| a study of klebsiella infections in owl monkeys (aotus trivirgatus). | | 1970 | 4991977 |
| experimental retinal detachment in the owl monkey. vii. photoreceptor protein renewal in normal and detached retina. | | 1971 | 4993689 |
| applanation and schiotz tonometer standardizations for the owl monkey eye with a new technique for measuring episcleral venous pressure. | | 1971 | 4994059 |
| malarial s-antigens from man and owl monkey infected with plasmodium falciparum. | | 1970 | 4994295 |
| renal carcinoma in an owl monkey (aotus trivirgatus). | | 1970 | 4994576 |
| comparison of schistosoma haematobium, s. mansoni, and s. japonicum infections in the owl monkey, aotus trivirgatus. | | 1971 | 4996977 |
| plasmodium vivax infections in aotus trivirgatus. | | 1971 | 4998615 |
| a representation of the visual field in the caudal third of the middle tempral gyrus of the owl monkey (aotus trivirgatus). | | 1971 | 4998922 |
| experimental retinal detachment in the owl monkey. 8. photoreceptor protein renewal in early retinal reattachment. | | 1971 | 4998987 |
| mycobacterium abscessus infection in an owl monkey (aotus trivirgatua). | | 1970 | 4999881 |
| representation of the visual field in striate and adjoining cortex of the owl monkey (aotus trivirgatus). | | 1971 | 5002564 |
| dermatophilosis in owl monkeys. | | 1971 | 5002650 |
| acute lymphocytic leukemia in owl monkeys inoculated with herpesvirus saimiri. | our study demonstrates for the first time that herpesvirus saimiri can induce acute lymphocytic leukemia in owl monkeys (aotus trivirgatus) and that malignant lymphoma can be induced in this species of nonhuman primates by the inoculation of the virus by various routes (intravenous, sub-cutaneous, and intradermal). | 1971 | 5544872 |
| experimental occlusion of retinal and ciliary vessels in owl monkeys. i. technique and clinical observations of selective embolism of the central retinal artery system. | | 1967 | 6060551 |
| a single major immediate-early virus gene product is synthesized in cells productively infected with herpesvirus saimiri. | a major virus-specific immediate-early (ie) polypeptide with an apparent mol. wt. of 52 000 (52k) was synthesized immediately after the removal of a cycloheximide block applied to owl monkey kidney cell cultures at the time of infection with high multiplicities of herpesvirus saimiri (hvs). the ie 52k polypeptide was phosphorylated and accumulated rapidly and efficiently in the nucleus of infected cells. monoclonal antibodies to ie 52k and to a major non-structural delayed-early (de) dna-binding ... | 1984 | 6086813 |
| human cytomegalovirus dna sequences with homologies to the cellular genome. | dna from a cosmid-cloned gene library of human cytomegalovirus (hcmv) strain ad169 was found to share sequence homologies with cellular dna of various origins. viral dna fragments subcloned in plasmid vectors enabled localization of the homologous sequences to five regions of the hcmv genome. four of these regions were found in the long unique (ul) segment of the viral genome (ecori fragments r, i and b, and hindiii fragment s); one region with virus--cell homology was located in the terminal in ... | 1984 | 6086821 |
| transformation of owl monkey t cells in vitro with herpesvirus saimiri. | owl monkey peripheral blood mononuclear cells were treated with phytohemagglutinin and expanded in interleukin 2 (il-2)-containing medium. the cells were then exposed to herpesvirus saimiri (hvs strain s295c)-infected owl monkey kidney monolayer cells. four to 6 weeks later, the lymphocytes showed increased clumping and cell growth and the ability to grow in the absence of il-2. control lymphocyte cultures not exposed to hvs eventually died out at approximately 6-8 weeks, even in the presence of ... | 1984 | 6087333 |
| interaction of n-methyl-n'-nitro-n-nitrosoguanidine (mnng) with owl monkey kidney cells in enhancing the yields of herpesvirus saimiri (hvs) and its antigens. | pre- and posttreatment with n-methyl-n'-nitro-nitrosoguanidine (mnng) of owl monkey kidney (omk) cells infected with herpesvirus saimiri (hvs) resulted in one to three logs higher yields of virus, depending upon the dose of mnng. a higher percentage of cells also showed hvs early antigen (ea) and late antigen (la) by immunofluorescence when omk cells infected with hvs were fed with medium containing mnng. the high yields of hvs were also observed by electron microscopy. mnng did not induce hvs-e ... | 1984 | 6087360 |
| jc virus-induced owl monkey glioblastoma cells in culture: biological properties associated with the viral early gene product. | jcv induces glioblastomas in owl monkeys 18-24 months or longer following intracranial inoculation (w. london, s. houff, d. madden, d. fuccillo, m. gravell, w. wallen, a. palmer, j. sever, b. padgett, d. walker, g. zu rhein, and t. ohashi, 1978, science 201, 1246-1248). cells from one brain tumor, owl monkey 26, were successfully established in culture and analyzed for phenotypic characteristics generally associated with persistence and expression of the papovavirus early region of its genome. o ... | 1984 | 6087549 |
| [infection of new world primates with junín virus. iv. aotus trivirgatus]. | owl monkeys (aotus trivirgatus) were inoculated with xj, a pathogenic strain of junin virus, seeking new animal models for argentine hemorrhagic fever. nine monkeys were inoculated intramuscularly with 30 or 300,000 tcid50 of junin virus. hematological and virological studies showed no alteration in blood elements such as red cell, reticular cell and platelets, up to 28 days after inoculation. hemoglobin and hematocrit determinations also remained constant. however, significant neutropenia was s ... | 1983 | 6101070 |
| the response properties of cells in the middle temporal area (area mt) of owl monkey visual cortex. | recordings from 178 single cells in the middle temporal area (area mt) of owl monkey showed that most cells there are orientation- and direction-selective. they also revealed that a powerful range of binocular interactions occur in area mt, with 20% of the cells being responsive to binocular stimulation only, 5% to monocular stimulation only and about 50% of all cells showing some degree of interocular interaction. | 1980 | 6102766 |
| susceptibility of peruvian aotus monkeys to infection with different species of plasmodium. | splenectomized aotus trivirgatus monkeys of peruvian origin were tested for their susceptibility to infection with different species of plasmodium. strains of p. vivax from vietnam and el salvador produced infections in eight animals with maximum parasite densities ranging from 2,000-180,000 per mm3. a strain of p. falciparum from cambodia produced maximum parasitemias in five animals ranging from 8-25% of the red blood cells infected. although two monkeys inoculated with p. fragile had maximum ... | 1981 | 6111233 |
| hepatitis a virus among captive panamanian owl monkeys. | | 1981 | 6118799 |
| dark switch in the entrainment of circadian activity rhythms in night monkeys. aotus trivirgatus humboldt. | 1. the locomotor activity of the night monkey (aotus trivirgatus) has been shown to be related to light intensity by an optimum function; here entrainment by ld cycles is examined to see whether the mechanism of synchronization of circadian periodicity in aotus is based on this function. 2. eleven night monkeys of various ages, previously in either a free-running phase or in ld 12:12 (10(2):10(-1) lux), were recorded in ld 12:12 with the optimal intensity (10(-1) lux) in the light part of the cy ... | 1983 | 6131772 |
| a monoclonal antibody recognizing human thy-1: distribution on human and non-human primate haematopoietic cells. | a monoclonal antibody designated 'antibody 390' (ab 390) with anti-human thy-1 reactivity was prepared by the hybridoma technique from the splenocytes of balb/c mice immunized with human fetal brain. this antibody was shown to have anti-human thy-1 reactivity because (1) it precipitated a molecule with a molecular weight of about 24,000 daltons, (2) it had a pattern of reactivity similar to that of previously described anti-human thy-1 antibodies and (3) purified human thy-1 antigen specifically ... | 1984 | 6151574 |
| failure of unilateral carotid artery ligation to affect pressure-induced interruption of rapid axonal transport in primate optic nerves. | previous experiments showed that optic nerve axonal transport can be blocked at the level of the lamina cribrosa by elevated intraocular pressure. in an effort to discover if this blockage might be secondary to pressure-induced ischemia, we studied the effect of unilateral common carotid artery ligation upont the pressure-induced interruption of axonal transport. in 13 owl monkeys (aotus trivirgatus), the right common carotid artery was ligated within the anterior cervical triangle. three days l ... | 1980 | 6153174 |
| immunological relationships of omc-1, an endogenous virus of owl monkeys, with mammalian and avian type c viruses. | the relationships between omc-1, an endogenous oncovirus of owl monkey, and representatives of the three oncoviral genera have been investigated by radioimmunological techniques. the major structural protein of omc-1 was shown to share antigenic determinants with the corresponding proteins of certain type c viruses of rodent, feline, and cervine origin. it was not possible to demonstrate antigenic cross-reactivity between omc-1 and endogenous type c viruses of baboons. these findings argue that ... | 1980 | 6154152 |
| urinary excretion of catecholamines in the night monkey (aotus trivirgatus) (primates, cebidae). | a seasonal variation in the urinary catecholamines output has been demonstrated in two simians kept under constant ambient conditions : the nocturnal aotus and the diurnal saïmiri sciureus. in aotus, catecholamines output (na + a), in spring, is higher than in other primates including man and even more so in winter. cold exposure increases the na + a excretion in aotus as it does in squirrel monkey and rat but the a output is particularly prominent in saïmiri. fasting does not alter significantl ... | 1981 | 6174092 |
| erythrocyte protoporphyrin levels in aotus trivirgatus. | high levels of the heme precursor, protoporphyrin, were found in a sample of 36 aotus trivirgatus. the owl monkeys were of five different karyotypes and from three separate colonies. in many animals, a significant proportion of the protoporphyrin was not bound to zinc, as is normal, but existed as the free base protoporphyrin ix. the protoporphyrinemia may be related to major pathologies of captive aotus. | 1981 | 6177858 |
| specifically unmethylated cytidylic-guanylate sites in herpesvirus saimiri dna in tumor cells. | the restriction endonucleases mspi (ccgg), hpaii (ccgg), fnudii (cgcg), and haeiii (ggcc) were used to study the methylation of herpesvirus saimiri dna in tumor cells taken directly from tumor-bearing animals. no evidence was found for methylation of the 5' terminal c in the sequence ccgg or of the internal c in the sequence ggcc, but extensive methylation of cg was detected. fifteen hpaii sites and 17 fnudii sites were detected in the unique dna region of the h. saimiri strain used. twenty-eigh ... | 1982 | 6180177 |
| surface markers of primate b and t lymphoid cell lines identified by antibodies to human and simian lymphocyte antigens. | simian b and t lymphoid cell lines were shown to maintain surface markers found on mature lymphocytes in vivo. the t lymphoid cell lines expressed ia-like antigens on their surfaces, further suggesting that they represent mature, activated t cells. these ia antigens show a structural similarity to ia on human cells although some diversity exists. the ia antigen expressed on t lymphoid cell lines was shown to be very similar to those on b lymphoid cell lines. owl monkey and marmoset t lymphoid ce ... | 1982 | 6181170 |
| pressure-induced fast axonal transport abnormalities and the anatomy at the lamina cribrosa in primate eyes. | in ten owl monkey eyes (aotus trivirgatus) the location of pressure-induced (perfusion pressure 35 mmhg) axonal transport abnormalities was determined by the examination of serial step cross-section tissue radio autographs from the optic nerve head. the degree of the local transport interruption did not correlate with the fiber bundle cross-section area, the shape of the laminar pores or the density of the inter-bundle septa in that region. | 1983 | 6187704 |
| effects of monocular deprivation on geniculocortical pathways in the owl monkey, aotus trivirgatus. | as has been shown for a number of other mammals, monocular eyelid suture in the newborn owl monkey, a new world primate, is followed by a failure of neurons in the deprived layers of the lateral geniculate nucleus to reach normal size in the adult animal. this failure appears to be almost completely confined to relay cells, identified by horseradish peroxidase (hrp) injections into cortex, rather than interneurons. similar proportions of neurons in both the deprived and non-deprived layers are l ... | 1980 | 6189025 |
| radial keratotomy and corneal permeability in owl monkey. | radial keratotomy was performed on owl monkey corneas using 8 incisions with sparing of a 3.5mm central pupillary area. cornea endothelial membrane permeabilities were determined at 2 days, and 4 weeks, following the procedure using simultaneous flux determinations of 3h-labeled inulin and 14c-labelled dextran. inulin permeability was increased 27% two days following the procedure, and had returned to levels comparable to the unoperated eye 4 weeks following the procedure. dextran permeability w ... | 1983 | 6192675 |
| recent evolution of dna sequence homology in the pericentromeric regions of human acrocentric chromosomes. | a search for genes located on human chromosome 21 resulted in the isolation of a hela cdna clone, punc724, which hybridized to 3.7 and 2.5 kilobase (kb) ecori fragments on each of the human acrocentric chromosomes. in situ hybridization further localized punc724 to the pericentromeric region of the human acrocentrics. two other ecori fragments that hybridized to punc724 were assigned to the long arms of chromosomes 1 and 18. the punc724 sequence does not appear to be related to ribosomal or sate ... | 1984 | 6205826 |
| antiviral cell-mediated immune responses and effect of chromosome polymorphism in herpesvirus saimiri-infected monkeys. | herpesvirus saimiri is a horizontally transmitted virus of squirrel monkeys (saimiri sciureus) which, when inoculated into owl monkeys (aotus trivirgatus), induces fatal malignant lymphoma in 75 to 80% of the animals. previous immunological and virological studies have not indicated why 20 to 25% of inoculated owl monkeys develop a chronic, disease-free h. saimiri infection. in the present study, we examined two parameters to explain why certain owl monkeys are resistant to h. saimiri-induced di ... | 1980 | 6247277 |
| proteins of herpesvirus saimiri: identification of two virus polypeptides released into the culture medium of productively infected cells. | two virus-induced polypeptides are preferentially released into the culture medium of owl monkey kidney cells productively infected with herpesvirus saimiri (hvs). these polypeptides have apparent mol. wt. of 160 x 10(3) and 28 x 10(3) and are the major virus-induced polypeptides in a membrane fraction from infected cells. both these excreted polypeptides co-migrate with virus structural proteins and are selectively released from enveloped virus particles by treatment with nonidet-p40. | 1980 | 6262446 |
| infection of multiple t-cell subsets and changes in lymphocyte functions associated with herpesvirus saimiri infection of owl monkeys. | we examined the association of herpesvirus saimiri with lymphocyte subsets and the functional integrity and distribution of these populations in owl monkeys with chronic, disease-free infections, in uninoculated, control animals, and in one monkey with h. saimiri-induced lymphoma. the lymphocyte subpopulations examined included total t cells, t cells with receptors for the fc portion of immunoglobulin g (the tgamma cells), t cells lacking this receptor (the tgamma(-) population), and non-t cells ... | 1981 | 6265360 |
| expression of epstein-barr viral early antigen in monolayer tissue cultures after transfection with viral dna and dna fragments. | antigens associated with the epstein-barr virus (ebv) replicative cycle were found in the nucleus and cytoplasm of human placental, vero, bsc-1, and owl monkey kidney cells transfected with ebv dna prepared from several different strains of virus. the number of antigen-positive nuclei increased when transfection was followed by cell fusion induced by inactivated sendai virus. about 1,200 antigen-positive foci were induced per micrograms of ebv dna. on the basis of their reactivity with various w ... | 1981 | 6275121 |
| comparison of thymidine kinase activities indiced in cells productively infected with herpesvirus saimiri and herpes simplex virus. | the replication of unselected strains of herpesvirus saimiri (hvs) was sensitive to bromodeoxyuridine and bromovinyldeoxyuridine (bvdu) but insensitive to acycloguanosine (acg), in contrast to the growth of herpes simplex virus (hsv) which was sensitive to all three analogues. mutants of hvs resistant to bromodeoxyuridine and bvdu could be selected by growth in the presence of these inhibitors. productive infections of owl monkey kidney or vero cell cultures by unselected strains of hvs resulted ... | 1982 | 6278057 |
| herpesvirus saimiri strain variability. | herpesvirus saimiri was isolated from 22 squirrel monkeys by cocultivation of peripheral lymphocytes with permissive owl monkey kidney monolayer cells. comparison of virion dna fragments produced from restriction endonuclease digestion was used as a sensitive measure of strain variability. although all isolates contained similarities and common features, 19 of the 22 were readily distinguished. three of the isolates, however, were indistinguishable and possibly were related epidemiologically. di ... | 1982 | 6287011 |
| transmission of hepatitis a virus among recently captured panamanian owl monkeys. | the presence of antibody to hepatitis a virus (anti-hav) in 60% of procured owl monkeys (aotus trivirgatus) held within the united states prompted a study of recently captured a trivirgatus in panama. only 2 of 145 newly captured monkeys, but all of 35 a trivirgatus held within a colony for over 100 days, were found to have anti-hav. of 41 sero-negative, newly captured monkeys followed prospectively, 25 became infected with hepatitis a virus (hav) as evidenced by seroconversion or demonstration ... | 1982 | 6290600 |
| herpesvirus saimiri-induced proteins in lytically infected cells. i. time-ordered synthesis. | the addition of tpa (phorbol-12-myristate-13-acetate) to cultures during the lytic infection with herpesvirus saimiri led to an enhanced and accelerated production of polypeptides induced by h. saimiri and to a rapid shut-down of host cell protein synthesis and allowed a detailed analysis of the protein patterns. analysis of sequential protein synthesis in owl monkey kidney cells lytically infected with h. saimiri 11 permitted the identification of 31 virus-induced polypeptides. the use of the a ... | 1983 | 6296304 |
| natural killer cells in relation to herpesvirus saimiri-induced disease course and manifestations in owl monkeys. | infection of owl monkeys with herpesvirus saimiri (hvs) results in disease courses ranging from chronic infections to fatal cancers. malignant disease manifestations include the appearance of transformed t-cells, suppressor t-cells, and virus-carrying cells in the peripheral circulation. the reasons for the variability in disease course remain unknown. this study examined natural killer (nk) functions in relation to disease manifestations following hvs infection. the results from lymphocyte frac ... | 1983 | 6296516 |
| effectiveness of allopurinol against leishmania braziliensis panamensis in aotus trivirgatus. | orally administered allopurinol at 50 mg/kg for 21 days showed pronounced antileishmanial activity against experimentally induced lesions of leishmania braziliensis panamensis on the nose of panamanian aotus trivirgatus monkeys, with complete healing in 4 of 5, although parasitologic cure was achieved in only 2 of 5. the same total daily dose of drug, given in a divided dose twice daily, resulted in complete healing in all 5, and parasitologic cure in 4 of 5 animals. standard treatment controls ... | 1983 | 6297325 |
| failure of herpesvirus saimiri to enhance atherogenesis in owl monkeys (aotus trivirgatus). | a retrospective study was performed to evaluate the potential of a mammalian oncogenic virus, herpesvirus saimiri, to cause atherosclerosis in owl monkeys (aotus trivirgatus). this was undertaken since an avian oncogenic herpesvirus, marek's disease virus, does so in chickens. data from earlier studies were reviewed and 3 groups of animals were selected. these included 23 animals infected with herpesvirus that died an average of 156 days later with malignant lymphoma; 11 infected an average of 2 ... | 1983 | 6301514 |
| new world primates as a model of viral-induced astrocytomas. | owl and squirrel monkeys are susceptible to the oncogenic effects of jcv. these species of new world monkeys can be safely inoculated intracerebrally. care must be taken with owl monkeys since they have an inherited clotting abnormality. incubation times for the development of tumors range from 14 to 30 months. anorexia was the first clinical sign of tumor development. the clinical course is rapid with death within two to three days. this model provides a means for studying diagnostic, virologic ... | 1983 | 6304759 |
| viral-induced astrocytomas in squirrel monkeys. | saimiri sciureus, the squirrel monkey, is susceptible to the oncogenic effects of jcv following intracerebral inoculation. as in owl monkeys, tumor development follows an incubation time of 14 to 30 months. four of six virus-inoculated monkeys developed cerebral tumors, three of which were astrocytomas grade 4 and the remaining tumor was a poorly differentiated astrocytoma. all tumors showed high cellularity, mitotic figures, and cellular pleomorphism. in the astrocytoma grade 4, neovascularizat ... | 1983 | 6304760 |
| glial and divergent cells in primate central nervous system tumors induced by jc virus isolated from human progressive multifocal leukoencephalopathy (pml). | immunofluorescent stains for fibronectin (fn) and glial fibrillary acidic protein (gfap) were used in conjunction with routine histologic stains to study tumors induced in squirrel and owl monkeys by jc virus from progressive multifocal leukoencephalopathy (pml). three varieties of glioma were identified. the first and most common variety was a neoplasm similar to grade 4 astrocytoma in humans. the second had thin, normal-appearing fn-positive vessel walls and a vastly expanded neuroectodermal p ... | 1983 | 6304761 |
| antibody responses to jc virus-associated antigens by tumor-bearing owl monkeys. | antibody responses to jcv viral and t antigens were determined in owl monkeys following infection with jcv. antibody to jcv virion antigen was present in all inoculated monkeys, arising within one months. these antibodies gradually diminished in all nontumor-bearing monkeys and in 10/13 tumor-bearing monkeys over the ensuing 12 months. antibody to t antigen became evident later in most inoculated monkeys but had a marked variable course and did not correlate well with tumor production. the antib ... | 1983 | 6304763 |
| the detection of jc viral genome in owl monkey tumors. | the jc viral genome is integrated into the cellular dna of brain tumors from owl monkeys inoculated intracranially with jc virus 16-36 months prior to the development of the tumors. normal brain tissue of the animals did not contain the viral genome. for at least two tumors, restriction endonuclease analysis of the tumor dna indicates that there is a complete copy of the viral genome present. integration of the genome in all but one of the tumors was at only one or only a limited number of sites ... | 1983 | 6304764 |
| jc virus t protein expression in owl monkey tumor cell lines. | four owl monkey tumor cell lines were tested for the presence of jcv early gene products. owl 26 was the only cell line in which large t protein could be immunoprecipitated using cross-reactive anti-sv40 hamster tumor sera. small t protein could not be detected in any of the four cell lines. the monoclonal antibody cl 122, directed against the host-cell 53k protein, could bind the sv40-t-53k host protein complex in human embryonic kidney cells transformed by sv40. however, the cl 122 antibody on ... | 1983 | 6304765 |
| structural proteins of herpesvirus saimiri. | herpesvirus saimiri particles were purified from productively infected owl monkey kidney cell cultures, and the virion polypeptides were analyzed by polyacrylamide gel electrophoresis. a total of 21 predominant proteins were found in lysates of h. saimiri 11 particles by coomassie blue staining or by [35s]methionine labeling and autoradiography; all proteins were between 160,000 and 12,000 daltons in size. they are most probably virion constituents, as most of them were precipitated by immune se ... | 1983 | 6312078 |
| construction of replication-competent herpesvirus saimiri deletion mutants. | dna fragments derived from the left end of herpesvirus saimiri 11 l-dna were cloned in escherichia coli by using vector pbr322. deletions were introduced within a cloned 7.4-kilobase-pair sequence by using restriction endonucleases that cut once or twice within this sequence. permissive owl monkey kidney-cultured cells were transfected with parental strain 11 viral dna plus cloned dna with specific sequences deleted. by screening the progeny of these transfections with a limiting-dilution spot h ... | 1984 | 6319734 |
| brain tumors of owl monkeys inoculated with jc virus contain the jc virus genome. | the dna from astrocytomas that developed in adult owl monkeys 16 to 36 months after intracranial inoculation with jc virus (jcv) was examined for the presence of the jcv genome by hybridization to cloned jcv dna. the jcv genome was found to be integrated into the cellular dna in all tumors examined. there was no jcv dna in normal, uninvolved brain tissue from the same animals. integration of the genome occurred at a limited number of sites in the cellular dnas, indicating a clonal origin for the ... | 1984 | 6321769 |
| plasmodium falciparum: comparison of in vitro growth of knobby and knobless isolates. | variants (k-) of three strains of plasmodium falciparum which do not produce the erythrocyte surface alterations that have been called knobs have been compared with their wildtype knobby (k+) parents. the k- variants achieve higher parasitemias, incorporate radiolabeled isoleucine more rapidly, and produce a higher percentage of multiply-infected cells than do their k+ parents. nevertheless, immune owl monkey sera cause approximately the same percentage inhibition of growth of both k+ and k- org ... | 1983 | 6340540 |
| immunization of owl monkeys to plasmodium falciparum with merozoites from cultures of a knobless clone. | summary aotus trivirgatus monkeys of karyotype 2 were treated as follows. three received two injections of purified merozoites of a knobless (k-) clone of plasmodium falciparum with muramyl dipeptide as adjuvant; three received similar injections but with merozoites of a wild-type knobby (k+) strain; three controls received mdp with human erythrocytes in the amounts estimated to be present as contaminants in the merozoite preparations. a month after the second injection all nine monkeys were ino ... | 1983 | 6346229 |
| plasmodium falciparum: protein antigens identified by analysis of serum samples from vaccinated aotus monkeys. | serum samples from aotus trivirgatus subsp. griseimembra monkeys obtained at different stages of a vaccination experiment were analyzed for total antibody titer to plasmodium falciparum and were used for identifying protective antigens of the human malaria parasite. total malarial antibody titers were higher in serum samples from protected monkeys (vaccinated with antigen in an adjuvant) than in those from unprotected monkeys (vaccinated with either antigen or adjuvant only). parasite proteins w ... | 1984 | 6360901 |
| reactogenicity of a malaria merozoite antigen in aotus monkeys compared with the effects caused by two new adjuvants, cp-20,961 and [b30]-mdp. | six aotus trivirgatus monkeys were included in a clinical study to compare the adverse reactions caused by a plasmodium falciparum antigen and 2 adjuvants, a lipoidal amine, cp-20,961, and a muramyl dipeptide derivative, [b30]-mdp. two monkeys were given 2 intramuscular injections, 3 weeks apart, of 1 of these vaccine components. both the antigen and the two adjuvants caused local and general reactions as well as hematological and biochemical changes. except for an up to 60% rise in leukocyte co ... | 1983 | 6361979 |
| complement activation by the surface of plasmodium falciparum infected erythrocytes. | the surface of trophozoite-stage plasmodium falciparum infected erythrocytes will, in the presence of immune human or owl monkey serum, activate the classical complement pathway. this was demonstrated with a sensitive, enzyme-linked immunosorbent assay which detects the complex, c1s-c1 inhibitor, which is only generated when the classical pathway is activated. a second enzyme-linked immunosorbent assay, as well as covaspheres coated with affinity-purified anti-c3, showed that immune activation o ... | 1984 | 6369119 |
| malaria parasites do not contain or synthesize sialic acids. | the capacity of plasmodia to synthesize sialic acids was investigated by adding radioactive acetate to short-term in vitro cultures of the intraerythrocytic asexual forms of three malaria parasites (the human malaria plasmodium falciparum in aotus trivirgatus erythrocytes; the simian malaria p. knowlesi in rhesus monkey erythrocytes; the rodent malaria p. berghei in mouse erythrocytes) and to cultures of extracellular zygotes of the avian malaria p. gallinaceum. radioactive acetate was added to ... | 1984 | 6370820 |
| comparison of in vitro and in vivo antimalarial activities of 9-phenanthrenecarbinols. | analysis of the antimalarial activity of a selected series of 17 9-phenanthrenecarbinols against cultured strains of plasmodium falciparum and against p. berghei in mice following oral administration indicated that the rankings of activities within the series were influenced by substituents on the 9-carbinol and the route of administration. compounds with alkylamino-alkyl groups were ranked as most active by an in vitro screening system which assayed activity against chloroquine-sensitive and ch ... | 1984 | 6372713 |
| synthesis of merozoite proteins and glycoproteins during the schizogony of plasmodium falciparum. | we have investigated the protein and glycoprotein content of plasmodium falciparum merozoites by metabolically labeling cultures of schizont-stage parasites with [35s]methionine or with [3h]glucosamine followed by incubation in nonradioactive medium to allow the schizonts to mature into merozoites, infect new erythrocytes, and develop into ring-stage parasites. the ring stages were separated from schizonts by sedimentation through percoll. labeled proteins were resolved by sodium dodecyl sulfate ... | 1984 | 6374450 |
| long term cultivation of plasmodium falciparum in aotus trivirgatus erythrocytes. | the erythrocytes of the colombian owl monkey aotus trivirgatus griseimembra can be used for the long-term in vitro cultivation of plasmodium falciparum employing a modified trager -jensen method. cultures are grown in hepes-buffered rpmi-1640 using a 4% suspension of monkey erythrocytes and 10% pooled heat-inactivated human ab serum, with initial parasitemias in a range between 0.2 and 0.5%. adaptation of new strains from human erythrocytes cultures can be performed by simply subculturing from h ... | 1984 | 6375405 |
| plasmodium falciparum: comparative analysis of antigens from continuous in vitro cultured and in vivo derived malarial parasites. | a comparison of metabolically labeled proteins from continuous in vitro and in vivo derived plasmodium falciparum revealed both similarities and differences. metabolic labeling of synchronized cultures showed that the uptake of label increased as the parasites matured from the ring to the schizont stage in both cultures. also, in both continuous in vitro and in vivo derived cultures, prominent high-molecular-weight proteins were synthesized during the late developmental stages. however, the cont ... | 1984 | 6383858 |
| susceptibility of different populations of colombian aotus monkeys to the fcb-1 strain of plasmodium falciparum. | p6udies of susceptibility to the fcb-1 strain of plasmodium falciparum from colombia were conducted in three different groups of aotus monkeys. the results indicated that aotus trivirgatus griseimembra from the north of the magdalena valley were the most susceptible host. a. t. griseimembra from the central magdalena valley appeared to be less susceptible to infection, while aotus monkeys from the eastern andes were even more resistant to infection. serum electrophoretic studies were not useful ... | 1984 | 6385739 |
| two distinct forms of beta 2-microglobulin in different races of owl monkey (aotus trivirgatus). | | 1984 | 6386678 |
| a role for rheumatoid factor enhancement of plasmodium falciparum schizont inhibition in vitro. | studies were undertaken to determine whether rheumatoid factor (rf) was present in immune human and aotus trivirgatus monkey sera which inhibited plasmodium falciparum schizonts in vitro and to determine whether rf could be responsible for or contribute to merozoite agglutination in the parasite inhibition test. additional studies were conducted to determine the effect of exogenous rf on schizont inhibition when used alone or in conjunction with immune or normal sera. rf was not detected in any ... | 1984 | 6389357 |
| comparative infectivity of knobless and knobby clones of plasmodium falciparum in splenectomized and intact aotus trivirgatus monkeys. | in two experiments, two knobless (k-) and two knob-producing (k+) clone-cultures of plasmodium falciparum, fcr-3/gambia strain, were injected into four aotus trivirgatus monkeys. the parasitemia in the k(-)-infected splenectomized (s-) monkey rose to a peak of 2.1% on the 16th day, while it reached only 0.7% at the same time in the k+ infected s- animal. passage from these animals (karyotype vi) into two intact (s+), naive monkeys of karyotype iii resulted in very light infections somewhat highe ... | 1984 | 6395532 |
| plasmodium falciparum merozoite vaccine in aotus monkeys. an evaluation of the tolerableness of three types of adjuvants. | eight aotus trivirgatus monkeys were included in a comparative study of adverse reactions caused by 3 types of malarial vaccine. the antigen consisted of late schizonts and merozoites combined with each of 3 adjuvants, a lipoidal amine cp-20,961, a muramyl dipeptide derivative [b30]-mdp, or freund's complete adjuvant (fca); 3 monkeys received cp-20,961 and 3 [b30]-mdp, whereas the fca vaccine was given to 2 animals. all the vaccine combinations caused some adverse reactions, but their nature and ... | 1984 | 6396835 |
| infection of female squirrel monkeys (saimiri sciureus) with trichomonas vaginalis as a model of trichomoniasis in women. | marmosets, tamarins, owl monkeys, and squirrel monkeys were inoculated intravaginally with trichomonas vaginalis. the latter animal species was most susceptible, trichomonads being recovered from four of six monkeys for periods ranging usually up to one month. vaginal discharge was seen in most infected animals but polymorphonuclear leucocytes were rare. infected animals developed serum igg antibody responses and also local igg and iga responses, the latter occurring sometimes on reinoculation i ... | 1983 | 6409346 |
| altered lipoprotein metabolism in spontaneous vitamin e deficiency of owl monkeys. | certain owl monkeys (aot) develop spontaneous hemolytic anemia that responds to vitamin e. the anemia is associated with red blood cell lipid peroxidation and altered red blood cell membrane lipid composition. to investigate these changes, plasma lipid and lipoprotein profiles were characterized in anemic, anemia-susceptible, and anemia-resistant aot. the plasma vitamin e and vitamin a concentrations were assessed as an index of fat absorption and the effect of corn oil supplementation and vitam ... | 1983 | 6417997 |
| endothelial repair following nd:yag laser injury. | effects of different energy levels (1.2, 2.0, 2.8, 4.0 mj) of a mode-locked nd:yag laser beam focused directly on the corneal endothelium were evaluated in rabbit, cat, and owl monkey. the endothelial lesion observed by specular microscopy at 10 min; 8, 16, and 24 hr; 3, 5, 7, and 21 days measured up to 0.8 mm in diameter. it showed focal destruction of descemet's membrane and a larger area of endothelial denudation corresponding probably to the shock wave generated by the plasma. the size of th ... | 1984 | 6430839 |
| cortical connections of the middle temporal visual area (mt) and the superior temporal cortex in owl monkeys. | the connections of the middle temporal visual area (mt) and an adjoining superior temporal visual region (st) were investigated with injections of 3h-proline and horseradish peroxidase (hrp) in adult owl monkeys. injections in mt revealed an extensive pattern of intrinsic connections that appeared to be organized in a series of bands across mt. mt was found to project ipsilaterally to an array of visual areas including the first (v i) and second (v ii) visual areas, the dorsolateral visual area ... | 1984 | 6480909 |
| comparison of brain structure volumes in insectivora and primates. iv. non-cortical visual structures. | the relative size of the eyes, optic nerves, chiasms and tracts, and of the dorsal nucleus of the lateral geniculate body is distinctly larger in primates than in (theoretically) isoponderous insectivora. within insectivora, the relative size is lowest in moles, medium in shrews and hedgehog-like tenrecs, and largest in hedgehogs. within primates, all relative sizes are on the average larger in simians than in prosimians: the eyes to a small degree, the lateral geniculate bodies moderately and t ... | 1984 | 6481154 |
| receptive-field properties of neurons in middle temporal visual area (mt) of owl monkeys. | response properties of single neurons in the middle temporal visual area (mt) of anesthetized owl monkeys were determined and quantified for flashed and moving bars of light under computer control for position, orientation, direction of movement, and speed. receptive-field sizes, ranging from 4 to 25 degrees in width, were considerably larger than receptive fields with corresponding eccentricities in the striate cortex. neurons were highly binocular with most cells equally or nearly equally acti ... | 1984 | 6481441 |
| exogenous na-hyaluronate in the anterior chamber of the owl monkey and its effect on the intraocular pressure. | exogenous, ultrapure (sterile, pyrogen-free), non-inflammatory fraction of na-hyaluronate (nif-naha) was introduced into the anterior chamber of owl monkeys (aotus trivirgatus), replacing approximately 48% or 77% of the aqueous humor and creating post-injection intraocular pressures (iops) below normal (5-10 mmhg) or above normal (40-60 mmhg), respectively. five different molecular weight samples (mw 1.7, 3.4, 3.7, 4.5 and 4.9 x 10(6)) were used. all solutions contained 1% nif-naha and, because ... | 1984 | 6489468 |
| [laboratory maintenance and various experimental uses of the night monkey, aotus]. | | 1984 | 6494511 |
| interhemispheric connections of visual cortex of owl monkeys (aotus trivirgatus), marmosets (callithrix jacchus), and galagos (galago crassicaudatus). | interhemispheric connections of visual cortex were studied in owl monkeys, marmosets, and galagos after multiple injections of horseradish peroxidase into one cerebral hemisphere. areal patterns of connections were revealed in sections of cortex that was flattened and cut parallel to the surface. results were related to the locations of known visual areas, especially in owl monkeys, in which more visual areas have been established. the connection patterns in owl monkeys and marmosets are very si ... | 1984 | 6520237 |
| direction and orientation selectivity of neurons in visual area mt of the macaque. | we recorded from single neurons in the middle temporal visual area (mt) of the macaque monkey and studied their direction and orientation selectivity. we also recorded from single striate cortex (v1) neurons in order to make direct comparisons with our observations in area mt. all animals were immobilized and anesthetized with nitrous oxide. direction selectivity of 110 mt neurons was studied with three types of moving stimuli: slits, single spots, and random-dot fields. all of the mt neurons we ... | 1984 | 6520628 |
| comparative chromosomal mapping of the owl monkey serum albumin gene. | we have mapped the albumin locus (alb) in the owl monkey, aotus trivirgatus, using a cloned human albumin gene probe, pchsa 33-1. rodent-owl monkey somatic cell hybrids were used to map the owl monkey albumin locus in three subgroups of aotus, karyotypes ii, v, and vi. segregation analysis of the molecular hybridization pattern of pchsa 33-1 in the somatic cell hybrids indicated that the albumin locus maps to chromosome 9 of owl monkey karyotype ii, chromosome 12 of karyotype v, and chromosome 1 ... | 1984 | 6548952 |
| eosinophilic myelocytoma in an owl monkey (aotus trivirgatus). | a mass found in the anterior mediastinum at necropsy of an adult female owl monkey (aotus trivirgatus) was morphologically consistent with an eosinophilic myelocytoma. lymph nodes, kidneys, bone marrow, and other tissues were diffusely infiltrated by neoplastic cells. intracellular and extracellular charcot-leyden crystals were present in the neoplasm. | 1983 | 6574290 |
| in vivo evaluation of ocular inserts of hydrogel impregnated with antibiotics for trachoma therapy. | sustained release of antibiotics from hydrogel matrices in the eye was studied for the purpose of developing a new method for trachoma therapy. copolymers of n-vinylpyrrolidone were moulded into an ocular insert and impregnated with erythromycin or erythromycin estolate. the antibiotic-hydrogel inserts completely suppressed the chlamydia trachomatis infection in the owl monkey eyes. the drug elution rates were a little lower in vivo than in vitro. by comparison of the drug elution rate in the hu ... | 1983 | 6640048 |
| the relation of corpus callosum connections to architectonic fields and body surface maps in sensorimotor cortex of new and old world monkeys. | corpus callosum connections of parietal and motor cortex were studied in new world owl monkeys (aotus trivirgatus) and old world macaque monkeys (macaca fascicularis) after multiple injections of 3h-proline and horseradish peroxidase, hrp, into one cerebral hemisphere, and extensive microelectrode mapping of architectonic areas 3b, 1, and 2 of the other hemisphere. results were obtained both from parasagittal brain sections cut orthogonal to the brain surface and from sections from flattened bra ... | 1983 | 6643713 |
| progression of change following median nerve section in the cortical representation of the hand in areas 3b and 1 in adult owl and squirrel monkeys. | in an earlier study (neuroscience 8, 33-55, 1983), we found that the cortex representing the skin of the median nerve within parietal somatosensory fields 3b and 1 was completely occupied by 'new' inputs from the ulnar and radial nerves, 2-9 months after the median nerve was cut and tied in adult squirrel and owl monkeys. in this report, we describe the results of studies directed toward determining the time course and likely mechanisms underlying this remarkable plasticity. highly detailed maps ... | 1983 | 6646426 |
| species-specific homogeneity of the primate alu family of repeated dna sequences. | we have determined the base sequence of several cloned alu family members from the dnas of a new world monkey (owl monkey) and a prosimian (galago). the three owl monkey alu family members reported here belong to a single 300 base pair consensus sequence which closely resembles the human alu family consensus. the galago alu family members can best be represented as belonging to either of two related but distinct consensus sequences. one of the two galago alu family subgroups (type i) more accura ... | 1983 | 6647031 |
| hemolytic complement measurement in eleven species of nonhuman primates. | a microtiter system was used to measure hemolytic complement levels in serum from eleven nonhuman primate species. the species studied were macaca mulatta (rhesus macaque), macaca radiata (bonnet macaque), macaca nemestrina (pig-tailed macaque), macaca fascicularis (crab-eating macaque), macaca speciosa (stumptailed macaque), papio cynocephalus (yellow baboon), papio anubis (olive baboon), cercopithecus aethiops (african green monkey), aotus trivirgatus (owl monkey), ateles fusceps robustus (spi ... | 1983 | 6659335 |
| toxicity and efficacy of the antileishmanial drug meglumine antimoniate in the owl monkey (aotus trivirgatus). | | 1983 | 6674468 |
| anosmia and aggression in male owl monkeys (aotus trivirgatus). | adult owl monkeys behaved aggressively when paired with unfamiliar members of the same sex. males showed the greatest aggressive responses. when plugs containing bismuth iodoform paste were inserted into the nasal passages of male owl monkeys they fought less readily and showed less contact aggression. although intermale aggression was not abolished anosmic males spent longer in proximity and showed an increase in olfactory inspections. control experiments confirmed that the technique used to in ... | 1983 | 6684305 |
| the myoglobin of primates: the night monkey, aotes trivirgatus (cebidae, platyrrhini, anthropoidea). | the amino acid sequence of the myoglobin of the south american night monkey, aotes trivirgatus, is identical to that of the marmoset (callithrix jacchus [1]) except for residue 21 which is isoleucine in the marmoset, like in all other anthropoids, but valine in aotes. analysis of a possible pathway of the evolution of aotes myoglobin using 18 known primate myoglobin sequences [2-5] supports the classification of the night monkey within anthropoidea and platyrrhini but it indicates that this spec ... | 1984 | 6692912 |
| pathology of hepatitis a infection in the owl monkey (aotus trivirgatus). | sequential liver biopsies of owl monkeys that had been experimentally infected with one of two strains of hepatitis a virus (hm-175 or pa-33) were examined for histopathologic alterations. preinoculation biopsies were normal with only occasional minimal mononuclear cell infiltrates in portal tracts and hepatic lobular parenchyma. histopathologic features that were present in biopsies taken during the period of elevated serum alanine aminotransferase activity (16-43 days after the intravenous ino ... | 1984 | 6711675 |
| immune response of owl monkeys to topical vaccination with irradiated chlamydia trachomatis. | the conjunctivae of owl monkeys were topically vaccinated with purified chlamydia trachomatis organisms that had been inactivated by 60co irradiation and lyophilized onto an inert carrier. vaccinated monkeys developed antibody in serum and tears, while control animals given a placebo had no detectable titers. when challenged 35 days after the start of administration of the vaccine, all monkeys showed evidence of infection. the vaccinated group had a longer course of disease and more ocular disch ... | 1984 | 6715899 |
| 5-fluorouracil and glaucoma filtering surgery: i. an animal model. | failure of a glaucoma filtering procedure commonly results from scarring at the surgical site. fibroblasts play an important role in the scarring process. 5-fluorouracil is an antimetabolite capable of inhibiting fibroblast proliferation. we tested the ability of 5-fluorouracil to inhibit cicatrization at the filtering site in an experimental model. posterior lip sclerectomies were performed in each eye of ten normal owl monkeys. postoperatively, one eye of each animal received subconjunctival i ... | 1984 | 6717922 |
| use of gabor elementary functions to probe receptive field substructure of posterior inferotemporal neurons in the owl monkey. | the large receptive fields of inferotemporal neurons in the owl monkey were studied with visual stimuli whose luminance profiles were one-dimensional gabor functions, i.e. sinusoidal gratings within gaussian envelopes. the members of one set of such patterns all had a full bandwidth at half-amplitude of 0.8 octaves, but different center frequencies and spatial extents. these spatially restricted stimuli were ideal for determining whether one or more than one spatial frequency band projected onto ... | 1984 | 6719837 |
| somatosensory cortical map changes following digit amputation in adult monkeys. | the cortical representations of the hand in area 3b in adult owl monkeys were defined with use of microelectrode mapping techniques 2-8 months after surgical amputation of digit 3, or of both digits 2 and 3. digital nerves were tied to prevent their regeneration within the amputation stump. successive maps were derived in several monkeys to determine the nature of changes in map organization in the same individuals over time. in all monkeys studied, the representations of adjacent digits and pal ... | 1984 | 6725633 |
| activated partial thromboplastin time of owl monkey (aotus trivirgatus) plasma. | owl monkey plasma samples produced short, reproducible activated partial thromboplastin times, similar to those obtained with samples from many other mammalian species. this was an apparent contradiction to an earlier report of long irreproducible activated partial thromboplastin times from owl monkey samples. the discrepant data could not be explained by differences in anticoagulants (citrate or oxalate), assay reagents (partial thromboplastin with either diatomaceous earth or ellagic acid), or ... | 1984 | 6748609 |
| plasmodium falciparum merozoite vaccination in aotus monkeys recovered spontaneously from p. falciparum infection: a clinical study. | 6 aotus trivirgatus monkeys, which had all spontaneously recovered from an experimentally induced plasmodium falciparum infection, were included in a clinical study concentrating on possible adverse reactions caused by a vaccine using late schizonts and merozoites as an antigen a synthetic compound, cp-20,961, as an adjuvant. two monkeys in the study were vaccinated once, 2 twice, 1 received adjuvant alone and 1 served as a saline control. local and general inflammatory reactions as indicated by ... | 1982 | 6755660 |
| is dna methylation responsible for mammalian x chromosome inactivation? | mohandas et al. (1981) have proposed that mammalian x chromosome inactivation involves segmental methylation of cytosine residues in the dna at multiple sites along the x chromosome. using antibodies specific for 5-methylcytosine, we have found no detectable difference in the extent of methylation of the dna in the two x chromosomes of owl monkey or human females. thus inactivation (facultative heterochromatization) of the x chromosome is not due to, or associated with, intense dna methylation c ... | 1982 | 6756802 |
| patterns of connections from the striate cortex to cortical visual areas in superior temporal sulcus of macaque and middle temporal gyrus of owl monkey. | double label-emulsion autoradiography has been used in rhesus monkeys to study cortico-cortical connections, arising from two separate sites of the striate cortex, and going in the same hemisphere into the cortex in the medial part of the posterior (or ventral) bank of the superior temporal sulcus (area sts). the projections from a single cortical locus are segregated into several patches of labeled terminals in layers iii-iv, which form bands in consecutive sections. fields of distribution of t ... | 1980 | 6766146 |
| aqueous humor changes after experimental filtering surgery. | we studied aqueous humor of rhesus and owl monkeys for its effect on the growth of subconjunctival fibroblasts in tissue culture. aqueous humor samples obtained before glaucoma surgery inhibited the initiation of growth of fibroblasts. however, postoperative aqueous humor samples supported growth of fibroblasts. the change in aqueous humor physiology lasted for up to two months after glaucoma surgery. our study indicated that possibly material added to the postoperative aqueous humor inactivates ... | 1980 | 6766671 |