| bone alp and oc reference standards in adult baboons (papio hamadryas) by sex and age. | serum bone-specific alkaline phosphatase (bone alp) and intact osteocalcin (oc) are markers of bone formation of interest because of easy measurability and potential utility as identifiers of those at risk for fractures associated with bone metabolism disorders. the baboon (papio hamadryas) exhibits extensive biological similarities to humans making it particularly well suited to studies of bone maintenance and turnover. | 2006 | 16556296 |
| one-male units and clans in a colony of hamadryas baboons (papio hamadryas hamadryas): effect of male number and clan cohesion on feeding success. | in the multilevel societies of hamadryas baboons, adult males can be attached to single one-male units (omus) or to clans containing several such omus. this paper examines the effect of male number and rivalry between males within a clan on their ability to compete for access to a clumped food resource. the data come from a study of a multilevel colony of hamadryas baboons (papio hamadryas hamadryas) housed at the madrid zoo. the colony consisted of 12 harem-holding males and 40 sexually mature ... | 2006 | 16419105 |
| cranial ontogeny of papio baboons (papio hamadryas). | cranial form in subspecies of papio baboons (papio hamadryas) varies in relation to size, geography, and sex. however, knowledge about this variation is based mainly on adults, precluding direct assessments of the evolutionary factors that are ultimately responsible for adult shape variation. consequently, this study tests hypotheses about the development of size and shape differences among subspecies of papio baboons, anticipating limited evolutionary divergences in the ontogenetic pathways lea ... | 2006 | 16345071 |
| early sexual maturity in male hamadryas baboons (papio hamadryas hamadryas) and its reproductive implications. | we present data on sexual maturity in young hamadryas baboon males (papio hamadryas hamadryas) and its reproductive consequences in a large captive baboon colony. hamadryas baboons live in a multilevel social system, with one-male units (omus) as the smallest social entity. male leaders of omus are believed to monopolize matings within their omus; hence mating is believed to be polygynous and monandrous. in a captive colony of hamadryas baboons, we found evidence that young males less than 4 yea ... | 2006 | 16331661 |
| a male baboon (papio hamadryas) with a mosaic 43,xxy/42,xy karyotype. | | 2006 | 16315270 |
| regularities and diversity in developmental pathways: mother-infant relationships in hamadryas baboons. | change, stasis, stability, discontinuity, orderliness, and diversity are all potential characteristics of developmental systems. this study uses multilevel modeling to characterize the normative developmental pathways of the early social relationships of 23 mother-infant pairs embedded in a multilayered colony of hamadryas baboons (papio hamadryas hamadryas). the relationships were assessed by means of 27 behavioral measures that were collected during 100-220 focal sampling sessions per infant, ... | 2005 | 16284971 |
| experimental heatstroke in baboon: analysis of the systemic inflammatory response. | the objective of this study was to analyze the pattern of the inflammatory response to heatstroke in an experimental baboon model with a view to identifying potential target for therapeutic interventions. blinded analysis of plasma collected from 12 juvenile baboons (papio hamadryas) in heatstroke was used. eight anesthetized animals were heat-stressed in an incubator at 44 degrees c to 47 degrees c until rectal temperature was 42.5 degrees c (moderate heatstroke; n = 4) or systolic arterial pre ... | 2005 | 16205317 |
| mother-infant relationships in baboons (papio hamadryas): predictors of differences and discontinuities in developmental pathways. | this study uses hierarchical linear regression modeling to analyze sources of variation in the developmental pathways of mother-infant relationships and to search for behavioral discontinuities. the data come from 23 mother-infant dyads of baboons (papio hamadryas), whose interactions were recorded longitudinally during the infants' 1st year of life. the infant's sex and the mother's age and reproductive experience accounted for part of the variation observed in the developmental pathways of 11 ... | 2005 | 16131260 |
| synthesis and in vivo evaluation of a novel peripheral benzodiazepine receptor pet radioligand. | the novel pyrazolopyrimidine ligand, n,n-diethyl-2-[2-(4-methoxyphenyl)-5,7-dimethyl-pyrazolo[1,5-a]pyrimidin-3-yl]-acetamide 1 (dpa-713), has been reported as a potent ligand for the peripheral benzodiazepine receptor (pbr) displaying an affinity of k(i)=4.7 nm. in this study, 1 was successfully synthesised and demethylated to form the phenolic derivative 6 as precursor for labelling with carbon-11 (t(1/2) = 20.4 min). [11c]1 was prepared by o-alkylation of 6 with [11c]methyl iodide. the radioc ... | 2005 | 16039131 |
| pleiotropic effects of genes for insulin resistance on adiposity in baboons. | previous research has suggested a genetic contribution to the development of insulin resistance and obesity. we hypothesized that the same genes influencing insulin resistance might also contribute to the variation in adiposity. | 2004 | 15601971 |
| application of piecewise hierarchical linear growth modeling to the study of continuity in behavioral development of baboons (papio hamadryas). | in behavioral science, developmental discontinuities are thought to arise when the association between an outcome measure and the underlying process changes over time. sudden changes in behavior across time are often taken to indicate that a reorganization in the outcome-process relationship may have occurred. the authors proposed in this article the use of piecewise hierarchical linear growth modeling as a statistical methodology to search for discontinuities in behavioral development and illus ... | 2004 | 15482059 |
| genotype-by-sex and environment-by-sex interactions influence variation in serum levels of bone-specific alkaline phosphatase in adult baboons (papio hamadryas). | while more than 77% of the people in the us with osteoporosis are women, the contributions of genotype-by-sex (g x s) and environment-by-sex interactions to sex differences in osteoporosis risk factors have not been studied. to address this issue, we conducted a statistical genetic analysis of serum concentrations of bone-specific alkaline phosphatase (bone alp), a highly specific marker of osteoblast function that is elevated in persons with conditions like osteoporosis characterized by excessi ... | 2004 | 15207757 |
| male chacma baboons (papio hamadryas ursinus) discriminate loud call contests between rivals of different relative ranks. | males in multi-male groups of chacma baboons (papio hamadryas ursinus) in botswana compete for positions in a linear dominance hierarchy. previous research suggests that males treat different categories of rivals differently; competitive displays between males of similar rank are more frequent and intense than those between disparately ranked males. here we test whether males also respond differently to male-male interactions in which they are not directly involved, using playbacks of the loud ' ... | 2005 | 15164259 |
| intraperitoneal foreign body disease in a baboon (papio hamadryas). | in a baboon group housed at the german primate center one animal became conspicuous with signs of massive abdominal pain in the upper gastric region. after clinical investigation an acute bloat-syndrome was suspected as cause of the animals' sickness. symptomatic therapy was started but the animal died within a few hours. at necropsy a large piece of wood was found within the right kidney and liver. prior to this, the foreign body passed the gastrointestinal tract and perforated the proximal col ... | 2004 | 15061725 |
| fecal cortisol levels in free-ranging female chacma baboons: relationship to dominance, reproductive state and environmental factors. | savannah baboons are one of the few mammalian species that do not exhibit seasonal reproduction patterns and are therefore ideally suited to study the effect of female reproductive states (cycling, pregnant, lactating) on cortisol levels independent of seasonal factors. fecal samples from 10 free-ranging female chacma baboons (papio hamadryas ursinus), collected during a period of 17 months, were analyzed using a steroid-extraction method. reproductive state had a significant effect on fecal cor ... | 2004 | 15053942 |
| genetics of monoamine metabolites in baboons: overlapping sets of genes influence levels of 5-hydroxyindolacetic acid, 3-hydroxy-4-methoxyphenylglycol, and homovanillic acid. | monoamine neurotransmitters (serotonin, dopamine, and norepinephrine) are associated with several psychiatric disorders. limited evidence suggests that monoamine levels are heritable, but no information concerning genetic relationships among monoamines is available. further genetic analysis can help explain phenotypic correlations among monoamine levels and might eventually help identify genes involved in response to therapy or risk of psychopathology. | 2004 | 15039003 |
| trade-offs in skillacquisition and time allocation among juvenile chacma baboons. | we hypothesize that juvenile baboons are less efficient foragers than adult baboons owing to their small size, lower level of knowledge and skill, and/or lesser ability to maintain access to resources. we predict that as resources are more difficult to extract, juvenile baboons will demonstrate lower efficiency than adults will because of their lower levels of experience. in addition, we hypothesize that juvenile baboons will be more likely to allocate foraging time to easier-to-extract resource ... | 2004 | 26190293 |
| infant mortality after takeovers in wild ethiopian hamadryas baboons. | in this work we report the first observational evidence of infanticide in wild hamadryas baboons. the study group inhabits the lowlands of the northern rift valley in ethiopia and has been under observation for over 1,200 hr, on and off, since october 1996. here we report observations from august and september 2002 of the consequences of two takeovers of known females with black infants. after the first takeover, the respective infant disappeared and was presumed dead within 11 days of the takeo ... | 2003 | 12874842 |
| genetics of leptin expression in baboons. | leptin gene expression is higher in females than in males, and is regulated by many factors including energy intake and insulin, but little is known about the inheritance of leptin gene expression. we have investigated leptin (lep) gene express-ion, to determine whether it is heritable, and whether the difference in lep expression between males and females has a genetic component. | 2003 | 12821961 |
| discordance of endothelial nitric oxide synthase in the arterial wall and its circulating products in baboons: interactions with redox metabolism. | although peripheral arteries and circulating factors have been frequently used to assess systemic or central arterial, such as coronary artery, endothelial nitric oxide synthase (enos) functions, there is no direct evidence to support that they are related. | 2003 | 12662158 |
| life history and the competitive environment: trajectories of growth, maturation, and reproductive output among chacma baboons. | the social environment is a key feature influencing primate life histories. chacma baboons (papio hamadryas ursinus) are a female-bonded species with a strict linear dominance hierarchy. in this species, the allocation of energy to competing demands of growth and reproduction is hypothesized to vary as a function of competitive ability, which in turn increases with social rank. since growth rate is a major component of life history models, measures of age-specific growth were used to analyze var ... | 2003 | 12489139 |
| trace elements concentrations from papio hamadryas teeth sequences. | | 2001 | 11603830 |
| rank and grooming reciprocity among females in a mixed-sex group of captive hamadryas baboons. | in a mixed-sex, captive group of hamadryas baboons (papio hamadryas hamadryas) we investigated whether female grooming relationships are affected by their dominance ranks. seyfarth's [1977] grooming for support model and barrett et al.'s [1999] biological market model both predict that in primate groups where competition for monopolizable resources is high, grooming among females is based, at least partly, on the interchange of grooming for rank-related benefits, and that rank thus influences th ... | 2001 | 11536314 |
| cardiovascular structure and function in baboons with type 1 diabetes -- a transvenous ultrasound study. | diabetes mellitus is an important risk factor for both macrovascular and cardiac disease in humans. the availability of a novel intravenous ultrasound probe allows detailed interrogation of a large proportion of the vasculature, as well as the heart, during the same examination. six male baboons (papio hamadryas) with type 1 diabetes and known microangiopathy, and six control animals were studied. vascular structure in the major large arteries and cardiac function were studied using transvenous ... | 2016 | 11457668 |
| the effects of the menstrual cycle, pregnancy and early lactation on haematology and plasma biochemistry in the baboon (papio hamadryas). | the changes in the haematology and clinical biochemistry associated with the different stages of the menstrual cycle, gestation and lactation in the baboon (papio hamadryas) were evaluated in a prospective longitudinal study. serial edta and heparin blood samples were collected from 12 baboons. haemoglobin concentration, haematorcrit, red blood cell and white blood cell counts were decreased in the luteal compared to the follicular phase (p<0.001); the reverse effect was observed for platelet co ... | 2000 | 11168833 |
| changes of hormonal function of the adrenal and gonadal glands in baboons of different age groups. | the purpose of this study was to characterize the changes of hormonal function of the adrenals and gonads during aging in male baboons (papio hamadryas). basal levels of plasma dehydroepiandrosterone, dehydroepiandrosterone sulfate, pregnenolone, and 17-hydroxypregnenolone progressively decrease with age from 10-15 years when analyzed by specific radioimmunoassay. however, no significant changes were found in cortisol and 11-desoxycortisol concentrations. the levels of sexual hormones did not di ... | 2000 | 10870672 |
| two takeovers in wild hamadryas baboons. | | 2006 | 10828697 |
| sexual swellings in female hamadryas baboons after male take-overs: "deceptive" swellings as a possible female counter-strategy against infanticide. | in many primate species, male intanticide is assumed to pose a serious risk for infants, and therefore female counter-strategies are expected. these counter-strategies may include changes in the females' reproductive behavior and physiology, e.g., mating with multiple males and prolonged receptivity. since the risk of infanticide is particularly high when a new male enters the group or when a male rises in rank, we studied the changes in female reproductive conditions, e.g., post-partum amenorrh ... | 2000 | 11132110 |
| long-term survival and function of intrahepatic islet allografts in baboons treated with humanized anti-cd154. | clinical islet cell transplantation has resulted in insulin independence in a limited number of cases. rejection, recurrence of autoimmunity, and impairment of normal islet function by conventional immunosuppressive drugs, e.g., steroids, tacrolimus, and cyclosporin a, may all contribute to islet allograft loss. furthermore, intraportal infusion of allogeneic islets results in the activation of intrahepatic macrophages and endothelial cells, followed by production of proinflammatory mediators th ... | 1999 | 10389857 |
| biochemistry and haematology values for the baboon (papio hamadryas): the effects of sex, growth, development and age. | a retrospective study evaluated the influence of sex and age on plasma biochemistry and haematology parameters in a captive-bred colony of baboons. over 1,140 etda and heparin blood samples were obtained from 160 clinically normal baboons between the ages of 11 months and 11 years. data for these blood tests were analysed for the effects of sex, age and sex age interactions. sex, age and sex age interactions were detected for many plasma biochemistry and haematological parameters. the reference ... | 1999 | 10372537 |
| [evoked potentials in the sacred baboon: long-term follow-up of intracerebroventricular infusion of nerve growth factor]. | it is well known that in aged animals cognitive deficit occurs, homologous with that occurring in alzheimer's disease in humans, and as has been shown in others species, this may be attenuated by administration of nerve growth factor (ngf). therefore the basic aim of this study was to make an electrophysiological evaluation of the repercussion that there might be after long-term administration of this neurotropin in the sacred baboon (papio hamadryas) comparing aged with young animals. | 2009 | 10363290 |
| cerebrospinal fluid monoaminergic metabolites differ in wild anubis and hybrid (anubis hamadryas) baboons: possible relationships to life history and behavior. | the article reports monoaminergic metabolite [homovanillic acid (hva), 5-hydroxyindoleacetic acid (5-hiaa), and 3-methoxy-4-hydroxyphenylglycol (mhpg)], values from the cerebrospinal fluid (csf) of 27 wild baboons (papio hamadryas) aged 40 to 140 months. animals were either anubis, or anubis with hamadryas admixture; males of the latter subspecies generally have a reduced tendency to disperse from their natal groups. overall, the values and interrelationships among the csf monoamine metabolites ... | 1999 | 10327421 |
| pleiotropy and genotype by diet interaction in a baboon model for atherosclerosis: a multivariate quantitative genetic analysis of hdl subfractions in two dietary environments. | we investigated dietary effects on pleiotropic relationships among 3 hdl cholesterol (c) subfractions (hdl1-c, hdl2-c, and hdl3-c; levels quantified by gradient gel electrophoresis) for 942 pedigreed baboons (papio hamadryas) who were fed a basal (chow) diet and a high cholesterol, saturated fat (hcsf) challenge diet. using multivariate maximum likelihood methods we estimated heritabilities for all 6 traits, genetic and environmental correlations (rhog and rhoe) between them, and the additive ge ... | 1999 | 10195946 |
| [cytogenetic characteristics t-lymphoid cell lines of hamadryas baboon (papio hamadryas)]. | | 1998 | 9825147 |
| a baboon (papio hamadryas) with an isochromosome for the long arm of the x. | a 5.5-yr-old female baboon was evaluated for sexual immaturity. she was small for her age and had normal external female genitalia. however, she lacked cyclical perineal turgescence and displayed atypical coloration of the perineal skin. laparoscopy revealed a small uterus and absence of both ovaries. cytogenetic analysis revealed a 42,x,i(x)(q10) karyotype. dna analysis using loci dxs1683, which maps to xp22.1, and dxs297, which maps to xq27.3, was consistent with inheritance of the normal x ch ... | 1998 | 9763665 |
| establishment of a method for analysis of chimerism in a baboon model (papio hamadryas) of islet/bone marrow transplantation. | | 1998 | 9532174 |
| male fights of hamadryas baboons | an attempt is made to develop a model of male fights which can account for the stylized facts, observed by kummer and his team, for hamadryas baboons. by two special versions of the general model it is shown that these observations can be consistently explained by one mathematical model which may deserve some interest for its own sake. to demonstrate the relative advantages of our approach we also analyse an ad hoc-type of model.copyright 1998 academic press limited copyright 1998 academic press ... | 1998 | 9473387 |
| effects of ketamine sedation on glucose clearance, insulin secretion and counterregulatory hormone production in baboons (papio hamadryas). | since the effects of ketamine sedation seem to differ between subspecies of baboons, we assessed the endocrine response to an intravenous glucose tolerance test (ivgtt) in 12 hamadryas baboons. the first phase insulin secretion, basal insulin, and glucose levels, as well as the glucose clearance, were significantly lower in sedated baboons as compared to fully awake animals. glucagon and cortisol were significantly higher, while growth hormone was lower during ketamine sedation. papio hamadryas ... | 1997 | 9438225 |
| phylogenetic analysis of a simian t lymphotropic virus type i from a hamadryas baboon. | | 1997 | 9390755 |
| ontogenetic changes in genetic regulation of fetal morphometrics in baboons (papio hamadryas subspp.). | it is known that different genes are expressed during ontogeny; however, it is unclear how variation in that expression is associated with changes in growth patterns. the objective of this study is to assess how genetic variation in fetal morphology changes with ontogeny in baboons. longitudinal measures of the head and femur (60 to 180 days gestation) were available for 892 pregnancies. we used a genetic model that allowed both the genetic and environmental variances (sigma 2g and sigma 2e) to ... | 1997 | 9353978 |
| genetics of adult body mass and maintenance of adult body mass in captive baboons (papio hamadryas subspecies). | adult body mass and changes in mass during an individual's life are important indicators of general health and reproductive fitness. therefore, characterization of the factors that influence normal variation in body mass has important implications for colony management and husbandry. the main objective of this study was to quantify the genetic contribution to adult body mass and its maintenance in baboons. intra-individual mean and variance in body mass were calculated from multiple weight measu ... | 1997 | 9261509 |
| changes of extracellular matrix in a baboon (papio hamadryas) model of insulin dependent diabetes: studies using electron microscopy and x-ray diffraction techniques. | extracellular matrix plays an important role in many physiological functions and its abnormalities are thought to play a key role in the pathogenesis of diabetic complications. in this paper we used the techniques of electron microscopy, immunostaining and x-ray diffraction to document some of the early events in the changes of extracellular matrix in a model of insulin dependent diabetes in baboons. our results show that thickening of basement membrane and enlargement of mesangium are demonstra ... | 1996 | 9031807 |
| a unique design for ease of access and movement of captive papio hamadryas. | baboons are widely used in biomedical research but their size and behaviour present potential problems with accessibility. a unique system has been developed that ensures ease of access to all animals in a colony of papio hamadryas. two distinct caging complexes were linked by a network of overhead races, that are connected to a physical restraint area where individual animals could be separated, restrained and weighed without being handled. access to and separation of individual family groups w ... | 1996 | 8938619 |
| reproductive and neonatal outcomes in captive bred baboons (papio hamadryas). | baboons are widely used in biomedical research. although it is widely held that papio hamadryas breed well in captivity, each established colony has a different reproductive success often hypothesised to be due to husbandry practices. the national baboon colony in australia is a unique colony that houses papio hamadryas to mimic that structure seen in the wild. in this article; we have analysed their reproductive parameters and neonatal outcomes. the success of the colony husbandry practices was ... | 1996 | 8906608 |
| cyclical changes in the renin-angiotensin-aldosterone system during the menstrual cycle of the baboon (papio hamadryas). | this study characterizes the renin-angiotensin-aldosterone system during the normal menstrual cycle in the baboon. ten animals received a daily dose of an ace inhibitor or placebo in a randomized blind cross-over design. data were obtained during the mid-follicular and early luteal phases of normal non-pregnant menstrual cycles. all examinations and blood collections were performed with ketamine sedation: 7-kg by im injection. blood pressure was recorded by sphygmomanometer. serum ace activity w ... | 1996 | 8906605 |
| the development of the baboon prostate: ultrasound methodology, modelling, and natural history. | in order to evaluate the potential of ultrasound for serial, nontraumatic estimation of prostate size in the hamadryas baboon (papio hamadryas), we adapted the technique of planimetric ultrasound to study a captive-bred colony of 30 male baboons (median age 8.4 years, range 3.3-17 years) including 4 long-term castrates. most (19) were studied on another two occasions (at 33-and 43-day intervals) to estimate reproducibility of the prostate size (dimensions, volume) measurement. prostatic dimensio ... | 2016 | 8889696 |
| low blood protein heterozygosity in zoo-bred hamadryas baboons. | an electrophoretic study of erythrocyte allozymes and serum proteins representing 32 genetic loci in 32 hamadryas baboons (papio h.hamadryas) from cologne and frankfurt zoos revealed biallelic polymorphism in phosphoglucomutase (pgm), mannose phosphate isomerase (mpi) and transferrin (tf). polymorphism amounted to p = 0.097 over 31 loci and observed heterozygosity to h(o) = 0.011, indicating significant reduction from the respective gene diversity parameters encountered in free-living hamadryas ... | 1996 | 8653592 |
| androgens regulate circulating levels of insulin-like growth factor (igf)-i and igf binding protein-3 during puberty in male baboons. | to examine the role of androgens in initiating the pubertal rise in circulating insulin-like factor-i (igf-i) levels, a longitudinal study of puberty in 13 male hamadryas baboons was conducted over 3 yr. the five control baboons commenced puberty (initial testicular enlargement) at a mean +/- se age of 4.2 +/- 0.4 yr. another eight baboons were castrated prepubertally; of those four received testosterone pellets (dose equivalent: 12.5-50 mg every 6 weeks) implanted se from the time of puberty. b ... | 1996 | 8550796 |
| effects of age, sex, and heredity on measures of bone mass in baboons (papio hamadryas). | bone mass and bone density were estimated in 219 pedigreed baboons (papio hamadryas) by radiographic morphometry of the left second metacarpal. compact bone width (total bone width--medullary canal diameter) and bone ratio (compact bone width/total bone width) decreased with increasing age squared in both sexes. the heritability of medullary canal diameter was 0.64 +/- 0.11, of compact bone width was 0.40 +/- 0.15 and of bone ratio was 0.67 +/- 0.13. the results indicate baboons are a useful mod ... | 1995 | 8750499 |
| [standardization of conditions for the evaluation of effectiveness of antibacterial drugs in pneumonic plague in sacred baboons]. | the signs of pneumonic plague in sacred baboons infected by aerosol are: fever, hurried breathing, depression and constantly increasing bacteremia. some infected animals isolate the plague microbes while coughing and thus could be a source of the infection. by the clinical and pathomorphological signs, pneumonic plague in sacred baboons is similar to that in humans which makes it possible to use the animals in the development of schemes for special prophylaxis and treatment of the disease. in ef ... | 1995 | 8593090 |
| a baboon (papio hamadryas) model of insulin-dependent diabetes. | over a period of four years, streptozocin has been used to induce diabetes in 10 baboons, all of whom are insulin dependent. we describe our experience with their husbandry, induction of diabetes, insulin therapy, metabolic control and growth rate. streptozocin dosage of 60 mg/kg readily induces hyperglycemia with minimal hepatic or renal toxicity. using a once daily injection of mixed short and intermediate acting insulins at a dosage of 2-4 u/kg, it is possible to maintain a degree of metaboli ... | 1995 | 7563008 |
| establishment and characteristics of an interleukin-2-dependent stlv-1-producing lymphoid cell line, sph-7(t), obtained from papio hamadryas with malignant lymphoma. | | 1994 | 7842161 |
| fetotoxicity of angiotensin-converting enzyme inhibition in primate pregnancy: a prospective, placebo-controlled study in baboons (papio hamadryas). | serious concerns have been raised about angiotensin-converting enzyme inhibition in pregnancy. the central question remains: does toxicity of angiotensin-converting enzyme inhibition pertain to pregnant humans? | 1994 | 8092208 |
| haemodynamic actions of a nitric oxide (edrf) synthesis inhibitor in conscious baboons (papio hamadryas). | 1. the haemodynamic effects of intravenous nitric oxide inhibitor, n-nitro-l-arginine (nola), were examined in four conscious non-restrained baboons (papio hamadryas). mean arterial pressure, (map), systemic vascular resistance (svr) and cardiac output (co) were measured at timed intervals up to 24 h after a bolus injection of nola. 2. n-nitro-l-arginine increased blood pressure in a dose-dependent manner up to 9.5 mg/kg. increases in blood pressure were accompanied by increases in svr and decre ... | 1994 | 7529664 |
| biochemical heterozygosity and morphologic variation in a colony of papio hamadryas hamadryas baboons. | this analysis examines the association between genetic heterozygosity and individual morphologic variation in a captive population of papio hamadryas hamadryas consisting of 403 juveniles and adults. the population structure of the colony was artificially generated and maintained and is thus rigorously defined. subpopulations delimited by age, sex, and degree of inbreeding are also explored. heterozygosity, as enumerated from six simple mendelian biochemical loci, is compared with the residual m ... | 1994 | 28564474 |
| effect of protein diets on the renal function of baboons (papio hamadryas) with remnant kidneys: a 5-year follow-up. | to assess the progression of renal disease and the effects of protein intake in a species phylogenically close to humans, 14 adolescent baboons (papio hamadryas) were subjected to infarction of one third of the left kidney and, 2 months later, to right nephrectomy. they were then randomized to a synthetic protein diet containing either 8% or 25% casein. hemodynamic and metabolic measurements were obtained in awake animals every 4 months. modest proteinuria developed immediately after left kidney ... | 1994 | 8311075 |
| integrating behavior and cardiovascular responses: posture and locomotion. i. static analysis. | heart rate, arterial blood pressure, and renal and mesenteric or femoral blood flow were telemetered from 11 papio hamadryas in an untethered free-ranging situation. the animals' behavior was recorded on videotape, and the cardiovascular (cv) data were recorded on the audio channels of the tape. the behavior was coded, and the codes were linked to the cv data via a time-code generator and computer control. the cv data were digitized into 1-s intervals, and the static relations between cv measure ... | 1993 | 8285290 |
| cross-sectional growth standards for captive baboons: ii. organ weight by body weight. | we present the first cross-sectional organ weight by body weight reference standards for captive baboons (papio hamadryas). organ weight data were obtained from necropsy reports for 634 healthy, pedigreed, captive female and male baboons. from summary statistics we calculated and fit cross-sectional sex-specific percentile curves for: adrenals, brain, eyes, heart, kidneys, liver plus gall bladder, lungs, pancreas, pituitary gland, spleen, and thyroid gland in three kilogram body weight intervals ... | 2007 | 8169944 |
| cross-sectional growth standards for captive baboons: i. organ weight by chronological age. | we present the first cross-sectional organ weight reference standards for captive baboons (papio hamadryas). organ weight data were obtained from necropsy reports for 634 healthy, pedigreed, captive female and male baboons. from summary statistics we calculated and fit cross-sectional, sex-specific percentile curves for: adrenals, brain, eyes, heart, kidneys, liver plus gall bladder, lungs, pancreas, pituitary gland, spleen, and thyroid gland in two year age class intervals and summary statistic ... | 2007 | 8169943 |
| x-linked glucose-6-phosphate dehydrogenase (g6pd) and autosomal 6-phosphogluconate dehydrogenase (6pgd) polymorphisms in baboons. | electrophoretic polymorphisms of glucose-6-phosphate dehydrogenase (g6pd) and 6-phosphogluconate dehydrogenase (6pgd) were examined in captive colonies of five subspecies of baboons (papio hamadryas). phenotype frequencies and family data verified the x-linked inheritance of the g6pd polymorphism. insufficient family data were available to confirm autosomal inheritance of the 6pgd polymorphism, but the electrophoretic patterns of variant types (putative heterozygotes) suggested the codominant ex ... | 1992 | 1296572 |
| endometriosis and stromal tumor in a baboon (papio hamadryas). | | 1992 | 1318457 |
| inhibitory and excitatory amino acid receptors, c-fos expression, and calcium-binding proteins in the brain of baboons (papio hamadryas) that exhibit 'spontaneous' grand mal epilepsy. | | 1992 | 1363039 |
| linkage of plasminogen (plg) and apolipoprotein(a) (lpa) in baboons. | four allelic forms of serum plasminogen (plg) were detected in baboons (papio hamadryas linneaus 1758) by isoelectric focusing and were determined to be inherited as autosomal codominant traits. linkage analysis of data from 179 progeny and their parents revealed that plg is tightly linked (lod score = 30.20) to the gene encoding apolipoprotein(a) (lpa), as in humans. no recombinant individuals were identified. this is the first linkage detected between plg and lpa in any species other than huma ... | 1991 | 1783400 |
| integrating behavior and cardiovascular responses: the code. | the next revolution in biology is predicted to be in the integrative domain, and the need to involve physiologists in this kind of research has been recognized. this paper represents an approach to providing some of the tools required for dealing with integrative physiology at the behavioral level. video tape recordings are made of the activities of a group of five baboons (papio hamadryas) while simultaneous recordings of arterial blood pressure, heart rate, renal blood flow, and mesenteric or ... | 1991 | 1858945 |
| [regeneration of the function of the hypophyseal-gonadal system after its prolonged suppression with luliberin agonists]. | the paper is concerned with the results of investigation into the nature of regeneration of function of the hypophyseo-gonadal system in 15 mature male papio hamadryas, subjected to infusion of lh-rh agonists (buserelin, hoechst a. g. germany) and surfagon (all-union cardiology research center, ussr) using osmotic mini-pumps (alzo corp., palo alto, usa) for 5-16 weeks. regeneration of this system was characterized by 3 main phases: latent; gonadal hyperfunction and return to the basal level of f ... | 2016 | 1658774 |
| variation in lp(a) levels and apo(a) isoform frequencies in five baboon subspecies. | elevated levels of lipoprotein (a) [lp(a)] are positively correlated with risk of cardiovascular disease and are thought to be a function of allelic variation in apo(a), the unique protein component of lp(a). in this article we examine subspecies variation in lp(a) levels and apo(a) isoforms in the baboon. breeding populations of the five subspecies (papio hamadryas hamadryas, p.h. cynocephalus, p.h. ursinus, p.h. papio, and p.h. anubis) of common long-tailed baboons are maintained at the southw ... | 1991 | 2004745 |
| hemodynamics of conscious unrestrained baboons, including cardiac output. | a method is described for comprehensive hemodynamic study of undisturbed baboons (papio hamadryas) that incorporates cardiac output measurement by thermodilution. instrumentation includes arterial, aortic, and central venous catheterization by a surgical technique that does not require entry to peritoneal or thoracic cavities. it provides a means for right atrial indicator delivery with aortic temperature recording of thermodilution curves. accuracy was confirmed by comparison to measurement by ... | 1990 | 2384419 |
| an outbreak of botulism in captive hamadryas baboons (papio hamadryas). | | 1990 | 2316161 |
| [hormonal reaction of steroid-producing glands of female papio to long-term hypokinesia]. | the endocrine function of steroid-producing glands of hamadryas baboon females exposed to 28-day clinostatic hypokinesia at different stages of the menstrual cycle was investigated. the adrenocortical response to hypokinesia developed in two phases: early stimulation was followed by inhibition of the adrenocortical activity which persisted during the subsequent period of hypokinesia and two weeks after exposure. the degree and duration of the activation effect of hypokinesia were determined by t ... | 2013 | 2366502 |
| [the role of acth in regulating dehydroepiandrosterone secretion in primates]. | the effect of repeated administration of a prolonged acth agent on the secretion of glucocorticoids, dehydroepiandrosterone (dea) and delta 4- and delta 5-precursors was studied in experiments on male hamadryas baboons. the administration of sinacten-depot at a dose of 1 mg for 5 days caused a noticeable decrease in the basal levels of cortisol, 11-deoxycortisol, pregnenolone, 17-oxypregnenolone, and dea. response of the adrenal glands to additional acth stimulation against a background of lower ... | 2016 | 2158657 |
| [infanticide in hamadryas baboons]. | the results of 20-year study of infanticide cases in hamadryas baboon troop of the sukhumi colony and 10-year observations in gumista natural reserve are presented. the allopatric behaviour which may be the cause of infant death, is shown to be common for 4-7 year old males. in behaviour of older males directed to the infants the elements of aggression predominate. the majority of injuries and infanticide by males takes place in the situations associated with a dominant male change in the group ... | 1990 | 2142606 |
| [the adrenocortical function of female hamadryas baboons under prolonged hypokinesia]. | the paper is concerned with the results of a study of hormonal function of the adrenocortical system of female papio hamadryas during 28-day clinicostatic hypokinesia which started at various phases of the menstrual cycle. a 2-phase response of the investigated system to prolonged hypokinesia was established. the activation of corticosteroid secretion on the 1st day of hypokinesia was changed further on by the inhibition of adrenocortical endocrine function. the intensity and duration of activat ... | 2016 | 2622888 |
| [polymorphism of the response of the hypophyseo-gonadal system to the long-term administration of an agonist of luliberin]. | the paper is concerned with the results of experiments on male papio hamadryas aimed at the investigation of their hypophyseal and gonadal endocrine function by intravenous drip with the help of subcutaneously implanted osmotic mini-pumps of buzerelin, a superactive lh-rh analog. a 2-phase response of the hypophyseal-gonadal system was revealed. the stimulation of the secretion of lh and testicular androgens in the first 5-7 days of buzerelin administration was followed by sharp suppression of g ... | 2016 | 2500654 |
| [opposite changes of social behavior in hamadryas baboons after administration of mediators of cellular and humoral immunity--thymosine and myelopeptides]. | | 1989 | 2583003 |
| [acclimatization of hamadryas baboons on the black sea coast of the caucasus: their territorial behavior]. | the territorial behaviour of hamadryas baboon troop was studied from november 1984 up to february 1986. the observations were carried out from the time of animals' awakening till their arrangement for a night sleep using the method of daily tracking with recording to behavioural action frequency for all visible animals with definite intervals. it has been established that the size of habitat ranges depends on food resources. the travels across the territory has a seasonal nature. | 1989 | 2532935 |
| [structural and functional anomalies of the cellular proto-oncogenes in malignant lymphomas in hamadryas baboons]. | | 1987 | 3502217 |
| [social rank, its determinative factors and reproductive indices of female hamadryas baboons]. | | 1987 | 3424962 |
| [experience in the breeding of free-living hamadryas baboons on the black sea coast of the caucasus]. | | 1987 | 2962388 |
| [somatotypes and the productivity of female hamadryas baboons of reproductive age]. | | 1987 | 2962387 |
| circulatory adaptation to pregnancy--serial studies of haemodynamics, blood volume, renin and aldosterone in the baboon (papio hamadryas). | to test the hypothesis that haemodynamic changes in pregnancy precede any significant increase in circulating blood volume, serial haemodynamic studies were performed in eight baboon pregnancies using swan-ganz catheterization and arterial cannulation. simultaneous measurements were made of red cell and plasma volumes, and of plasma renin activity and aldosterone concentration. haemodynamic changes identified by 4 weeks gestation included significant (p less than 0.01) reductions in right atrial ... | 1986 | 3546496 |
| corticosteroid circadian rhythms in female hamadryas baboons under prolonged hypokinesia. | | 2017 | 3796806 |
| [circadian rhythm of progesterone, estradiol and dehydroepiandrosterone in the pregnant papio hamadryas]. | | 1986 | 2944417 |
| [circadian rhythms of the corticosteroid concentration during pregnancy in hamadryas baboons]. | | 1986 | 3717514 |
| [effect of prolonged hypokinesia on the gonadal and adrenal function of female hamadryas baboons]. | a radioimmunoassay was used to study the effect of 26-day clinostatic hypokinesia on the level of sex hormones and cortisol in the peripheral blood plasma of 10 female papio hamadryas immobilized in different phases of the menstrual cycle. a significant decrease in the level of estradiol in the follicular phase and progesterone in the luteal phase was shown whereas the levels of cortisol and testosterone did not practically vary. dependence of the adrenal gland reactivity to an acute immobilizat ... | 2016 | 3952076 |
| [endocrine function of the testes in experiments on papio hamadryas]. | | 1986 | 3705723 |
| [reproductive function of papio hamadryas living freely in an animal preserve]. | | 1986 | 3705716 |
| [effect of adrenocorticotropic hormone on the secretory activity of the gonads and adrenals of male hamadryas baboons]. | the time course of the secretion of steroid hormones to the adrenal and seminal veins following administration of synthetic acth was studied in experiments on mature male hamadryas baboons. testosterone, 5 alpha-dihydrotestosterone, androstendion, 17-oxyprogesterone and 17-oxypregnenolone levels in the venous blood were determined by means of radioimmunoassays with preliminary chromatographic isolation of steroids on cellite. the rate of hormone secretion by the adrenal and seminal glands was ca ... | 2016 | 3006020 |
| [beta-endorphin-like immunoreactivity of the blood plasma of hamadryas baboons and its changes]. | it was established that plasma level of beta-endorphin-like ir in baboons (papio hamadryas) was 8 +/- 1 fm/ml, and of beta-lipoprotein-like ir- 9 +/- 1 fm/ml. ratio between beta-endorphin-like and beta-lipoprotein-like ir was 0.9 +/- 0.1. under the electrical stimulation of the periventricular-perifornical area of hypothalamus, the level of beta ep-ir reached 26 +/- 9 fm/ml while the level of beta lp-ir fell. on the mamillary hypothalamic area stimulating, no similar changes were observed. a con ... | 1985 | 2934100 |
| [androgen content of the blood of male hamadryas baboons over the course of a year]. | annual blood plasma levels of testosterone, 5 alpha-dehydrotestosterone and dehydroepiandrosterone were measured in hamadryas baboon males using radioimmunoassay. fluctuations characterized by a decrease in testosterone and 5 alpha-dehydrotestosterone concentrations in spring and an increase in their levels in autumn have been established. dehydroepiandrosterone level was characterized by two minimal points--at the beginning of the year and in august. the following average annual levels of andro ... | 1985 | 2934099 |
| [functional activity of the adrenal system in relation to the hierarchical status of male hamadryas baboons in an isolated group]. | the correlation between hormonal activity of hypophysis-gonad system and hierarchical status of hamadryas baboon males in an isolated group was studied. it has been established that the level of testosterone was higher in males occupying the leading position in a separate subgroup. a high level of sexual hormone was observed in animals with greater muscular mass and age. no correlation between hierarchical status and luteinizing hormone blood content has been observed in baboon males. | 1985 | 4063492 |
| [analysis of reproductive indices of a hamadryas baboon colony in the sukhumi nursery]. | | 2006 | 2934911 |
| [effect of acth on the corticosteroid and progesterone levels in female hamadryas baboons in relation to the menstrual cycle phase]. | the effect of exogenous acth on the endogenous function of the steroid-producing glands has been investigated in hamadryas baboon females depending on the level of sex hormones in the body. the content of corticosteroids and progesterone in peripheral blood plasma was measured by radioimmunoassay. it has been established that the time course of changes in the adrenal gland response to administration of a standard acth dose was of the same type in the different menstrual cycle phases. the inhibit ... | 1985 | 2992627 |
| [effect of gonadectomy and luliberin on the gonadotropic function of the hypophysis in papio hamadryas]. | a comparative study was made of the effect of lh-rh on the hypophyseal reactivity in intact and castrated male papio hamadryas. hypophysis gonadotropic function was evaluated by the content of the biologically active luteinizing hormone in the peripheral blood plasma which was determined by an in-vitro biological method. bilateral gonadectomy caused an increase in the luteinizing hormone concentration by an average of 600% in this species of apes. the hormone level got stable at maximum values i ... | 2016 | 3900981 |
| physiological sleep myoclonus in baboons. | physiological sleep myoclonus (sleep onset myoclonus and myoclonus during paradoxical sleep) was recorded from the tails of 6 baboons (2 papio hamadryas and 4 papio papio) and its relationship with spontaneously occurring eeg paroxysmal discharges was studied. it was observed that during light slow wave sleep tail myoclonus (sleep onset myoclonus) was almost always associated with eeg paroxysmal discharges predominating in the fronto-rolandic cortex. during deep slow wave sleep the number of eeg ... | 1985 | 2578368 |
| [circadian rhythm of corticosteroids in female hamadryas baboons during long-term hypokinesia]. | radioimmunoassay was used to study the effect of restricted motor activity on the circadian rhythms of the content of hydrocortisone, 11-deoxycortisol, corticosterone and aldosterone in the blood plasma of mature female hamadryas baboons in different phases of the menstrual cycle. intact animals demonstrated distinct circadian rhythms of corticosteroids reproduced stably in both phases of the cycle. two-week immobilization did not change the general nature of rhythms of the content of glucocorti ... | 2016 | 4039062 |
| [chromosome analysis of female baboons following treatment with sts 557 and levonorgestrel]. | adult, female baboons (papio hamadryas) were administered orally once 18 h p.c., either 1.6 mg sts 557 (17 alpha-cyanomethyl-17 beta-hydroxy-estra-4;9(10)-dien-3-one) or 1.6 mg levonorgestrel. investigations of the bone-marrow cells of these animals showed, compared to untreated controls, no signs of increased chromosome aberrations caused by the substances. the relative frequency of chromosome aberrations were estimated for controls: sts 557: levonorgestrel with 0.60 +/- 0.35 : 0.55 +/- 0.39 : ... | 1985 | 3922162 |
| endometriosis with bacterial peritonitis in a baboon. | an adult female papio hamadryas being used in reproductive studies was found moribund unexpectedly. palpation revealed acute abdominal pain and a pelvic mass. a tentative diagnosis of endometriosis and shock was made. necropsy and histological examination confirmed the diagnosis of endometriosis and identified an associated bacterial peritonitis. | 1984 | 6513512 |
| conservation of blood plasma fluids in hamadryas baboons after thermal dehydration. | after 2 days of water deprivation in a warm climate, papio hamadryas baboons lost 10% of their body mass, 12.5% of their total body water (3h2o) space, but only 4% of their plasma volume [evans blue (eb) space]. hematocrit and hemoglobin concentration as well as blood viscosity and blood pressure were not affected by thermal dehydration. plasma colloid osmotic pressure (cop) in the dehydrated animals was, however, 8 torr higher than in fully hydrated baboons. total mass and concentration of plas ... | 1984 | 6490462 |
| [circadian rhythms of the sex steroids of female papio hamadryas in long-term hypokinesia]. | radioimmunoassay was used to study the effect of restricted motor activity on circadian rhythms of blood plasma sexual steroids and cortisol in female papio hamadryas during different phases of the menstrual cycle. instact animals manifested clear-cut circadian rhythms of the testosterone and cortisol content during both the phases and those of estradiol and progesterone during the follicular phase of the cycle. two-week immobilization did not produce any changes in the general pattern of circad ... | 1984 | 6487794 |
| increased antibody responses to herpes virus papio (hvp) antigens in pre-lymphomatous baboons (papio hamadryas) of the sukhumi high lymphoma stock. | antibody responses to herpes virus papio (hvp) antigens were studied in 21 pre-lymphoma baboons (which subsequently died of malignant lymphoma), 21 paired controls, i.e. age-, sex- and population-matched healthy baboons, and 185 randomly selected healthy baboons of the same population. the sera were all collected at the same time and were tested blind in the fixed-cell indirect immunofluorescence test against hvp viral capsid antigen (vca)-positive, early antigen (ea)-positive cell targets befor ... | 1983 | 6642757 |