| surgery for short esophagus with stricture: an experimental and clinical manometric study. | the surgical management of short esophagus with stricture has been simplified in recent years by the introduction of an esophageal lengthening procedure (collis gastroplasty) combined with antireflux maneuvers, such as the belsey and nissen operations. this report compares the experimental and clinical manometric findings after these procedures. after myectomy of the lower esophageal sphincter (les) in the cat, three experimental groups were developed including collis gastroplasty, collis-belsey ... | 1978 | 28698 |
| the effects of piperoxan on uptake of noradrenaline and overflow of transmitter in the isolated blood perfused spleen of the cat. | 1 the competitive alpha-adrenoceptor blocking agent, piperoxan, in concentrations up to 2 x 10(-4) m, produced large dose-dependent increases in transmitter overflow from the isolated blood perfused spleen of the cat following nerve stimulation at 10 hertz. 2 at concentrations greater than 2 x 10(-4) m, piperoxan produced a rise in perfusion pressure, a contraction of the splenic capsule, and a marked dose-dependent decrease in transmitter overflow. 3 phenoxybenzamine (10(-4) m) and desmethylimi ... | 1978 | 28808 |
| the distribution of calcium in hypoxic cat hearts: the effect of beta 1-blockade. | | 1978 | 28824 |
| central regulation of arterial blood pressure. | | 1975 | 28877 |
| the brain as a possible site for the cardiovascular effects of beta-adrenoceptor blocking agents in cats. | 1. dl-propranolol, l-propranolol, dl-alprenolol, pindolol (lb46), practolol, ici 66082, sotalol and oxprenolol all produced prolonged falls in blood pressure and heart rate after intracerebroventricular administration in conscious normotensive cats. 2. transient initial pressor responses and tachycardias were observed after intracerebroventricular infusions of all the beta-adrenoceptor antagonists used, except ici 66082. 3. d-propranolol, d-alphrenolol, procaine and lignocaine all produced initi ... | 1975 | 28878 |
| the fate of 7-3hisoproterenol in cats after intravenous administration. | the fate of intravenously administered 7-3hisoproterenol was investigated in cats. ten minutes after injection the concentration of 3h was highest in the heart, lungs, adrenals, and kidneys, but after 5 hr most of the radioactivity was found in the liver. the concentration of the unchanged drug in the serum declined in a biphasic manner with half-lives of 2.1--2.5 min for the first phase, and 58--77 min for the second phase. the drug was rapidly metabolized to 3-o-methylisoproterenol (misp) and ... | 1978 | 28929 |
| the hyperpnea of dynamic muscular exercise. | | 1977 | 28949 |
| micro-electrophoretic studies in the cat pulvinar region: effect of acetylcholine. | 1. in the posterior half of the pulvinar of cats anaesthetized with halothane and nitrous oxide, the majority of neurons were fired by ach released with small electrophoretic currents. in the anterior part of that nucleus, ach had more variable effects: excitation, depression or none. 2. in comparison with l-glutamate, dl-homocysteic acid and dl-aspartic acid, ach appeared to be the most potent excitant. 3. ach-induced discharges were easily and reversibly blocked by low doses of atropine. in mo ... | 1975 | 28959 |
| response characteristics of semicircular canal and otolith systems in cat. i. dynamic responses of primary vestibular fibers. | 1. the activity of cat semicircular canal and otolith afferents was studied during yaw and roll rotations, respectively, to examine their dynamic behavior. 2. a sinusoidal analysis of the canal afferent activities showed that their dynamic characteristics are similar to those of second order vestibular neurons, except for a two to three-fold lower absolute gain. this agrees with earlier studies using angular acceleration steps. 3. both divisions of the eighth nerve were sampled so as to examine ... | 1978 | 28960 |
| microiontophoretic study of the effect of gaba and taurine on the activity of cat motor cortex neurons. | | 1978 | 28963 |
| nonabdominal approach to castration of the cryptorchid cat. | | 1978 | 29025 |
| state and rhythmic processes. | | 1978 | 29061 |
| the antitussive actions of the drug ru 20201 given as an aerosol to cats. | the effect of the drug ru 20201 (1,2,3,4,4a,9b-hexahydro,-8,9b-dimethyl-4-3-(4-methylpiperazin-1-yl)propionamidodibenzofuran-3-one upon mechanically-evoked cough from the laryngopharyngeal and tracheobronchial areas in nine unanaesthetized cats has been examined. inhalation of 2 ml of an aerosol of a 10% solution in water suppressed coughing for 30 min. the effect was greatest on the number of cough efforts. the expiratory component of cough was suppressed more than was the inspiratory one. the ... | 1978 | 29095 |
| proceedings of the physiological society of japan. | | 1978 | 29121 |
| beta-adrenergic blocking agents. 18. 1-(aryloxy)-3-(arylthioalkylamino)propan-2-ols and 1-substituted alkylthioamino-3-(aryloxy)propan-2-ols. | the synthesis is described of a seris of derivaties of 1-(aryloxy)-3-(arylthioalkylamiho)propan-2-ols and 1-(alkylthioamino)- and 1-(aralkylamino)-3-(aryloxy)propan-2-ols. these compounds were investigated for their beta-adrenoreceptor blocking properties and their selectivity of action for the cardiac beta1 receptor. the structure-activity relationships are discussed with particular reference to the effects of the sulfur, sulfoxide, and sulfone groups on beta-adrenoreceptor blocking potency and ... | 1978 | 29123 |
| anaesthesia with fentanyl-metomidate in the cat and its effects on respiration and circulation. | | 1978 | 29167 |
| pharmacological demonstration of beta 1 selectivity of beta-receptor blockaders. | | 1978 | 29208 |
| is the hypotensive effect obtained by application of drugs to the ventral surface of the brain stem due to a membrane stabilizing mechanism? a study with beta-blockers. | | 1978 | 29255 |
| the effects of aceclidine, a muscarinic agonist, on neurons in the sensorimotor cortex of awake cats. | | 1978 | 29300 |
| the isolated nictitating membrane of the cat. a new model for the study of narcotic analgesics. | kinetic parameters of morphine and azidomorphine derivatives as well as methionine enkephalin methylester were determined on the electrically stimulated isolated medial smooth muscle of the cat nictitating membrane. the organ was found to be a promising in vitro model for testing the action of opiate agonists on opiate b receptors. | 1978 | 29316 |
| the effect of intravanginal electrical stimulation on the feline urethra and urinary bladder. neuronal mechanisms. | | 1977 | 29335 |
| the effects of catecholamines on the cardiovascular system. | | 1978 | 29344 |
| investigations into the free-living phase of the cat hookworm life cycle. | laboratory studies were undertaken to evaluate the role of environmental factors on the development of free-living stages of the cat hookworm ancylostoma tubaeforme. an index of development calculated from the proportion of eggs that developed to the infective stage and the reciprocal of the development period, has suggested that the absence of 'high' temperatures (26 degrees - 30 degrees c) would significantly affect the l3 population in contaminated soils. there were, however, no significant d ... | 1978 | 29389 |
| dynamics of the neurohumoral reactions of the resistive and capacitive vessels of a skin-muscle area in cats in the process of their adaptation to the high altitude of the tien shan. | | 1978 | 29402 |
| three compartments model for the bicarbonate exchange of the brain extracellular fluid with blood and cells. | | 1978 | 29459 |
| delayed ph equilibration in blood during carbonic anhydrase inhibition. | | 1978 | 29461 |
| aortic nerve chemoreceptors are sensitive to changes in paco2. | | 1978 | 29462 |
| colloid titration of heparin using cat-floc (polydiallyldimethyl ammonium chloride) as standard polycation. | | 1978 | 29516 |
| current data on pain pathways. | 1--the classical notion attributing the conduction of painful messages to only the a delta and c fibres will be discussed. 2--spinal cord cells of layers i, v and viii received painful messages and their physiological properties will be compared. 3--the origin within the cell layers of the spinal cord of the various ascending bundles will be examined. 4--the reticular an thalamic zones (posterior ventra nucleus, mid-line and intralaminar nuclei, gmme posterior group in particular) which receive ... | 1978 | 29525 |
| anatomy of the bulbospinal serotoninergic pathways in the cat. their role in morphine and electrically induced analgesia. | | 1978 | 29527 |
| morphine analgesia: neurobiologic data. | recent neurobiological (neurophysiological, histochemical, neurochemical and behavioural studies) data have indicated that the analgesic effects of morphine may, at least in part, be explained by two modes of action. a--morphine has a direct depressive action at a spinal level on the activity of neurones of the grey matter of the dorsal horn which run towards the higher centres of the encephalon. these effects are exerted preferentially on activities induced by the activity of fine non-myelinize ... | 1978 | 29530 |
| role of peptides in central neural transmission: substance p, bradykinin and beta-endorphine. | | 1978 | 29534 |
| electrophysiological effects of opiates and endogenous peptides on central neurons. | the influence of micro-iontophoretically administered opiates and opiate peptides on the activity of single neurones in the central nervous system will be discussed. it will be shown that in single neurone studies in several different supraspinal regions opiates and opiate peptides have similar actions on individual neurones and both may excite or depress neuronal activity. the excitatory and inhibitory effects of these substances can be reversed by a necrotic antagonist and therefore may be med ... | 1978 | 29535 |
| acupuncture: its neurophysiological basis: an anaesthetist's foreword. | | 1978 | 29773 |
| work in progress at the shanghai institute of physiology, division of acupuncture. | | 1978 | 29774 |
| effects of psychotropic drugs on the spinal ventral root reflexes in cats. a comparison of the depressant actions in intact and spinal preparations (author's transl). | effects of the typical psychotropic drugs such as neuroleptics, tricyclic antidepressants and benzodiazepines on the monosynaptic reflex (msr) and polysynaptic reflex (psr) were investigated using intact and spinal cats. drugs used were chlorpromazine, levomepromazine, perphenazine, prochlorperazine, droperidol, haloperidol, amitriptyline, imipramine, diazepam and flurazepam. neuroleptics depressed the ventral root reflexes markedly to slightly in both preparations. the inhibitory effects of the ... | 1978 | 29826 |
| an electrophysiological investigation of the sensitivity of intradental nerves in the cat to changes in the ionic composition of extracellular fluid. | | 1978 | 30435 |
| differences between presynaptic and postsynaptic alpha-adrenoceptors in the isolated nictitating membrane of the cat: effects of metanephrine and tolazoline. | the alpha-adrenoceptor blocking agent, tolazoline, and the o-methylated metabolite of adrenaline, metanephrine, produced a concentration-dependent increase of tension in the smooth muscle of the cat isolated nictitating membrane. these effects were considered to be due to the activation of postsynaptic alpha-adrenoceptors. 2 the responses to nerve stimulation of this muscle were neither potentiated nor blocked by tolazoline (0.1 to 10 micrometer) or metanephrine (1 to 10 micrometer). 3 3h-transm ... | 1978 | 30506 |
| the ganglionic blocking properties of the cholinesterase reactivator, hs-6. | following intravenous administration of the cholinesterase reactivator hs-6 (30 mg/kg), blood pressure fell (up to 50 mmhg) and maximal blood levels of hs-6 reached 242 microgram/ml. hs-6 attenuated the pressor response resulting from carotid occlusion and the depressor effect of vagal stimulation. doses of hs-6 below those used to protect against soman in different animal species (10--30 mumol/kg) progressively blocked the ganglion-stimulating effects of nicotine and dimethylphenylpiperazinium ... | 1978 | 30527 |
| a presynaptic component of the action of iontophoretically applied flurazepam on feline cortical neurones. | the effect of iontophoretically applied flurazepam on the spike activity of pericruciate cortical neurones of the cat was studied. flurazepam increased cortical inhibition produced either by local electrical stimulation (which is known to release gamma-aminobutyric acid (gaba) or by iontophoretically applied gaba. following intravenous treatment with thiosemicarbazide (a gaba-synthesis inhibitor), flurazepam still augmented the action of gaba but was much less effective on electrically evoked co ... | 1978 | 30528 |
| intracellular actions of monoamine transmitters. | intracellular injections of noradrenaline or dopamine in spinal motoneurones of cats have a clear depolarizing action associated with particularly marked depression of spike potentials and their after-hyperpolarization, but with little slowing-down of the falling phase of the action potential. these effects are associated with an increase in input resistance, and they are reversible and reproducible in the same neurone. intracellular injections of 5-hydroxytryptamine have some depolarizing actio ... | 1978 | 30529 |
| effects of orally ingested histamine and/or commercially canned spoiled skipjack tuna on pigs, cats, dogs and rabbits. | | 1978 | 30573 |
| effects of alpha-agonists on circulatory responses to somatic afferent nerve stimulation. | the effect of intracisternal (i.c.m.) injection of clonidine, noradrenaline, and piperoxane on the pressor response to electrical stimulation of a peripheral somatic afferent nerve was investigated using anaesthetized cats. it was found that noradrenaline caused a depression of the magnitude of the pressor response and this effect was antagonized by subsequent injection of piperoxane i.c.m. in contrast, clonidine had no significant effect on the magnitude of the somatic pressor reflex but caused ... | 1978 | 30638 |
| dynamics of respiratory vt response to isocapnic pha forcing in chemodenervated cats. | arterial blood ph (pha) was continuously monitored in decerebrate or pentobarbital-anesthetized cats with a rapidly responding hydrogen ion sensor inserted into the aorta. alveolar carbon dioxide partial pressure and pha were controlled independently during infusions of 1 n nahco3 or 0.5 n hcl into the inferior vena cava. shifts in pha up to 0.3 unit were effected isocapnically within 2.5-20 s over a working pha range of 6.9-7.7. before carotid sinus neurotomy, average onset latency of the tidal ... | 1978 | 30740 |
| slow postcapillary changes in blood ph in vivo: titration with acetazolamide. | a stopped-flow ph electrode apparatus was used to investigate the mechanisms underlying slow changes in plasma ph (pho) after blood leaves the pulmonary capillaries in carbonic anhydrase-inhibited animals. after acetazolamide was administered to an anesthetized dog or cat, arterial blood was withdrawn through the electrode apparatus into a syringe. syringe movement was then suddenly stopped. temperature and pho of the blood in the electrode chamber were monitored both before and after blood with ... | 1978 | 30741 |
| comparative metabolism of lorazepam in man and four animal species. | the metabolic disposition of lorazepam (wy-4036) in man, dog, cat, rat and miniature swine is compared. except in the cat, absorption of lorazepam is rapid in these species. absorption in humans is nearly complete. lorazepam glucuronide is the major metabolite in all species except the rat in which a dihydrodiol derivative is the main product of lorazepam biotransformation. lorazepam glucuronide, which has no demonstrable cns activity, is also present in the plasma of all species investigated. t ... | 1978 | 30761 |
| pharmacology of lorazepam. | lorazepam reduced conflict behavior in rats and monkeys, inhibited pentylenetetrazol- and electroshock-induced convulsions, suppressed footshock-induced fighting behavior, and prevented morphine-induced stimulation in mice at lower doses than other benzodiazepines tested. this behavioral profile suggests that lorazepam will be an active anti-anxiety agent in man at low doses. | 1978 | 30764 |
| the pathogenesis of hypertensive encephalopathy. experimental data and their clinical relevance with special reference to neurosurgical patients. | | 1978 | 31065 |
| otolith responses of extraocular muscles during sinusoidal roll rotations. | | 1979 | 31231 |
| effect of arrhythmogenic doses of deslanoside on the uptake of monoamines in brain tissue and in cardiac tissue. | the purpose of our study was to determine whether a toxic arrhythmogenic dose of digitalis administered to an in vivo preparation would affect the neuronal uptake of norepinephrine, serotonin and dopamine in brain tissue and norepinephrine in cardiac tissue. this was investigated by intoxicating anesthetized cats with deslanoside, removing cardiac and brain tissue at the onset of ventricular fibrillation, and examining the ability of brain tissue to accumulate [3h]-ne, [3h]-t-ht and [3h]-da and ... | 1978 | 31290 |
| steroidogenic cellular sites in the cat ovary: a histochemical study. | | 1978 | 31316 |
| [report of the conference for inner ear biology, bordeaux 1977 (author's transl)]. | | 1978 | 31340 |
| studies with brugia pahangi. 18. anthelmintic effects of stibocaptate. | stibocaptate (asiban, hoffman--la roche) killed third stage larvae of brugia pahangi in vitro at 50 p.p.m. but had no effect on microfilariae at 1 x 10(4) p.p.m no larvae developed in infected mosquitoes fed 1% stibocaptate in 10% sucrose. it was neither micro-nor macrofilaricidal in either jirds or cats but did affect embryogenesis. | 1978 | 31379 |
| nondepressant beta-adrenergic blocking agents. 1. substituted 3-amino-1-(5,6,7,8-tetrahydro-1-naphthoxy)-2-propanols. | a series of 3-amino-1-(5,6,7,8-tetrahydronaphthoxy)-2-propanols was synthesized and investigated for beta-adrenergic blocking activity and direct myocardial depressant action. the cis- and trans-diols 12--15 were found to retain the beta-blocking potency of propranolol but to lack its myocardial depressant action. compound 15 (nadolol) is currently undergoing extensive clinical evaluation as a potential antianginal, antiarrhythmic, and antihypertensive agent. | 1978 | 31485 |
| cardioselectivity as a function of molecular structure in beta-adrenoceptor blocking agents of the 1-(para-substituted aryloxy)-3-(isopropylamino)propan-2-ol type. | the relationship between molecular structure and cardioselectivity is described in the 1-(para-substituted aryl-oxy)-3-(isoprophylamino)propan-2-ol type of beta-adrenoceptor blocking agents. cardioselectivity in the aforementioned series requires that the aromatic substitution in the position para to the amino alcohol side chain will have a minimal linear length of 5.0 a. highest cardioselectivity is obtained when this para substituent is a rigid group coplanar with the aromatic ring. this may r ... | 1978 | 31488 |
| effects of dopamine agonists on neurones in the caudate nucleus and cerebral cortex of cats chronically treated with neuroleptics. | | 1978 | 31577 |
| [relationship of seizure susceptibility and generalized convulsion to brain monoamine concentration in the kindled cat brain (author's transl)]. | | 1978 | 31638 |
| [effect of papaverine on h+ transport in suspension of cat brain mitochondria]. | the intravenous administration of papaverin (3 mg/kg) under conditions of acute experiments showed that it is able to induce a considerable increase in intensity of h+ release from mitochondria of the cat brain tissue cells. taking into consideration the data of previous researches testifying to the fact taht under the papaverine influence there occurs h+ accumulation in cells due to metabolism intensification, it may be suppose that an intensified release of h+ from the mitochondria plays a def ... | 1978 | 31719 |
| effect of intraantral ph on basal gastrin release into the circulation and antral lumen in anesthetized cats. | in acute experiments on cats antral pouches were perfused with solutions of different ph (1-13). after antrum passage the gastrin levels in the perfusates were measured with radioimmunoassay and the amounts of gastrin released into the antral lumen per minute calculated. the venous gastrin levels were determined concomitantly. small amounts of gastrin (1,000--1,500 pg/min) were released into the antrum during perfusion with 0.1 m hcl. subsequent perfusion with 0.15 m nacl (ph 6.8) did not signif ... | 1978 | 31763 |
| the pancreatic duct mucosal barrier. | the main pancreatic duct in cats possesses a relatively strong barrier to the diffusion of bicarbonate ions (hco3-). we studied some of the characteristics of this barrier by perfusing the duct with a solution similar in composition to pancreatic juice before and after exposing the duct mucosa to various test agents. the difference in net flux of hco3- across the duct before and after exposure to the test agent reflected damage to the barrier. the barrier was damaged by infected bile, aspirin (p ... | 1979 | 31807 |
| [hyperglycemic effect and glycogenolytic action of catecholamines]. | | 1978 | 31843 |
| [local measurements of po2 and ph2 in the basal winding of the cat's cochlea after acute upper cervical sympathectomy using micro coaxial needle electrodes]. | | 1978 | 31855 |
| the effects of intracisternal administration of alpha-adrenoreceptor agonists on the systemic blood pressure and its response to head-up tilting in anaesthetized cats. | | 1978 | 31996 |
| the interaction between prazosin and clonidine. | 1. the interaction between prazosin and clonidine was studied in anaesthetized rats, pithed rats and in anaesthetized cats. 2. prazosin diminished the clonidine-induced hypotensive effect in anaesthetized rats, probably via an antagonism at the level of central alpha-adrenoreceptors. 3. in pithed rats, stimulation of the nervi accelerantes caused tachycardia, which was diminished considerably by clonidine. the antagonism by clonidine was partly reversed by prazosin, suggesting that prazosin poss ... | 1978 | 32005 |
| [chemically modified hemoglobin--artificial oxygen carrier]. | | 1978 | 32022 |
| effects of the unilateral nigral application of dopaminergic drugs on the in vivo release of dopamine in the two caudate nuclei of the cat. | the effects of the unilateral application of d-amphetamine, benztropine, haloperidol and thioproperazine to one substantia nigra on the release of 3h-dopamine (3h-da) in the two caudate nuclei were examined in halothane-anesthetized cats. for this purpose animals were implanted with push-pull cannulae and 3h-da was estimated in superfusates during the continuous delivery of l-3,5-3h-tyrosine. the nigral application of d-amphetamine (10-6 m) or benztropine (10-6 m) reduced the release of 3-h-da i ... | 1979 | 32060 |
| histamine receptors in the gastric microcirculation. | the types and functions of histamine receptors in the submucosal arterioles of the corpus and antrum of the cat and rat stomach were studied using an in vivo microscopy technique. change in arteriolar diameter in response to superfusion of histamine with and without antagonists was measured by an image-splitting technique. h1 and h2 histamine receptors subserving vasodilatation were demonstrated in both the antral and corpus submucosal arterioles of the cat and rat. however, the h1 effect was pr ... | 1978 | 32123 |
| slow postcapillary ph changes in blood in anesthetized animals. | to investigate the hypothesis that blood ph and pco2 continue to change after the blood leaves an exchange capillary, we used a rapidly responding, pressure-insensitive, stopped-flow ph electrode apparatus. arterial blood from an anesthetized dog or cat is drawn through the apparatus into a syringe. syringe movement is then suddenly stopped. temperature and ph of the blood in the electrode assembly are continuously monitored, both before and after blood withdrawal ceases. hemolysis was reduced b ... | 1978 | 32160 |
| sensitivity of the carotid body to within-breath changes in arterial pco2. | respiration, sinus nerve chemoreceptor discharge, and carotid arterial ph were monitored in cats. chemoreceptor discharge frequency showed oscillations that had a respiratory period when averaged over many respiratory cycles. these oscillations disappeared when ph oscillations of respiratory period were eliminated from the carotid arterial blood. the maximum sinus nerve discharge was associated with the most acid point of the recorded ph oscillation. briefly increasing pco2 by giving co2-rich sa ... | 1978 | 32161 |
| monensin potentiation of potassium contracture in cat myocardium. | | 1978 | 32383 |
| time course of changes of extracellular h+ and k+ activities during and after direct electrical stimulation of the brain cortex. | the kinetics of h+ and k+ activities were recorded during and after direct electrical activation of the brain cortex (cat). h+ activity was measured with h+-sensitive glass microelectrodes (tip diameters of 1--4 micron) and k+ activity was registered with double-barrelled ion-sensitive microelectrodes (tip diameters of 1--3 micron). it could be shown that extracellular h+ activity initially decreased for a few seconds and increased only after the 7.s. maximum acidosis was always noticed after st ... | 1978 | 32522 |
| [histamine and its role in peptic gastric diseases: the discovery of histamine-h2-receptor antagonists]. | for the definition of histamine receptors the following prerequisites must be fulfilled: (1) course of dose-response curves according to the mass-action law; (2) parallel displacement of these curves to the right in the presence of antagonists; (3) inhibition only by specific histamine antagonists; (4) slope of a schild-plot not significantly different from unity. for h2-receptors these prerequisites could ideally be fulfilled, especially by the development of highly specific h2-receptor antagon ... | 1978 | 32719 |
| effect of physostigmine-eunalgit interaction upon alimentary motor reflexes in cats. | | 1978 | 32727 |
| haemodynamic effects of the quaternary ammonium compound qx 572 in anaesthetized cats. iii. interactions with adrenergic beta-adrenoceptor blockade. | the positive cardiac chronotropic effects of the antiarrhythmic compound, qx 572, in anaesthetized cats has been shown mainly to be due to a release of catecholamines from sympathetic nerve-endings. furthermore, these undesired effects of qx 572 on heart rate were decreased by adrenergic beta blockade in the animals. in the present study it was found that an adrenergic beta-blockade did not reveal any cardiodepressive effects of qx 572, that in the normal animals might have been masked by the ef ... | 1979 | 32739 |
| lack of release of prostaglandins from isolated perfused lungs during pulmonary hypertension and oedema. | 1 the effects on pulmonary prostaglandin synthesis of pulmonary hypertension and oedema have been studied. 2 seventeen isolated lungs of rabbit, cat and guinea-pig were perfused with plasma, whole blood or krebs ringer solution in a recirculating system. 3 the venous effluent from the lungs superfused (10 ml/min) a series of smooth muscle tissues sensitive to prostaglandins and thromboxane a2; these were: rat stomach strip, rat colon, chick rectum and rabbit aorta. 4 left atrial pressure was inc ... | 1979 | 32945 |
| the dilating effect of histamine on pial arteries of cats and its mediation by h2 receptors. | we studied the effect of histamine and h1 or h2 blockers on the diameter of pial arteries (39-227 micron) using microapplication into the perivascular space. concentration-response curves for histamine showed dilations which started at 10(-7) m and were maximal at 10(-5) and 10(-4) m. the h2 blocker, cimetidine, induced no vascular reaction over the whole concentration range tested (10(-7) to 10(-3) m). the h1 blocker, mepyramine, was not vasoactive in the concentration range from 10(-7) to 5 x ... | 1979 | 32970 |
| phospholipid analysis of the chick ventricles in the early stages of development when their excitability changes in tetrodotoxin or in sodium substitute media. | | 1978 | 32996 |
| comparison of the effects of diflunisal and other salicylates on the intragastric electropotential. | | 1979 | 33243 |
| [mechanisms of local anesthetic seizures (author's transl)]. | | 1979 | 33280 |
| cns site of beta-adrenergic blocker-induced hypotension in the cat: a microiontophoretic study of bulbar cardiovascular neurones. | | 1979 | 33346 |
| role of carotid body catecholamines in chemoreceptor function. | | 1978 | 33349 |
| [effect of action potentials and synaptic excitation on rna and protein metabolism in nerve tissue]. | | 1978 | 33501 |
| a study of the ph monitor in cats. | a study of the accuracy of the tph electrode was performed in 10 cats. hypoxia and acidosis were produced by ventilatory means and bicarbonate infusions were used to elevate the ph . tissue ph correlated well with arterial (r = 0.9) within the physiological rates of change of ph. prolonged tissue acidosis lead to eventual death. the correct and stable mechanical fixation of the ph electrode is a critical factor in assuring accurate results. the roche tph electrode accurately reflects arterial ph ... | 1978 | 33620 |
| unit activity of limbic system neurons: effects of morphine, diazepam and neuroleptic agents. | the effects of morphine, diazepam and three neuroleptic agents (chloropromazine, perphenazine and haloperiodol) on neuronal firing rats were studied in the limbic system of immobilized cats. parietal craniotomy was carried out under 1.5--4.0% halothane. extracellular potentials from single cells in the cingulate gyrus, septum and lateral hypothalamic areas were recorded using glass-coated, platinum-iridium microelectrodes. in general, intravenous adminstration of morphine sulfate augmented the s ... | 1979 | 33749 |
| pial arterial reactions to hyper- and hypocapnia: a dynamic experimental study in cats. | in 29 cats, the extent and time-course of the pial arterial reactions to hypo- and hypercapnia were studied by means of the skull-window technique. the typical, well-known dilatations and constrictions during hyper- and hypocapnia were seen. the latent period for dilatation after the beginning of co2-inhalation was ca. 20 sec. there was no stable relation observable between vessel diameter and arterial carbon dioxide tension (paco2). diameter changes lagged behind co2-changes, indicating that co ... | 1978 | 33809 |
| proceedings of the international embryo transfer society. fifth annual conference - 14-16 january, 1979. | | 1979 | 33864 |
| some factors influencing the neurotoxicity of intrastriatal injections of kainic acid. | intrastriatal injections of kainic acid are known to destroy striatal neurons including many containing choline acetyltransferase (cat) and glutamic acid decarboxylase (gad). using these enzymes as indices of neuronal loss, the neurotoxicity of small doses of kainic acid was found to be influenced by injection time and volume. it was partly blocked by coinjection of some but not all glutamate antagonists or by prior lesioning of the corticostriatal tract. other adjuvants, drugs, or lesions teste ... | 1978 | 34114 |
| the correlation between discharge times of neighbouring neurons in isolated cerebral cortex. | the purpose of the experiments was to find out whether neighbouring neurons in chronic preparations of neurally isolated cerebral cortex are more likely to fire synchronously than are similar neurons in the intact brain. chronically implanted extracellular microelectrodes were used to obtain simultaneous records of the spontaneous discharges of neighbouring neurons in the suprasylvian gyrus of the unanesthetized, unrestrained cat. we have examined multi-unit records obtained from neurons in isla ... | 1979 | 34158 |
| the pharmacology of aggressive behavioural phenomena elicited by muscarine injected into the cerebral ventricles of conscious cats. | | 1979 | 34184 |
| ontogenesis of some sleep regulations: early postnatal impairment of the monoaminergic systems. | | 1978 | 34197 |
| effects of l-nuciferine on kainate, n-methyl-d-aspartate and acetylcholine excitation of cat spinal neurons. | | 1979 | 34695 |
| picrotoxin- and bicuculline-sensitive inhibition of cardiac vagal reflexes. | transmission in the cardiac vagal reflex pathway can be inhibited by stimulation of the hypothalamic defense region or somatic afferent nerves. a pharmacological analysis of inhibitory modulation of reflex vagal bradycardia was undertaken in the present study. picrotoxin (0.5--1.5 mg/kg i.v.) or bicuculline (0.5--1.5 mg/kg i.v.) produced a dose-related blockade of inhibition of reflex vagal bradycardia elicited by stimulation of the lateral hypothalamus or branches of the brachial plexus in spin ... | 1979 | 34717 |
| comparison of the open skull and cranial window preparations in the study of the cerebral microcirculation. | | 1978 | 34775 |
| serum potassium in lactic acidosis and ketoacidosis. | | 1979 | 34793 |
| vasomotor rhinitis--pathophysiological aspects. | vasomotor rhinitis is commonly defined as an unspecific hyperractivity of the nasal mucosa. the symptoms might be due to increased parasympathetic activity to the nose with the release of vaso-secretory active substances. experimental data from the cat suggest that the postganglionic parasympathetic mediator of nasal secretion is cholinergic, whereas the vascular responses appears to be due to a different mechanism. apart from a rich sympathetic and parasympathetic innervation of the nasal mucos ... | 1979 | 34866 |
| effects of beta-adrenoceptor agonists on airway smooth muscle and on slow-contracting skeletal muscle: in vitro and in vivo results compared. | ten beta-adrenoceptor agonists were examined with respect to a) relaxation of pilocarpine-contracted trachea and depression of contractions of the soleus muscle of the guinea-pig in vitro and b) counteraction of histamine-induced bronchospasm and depression of contractions of the soleus muscle of the cat in vivo. there was a close correlation between the results obtained in vitro and results obtained on the corresponding tissues in vivo in spite of the different species used. a close correlation ... | 1979 | 34976 |
| acid-base equilibrium during acute long-lasting experiments in artificially ventilated cats. | experiments were carried out to study blood acid-base equilibrium in the cat during experiments with artificial ventilation. blood acid-base equilibrium was examined in the arterial and venous blood by analyzing ph, carbon dioxide and oxygen partial pressure, and plasma bicarbonates. artificial ventilation was regulated on the basis of this analysis; co2 concentration in expired air was monitored throughout the experiment. an attempt was made to verify if artificial ventilation could be regulate ... | 1979 | 35011 |
| [general pharmacology of dobutamine]. | | 1978 | 35056 |
| [morphohistochemical characteristics of structures of the esophageal cross-striated muscle tissue]. | on the bases of histochemical enzymatic studies and morphometric investigations, some differences were revealed between cross-striated esophageal muscular tissue and other skeletal muscles of mammals. a peculiar feature of the esophageal musculature is prevalence of unitypical fibres with small diameter and possessing high activity of oxidating enzymes. according to these signs, esophageal myons can be ascribed to the first type of muscular fibres. simultaneously, a high activity of myofibrillar ... | 1979 | 35136 |
| [the influence of 2-ethyl-3-(4-hydroxy-benzoyl)- benzofuran on the contraction of pial arterial muscles (author's transl)]. | by means of perivascular perfusion of thin sections of pial arteries with differently composed cerebrospinal fluid (csf) the vessel diameters can be influenced. in cats, anesthetized with pentobarbital, addition of serotonin, norepinephrine or calcium to an artificial csf which was infused through micropipettes into the perivascular space of the pial arteries, caused constrictions of the arteries contacting the modified csf. hyperventilation or perivascular perfusion of alkaline csf also caused ... | 1978 | 35167 |