of scaling and root planing (srp) alone or combined with metronidazole (mtz) or with mtz and amoxicillin (amx) in the treatment of smokers with chronic periodontitis. | 2008 | 18727657 |
| [evaluation of performance and false positivity of mediace rpr test that uses a chemistry autoanalyzer]. | we evaluated the performance and false positive rate of mediace rpr test (sekisui, japan), a newly introduced nontreponemal test using a chemistry autoanalyzer. | 2008 | 18728382 |
| the latex serologic test for syphilis-a new screening procedure. | a new macroscopic screening test for syphilis, the latex-sts test, is extraordinarily simple. after inactivation of the patient's serum for 30 minutes at 56 degrees c the test is performed by mixing the patient's serum with latex particles coated with cardiolipin and a protein fraction obtained from the non-pathogenic reiter strain of treponema pallidum. two to three minutes after mixing, the result of the test is observed on a ringed serologic plate. the sensitivity, specificity and reproducibi ... | 1966 | 18730020 |
| treponema pallidum in treated syphilis. | | 1970 | 18730421 |
| the spirocheta pallida (treponema pallida). | | 1906 | 18733788 |
| technic and staining of treponema pallidum. | | 1906 | 18733946 |
| molecular typing of treponema pallidum clinical strains from lisbon, portugal. | a molecular system was used to subtype portuguese treponema pallidum clinical strains isolated from both skin lesions and blood. the study with this system constitutes the first typing study in a european country. three t. pallidum subtypes were found: subtypes 14a (50%), 14d (45.2%), and 14f (4.8%). further studies are needed to better characterize the isolates involved in syphilis outbreaks. | 2008 | 18753355 |
| treponema denticola tror is a manganese- and iron-dependent transcriptional repressor. | treponema denticola harbours a genetic locus with significant homology to most of the previously characterized treponema pallidum tro operon. within this locus are five genes (troabcdr) encoding for the components of an atp-binding cassette cation-transport system (troabcd) and a dtxr-like transcriptional regulator (tror). in addition, a sigma(70)-like promoter and an 18 bp region of dyad symmetry were identified upstream of the troa start codon. this putative operator sequence demonstrated simi ... | 2008 | 18761626 |
| infectious typhlitis in chickens caused by spirochetes. | a weakly haemolytic spirochete was detected with an unabsorbed fluorescent antiserum to treponema hyodysenteriae in smears and cultures of scrapings of caecal mucosa of laying hens with diarrhoea. two groups of experimental chickens were fed a pure culture of this spirochete or homogenated intestinal contents of affected birds. both groups showed clinical signs of disease such as increased water content of faecal material and slight retardation of growth. a non-specific typhlitis which histologi ... | 1986 | 18766524 |
| [treponema pallidum and ludwig van beethoven's deafness]. | | 2008 | 18769779 |
| laboratory maintenance of treponema denticola. | this unit describes the methods, media, and equipment necessary for routine laboratory culture and handling of the anaerobic oral spirochete treponema denticola. topics discussed include nutrient requirements, recommended media formulations, and expected growth kinetics, as well as methods and equipment necessary to maintain anaerobic conditions. an additional protocol on isolation of t. denticola from clinical samples is included. | 2005 | 18770551 |
| genetic manipulation of treponema denticola. | the oral anaerobic spirochete, treponema denticola, has been implicated in the etiology of human periodontal diseases; however, the molecular basis for the virulence of these organisms is still unclear. potential pathogenic factors expressed by t. denticola have recently begun to be identified through the development of gene transfer approaches in this organism following electroporetic transformation. several antibiotic resistance markers have been developed for use in the construction of monosp ... | 2005 | 18770552 |
| isolation and laboratory maintenance of treponema pallidum. | the spirochetal bacteria that cause syphilis, yaws, and bejel cannot be cultivated in vitro. this unit describes methods for the isolation of subspecies of treponema pallidum and other pathogenic treponemes from clinical specimens, the propagation of these isolates in rabbits, isolation of clonal populations of t. pallidum, and techniques for maintenance of frozen stocks of these treponemes. | 2007 | 18770607 |
| photodynamic therapy as an adjunct to non-surgical periodontal treatment: a randomized, controlled clinical trial. | recent preclinical and clinical data have suggested a potential benefit of photodynamic therapy (pdt) in the treatment of periodontitis. however, there are very limited data from controlled clinical trials evaluating the effect of pdt in the treatment of periodontitis. the aim of this study was to evaluate the clinical and microbiologic effects of the adjunctive use of pdt to non-surgical periodontal treatment. | 2008 | 18771363 |
| identification of a methioninase inhibitor, myrsinoic acid b, from myrsine seguinii lév., and its inhibitory activities. | a methioninase inhibitor from myrsine seguinii was purified and identified as myrsinoic acid b. its inhibitory activities as to crude methioninase from periodontal bacteria such as fusobacterium nucleatum, porphyromonas gingivalis, and treponema denticola were determined. the ic50 values were 10.5, 82.4, and 30.3 microm respectively. | 2008 | 18776663 |
| [study on the status of syphilis infection and its influence factors on pregnant women in shenzhen]. | through questionnaire and screening, epidemiology of syphilis in pregnant women and related risk factors were studied, to develop effective policy and reducing the negative impact of the disease. | 2008 | 18785472 |
| the architect syphilis assay for antibodies to treponema pallidum: an automated screening assay with high sensitivity in primary syphilis. | to determine the sensitivity and specificity of the architect syphilis chemiluminescence assay (clia): a new highly automated screening test for syphilis. | 2009 | 18790859 |
| skin homing of treponema pallidum in early syphilis: an immunohistochemical study. | the incidence of syphilis is increasing in most parts of the world including some major european cities. the lesions developing during secondary syphilis may be difficult to diagnose clinically. similarly, the histopathologic changes do not always fulfill the typical diagnostic criteria. the objective of this study was to assess the contribution of immunohistochemistry for the identification and localization of treponema pallidum on the skin. we retrieved from our files 12 paraffin-embedded biop ... | 2009 | 18800002 |
| persisting atypical and cystic forms of borrelia burgdorferi and local inflammation in lyme neuroborreliosis. | the long latent stage seen in syphilis, followed by chronic central nervous system infection and inflammation, can be explained by the persistence of atypical cystic and granular forms of treponema pallidum. we investigated whether a similar situation may occur in lyme neuroborreliosis. | 2008 | 18817547 |
| reactivity in the venereal diseases research laboratory test and the mercia igm enzyme immunoassay after treatment of early syphilis. | the aim of the study was to compare reactivity in the mercia immunoglobulin m enzyme immunoassay (igm eia) and the venereal disease research laboratory (vdrl) after treatment of 229 previously untreated patients with early syphilis. at three months, the vdrl and the igm eia were negative in 41 (38%) and 71 (62%) cases, respectively; a four-fold or greater decrease in vdrl titre occurred in 106 (99%). at six months, the vdrl and the igm eia were negative in 45 (48%) and 69 (71%) patients, respect ... | 2008 | 18824622 |
| composition of supra- and subgingival biofilm of subjects with healthy and diseased implants. | the purpose of this study was to compare the microbial composition of supra- and subgingival biofilm in subjects with and without peri-implantitis. | 2008 | 18828812 |
| periodontal bacterial profiles in pregnant women: response to treatment and associations with birth outcomes in the obstetrics and periodontal therapy (opt) study. | a recent clinical trial (obstetrics and periodontal therapy [opt] study) demonstrated that periodontal therapy during pregnancy improved periodontal outcomes but failed to impact preterm birth. the present study evaluated seven target bacteria, aggregatibacter actinomycetemcomitans (previously actinobacillus actinomycetemcomitans), porphyromonas gingivalis, treponema denticola, tannerella forsythia (previously t. forsythensis), prevotella intermedia, campylobacter rectus, and fusobacterium nucle ... | 2008 | 18834241 |
| moxifloxacin as an adjunctive antibiotic in the treatment of severe chronic periodontitis. | the impact of moxifloxacin (mox) was analyzed in the treatment of severe chronic periodontitis. | 2008 | 18834244 |
| antenatal syphilis serology in pregnant women and follow-up of their infants in northern italy. | positive syphilis serology was noted in 119 (0.49%) of the 24 053 pregnant women delivering at st orsola hospital in bologna, italy, from november 2000 through july 2007. six presumptive cases of congenital syphilis with igm western blot positive results were found. two infants had a positive cerebrospinal fluid (csf) venereal disease research laboratory test result (one also had a positive csf pcr result), another presented long-bone lesions, and the remaining three were preterm. these observat ... | 2008 | 18834451 |
| biotransformation of 2,4,6-trinitrotoluene by pure culture ruminal bacteria. | twenty-one ruminal bacteria species were tested for their ability to degrade 2,4,6-trinitrotoluene (tnt) within 24 h. butyrivibrio fibrisolvens, fibrobacter succinogenes, lactobacillus vitulinus, selenomonas ruminantium, streptococcus caprinus, and succinivibrio dextrinosolvens were able to completely degrade 100 mg/l tnt, with <5% of the original tnt recovered as diaminonitrotoluene metabolites. eubacterium ruminantium, lactobacillus ruminis, ruminobacter amylophilus, streptococcus bovis, and w ... | 2009 | 18839246 |
| [clinical analysis on syphilis with sensorineural deafness]. | to investigate the clinical presentation, diagnosis and therapy of syphilis with sensorineural deafness. | 2008 | 18839875 |
| granulocyte chemotactic protein 2 (gcp-2/cxcl6) complements interleukin-8 in periodontal disease. | mucosal inflammatory responses are orchestrated largely by pro-inflammatory chemokines. the chemokine granulocyte chemotactic protein 2 (cxcl6) is involved in neutrophil recruitment and migration. previous studies have shown that granulocyte chemotactic protein 2 is up-regulated during mucosal inflammation (e.g. in inflammatory bowel disease), similarly to the functionally and structurally related chemokine interleukin-8. nevertheless, unlike interleukin-8, a role of granulocyte chemotactic prot ... | 2009 | 18842116 |
| neurosyphilis with mesiotemporal magnetic resonance imaging abnormalities. | we describe a patient with mesial temporal t2-weighted image hyperintensity on magnetic resonance imaging that mimicked paraneoplastic limbic encephalitis. the patient showed pupillary abnormalities suggestive of a diagnosis of neurosyphilis, and the diagnosis was supported by the results of a serum treponema pallidum hemagglutination assay (tpha) and cerebrospinal fluid examination. making a diagnosis of neurosyphilis is occasionally difficult because of the variety of clinical and imaging find ... | 2008 | 18854635 |
| [not available]. | | 1948 | 18866833 |
| factors affecting the survival of treponema pallidum in vitro. | | 1948 | 18872703 |
| phenomena of disease in rabbits fed cholesterol and infected with treponema pallidum; a progress report. | | 1948 | 18876790 |
| the nutritional requirements of treponemata; arginine, acetic acid, sulfur-containing compounds, and serum albumin as essential growth-promoting factors for the reiter treponeme. | | 1948 | 18876849 |
| [not available]. | | 1948 | 18880587 |
| syphilitic gumma of the aortic ring and left ventricle, and aneurysm of the sinus of valsalva, with demonstration of treponema pallida. | | 1948 | 18881501 |
| [not available]. | | 1948 | 18882208 |
| factors affecting the survival of treponema pallidum in vitro. | | 1948 | 18884297 |
| the serologic relationships between five cultured strains of supposed t. pallidum (noguchi, kroó, nichols, reiter and kazan) and two strains of mouth treponemata. | | 1948 | 18886533 |
| on the resistance of treponema pallidum. | | 1948 | 18892001 |
| the action of bacitracin and subtilin on treponema pallidum in vitro and in vivo. | | 1948 | 18902257 |
| [not available]. | | 1947 | 18903799 |
| a study of the nutritional requirements of the reiter strain of treponema pallidum. | | 1948 | 18917624 |
| a search for treponema pallidum in the lymph nodes of the syphilitic mouse. | | 1947 | 18921772 |
| epidemiological surveillance of syphilis patients in colentina hospital (bucharest, romania). | syphilis remains a global health problem with an estimated 12 million people infected each year. in romania a decrease in the syphilis prevalence can be observed. from 2002 (12,702 cases) and 2003 (9,698 cases) until 2006 (5,657 syphilis cases) the reduction can be explained through the intensified efforts of the ministry of pubic health to fight sti. the decrease is probably not related to an improvement of the general health status and not a consequence of some epidemiological prevention and c ... | 2007 | 18928067 |
| a case of gastric syphilis with neurosyphilis presented as epigastric pain. | gastric syphilis has non-specific symptoms and various endoscopic and radiographic findings. spirochetes are seen infrequently in biopsy specimens and the pathological findings are often non-specific. so it is very difficult to make a definitive diagnosis of gastric syphilis based on clinical symptoms and biopsy findings. we report the case of a gastric syphilis with neurosyphilis presented with epigastric pain. this case reminds us that gastric syphilis is one possibility in ulcerative gastric ... | 2008 | 18931280 |
| viability of treponema pallidum. | | 1947 | 18935610 |
| isolation and characterization of treponema phagedenis-like spirochetes from digital dermatitis lesions in swedish dairy cattle. | digital dermatitis in cattle is an emerging infectious disease. ulcerative lesions are typically located on the plantar skin between the heel bulbs and adjacent to the coronet. spirochetes of the genus treponema are found in high numbers in the lesions and are likely to be involved in the pathogenesis. the aim of this study was to obtain pure cultures of spirochetes from cattle with digital dermatitis and to describe them further. | 2008 | 18937826 |
| bilateral optic neuritis as initial manifestation of neurosyphilis in a hiv-positive patient. | syphilis, a disease which used to be terminal up to the 1950s, has become curable with the discovery of penicillin. in the last few years, an increase in its incidence has been recorded in the world as well as in croatia, primarily with the human immunodeficiency virus (hiv) co-infection. we present a 40-year-old male patient who complained of a sudden decrease of visual acuity on both eyes, accompanied by dizziness. clinical examination revealed low visual acuity and blurred edges of the optica ... | 2008 | 18949905 |
| treponema denticola does not induce production of common innate immune mediators from primary gingival epithelial cells. | it has been hypothesized that the neutrophil chemoattractant interleukin-8 (il-8) forms a gradient in the oral cavity, with the highest concentration of il-8 produced closest to the bacterial biofilm. in periodontitis, this gradient is disrupted, impairing neutrophil chemotaxis to diseased sites. treponema denticola is prominently associated with periodontal disease, yet little is known about its ability to modulate the production of inflammatory mediators by epithelial cells. others have shown ... | 2008 | 18954353 |
| high incidence of asymptomatic syphilis in hiv-infected msm justifies routine screening. | recently, the incidence of syphilis has risen, mainly among men having sex with men (msm), many of whom are coinfected with hiv. current guidelines recommend at least yearly syphilis testing in this group. in this study, we assessed the yield of routine syphilis screening in outpatient hiv-patients. | 2009 | 18971797 |
| treponema denticola peptidoglycan induces the production of inflammatory mediators and matrix metalloproteinase 9 in macrophage-like cells. | treponema denticola is a key pathogen associated with periodontitis, a chronic inflammatory disease affecting tooth-supporting tissues. in the present study, we investigated the response of human macrophage-like cells to stimulation by peptidoglycan isolated from t. denticola. we also studied the effect of the peptidoglycan preparation on the phosphorylation state of kinases. | 2009 | 18973520 |
| factors affecting human supragingival biofilm composition. i. plaque mass. | little is known about the factors that affect the microbial composition of supragingival biofilms. this study was designed to examine the relationship between total dna probe counts of supragingival biofilm samples, clinical parameters and supragingival biofilm composition. | 2009 | 18973540 |
| [item no 95: sexually transmitted diseases: primary and secondary syphilis]. | | 2008 | 18984231 |
| free soluble receptor activator of nuclear factor-kappab ligand in gingival crevicular fluid correlates with distinct pathogens in periodontitis patients. | the aim of the experiment was to investigate the levels of free soluble receptor activator of nuclear factor-kb ligand (srankl) in periodontal health and disease and their correlations to clinical parameters and important periodontal pathogens. | 2008 | 18988315 |
| emerging syphilitic optic neuropathy: critical review and recommendations. | infection with treponema pallidum causes multiorgan manifestations including isolated optic nerve involvement at any stage of the disease. this is of particular interest for resulting in severe visual impairment, which is reversible if treated adequately. | 2008 | 18997306 |
| audit of laboratory diagnostic methods for syphilis in england and wales. | the number of cases of infectious syphilis is increasing rapidly across england and wales. concern has been expressed about diagnostic delay and its potential impact on patient care. a standard operating procedure for the serological diagnosis of syphilis has recently been developed by the health protection agency. this study aimed to audit clinical and laboratory practice in england and wales against this standard. | 2009 | 19004864 |
| immune response and alveolar bone resorption in a mouse model of treponema denticola infection. | treponema denticola is considered to be an agent strongly associated with periodontal disease. the lack of an animal infection model has hampered the understanding of t. denticola pathogenesis and the host's immune response to infection. in this study, we have established an oral infection model in mice, demonstrating that infection by oral inoculation is feasible. the presence of t. denticola in the oral cavities of the animals was confirmed by pcr. mice given t. denticola developed a specific ... | 2009 | 19015247 |
| detection of helicobacter pylori dna in the saliva of patients complaining of halitosis. | helicobacter pylori infection, which causes peptic ulcers and gastric cancer, is considered a possible cause of halitosis. recently, the oral cavity was identified as a possible h. pylori reservoir, particularly in the presence of periodontal disease, which is a cause of halitosis. the purpose of this study was to evaluate by pcr the prevalence of oral h. pylori in the saliva of subjects complaining of halitosis. samples were obtained from 326 non-dyspeptic subjects, comprising 251 subjects with ... | 2008 | 19018029 |
| [relationship of putative periodontopathogenic bacteria and drug-induced gingival overgrowth]. | to investigate the effect of putative periodontopathogenic bacteria on the development of drug-induced gingival overgrowth (go) in renal transplant recipients. | 2008 | 19031785 |
| nodal inflammatory pseudotumor caused by luetic infection. | inflammatory pseudotumor of lymph nodes (ipt-ln) represents an unusual cause of lymphadenitis of unknown etiology. upon the observation of a case of ipt-ln associated with treponema pallidum (tp) infection, we analyzed a series of 9 ipt-ln and 9 extranodal ipt (spleen, 4 cases; lung, orbit, gut, skin, and liver) for the presence of tp, using a polyclonal antibody anti-tp. at the time of biopsy, none of the patients was suspected for luetic infection, nor specific serologic tests were available. ... | 2009 | 19033867 |
| vitreitis and movement disorder associated with neurosyphilis and human immunodeficiency virus (hiv) infection: case report. | in this report, we describe an unusual patient with a choreiform movement disorder, misdiagnosed as huntington disease, who later developed dense vitreitis leading to the identification of treponema pallidum as the underlying pathogen of both abnormalities. | 2008 | 19039470 |
| low seroprevalence of hiv and syphilis in pregnant women in refugee camps on the thai-burma border. | summary: refugee and migrant populations are considered to be at high risk from sexually transmitted infection (sti) and hiv. cross-sectional surveys for syphilis and hiv were conducted in antenatal clinics (ancs) on the thai-burmese border. in mae la refugee camp, the seroprevalence of hiv and syphilis were 0.2% (one of 500) (95% ci 0-1.1) and 0% (0 of 404) (95% ci 0-0.9) in 1997; and 0.4% (two of 500) (95% ci 0.1-1.4) and 0.4% (three of 741) (95% ci 0.1-1.2) in 2005, respectively; syphilis ser ... | 2008 | 19050214 |
| improving strategies for syphilis control in china: selective testing of sexually transmitted disease patients--too little, too late? | summary: syphilis testing guidelines in china are usually based on symptomatic criteria, overlooking risk assessment and ultimately opportunities for disease detection and control. we used data from 10,695 sexually transmitted disease (std) clinic patients in guangxi, china, to assess the efficacy of a potential screening tool inquiring about behavioural and health risk factors in identifying the std patients who should not be triaged for syphilis testing under current guidelines, but on the con ... | 2008 | 19050215 |
| advantages and pitfalls of the polymerase chain reaction in the diagnosis of esophageal ulcers in aids patients. | hiv-1-infected patients frequently have opportunistic esophageal infections which, when associated with severe immunodeficiency, can be attributed to unusual pathogens. the clinical presentation of several esophageal diseases is similar and the best method for a specific diagnosis of these patients has not been well defined. to evaluate the role of the polymerase chain reaction (pcr) in the etiologic definition of esophageal ulcers in hiv-1-infected patients, 96 esophageal biopsies from 79 hiv-1 ... | 2009 | 19051024 |
| persistence of extracrevicular bacterial reservoirs after treatment of aggressive periodontitis. | the purpose of this study was to test the hypothesis that periodontal pathogens associated with aggressive periodontitis persist in extracrevicular locations following scaling and root planing, systemic antibiotics, and antimicrobial rinses. | 2008 | 19053921 |
| coaggregation of treponema denticola with porphyromonas gingivalis and fusobacterium nucleatum is mediated by the major outer sheath protein of treponema denticola. | coagreggation of treponema denticola with either porphyromonas gingivalis or fusobacterium nucleatum was characterized and the role of the major outer sheath protein (msp) in the coaggregation process of these bacteria was evaluated. the msp of t. denticola was found to be able to bind to p. gingivalis and f. nucleatum cells and this binding could be inhibited by msp in a concentration-dependent manner. while sodium dodecyl sulfate polyacrylamide gel electrophoresis and periodic acid-schiff (pas ... | 2008 | 19054094 |
| treponema zioleckii sp. nov., a novel fructan-utilizing species of rumen treponemes. | during studies on fructan degradation in the rumen, a treponema-like bacterium able to utilize timothy grass fructan, commercial inulin and sucrose as the sole carbon source was recovered from sheep rumen. at least two different fructanolytic enzymes were identified in cell-free extracts of the isolated bacterium. characterization of the strain by a polyphasic approach indicated that it can be regarded as a representative of a new bacterial species within the genus treponema. electron microscopy ... | 2008 | 19054106 |
| differences in subgingival microflora of korean and german periodontal patients. | the goal of this study was to characterize the microbiological profile in samples of subgingival plaque taken from periodontal patients with different ethnic origin. | 2009 | 19058781 |