| evolutionary history and attenuation of myxoma virus on two continents. | the attenuation of myxoma virus (myxv) following its introduction as a biological control into the european rabbit populations of australia and europe is the canonical study of the evolution of virulence. however, the evolutionary genetics of this profound change in host-pathogen relationship is unknown. we describe the genome-scale evolution of myxv covering a range of virulence grades sampled over 49 years from the parallel australian and european epidemics, including the high-virulence progen ... | 2012 | 23055928 |
| [effects of myxoma virus on gliomas of rats models in vivo]. | to explore the in vivo effects of myxoma virus (mv) on gliomas of rat model. methods c6 glioma cells were implanted into the frontal lobe of sd rats using stereotactic methods to establish animal models of glioma. | 2012 | 23002546 |
| [study in the killing effect of myxoma virus to c6 glioma cell in vitro]. | to evaluate the susceptibility of c6 glioma cells to myxoma virus and the killing effect of myxoma virus to the c6 glioma cells in vitro. | 2012 | 22919752 |
| investigation of cytotoxicity of negative control peptides versus bioactive peptides on skin cancer and normal cells: a comparative study. | resonant recognition model-myxoma virus (rrm-mv), a bioactive peptide analogue for myxoma virus mv-t5 protein, was computationally designed by the rrm. in this study, the anticancer effects of rrm-mv were assessed in vitro against four negative control peptides on human skin cancer and normal cells. | 2012 | 22917245 |
| virotherapy using myxoma virus prevents lethal graft-versus-host disease following xeno-transplantation with primary human hematopoietic stem cells. | graft-versus-host disease (gvhd) is a potentially lethal clinical complication arising from the transfer of alloreactive t lymphocytes into immunocompromised recipients. despite conventional methods of t cell depletion, gvhd remains a major challenge in allogeneic hematopoietic cell transplant. here, we demonstrate a novel method of preventing gvhd by ex vivo treatment of primary human hematopoietic cell sources with myxoma virus, a rabbit specific poxvirus currently under development for oncoly ... | 2012 | 22905251 |
| sheeppox virus sppv14 encodes a bcl-2-like cell death inhibitor that counters a distinct set of mammalian proapoptotic proteins. | many viruses express inhibitors of programmed cell death (apoptosis), thereby countering host defenses that would otherwise rapidly clear infected cells. to counter this, viruses such as adenoviruses and herpesviruses express recognizable homologs of the mammalian prosurvival protein bcl-2. in contrast, the majority of poxviruses lack viral bcl-2 (vbcl-2) homologs that are readily identified by sequence similarities. one such virus, myxoma virus, which is the causative agent of myxomatosis, expr ... | 2012 | 22896610 |
| oncolysis of canine tumor cells by myxoma virus lacking the serp2 gene. | to determine the oncolytic efficacy of an attenuated form of myxoma virus lacking the serp2 gene in canine tumor cells. | 2012 | 22849686 |
| a bioactive peptide analogue for myxoma virus protein with a targeted cytotoxicity for human skin cancer in vitro. | cancer is an international health problem, and the search for effective treatments is still in progress. peptide therapy is focused on the development of short peptides with strong tumoricidal activity and low toxicity. in this study, we investigated the efficacy of a myxoma virus peptide analogue (rrm-mv) as a candidate for skin cancer therapy. rrm-mv was designed using the resonant recognition model (rrm) and its effect was examined on human skin cancer and normal human skin cells in vitro. | 2012 | 22805371 |
| innate immune response of human plasmacytoid dendritic cells to poxvirus infection is subverted by vaccinia e3 via its z-dna/rna binding domain. | plasmacytoid dendritic cells (pdcs) play important roles in antiviral innate immunity by producing type i interferon (ifn). in this study, we assess the immune responses of primary human pdcs to two poxviruses, vaccinia and myxoma virus. vaccinia, an orthopoxvirus, was used for immunization against smallpox, a contagious human disease with high mortality. myxoma virus, a leporipoxvirus, causes lethal disease in rabbits, but is non-pathogenic in humans. we report that myxoma virus infection of hu ... | 2012 | 22606294 |
| selective purging of human multiple myeloma cells from autologous stem cell transplantation grafts using oncolytic myxoma virus. | autologous stem cell transplantation and novel therapies have improved overall survival of patients with multiple myeloma; however, most patients relapse and eventually succumb to their disease. evidence indicates that residual cancer cells contaminate autologous grafts and may contribute to early relapses after autologous stem cell transplantation. here, we demonstrate that ex vivo treatment with an oncolytic poxvirus called myxoma virus results in specific elimination of human myeloma cells by ... | 2012 | 22516053 |
| modulation of the myxoma virus plaque phenotype by vaccinia virus protein f11. | vaccinia virus (vacv) produces large plaques consisting of a rapidly expanding ring of infected cells surrounding a lytic core, whereas myxoma virus (myxv) produces small plaques that resemble a focus of transformed cells. this is odd, because bioinformatics suggests that myxv carries homologs of nearly all of the genes regulating orthopoxvirus attachment, entry, and exit. so why does myxv produce foci? one notable difference is that myxv-infected cells produce few of the actin microfilaments th ... | 2012 | 22514354 |
| targeting pediatric cancer stem cells with oncolytic virotherapy. | cancer stem cells (cscs), also termed "cancer-initiating cells" or "cancer progenitor cells," which have the ability to self-renew, proliferate, and maintain the neoplastic clone, have recently been discovered in a wide variety of pediatric tumors. these cscs are thought to be responsible for tumorigenesis and tumor maintenance, aggressiveness, and recurrence due to inherent resistance to current treatment modalities such as chemotherapy and radiation. oncolytic virotherapy offers a novel, targe ... | 2012 | 22430386 |
| myxoma virus m064 is a novel member of the poxvirus c7l superfamily of host range factors that controls the kinetics of myxomatosis in european rabbits. | the myxoma virus (myxv) carries three tandem c7l-like host range genes (m062r, m063r, and m064r). however, despite the fact that the sequences of these three genes are similar, they possess very distinctive functions in vivo. the role of m064 in myxv pathogenesis was investigated and compared to the roles of m062 and m063. we report that m064 is a virulence factor that contributes to myxv pathogenesis but lacks the host range properties associated with m062 and m063. | 2012 | 22379095 |
| development and validation of a myxoma virus real-time polymerase chain reaction assay. | to aid in the rapid diagnosis of myxomatosis in rabbits, a real-time polymerase chain reaction (pcr) for the specific detection of myxoma virus is described. primers and probe were designed to amplify a 147-bp fragment within the serp2 gene. the assay was able to detect 23 copies of a synthesized oligo indicating a reliable sensitivity. in addition, the real-time pcr did not detect the rabbit fibroma virus used in myxomatosis vaccines. the novel pcr was shown to be able to detect myxoma virus in ... | 2012 | 22362943 |
| acute myeloid leukemia targeting by myxoma virus in vivo depends on cell binding but not permissiveness to infection in vitro. | some oncolytic viruses, such as myxoma virus (myxv), can selectively target malignant hematopoietic cells, while sparing normal hematopoietic cells. this capacity for discrimination creates an opportunity to use oncolytic viruses as ex vivo purging agents of autologous hematopoietic cell grafts in patients with hematologic malignancies. however, the mechanisms by which oncolytic viruses select malignant hematopoietic cells are poorly understood. in this study, we investigated how myxv specifical ... | 2012 | 22341701 |
| myxomatosis in australia and europe: a model for emerging infectious diseases. | myxoma virus is a poxvirus naturally found in two american leporid (rabbit) species (sylvilagus brasiliensis and sylvilagus bachmani) in which it causes an innocuous localised cutaneous fibroma. however, in european rabbits (oryctolagus cuniculus) the same virus causes the lethal disseminated disease myxomatosis. the introduction of myxoma virus into the european rabbit population in australia in 1950 initiated the best known example of what happens when a novel pathogen jumps into a completely ... | 2012 | 22333483 |
| novel bivalent vectored vaccine for control of myxomatosis and rabbit haemorrhagic disease. | a novel, recombinant myxoma virus-rabbit haemorrhagic disease virus (rhdv) vaccine has been developed for the prevention of myxomatosis and rabbit haemorrhagic disease (rhd). a number of laboratory studies are described illustrating the safety and efficacy of the vaccine following subcutaneous administration in laboratory rabbits from four weeks of age onwards. in these studies, both vaccinated and unvaccinated control rabbits were challenged using pathogenic strains of rhd and myxoma viruses, a ... | 2012 | 22266680 |
| why do parasites harm their host? on the origin and legacy of theobald smith's "law of declining virulence"--1900-1980. | why do parasites harm their host? the persistence of this question in the history of the life sciences rests partly on a seeming biological paradox. in effect, although the annihilation of the host by a parasite could be depicted as a crude example of "the survival of the fittest," situations where the host dies rapidly often amount to a pyrrhic victory because parasitic colonies harboured within it may die as well before the transmission stage. so why would natural selection favour high virulen ... | 2012 | 23607167 |
| systemic virotherapy for multiple myeloma. | the multiple myeloma (mm) treatment scenario has changed considerably over the past few years. several novel targeted therapies are currently under consideration including oncolytic virotherapy. areas covered: this review provides an analysis of the mechanisms of action of virotherapy, and summarizes the preclinical and clinical studies of systemic virotherapy developed for the treatment of mm. different types of viruses have been identified, including: adenovirus, vaccinia virus, herpes simplex ... | 2017 | 28796556 |
| poxviruses utilize multiple strategies to inhibit apoptosis. | cells have multiple means to induce apoptosis in response to viral infection. poxviruses must prevent activation of cellular apoptosis to ensure successful replication. these viruses devote a substantial portion of their genome to immune evasion. many of these immune evasion products expressed during infection antagonize cellular apoptotic pathways. poxvirus products target multiple points in both the extrinsic and intrinsic apoptotic pathways, thereby mitigating apoptosis during infection. inte ... | 2017 | 28786952 |
| next step in the ongoing arms race between myxoma virus and wild rabbits in australia is a novel disease phenotype. | in host-pathogen arms races, increases in host resistance prompt counteradaptation by pathogens, but the nature of that counteradaptation is seldom directly observed outside of laboratory models. the best-documented field example is the coevolution of myxoma virus (myxv) in european rabbits. to understand how myxv in australia has continued to evolve in wild rabbits under intense selection for genetic resistance to myxomatosis, we compared the phenotypes of the progenitor myxv and viral isolates ... | 2017 | 28808019 |
| reverse engineering field isolates of myxoma virus demonstrates that some gene disruptions or loss of function do not explain virulence changes observed in the field. | the coevolution of myxoma virus (myxv) and wild european rabbits in australia and europe is a paradigm for the evolution of a pathogen in a new host species. genomic analyses have identified the mutations that have characterized this evolutionary process, but defining causal mutations in the pathways from virulence to attenuation and back to virulence has not been possible. using reverse genetics we examined the role of six selected mutations found in australian field isolates of myxv that fall ... | 2017 | 28768866 |
| apoptosis-inducing effect of myxoma virus on human neuroglioma cell lines. | the purpose of this study was to further evaluate the role of myxoma virus (myxv) as an oncolytic agent against experimental human gliomas in vitro, and analyze the effect of myxv on malignant glioma cells at different incubation periods and infected at different multiplicities of infection. neuroglioma cell lines u251 and a172 were cultured with various infective doses of myxoma virus at different time points (0-3 days) and cellular survival rates were evaluated using an mtt assay. cell viabili ... | 2017 | 28672936 |
| large-scale assessment of myxomatosis prevalence in european wild rabbits (oryctolagus cuniculus) 60years after first outbreak in spain. | myxomatosis is a viral disease that affects european rabbits (oryctolagus cuniculus) worldwide. in spain, populations of wild rabbits drastically decreased in the 1950s after the first outbreak of myxomatosis. since that first appearance, it seems to be an annual epizootic in spain with periodic outbreaks, predominantly in summer and autumn. taking into account rabbit population structure, abundance, and genetic lineage, this paper attempts to make a large-scale characterization of myxomatosis s ... | 2017 | 28558359 |
| in vivo and in situ programming of tumor immunity by combining oncolytics and pd-1 immune checkpoint blockade. | blockade of the programmed cell death protein 1 (pd1) pathway is clinically effective against human cancers. although multiple types of malignancies have been shown to respond to pd1 agents, only a small percentage of patients typically benefit from this treatment. in addition, pd1 therapy often causes serious immune-related adverse events. a recent study demonstrated that local, intra-tumoral, administration of modified oncolytic myxoma virus which expresses a truncated version of the pd1 prote ... | 2017 | 28546884 |
| detection of rabbit haemorrhagic disease virus 2 during the wild rabbit (oryctolagus cuniculus) eradication from the berlengas archipelago, portugal. | in the regular wildlife monitoring action carried out in the summer of the past few years at the berlenga island, wild rabbits (oryctolagus cuniculus) have been repeatedly found dead. however, the origin of those deaths was never investigated. our aim was to investigate the cause of death of 11 rabbits collected between april and may 2016. | 2017 | 29141631 |
| viruses for landscape-scale therapy: biological control of rabbits in australia. | viral diseases, whether of animals or humans, are normally considered as problems to be managed. however, in australia, two viruses have been used as landscape-scale therapeutics to control european rabbits (oryctolagus cuniculus), the preeminent invasive vertebrate pest species. rabbits have caused major environmental and agricultural losses and contributed to extinction of native species. it was not until the introduction of myxoma virus that effective control of this pest was obtained at a co ... | 2021 | 33108654 |
| molecular detection of myxoma virus in the environment of vaccinated rabbitries. | myxoma virus (myxv) is the aetiological agent of myxomatosis, a systemic, mostly lethal disease that affects european rabbits. vaccination against it, although widespread, has not been completely effective and disease outbreaks still take place on farms which carry out vaccination programmes. since some of these cases have been attributed to airborne transmission or the spread of the virus via inanimate vectors, the aims of this study were to determine myxv contamination levels and distribution ... | 2020 | 32813890 |
| detection of myxoma virus dna in ticks from lagomorph species in spain suggests their possible role as competent vector in viral transmission. | myxoma virus (myxv) causes morbidity and mortality in european wild rabbits (oryctolagus cuniculus) worldwide, and recently in iberian hares (lepus granatensis) in spain. we aimed to assess the presence of myxv-specific dna in ixodid ticks collected from both hosts. a total of 417 ticks harvested from 30 wild lagomorphs, including wild rabbits and iberian hares were collected from southern spain. enzyme-linked immunosorbent assay and pcr-sequencing were used to detect virus exposure and presence ... | 2021 | 33626569 |
| a versatile qpcr for diagnosis of leporid gammaherpesvirus 5 using evagreen® or taqman® technologies. | in late 2019, the first herpesvirus in the genus lepus, named leporid gammaherpesvirus 5 (lehv-5) was described. at the time, herpetic typical lesions were observed in hares infected by the myxoma virus, which is known to induce immunosuppression. though the real impact of lehv-5 is still poorly understood, since it affects reproduction, it poses an additional threat to the already fragile populations of iberian hare, demanding prevalence investigations. in this article, we describe the first qu ... | 2021 | 33924254 |
| biological characteristics and permissiveness to viruses of diploid kidney cells strain from the bat nathusius' pipistrelle (pipistrellus nathusii keyserling & blasius, 1839; chiroptera: microchiroptera: vespertilionidae). | bats are an epidemiologically important natural reservoir of viruses of various taxonomic groups, including causative agents of especially dangerous infections of humans and animals. considering the relevance of arbovirus infections, it seems advisable to study the spectrum of the sensitivity of cells derived from bats inhabiting and migrating on the territory of the russian federation to causative agents of vector-borne diseases of animals.the study aimed to obtain a diploid strain of cells fro ... | 2021 | 33683063 |
| a potential atypical case of rabbit haemorrhagic disease in a dwarf rabbit. | rabbit haemorrhagic disease (rhd) is a highly contagious infectious disease of european wild and domestic rabbits. rabbit haemorrhagic disease virus (rhdv, gi.1) emerged in 1986 in europe, rapidly spreading all over the world. several genotypes of rhdv have been recognised over time, but in 2010, a new virus (rhdv2/rhdvb, gi.2) emerged and progressively replaced the previous rhdv strains, due to the lack of cross-immunity conferred between rhdv and rhdv2. rhdv2 has a high mutation rate, similarl ... | 2020 | 33379183 |
| genomic insights into a population of introduced european rabbits oryctolagus cuniculus in australia and the development of genetic resistance to rabbit hemorrhagic disease virus. | the european rabbit (oryctolagus cuniculus) is one of the most devastating invasive species in australia. since the 1950s, myxoma virus (myxv) and rabbit haemorrhagic disease virus (rhdv) have been used to manage overabundant rabbit populations. resistance to myxv was observed within a few years of the release. more recently, resistance to lethal rhdv infection has also been reported, undermining the efficiency of landscape-scale rabbit control. previous studies suggest that genetic resistance t ... | 2021 | 33560563 |
| coinfections of novel polyomavirus, anelloviruses and a recombinant strain of myxoma virus-myxv-tol identified in iberian hares. | viruses are ubiquitous in nature; however, very few have been identified in the leporid species. in the fall of 2018, an outbreak of myxomatosis in iberian hares (lepus granatensis) was reported in spain and a novel recombinant myxoma virus strain (myxv-tol) was identified. to investigate variability within the recombinant region of the myxv-tol and identify any potential viral coinfections, samples (ear, eyelid or vaginal) of iberian hares were collected from spain and analyzed. the presence of ... | 2020 | 32244962 |
| variable changes in nematode infection prevalence and intensity after rabbit haemorrhagic disease virus emerged in wild rabbits in scotland and new zealand. | the myxoma virus (a microparasite) reduced wild rabbit numbers worldwide when introduced in the 1950s, and is known to interact with co-infecting helminths (macroparasites) causing both increases and decreases in macroparasite population size. in the 1990s rabbit haemorrhagic disease virus (rhdv) infected rabbits and also significantly reduced rabbit numbers in several countries. however, not much is known about rhdv interactions with macroparasites. in this study, we compare prevalence and inte ... | 2018 | 29892555 |
| refinement and successful implementation of a scoring system for myxomatosis in a susceptible rabbit (oryctolagus cuniculus) model. | myxoma virus is a member of leporipoxviridae whose tropism is tightly restricted to lagomorphs. in susceptible oryctolagus rabbits, the virus causes a highly lethal disease known as myxomatosis, which begins as a localized infection but rapidly disseminates throughout the animal, leading to immune compromise, mucosal infections, multiorgan failure, and death. in a research setting, myxoma infection of susceptible oryctolagus cuniculus rabbits is used as a model of poxviral disease progression an ... | 2018 | 30017020 |
| disentangling synergistic disease dynamics: implications for the viral biocontrol of rabbits. | european rabbits (oryctolagus cuniculus) have been exposed to rabbit haemorrhagic disease virus (rhdv) and myxoma virus (myxv) in their native and invasive ranges for decades. yet, the long-term effects of these viruses on rabbit population dynamics remain poorly understood. in this context, we analysed 17 years of detailed capture-mark-recapture data (2000-2016) from turretfield, south australia, using a probabilistic state-space hierarchical modelling framework to estimate rabbit survival and ... | 2018 | 30133819 |
| punctuated evolution of myxoma virus: rapid and disjunct evolution of a recent viral lineage in australia. | myxoma virus (myxv) has been evolving in a novel host species-european rabbits-in australia since 1950. previous studies of viruses sampled from 1950 to 1999 revealed a remarkably clock-like evolutionary process across all australian lineages of myxv. through an analysis of 49 newly generated myxv genome sequences isolated in australia between 2008 and 2017, we show that myxv evolution in australia can be characterized by three lineages, one of which exhibited a greatly elevated rate of evolutio ... | 2019 | 30728252 |
| parallel adaptation of rabbit populations to myxoma virus. | in the 1950s the myxoma virus was released into european rabbit populations in australia and europe, decimating populations and resulting in the rapid evolution of resistance. we investigated the genetic basis of resistance by comparing the exomes of rabbits collected before and after the pandemic. we found a strong pattern of parallel evolution, with selection on standing genetic variation favoring the same alleles in australia, france, and the united kingdom. many of these changes occurred in ... | 2019 | 30765607 |
| myxoma virus jumps species to the iberian hare. | the study of myxoma virus (myxv) infections in the european rabbit (oryctolagus cuniculus) has produced one of the most accepted host-pathogen evolutionary models. to date, myxomatosis has been limited to the european rabbit with sporadic reports in hares. however, reports of widespread mortalities in the iberian hare (lepus granatensis) with myxomatosis-like clinical signs indicate a potential species jump has occurred. the presence of myxv dna was confirmed by pcr in 244 samples received from ... | 2019 | 31322320 |
| comparative analysis of rna virome composition in rabbits and associated ectoparasites. | ectoparasites play an important role in virus transmission among vertebrates. little, however, is known about the nature of those viruses that pass between invertebrates and vertebrates. in australia, flies and fleas support the mechanical transmission of two viral biological controls against wild rabbits-rabbit hemorrhagic disease virus (rhdv) and myxoma virus. we compared virome compositions in rabbits and these ectoparasites, sequencing total rna from multiple tissues and gut contents of wild ... | 2020 | 32188733 |
| myxoma virus-encoded host range protein m029: a multifunctional antagonist targeting multiple host antiviral and innate immune pathways. | myxoma virus (myxv) is the prototypic member of the leporipoxvirus genus of the poxviridae family of viruses. in nature, myxv is highly restricted to leporids and causes a lethal disease called myxomatosis only in european rabbits (oryctologous cuniculus). however, myxv has been shown to also productively infect various types of nonrabbit transformed and cancer cells in vitro and in vivo, whereas their normal somatic cell counterparts undergo abortive infections. this selective tropism of myxv f ... | 2020 | 32456120 |
| novel trivalent vectored vaccine for control of myxomatosis and disease caused by classical and a new genotype of rabbit haemorrhagic disease virus. | myxoma virus (mv) and rabbit haemorrhagic disease virus (rhdv) are the major causes of lethal viral diseases in the european rabbit. in 2010, a new rhdv genotype (rhdv2) emerged in the field that had limited cross-protection with the classical rhdv (rhdv1). for optimal protection of rabbits and preventing spread of disease, a vaccine providing protection against all three key viruses would be ideal. therefore, a novel trivalent myxoma vectored rhdv vaccine (nobivac myxo-rhd plus) was developed s ... | 2020 | 32764375 |
| monitoring of emerging myxoma virus epidemics in iberian hares (lepus granatensis) in spain, 2018-2020. | myxomatosis is an infectious disease caused by the myxoma virus (myxv), which has very high mortality rates in european wild rabbits (oryctolagus cuniculus). while sporadic cases of myxomatosis have also been reported in some hare species, these lagomorphs are considered to have a low susceptibility to myxv infection. in the present study, we describe the spatiotemporal evolution and main epidemiological findings of novel hare myxv (ha-myxv or myxv-tol) epidemics in iberian hares (lepus granaten ... | 2020 | 32786107 |
| detection of recombinant hare myxoma virus in wild rabbits (oryctolagus cuniculus algirus). | in late 2018, an epidemic myxomatosis outbreak emerged on the iberian peninsula leading to high mortality in iberian hare populations. a recombinant myxoma virus (strains myxv-tol and ha-myxv) was rapidly identified, harbouring a 2.8 kbp insertion containing evolved duplicates of m060l, m061l, m064l, and m065l genes from myxoma virus (myxv) or other poxviruses. since 2017, 1616 rabbits and 125 hares were tested by a qpcr directed to m000.5l/r gene, conserved in myxv and myxv-tol/ha-myxv strains. ... | 2020 | 33028004 |
| recombinant myxoma virus infection associated with high mortality in rabbit farming (oryctolagus cuniculus). | myxomatosis is an emergent disease in the iberian hare, having been considered a rabbit disease for decades. genome sequencing of the strains obtained from iberian hares with myxomatosis showed these to be distinct from the classical ones that circulated in rabbits since the virus introduction in europe, in 1952. the main genomic difference in this natural recombinant hare myxoma virus (ha-myxv) is the presence of an additional 2.8 kb region disrupting the m009l gene and adding a set of genes ho ... | 2020 | 33119958 |
| [generation and evaluation of a recombinant myxomavirus expressing the vp60 protein of rabbit haemorrhagic disease virus]. | rabbit haemorrhagic disease virus (rhdv) and myxoma virus (myxv), are two pathogens that have harmful effect on rabbit breeding and population decline of european rabbits in their native range, causing rabbit haemorrhagic disease (rabbit fever) and myxomatosis, respectively. the capsid protein vp60 of the rhdv represents the major antigenic protein. to develop a recombinant bivalent vaccine candidate that can simultaneously prevent these two diseases, we used the nonessential gene tk (thymidine ... | 2020 | 33169573 |
| genetic characterization of a recombinant myxoma virus in the iberian hare (lepus granatensis). | myxomatosis is a lethal disease in wild european and domestic rabbits (oryctolagus cuniculus), which is caused by a myxoma virus (myxv) infection-a leporipoxvirus that is found naturally in some sylvilagus rabbit species in south america and california. the introduction of myxv into feral european rabbit populations of australia and europe, in the early 1950s, demonstrated the best-documented field example of host-virus coevolution, following a cross-species transmission. recently, a new cross-s ... | 2019 | 31181645 |
| first outbreak of myxomatosis in iberian hares (lepus granatensis). | myxomatosis is an infectious disease caused by myxoma virus (myxv; genus leporipoxvirus), which affects the european wild rabbit (oryctolagus cuniculus) and sporadically brown hares (lepus europaeus). here, we describe the first outbreak of myxomatosis in iberian hares (lepus granatensis). between mid-july and the end of september 2018, around 530 dead animals were detected in iberian hare populations in southern spain. the apparent mean mortality rate was 56.7%, and the estimated mean case fata ... | 2019 | 31293076 |
| ex vivo virotherapy with myxoma virus to treat cancer. | myxoma virus (myxv) is a member of the poxviridae family and the genus leporipoxvirus. in nature myxv tropism is restricted to lagomorphs, and is specifically pathogenic only for european rabbits (oryctolagus cuniculus), in which this virus causes the lethal systemic disease called myxomatosis. importantly, although myxv cannot cause any disease pathology in humans, mice, or any other domestic animals other than rabbit, this virus can productively infect and kill a variety of human and murine ca ... | 2020 | 31486033 |