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[utilization of a solid nutrient medium for the serological method of detecting the causative agent of typhoid in patients' feces].the causative agent of typhoid fever can be revealed in feces of patients not only by the bacteriological, but also by the serological method, if the material is preliminarily grown on hard nutrient media; ploskirev's medium proved to be the optimal. it is suggested that microbial cultures left on the ager in petri dishes after the bacteriological study should be used for bacteriological analysis. in a number of cases it was possible to reveal the causative agent of typhoid fever in feces by the ...19751106092
[some problems of nomenclature and taxonomy of the enterobacteriaceae]. 19751106093
[effects of thymectomy on the natural bactericidal power of thymectomized mice].t and b-dependent systems are correlated between themselves and with the macrophage system in eliciting the immune humoral response. not all immunogens require t-b interactions to elicit the antibody response: consequently, the problem of the limits of t-dependence, with regard to different immunogen stimulations, remains open. the comparative study of the serum antibody response in mice, thymectomized at birth and in the normal ones, inferred from the values of bactericidal activity (b.a.), det ...19751106729
ineffectiveness of vi and chemically treated endotoxins as typhoid vaccines in mice challenged with a salmonella typhosa-salmonella typhimurium hybrid.purified vi antigen, acetic anthydride-treated salmonella typhosa endotoxin, and potassium methylate-treated s. typhosa endotoxin employed as vaccines in swiss white mice failed to protect these animals against challenge with a virulent s. typhimurium hybrid expressing s. typhosa antigens.19751107227
the molecular relatedness of r factors in enterobacteria of human and animal origin.the molecular length and dna homology of r factors isolated from enterobacteria of human and animal origin have been examined. dna from plasmids of the same compatibility group, whether of human or animal origin is indistinguishable, after allowance has been made for the regions coding for different antibiotic resistances. these results indicate that there is a common pool of r factors in man and ainmals.19751107478
potential biologically active agents. ix. synthesis of n-piperidino-(morpholino)-methylisatin-3-anils.sixteen n-piperidino-(morpholino)-methylisatin-3-anils have been synthesised and evaluated for their antimicrobial activity.19751107971
[morphological characteristics of typhoid bacteria as an expression of changes in the metabolism of the culture in the process of continuous and periodic growing]. 19751108534
humoral immune response in children with measles.twenty-eight black children with complicated measles were investigated for their capacity to produce antibodies when stimulated with tab antigen. their measles antibody titres were also measured. antibody production to tab was defective, especially the "h" antibody. production of measles antibody was sometimes delayed in its appearance but subsequently reached normal levels.19751114409
effects of corticosteroids on complement and the neutrophilic polymorphonuclear leukocyte. 19751118893
[possibility of the occurrence of the shwartzman phenomenon during administration of a reacting dose of typhoid antigen through the respiratory tracts].this work is devoted to the study of possible vaccinal complications of schwartzmann's phenomenon type following subcutaneous injection to rabbits, sensitized by typhoid antigen, of a reacting dose of the same antigen through the respiratory tracts. the reacting dose of the antigen of 0.5; 1.0, 1.5 ml was injected to the rabbits in the form of a dry and liquid aerosol intratracheally intrapulmonary and subcutaneously. animals to which the reacting dose of the same antigen (0.1; 0.25; 0.5; 1.0 mg ...19751124618
[the effect of polysaccharide from typhoid bacteria on hemopoietic stem cells].a study was made of dynamics of the content of colony-forming units (cfu) in the spleen and the bone marrow of the nonirradiated f1 (cba times c57bl) mice to which polysaccharide (ps) from typhoid bacilli was administered. a method of exogenous colony formation was used in this work. a single ps administration increased the cfu count in the bone marrow (2-2 1/2 times) and in the spleen (3 times). repeated (6- and 9- time) administration of ps was not more effective than a single one. apparently ...19751125415
tolerance to the granulocyte-releasing and colony-stimulating factor elevating effects of endotoxin.injection of salmonella typhosa endotoxin into either cf1 or c57bl/6j mice leads to prompt increases in serum colony-stimulating factor (csf). repeated injections of endotoxin result in a dose-related hyporesponsiveness or tolerance to this effect. tolerance is seen after either intravenous (i.v.) or intraperitoneal (i.p.) routes of administration or challenge and occurs after one to two preinjections. cross-tolerance to heterologous endotoxin (escherichia coli) was also shown. this cross-tolera ...19751125428
[pericarditis induced by salmonella typhi]. 19751135469
[serodiagnosis of s. typhi carrier state. some aspects of methodology and interpretation of passive hemagglutination test with vi antigen]. 19751142870
earlier onset of hematopoietic differentiation after expansion of the endogenous stem cell pool. 19751144677
[surgical correction of a case of valsalva sinus aneurysm and aortic insufficiency caused by salmonella typhi (author's transl)].the authors describe a case of aneurysm of the non-coronary sinus of valsalva and aortic insufficiency caused by salmonella tiphi in a 7 year old child. the exceptional ethiology is discussed as well as the problems connected with surgical correction.19751149968
[immunologic properties and role of the low-molecular component in a preparation of s. typhi vi antigen].the author compared the serological, immunogenic and protective activity of the vi-antigen and its high- and low-molecular fractions; an interaction between these fractions in administration of their mixture to the animals was studied. the low-molecular antigen (the 2nd fraction), contained in the preparation of the vi-polysaccharide differed considerably (by properties) from the high-molecular antigen. the 2nd fraction, whose antigenic substance possessed the least immunogenic and protective ca ...19751154936
salmonella typhi meningitis. a case report and family investigations. 19751160682
[amebic liver abscess associated with salmonella typhi bacteremia]. 19751163022
waterborne typhoid fever in dade county, florida. clinical and therapeutic evaluation of 105 bacteremic patients.an extensive outbreak of waterborne typhoid fever occurred in 1973 at a migrant labor camp in dade county, florida. blood cultures from 105 of the 188 patients with proved or presumptive cases of typhoid fever grew salmonella typhi. the clinical and laboratory findings in these patients were reviewed. fever, usually with temperatures above 38.8 degrees c and of the sustained type, was a primary manifestation of disease, although a majority of the patients also complained of headache and gastroen ...19751166856
cyclic kinetics and mathematical expression of the primary immune response. cyclic kinetics of antibody-forming cells following immunization with salmonella typhi o-antigen.the kinetics of antibody-forming cells (afc) in the spleen of rats immunized with salmonella typhi o-antigen was investigated. the number of nucleated cells of spleen and blood serum antibody titres in passive haemagglutination were determined in parallel. cyclic changes in the number of antibody-forming cells were detected as three peaks on the 4th, 9th, and 13th days following immunization. the fluctuations of their number were not related to the total number of nucleated cells of spleen. the ...19751170127
chloramphenicol-resistant salmonella typhi in saigon.chloramphenicol-resistant salmonella typhi was detected in saigon in september 1971. subsequently, 163 strains of s typhi were isolated, 46 percent of which were resistant to choramphenicol by the agar-disk method. sixty-two strains were studied by the broth-dilution method; 37 percent had minimal inhibitory concentrations for chloramphenicol greater than 250mug/ml, but all strains were susceptible to 0.4mug/ml of ampicillin and to a disk of a combination of trimethoprim and sulfamethoxazole (ba ...19751172682
editorial: tracking down salmonella typhi. 19751174177
[sensitivity of salmonella typhi to chloramphenicol during the last 16 years]. 19751178943
[epidemic of chloramphenicol resistant salmonella typhi. a cultural factor involved in a mexican locality]. 19751179077
[results and prospects of a study of the bacterial carrier state in typhoid]. 19751179838
prospects of conservative treatment of typhoid bacilli carriers. 19751179867
investigation of the role of vi antibodies and antibodies of iga type in the low specific bactericidal activity of the serum in typhoid carriers.absorption of sera of typhoid carriers with vi antigen resulting in the decrease of gamma a antibodies led to a significant increase in the specific bactericidal activity of the serum. on the basis of these findings the authors discuss the origin and the cause of the low values of this activity in sera of typhoid carriers and the possible meaning of this phenomenon in the pathogenesis of typhoid carriership.19751179883
amoxycillin in the treatment of typhoid fever in children. 19751190372
pharmacodynamic action of antygen vi. 19751191811
activated macrophages release a factor which lyses malignant cells but not normal cells.when rat macrophages are activated by exposure to bacterial endotoxin they acquire the capacity to lyse sarcoma cells in tissue culture. although showing no immunological specificity this lytic effect was only detectable on malignant cells; normal cells were unaffected. this tumor-selective lytic effect is mediated by a labile supernatant product.19751194858
[characteristics of the hydrodynamic and biological properties of flagellar preparations isolated from submerged cultures of s. typhi].a study was made of the hydrodynamic and biological properties of the flagella from the s. typhi 4446 cultures, isolated by the methods of differential centrifugation, in crude condition and following depolimerization and denaturing by the action of chemical and physical agents. molecular parameters of the slow and rapid components of the flagella and subunits of the flagellin were compared. the greatest antigenic activity was possessed by the high molecular fraction of the flagella isolated in ...19751199591
[method of study of factors of the industrial environment in the heterogeneity of o- and vi-antibodies]. 19751205161
[typhoid fever due to salmonella typhi resistant to chloramphenicol. first cases in chile (author's transl)]. 19751209034
[study of the process of interaction of the causative agent with the cells of the body and with a macrophage culture in experimental typhoid infection and carrier state].experiments were conducted on 117 rabbits and cells of the macrophage cultures in vitro by the methods of clinico-laboratory, quantitative microbiological, immunological, electron microscopic and microcinematographic examination; a study was made of the interaction of the typhoid causative agent with the cells of the organism and the macrophage cultures and also of some aspects of the immune response during acute typhoid infection and carrier state. infection was modelled by the enteral, subconj ...19751210897
[antibiotic sensitivity of s. typhi cultures that have reverted from l forms isolated from the blood of patients].l-forms of bacteria were isolated in 18 out of 300 fever patients with diagnoses of typhoid-paratyphoid fever, grippe, virus respiration disease and others in the diagnostic department of an infection hospital during bacteriological tests of the blood. among the cultures tested 13 were instable and reversed to the bacterial form. the type identification showed that only 9 revertants possessed properties characteristic of the typhoid fever microbes and belonged to s. typhi. sensitivity of the typ ...19751211907
depression of immune competence by phenytoin and carbamazepine. studies in vivo and in vitro.depression of one or more parameters of cellular and/or humoral immune responses was found in 60% of general hospital patients treated with phenytoin and 47% of patients treated with carbamazepine. phenytoin-treated patients failed to manifest delayed hypersensitivity (dhs) reactions to common antigens, and to make antibody to salmonella typhi and tetanus toxoid. serum levels of iga and igm, dna synthesis in circulating leucocytes, and phytohaemagglutinin (pha) induced deoxyribonucleic acid synt ...19751212810
n-acetylmuramyl-l-alanine amidase of vi phage iii.1. a lytic enzyme was isolated from vi phage iii-induced lysate of salmonella typhi, and purified about 200-fold by chromatography on irc-50, cm-cellulose, and sephadex g-75 columns. 2. both e. coli b murein and muropeptide c6 were digested on incubation with the lytic enzyme. the main product of murein and muropeptide c6 digestion is identical with tetrapeptide ala-glu-dap-ala. the release of amino groups during digestion was not accompanied by the appearance of either reducing groups or hexosa ...19751217420
biochemical, immunochemical and immunobiological properties of a chloramphenicol-resistant salmonella typhi strain isolated in mexico.the authors have compared the biochemical, immunochemical and immunobiological properties of a chloramphenicol-resistant s. typhi strain isolated during the typhoid fever epidemic in mexico of 1972 and those of a chloramphenicol-sensitive strain (s. typhi ty2). they have found no difference in the chemical composition of the two strains. the immunobiological investigations have shown, that the chloramphenicol-resistant strain contains less vi antigen, it is less virulent on mice, and its active ...19751221675
[comparison between the way of intravenous administration of flagellin from salmonella typhosa to the margial vein in the ear and into the mesenteric superior vein. preliminary note].rabbits receiving three injections of pfa intravenously in ear, after that first treatment gave a weak antibody response, after the second one a rapid and copious increase of agglutination titre; the third injection induced a very small increase. in rabbits injected with pfa in superior mesenteric vein the first injection produced a little effect, the second induced a little effect too; the third injection performed in auricular vein, gave a substancial rapid and copious antibody response. this ...19751222072
[results of comparative studies on the biological properties of s. typhi and s. paratyphi strains for the production of vaccines]. 19751224700
[participation of the lung in capturing subcutaneously injected antigens].experiments were conducted on guinea pigs. with the aid of fluorescein-labeled antibodies it was shown that following a single or a two-fold immunization into the footpad complete typhoid antigen was revealed in the lung macrophages as soon as the first days (or after a two-fold administration-in several hours) and persisted there for 30 days. there was a tendency to concentration of the antigen-containing macrophages in the perivascular and the peribronchial tissues. the dynamics of the antigen ...19751225401
[proceedings: the efficacy testing of salmonella typhi vaccines in animal experiments]. 19751228566
[search for new salmonella typhi phage types among the numerous non-phagetypable positive vi strains (groups i + iv) of the indochinese peninsula (author's transl)]. 19751231400
[epidemiological aspects of typhoid fever in the cap bon region (tunisia)]. 19751231666
effects of high concentrations of sucrose in blood culture media with special reference to the cultivation of salmonella typhi. 19751232715
[phage typing of s.typhi in northern italy in the period of 1965-1974]. 19751233462
[a case of pregnancy and typhoid fever]. 19751235431
[effect of adjuvants on the cellular function of the monocytic phagocytosing system].the authors studied the effect of adjuvants differing by origin and physico-chemical nature (complete freund's adjuvant, s. typhi endoxin, cadmium sulfate, iron trichloride) on the ingestion and digestion of erythrocytes of the sheep by the cells of monocytic phagocytizing system, on the persistence of the antigen in these cells, its complexation with the rna-macrophages and the function of their lysosomal apparatus. the adjuvants change the phagocytizing capacity of the macrophages only in thei ...19751239149
[effect of the number of times of typhoid antigen administration on the process of antibody formation]. 19751239150
[comparative evaluation of the immunological activity of new typhoid vaccines with established prophylactic effectiveness (data from a controlled experiment)].the authors present the results of studying the immunological efficacy of a dry alcoholic typhoid vaccine enriched with s. typhi vi-antigen in the assessment of this vaccine in controlled epidemiological trial during the immunization of children aged 7--8 years. o- and vi-antibodies were tested in the reaction of hemagglutination, h-antibodies--in the agglutination reaction with the microbial diagnostic agent, the properties of antibodies--in a test with cystein, and bactericidal properties of t ...19751239151
[chemical characteristics and biological activities of lipid fractions of endotoxin]. 19751240221
[salmonella infections in upper volta (author's transl)]. 19751241479
[distribution of salmonella typhi lysotypes in iran (1970-1974)]. 19751242693
gallbladder disease in the young male.eighteen of 2,614 patients undergoing cholecystectomy in two large general hospitals were males between the ages of two and twenty years. the great majority presented with a typical symptoms of cholecystitis. ten of the eighteen had idiopathic cholelithiasis, with no predisposing factors generally associated with an increased incidence of this disease. this diagnosis must be kept in mind in dealing with patients of this age group.19761251966
diencephalic efflux of 22na+ and 45ca2+ ions in the febrile cat: effect of an antipyretic. 19761252933
oxolinic acid in the treatment of typhoid fever due to chloramphenicol-resistant strains of salmonella typhi.of 28 strains of salmonella typhosa collected in late 1972 in vietnam, 4 had minimum inhibitory concentrations to chloramphenicol of >100 mug/ml. median minimum inhibitory concentrations of all strains to oxolinic acid were 0.39 mug/ml; ampicillin, 6.25 mug/ml; amoxicillin, 0.39 mug/ml. widespread typhoid fever appeared in mid-1973 with more than three-fourths of strains found to be resistant to chloramphenicol. peak serum concentrations of oxolinic acid average 3.0 mug/ml after the oral ingesti ...19761259398
recovery of 61 salmonella serotypes from artificially contaminated turkey skin.selenite brilliant-green sulfa enrichment broth containing tween 80 was streaked to brilliant-green sulfa plates for use in comparing recoverability of 61 different salmonella serotypes from turkey tails artifically contaminated with very low levels of each serotype. recoverability was 100% with 43 of the serotypes, 80% with eight, 60% with four, and 40% or less with six.19761259660
attenuated, streptomycin-dependent salmonella typhi oral vaccine: potential deleterious effects of lyophilization.four studies were done with streptomycin-dependent salmonella typhi as an oral, attenuated vaccine. studies 1 and 3 employed freshly harvested vaccine, whereas studies 2 and 4 involved lyophilized vaccine. five to eight doses (3 x 10(10)-10(11) organisms/dose) were given; oral streptomycin (1.0 g) was administered concomitantly in studies 2 and 3, with only two of the doses of vaccine in study 1, and was not given in study 4. no adverse reactions were encountered in 179 vaccinated men, and 94% o ...19761262709
typhoid alarm on board a container ship. 19761265835
wound dehiscence after cholecystectomy and salmonella infection.a case of a wound dehiscence following a salmonella wound infection is reported. cholecystectomy for the typhoid carrier state is not an uncommon operation and carries the risk of salmonella wound infection in about 7 per cent of the cases. wound dehiscence with this type of infection has not previously been reported.19761267288
the relationship between bilharziasis and typhoid fever employing the widal test as a screening procedure. 19761268942
succinic dehydrogenase and glucose-6-phosphate dehydrogenase activities in brain of mice after administration of salmonella typhi endotoxin. 19761270104
inhibition of lethality in endotoxin-challenged mice treated with zinc chloride.zinc chloride protected against lethality in mice undergoing endotoxin shock.19761270141
[levels of antibodies to typhoid fever in vaccinated and non-vaccinated children in the course of other diseases with the exception of salmonelloses]. 19761273311
monoclonal antibodies against salmonella porins: generation and characterization.monoclonal antibodies (mabs) were generated against porins, one of the major outer membrane proteins of salmonella typhi. six clones, designated mp1, mp2, mp3 (igg2ak), mpn4, mpn6 (igg1k) and mpn5 (igg2bk) were characterized by enzyme immunoassay (elisa) for their reactivity to porins from s. typhi, salmonella paratyphi a, s. paratyphi b, s. paratyphi c, salmonella choleraesuis, salmonella enteritidis, salmonella krefeld, salmonella panama, salmonella typhimurium, escherichia coli b, shigella fl ...19921280248
a case of ciprofloxacin-resistant typhoid fever. 19921284936
[optimization of culture conditions for the production of salmonella typhi o and h antigenic suspensions].a behring's production protocol of antigenic suspensions o and h of salmonella typhi has been studied. the object of this study has been the search of optimal conditions of cultivation and their exploitation on fermentor. a fermentation using the i.p.a culture medium has been realized to compare its results with that obtained using behring's culture medium (b.c.m). the optimal cultivation conditions obtained are a waving rate of 400 tr/mn, a ph of 7.6 and an important air flow. relating to nutri ...19921285026
salmonella typhi in tower hamlets. 19921285180
the incompatibility complex of h. plasmids.this review deals with the general properties of the very large transfer thermosensitivity r. factor belonging to the h. incompatibility complex. this group is of particular interest not only because their temperature sensitivity transfer system but also for the number as well as distinctive resistance determinants being accumulate by them, and their prevalence in salmonella serotypes and in other gram-negative non-pathogenic bacteria both in man and animals.19921285372
enoxacin in the treatment of typhoid fever.enoxacin 400 mg twice daily was given orally to 40 patients who had salmonella typhi- or salmonella paratyphi-positive blood or bone marrow cultures. one patient was switched to parenteral therapy within 48 hours of study enrollment, but the remaining 39 patients were given enoxacin for 10 to 14 days. all 39 patients were cured by enoxacin, even though 23 (58.9%) strains were resistant to cotrimoxazole and 16 (41%) strains were multiply resistant to ampicillin, chloramphenicol, and cotrimoxazole ...19921286490
chloramphenicol-resistant typhoid fever: an emerging problem in oman.until recently multiply drug-resistant salmonella typhi was uncommon in the sultanate of oman. in 1990 the first isolate of chloramphenicol-resistant s. typhi from an indian expatriate was reported. in 1991, 58 cases of typhoid fever were diagnosed, of whom 19 (33%) were resistant to chloramphenicol. all patients with chloramphenicol-resistant s. typhi are either indians or omani with a history of recent travel to india. chloramphenicol may not be the appropriate blind therapy for such patients. ...19921287820
widespread occurrence of multiple drug-resistant salmonella typhi in india.sixteen multiple drug resistant strains of salmonella typhi belonging to vi-phage types e1 (14) and o (2) and isolated in southeast india in 1991 were characterized. all strains were resistant to chloramphenicol and the majority to trimethoprim and ampicillin. in all strains these resistances were encoded by plasmids of the h1 incompatibility group with molecular weights ranging from 110 to 120 megadaltons. physicians in european countries should be aware that treatment may fail if patients with ...19921295768
multi-drug resistance in salmonellae isolated from enteric fever cases at porur--a semi urban area near madras city.a total of 249 isolations of salmonella were made during 1991, of which 67.46 per cent were resistant to chloramphenicol. resistance to ampicillin, co-trimoxazole and amoxycillin was higher (82.91, 77.69, 81.42 per cent respectively). salmonella typhi was predominant agent forming 94.78 per cent and salmonella paratyphi a caused the remaining infections. 44.98 per cent of the isolations were in children. this outbreak has been discussed in the light of other reports from india.19921296946
[surveillance on viii phage typing and antimicrobial susceptibilities of s. typhi strains in guangdong province].72 s. typhi strains collected in guangdong were tested for their vi ii phage types and their antimicrobial susceptibilities. the result of vi ii phage typing showed that 62 strains could be divided into definite types. the result of antimicrobial susceptibilities showed that, as national standard reference strains, all the 72 local strains were susceptible to choloramphenical, gentamycin, neomycin and polymycin b and were of different resistance to other 14 antimicrobial agents. the resistant pr ...19921300249
[the fever reaction of the polecat mustela putorius x mustela putorius furo to a bacterial pyrogen: the hypo- and hyperthermic phases].it has been demonstrated that the ferret (mustela putorius x mustela putorius furo) responds to intramuscular injection of salmonella typhi lipopolysaccharide (30 ng/kg-100 micrograms/kg) by biphasic change in the body temperature (tb): the initial decrease in the latter is followed by hyperthermia. maximum rise in tb (1.6 +/- 0.1 degrees c) was observed after the injection of lipopolysaccharide in the highest dose. rabbit leucocytic pyrogen/interleukin-1 (1 ml from 3.5 x 10(7) peritoneal phagoc ...19921302417
imported cases of chloramphenicol resistant salmonella typhi. 19921303490
multi-resistant typhoid fever. 19921304255
multi-drug resistant salmonella. 19921304276
resistant salmonella meningitis treated with ofloxacin--a quinolone compound. 19921307368
typhoid fever, not responding to ciprofloxacin therapy. 19921307372
the changing faces of salmonellosis. 19921307527
changing profile of enteric fever--in summer-91.the clinical presentation, complications and sensitivity pattern was studied in 30 cases of enteric fever. fever was the main presenting feature in all. other associated predominant presenting feature were vomiting in 15 (50%), loose motion 9 (30%), cough 6 (20%), headache 4 (13.33%) and altered sensorium in 2 (6.66%). the various complications observed during hospital stay were myocarditis 5 (6.16%), paralytic ileus 2 (6.66%), pneumonia 1 (3.33%) and joint effusion in 2 (6.66%) cases respective ...19921307532
chloramphenicol resistance in salmonella typhi. report from bombay.chloramphenicol resistance to salmonella typhi in 1989 was 16% in hinduja hospital. from jan to june 1990, this resistance has increased to 81%. 74 strains of blood culture isolated of s typhi obtained from jan to june were subjected to antibiotic sensitivity testing by disc diffusion technique of kirby and bauer 60 strains were found to show a block resistance tochloramphenicol, ampicillin, co-trimoxazole, streptomycin, tetracycline and carbenicillin. all strains were sensitive to quinolones. r ...19921307533
multi resistant salmonella typhi from rural southern maharashtra. 19921308033
screening for listeria monocytogenes and other related species from faecal specimens at the lagos university teaching hospital, lagos.four hundred and twenty faecal specimens from patients with acute gastroenteritis and apparently healthy persons who reported at the lagos university teaching hospital (luth) between october, 1988 and may, 1989 were investigated for faecal carriage of listeria monocytogenes and other related species. of these specimens, none was positive for listeria species. however, the mannitol--fermenting listeria species now murraya grayi sub species grayi and murraya grayi sub spp. murrayi representing 0.9 ...19921308081
multidrug resistant enteric fever. 19921308516
construction of a genetically defined salmonella typhi ty2 aroa, aroc mutant for the engineering of a candidate oral typhoid-tetanus vaccine.the construction of a salmonella typhi ty2 strain harbouring defined deletions in both the aroa and aroc genes is described. these deletions have been fully defined at the molecular level by dna sequencing and have been introduced in such a way that no foreign dna remains in the s. typhi genome. this strain is attenuated in mice when given by the intraperitoneal route suspended in hog gastric mucin and is attenuated to a similar level to strains harbouring deletions in aroa or aroc alone indicat ...19921311488
[simultaneous cytomegalovirus and salmonella typhi infections in a healthy adult]. 19921313989
the fortuitous diagnosis of cholera in a two-year-old girl.we are reporting the fortuitous diagnosis of a case of cholera and the unusual failure of the commercial bacteriologic media that led to the unexpected isolation of vibrio cholerae. the case demonstrates the need for communication between the medical staff and laboratory personnel when an uncommon disease, such as cholera, is suspected. this case also alerts the clinician to the possibility of multiple enteric pathogens coinfecting a traveller.19921315232
comparative in vitro activity of enoxacin and other fluoroquinolones against multi-resistant strains of salmonella typhi.the in vitro activities of enoxacin, lomefloxacin, norfloxacin, ofloxacin, and pefloxacin against 274 strains of salmonella typhi isolated from suspected typhoid fever patients (137 multi-resistant strains and 137 strains sensitive to chloramphenicol, ampicillin and/or co-trimoxazole) were determined using disk diffusion and agar dilution techniques. in vitro, enoxacin was active against all tested strains with a mic90 and inhibition zone size against multi-resistant strains of 0.12 mg/l and 34 ...19921316257
the quinolones. an overview of their pharmacology.the fluoroquinolones represent a relatively new class of antibiotics with outstanding therapeutic potential, attributable to their broad spectrum of antimicrobial activity and favourable tissue distribution. they are highly active against most gram-negative pathogens, as well as staphylococcus aureus and coagulase-negative staphylococci. in addition, the fluoroquinolones have useful pharmacokinetic properties: they are orally active, and their lipophilicity and low degree of plasma protein bindi ...19921319865
inducible overproduction of the aspergillus nidulans pentafunctional arom protein and the type-i and -ii 3-dehydroquinases from salmonella typhi and mycobacterium tuberculosis.the aroq gene of mycobacterium tuberculosis, encoding a type-ii 3-dehydroquinase, and the arod gene of salmonella typhi, encoding a type-i 3-dehydroquinase, have been highly overexpressed in escherichia coli using the powerful trc promoter contained within the expression vector pkk233-2. the m. tuberculosis type-ii 3-dehydroquinase has been purified in bulk from overproducing strains of e. coli to greater than 95% homogeneity. the protein is extremely heat-stable, is active as a homododecamer an ...19921329726
active protection of mice against salmonella typhi by immunization with strain-specific porins.nih mice were immunized with between 2.5 and 30 micrograms of two highly purified porins, 34 kda and 36 kda, isolated from the virulent strain salmonella typhi 9,12, vi:d. of mice immunized with 10 micrograms of porins, 90% were protected against a challenge with up to 500 ld50 (50% lethal doses) of s. typhi 9,12,vi:d and only 30% protection was observed in mice immunized with the same dose of porins but challenged with the heterologous strain salmonella typhimurium. these results demonstrate th ...19921333686
[biological products and laboratory reagents dehydrated by a rapid direct vacuum desiccation method. ii. the preservation of typhoid vaccine and salmonella typhi ty2 strains by a rapid vacuum desiccation method]. 19921340256
[a study of some pathogenic factors of salmonella typhi].30 strains isolated from clinical cases and a laboratory induced r-mutant or s typhi were studied. the synthesis of colicin v, siderophores, hydroxamate and phenolate (aerobactin and enterochelin) were investigated using biological assays. all strains were positive for enterochelin but only strains 6586 and 4448 were positive for aerobactin. an 80 kd receptor for enterochelin was found in the outer membrane of strains. only strains 4448, 635 and 4693 produced colicin v. plasmid related antibioti ...19921340565
present phage types and antibiotic susceptibility of salmonellae.a total of 168 strains of salmonella were isolated in the command pathology laboratory (wc) delhi cantt during the year 1990. out of this, 143 were salmonella typhi, 17 salmonella paratyphi a, 7 salmonella typhimurium and 1 salmonella manhattan. the commonest phage type and biotype of salmonella typhi was type e1 and type 1 respectively. the dominant biotype of salmonella paratyphi a was type i. there was a very high degree of multidrug resistance of most of the strains. but all the strains were ...19921344225
mucosal immunity to oral vaccines. 19921346028
ciprofloxacin and typhoid fever. 19921347601
ciprofloxacin and typhoid fever. 19921347602
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