| [bacterial and fungal rhino-sinusitis]. | | 1977 | 339339 |
| aspergillus pneumonia--a cluster of four cases in an intensive care unit. | four cases of aspergillus pneumonia occurred in an intensive care unit within a short period. clusters of cases of invasive aspergillosis are rare and have usually been attributed to excessive contamination of the environment. extensive environmental studies were, however, negative. three of the cases were diagnosed ante mortem. one patient survived after early initiation of treatment with amphotericin b. | 1977 | 339374 |
| [virulence and biochemical activity of aspergillus fumigatus strains isolated from cow fetuses]. | tested was the virulence of 20 strains of aspergillus fumigatus isolated from cow fetuses. all laboratory mice injected with them died, and the pregnant guinea pigs aborted. it was demonstrated that these strains contain exogenic and endotoxic substances which are extracted effectively with alcohol and ether. the mould cultures showed proteolytic, amylolytic, cellulose, and organic acid activity. the biochemical and pathogenic potential of the strains were of great importance for causing abortio ... | 1977 | 339512 |
| occurrence of aspergillus fumigatus during composting of sewage sludge. | aspergillus fumigatus, a medically important fungal opportunist and respiratory allergen, was isolated from woodchips and sewage sludge used in the production of compost at the u.s. department of agriculture's composting research facility in beltsville, md. it was also regularly isolated as a dominant fungus during forced aeration composting and after 30 days in an unaerated stationary curing pile; in both cases, the fungus was found in pile zones with temperatures less than 60 degrees c. compos ... | 1977 | 339835 |
| the effect of 1,4-diaminobutanone on the stability of ornithine decarboxylase from aspergillus nidulans. | 1,4-diaminobutanone, a competitive inhibitor of ornithine decarboxylase in aspergillus nidulans, is able to increase the half-life of this enzyme and thus stimulate an increase in its activity in vivo. it also protects ornithine decarboxylase against proteolysis by chymotrypsin in vitro. | 1977 | 339910 |
| polyamine stimulation of in vivo rates of macromolecular synthesis in a putrescine auxotroph of aspergillus nidulans. | | 1978 | 340271 |
| cell-pool tryptophan levels during ergot alkaloid formation in aspergillus fumigatus. | | 1977 | 340382 |
| diagnosis of invasive pulmonary aspergillosis by fiberoptic transbronchial lung biopsy. | | 1978 | 340719 |
| genetic analysis of mutations of low (rec) and very high (pop) mitotic-recombination frequency in aspergillus nidulans. | | 1977 | 340885 |
| extranuclear recombination in aspergillus nidulans: closely-linked multiple chloramphenicol- and oligomycin-resistance loci. | a nuclear, chloramphenicol-sensitive mutant cas-1 has been isolated which is cross sensitive to a number of drugs, including oligomycin and cycloheximide. approximately one-third of the chloramphenicol-resistant mutants isolated from mutagenized conidia of this strain were found to be extranuclear, and exhibited a variety of phenotypes. one of these mutants, designated (camb51), was slow growing on drug-free medium and recombined at low frequency with the previously described mutant (cama112) (g ... | 1977 | 340908 |
| relationship between proteolytic activity of aspergillus fumigatus and the fungus invasiveness of mouse brain. | | 1977 | 340955 |
| natural occurrence of aspergillus fumigatus in cane sugar mills. | the environmental distribution of aspergillus fumigatus in 2 cane-sugar mills and one paper factory in northern india is compared with 2 localities in delhi. the preponderance of the species at the u.d. sugar mills, shamli, was contrary to its low prevalence in the university of delhi campus and at subzimandi, the vegetable and fruit market of delhi. aspergillus fumigatus accounted for 42.5% of the total aerial fungal colony counts recorded in the shamli mills as against 2% in delhi. the predomi ... | 1977 | 341368 |
| [experimental studies in animals on the influence of fluocortin butylester on the course of generalized infections (author's transl)]. | the influence of butyl 6alpha-fluoro-11beta-hydroxy-16alpha-methyl-3,20-dioxo-1,4-pregnadien-21-oate (fluocortin butylester, vaspit), a new corticosteroidal compound with a marked dissociation between local antiinflammatory and systemic action, upon resistance against infections was studied in experimental bacterial and fungal infections in mice. the results of the experiments showed, that fluocortin butylester, even after repeated s.c. or oral administration of dosages up to 100 mg/kg did not d ... | 1977 | 341900 |
| treatment with antifungal vaccines. | | 1977 | 342190 |
| [comparison of radioimmunoassay techniques in the detection of ige and igg antibody activity against aspergillus fumigatus antigens]. | | 1978 | 342606 |
| [studies on the toxin of aspergillus fumigatus. viii. biological properties of asp-hemolysin (author's transl)]. | | 1977 | 342741 |
| [apropos of a case of invasive pulmonary aspergillosis with subadjacent aspergilloma]. | | 1977 | 343198 |
| "fruiting bodies" of aspergillus on the skin of a burned patient. | a case of a young man with an extensive total-body-surface burn complicated by wound infection is presented. one of the fungal organisms in the cutaneous burn wound had morphologically characteristic and diagnostic features by development of conidiophores ("fruiting bodies") pathognomonic of aspergillus spp. | 1978 | 343572 |
| atmospheric mold spores in tehran, iran. | plate method, using modified sabouraud and littman oxgall agra media, was used to study atmospheric mold spores in tehran, iran, for a complete year. twenty-two different genera of molds were identified and counted. of these, yeast, penicillium, cladosporium, rhodotorula, alternaria, stemphylium and aspergillus were the most abundant and were seen all year 'round. other genera were observed seasonally and in small numbers. | 1978 | 343658 |
| aspergillosis of the frontal sinus. | aspergillus is the most common fungal infection of the paranasal sinuses and usually appears as a chronic disease in an otherwise healthy person. previously reported cases have involved the maxillary sinus alone in the majority of cases. to my knowledge, isolated frontal sinus aspergillosis has not been previously reported. a frontal osteoplastic flap approach was used to expose a fungus ball in the right frontal sinus of a healthy 69-year-old man. histologic preparations and fungal cultures sho ... | 1978 | 343775 |
| pulmonary aspergilloma. | | 1977 | 343802 |
| meiotic recombination in a duplication strain of aspergillus nidulans. | | 1978 | 344133 |
| infection in the renal transplant patient. | | 1978 | 344880 |
| the effects of coumarin on the frequency of deletions in a duplication strain of aspergillus nidulans. | strains of a. nidulans with a chromosome segment in duplicate show instability resulting from deletions in either of the duplicate segments. in dp (i, ii) strains, with the terminal segment of ir attached terminally to iir, spontaneous deletions occur most frequently, though not exclusively, from the translocated segment. coumarin, at concentrations which did not affect viability viability or growth rate, enhanced the instability of dp (i, ii) strains by selectively increasing only the deletion ... | 1978 | 345093 |
| supersuppressors in aspergillus nidulans. | simultaneous reversion of mutations in two different aspergillus nidulans loci ada and metg was found to be due monogenic suppressor mutations. preliminary evidence for the existance of supersuppressors in a. nidulans is presented. | 1978 | 345096 |
| restriction endonuclease cleavage map of mitochondrial dna from aspergillus nidulans. | mitochondrial dna of the ascomycete fungus aspergillus nidulans, a circular molecule of 31 500 base pairs, is cleaved by restriction endonucleases eco r i, hind ii, hind iii and bgl ii into 3, 7, 9 and 5 fragments, respectively. the relative positions of the cleavage sites could be mapped by analysis of fragments obtained by double enzyme digestions of whole dna and by complete and partial redigestion of isolated restriction fragments. | 1978 | 345242 |
| "aspergillus fumigatus"--a pathogen and allergen. | aspergillus fumigatus is being increasingly recognised as causing various pathological conditions in man, animals and birds. in man the use of antibiotics has increased the importance of fungi in various clinical situations as opportunistic infective agents. in man, cavities in the lung are often (20 per cent) colonised by aspergillus species, nearly always a. fumigatus. the mycetoma so formed can be specifically diagnosed by finding precipitating antibodies to a. fumigatus in the serum. in an a ... | 1977 | 345783 |
| collection and cultivation of and phagocytosis by pulmonary macrophages obtained from hysterectomy-derived pigs. | methods were developed for procuring phagocytically active macrophages from porcine lung with minimal damage to respiratory tissues. procedures included anesthetizing, surgically introducing a t-shaped tracheal catheter, and repeatedly flushing the respiratory tract. macrophages collected in this manner were characterized as to numbers, types, and phagocytic activity, nonselective lavage of the pulmonary airways of unstimulated and stimulated (evoking agent: thioglycolate medium) animals yielded ... | 1978 | 345891 |
| disseminated petriellidosis (allescheriosis). | disseminated infection by petriellidium (allescheria) boydii occurred in an immunosuppressed renal allograft recipient. a probable airborne pulmonary infection underwent hematogenous spread to the brain, thyroid, and heart. the organism develops septate, branching hyphae in tissue and may be misdiagnosed as aspergillus. the basic pathologic lesions are necrosis with a predominantly polymorphonuclear leukocytic reaction and abscess formation, and a mild granulomatous response with macrophages and ... | 1978 | 345997 |
| bilateral endogenous endophthalmitis successfully treated with 5-fluorocytosine. | | 1977 | 346120 |
| subunit composition of fatty acid synthetase from fungi. | | 1978 | 346409 |
| amino acid analogs iv:4-fluoroisoleucine. | 4-fluoroisoleucine was produced by ammonolysis of 2-bromo-4-fluoro-3-methylpentanoic acid, which resulted from the bromofluorination of 4-methyl-2-pentenoic acid. it did not inhibit plasmodium berghei in mice at 640 mg/kg and was not toxic to the animals. the fluoroamino acid inhibited aspergillus niger, trichoderma viride, myrothecium verrucaria, trichophyton mentagrophytes, and mucor mucedo in czapek solution agar at a concentration between 10(4) and 10(3) microgram/ml. growth of escherichia ... | 1978 | 347050 |
| mutations in nira gene of aspergillus nidulans and nitrogen metabolism. | | 1978 | 347305 |
| damage to hyphal forms of fungi by human leukocytes in vitro. a possible host defense mechanism in aspergillosis and mucormycosis. | evidence suggests that neutrophils are important in host defenses against invasive aspergillosis and mucormycosis, although hyphae in these lesions are too large to be phagocytized. interactions of neutrophils with hyphae of aspergillus fumigatus and rhizopus oryzae were studed in vitro. light and electron microscopic observations indicated that neutrophils attached to and spread over the surfaces of hyphae, even in the absence of serum. this was followed by dramatic morphologic changes which su ... | 1978 | 347942 |
| quantitative determination of alpha-amylase in glucoamylase preparations. | | 1978 | 347977 |
| specific ige estimations by rast in japanese asthmatics compared with skin, passive transfer and bronchial provocation tests. | 198 asthmatics and twenty healthy persons were studied by rast and in vivo tests with four common inhalant allergens. (a) higher rast classes were elicited with mite (dermatophagoides farinae) extract and lower classes with other allergens. the agreement between positive rast and skin or p-k tests was highest with the mite extract. rast sensitivity was dependent on the kinds of allergens and was most sensitive to mite extract. positive rast was most closely related to the prick test reactions. ( ... | 1978 | 348345 |
| electrical impedance measurements: rapid method for detecting and monitoring microorganisms. | a conceptually simple and east-to-use technique is described that uses continuous impedance measurements for automated monitoring of microbial growth and metabolism. the method has been applied to a wide range of microorganisms. optical clarity is not required. the sensitivity and reproducibility of the method are demonstrated. the mechanism whereby microbial growth alters the impedance of the medium is discussed, as well as potential applications of the method to clinical microbiology. | 1978 | 348718 |
| serum ige and igg antibody activity against aspergillus fumigatus as a diagnostic aid in allergic bronchopulmonary aspergillosis. | serum ige and igg antibody activity against aspergillus fumigatus was measured in 3 groups of subjects by 2 different immunologic methods. group a consisted of 23 patients with allergic bronchopulmonary aspergillosis (abpa). group b was composed of 19 patients with extrinsic asthma who had marked immediate type skin reactivity to a. fumigatus (prick skin test, 3 or 4+) but no other manifestation of abpa. group c, the control group, was composed of 12 healthy subjects. two immunological methods, ... | 1978 | 350109 |
| mycotoxins produced by aspergillus fumigatus isolated from silage. | results are presented which show that aspergillus fumigatus was one of the predominant fungi contaminating moldy silage. growth of a. fumigatus on silage appeared to depend on a preliminary aerobic fermentation by other natural microflora in silage. the clavine alkaloid, fumigaclavine a, and a new clavine alkaloid designated fumigaclavine c were produced by a. fumigatus. the ld50 of fumigaclavine c was approximately 150 mg/kg oral dose in day-old cockerels. | 1977 | 350117 |
| sporulation competence in aspergillus nidulans: a role for iron in development. | there is a difference in the response of dna from mycelial extracts of aspergillus nidulans to hot acid hydrolysis depending upon the state of sporulation competence. the dna in incompetent culture mycelia is not hydrolyzable while the dna in competent culture is hydrolyzable. the inhibition of dna hydrolysis is due to the presence of iron. although the concentration of iron decreases in mycelia during growth, there is sufficient iron present in competent mycelia to inhibit dna hydrolysis. the c ... | 1978 | 350417 |
| airborne aspergillus fumigatus levels outside and within a large clinical center. | most considerations of aspergillus fumigatus prevalence have implied that patterns of occurrence observed within london hospitals are generally applicable. since prevalence data are almost nonexistent elsewhere, this assumption remains untested. to provide a comparison relevant to north america, we have monitored thermotolerant fungi outside as well as at two sites within the university hospital, ann arbor, michigan, during one year. collections were made with paired andersen samplers and malt a ... | 1978 | 350933 |
| what does a fungus among us really mean? | | 1978 | 350935 |
| a comparison of the prevalence of sensitization to aspergillus antigens among asthmatics in cleveland and london. | a survey of the frequency of sensitization to aspergillus antigens was conducted in a group of asthmatics in cleveland and compared with a group of asthmatics in london, using common antigens for testing purposes. the two groups were comparable except for earlier onset, longer duration of asthma, and a larger number of males in the london group. twenty-eight per cent of the asthmatics from cleveland and 23% from london had immediate skin reactivity to aspergillus. seven and one-half percent from ... | 1978 | 350936 |
| [a case of allergic bronchopulmonary aspergillosis (author's transl)]. | | 1978 | 351105 |
| the nature of an initiator constitutive mutation in aspergillus nidulans. | | 1978 | 351427 |
| [one-stage bilateral pulmonary resection in a case of bilateral aspergilloma of the lung]. | | 1978 | 351582 |
| allergic bronchopulmonary aspergillosis. | allergic bronchopulmonary aspergillosis (abpa) is not a common condition, even though asthma due to sensitization to aspergillus antigen is very common in many countries because of the ubiquitous distribution of the fungus itself. during the course of 14 years, the mycology department of the v. p. chest institute, delhi, has confirmed the diagnosis of abpa in 46 patients. the present study is based on the follow-up of 17 patients for understanding the evolution of the disease. all of them had as ... | 1978 | 351756 |
| [genetic control of the sensitivity of aspergillus nidulans to mutagenic factors. vii. inheritance of cross-sensitivity to different mutagenic factors by uvs-mutants]. | to study the inheritance of the sensitivity to uv, x-rays, methylmethanesulphonate (mms), nitrosoguanidine (ng) and nitrous acid (na) in five uvs mutants of aspergillus nidulans, having multiple sensitivity to these factors, the sensitivity of recombinants obtained from crossing uvs mutants with uvs+ strain, resistant to all the factors analysed, and uvs leads to uvs+ revertants is investigated. four uvs mutants (15, 17, 19 and 26) are found to have a nomogenic control of sensitivity to differen ... | 1977 | 352800 |
| evaluating preservative efficacy by challenge testing during the development stage of pharmaceutical products. | | 1978 | 353021 |
| preparation of large molecular weight dna from the fungus aspergillus nidulans. | | 1978 | 353226 |
| cerebral aspergillosis following intracranial surgery. case report. | the authors report a case of cerebral aspergillosis. this is only the fifth case following intracranial surgery noted in the literature. pathogenesis, angiographic findings, and results of cerebrospinal fluid culture are discussed. | 1978 | 353230 |
| the role of precipitins in allergic lung disease. | | 1978 | 353417 |
| multiple independent control mechanisms affecting the acetamidase of aspergillus nidulans. | the acetamidase of aspergillus nidulans is induced by sources of acetyl coa, benzoate and benzamide and by beta-alanine and other omega-amino acids. the effects of these groups of inducers are appromimately additive. the cis-acting control site mutant, amdi9, affects induction by sources of acetyl-coa specifically. lesions in the amdr and gata genes affect induction by omega-amino acids specifically. mutations in the amda gene can lead to elevated acetamidase levels which still respond to the va ... | 1978 | 353500 |
| [isolation and purification of glucoamylase from the submerged culture of aspergillus foetidus atcc 14916]. | isolation and purification of glucoamylase from aspergillus foetidus atcc 14916 were examined. ethanol and ammonium sulphate proved to be the best precipitants. with their use the yield of glucoamylase was 99.0 and 92.3%, respectively. treatment of the culture liquid with 0.5% cacl2 and activated charcoal clarified the filtrate noticeably and left glucoamylase activity unchanged. during submerged cultivation the gungus synthesized no glucosyl transferase. a method to inactivate alpha-amylase thr ... | 1978 | 353788 |
| pumonary aspergillosis during hospital renovation. | during a 4-week period, aspergillus fumigatus caused disease in 2 patients and colonized a third patient in a renal transplant ward. our investigation indicated that increased exposure of these patients to spores probably occurred during renovation of the ward one floor above it. cases were significantly clustered (p = 0.014) during the period when work overhead caused dust to filter down through pores in the acoustical tiles of the false ceiling of the renal transplant ward. swab cultures demon ... | 1978 | 354445 |
| detection of mutagens produced by fungi with the salmonella typhimurium assay. | forty-one fungal isolates (one isolate per species) representing common plant pathogens and food crop contaminants were grown on sterile, polished rice and assayed for mutagenic activity in the salmonella typhimurium-microsome system. initially, single doses of aqueous and chloroform extracts of the moldy rice were assayed against the ta100 tester strain by incorporating extracts into the growth medium and by applying small quantities on disks placed on the agar surface. suspected activity was e ... | 1978 | 354528 |
| the use of fluorescein-labelled lectins in the detection and identification of fungi pathogenic for man: a preliminary study. | fluorescein-labelled lectins of known specificities for different sugars were used in an attempt to identify fungi in paraffin sections of surgical and post-mortem material. aspergillus fumigatus, blastomyces dermatitidis, candida albicans, cryptococcus neoformans, paracoccidioides brasiliensis and rhizopus oryzae have been studied with five fluorescein-labelled lectins and with basis of differences in their reactions with these stains. the results accord well with what is known of the chemistry ... | 1978 | 355633 |
| reduced expression of a distal gene of the prn gene cluster in deletion mutants of aspergillus nidulans: genetic evidence for a dicistronic messenger in an eukaryote. | the prn gene cluster involved in l-proline catabolism in aspergillus nidulans, has the gene order prna-prnd-regulatory region-prnb-prnc. prnb, prnd, and prnc specify proline permease, proline oxidase, and delta1-pyrroline-5-carboxylate (p5c) dehydrogenase, respectively. prna is probably a positive regulatory gene whose product is necessary for expression of the prn activities. proline induces proline permease and p5c dehydrogenase in prnd- mutants which lack proline oxidase, showing that proline ... | 1978 | 355839 |
| gaba transaminase provides an alternative route of beta-alanine synthesis in aspergillus nidulans. | three unlinked genes where mutation can lead to d(+)-pantothenic acid auxotrophy in aspergillus nidulans have been identified. pantoa is probably the structural gene for pantothenate synthetase (ec 6.3.2.1) whilst pantob and pantoc are involved in the syntheses of d-pantoic acid and beta-alanine, respectively. a pantoc- mutant is tentatively considered to be blocked in conversion of 5,6-dihydrouracil to beta-ureidopropionate. an alternative route of beta-alanine biosynthesis occurs by the transa ... | 1978 | 355840 |
| influence of viscosity of enzymatic reactions studied with glucoamylase of aspergillus niger. | viscosity can be interpreted in terms of transport of momentum and, therefore, it should influence the kinetics of enzyme reactions. a theory, developed by somogyi and damjanovich ((1975) j. theor. biol. 51, 393--401), is based on this idea. transport of momentum must always be accompanied by the transport of mass and this second influence of viscosity is a limiting factor for fast reactions in the liquid phase. a third aspect is, that the chemical potentials of the components of viscous solutio ... | 1978 | 356888 |
| aspergillosis of the maxillary sinus. | | 1978 | 357140 |
| distribution of autolysins in hyphae of aspergillus nidulans: evidence for a lipid-mediated attachment to hyphal walls. | preparations of broken aspergillus nidulans hyphae contained both free and wall-bound autolysins. the bound enzymes were not solubilized by 8 m licl or neutral or anionic detergents; they were readily detached from walls by a cationic detergent or by autodigestion. once detached, the enzymes did not reassociate with wall to give salt-resistant complexes. six enzymes hydrolyzing wall polymers were bound to the envelope, and the same activities were also detected among soluble proteins in the cyto ... | 1978 | 357422 |
| on the mechanisms of induced somatic recombination by certain fungicides in aspergillus nidulans. | four fungicides interfered with the segregation of chromosomes at mitosis of aspergillus nidulans by increasing the somatic recombination, shown as colour sectors in green colonies, in a strain heterozygous for spore colour mutations. in an attempt to discover the mechanisms by which these fungicides increased the somatic recombination, a prototrophic diploid strain, heterozygous for colour and several other appropriate markers in all chromosomes, was used which enabled the detection and classif ... | 1978 | 357961 |
| the role of aspergillus fumigatus fresenius in dermatitis of chickens. | aspergillus fumigatus proved to be the causative organism of dermatitis in chickens. this has been assessed mycologically as well as histopathologically. the histopathological lesions caused by the fungi are fully described. the different factors which might help the establishment of the mycotic infection are discussed. | 1978 | 357966 |
| mycotic mastitis in two cows. | | 1978 | 358027 |
| fumitoxins, new mycotoxins from aspergillus fumigatus fres. | extracts of cultures of aspergillus fumigatus isolated from silage were lethal to chicken embryos. using this test and thin-layer chromatography, four uv-absorbing toxins, designated as fumitoxins a, b, c and d, were isolated. analysis and mass spectrometry of crystallized fumitoxin a, the most abundant in the extract, established its molecular formula to be c31h42o8. infrared, uv spectroscopy, and chemical reactions suggested that fumitoxin a is a steroid. fumitoxins appear to be clearly differ ... | 1978 | 358921 |
| [determination of aspergillus fumigatus toxins by thin layer chromatography]. | | 1978 | 359584 |
| interaction of thiabendazole with fungal tubulin. | thiabendazole, 2-(4'-thiazolyl)benzimidazole, at 80 micrometer completely inhibits mitosis in hyphae of aspergillus nidulans, growing in liquid culture. dna and rna synthesis and mycelial growth are only partially inhibited at this concentration. binding studies with cell-free mycelial extracts from penicillium expansum showed that thiabendazole competitively inhibits [14c]carbendazim binding to tubulin, which suggests that the antimitotic activity of thiabendazole is based on interference with ... | 1978 | 361093 |
| a clinical environmental study of the aeroallergens of the islands of bermuda. | the major allergen responsible for allergic respiratory disease in the islands of bermuda has been shown to be derived from dermatophagoides pteronyssinus. 73% of the atopic group included in the survey gave weal and erythema reactions to extracts of this mite, whereas only 30% reacted to mixed pollen extracts and 10% to mould extracts. d. pteronyssinus was isolated from all house dust samples and it represented nature, with only a modest seasonal influence, and pollen counts were low throughout ... | 1978 | 361282 |
| fungal spores in lung and sputum. | a survey of fungal aerospora over a 2-year period was combined with an investigation of the fungi cultured from 295 samples of peripheral human lung and 2466 samples of sputum over the same period. 83% of lung and 88% of sputum samples contained culturable fungi, although in 16% of lung and 31% of sputum samples candida albicans was the only one. those fungi of small spore size tended to be found in lung tissue while those with larger spores were more likely to be found in the sputum. while thei ... | 1978 | 361283 |
| [a meningoencephalitic form of cerebral aspergillosis effectively treated with a derivative of berberine alkaloids (author's transl)]. | | 1978 | 361324 |
| pyridoxine and its relation to lipids. studies with pyridoxineless mutants of aspergillus nidulans. | the effect of pyridoxine deficiency on fat metabolism was studied using mutant strains of aspergillus nidulans requiring pyridoxine for growth. under pyridoxine deficiency the mutants exhibited increased levels of total lipid, sterols, phospholipids, and triacylglycerols. total fatty acids were found to decrease with pyridoxine deficiency. an increase in saturated fatty acids and decrease in unsaturated fatty acids were seen with deficiency. pyridoxine deficiency also increased lower carbon chai ... | 1978 | 361929 |
| reversion in variants from a duplication strain of aspergillus nidulans. | strains of aspergillus nidulans with a chromosome segment in duplicate, one in normal position and one translocated to another chromosome, are unstable at mitosis. in addition to variants which result from deletions in either of the duplicate segments, which usually have improved morphology, they produce variants with deteriorated morphology. three deteriorated variants reverted frequently to parental type morphology, both spontaneously and after ultra-violet treatment. of six reversions analyse ... | 1978 | 362154 |
| a mutation defective in the xanthine alternative pathway of aspergillus nidulans: its use to investigate the specificity of uay mediated induction. | in aspergillus nidulans uric acid can be produced from xanthine via purine hydroxylase i (xanthine dehydrogenase) or via the xanthine alternative pathway (darlington and scazzocchio, biochem. biophys. acta, 166, 569--571; 1968). a mutation defective in the xanthine alternative pathway of aspergillus nidulans is described. by combining this mutation with hxb-20 which results in complete loss of purine hydroxylase i and ii activities, but which conserves cross-reacting material, it is possible to ... | 1978 | 362158 |
| a quick method for testing recessive lethal damage with a diploid strain of aspergillus nidulans. | a simple method capable of detecting recessive lethal damage in a diploid strain of aspergillus nidulans is described. the method scores the recessive lethals on the 1st, the 3rd and the 5th chromosomes, which represent about 40% of the total map of a. nidulans. two examples of induced lethals, with ultraviolet irradiation and methyl methanesulfonate are shown. the frequency of lethals may reach 36% of the total population with uv irradiation. | 1978 | 362184 |
| [antifungal properties of paste used for local treatment of fungal lung diseases]. | | 1978 | 362381 |
| [studies on air pollution by fungal spores at selected working posts at a paper factory]. | | 1978 | 362382 |
| low repetitive dna content in aspergillus nidulans. | dna-dna reassociation experiments show that the genome of aspergillus nidulans consists of approximately 97 to 98 percent unique and 2 to 3 percent reiterated sequences. the reiterated dna sequences have a complexity of about 11,000 base pairs and are repeated approximately 60 times per haploid genome. ribosomal rna-dna hybridization experiments indicate that most of the repetitive dna codes for ribosomal rna. | 1978 | 362530 |
| a case of abortion in rabbit due to aspergillus fumigatus infection. | | 1978 | 362693 |
| [methodological approaches to the study of ultraviolet irradiation--induced dna degradation in mycelial fungi using the example of aspergillus nidulans]. | | 1978 | 363179 |
| identification of a gene for beta-tubulin in aspergillus nidulans. | | 1978 | 363278 |
| the genetic control of the molybdoflavoproteins in aspergillus nidulans. iv. a comparison between purine hydroxylase i and ii. | the purine hydroxylases i and ii of aspergillus nidulans [previously called xanthine dehydrogenases i and ii: scazzocchio, holl and foguelman, eur. j. biochem. 36, 428--445 (1973)] have been studied in crude extracts. the two enzymes differ in their substrate specificities, purine hydroxylase ii being able to accept nicotinate as a substrate and unable to hydroxylate xanthine. the kinetics of inhibition with allopurinol and oxypurinol are also different, the two analogues being pseudo-irreversib ... | 1978 | 363427 |
| a mutation in the xanthine dehydrogenase (purine hydroxylase i) of aspergillus nidulans resulting in altered specificity. implications for the geometry of the active site. | a point mutation in the structural gene for purine hydroxylase i (xanthine dehydrogenase) of aspergillus nidulans results in several dramatic pleiotropic effects. the mutant enzyme oxidises 2-hydroxypurine at position 6 rather than 8, shows a 70-fold reduction in the v for hypoxanthine, and loses the ability to accept xanthine as a substrate. allopurinol, a powerful pseudoirreversible inhibitor of the wild type enzyme, behaves as a good substrate of the mutant enzyme. we propose that the substra ... | 1978 | 363429 |
| [isolation and genetic study of aspergillus nidulans mutants defective in pyrimidine biosynthesis]. | 8 uridine-requiring pyr mutants were isolated from aspergillus nidulans under nitrosoguanidine treatment. all the mutants are capable to grow on the medium containing 20 mkg/ml of uridine or cytidine, or 100 mkg/ml of uracil, and they do not utilize thymidine, thymine, cytosine and deoxyuridine. their ability to grow in the presence of orotic acid demonstrates that the pyrimidine synthesis in all the mutants is blocked at stages preceding the conversion of orotic acid into orotidine monophosphat ... | 1978 | 363504 |
| a hydroxamic acid from aspergillus nidulans with antibiotic activity against proteus species. | an iron-complexing antibiotic with a narrow spectrum of biological activity was produced by several strains of aspergillus nidulans when grown in a low-iron, chemically defined medium. its chemical and biological properties closely resembled those of desferritriacetylfusigen, a metabolite of several other aspergilli and penicillia. | 1978 | 363670 |
| aspergillus infection in a patient receiving immunosuppressive drugs. | a rare case of an indolent aspergillus infection in a deep neck space in an immunologically compromised patient is reported. aggressive measures were taken to identify the cause of the infection. despite concerted antifungal therapy, the patient died. | 1978 | 363984 |
| invasion of a bronchial carcinoma by aspergillus fumigatus. | | 1978 | 364761 |
| [occurrence of aspergillus fumigatus in west berlin - contribution to the epidemiology of aspergillosis (author's transl)]. | the increasing incidence of human a. fumigatus infections particularly such of the respiratory tract has led to this study of the epidemiological situation. during the period between october 1968 and december 1977, a. fumigatus was isolated from clinical material in 425 cases. these findings which were established at the mycology unit, robert koch institute, federal health office, exhibited the following distribution by regions of the body or type of specimen: respiratory tract 277 (65.1(); veno ... | 1978 | 364887 |
| isolation of dna from aspergillus nidulans. | a procedure for isolation of dna from aspergillus nidulans on a preparative scale is described. mechanical disruption of lyophilized material in high-salt medium and treatment with proteinase k, followed by sedimentation of the lysate into saturated csc1 solution yielded pure, highly polymerized dna. | 1978 | 364902 |
| immunodiagnosis of systemic aspergillosis. i. antigenemia detected by radioimmunoassay in experimental infection. | because systemic aspergillosis is difficult to diagnose ante mortem, a study to improve immunodiagnosis was undertaken in a rabbit model of disseminated infection. we found that the predominant humoral response of infected animals was directed against four aspergillus antigens identified by crossed immunoelectrophoresis. one of these antigens, a cell-wall carbohydrate, was purified by gel-filtration chromatography and was used to develop a radioimmunoassay. the sensitivity of this assay was incr ... | 1979 | 366048 |
| some pulmonary manifestations of allergy. | | 1978 | 366356 |
| experimental mycosis in immunosuppressed rabbits. ii. acute and chronic aspergillosis. | the influence of immunosuppression on the course of experimental aspergillosis was investigated. rabbits (2.2--2.5 kg) were divided into four groups. group one received no drugs and was given 10(6) spores intravenously (iv) or intratracheally (it) on two occasions one week apart. weight gain or loss, appearance or disappearance of aspergillus antigen and/or antibody, and detection of aspergillosis at autopsy were followed. group 2 received weekly injections of cyclophosphamide (70 mg/kg) startin ... | 1978 | 366426 |
| [presence of sexual forms (cleistothecia and hülle cells) in a case of human maxillary sinus aspergillosis caused by aspergillus nidulans in association with aspergillus fumigatus]. | the authors observed, in a biopsic sample from a human maxillary sinus, the coexistence, in parasitic stages, of two different aspergillus species: a. fumigatus and a. nidulans. after having described the morphologies of each species, in sections on slides, and particularly those of cleistothecia and hülle-cells for the second, they draw attention to the three interests of such an observation: -- rarety of observing aspergillus nidulans in a parasitic stage, in spite of its particular thermotole ... | 1978 | 366429 |
| aspects of the molecular biology of lipoamide dehydrogenase. | | 1978 | 367117 |
| [treatment of severe forms of aspergillosis-related pneumonia]. | | 1978 | 368427 |
| an "up-promotor" mutation affecting the acetamidase of aspergillus nidulans. | a derivative of an area200 strain of aspergillus nidulans selected for strong growth on acetamide as the sole nitrogen source was found to have a mutation, amd-18, closely linked to amds, the acetamidase structural gene. this mutation results in 2--3 fold higher acetamidase activities than wildtype strains in uninduced as well as induced cultures. the effects of the amd-18 mutation are superimposed on the effects of other regulatory mutations affecting the acetamidase. the amd-18 mutation is cis ... | 1978 | 368568 |
| lactam utilisation in aspergillus nidulans: evidence for a fourth gene under the control of the integrator gene inta. | mutations in the lama gene of aspergillus nidulans prevent the conversion of exogenous 2-pyrrolidone (gamma-butyrolactam) to gamma-amino-n-butyrate (gaba) and also prevent the (probably analogous) utilisation of 2-piperidone (sigma-valerolactam). the lama gene, in linkage group viii, probably specifies a lactamase but a rôle in lactam uptake cannot be ruled out. lama is probably under the control of the positive acting regulatory gene inta, which can integrate its expression with the expression ... | 1978 | 368580 |
| [evaluation of nonlyophilized and lyophilized metabolic antigens of aspergillus fumigatus using the precipitation test]. | | 1979 | 368734 |
| [pathomorphological studies of spontaneous and experimental abortions in cows and guinea pigs]. | the morphologic studies of aspergillosis abortions in cows and guinea pigs were carried out on 83 spontaneously affected aborted cattle fetuses, pregnant guinea pigs and their offsprings. fifty-four fetuses were of spontaneously aborted cows from 12 farms along with 15 pregnant guinea pigs experimentally infected with aspergillus fumigatus and a total of 14 fetuses of theirs. microscopically, both in the cattle fetuses and in guinea pigs and their fetuses there were stasis, thrombosis, diapedeti ... | 1978 | 369113 |
| [progress in the therapy of systemic mycoses]. | | 1978 | 369201 |