| synthesis and biological activity of 10-thia-10-deaza analogs of folic acid, pteroic acid, and related compounds. | the 10-thia analogs of pteroic acid, folic acid, their esters, and their 4-amino analogs were synthesized through a reaction sequence involving, as a key step, the condensation of 2-amino-3-cyano-5-chloromethylpyrazine with appropriately substituted thiols. the abilities of the products to inhibit the growth of methotrexate (mtx)-sensitive and mtx-resistant microorganisms were investigated as were their abilities to inhibit dihydrofolic acid reductase and thymidylic acid synthetase. several comp ... | 1975 | 808608 |
| synthesis and biological activity of 5-fluoro-4'-thiouridine and some related nucleosides. | the synthesis of a series of 4'-thio-5-halogenopyrimidine nucleosides, including the 5-fluoro, chloro, bromo and iodo derivatives, has been carried out by condensation of the 2,4-bis-o-trimethylsilyl derivatives of the corresponding pyrimidine bases with the protected 4-thio-d-ribofuranosyl chloride. among these, the alpha and beta anomers of 4'-thio-5-fluorouridine inhibited the growth of leukemia l1210 cells at concentrations of 4 x 10(-7) and 2 x 10(-7) m, respectively, and that of s. faecium ... | 1975 | 808609 |
| methotrexate analogs. 6. replacement of glutamic acid by various amino acid esters and amines. | a series of methotrexate (mtx) analogs was prepared in which the glutamic acid moiety is replaced by various amino acid esters and amines. the synthetic method consisted of the reaction of 4-amino-4-deoxy-n10-methylpteroic acid with various reagents to form intermediate mixed anhydrides, which then reacted with amino acid esters or amines to give the mtx analogs. these compounds were tested for antibacterial activity against streptococcus faecium and for antitumor activity against l1210 leukemia ... | 1975 | 808614 |
| [bacteriological detection of asymptomatic urinary tract infections]. | | 1975 | 808673 |
| detection of bacteriuria in pediatric outpatients. a new culture device. | urine samples from 1,003 pediatric patients were examined for bacteriuria with a culture-nitrite strip test, along with microscopic assessment of pyruia and conventional chemical analysis. the latter two methods proved of little value in reliably detecting or excluding substantial bacteriuria. an overall prevalence of 5.2% was shown. using microstix reagent strips, 92 urine samples with substantial colony counts were detected. subculture from the strips disclosed that 52 of these involved single ... | 1975 | 808961 |
| an assessment of antibiotics for the treatment of pyogenic dental infections. | tests made with a series of antibiotics against a number of different organisms indicate that if clinical evidence suggests a streptococcal infection, penicillin should be used otherwise erythromycin is preferred. | 1975 | 809025 |
| effect of hyperbaric helium on vitamin uptake and utilization by micro-organisms. | growth responses under hyperbaric helium of various procaryotic micro-organisms to graded levels of six water-soluble vitamins were measured. vitamins included: thiamin, riboflavin, niacin, pantothenic acid, biotin, and folic acid (folacin). growth response of each organism under hyperbaric helium was compared with that under 80% he-20% o2 and other he-o2 gas mixtures at atmospheric pressure, and with response in air at atmospheric pressure. for five of the six vitamins, no differences in respon ... | 1975 | 809032 |
| [effect of the combination of 5-methylquinolin-8-ol, 7-bromo-5-methylquinolin-8-ol and 5-methylquinolin-8-ol-dodecylsulfate on the intestinal flora of healthy subjects]. | the influence of a combination of 5-methyl-quinolin-8-ol, 7-bromo-5-methyl-quinolin-8-ol with 5-methyl-quinolin-8-ol-dodecylsulfate on the composition of intestinal bacteria of healthy adults has been examined. the composition of normal anaerobic and aerobic intestinal bacteria practically showed no change. | 1975 | 809045 |
| the structure of dihydrofolate reductase. identification of methionine residues carboxymethylated by iodoacetate with loss of catalytic activity. | dihydrofolate reductase from the amethopterin-resistant mutant (strain a) of streptococcus faecium var. durans was reacted with iodo[14c]acetate according to three procedures; (a) in the absence of an inhibitor, (b) in the presence of aminopterin, and (c) in absence of inhibitor, but after treatment with unlabeled iodoacetate in presence of aminopterin. the first and last procedures resulted in the loss of approximately 90% of the catalytic activity, whereas in the presence of aminopterin essent ... | 1975 | 809271 |
| antibacterial activity of human cervical mucus. | the antimicrobial property of human uterine cervical mucus was tested in three groups of women. healthy women, using no contraception, women using an intrauterine device and women receiving hormonal treatment for contraception. cervical mucus was taken on the 10th, 14th, 18th and 22nd day of the menstrual cycle. cervical mucus had a strong inhibitory effect on the growth of micrococcus lysodeicticus in all three groups. the strength of the inhibitory effect on the other microorganisms were in t ... | 1975 | 809320 |
| osteomyelitis caused by streptococcus faecalis (report of an unusual case). | | 1975 | 809352 |
| evidence for the synthesis of soluble peptidoglycan fragments by protoplasts of streptococcus faecalis. | growing protoplasts of streptococcus faecalis 9790 were found to synthesize and excrete soluble peptidoglycan fragments. the presence of soluble peptidoglycan derivatives in culture supernatants was determined by (i) incorporation of three different radioactively labeled precursors (l-lysine, d-alanine, and acetate) into products which, after hen egg-white lysozyme hydrolysis, had the same kd values on gel filtration as muramidase hydrolysis products of isolated walls; (ii) inhibition of net syn ... | 1975 | 809417 |
| characterization of the presumed peptide cross-links in the soluble peptidoglycan fragments synthesized by protoplasts of streptococcus faecalis. | protoplasts of streptococcus faecalis atcc 9790 were produced with the aid of lysozyme, and the ability of these bodies to synthesize soluble, peptide cross-linked peptidoglycan (pg) fragments was examined. lysozyme digests of pg isolated using gel filtration from the supernatant medium of protoplasts grown in the presence of [14c]acetate and l-[3h]lysine contained small amounts of pg having kd expected for peptide cross-linked dimers and trimers. addition of benzyl penicillin (300 mug/ml) to gr ... | 1975 | 809418 |
| synthesis of peptidoglycan in the form of soluble glycan chains by growing protoplasts (autoplasts) of streptococcus faecalis. | protoplasts (autoplasts) of streptococcus faecalis were produced by the action of native autolytic n-acetylmuramidase in the absence of added peptidoglycan hydrolases and were grown in osmotically stabilized medium containing l-[3h]lysine and d-[14c]alanine. to reduce the level of muralytic hydrolysis of glycan chains during growth, heat-inactivated cell walls were added to the medium to bind autolytic enzyme, and tetracycline (1 mug/ml) was added to inhibit further enzyme synthesis. under these ... | 1975 | 809419 |
| nucleic acid related compounds. 17.3-deazuridine. stannous chloride catalysis of cis-diol vs. phenolic base methylation with diazomethane. | treatment of a methanolic solution of 4-hydroxy-1-beta-d-ribofuranosyl-2-pyridinone (3-deazauridine, 1) with diazomethane gave 2-methoxy-1-beta-d-ribofuranosyl-4-pyridinone (2) and 4-methoxy-1-beta-d-ribofuranosyl-2-pyridinone (3a) in an approximate ratio of 1:2. analogous treatment of 1 with diazomethane in the presence of stannous chloride dihydrate gave eight detected products including 2, 2-methoxy-1-(2-o-methyl-beta-d-ribofuranosyl)-4-phridinone (4), 2-methoxy-1-(3-o-methyl-beta-d-ribofuran ... | 1975 | 809580 |
| 'single-stranded' dna from phix174 and m13 is cleaved by certain restriction endonucleases. | | 1975 | 809717 |
| [change in the accumulation of dibenzyldimethylammonium by irradiated cells of streptococcus under the effects of modifiers of radiation injury]. | | 1975 | 810185 |
| relationship between various bacterial populations and coprostanol and cholesterol. | a year-long study was conducted at three different locations in canada to evaluate the relationship between fecal sterols and bacterial populations. a statistical model was constructed to study the following: (i) seasonal variations in the sterols and bacterial parameters; (ii) the differences between morning and afternoon samples; (iii) the relationship between the two sterols (coprostanol and cholesterol) as well as their relationship to the bacterial parameters; and (iv) the geographical diff ... | 1975 | 810236 |
| survival of salmonella and other indicator microorganisms. | survival times for enteric bacteria and fecal streptococci were investigated using filter-sterilized water from a northern illinois river and temperatures of 0 degrees, 5 degrees, 10 degrees, and 20 degrees c. survival of salmonella typhimurium was essentially the same as escherichia coli over normal seasonal temperatures. fecal streptococci generally exhibited classic survival patterns. | 1975 | 810237 |
| streptococcal infections--updated. | streptococci are amont the most common bacterial pathogens physicians encounter in practice. infections with streptococci continue to occur with significant frequency despite the general sensitivity of these organisms to a variety of widely used antibiotics. in newborn infants and other special patient groups, streptococci may produce fulminant and fatal sepsis (table 1). in normal children and adults, infections usually are short term and often mild or unrecognized but with the possibility of r ... | 1975 | 810336 |
| the antibacterial and pharmacological activity of oxolinic acid (prodoxol). | | 1975 | 810473 |
| transmissible toxin (hemolysin) plasmid in streptococcus faecalis and its mobilization of a noninfectious drug resistance plasmid. | streptococcus faecalis strain ds-5 has been shown previously to contain three plasmids, pamalpha1, pambeta1, and pamgamma1. mixed incubation of ds-5 with strain jh2-2, a plasmid-free s. faecalis recipient, results in the transfer of pamalpha1 (which determines resistance to tetracycline) and/or pamgamma1. analyses of recipients carrying various combinations of these plasmids have revealed the pamgamma1 codes for toxin (hemolysin) production and two bacteriocin activities. jh2-2 strains carrying ... | 1975 | 810482 |
| phage typing scheme for group d streptococci isolated from human urogenital tract. | streptococci of lancefield group d were isolated from 52.2% of pharyngeal, 55.5% of urethral, 56.6% of endocervical, and 75.4% of ano-rectal specimens. seventeen phages isolated from sewage and urogenital specimens were selected for phage typing. four of these lysed only the strains of streptococcus faecalis and its variety liquefaciens. another six phages lysed only the strains of streptococcus faecium and its variety durans. with the help of seven bacteriophages, 346 of 384 (90.1%) strains of ... | 1975 | 810495 |
| [effects of formula diet with varying carbohydrate proportion on gut microflora in man]. | the effects of conventional food and of formula diet on gut microflora were tested in six healthy persons. in comparison with conventional food, the total gut microflora concentrations slightly increased during formula diet with oligosaccharides. during the periods of formula diet rich in sucrose of maltose, total flora concentrations declined. these changes of total gut microflora were especially caused by the increase and decrease of the enterococci and enterobacteria, the bacteroides showing ... | 1975 | 810751 |
| streptococcus faecalis and streptococcus faecium in infected dental root canals at filling and their susceptibility to azidocillin and some comparable antibiotics. | the study was performed on 612 routine cultures of material obtained from root canals of teeth at the time of filling (r-cultures) by students at the department of endodontics during a continuous period of one year. twenty-nine isolates from 27 (29.3%) of the 92 positive cultures filled the criteria of enterococci (sherman, 1937) and had demonstrable group d-antigen. with a set of tests these isolates were identified as follows: strep. faecalis subsp. faecalis (10), strep. faecalis subsp. zymoge ... | 1975 | 810753 |
| the effect of neutralizing agents on aqueous parachlorophenol. | the effect of possible neutralizing agents on aqueous parachlorophenol were studied. results indicated that saline, edtac, dentin, saliva, prolonged light exposure, and thermal extremes do not appreciably affect the antibacterial properties of aqueous parachlorophenol. the presence of blood and necrotic tissue demonstrated a marked inhibitory effect. | 1975 | 810757 |
| experimental intestinal granulomas. | | 1975 | 810807 |
| [study of enterococci in milk]. | studied were a total of 270 samples of raw and pasteurized milk taken during the various technologic states of pasteurized mild produced for consumption at the state economic enterprise "serdica", establishing the enterococcus and coli titers. it was found that the enterococcus titer of the raw milk varies from 10(-3) up to 10(-6), and the titer of the pasteurized milk at the enterprise and upon delivery through its commercial channels is from 1 up to 10(-3). the enterococcus titer of milk that ... | 1975 | 810940 |
| glomerular and vascular lesions in chronic atrophic pyelonephritis and reflux nephropathy. | | 1975 | 811093 |
| inhibition of microorganisms by pyrimidine nucleosides. | | 1975 | 811152 |
| evaluation of a most-probable-number technique for the enumeration of pseudomonas aeruginosa. | a most-probable-number (mpn) technique was evaluated for detecting and enumerating pseudomonas aeruginosa in water and wastewater. both the presumptive and confirmatory media, as described in the 13th edition of standard methods for the examination of water and wastewater, as well as modifications of these media were included in evaluations. various samples of water were tested, namely chlorinated tap water, creek water, and influent to a wastewater treatment plant. modified media repeatedly gav ... | 1975 | 811166 |
| distribution and significance of fecal indicator organisms in the upper chesapeake bay. | total viable aerobic, heterotrophic bacteria, total coliforms, fecal coliforms, and fecal streptococci were enumerated in samples collected at five stations located in the upper chesapeake bay, december 1973 through december 1974. significant levels of pollution indicator organisms were detected at all of the stations sampled. highest counts were observed in samples collected at the confluence of the susquehanna river and the chesapeake bay. the indicator organisms examined were observed to be q ... | 1975 | 811167 |
| prophylactic interparietal povidone-iodine in abdominal surgery. | this study sought to determine in a district general hospital (a) the frequency and nature of bacterial contamination at operation, (b) the incidence of consequent infection and (c) the prophylactic effect, if any, of interparietal povidone-iodine against postoperative wound infection. bacterial contamination was shown in 49 per cent of all the abdominal surgical wounds at the end of operation. from 61 per cent of the subsequently infected wounds, organisms identified as contaminants at operatio ... | 1975 | 811302 |
| morphology and viability of large bodies of streptococcal l-forms. | a procedure is described for the massive formation and isolation of large bodies of group a and d streptococcal l-forms. up to 90% individual bodies of 20 to 100 mum in diameter can be produced in pour plates of nutrient gelatin and subsequently harvested by simple micromanipulation. the growth of these giant bodies was followed by light microscopy and their ultrastructure and internal architecture was examined by transmission and scanning electron microscopy. large bodies had a honeycomb struct ... | 1975 | 811562 |
| selective adhesion of microorganisms to the ductular epithelium of the bovine mammary gland. | streptococcus agalactiae, streptococcus faecalis, staphylococcus aureus, escherichia coli, and corynebacterium bovis were examined for their ability to adhere to the ductular epithelial cells of the bovine udder. s. agalactiae and s. aureus adhered readily and in large numbers, whereas the other organisms adhered poorly or not at all. the organisms showing the ability to adhere are those which frequently cause mastitis. these data suggest that selective adherence to the ductular epithelium may b ... | 1975 | 811566 |
| adherence of bacteria to heart valves in vitro. | the abilities of 14 strains of aerobic gram-positive cocci and gram-negative bacilli to adhere in vitro to human or canine aortic valve leaflets were compared. 2-mm sections of excised valve leaflets were obtained by punch biopsy and were incubated under standardized conditions in suspensions of bacteria. valve sections were subsequently washed and homogenized, and quantitative techniques were used to determine the proportions of bacteria from the initial suspensions that had adhered to the valv ... | 1975 | 811687 |
| streptococcus faecalis chain disruption. | | 1975 | 811762 |
| quinazolines as inhibitors of dihydrofolate reductase. 3. analogs of pteroic and isopteroic acids. | a series of 19 quinazoline analogs of pteroic and isopteroic acid was prepared with particular emphasis being placed upon carboxylic acid esters. each compound was evaluated as an inhibitor of the dihydrofolate reductases from rat liver as well as from streptococcus faecium. several of the more potent inhibitors were found to be inactive against l1210 leukemia in mice at low dose levels and were lethal to mice at 100 mg/kg. six compounds were also evaluated for antimalarial activity against plas ... | 1975 | 811798 |
| 3-acyloxymethyl-7-(2-thienylacetamido)-3-cephem-4-carboxylic acids. an improved synthesis and biological properties. | | 1975 | 811800 |
| studies on the establishment of multi-drug-resistant strain bio-4r of streptococcus faecalis in the intestinal tract of germ-free mice. bacterial interaction and effect of antibiotics. | germ-free icr mice were mono- or dicontaminated with a multi-drug-resistant strain bio-4r of streptococcus faecalis (bio-4r) and escherichia coli 026 : k60 (e. coli) and administered aminobenzyl penicillin (abpc). bio-4r was established in the intestinal tract at a level of 10(8) viable cells per gram of stool on the fourth day following oral inoculation and the bio-4r population was stably maintained thereafter. the drug resistance of bio-4r remained unchanged in the intestinal tract of gnotobi ... | 1975 | 811833 |
| cellular immunity in experimental pyelonephritis. | | 1975 | 811919 |
| [comparative study of some quaternary ammoniums neutralizing agents. influence of the nature of the bacterial strains used]. | the neutralising capacity of the anti-bacterial activity of a quaternary ammonium salt, depends on the nature of the bacterial strains used. consequently, the choice of a neutralising agent of the bactericidal activity can only be made following a preliminary study on several bacterial species. out of five products which we tested, we found the tween-lecithin fresh egg mixture alone had satisfactory activity. | 1975 | 812041 |
| ecological studies of the microbial flora of the female lower genital tract. | | 1975 | 812101 |
| [studies on enterocinogens of enterococci present in food products and of their role in the mechanism of antagonisms]. | | 1975 | 812169 |
| [comparative studies on the disinfection effect of bromine and chlorine in swimming pools and model tests]. | | 1975 | 812178 |
| [microflora and immunity in surgical patients. i. some microfloral indices in the pre- and postoperative periods]. | surgical treatment can lead to the appearance of a purulent staphylococcus infection of endogenous etiology. endogenous infection originates as a result of the patient's diminished resistance, indicated by an increase in the number of pathogenic staphylococci, the appearance of representatives of the intestinal flora in the oral cavity and on the surface of the skin. no iogenous purulent infection. | 1975 | 812300 |
| [biocenotic dynamics of liquid sewage in the process of its biological purification at aeration stations]. | a study was made of biological purification of sewage at the aeration stations on the quantitative composition of the main indicator microbes--of bacteria of the coliform group and of the fecal coliform bacilli, enterococci, proteus, and also pathogenic enterobacteria. there was found a difference in the behaviour of different species of proteus, i.e. reduction in the process of purification in the numbers of pr. mirabilis, and a sharp elevation of pr. morganii content. there was noted an insign ... | 1975 | 812301 |
| seasonal occurrence and distribution of microbial indicators and pathogens in the rhode river of chesapeake bay. | the seasonal incidence and occurrence of indicator organisms and pathogens were studied at four sites in the rhode river, a subestuary of chesapeake bay. the highest frequency of occurrence of total and fecal coliforms and fecal streptococci was in muddy creek, a marsh area receiving pasture land runoff. second highest frequency of occurrence of these bacteria was in cadle creek, a populated area. lowest measurements of these parameters were obtained at stations in the central portion of the rho ... | 1975 | 812423 |
| role of amino acids on the growth and lipase production of streptococcus faecalis. | a study was conducted on the requirement of amino acids for the growth of s. faecalis and its lipase production. arginine, glutamic acid, histidine, leucine, isoleucine, methionine, threonine, tryptophane and valine were found to be essential, with alanine, glycine, lysine and serine as stimulatory and aspartic acid, cystine, phenylalanine, proline and tyrosine as non-essential for both growth and lipase synthesis. | 1975 | 812727 |
| studies of balanced and unblaanced growth of streptococcus mutans. | | 1976 | 812891 |
| chronic granulomatous disease in an adult male: a proposed x-linked defect. | a 25-year old patient with chronic granulomatous disease of somewhat unusual history is described. the diagnosis of cgd was based on increased susceptibility to infection, granulomatous appearance of tissues, and diminished bactericidal and metabolic response of leukocytes during phagocytosis: the clinical and cellular features considered phenotypic of cgd. a 16-year-old female sibling had bactericidal and metabolic abnormalities of leukocyte function similar to those of the patient's leukocytes ... | 1976 | 812972 |
| synthesis of inhibitors of bacterial cell wall biogenesis. analogs of d-alanyl-d-alanine. | | 1976 | 812991 |
| chemistry and antibacterial activity of nitrobenzofurans. | thirteen 2-methylbenzofurans were synthesized and their antibacterial activity was investigated. 2-methyl-3-nitrobenzofuran and analogs containing 7-no2, 5-no2, 7-br, 7-conh2, and 7-cf3 substituents are bacteriostatic. the spectrum of activity of these compounds is similar to nitrofurazone; however, a strain of e. coli br which has increased resistance to nitrofurazone did not show increased resistance to 3,7-dinitro-2-methylbenzofuran (1). the 3-nitro-2-methylbenzofurans are labile in solution ... | 1976 | 812994 |
| the faecal flora in ulcerative colitis. | differential counts of the faecal flora of patients with ulcerative colitis showed a dysbiotic flora with a 100-fold increase of group-d streptococci and a reduction of bifidobacteria in comparison with the stable eubiotic flora of healthy subjects. the increase in number in group-d streptococci was accompanied by an increase in variety. about four different varieties of enterococci were found in faeces from patients compared with one or two in samples from healthy subjects. the strains isolated ... | 1975 | 812997 |
| [the antifolic activity of several derivatives of 2,4,6-triaminopyrimidine and 2,6-diaminopurine in a microbiologic test system]. | | 1975 | 813381 |
| severe disabling polyarthritis associated with bacterial endocarditis. | | 1975 | 813398 |
| infection following total hip replacement in a general hospital without special orthopaedic facilities. | infection following total hip replacement is a serious complication for it is frequently impossible to resolve without removal of the prosthesis. we have reviewed 321 total hip replacements undertaken in a general hospital without special orthopaedic theatres. there were 17 deep infections, nine early and eight late. athough the diagnosis of early infection is usually not difficult, the differentiation between late infections, mechanical failure and metal sensitivity may be a problem. this paper ... | 1975 | 813492 |
| on the mode of action of 5-diazouracil on bacterial cell division. | cell division by strains of escherichia coli and salmonella typhimurium is inhibited by 5-diazouracil (5-du). division recovers in the presence of the inhibitor after a period which is temperature-dependent. recovery is probably due to breakdown of 5-du and the rate of this breakdown is apparently increased at alkaline ph. growth with 5-du caused only a slight reduction in the rate of murein synthesis and no alteration in the properties or composition of membranes of s. typhimurium. the agent ca ... | 1976 | 813834 |
| activation of lipolytic activity of streptococcus faecalis by nitrosoguanidine. | | 1976 | 814069 |
| microbial synergy in experimental intra-abdominal abscess. | intra-abdominal sepsis was studied in wistar rats by using four microbial species: escherichia coli, enterococci, bacteroides fragilis, and fusobacterium varium. these organisms were implanted into the peritoneal cavity singly and in all possible dual combinations. results were evaluated by mortality rates and the incidence of intra-abdominal abscesses on autopsy following sacrifice after 7 days. mortality was restricted to recipients of e. coli, thus implicating coliforms in the acute lethality ... | 1976 | 814099 |
| selective adherence as a determinant of the host tropisms of certain indigenous and pathogenic bacteria. | the relationship between the selective abilities of bacteria to adhere and their predilections for colonizing different mammalian hosts was investigated by using bacteria indigenous to the tongue dorsum of humans and rats as models. streptococcus salivarius and s. sanguis averaged 22.6 and 2.8%, respectively, of the cultivable bacteria recovered from swab samples of the tonges of five humans, but these organisms were not indigenous on the tongues of rats (charles river strain). s. faecalis and s ... | 1976 | 814100 |
| bacterial endocarditis. echocardiographic and clinical evaluation during therapy. | in two patients with bacterial endocarditis and apparent vegetations, the echocardiographic findings included thickening but normal excursion of the mitral leaflet and abnormal shaggy echoes superimposed on the mitral leaflet echogram. both patients had had endocarditis several weeks before the study was performed. in both patients the abnormal echoes disappeared after antibiotic therapy. whether or not the echocardiographic findings are specific to bacterial endocarditis must be determined by f ... | 1976 | 814136 |
| antimicrobial efficacy of reduced concentrations of parachlorophenol in extracted teeth. | | 1975 | 814185 |
| racemic diastereoisomers of 1-amino-2-hydroxycyclopentanecarboxylic acid. | the synthesis and characterization of the two diastereoisomeric forms of 1-amino-2-hydroxycyclopentanecarboxylic acid have been accomplished. a previously reported synthesis produced a racemic mixture of the threonine analog trans-2-hydroxy-1-aminocyclopentanecarboxylic acid (trans with respect to the hydroxy and carboxyl group). the alternate allothreonine analog was produced by conversion of cyclopentene oxide to trans-2-methoxycyclopentanol, followed by oxidation to 2-methoxycyclopentanone an ... | 1976 | 814238 |
| products from furans. 1. sunthesis and anticoccidial and antimicrobial activity of 5-amino-5,6-dihydro-6-methoxy-2-methyl-2-(4'-biphenylyl)-2h-pyran-3(4h)-ones and related compounds. | a michael type addition of an amine to 6-methoxy-2-methyl-2-(4'-biphenylyl)-2h-pyran-3(6h)-one (1) dissolved in ether, benzene, or thf gave 5-amino derivatives of 5,6-dihydro-6-methoxy-2-methyl-2-(4'-biphenylyl)-2h-pyran-3(4h)-one (2). these by subsequent reduction with lialh4 were converted to 5-amino derivatives of 6-methoxy-2-methyl-2-(4'-biphenylyl)tetrahydro-2h-pyran-3-ol (3). both isomers a and b of 1 (in regard to the methoxy group at c6) were used for the synthesis of 2 and 3. the in vit ... | 1976 | 814239 |
| [inoculability and bacteriocinogenic activity of enterococci]. | | 1975 | 814387 |
| microstix-a reagent strip for urine culture. | microstix is a simple and convenient reagent strip for obtaining a semi-quantitative bacterial count on urine specimens. this method correctly predicted over 10(5) gram-negative organisms per ml in 84 percent of samples and over 10(5) gram-positive organisms per ml in 72 percent. urine specimens containing 10(4) per ml or more of any organism should be recultured using fully quantitative methods. if this criterion had been used 89 percent of urine samples with over 10(5) organisms per ml would h ... | 1975 | 814509 |
| a sensitive radioactive method for determination of glutamine. | | 1975 | 814840 |
| the effect of cooling and warming rates on the survival of a variety of bacteria. | cooling and warming rates affect bacterial survival profoundly with all bacteria tested (azotobacter chroococcum, klebsiella aerogenes, salmonella typhimurium, pseudomonas aeruginosa, streptococcus faecalis) behaving similarly. most bacteria were sensitive to salt on freezing and thawing. viabilities of population frozen and thawed in saline were always less (by at least 20%) than comparable ones frozen in water alone. under these conditions, s. faecalis was resistant to the presence of sodium c ... | 1976 | 814981 |
| chemical modification of peptide antibiotics : part iii. biological activities of some ethanolamine and tryptophan derivatives and of some polypeptides containing tryptophan. | | 1975 | 815158 |
| importance of streptococci as pathogens in the urinary tract. | streptococcus faecalis, while the most common streptococcal serotype causing urinary tract infection, is not the only one. lancefield group a, b, c and g serotypes are capable of invading the urinary tract. this finding is not generally appreciated. the reason for this anomaly is seen in the failure of most investigators to utilise a definitive procedure to group streptococcal isolates from urine. streptococci are responsible for 8.5 percent of urinary tract infections in this hospital. | 1975 | 815857 |
| accelerated healing in infected wounds. | the effect of a standardized infection of pure and mixed cultures of gram-negative bacteria and a gram-positive coccus was studied in laparotomy wounds of rats. the infections were significantly stronger than in the control group wounds in 14 of 15 comparisons. this increased strength could not be correlated with an increased wound content of collagen. results of histologic studies showed a vigorous inflammatory response which probably was responsible for the increased strength. there was a sugg ... | 1976 | 816018 |
| [studies on the growth requirements of enterococci (author's transl)]. | the growth requirements of biochemically defined strains of the enterococcus species streptococcus faecium, s. faecalis, s. faecalis var. zymogenes and s. faecalis var. liquefaciens were compared. arginine, glutamic acid, histidine, leucine, methionine and valine were essential and isoleucine, tryptophan, adenine and uracil were stimulatory to growth for all testes strains. variation in the specific requirements occur for alanine, glycine, and serine representing strains differences. threonine w ... | 1975 | 816110 |
| sepsis of urological origin: microbiological aspects. | | 1976 | 816246 |
| persistence of human enteric bacteria in the canadian north. | | 1976 | 816448 |
| laser differential light-scattering bioassay for methotrexate (nsc-740). | a new bioassay method utilizing laser light scattering from suspensions of drug-sensitive bacteria has been developed for the estimation of antitumor drugs in biologic samples. changes in the light-scattering patterns of antibiotic-treated bacteria have recently been shown to provide a rapid and accurate indication of antibiotic sensitivity. similar considerations for several antitumor drugs have shown the method capable of assaying 0.1 ml with drug concentrations as low as a few nanograms of dr ... | 1976 | 816466 |
| inhibition of wall autolysis in streptococcus faecalis by lipoteichoic acid and lipids. | fully acylated lipoteichoic acid (lta) isolated from streptococcus faecalis atcc9790 (s. faecium) inhibited autolysis of walls from the same organism at concentrations (1.0 to 1.5 nmol of lta per mg of wall) comparable to those found in intact cells. partially deacylated lta isolated from s. faecalis or chemically deacylated lta failed to inhibit significantly in the same concentration range. beef heart cardiolipin and commercially obtained dipalmitoyl phosphatidyl glycerol were also found to in ... | 1976 | 816773 |
| specificity of bacterial ribosomes and messenger ribonucleic acids in protein synthesis reactions in vitro. | ribosomes from two gram-negative bacteria translated f2 rna, t4 early mrna, mrna from three gran-negative bacteria, and mrna from six gram-positive bacteria; ribosomes from three gram-positive bacteria translated mrna from the gram-positive strains, but did not translate the other mrnas. ribosomes from the gram-negative bacterium escherichia coli translated synthetic poly(u,g) but ribosomes from the gram-positive bacterium clostridium pasteurianum translated poly(u,g) very poorly, mrna from gram ... | 1976 | 816792 |
| conformation differences in bacterial ribosomal rna's in non-denaturing conditions. | | 1976 | 817211 |
| [studies on the antimicrobial properties of some bulgarian essential oils]. | | 1975 | 817513 |
| incidence and etiology of septic meningitis in a metropolitan county hospital. | from january 1, 1969 to december 31, 1974, 98,446 patients were admitted to ben taub general hospital, one of the harris county district hospitals and a major teaching institution for baylor college of medicine. spinal fluid specimens from 17,638 (17.9%) patients were cultured, and 787 (4.5%) cultures were positive for pathogenic microorganisms. haemophilus influenzae, type b, was most frequently isolated (23.8%), followed by streptococcus pneumoniae (16.0%), staphylococcus aureus (9%), neisseri ... | 1976 | 817592 |
| studies on the antimicrobial activity of amniotic fluid. | sixty-one amniotic fluid samples from women in their second and third trimesters of pregnancy were examined for antimicrobial activity. seventy per cent of the fluids were found to be active. the factor or factors responsible for this activity were present in low concentrations. the presence of spermine in the fluids accounted for some of the antimicrobial activity. | 1976 | 817602 |
| streptococci isolated from bovine intramammary infections. | streptococcal isolates from 71 dairy herds considered free of streptococcus agalactiae were compared with isolates from 1 herd used in bovine mastitis research over a 12-year period. the incidence of streptococci was as follows: streptococcus uberis, 56.5%; enterococci, 24.2%; streptococcus dysgalactiae, 9.0%; streptococcus bovis, 5.1%; unclassified streptococci, 3.1%; streptococcus agalactiae, 1.5%; and lancefield group g streptococci, 0.7%. the incidence for these streptococci in the 2 groups ... | 1976 | 817626 |
| [effect of levomycetin on the microflora artificially introduced into the intestines of gnotobiotic chicks]. | levomycetin effect on the microflora introduced into the intestine of abiotic chickens was studied. levomycetin in a dose of 4 mg perosone chicken for 5 days provided a decrease in the number of bifidobacteria, lactobacteria, escherichia and enterococci by 100 to 10000 times and an increase in the number of candida or disbacteriosis in the intestine. the highest effect was observed with respect to multiplication of lactobacteria. this impaired the ecological quantitative ratio between the microo ... | 1975 | 817647 |
| an improved procedure for the assay of available lysine and methionine in feedstuffs using tetrahymena pyriformis w. | 1. a study was made of the assay of available lysine and available methionine using tetrahymena pyriformis w, as applied to a variety of protein-rich feedstuffs. 2. results were strongly influenced by the conditions under which the analyses were done. with most of the test samples predigestion with papain caused a large increase in the values obtained. 3. an improved assay procedure was developed which included enzymic predigestion of the test samples, "all-in" sterilization of the medium consti ... | 1976 | 817733 |
| urinary pathogens in the male. | evidence is presented that the pathogens causing urinary infection in boys differ significantly from those causing infection in girls and in adult males. studies of the prepuce floria in boys known to have had urinary infection and in matched controls suggest that the focus of infection is in the preputial sac or urethra rather than the bowel as in girls. it is suggested that the difference in infecting organisms in boys and in adult males may be related to prostatic secretion. | 1975 | 817760 |
| acromegaly, the systolic click syndrome, and group d streptococcal endocarditis. | a syndrome consisting of an apical systolic click and late systolic murmur appeared over a period of three months in a patient with acromegaly. levels of growth hormone were highest during this interval. as a result of group d streptococcal endocarditis three months later, the patient sustained cerebral embolism and acquired free mitral regurgitation from ruptured chordae tendineae. during follow-up over 18 months, neither the level of growth hormone nor the degree of mitral regurgitation change ... | 1976 | 817874 |
| bacteremias associated with routine hemorrhoidectomies. | | 1976 | 817876 |
| [interpretation of the structure of the hydrophobic region of biological membranes]. | | 1976 | 817884 |
| turbidimetric and diffusion assay of bacitracin in feeds. | a manual turbidimetric method for determining zinc or methylene disalicylate bacitracin in feeds was developed. when zinc ions (10-4m) were added to the medium and the phosphate ion concentration in standard solutions was decreased to 1%, the median response of streptococcus faecalis was about 0.038 unit. feeds analyzed by the turbidimetric assay should be prewashed with petroleum ether and extracted with pyridine as in 42.204. zinc bacitracin standards added to swine and broiler rations were re ... | 1976 | 818070 |
| nonspecific complement activation by streptococcal structures. i. re-evaluation of hla cytotoxicity inhibition. | a number of experiments have suggested that there is an antigenic relationship between the hla complex and streptococcal bacterial structures. using inhibition of cytotoxicity of hla antisera as our assay system, it was demonstrated that the inhibitory effect on hla cytotoxicity by streptococcal antigens is, in reality, due to activation and consumption of components of the alternate complement pathway. in addition, antisera prepared against streptococcal membrane antigens had no cytotoxic effec ... | 1976 | 818334 |
| nonspecific complement activation by streptococcal structures. ii. properdin-independent initiation of the alternate pathway. | complement consumption by isolated membranes and walls from group a streptococci and various other gram-positive microbes has been tested. these microbial structures were found to activate the alternate complement pathway. however, unlike endotoxin, inulin, or other plant polysaccharides, activation of complement by our material was found to bypass properdin. the activating factor(s) also differs from cobra venom in its/their requirement for factor d. preliminary experiments suggest this factor ... | 1976 | 818335 |
| quantitative structure-activity relationships. 2. a mixed approach, based on hansch and free-wilson analysis. | based on the theoretical and numerical equivalence of hansch's linear multiple regression model and the modified free-wilson model a mixed approach is developed. the mixed approach is a combination of both models which makes use of the advantages of each model and widens the applicability of hansch and free-wilson analysis. the free-wilson approach now is applicable also in the case of parabolic dependence of biological activity on a particular physical property, e.g., log p or pi. a rational ex ... | 1976 | 818381 |
| plasmid-determined tetracycline resistance in streptococcus faecalis: tandemly repeated resistance determinants in amplified forms of pamalpha1 dna. | | 1976 | 818395 |
| bacterial endocarditis in pregnancy: successful surgical correction. | bacterial endocarditis, an extremely rare and serious complication during pregnancy, is almost always fatal to the fetus. this paper describes successful aortic valve replacement in a woman who was 22 weeks' pregnant. she had acute bacterial endocarditis with aortic insufficiency and severe congestive heart failure. at term, she was delivered of a live infant. we believe this is the first case of a fetus surviving such a complication. | 1976 | 818452 |
| [energy-dependent accumulation of an artificial dibenzyldimethylammonium cation by gamma-irradiated cells]. | | 1976 | 818676 |
| [fecal streptococci as indicators of fecal water contamination. i. quantitative comparison of the occurrence of coliform bacteria and streptococcus faecalis in human feces]. | | 1976 | 818697 |
| route of infection in extrahepatic biliary tract disease. i: experimental evidence against an entero-hepatico-biliary cycle of bacteria. | e. coli and strep. faecalis inoculated intravenously in normal rabbits produced initial concentrations of 10(6) bacteria per ml blood. culture of common duct bile collected continously via a catheter in the common duct, and of gallbladder bile aspirated by puncture, failed to demonstrate a passage of bacteria from blood to bile. sterile common duct bile and gallbladder bile in the presence of high counts of viable bacteria in blood, gallbladder wall and liver tissue demonstrated that the intact ... | 1976 | 818701 |
| evaluation of pfizer selective enterococcus and kf media for recovery of fecal streptococci from water by membrane filtration. | pfizer selective enterococcus (pse) and kf agars were compared for their recovery of fecal streptococci from sewage effluent on membrane filters. the results showed that pse agar is highly selective for the enterococci. the tan color resulting from esculin hydrolysis, which was not always visible on the surfaces of the colonies, is not considered a necessary differential characteristic on pse agar since more than 90% of all colonies recovered on membrane filters were confirmed as fecal streptoco ... | 1976 | 818956 |
| concentrations of nitrifying bacteria in sewages, effluents, and a receiving stream and resistance of these organisms to chlorination. | estimates of nh4+-and no2-oxidizers in samples from four activated sludge plants treating mainly domestic sewage were obtained using a most-probable-number (mpn) technique. ranges of concentrations per milliliter of each, respectively, were 1,010 to 3,880 and 79 to 145 in settled sewages, 32 to 7,420 and 2 to 1,010 in secondary effluents, and less than 0.1 to 622 and 0.1 to 70 in chlorinated secondary effluents. the results of this field study indicated that nitrifiers were more resistant to chl ... | 1976 | 818958 |