| monocular nystagmic responses to caloric stimulation. | twenty-five normal subjects and 173 clinical patients received standard bithermal caloric testing. vestibular nystagmus was evaluated for cumulative slow phase velocity from the summated horizontal eye recording and independent recording of the left and right eye. these data revealed that cold water stimulation produced more intense activation of the ipsilateral eye. simultaneous closed-circuit video and d.c. electro-oculographic recordings from eight normal rhesus monkeys in response to cold wa ... | 1979 | 106760 |
| vestibular effects of electrical stimulation of the cochlea. monitored in the awake primate. | the effect of electrical stimulation of the cochlea on vestibular response was monitored in six rhesus monkeys. eye movements and single-unit activity from the vestibular portion of the eighth nerve, vestibular nuclei, reticular formation, and abducens nucleus were observed while electrical stimulation was delivered through an implanted cochlear prosthesis. in one animal of this series, neural activity from the inferior colliculus and cochlear nuclear complex was also recorded. electrical stimul ... | 1979 | 106814 |
| ebola virus: a comparison, at ultrastructural level, of the behaviour of the sudan and zaire strains in monkeys. | histopathological and electron microscopical examination of human liver specimens collected during the ebola haemorrhagic fever outbreaks in zaire and sudan indicated that zairean strains of the virus produced more extensive lesions. experimental infection of rhesus monkeys wiht zairean and sudanese strains of ebola virus produced similar changes to those found in man. in zairean strain infections large numbers of virus particles were found in the liver, lung and spleen accompanied by extensive ... | 1978 | 106868 |
| use of molecular hybridization to detect type d retrovirus markers in rhesus placentas and other tissues. | we have shown previously that approximately 20% of the mason-pfizer virus (mpv) genome is present as endogenous provirus in rhesus monkeys. we report here that several full-term rhesus placentas examined contain additional mpv proviral sequences in their dna. competitive molecular hybridization experiments demonstrated that some of these placentas also contain rna complementary to the entire mpv 60 to 70s rna genome. examination of internal organs of rhesus monkeys captured in the wild also reve ... | 1979 | 106962 |
| serum estradiol, testosterone and dihydrotestosterone in male monkeys treated with testosterone propionate. | serum estradiol (e2), testosterone (t) and dihydrotestosterone (dht) were measured in juvenile (pre-pubertal) male rhesus monkeys injected with either 8 mg or 80 mg of testosterone propionate (tp). after one week, the three steroids were elevated and remained essentially unchanged for the duration of the study. there was little difference in serum e2 or dht when comparing the two groups of steroid-treated monkeys. in contrast, t levels were consistently greater in the animals given the high dosa ... | 1978 | 107019 |
| advanced trauma life support laboratory: pilot implementation and evaluation. | selected invasive diagnostic and therapeutic techniques were taught to emergency physicians through modular advanced trauma life support (atls) animal laboratory courses presented in the fall of 1977. thirty-seven emergency physicians participated in the four pilot atls laboratories in which the average trainee:animal:instructor ratio was 2:1:0.75. the animals consisted of 15 large baboons and five large rhesus monkeys. cost accounting on these pilot atls courses revealed that the total program ... | 1979 | 107357 |
| association of tritium-labelled estradiol, progesterone and 17 alpha-hydroxyprogesterone with the proteins of the serum and cerebrospinal fluid in the rhesus monkey. | the electrophoretic profiles of the proteins in the serum and cerebrospinal fluid (csf) of the rhesus monkey were studied by polyacrylamide gel electrophoresis. the association of tritium labelled estradiol (3h-e), progesterone (3h-p) and 17 alpha-hydroxyprogesterone (3h-17ohp) with these proteins was studied under in vitro and in vivo conditions. the csf was found to contain, besides albumin, at least 4 globulins with similar electrophoretic mobilities as those found in the serum. the electroph ... | 1979 | 107466 |
| antigenic analysis of sequential erythrocytic stages of plasmodium knowlesi. | the antigenic composition of sequential erythrocytic stages of plasmodium knowlesi has been compared by crossed immuno-electrophoresis using a pool of immune rhesus monkey antiserum. eleven major parasite antigens have been identified; 9 are stage-independent, and 2 stage-dependent. differences in the relative amount of the stage-independent antigens have been demonstrated and quantified. the distribution of antigens between parasites and schizont and infected red cell membranes has been examine ... | 1978 | 107503 |
| sham feeding in the rhesus monkey. | | 1978 | 107536 |
| inhibition of gonadotropin by delta9-tetrahydrocannabinol:mediation by steroid receptors? | competition assays for estradiol receptors in cytosol preparations of uteri from rhesus monkeys and humans showed that delta9-tetrahydrocannabinol (thc) does not compete with estradiol for intracellular estrogen recptors. although isotopically labeled thc bound to macromolecules in uterine cytosol from the rhesus monkey, the binding was not displaced by unlabeled thc, diethylstilbestrol, estradiol, progesterone, cortisol, or 5 alpha-dihydrostestosterone. scatchard analyses indicated that high-af ... | 1979 | 107589 |
| ischemic brain edema: comparative effects of barbiturates and hypothermia. | the effect of pentobarbital and hypothermia on the development of ischemic brain edema was studied in 23 rhesus monkeys undergoing transorbital middle cerebral artery occlusion. fifteen additional animals served as unclipped controls. regional cortical cerebral blood flow (rcbf), arteriovenous oxygen content difference (avdo2), and regional cortical metabolic rate of o2 (rcmro2) were measured hourly until sacrifie 11 hours postocclusion, at which time ischemic cerebral edema was measured. in 8 a ... | 1979 | 107624 |
| effect of rabbit anti-human thymocyte globulin on lymphocyte subpopulations and functions following allotransplantation in the rhesus monkey. | the survival time of skin allografts from rhla-nonidentical, unrelated donors was increased from a mean of 7.69 days in controls (n = 20) to a mean of 32.53 days in rhesus monkeys (n = 21) receiving a total dose of 250 mg of rabbit anti-human thymocyte globulin (ratg) per kg. immunological monitoring studies were performed on the peripheral blood of mononuclear cells in control and treated monkeys. after administration of ratg, the percentage of e rosette-forming cells (e-rfc) was greater than 9 ... | 1979 | 107631 |
| [hydrolysis and the inactivation of double-stranded polyribonucleotides by monkey blood serum]. | the effect of macaca rhesus monkey blood serum on double-stranded polyribonucleotide complexes poly (i).poly (c), poly (g).poly (c), and poly (g,i).poly (c) was studied. the poly (i).poly (c) complex was found to be the most sensitive to hydrolysis as indicated by a decrease of the molecular weight, accumulation of acid-soluble products and a sharp decline of the antiviral and interferon-inducing activities in tissue culture after incubation of the complex in the presence of the serum at 37 degr ... | 1979 | 107655 |
| terminal course of nerve supply to müller's muscle in the rhesus monkey and its clinical significance. | electron microscopic, histochemical fluorescence, and pharmacologic evidence suggested that, in the rhesus monkey, müller's muscle was not totally denervated either by cutting the levator palpebrae superioris muscle or by a fasanella-servat procedure. we examined the terminal course of the sympathetic nerve supply and the potential for preserving müller's muscle in blepharoptosis surgery. | 1979 | 107804 |
| mechanism of induction of lh surge in the rhesus monkey: positive feedback of estrogen? | | 1979 | 107813 |
| medroxyprogesterone acetate: peripheral serum levels and its effects on pituitary and ovarian functions in the rhesus monkey. | 17 alpha-acetoxy-6 alpha-methylprogesterone (medroxy-progesterone acetate, mpa) in doses of 50 mg followed 4 weeks later by an additional 100 mg was i.m. injected in 5 adult normal female monkeys. serum levels of mpa, progesterone, estradiol-17-beta and lh were determined every other day for a period of 8 weeks then weekly for 8 months. peak values of serum mpa were detected 2 weeks postinjection followed by a gradual decline to undetectable levels after variable periods ranging from 125 to 225 ... | 1978 | 107956 |
| opioids: similarity between evaluations of subjective effects and animal self-administration results. | abuse potential studies of 33 morphine-like analgesics were compared in humans and monkeys. the results of intravenous self-administration studies in rhesus monkeys were correlated with measures of morphine-like signs, symptoms, and subjective effects in ex-addicts. each set of data was assigned to a position in a 3 x 3 contingency table dependent upon whether the results were yes, no, or equivocal. of the 33 drugs, 29 were given identical classifications in both the human and animal test proced ... | 1979 | 108042 |
| immunogenecity of hapten-protein conjugates in rabbits and monkeys preimmunized against the carrier protein. | the effect of preimmunization with carrier protein on the subsequent response to immunization with hapten-protein conjugate was investigated. rabbits immunized against bovine serum albumin (bsa) showed a delay in the production of anti-progesterone antibodies upon immunization with progesterone-11-bsa. after a booster injection with p-11-bsa, however, they achieved antiprogesterone levels comparable to those in animals immunized with p-11-bsa only. similarly, rhesus monkeys preimmunized with tet ... | 1978 | 108046 |
| evidence for alterations in luteinizing hormone secreted in rhesus monkeys with normal and inadequate luteal phases using radioreceptor and radioimmunoassay. | | 1979 | 108090 |
| prolactin concentrations in the monkey fetus during the last third of gestation. | prl concentrations were measured in cord plasma obtained at hysterotomy from 26 rhesus monkey fetuses between 111--170 days gestational age (ga). mean prl concentrations increased significantly from 23.7 +/- 10.1 (x +/- se) ng/ml at 121--130 days ga to 126.9 +/- 16.9 ng/ml at 161--170 days ga. a similar significant increase in prl with age also was observed in samples obtained from 16 fetuses chronically catheterized in utero between 130--155 days ga. mean prl levels were 34 +/- 3.2 ng/ml at 131 ... | 1979 | 108091 |
| estrone, 17 beta-estradiol, and cortisol in serum of peripartum rhesus monkeys. | | 1979 | 108092 |
| visual cortex ablation and thresholds for successively presented stimuli in rhesus monkeys: ii. hue. | rhesus monkeys were trained to discriminate successively presented hues. the smallest difference they could reliably detect was determined before and after either inferotemporal ablation, or a lesion intended to remove as much as possible of prestriate area v4 (zeki, 1973). as a group, the animals with lesions of v4 showed good but not perfect retention of their preoperative performance, and their thresholds were unaltered. the inferotemporal group showed no retention of the simplest successive ... | 1979 | 108121 |
| responses of single units in the monkey superior colliculus to stationary flashing stimuli. | 1. responses of pan-directional cells in the superficial layers of the superior colliculus in paralysed anaesthetized rhesus monkeys to stationary flashing stimuli have been studied. 2. the receptive field centre response is always of the transient excitatory on-off type, while the surround response is transient inhibitory both at light-on and at light-off. the receptive field centres are circular or slightly elliptical. the average size of the receptive field centres is much larger than that of ... | 1979 | 108123 |
| responses of single units in the monkey superior colliculus to moving stimuli. | 1. single unit responses of pan-directional cells to moving and stationary flashing stimuli were studied in the superficial layers of the superior colliculus in paralysed, anaesthetized rhesus monkeys. the aim of this study was to see how far cell responses to moving stimuli fit in with what would be expected from their responses to stationary flashing stimuli. 2. both the leading and the trailing edge of a moving stimulus evoke a transient response. if the diameter of moving light spots is incr ... | 1979 | 108124 |
| effects of sensorimotor eeg feedback training on seizure susceptibility in the rhesus monkey. | | 1978 | 108125 |
| effect of hyperextension-hyperflexion (whiplash) on the function of the blood-brain barrier of rhesus monkeys. | | 1979 | 108126 |
| the immobilization response in rhesus monkey: a behavioral and electroencephalographic study. | | 1979 | 108127 |
| effect of tetrahydrocannabinol on the hypothalamic-pituitary axis in the ovariectomized rhesus monkey. | single doses of delta9-tetrahydrocannabinol (thc) (5.0, 2.5, 1.25, or 0.625 mg/kg) can decrease the levels of both luteinizing hormone (lh) and follicle-stimulating hormone (fsh) in the ovariectomized rhesus monkey. the inhibition of gonadotropins (50% to 88%) lasts for 6 to 24 hours depending upon the dose of thc. there are no great differences in the responses of the two gonadotropins to thc. the inhibition of gonadotropin levels by thc appears to be at the level of the hypothalamus, since bot ... | 1979 | 108139 |
| sexual behavior and hormone levels during the menstrual cycles of rhesus monkeys. | | 1978 | 108191 |
| estimation of the intravascular half-lives of normal rhesus monkey igg, iga and igm. | rhesus monkey igg, iga and igm were purified from pooled normal serum and labelled with 125i. four monkeys were injected intravenously with approximately 50 microgram of each purified immunoglobulin containing between 25 muci and 50 muci of 125i. iodination was approximately 1 atom per 14 molecules of igg and iga and per 2.5 molecules of igm. samples of serum were taken for up to 22 days after injection and radioactivity compared with that in a sample taken within 30 min of injection. sucrose de ... | 1979 | 108203 |
| factors influencing plasma cortisol (11-hydroxycorticoids) levels in rhesus monkeys. | | 1978 | 108211 |
| observation on the mucosa of the fallopian tube of immature rhesus monkey macaca mulatta. | | 1978 | 108215 |
| human t cell receptors for monkey erythrocytes. | to test the specificity of t cell receptors, erythrocytes and lymphocytes of man and rhesus monkey (macaca mulatta) and erythrocytes of sheep were mixed in four different combinations to observe the rosette formation. during the study, a major proportion of human t cells formed spontaneous rosettes with the erythrocytes of rhesus monkey. a small number of monkey lymphocytes formed rosettes with human group o rh-negative cells while t cells both of man and rhesus monkey formed rosettes with sheep ... | 1979 | 108224 |
| repair and late degeneration of the primate foveola after injury by argon laser. | each foveola of nine rhesus monkey eyes was subjected to a single, mild, calibrated exposure from an argon laser (1 to 1.4 mw for 10 to 20 min). observations from ophthalmoscopy, fundus photography, and fluorescein angiography were correlated with light and electron microscopic studies. the ophthalmoscopic changes consisted of initial whitening and subsequent but persistent depigmentation of the foveola. fluorescein angiography showed a pattern consistent with "window defect" of the retinal pigm ... | 1979 | 108229 |
| the effects of short-term experimental strabismus on the visual system in macaca mulatta. | experimental esotropia was produced surgically in infant rhesus monkeys (macaca mulatta) for brief periods of time. electrophysiological studies of the visual cortex showed that esotropia of only 2 weeks duration in an infant monkey is sufficient to cause a marked shift of dominance in favor of the fixating eye and to virtually extinguish cortical neuronal responses from the esotropic eye. in the lateral geniculate nucleus cell (lgn), shrinkage of 6% to 8% occurred in the parvocellular layers co ... | 1979 | 108230 |
| the effect of pneumatic tourniquets on the ultrastructure of skeletal muscle. | experiments have been carried out on rhesus monkeys to determine the effect of the application of a pneumatic tourniquet on the ultrastructure of the muscles of the lower limb. tourniquets were applied for periods lasting between one and five hours. the changes in the muscle lying immediately under the cuff of the tourniquet were more marked than those observed in muscle distal to the cuff. three hours appears to be close to the limit of the time that a muscle can resist the sustained compressio ... | 1979 | 108286 |
| aging in the rhesus monkey: effects on visual discrimination learning and reversal learning. | the behavior of aged rhesus monkeys (18 years and older) was compared to that of young monkeys (3 to 6 years old) to evaluate their relative abilities to learn a series of visual discrimination and discrimination reversal problems. using a subject-paced, automated experimental procedure designed to optimize stimulus control and facilitate execution of choice responses, no consistent age-related differences were observed in the ability to learn new color and pattern discrimination problems of var ... | 1979 | 108323 |
| biosynthesis of glycosylated hemoglobins in the monkey. | we have investigated the in vivo biosynthesis of the minor hemoglobin components in the rhesus monkey. the elution profile of rhesus hemolysate on biorex 70 cation exchange resin was analogous to that of human hemolysate. the rhesus hb alc peak was identified with the tba test, which revealed a carbohydrate content identical to that of human hb a1c. a rhesus monkey was injected with autologous 55fe-bound transferrin, and the specific activity of each of the minor and major components was followe ... | 1979 | 108346 |
| reproductive capacity of rhesus monkeys following bilateral ovarian x-irradiation. | the effect of ovarian x-irradiation of the rhesus monkey upon menstrual cycle length, duration of menstrual bleeding, excretion of gonadotrophin in the urine, concentration of gonadotrophin in the pituitary gland, ovarian histology, and breeding performance was investigated. doses below 4000 r had no significant effect upon the above criteria. by contrast, doses of 4000 to 7000 r rapidly induced amenorrhoea in most animals, but unexpectedly these animals did not excrete greater than normal amoun ... | 1979 | 108398 |
| comparison of ketmine with the combination of ketamine and xylazine for effective anesthesia in the rhesus monkey (macaca mulatta). | the addition of xylazine to ketamine hydrochloride was found to enhance analgesia, anesthesia, and muscle relaxation in rhesus monkeys. at 0.10 ml/kg body weight, this combination provided adequate anesthesia for such procedures as cisternal puncture, lumbar spinal puncture, insertion of urinary catheters, finger amputations, and tattooing. the combination of ketamine and xylazine did depress the heart rate, respiration rate, and body temperature more than the administration of ketamine alone. t ... | 1978 | 108468 |
| secondary thrombocytopenia following phenobarbital treatments in a rhesus monkey (macaca mulatta). | a rare adverse reaction due to phenobarbital (10 mg/kg/day for 11 days) developed in a rhesus monkey (macaca mulatta). clinical signs and measured hematological parameters correlated closely with descriptions of thrombocytopenia. following cessation of phenobarbital, the monkey recovered within 11 days. five months after initial thrombocytopenia, the monkey was challenged again with phenobarbital (10 mg/kg/day for 11 days). appearance and progression of clinical signs were identical to the initi ... | 1979 | 108473 |
| rhesus monkey (macaca mulatta) model in genetic toxicology mitomycin c clastogenicity in germ cells. | the value of rhesus monkeys (macaca mulatta) as a genetic toxicology model is limited by their scarcity, expense, and impracticality of progeny testing. however, in some special circumstances, e.g., accidental exposure of humans to potential mutagens, rhesus monkeys or other primates may provide a superior animal model to help to cope with a difficult public health situation. using the testis as a target organ we found that when primary spermatocytes were treated in pre-leptotene stage with 1 mg ... | 1979 | 108596 |
| effects of danazol on gonadotropin levels in castrated rhesus monkeys. | danazol is widely used in the management of endometriosis and mammary dysplasia. however, its mechanism of action is still obscure because of the few studies done and the controversial results obtained. antigonadotropic activity has been postulated by some investigators, whereas others have observed no effect on the gonads. in the present study, three castrated female rhesus monkeys received 400 mg of danazol daily, by gavage for 19 days, while 2 controls received 400 mg of lactose daily. blood ... | 1979 | 108640 |
| chronic occlusion of the monkey fallopian tube with silicone polymer. | investigators have previously reported good retention, antifertility efficacy, and oviduct polymer compatibility in rabbit oviducts in studies of both short-term and chronic occlusion with high viscosity silicone polymer. the present study attempts to determine the chronic effects of the silicone polymer installed into the oviducts of 10 rhesus monkeys. unlike former studies with rabbits, the polymer was installed into the fimbrial end of the monkey's oviducts because of the complexity of the ut ... | 1979 | 108641 |
| acquisition and discrimination of appetitively and aversively conditioned heart rate responses in rhesus monkeys. | this report describes the acquisition of a conditional heart rate response to both classical aversive and appetitive conditioning in eight rhesus monkeys (macaca mulatta). the behavioral paradigm consisted of two discrete one minute tones followed by the corresponding unconditional stimuli, i.e., electric shock or purina monkey chow. a third tone followed by neither food nor shock served as a discriminative stimulus (ds). the conditional heart rate responses developed in two phases. the first ph ... | 1978 | 108656 |
| rapid substitution procedure for intravenous drug self-administration studies in rhesus monkeys. | rhesus monkeys were trained to press a lever one hundred times (fr 100) to obtain either a food pellet or an intravenous drug injection. two daily experimental sessions, one in the morning and one in the afternoon, were divided into three 15 minute periods each. in periods 1 and 3 lever pressing behavior was maintained by the delivery of food. period 2 lever pressing was maintained by the intravenous injection of a drug solution. the drug available each day followed a four day sequence of cocain ... | 1979 | 108686 |
| [experimental study on development of physical dependence on alcohol and cross physical dependence liability of diazepam and barbital to alcohol in rhesus monkeys (author's transl)]. | | 1978 | 108696 |
| mutual antagonism of behavioral effects of trh and thiobarbiturate on an operant task in rhesus monkeys. | similar excitatory or depressant response rate dependent effects on monkeys responding on a variable interval reinforcement schedule were observed following intravenous administration of either thyrotropin releasing hormone (trh) or thiobarbiturate. however, these agents were mutally antagonistic when given together even though the response rate altering effects of each agent were in the same direction. these findings establish an additional behavioral effect of exogenously administered trh in p ... | 1979 | 108712 |
| intracranial self-stimulation in orbitofrontal cortex and caudate nucleus of rhesus monkey: effects of apomorphine, pimozide, and spiroperidol. | rhesus monkeys were prepared with stimulating electrodes implanted into the orbitofrontal cortex and head of the caudate nucleus under stereotaxic control. these regions of the brain contain high levels of dopamine, and intracranial self-stimulation was readily elicited from these loci in all animals tested using licking behavior as the operant response. self-stimulation at both sites was significantly attenuated following peripheral injections of the dopamine receptor blocker spiroperidol (0.02 ... | 1979 | 108751 |
| adrenergic and dopaminergic response to chronic chair restraint in the rhesus monkey. | prolonged chair restraint and social isolation in the rhesus monkey led to a reduction in the urinary excretion of hva (4-hydroxy-3-methoxyphenylacetic acid), dopac (3,4-dihydroxyphenylacetic acid), vma methoxy-4-hydroxymandelic acid), and mhpg (3-methoxy-4-hydroxyphenylethylglycol) over a 3 week period. this adaptation to a chronically "stressful" situation corresponds to earlier studies on the rhesus monkey indicating a gradual reduction in the urinary excretion of norepinephrine and epinephri ... | 1979 | 108755 |
| platelet monoamine oxidase activity correlates with social affiliative and agonistic behaviors in normal rhesus monkeys. | after a 4-mo study period, quantitative measures of stable behavioral traits in individual rhesus monkeys correlated significantly with platelet monoamine oxidase (mao) activity. in particular, behavioral items reflecting social activity and social contact, both agonistic and affiliative, were inversely correlated with enzyme activity. time spent alone was positively correlated. since platelet mao activity is generally stable and predominantly controlled by genetic factors, it might serve as a " ... | 1979 | 108757 |
| the in vitro metabolism of progesterone, 4-androstene-3,17-dione, testosterone and 17 beta-hydroxy-5 alpha-androstan-3-one by fetal rhesus monkey testes. | homogenates prepared from fetal rhesus monkey testes were incubated with progesterone, 4-androstene-3,17-dione, testosterone and 17 beta-hydroxy-5 alpha-androstan-3-one. the major progesterone metabolite was 17-hydroxy-4-pregnene-3,20-dione. testosterone also accumulated in the progesterone incubations. 4-androstene-3,17-dione was converted chiefly to testosterone. testosterone was not actively metabolized by the fetal monkey testis. 17 beta-hydroxy-5 alpha-androstan-3-one was actively converted ... | 1979 | 108818 |
| [ultrastructural observations of the retinal pigment epithelial cells following experimental occlusion of the posterior ciliary artery in the rhesus monkey. iv. comparative study between fluorescein angiographic and morphological changes (author's transl)]. | | 1979 | 108926 |
| effect of a low protein diet during pregnancy of the rhesus monkey. ii. physiological adaptation of the infant. | heart rate, respiratory rate, and ability to maintain body temperature were evaluated in six infants born to rhesus monkeys that had been fed a low protein diet throughout pregnancy. all infants were kept in incubations equipped with a "servo" control thermal unit that maintained the infants' skin temperature at 37.0 c (98.6 f). the thermal units were disconnected and the infants were exposed to room temperature (approximately 27 c) for 6-hr periods each day after 24 hr of age in order to determ ... | 1979 | 108992 |
| schwann cell proliferations mimicking medullated retinal nerve fibers. | ophthalmoscopically visible white patches in the optic nerve head and adjacent retina in a rhesus monkey histologically represented peripheral rather than central nervous myelin. this case of schwann cell proliferations appearing as medullated retinal nerve fibers raises questions concerning the relationship of this phenomenon to developmental and acquired lesions of the optic nerve head in man. | 1979 | 109005 |
| [14,15-beta-oxido analog of proscillaridin (hoe 040). a new cardiac glycoside with low arrhythmic activity and greater absorption ratio]. | the 14,15-beta-oxido analogue of proscillaridin a (hoe 040), in a dose 4 times higher showed equally positive-inotropic effect on the isolated guinea pig heart as did proscillaridin a. in the dog in vivo hoe 040 was equally positive-inotropic, as measured by the increase of dp/dt of the left ventricle of the heart, as proscillaridin a. in combination with aconitine, hoe 040 also in 4fold higher dose caused less cardiac fibrillation on the isolated guinea pig heart than did proscillaridin a. the ... | 1979 | 109100 |
| hexachlorobenzene ingestion by female rhesus monkeys: tissue distribution and clinical symptomatology. | | 1979 | 109142 |
| hormonal alterations in female rhesus monkeys fed a diet containing 2, 3,7,8-tetrachlorodibenzo-p-dioxin. | | 1979 | 109152 |
| role of inferior temporal cortex in interhemispheric transfer. | neurons in inferior temporal cortex of the rhesus monkey usually have large receptive fields that extend well across the midline into both visual half-fields. the responsiveness of these neurons to stimuli in the ipsilateral visual half-field depends on the splenium and anterior commissure, the same pathways necessary for interhemispheric transfer of visual habits. since inferior temporal neurons have the same trigger features in both half-fields and are usually binocular, they may be the site o ... | 1979 | 109166 |
| effects of plasma cholesterol lowering agents on hepatobiliary lipid metabolism and cholesterol turnover in the rhesus monkey. | the effects of clofibrate, cholestyramine, and neomycin on hepatobiliary lipid metabolism were studied in adult rhesus monkeys in metabolic steady state with intact but exteriorized enterohepatic circulations. clofibrate (30 mg/kg, id) had no effect on lipid secretion while cholestyramine (150 mg/kg, id) decreased biliary cholesterol secretion rate from 0.19 +/- 0.03 to 0.13 +/- 0.02 mmol/24 h, p less than 0.05. neomycin (30 mg/kg, id) decreased bile flow from 216 +/- 10 to 191 +/- 7ml/24 h, p l ... | 1979 | 109175 |
| comparative metabolism of hexachlorobenzene and pentachloronitrobenzene in plants, rats, and rhesus monkeys. | | 1978 | 109270 |
| thyroxine-binding globulin metabolism in rhesus monkeys: effects of hyper- and hypothyroidism. | | 1979 | 109273 |
| estrogen-induced gonadotropin surges in female rhesus monkeys after pituitary stalk section. | in order to investigate the primary site of action of estradiol, whether pituitary or hypothalamic, gonadotropin responses to estrogen were studied in female rhesus monkeys before and immediately after pituitary stalk section. the estrogen challenge, consisting of either an injection of estradio benzoate (400 microgram) or an implant of three silastic capsules containing 17 beta-estradiol, was initiated on days 2--5 of the menstrual cycle. the estrogen was given not later than 8 h after stalk se ... | 1979 | 109276 |
| progesterone and 5 alpha-pregnane-3,20-dione in serum of peripartum rhesus monkeys. | | 1979 | 109278 |
| evidence that prolactin stimulates alpha-lactalbumin production in mannary tissues from premenarcheal rhesus monkeys. | prl was found to stimulate marked increases in alpha-lactalbumin production in six of eight specimens of mammary tissue from premenarcheal rhesus monkeys, and a lesser increase was seen in a seventh. even without added prl, low concentrations of this milk protein (mean total alpha-lactalbumin production, 1.9 ng/dish) were released into the organ culture medium bathing these relatively immature tissues; most of the epithelial elements were ductal. under similar conditions, significantly higher co ... | 1979 | 109282 |
| effects of 17 beta-estradiol on serum protlactin levels and on prolactin responses to thyrotropin-releasing hormone in female rhesus monkeys. | | 1979 | 109283 |
| between-ovary interaction in the regulation of follicle growth, corpus luteum function, and gonadotropin secretion in the primate ovarian cycle. iii. temporal and spatial dissociation of folliculogenesis and negative feedback regulation of tonic gonadotropin release after luteectomy in rhesus monkeys. | this study was designed to examine effects of previous ovarian status on subsequent follicle growth and the role of between-ovary communication in the regulation of folliculogenesis and gonadotropin secretion during the primate ovarian cycle. responses to luteectomy were compared in two groups of rhesus monkeys. in the first, follicle growth and corpus luteum function had been constrained chronically to a single ovary by hemiovariectomy performed 66--258 days earlier; the second group was compos ... | 1979 | 109289 |
| ascaris-induced respiratory responses in the conscious rhesus monkey. | reproducible immediate-type respiratory responses were evoked in conscious monkeys, sensitive to inhaled ascaris suum, for periods up to 18 months. these responses were characterized by decreases in tidal volume and increases in breathing rate that persisted for about 40 min. maximum changes were seen 3--5 min after exposure to the aerosolized antigen and were often accompanied by coughing and increased movement of the animals within the plethysmograph used for monitoring their ventilatory chang ... | 1979 | 109398 |
| immunoglobulin e, mast cells, and eosinophils in the skin of rhesus monkeys immunized with x-irradiated cercariae of schistosoma japonicum. | immunoglobulin e (ige), mast cells, and eosinophils in the skin of rhesus monkeys immunized with highly x-irradiated cercariae of schistosoma japonicum were studied. ige was stained by the unlabeled antibody enzyme method and was found on mast cells. before challenge, mast cells were found only in the dermis. immediately after the challenge, mast cells were found in both the dermis and epidermis and many of them were degranulated. soon after, margination and emigration of granulocytes, predomina ... | 1979 | 109404 |
| umbilical vein as ureteral replacement. | in 13 dogs the middle one-third of the ureter and in four dogs the entire ureter was replaced by fresh rhesus monkey or human umbilical cord vein. the overall success rate was 60 per cent (10/17); one dog revealed an excellent intravenous pyelogram; the typical roentgenographic appearance of the kidney was a slight hydronephrosis. animals surviving for more than 1 year were nephrectomized on the contralateral side. one dog is still alive at 36 months. histologically, the typical structures of th ... | 1979 | 109414 |
| primate model of sprue-like syndrome. | an experimental model resembling so-called tropical sprue has been produced in young, growing rhesus monkeys kept on a protein-deficient diet. at a 2% level of protein intake, the animals became frankly diseased after two months, but at a 5% protein intake the symptoms appeared after five months. the animals lost weight, their skin became brittle, the fur lost luster, and facial edema appeared. the hematocrit, and serum folate, protein and albumin were significantly decreased, and intestinal abs ... | 1979 | 109418 |
| sodium taurocholate modifies the bile acid-independent fraction of canalicular bile flow in the rhesus monkey. | bile acid-independent secretion and the choleretic response to taurocholate were determined in rhesus monkeys fitted with indwelling silastic cannulas in the common bile ducts. bile acids were infused intravenously in random order at 3.5, 7.0, or 10.5 mumol/min for 1.5 h each. when data were analyzed with a single regression line, bile flow increased in proportion to the level of bile acid secretion, although the y-intercepts (the conventional measurement of bile acid-independent secretion) vari ... | 1979 | 109471 |
| ionophore and arachidonic acid stimulation of airway responses in rhesus monkeys. | aerosolized doses of the ionophore, a23187, and arachidonic acid individually resulted in no airway response in rhesus monkeys. when these two agents were given simultaneously, by aerosol, an airway response occurred. the pulmonary function abnormalities that occurred qualitatively simulated those of an antigen-induced airway response. this is the first demonstration in our laboratory of two agents which singly will not produce a response but which are reactive when delivered in combination. oth ... | 1979 | 109472 |
| the distribution of retino-collicular axon terminals in rhesus monkey. | the retino-collicular projections in rhesus monkeys were studied using standard autoradiographic and degeneration techniques. a computer based technique was developed which provided a flattened visual display of the retinal projection onto the entire superior colliculus, quantified the area covered by such projections for different segments of the colliculus and showed how this morphological pattern varied with depth beneath the collicular surface. in the anterolateral third of the colliculus (i ... | 1979 | 109475 |
| rhesus monkey b lymphocyte surface immunoglobulin: analysis with a fluorescence-activated cell sorter. | | 1979 | 109515 |
| in vitro stimulation of natural killer (nk) cells by soluble factor(s) generated in antigen-stimulated rhesus monkey peripheral blood lymphocyte cultures. | peripheral blood lymphocytes from rhesus monkeys (macaca mulatta) sensitized to keyhole limpet hemocyanin (klh), when stimulated in vitro with klh, developed natural killer (nk) cell activity that was assayed with rous sarcoma virus-transformed marmoset fibroblasts as targets in a 4-hr 51cr-release assay. the supernatant fluids from 24- to 25-hr klh-activated cultures were capable of stimulating nk development in nonsensitive lymphocyte cultures. the effector cells were neither macrophages nor b ... | 1979 | 109523 |
| protective and toxic effects of a nuclease-resistant derivative of polyriboinosinic-polyribocytidylic acid on venezuelan equine encephalomyelitis virus in rhesus monkeys. | polyriboinosinic-polyribocytidylic acid, stabilized with poly-l-lysine and carboxymethylcellulose (poly iclc), favorably alters the pathogenesis of venezuelan equine encephalomyelitis virus infection in rhesus monkeys by decreasing the number of infected monkey that become detectably viremic and by delaying the onset of viremia in the remaining monkeys. poly iclc is known to induce high circulating levels of interferon in primates, and the interferon system is assumed to be the mechanism by whic ... | 1979 | 109544 |
| induction of congenital hydrocephalus with mumps virus in rhesus monkeys. | rhesus monkey fetuses were inoculated intracerebrally with wild-type mumps virus near the beginning of the last third of the gestation period. within three days after inoculation, mumps virus was isolated from many fetal tissues. thirteen animals receiving virus were delivered at term. five of these showed slight to severe hydrocephalus. hydrocephalus was most prominent in the posterior horns of the lateral ventricles, but other lesions occurred at various levels of the ventricular system. virus ... | 1979 | 109547 |
| acute occlusion of the posterior spinal vein. experimental study in monkeys. | the posterior spinal vein was occluded with silicone in seven rhesus monkeys, and locally resected in one. there were no neurological findings associated with acute venous obstruction of the cord. follow-up arteriography revealed diversion of venous outflow into the anterior spinal venous system. histology revealed gliosis associated with demyelinization confined to the posterior columns. | 1979 | 109580 |
| animal infectivity of encephalitozoon cuniculi. | rabbits, mice, rats and rhesus monkeys were infected experimentally with a rabbit isolate of the mammalian microsporidan encephalitozoon cuniculi. the lesions produced were typical of those occurring in spontaneous encephalitozoonosis in rabbits, mice, and rats, respectively. viable e. cuniculi were recovered from tissues of injected animals with and without lesions. titration of rabbit, mouse, and hamster isolates of e. cuniculi in mice and in rabbit choroid plexus cell cultures showed that the ... | 1979 | 109602 |
| experimental babesia microti infections in non-splenectomized macaca mulatta. | eight non-splenectomized macaca mulatta were inoculated intravenously with strains of babesia microti that originally were isolated from 2 human cases of babesiosis and then were maintained in hamsters in the laboratory. patent infections developed in 7 animals with peak parasitemias of 496 to 3,906 organisms/mm3 blood. prepatent periods ranged from 15 to 46 days. parasitemia persisted for at least 90 days in all animals and in one, organisms were still present 559 days after inoculation. | 1979 | 109604 |
| [alcohol-induced hypophysectomy--its effect on tooth pulp evoked potentials in the rhesus monkey (author's transl)]. | | 1979 | 109646 |
| aspects of the control of feeding: application of quantitation in psychobiology. | in rhesus monkeys equipped with indwelling gastric cannulae and studied in the unanesthetized state, it is possible to demonstrate that their feeding is a precisely regulated behavior functioning to maintain caloric intake quite constant. the infusion of nutrients into the stomach through the cannula results in a reduction in their feeding by an amount that is equivalent to the caloric value of the infusion. a similar precise recovery from caloric deficits by overeating can also be demonstrated. ... | 1979 | 109695 |
| drinking of ethanol by adult and infant rhesus monkeys (macaca mulatta). | levels of voluntary consumption of ethanol were obtained which were sufficient for use in developing a nonhuman primate model of heavy drinking. | 1979 | 109702 |
| adrenocortical function in experimental protein malnutrition. | adrenocorticoid activity was investigated in experimentally induced protein malnutrition in rhesus monkeys. control studies were carried out in the same animals before inducing protein malnutrition. plasma cortisol levels were elevated in the protein malnourished state. there was a total abolition of the diurnal rhythm of cortisol secretion. fasting hypoglycemia was also observed in the protein malnourished state. it is concluded that increased adrenocorticoid activity and sustained steroidogene ... | 1979 | 109732 |
| rapid evolution of animal mitochondrial dna. | mitochondrial dna was purified from four species of higher primates (guinea baboon, rhesus macaque, guenon, and human) and digested with 11 restriction endonucleases. a cleavage map was constructed for the mitochondrial dna of each species. comparison of the maps, aligned with respect to the origin and direction of dna replication, revealed that the species differ from one another at most of the cleavage sites. the degree of divergence in nucleotide sequence at these sites was calculated from th ... | 1979 | 109836 |
| interactions of acetylmethadol or methadone with other drugs in rhesus monkeys. | behavioral effects and blood or plasma levels of d-amphetamine, ethanol, cocaine, and diazepam were examined in rhesus monkeys treated chronically with alpha-l-acetylmethadol (laam), methadone, or vehicle. chronic treatment with the opiates failed to alter blood or plasma levels and behavioral effects of d-amphetamine or ethanol. laam-maintained monkeys were somewhat less sensitive to rate-decreasing effects of cocaine on schedule-controlled responding, but cocaine plasma levels and half-lives g ... | 1979 | 109865 |
| effects of the neuropeptide dg-avp on morphine and food self-administration by dependent rhesus monkey. | pretreatment with the neuropeptide dg-avp (desglycrinamide9-arginine8-vasopressin) at two dose levels (25 and 125 mcg/kg) did not reduce intravenous morphine self-administration (0.25 mg/kg/inj) by morpine dependent monkeys, in comparison to pretreatment with saline or dg-avp vehicle placebo. food self-administration was also unaffected by dg-avp pretreatment in comparison to control conditions. these data do not confirm previous reports of a dose-dependent suppression of heroin self-administrat ... | 1979 | 109866 |
| plasma and tissue levels of furosemide in dogs and monkeys following single and multiple oral doses. | 35s-furosemide was administered to beagle dogs and rhesus monkeys as an oral solution on a single and a 20 repeated 5 mg/kg/day dosing regimen. in both species, furosemide is rapidly but incompletely absorbed with peak plasma levels being achieved within one hour after dosing. the plasma level versus time profiles do not appear to be significantly altered as a result of the repetitive dosing regimen employed, although the profiles themselves are quite different for the two species studied. follo ... | 1979 | 109903 |
| inhibitory, gabaergic nerve terminals decrease at sites of focal epilepsy. | using an immunocytochemical method for the localization of the gamma-aminobutyric acid (gaba) synthesizing enzyme, glutamic acid decarboxylase (gad), we have observed gabaergic nerve terminals distributed throughout all layers of normal monkey sensorimotor cortex. these terminals displayed ultrastructural characteristics that suggested that they arose from aspinous and sparsely spinous stellate neurons. in monkeys (macaca mulatta and m. fascicularis) made epileptic by cortical application of alu ... | 1979 | 109922 |
| orientation anisotropy of visual stimuli in rhesus monkey: a behavior study. | the contrast sensitivity of the rhesus monkey was tested, according to a modified reaction-time paradigm, for sine-wave grating targets at different orientations. the monkey possesses an oblique effect slightly larger than that of humans. a reaction time analysis showed the oblique effect to be a suprathreshold as well as a threshold phenomenon. the presence of this effect further strengthens the use of the monkey as a model for the human visual system. | 1979 | 109923 |
| subicular input from temporal cortex in the rhesus monkey. | the subicular cortices of the primate hippocampal formation form a physical and connectional link between the cortex of the temporal lobe and the hippocampus. their direct connections with all classes of cortex in the temporal lobe except primary sensory cortex underscore the pivotal role of these areas in the potential interplay between the hippocampal formation and the association cortices. | 1979 | 109926 |
| comparative distribution and embryotoxicity of methotrexate in pregnant rats and rhesus monkeys. | | 1979 | 109943 |
| spermatic granuloma of vas deferens after vasectomy in rhesus monkeys and men: light and electron microscopic study. | spermatic granuloma of the vas deferens is a common complication of vasectomy which has received scant morphologic study. this study investigated the light and electron microscopic structure of such granulomas detected in rhesus monkeys (macaca mulatta) and man after various modes of vasectomy and postoperative periods. unilateral experimental vasectomy in monkeys was performed by either silk ligation or clasp occlusion; in 4 of 13 ligated animals and 5 of 5 clasp vasectomized animals granulomas ... | 1979 | 109982 |
| the importance of side-chain hydroxylated metabolites of delta6-tetrahydrocannabinol in rhesus monkey. | | 1979 | 110031 |
| the continuous cultivation of plasmodium fragile by the method of trager-jensen. | using the trager-jensen method, a second malaria species, plasmodium fragile, a simian counterpart to the human malaria p. falciparum, has been cultivated successfully. the average growth rate every 3--4 days was 5-fold and the average number of merozoites observed was 14. to date, only rhesus monkey red blood cells (rbc) would support the long-term cultivation of this parasite. short-term observations indicate that rbc from the squirrel monkey (saimiri sciureus) may support growth but human rbc ... | 1979 | 110165 |
| alcohol-induced pituitary adenolysis: how does it control intractable cancer pain?--an experimental study using tooth pulp-evoked potentials in rhesus monkeys. | | 1979 | 110174 |
| comparative toxicity of three halogenated dibenzofurans in guinea pigs, mice, and rhesus monkeys. | | 1979 | 110190 |
| adequate anticoagulation during cardiopulmonary bypass determined by activated clotting time and the appearance of fibrin monomer. | the adequacy of anticoagulation during 2 hours of cardiopulmonary bypass at 30 degrees c in 9 rhesus monkeys was determined by measuring the whole-blood activated clotting time (act) and by noting the appearance of thrombin-altered fibrin (fibrin monomer) and the relative consumption of clotting factors. factor v and viii, the heparin cofactor, antithrombin iii, prothrombin time, partial thromboplastin time, act, platelets, hematocrit, fibrinogen, and fibrin monomer were determined prior to hepa ... | 1978 | 110273 |
| the effect of ligating the ovarian and uterine arteries on ovarian function in cyclic rhesus monkeys. | | 1979 | 110367 |