| the status of safflower. | | 1966 | 5934266 |
| the composition of safflower seed. | | 1966 | 5934267 |
| safflower meal. | | 1966 | 5934268 |
| the role of safflower oil in edible oil applications. | | 1966 | 5934269 |
| high oleic acid safflower oil: a new stable edible oil. | | 1966 | 5938124 |
| a note on the anticholesterol activity of safflower oil. | | 1966 | 5942500 |
| desaturation of fatty acids in seeds of higher plants. | photosynthesizing flax, soybean, and safflower plants were exposed to (14)co(2) at seed-setting stage for a 1 hr period. seed was sampled periodically thereafter and the lipids were extracted. a triglyceride-rich fraction was methanolyzed; the resultant methyl esters were analyzed by gas-liquid chromatography and assayed for radioactivity. of the c(18) unsaturated acids, oleic was the first to acquire radioactivity, which subsequently and successively appeared in linoleic and linolenic acids. th ... | 1966 | 5949952 |
| influence of diet on the composition of plasma cholesterol esters in man. | the effect on the plasma cholesterol esters of diets rich in either carbohydrate, chocolate, or safflower oil was studied sequentially in two men. the changes in the cholesterol esters of the major plasma lipoproteins were studied by measuring (a) the distribution of fatty acids in the esters and (b) the distribution of radioactivity among the esters after the administration of cholesterol-4-(14)c labeled lipoproteins. similar changes were found in the cholesterol esters of the two major lipopro ... | 1966 | 5965292 |
| a radioautographic study of glyceride synthesis in vivo during intestinal absorption of fats and labeled glucose. | radioautography was used to detect the synthesis of labeled glycerides in intestinal absorptive cells following injections of fatty chyme and glucose-6-h(3) into ligated segments of upper jejunum of fasting rats. absorption intervals ranged from 2 to 20 min. labeling is evident throughout the cells in as short a time as 2 min. most grains are present over droplets of absorbed fat beginning with those in the endoplasmic reticulum immediately subjacent to the terminal web. with longer absorption p ... | 1966 | 5971642 |
| dietary fat and cholesterol and serum cholesterol in the gerbil. | groups of gerbils were fed purified diets containing either 10 or 20% of safflower, olive, or coconut oil. each diet was fed without cholesterol and with 0.1 and 0.2% of added cholesterol. the animals were bled after 2, 4, and 8 wk for the determination of the level of serum cholesterol. the major factors affecting the level of serum cholesterol were the kind of dietary oil, the amount of dietary cholesterol, and the length of time the diet was fed. the level of safflower oil had a statistically ... | 1967 | 6038560 |
| high-oleic safflower oil. stability and chemical modification. | | 1967 | 6041386 |
| effects of dietary safflower oil or hydrogenated coconut oil on growth rate and on some blood and tissue components of pigs fed a fat-free diet. | | 1967 | 6053737 |
| fatty acid changes in liver and plasma lipid fractions after safflower oil was fed to rats deficient in essential fatty acids. | 1. fatty acid patterns of liver and plasma triglycerides, phospholipids and cholesteryl esters were determined at intervals during 24hr. after essential fatty acid-deficient rats were given one feeding of linoleate (as safflower oil). 2. liver triglyceride, phospholipid and cholesteryl ester fatty acid compositions did not change up to 7hr. after feeding. between 7 and 10hr., linoleic acid began to increase in all fractions, but arachidonic acid did not begin to rise in the phospholipid until 14 ... | 1967 | 6056631 |
| effect on serum cholesterol of the rat, of feeding pig depot fat after the ingestion of safflower oil. | | 1967 | 6063224 |
| suppression of rat liver fatty acid synthesis by eicosa-5,8,11,14-tetraynoic acid without a reduction in lipogenic enzymes. | in meal-fed rats supplementation of safflower oil (5 g per 100 g diet) to a fat-free basal diet resulted in the characteristic suppression of liver fatty acid synthetase and acetyl-coa carboxylase activities, which was accompanied by a 60% decrease in the rate of hepatic fatty acid synthesis. the decline in activity of these lipogenic enzymes was completely prevented by adding 0.05% eicosa-5,8,11,14-tetraynoic acid (tya) to the safflower oil diet. fatty acid analysis of the livers indicated that ... | 1982 | 6123562 |
| acyl group composition of lipids and the activities of (na+ + k+)-atpase, 5'-nucleotidase and gamma-glutamyltranspeptidase in salivary glands and kidneys of rats fed diets containing different dietary fats. | two nutritional models, an essential fatty acid deficiency model and the feeding of saturated versus unsaturated fats, were used in a feeding study in order to assess the relationship between tissue fatty acid composition and the activities of some membrane-associated enzymes. purified diets containing 7% hydrogenated coconut oil, 7% corn oil, 10% safflower oil or butter were fed to rats for a total of 49 weeks (1 week of pregnancy, 3 weeks of lactation and 45 weeks post-weaning). tissue homogen ... | 1983 | 6134556 |
| resistance of lung fatty acid synthesis to inhibition by dietary fat in the meal-fed rat. | one-half of the palmitate utilized by the lung for production of the surfactant phospholipid, dipalmitoyl phosphatidylcholine, originates from de novo palmitate synthesis in the lung. in this report the lung was examined for the influence of dietary fat on the lung de novo fatty acid synthesis pathway. lung lipogenesis was reduced by fasting and accelerated by carbohydrate refeeding or insulin injection. however, in general lung fatty acid synthesis was unaffected by dietary fat. supplementing o ... | 1984 | 6142100 |
| effects of the type of dietary fat at two levels of vitamin e in wistar male rats during development and aging. iii. biochemical and morphometric parameters of the liver. | the purpose of this study was to explore in rats the possible influence of the type of dietary fat at two extreme levels of vitamin e on several biochemically determined hepatic changes and on a number of quantitatively analyzed structural and ultrastructural variations with age in hepatic cells. six groups of weanling wistar male rats were fed ad libitum isoenergetic diets containing similar amounts (15 g per 100 g diet) of saturated fat (coconut oil), unsaturated fat (safflower oil) or a combi ... | 1981 | 6166818 |
| detection of lewis a antigenic determinants in chinese medicinal herbs. | two chinese medicinal herbs, leonurus sibiricus l. and carthamus tinctorius l., were found to have high levels of lewis a (lea)-like determinants. the water-soluble extracts specifically inhibited hemagglutination, hemolysis, and lymphocyte cytotoxicity directed against lea. they did not inhibit leb nor other specificities detected on lymphocytes, resulting from the interaction of lewis, secretor, and abo systems such as a1leb and a1led. the activity was nondialyzable, resistant to boiling and p ... | 1983 | 6195819 |
| [effect of carthamus tinctorius co. injection on the changes in blood rheology after surgery]. | | 1984 | 6237793 |
| [pharmacological studies of a chinese medicinal herb--carthamus tinctorius]. | | 1984 | 6241541 |
| fat induced hypertension in rabbits. effects of dietary fibre on blood pressure and blood lipid concentration. | rabbits were fed diets containing 200 g.kg-1 coconut oil, palm oil, or safflower oil. some of the diets also contained 200 g.kg-1 cellulose. the blood pressure was measured daily by a non-invasive technique for the 2 month duration of the experiment. blood samples were drawn after an overnight fast at intervals during the experiment and analysed for lipids. blood pressure was always increased by a fat-enriched diet. this effect was diminished and delayed by adding cellulose to the diets, though ... | 1980 | 6253068 |
| [protective effect of alpha-linolenic acid in encephalomalacia in chickens]. | encephalomacia is a vitamin e deficiency syndrome which affects the cerebellum of young chicks. the lesion includes degenerative alterations of cellular and fibrillar elements, apparently as the result of the ischaemia caused by thrombotic events in the microvascular system. a supply of linoleic acid, as fatty acid methyl esters prepared from safflower oil (carthamus tinctorius), caused a high incidence of encephalomalacia. on the other hand, linseed oil esters, rich in alpha-linolenic acid, did ... | 1980 | 6254420 |
| effects of dietary long-chain fatty acids on the rat biosynthesis of unsaturated fatty acids in the rat. | menhaden oil (me) was included in semisynthetic diets to study the effect of long-chain fatty acids, mainly 20:5n3 and 22:6n3, on the biosynthesis of polyunsaturated fatty acids and on the 6- and 9-desaturase activities in liver microsomes. five experimental diets, with the following fat supplements, were fed to male rats from weaning for a period of 33 weeks: 5% safflower oil (saf) + 10% hydrogenated coconut oil (hco), 5% saf + 5% hco + 5% me, 5% saf + 10% me, 15% hco and 5% hco + 10% me. the l ... | 1982 | 6279803 |
| the influence of linoleic acid intake on the kinetics of adenine nucleotide translocase. | dietary enrichment of mitochondrial polyenoic fatty acid content was associated with increased respiratory activity (abuirmeileh and elson). the influence of the membrane lipid composition on the adenine nucleotide translocase (adnt) was studied in rats that were fed diets formulated with beef tallow (bt) to provide low or safflower oil (so) to provide high contents of linoleic acid. the phosphatidylcholine/phosphatidylethanolamine ratio was 40% higher in the so mitochondria due primarily to an ... | 1983 | 6302433 |
| pituitary content of gonadotropins and receptors for gonadotropin-releasing hormone (gnrh) and hypothalamic content of gnrh during the periovulatory period of the ewe. | studies were undertaken to determine if the number of hypophyseal receptors for gnrh changes at the time of the preovulatory surge of lh in ewes. concentrations of lh, fsh, progesterone, and estradiol in serum and concentrations of lh and fsh in pituitary were measured. the content of gnrh in the hypothalamus was also determined. estrus was synchronized in 35 cross-bred ewes by injecting prostaglandin f2 alpha (pgf2 alpha) at 0 and 4 h (7.5 mg each, im) on day 14 of a naturally occurring estrous ... | 1984 | 6317346 |
| acyl group distributions in tissue lipids of rats fed evening primrose oil (gamma -linolenic plus linoleic acid) or soybean oil (alpha-linolenic plus linoleic acid). | three groups of rats were fed diets with either 10 weight percent (wt%) of evening primrose oil, safflower oil or soybean oil for 11 weeks. diets contained 7.1 wt% linoleic acid + 0.8 wt% gamma-linolenic acid, 7.6 wt% linoleic acid, or 5.3 wt% linoleic acid + 0.7 wt% alpha-linolenic acid, respectively. in liver mitochondria as well as in heart, dietary gamma-linolenic acid did not affect the fatty acid profiles of phosphatidylcholines (pc), phosphatidylethanolamines (pe) or cardiolipins (cl), wh ... | 1983 | 6318009 |
| the influence of dietary isomeric and saturated fatty acids on atherosclerosis and eicosanoid synthesis in swine. | weanling swine were fed for 6 months high fat diets containing as fat source, a high oleic acid safflower oil, lard, or a partially hydrogenated soybean oil blended with soybean oil. the extent of atherosclerosis in left coronary arteries and the ability of vascular components to synthesize eicosanoids important for blood clotting were determined. there was no significant difference (p greater than 0.05) in the extent of atherosclerosis or the synthesis of thromboxane a2. significant effects wer ... | 1984 | 6364773 |
| a novel, general radioimmunoassay for acyl carrier proteins. | a radioimmunoassay (ria) for acyl carrier proteins (acp) is described that is based on the competitive binding between [3h]acyl-acp and unlabeled acp of the same species. the radiolabeled antigen, [3h]palmitoyl-acp, is enzymatically synthesized by escherichia coli acyl-acp synthetase. because acyl-acp synthetase can specifically radiolabel acp in crude extracts from several plant sources, the use of this enzyme to prepare [3h]acyl-acp obviates the need for pure preparations of each acp. preparat ... | 1984 | 6372545 |
| microbial growth comparisons of five commercial parenteral lipid emulsions. | the ability of parenteral lipid emulsions to support microbial growth was compared using commercially available brands of lipid emulsion. both 10 and 20% concentrations of soybean and safflower oil emulsions were used. washed cultures of six gram-negative, three gram-positive, and one yeast, in concentrations of 1 x 10(4) to 2 x 10(4) colony-forming units/ml, were inoculated into lipid emulsion aliquots and stored at room temperature. there were than subcultured at 0, 6, 12, 24 and 48 hr. after ... | 1984 | 6379217 |
| an inhibitory effect of dietary polyunsaturated fatty acids on renin secretion in the isolated perfused rat kidney. | the influence of dietary modification of polyunsaturated fatty acids (pufa) on renin secretion, renal vascular tone and prostanoid excretion was studied in isolated perfused rat kidneys under basal conditions and in response to angiotensin ii. after a four-week regimen of diets enriched with safflower oil, linseed oil or saturated fat, providing 20% of total energy intake (20 energy %), the animals which were fed linseed oil showed a significant fall in the proportion of arachidonic acid in rena ... | 1984 | 6397528 |
| the effect of ten and twenty per cent safflower oil emulsion given as thirty to fifty per cent of total calories. | in a prospective study of seven patients undergoing operations, 10 and 20 per cent safflower oil emulsions were found to be safe and effective as a major component of adult parenteral nutrition. specifically, clinically important adverse effects of the emulsions as monitored by clinical evaluation and screening hematologic and blood chemistry determinations were not identified. further, an extensive coagulation profile in these patients has failed to identify procoagulant effects of parenteral s ... | 1983 | 6403994 |
| testosterone administration to mares during estrus: duration of estrus and diestrus and concentrations of lh and fsh in plasma. | to study the possible role of ovarian androgens in regulation of follicle stimulating hormone (fsh) secretion in the cycling mare, five mature, intact mares were treated with testosterone (20 micrograms/kg of body weight) daily during estrus; five control mares received safflower oil on the same schedule. mares were teased for estrus and samples of jugular blood were drawn daily through one full estrous cycle. concentrations of fsh in plasma were measured by a newly developed radioimmunoassay ba ... | 1983 | 6406417 |
| comparative study of clearance of 10% and 20% fat emulsion. | the rate of fat emulsion clearance from the blood of 10 healthy adult male volunteers administered 0.1 gram of fat per kilogram body weight as 10% or 20% safflower oil emulsion (liposyn) was studied. the subjects were hospitalized for 2 days and each was given the predetermined amount of one of the two fat emulsions (10% or 20%) by rapid injection into a peripheral vein and the rate of clearance of the emulsion determined over a 60-minute period, beginning when half of the emulsion had been inje ... | 1983 | 6406698 |
| role of linoleate as an essential fatty acid for the cat independent of arachidonate synthesis. | to determine the essential fatty acid (efa) requirements of the cat, specific pathogen-free kittens were fed either a linoleate-deficient diet or one of two diets containing 5% safflower seed oil (sso) with or without 0.2% tuna oil. the diets were fed for 82-101 weeks beginning at 3 months of age. the results showed that linoleate is an essential fatty acid for the cat. linoleate deficiency resulted in reduced feed efficiency (in males), high rates of transepidermal water loss, poor skin and coa ... | 1983 | 6408230 |
| the effect of intravenous safflower oil emulsion on the clotting mechanism. | a new fat emulsion for intravenous use, derived from safflower oil (abbott laboratories), was studied. the clotting mechanism was compared with a battery of tests performed during the infusion of total parenteral nutrition (tpn) using glucose alone and during infusion of tpn using both glucose and fat. five adult surgical patients underwent tpn with 7.0 per cent amino acid solution for ten days, receiving glucose as their only nonprotein calorie source on days one, two, nine, and ten (40 kcal/kg ... | 1983 | 6412610 |
| effects of intravenously administered safflower oil emulsion on respiratory gas exchange of low-birth-weight infants. | safflower oil emulsion (liposyn 10%) was infused intravenously to supplement energy intake in five low-birth-weight infants. respiratory gas exchange was measured before and after the addition of fat emulsion in doses of 1-2 g of fat/kg/day to an intravenous feeding regimen of dextrose and amino acids. the oxygen consumption and carbon dioxide production rates were greater during fat infusion in all infants, but the mean respiratory quotient was not different. the increase in energy intake provi ... | 1983 | 6413670 |
| microbial growth patterns in intravenous fat emulsions. | microbial growth patterns were studied in intravenous fat emulsions under conditions that simulated touch contamination before or during administration. commercially available emulsions of 10% and 20% soybean oil and 10% safflower oil in 500-ml bottles were inoculated with two concentrations of each of four organisms: a coagulase-negative staphylococcus isolated from a venipuncture site, escherichia coli, pseudomonas aeruginosa, and candida albicans. the bottles were kept at room temperature, an ... | 1983 | 6416063 |
| effects of testosterone, dihydrotestosterone and estradiol on gonadotropin release after gonadotropin releasing hormone administration in cyclic mares. | sixteen intact cyclic mares were treated on the fourth day of estrus and then every other day for a total of six injections with 1) testosterone propionate, 2) dihydrotestosterone (dht) benzoate, 3) estradiol (e2) benzoate or 4) safflower oil. mares were given gonadotropin releasing hormone (gnrh) on day 3 of estrus (pretreatment) and again 24 h after the last steroid or oil injection. treatment with testosterone propionate resulted in a greater (p less than 0.05) follicle-stimulating hormone (f ... | 1983 | 6416322 |
| e-rosette formation, total t-cells, and lymphocyte transformation in infants receiving intravenous safflower oil emulsion. | there has been much concern about impaired immune function in children receiving infused lipid emulsions. immunologic studies were carried out on 15 infants maintained on parenteral nutrition with intravenous safflower oil emulsion as part of the infusate. significant increases in percentage rosette formation, total circulating t-cells, and mitogenesis to phytohemagglutinin and pokeweed mitogen were demonstrated after only 1 wk of lipid infusion. additional parenteral nutrition did not further i ... | 1983 | 6418909 |
| studies of the absorption and enterohepatic circulation of 7,12-dimethylbenz[a]anthracene in the rat. | this study was undertaken to examine intraluminal factors which might alter the bioavailability of an orally ingested hydrocarbon carcinogen, 7,12-dimethylbenz[a]anthracene, and to assess the extent of its enterohepatic circulation. rats with biliary and duodenal fistulae were administered radiolabelled hydrocarbon dissolved in olive oil, safflower oil, or medium-chain triglyceride only or with exogenous bile. subsequent biliary excretion and plasma levels of radiolabel were monitored. luminal b ... | 1983 | 6420027 |
| ventilatory drive in normal man during semistarvation. | the effects of reduced caloric intake on ventilatory drive were investigated in normal volunteers. during a ten-day semistarvation period, six subjects (group 1) received parenterally an amino acid solution providing 550 kcal/d sufficient to prevent a negative nitrogen balance. six subjects (group 2) received in addition a safflower oil solution providing a total caloric intake of 1,100 kcal/d. hypoxic ventilatory drive was estimated by an index (parameter a) of the relation between minute venti ... | 1984 | 6420117 |
| protein dynamics during refeeding of protein-depleted rats: effects of increasing amino acid intake by tpn or enteral continuous feeding. | the effect of increasing nitrogen intake with constant calorie supply was studied in protein-depleted rats. animals were randomized into three paired groups to receive either total parenteral nutrition (tpn) or enteral (ef) isocaloric feedings (240 kcal x kg-1 x day-1) differing only in their amount of amino acids. the diets, composed of dextrose, a safflower oil emulsion and crystalline amino acids, were infused continuously for 5 days. daily nitrogen intakes were for controls (ef, n = 7; tpn, ... | 1984 | 6420525 |
| protein metabolism during total parenteral nutrition (tpn) in injured rats using medium-chain triglycerides. | there are metabolic limitations to the infusion of large quantities of dextrose in critically ill patients receiving total parenteral nutrition. of the alternative, nonprotein lipid sources, medium chain triglycerides (carbon chain length 8 and 10) are more rapidly oxidized and are deposited in the adipose tissue at rates much less than long chain triglycerides. in rats with burn injury receiving hypocaloric (dextrose and amino acids) parenteral feeding, we studied the changes in protein metabol ... | 1984 | 6434897 |
| structured medium-chain and long-chain triglyceride emulsions are superior to physical mixtures in sparing body protein in the burned rat. | the present study was undertaken to compare the effectiveness of a physical mixture of long-chain and medium-chain triglycerides with an emulsion consisting of chemically synthesized triglycerides composed of medium-chain and long-chain fatty acids in similar proportions. sprague-dawley rats received a 25% body surface area full-thickness scald burn on the dorsum. for the next three days, all rats received 300 kcal/kg/day as 160 kcal/kg/day glucose, 50 kcal/kg/day amino acid, and an additional 9 ... | 1984 | 6434898 |
| prevention of glomerulonephritis and prolonged survival in new zealand black/new zealand white f1 hybrid mice fed an essential fatty acid-deficient diet. | female b/w mice spontaneously develop an autoimmune disease that is similar to systemic lupus erythematosus. antibodies to doublestranded dna (dsdna) and antinuclear antibodies develop in aging animals; death from immune complex-mediated glomerulonephritis occurs from 8 to 12 mo of age. it has been reported that prostaglandin (pg)e(1) treatment of such mice prolongs survival. in the present study, four groups of female b/w mice were studied beginning at 6-11 wk of age on the following regimens: ... | 1981 | 6450777 |
| [effects of carthamus tinctorius l. and angelica sinensis (oliv.) diels on experimental myocardial ischemia]. | | 1981 | 6459874 |
| sn-glycerol-3-phosphate acyltransferase in a particulate fraction from maturing safflower seeds. | the properties of the acyl-coa:sn-glycerol-3-phosphate o-acyltransferase in a 20,000g particulate fraction from maturing safflower seeds were investigated. the optimum ph of the reaction was 7.2. the apparent km for glycerophosphate was 0.54 mm. only monoacylglycerophosphate was accumulated in the particulate fraction under normal conditions. position 1 of glycerophosphate was exclusively esterified with either palmitoyl-coa or linoleoyl-coa as acyl donor, while 2-acylglycerophosphate was the mi ... | 1984 | 6465892 |
| the effect of the saturation and isomerization of dietary fatty acids on the osmotic fragility and water diffusional permeability of rat erythrocytes. | weanling rats were fed semi-purified diets containing 15% by weight of either corn oil, a high oleic acid safflower oil, lard or hydrogenated soybean oil. significant changes in the fatty acid composition of erythrocytes were induced by these dietary fats. the compositional changes did not effect water diffusional permeability, but did affect their osmotic fragility. an increased fragility appeared to be associated with an increased octadecenoate content of the membranes. | 1984 | 6466669 |
| the effect of dietary fat saturation on plasma and hepatic lipoproteins in the rat. | semipurified diets containing 10% kilocalories from either safflower oil (so), corn oil (co), olive oil (oo) or palm oil (po) were fed to weanling male rats for 2 weeks. the effects of dietary fat saturation on plasma lipids and lipoproteins were: 1) nonfasted plasma cholesterol concentration was higher in rats fed oo (mean +/- sem = 81.0 +/- 2.9 mg/dl) vs. co (67.5 +/- 2.9); 2) plasma chylomicron cholesterol concentration was higher in rats fed oo vs. so and co, with po values in between; and 3 ... | 1984 | 6470824 |
| effect of dietary fat on lipid secretion and ketone body production in rat liver. | perfused livers from rats fed different fats were used to examine the effect of dietary fat on the rat of hepatic lipoprotein synthesis and fatty acid metabolism. dietary fats (10% level) used were safflower oil (18:2), camellia oil (18:1) and tristearin (18:0). the results were compared with those obtained from rats fed on a low-fat diet (1% safflower oil). when no oleate substrate was infused, triglyceride secretion rates were approximately the same among the different fat groups. infusion of ... | 1984 | 6470833 |
| the effect of hypolipidemic drugs on plant lipid metabolism. | the effect of hypolipidemic drugs, wy14643 and dh990, on plant lipid metabolism has been studied. the total incorporation of [14c]acetate into lipids was inhibited by addition of both drugs to aged potato (solanum tuberosum) tuber discs, spinach (spinacia oleracea) leaves, and spinach chloroplasts, while the incorporation in chlorella vulgaris cells was affected only by dh990. moreover, dh990 inhibited the incorporation of 14c-labeled fatty acids into phosphatidylcholine and phosphatidylethanola ... | 1984 | 6486826 |
| evidence for the reversibility of the acyl-coa:lysophosphatidylcholine acyltransferase in microsomal preparations from developing safflower (carthamus tinctorius l.) cotyledons and rat liver. | acyl exchange between acyl-coa and position 2 of sn-phosphatidylcholine occurs in the microsomal preparations of developing safflower cotyledons. evidence is presented to show that the acyl exchange is catalysed by the combined back and forward reactions of an acyl-coa:lysophosphatidylcholine acyltransferase (ec 2.3.1.23). the back reaction of the enzyme was demonstrated by the stimulation of the acyl exchange with free coa and by the observation that the added coa was acylated with acyl groups ... | 1984 | 6497849 |
| the effects of dietary cholesterol on blood and liver polyunsaturated fatty acids and on plasma cholesterol in rats fed various types of fatty acid diet. | male rats were fed on a fat-free diet for 8 weeks and then switched to diets containing 10% hydrogenated coconut oil (hco), safflower oil (sfo) or evening primrose oil (epo). half of each group was also given 1% of cholesterol in the diet. after 5 further weeks, plasma, red cell and liver fatty acids were measured in the various lipid fractions. plasma and liver cholesterol also were estimated. in almost all fractions and on all three diets, feeding cholesterol led to accumulation of the substra ... | 1984 | 6503628 |
| the effects of essential fatty acid deficiency on pulmonary alveolar macrophage function. | male rats were maintained for periods of up to 16 weeks on a fat free diet which was supplemented with either 4% tripalmitin (essential fatty acid [efa] deficient) or with 4% safflower oil (saff, control). pulmonary alveolar macrophages (pam) were obtained by lung lavage. pam from efa deficient rats had reduced phagocytic activity and capacity. intracellular killing of ingested yeast was also reduced by efa deficiency. the activity of acid phosphatase, beta-glucuronidase and cathepsin d from pam ... | 1985 | 6537682 |
| induction and suppression of phytoalexin biosynthesis in cultured cells of safflower, carthamus tinctorius l., by metabolites of alternaria carthami chowdhury. | cell suspension cultures derived from the safflower variety us-10 respond to treatment with cell wall elicitors from either phytophthora megasperma f.sp.glycinea or alternaria carthami chowdhury by producing polyacetylenic phytoalexins. these polyacetylenes were absent from the uninduced cell cultures. low concentrations of brefeldin a, a toxin produced by a. carthami, when added to suspension-cultured safflower cells, considerably diminished the accumulation of the phytoalexins following elicit ... | 1984 | 6538399 |
| [effect of safflower on cerebral ischemic edema--a study in the gerbil stroke model]. | | 1984 | 6543727 |
| dietary fat and cecal microbial activity in the rat. | weanling rats were fed low-fat (1% w/w safflower oil) or high-fat (1% w/w safflower oil plus 35% w/w beef fat or cocoa butter) diets for 30 days, and the activities of five cecal microbial enzymes were determined. when compared with the low-fat diet, beef fat significantly increased total cecal beta-glucuronidase activity, but cocoa butter, with a similar fatty acid composition, did not. both high-fat diets significantly decreased total cecal azoreductase, beta-glucosidase, and nitrate reductase ... | 1984 | 6545572 |
| lung surfactant and fatty acid composition of lung tissue and lavage of rats fed diets containing different lipids. | two nutritional models, essential fatty acid (efa) deficiency and the feeding of saturated vs unsaturated fats, were used to determine the effects of dietary lipids on the fatty acid composition of rat lung and lavage. semipurified diets containing 7% corn oil, 7% hydrogenated coconut oil (efa-deficient), 10% butter or 10% safflower oil were fed to dams during lactation and thereafter to their offspring for a total of 24 weeks. lipids were extracted from the lung lavage and lung tissue and their ... | 1984 | 6546777 |
| dietary modification of fatty acid and prostaglandin synthesis in the rat. effect of variations in the level of dietary fat. | dietary supplements with safflower oil, linseed oil, cod liver oil and hydrogenated coconut oil were given to rats at levels of 5, 20 and 40 energy % to simultaneously assess the effects of both type and level of dietary fat on tissue fatty acid composition and prostanoid synthesis. there was no significant change in weight gain or blood pressure between the dietary groups after the 4-week dietary regimen. the liver oil and linseed oil diets depressed the arachidonic acid content of kidney phosp ... | 1984 | 6548159 |
| tumor promotion by dietary fat in azoxymethane-induced colon carcinogenesis in female f344 rats: influence of amount and source of dietary fat. | the promoting effect of dietary corn oil (co), safflower oil (so), olive oil (oo), coconut oil (cc), and medium-chain triglycerides (mct) on azoxymethane (aom)-induced colon tumors was studied in female f344 rats. the animals were fed low-fat diets containing 5% co, 5% so, or 5% oo 2 weeks before, during, and 1 week after sc injection of 20 mg aom/kg body weight. one week after the aom treatment, groups of animals were transferred to high-fat diets containing 23.52% co, 23.52% so, 23.52% oo, and ... | 1984 | 6583457 |
| effect of dietary triglycerides on lymphocyte transformation in rats. | weanling rats were fed casein-based diets containing purified and mixed triglycerides to evaluate the effect of these lipids on mitogen-induced lymphocyte transformation, lymphoid organ weights, and fatty acid profiles of the total lipid in plasma, spleen, and thymus. test lipids were added at a level of 8 g per 100 g of diet. all diets contained 0.82 g of safflower oil per 100 g. the digestibility coefficients for tristearin, tripalmitin, and trimyristin were 20, 37, and 85%, respectively. dige ... | 1983 | 6600786 |
| cultural control of the root nematodes pratylenchus indicus in rice through crop rotations. | pratylenchus indicus nematodes cause damage to the roots of rice plants, which may lead to considerable yield reductions. in field trials with six different rice-based rotations it was tested whether the inclusion of other crops into the rotation can influence the population of pratylenchus indicus. investigation of soil samples and roots showed that rice, safflower, and tobacco increased the nematodes, whereas fallowing or growing phaseolus radiatus l. decreased them. | 1983 | 6626134 |
| acute toxicity of some silver salts of sulfonamides in mice and the efficacy of penicillamine in silver. | the silver salt of 2-metanilamido-5-chloropyrimidine (agmcp) and the sodium, amminosilver and trimethylphosphite-silver salts of 3',5'-dichlorobenzenesulfonanilide (nadbs, agnh3dbs and agp(och3)3dbs were synthesized as possible antibiotic of antiparasitic drugs. all the organosilver compounds were extremely water-insoluble. for animal studies these, and other reference compounds, were given as fine suspensions in an emulphor-safflower oil mixture. the ip ld50's in mice in mmol/kg were: 1.67 for ... | 1983 | 6628259 |
| hepatic fatty acids and acyl desaturases in rats: effects of dietary carbohydrate and essential fatty acids. | for a 9-week period, six groups of weanling male rats were fed either a fat-free diet or a diet containing 10% hydrogenated coconut oil (hco) or 10% safflower oil (saf), respectively. each of these diets contained either glucose or sucrose as the only carbohydrate. in the fat-free diets, the carbohydrate level was 67.3% and in the fat-supplemented diets 44.8%. including hco in the fat-free diet did not significantly alter hepatic 5-, 6-, and 9-desaturase activity, whereas addition of saf signifi ... | 1983 | 6631540 |
| cerebral infarction improved by safflower treatment. | the effect of safflower on cerebral infarction was studied in 152 mongolian gerbils. sixty-three animals were evaluated neurological deficit over 8 hours postoperation, then sacrificed and ne, da and 5-ht contents of each cerebral hemisphere and brain stem were determined. ne, da and 5-ht of hemisphere ipsilateral to the ligated artery in untreated animals declined significantly compared with sham-operated animals and safflower-treated gerbils. there was no significant difference between safflow ... | 1983 | 6660215 |
| bacterial and fungal growth in intravenous fat emulsions. | growth of bacterial and fungal organisms in i.v. fat emulsions was studied. a total of 81 isolates of 15 bacterial and fungal strains were used to inoculate (in test tubes) 10% soybean oil emulsion (intralipid, cutter laboratories), 10% safflower oil emulsion (liposyn, abbott laboratories), trypticase soya broth, and 0.9% sodium chloride at about 2500 organisms/ml. duplicate samples and negative controls were prepared. samples were handled under two procedures after inoculation: (1) initially re ... | 1983 | 6660230 |
| regulation of cholesterol synthesis in jejunal absorptive cells of the rat. | cholesterol metabolism was studied in jejunal mucosa of the rat with special emphasis on cholesterol synthesis of villous cells, the site of intestinal lipid absorption. the type of diet and nutritional state clearly affected the cholesterologenesis of villous cells. consequently, the incorporation of 14c-acetate into nonsaponifiable lipids (nsl; includes squalene and sterols) decreased in the following order of magnitude: 1) fat-free diet supplemented with safflower oil (ffd-so), 2) ffd alone, ... | 1983 | 6673071 |
| effect of high fat and iron levels on the growth and mortality of chickens. | four experiments were conducted with chicks to determine whether the heating of vegetable oil and its contamination with iron might have detrimental effects upon its use in chicken diets. soybean oil and safflower oil heated at 230 c for 51 hr and linseed oil heated at 240 c for 24 hr gave reduced growth when fed to chickens at 20 percent of the diet. heating soybean oil at 175 c for 51 hr had no detrimental effect. however, iron at 5000 ppm depressed growth significantly when fed in a low fat d ... | 1983 | 6681900 |
| triglyceride and fatty acid clearance in neonates following safflower oil emulsion infusion. | fifteen neonates requiring parenteral nutrition with lipid emulsion were given a 1.0 g/kg dose of safflower oil emulsion to evaluate triglyceride (tgy) and free fatty acid clearance. the dose was infused intravenously over 4 hr, and serum was obtained at 0, 2, 4, 6, and 8 hr. peak serum tgy averaged 592 mg/dl for the appropriate for gestational age newborns and 606 mg/dl for the small for gestational age babies. the small for gestational age neonates had significantly higher serum free fatty aci ... | 1983 | 6683332 |
| hypertriglyceridemia during the intravenous infusion of a safflower oil-based fat emulsion. | | 1983 | 6685759 |
| the effect of hypolipidemic drugs wy14643 and dh990, and lysophospholipids on the metabolism of oleate in plants. | the effects of the addition of hypolipidemic drugs and 1-acylglycerolipids on the metabolism of oleate in plants have been studied in vivo and in vitro. using aged potato slices with [14c]oleate as a precursor, it was found that these drugs markedly inhibited both the incorporation into complex lipids and the desaturation of oleate to linoleate. moreover, in vitro experiments, carried out with microsomes prepared from developing safflower seeds and [14c]oleate or [14c]oleoyl-coa as precursors, c ... | 1984 | 6696430 |
| the adaptive effects of dietary fish and safflower oil on lipid and lipoprotein metabolism in perfused rat liver. | to elucidate the mechanisms underlying the plasma triacylglycerol-lowering effects of certain fish oils, livers from male rats fed either a standard commercial diet (controls) or diets supplemented with 15% (w/w) fish or safflower oils were perfused with undiluted rat blood. rates of hepatic lipogenesis, measured by the incorporation of 3h2o into fatty acids, followed the order: control greater than safflower oil greater than fish oil. secretion of newly synthesized fatty acids in very-low-densi ... | 1984 | 6696922 |
| the saturation and isomerization of dietary fatty acids and the respiratory properties of rat heart mitochondria. | weanling rats were fed semi-purified diets containing 15% by weight of either corn oil, a high oleic acid safflower oil, lard or hydrogenated soybean oil. significant changes in the fatty acid composition of heart mitochondrial preparations were induced by these dietary fats. despite these changes in membrane composition, no effects on the respiratory properties of the mitochondria were observed. these results suggest that mitochondrial membranes adapt to changes in dietary fatty acids in a way ... | 1984 | 6696943 |
| the effect of dietary lipid on the lipoprotein status of the mongolian gerbil. | the mongolian gerbil, meriones unguiculatus, may be a suitable animal model for the investigation of dietary lipid effects on cholesterol metabolism. the effects of dietary cholesterol, and its possible interaction with the type of dietary fat, on the lipoprotein status of this animal have not been examined previously. in the present research, the effects of adding 0.5% cholesterol to diets high in saturated (19.5% beef tallow: 0.5% safflower oil) or polyunsaturated (20% safflower oil) fats on t ... | 1984 | 6708744 |
| effects of margarine on hepatocarcinogenesis by n,n'-2, 7-fluorenylenebisacetamide in mice. | the effect of a safflower margarine on hepatocarcinogenesis by n,n'-2, 7-fluorenylenebisacetamide was compared with that of safflower oil from which the margarine was made. a high-dextrin diet was used as a control for the two high-fat diets. the number of surviving mice in the margarine group at the end of the experiment was significantly lower compared with both the dextrin and the oil groups. a significantly high incidence of hepatic nodules type 2 was observed in the margarine group, whereas ... | 1984 | 6709273 |
| effect of dietary fats on desaturase activities and the biosynthesis of fatty acids in rat-liver microsomes. | four groups of rats were fed diets containing 15% (w/w) high-oleic safflower oil (sfo, rich in cis-18:1 acids), a mixture of 80% partially hydrogenated soybean oil plus 20% corn oil (h + co, rich in trans-18:1 acids), lard (l, rich in saturated fatty acids) and corn oil (co, rich in 18:2 omega 6). fatty acid composition of liver microsomes and activities of the delta 5, delta 6 and delta 9 desaturases were determined. microsomal delta 6 desaturase activity and arachidonic acid were lower in the ... | 1984 | 6717253 |
| effects of dietary vitamin e on serum and pulmonary fatty acids and prostaglandins in rats fed excess linoleic acid. | the interrelationships of dietary vitamin e and essential fatty acids and their effects on serum and pulmonary prostaglandin (pg) synthesis and fatty acid precursors were examined. in a preexperimental period, male weanling rats were depleted of essential fatty acids (efa) by feeding on a hydrogenated coconut oil diet. at the end of 45 days, average serum triene:tetraene ratio for the efa-deficient rats was 0.76. after a refeeding period with a 20% safflower oil diet and 0, 1 or 50 mg of dl-alph ... | 1984 | 6726476 |
| effect of several dermatitis preventing agents on foot pad dermatitis in dwarf and normal sized single comb white leghorn layers. | studies were conducted to determine the effects of increased dietary levels of vitamin and trace mineral mixtures, methionine, meat and bone meal, fish meal, and safflower oil on foot pad dermatitis in dwarf and normal size single comb white leghorn layers. all layers were maintained in individual wire cages throughout a 40-week experiment period. individual birds were scored for the incidence of foot pad dermatitis and production parameters were recorded. no significant decrease in the incidenc ... | 1984 | 6728807 |
| suppression by diets rich in fish oil of very low density lipoprotein production in man. | the highly polyunsaturated fatty acids in fish oils lower the plasma triglyceride concentration. we have studied the effect of a diet rich in fish oil on the rate of production of the triglyceride-transporting very low density lipoprotein (vldl). seven subjects, five normal and two with hypertriglyceridemia received up to 30% of daily energy needs from a fish oil preparation that was rich in eicosapentaenoic acid and docosahexaenoic acid, omega-3 fatty acids with five and six double bonds, respe ... | 1984 | 6736254 |
| energetic efficiency and mitochondrial function in rats fed trans fatty acids. | nutritional experiments with growing rats were conducted to study the effect of dietary t18:1 and t,t18:2 in mixtures with safflower oil (77.1% linoleate) on oxidative phosphorylation of isolated liver mitochondria and on energetic efficiency as measured in energy balance experiments. partially hydrogenated soybean oil (phso) with 45% t18:1 and an ethyl ester concentrate of trans fatty acids (trans) containing 52% t,t18:2 were used. six groups of male rats were fed diets with 10% (wt/wt) fat sup ... | 1984 | 6737083 |
| the biosynthesis of triacylglycerols in microsomal preparations of developing cotyledons of sunflower (helianthus annuus l.). | the synthesis of triacylglycerols was investigated in microsomes (microsomal fractions) prepared from the developing cotyledons of sunflower (helianthus annuus). particular emphasis was placed on the mechanisms involved in controlling the c18- unsaturated-fatty-acid content of the oils. we have demonstrated that the microsomes were capable of: the transfer of oleate from acyl-coa to position 2 of sn-phosphatidylcholine for its subsequent desaturation and the return of the polyunsaturated product ... | 1984 | 6743281 |
| augmentation of prostaglandin production by linoleic acid in man. | 1. since several lines of evidence have suggested that a diminution of endogenous prostaglandins (pg) may participate in the pathogenesis of a variety of disease states, it would be advantageous to develop therapeutic approaches that augment endogenous prostaglandin synthesis. since linoleic acid is readily converted to arachidonic acid, we assessed the effects of linoleic acid administration on immunoassayable pge and 6-oxo-pgf1 alpha excretion as indices of pge2 and pgi2 production. 2. six nor ... | 1982 | 6751651 |
| parenteral safflower oil emulsion (liposyn 10%): safety and effectiveness in treating or preventing essential fatty acid deficiency in surgical patients. | the safety and effectiveness of a 10% safflower oil emulsion in treating or preventing essential fatty acid deficiency was tested in a prospective study of 15 surgical patients requiring total parenteral nutrition for two to four weeks. three dosage regimens were evaluated including: group i: 4% of calories as linoleate daily (five patients), group ii: 4% of calories as linoleate every other day (two patients), and group iii: 8% of calories every other day (eight patients). patients were monitor ... | 1980 | 6767452 |
| safflower oil emulsion: single and multiple infusions with or without added heparin in normal human volunteers. | intravenous hyperalimentation in chronically ill patients has become increasingly common in hospitalized patients. total parenteral nutrition includes supply of carbohydrates, amino acids, and lipids. the safety of a new emulsion of safflower oil (liposyn 10%) infused by peripheral vein was evaluated in 15 normal male volunteers. all subjects tolerated liposyn infusion, with a low incidence of side effects, when given either as a single infusion or multiple daily infusions to provide 4% of daily ... | 1980 | 6772813 |
| pediatric tpn: efficacy and toxicity of a new fat emulsion. | fat emulsions are particularly valuable in pediatric total parenteral nutrition (tpn) because they provide an isotonic solution rich in calories. little is known about the ideal composition of fatty acid emulsions, however, and very few formulations are commercially available. a new fat emulsion using a safflower oil base has recently been approved. we have used this new emulsion to provide a significant percentage of the nonprotein caloric requirements (24 to 42%) in 4 patients requiring tpn. t ... | 1980 | 6774121 |
| comparison of a new 10% and 20% safflower oil fat emulsion in pediatric parenteral nutrition. | a new 20% safflower oil fat emulsion was compared with its 10% counterpart in a small series of pediatric patients. five infants and children, studied for a 2-week period, received either the 10% or 20% emulsion for 1 week and the other emulsion the 2nd week. no serious toxicity or side effects were noted in any of the patients following the infusion of either emulsion. in addition, significant weight gain was noted in the children, and clinical improvement was apparent in all cases. this prelim ... | 1981 | 6788973 |
| assessment of the essential fatty acid requirement in gerbils by polyunsaturated fatty acid ratio. | essential fatty acid status in the gerbil was assessed using the ratio of 20:3 omega 9 (5,8,11-eicosatrienoic acid) to 20:4 omega 6 (arachidonic acid) derived from liver phospholipid. both a fat-free diet and a diet containing 20% hydrogenated coconut oil produced an essential fatty acid deficiency. the minimum requirement for 18:2 omega 6 (linoleic acid) in the gerbil, like that in the rat, was estimated at 1% kcal of the diet when graded levels of safflower oil were added to a purified diet co ... | 1981 | 6792330 |
| studies with a safflower oil emulsion in total parenteral nutrition. | the prevention of essential fatty acid deficiency and the provision of adequate amounts of energy are two major concerns in total parenteral nutrition. since earlier preparations of fat emulsion used to supplement the usual regimen of hypertonic glucose and amino acids have widely varying clinical acceptability, a new product, a safflower oil emulsion available in two concentrations (liposyn), was evaluated. in four clinical trials the emulsion was used as a supplement to total parenteral nutrit ... | 1981 | 6799182 |
| parenteral 20% safflower oil emulsion safety and effectiveness as a caloric source in newborn infants. | five surgical infants, ages 3 to 30 days, were studied while receiving peripheral total parenteral nutrition for a period of 2 weeks. by a randomized sequence, either 10 or 20% safflower oil emulsion was infused the first week, followed by the alternate solution during the second week. caloric intake was 80 to 100 cal/kg/day, of which lipids comprised one-third to one-half. no adverse side effects were noted. eosinophilia developed in three patients, but otherwise no changes in hematologic and b ... | 1982 | 6804651 |
| parenteral nutrition: current status and concepts. | parenteral nutrition is regarded as a form of nutrition in some countries and as an extension of intravenous fluid therapy in others. the optimum clinical application of parenteral nutrition as a form of therapy requires detailed knowledge of the nutrient solutions themselves, including the commonly used solutions such as dextrose, soybean oil emulsion, synthetic crystalline l-amino acid solutions; older solutions such as xylitol, protein hydrolysates; and newer solutions such as glycerides and ... | 1982 | 6806063 |
| changes in red cell membrane fatty acids in patients receiving total parenteral nutrition supplemented with a safflower oil emulsion. | previous studies in patients suffering from essential fatty acid deficiency (efad) have shown erythrocyte membrane fatty acids to change in parallel with those seen in plasma. a study was conducted to determine if this same relationship existed in patients that were not diagnosed as having efad. three subjects maintained on parenteral nutrition were given 500 milliliters of a safflower oil emulsion twice weekly for 14 days. plasma and red blood cell membrane fatty acids were determined before an ... | 1982 | 6809975 |
| studies on the efficacy of a new 20% fat emulsion in pediatric parenteral nutrition. | a new 20% safflower oil emulsion was studied in a small series of pediatric patients. eight infants and children were evaluated over a 2-week period. the 20% fat emulsion supplied a major portion of daily caloric requirements. no serious side effects or toxicity were noted. no major changes in blood chemistries were observed; however, a statistically significant increase in serum albumin was noted. in addition, 63% of the patients gained weight during the study. this investigation supports the c ... | 1982 | 6809978 |
| the effect of two intravenous fat emulsions and their components on bilirubin binding to albumin. | the effect of two intravenous lipid emulsions on the binding of bilirubin to albumin was investigated in vitro. various concentrations of a soybean (intralipid) or a safflower (liposyn) oil emulsion in 0.48 mm albumin were assayed for changed in bilirubin displacement using sephadex g-25 gel filtration and for alternations of albumin reserve binding capacity by a novel difference spectroscopy technique. two major components of the emulsions, glycerol and egg phosphatides, were also assayed by di ... | 1982 | 6810688 |
| a clinical evaluation of safflower oil emulsion in total parenteral nutrition. | a new intravenous safflower oil emulsion (liposyn, abbott) was administered to 23 patients receiving total parenteral nutrition. in a prospective clinical trial, 500 ml of the 10% emulsion was administered each day for a minimum of 10 days. plasma fatty acid estimations showed a rise in linoleic acid in 22 patients, and a fall in triene/tetraene ratio ( a guide to the presence of essential fatty acid deficiency), in 17 patients within four days of commencement of the infusion. administration of ... | 1982 | 6812458 |
| tissue content and metabolism of myo-inositol in normal and lipodystrophic gerbils. | experiments were conducted to evaluate the effect of diet and sex difference on the development of an intestinal lipodystrophy due to myo-inositol deficiency. tissue contents of free and lipid-bound myo-inositol as well as the activities of l-myo-inositol-l-phosphate synthase (ec 5.5.1.4) and phosphatase (ec 3.1.3.25), and myo-inositol oxygenase (ec 1.13.99.1) were determined in male and female gerbils under various conditions. the enzyme study proved that the essentiality of dietary myo-inosito ... | 1983 | 6822903 |
| the role of the acyl-coa pool in the synthesis of polyunsaturated 18-carbon fatty acids and triacylglycerol production in the microsomes of developing safflower seeds. | microsomes isolated from the developing cotyledons of the seeds of the safflower varieties, very-high-linoleate, gila and high-oleate, were capable of exchanging the acyl groups in acyl-coa with the fatty acids in position 2 of phosphatidylcholine. the specificity of the 'acyl-exchange' towards the acyl moiety in acyl-coa was selective in the order: oleate greater than linoleate greater than linolenate. stearoyl-coa was completely selected against when presented in a mixed substrate with unsatur ... | 1983 | 6860695 |
| essential fatty acids in the serum and cerebrospinal fluid of multiple sclerosis patients. | statistical evaluation of essential fatty acids (determined by gas chromatography) in the serum and cerebrospinal fluid of patients with definite ms and acute cct showed marked differences as compared to healthy subjects. it was also evident that the decrease of essential fatty acids in ms patients differed from that of cct patients. whereas the fatty acid levels in the serum of ms patients revealed only minor differences as compared to the controls and cct patients, ms patients did show a clear ... | 1983 | 6868953 |
| the effect of aspirin and linoleic acid on platelet aggregation, platelet fatty acid composition and haemostasis in man. | the effect of linoleic acid and of aspirin on platelet aggregation has been measured in six healthy volunteers with a new platelet aggregometer (wellcome) designed to be used with whole blood. the subjects were given a controlled diet for 6 weeks during which their platelet aggregation, platelet fatty acid composition, dilute blood clot lysis time, bleeding time and serum cholesterol and triglycerides were measured. a basal diet typical of that normally eaten in the uk was fed for 3 weeks, then ... | 1983 | 6874413 |
| effects of dietary trans-fat on biliary and fecal steroid excretion and serum lipoproteins in rats. | rats were fed cholesterol-free or cholesterol-enriched diets containing olive oil or partially hydrogenated corn oil at the 10% level for ca. 30 days (c-18:1, 77.0% in the former diet and c-18:1,24.7% and t-18:1,42.5% in the latter). the linoleic acid content of these fat diets was made equivalent (1.7 energy %). after feeding cholesterol-free diets, trans fat compared to cis fat showed (a) no untoward effects on growth parameters, (b) a reduction of serum cholesterol levels without influencing ... | 1983 | 6877041 |