| in vitro synthesis of peptidoglycan by beta-lactam-sensitive and -resistant strains of neisseria gonorrhoeae: effects of beta-lactam and other antibiotics. | the synthesis in vitro of peptidoglycan by neisseria gonorrhoeae was studied in organisms made permeable to nucleotide precursors by treatment with ether. optimum synthesis occurred at 30 degrees c in tris(hydroxymethyl)aminomethane-maleate buffer (0.05 m; ph 6) in the presence of 20 mm mg(2+). the incorporation from uridine 5'-diphosphate-n-acetyl-[(14)c]glucosamine into peptidoglycan, measured after precipitation of the cells with trichloroacetic acid, was sensitive to the beta-lactam antibiot ... | 1979 | 112918 |
| evaluation of the antiserum agar method for the serogroup identification of neisseria meningitidis. | the antiserum agar method (asa), which is based on the formation of immunoprecipitates around bacterial growth on agar containing meningococcal hyperimmune horse serum, was evaluated for serogroup identification of neisseria meningitidis. four hundred meningococcal stains were serogrouped by asa employing horse antisera to serogroups a, b, c, y, w135, z, and 29e and compared to serogroup identification by bacterial slide agglutination (ba) employing rabbit antisera. overall, there was 95% agreem ... | 1979 | 113070 |
| the biology of the gonococcus. | gonorrhea has been known since antiquity. today, this disease is the most commonly reported infectious disease in the u.s. the natural environment of the etiological agent, neisseria gonorrhoeae, is man. in this host, the organism usually parasitizes mucosal surfaces populated by columnar epithelial cells. under certain conditions, the gonococcus may disseminate or spread to adjacent organs. the gonococcus is well adapted to its environment and is a successful parasite. until recently, gonococci ... | 1978 | 113174 |
| antibiotic resistance in h. influenzae and n. gonorrhoeae. | | 1979 | 113335 |
| culturing for isolation of neisseria gonorrhea. | | 1979 | 113481 |
| neisseria meningitidis. probable pathogen in two related cases of urethritis, epididymitis, and acute pelvic inflammatory disease. | | 1979 | 113569 |
| neisseria meningitidis urethritis. a case report. | | 1979 | 113570 |
| plaque assay for measuring serum bactericidal activity against gonococci. | a new semiquantitative plaque assay was developed to measure killing of gonococci by serum. results compare well with an established quantitative method, but the plaque assay is faster, simpler, and less expensive. | 1978 | 103891 |
| [auxotypes and sensitivity to 6 antibiotics of strains of neisseria gonorrhoeae isolated at strasbourg in 1977-1978 (author's transl)]. | we have studied 386 strains of neisseria gonorrhoeae isolated in our laboratory from july 1977 to october 1978, with the catlin's auxotyping method. the distribution of the four main auxotypes, i. e. (+), (pro-), (arg-), (arg-, hyx-, ura-), is different from those reported by others (in u. s. a. and sweden). in strasbourg, the auxotype (+) is prevalent. we have noticed some differences among classes of population. for example (arg-) and (arg-, hyx-, ura-) are scarcely isolated from prostitutes a ... | 1979 | 114090 |
| comparative immunogenicity of vaccines prepared from capsular polysaccharides of group c neisseria meningitidis o-acetyl-positive and o-acetyl-negative variants and escherichia coli k92 in adult volunteers. | three structurally and antigenically similar capsular polysaccharides, two derived from group c neisseria meningitidis (o-acetyl-positive and o-acetyl-negative variants) and one from escherichia coli k92, which cross-reacts with polysaccharide from group c n. meningitidis, were compared for their ability to induce anticapsular and bactericidal antibodies to group c n. meningitidis in adult volunteers. all three vaccines elicited group c-specific serum antibodies. the vaccine derived from the o-a ... | 1979 | 108338 |
| studies of ciliated epithelia of the human genital tract. 3: mucociliary wave activity in organ cultures of human fallopian tubes challenged with neisseria gonorrhoeae and gonococcal endotoxin. | quantative determinations of the mucociliary activity of human fallopian tube epithelium maintained as organ cultures were performed using a light beam reflex method. in non-infected organ cultures the mucociliary wave (mcw) frequency slowly decreased during the first 54 hours of culture maintenance. in organ cultures experimentally infected with fresh isolates of neisseria gonorrhoeae producing t1/t2 colonies the mcw frequency either decreased to subnormal values or completely ceased whereas in ... | 1979 | 114195 |
| studies on gonococcus infection. xvii. iga1-cleaving protease in vaginal washings from women with gonorrhea. | vaginal washings from women attending a veneral disease clinic were examined for the presence of protease that cleaved iga subclass 1 (iga1). in a crude assay, vaginal washings cleaved [125i]iga1 in 19 of 25 specimens from individuals from whom neisseria gonorrhoeae were cultivated. forty-six specimens from 104 women whose cultures were negative for n. gonorrhoeae also cleaved [125i]iga1. vaginal washings from six of six women with culture-proven gonorrhea cleaved [125i]iga1 into low-molecular-w ... | 1979 | 108339 |
| meningococcal conjunctivitis. | meningococcal conjunctivitis is typically described as an acute purulent infection. an atypical case of mild catarrhal conjunctivitis occurred in a 19-year-old college student. the meningococci were identified as neisseria meningitidis, group a, and were isolated from the throats of the patient and her roommate. the conjunctivitis responded rapidly to treatment with sodium sulfacetamide, and it was not treated systemically. a short review of the literature of meningococcal conjunctivitis is pres ... | 1979 | 109067 |
| sensitivity of neisseria gonorrhoeae to penicillin in west germany. | the sensitivity of gonococci to penicillin in germany has largely decreased in the last 22 years. no significant decrease has occurred, however, in the last three years, but the results show that a slight tendency to decrease may be persisting. | 1979 | 109164 |
| do contraceptives influence the incidence of acute pelvic inflammatory disease in women with gonorrhoea? | the influence of different contraceptive techniques on the incidence of pelvic inflammatory disease (pid) in 672 patients with gonorrhoea have been studied. the lowest frequency of pid was found in patients using hormonal contraceptives (group a), 8.8 per cent compared to 23.5 per cent in patients using intrauterine devices (group b) and 15.1 per cent in patients using neither technique (group c). in comparable control groups no significant differences in background factors, such as age, marital ... | 1979 | 114354 |
| antigenic polypeptide complex from the melvin strain of neisseria gonorrhoeae: isolation and properties. | an antigenic complex has been isolated in a highly purified from from the melvin strain of neisseria gonorrhoeae. the complex has a molecular weight of 9.3 x 10(6) and on sodium dodecyl sulfate-polyacrylamide gel electrophoresis was found to consist of several subunits; the most predominant had the following molecular weights: 110,000, 94,000, 68,000, a smear containing (52,000, 48,000, and 44,000), 42,000, 36,000, 29,000, 28,000, 26,000, and 12,000 comprising 89% of the total protein. with the ... | 1979 | 114490 |
| preservation of neisseria gonorrhoeae by the gelatin-disc method. | studies of neisseria gonorrhoeae are difficult to perform because of the organism's poor survival in vitro. to solve this problem we tried to preserve the organism by a gelatin-disc method. the rate of survival and changes of variations in some biochemical properties of eight strains of n. gonorrhoeae were followed for three years. these studies proved that preservation was satisfactory with only a 1/10 reduction of the living cells. another trial showed that the organism survived for over six m ... | 1979 | 109165 |
| rapid serogroup identification of neisseria meningitidis by using antiserum agar: prevalence of serotypes in a disease-free military population. | nasopharyngeal cultures from 414 marines were plated directly onto antiserum agar containing the antibiotics vancomycin, colistin, and nystatin for meningococcal isolation and serogroup identification. meningococci were isolated from 267 marines, giving a carrier prevalence of 64.5%. a total of 58% of the isolates could be placed into serogroups; of these 22.3% were group b, 4.7% were group c, 25.7% were group y, 24.3% were group w135, and 23.0% were group 29e. no serogroup a organisms were reco ... | 1979 | 114532 |
| the diagnosis of gonorrhoea in women. | gonorrhoea was diagnosed in 258 of 1500 women. the diagnosis was made from urethral plus cervical cultures in only 184 cases (71.3%). the percentage of positive diagnoses rose to 96.5% when cervical smear microscopy was also performed. this highlights the need to carry out all three investigations. concurrent trichomonas infection was present in 14% of cases. | 1979 | 114741 |
| [the first isolation in france of a strain of neisseria gonorrhoeae producing penicillinase]. | | 1979 | 114977 |
| [identification of neisseria gonorrhoea in cultures on various solid media by means of immunofluorescence technic]. | | 1979 | 115064 |
| orogenital contact and the isolation of neisseria gonorrhoeae, mycoplasma hominis, and ureaplasma urealyticum from the pharynx. | men and women who came to clinics in boston underwent pharyngeal examinations, and pharyngeal specimens were obtained for cultures for neisseria gonorrhoeae, mycoplasma hominis, and ureaplasma urealyticum. fifty-one (4.9%) of 1,037 participants had gonococcal pharyngeal infection. m. hominis and u. urealyticum were recovered from the pharynges of 149 (14.3%) and 154 (14.8%) of 1,044 participants, respectively. the history of ever having performed fellatio was associated with pharyngeal infection ... | 1979 | 115097 |
| treatment of gonorrhea: what effect will antibiotic resistance have in the future? | | 1979 | 115098 |
| complex of meningococcal group b polysaccharide and type 2 outer membrane protein immunogenic in man. | a noncovalent complex of meningococcal group b polysaccharide and type 2 outer membrane protein has been characterized and its potential as a vaccine against group b meningococcal disease investigated. the polysaccharide component was found to have a partition coefficient, k(d), of 0.34 on sepharose cl-4b in the presence of sodium deoxycholate. the protein consisted of four to five major proteins including the principal outer membrane protein. hydrophobic binding between the protein and polysacc ... | 1979 | 109466 |
| antibody-dependent cell-mediated antibacterial activity of human mononuclear cells. i. k lymphocytes and monocytes are effective against meningococi in cooperation with human imune sera. | in cooperation with human heat-inactivated antisera from adults immunized with group c meningococcal polysaccharide, normal human peripheral blood mononuclear cells significantly decreased the viability of group c meningococci (mgc) in vitro. k lymphocytes (null cells) and monocytes, (but not t or b lymphocytes) were capable of effecting antibody-dependent cell-mediated (adc) antibacterial activity in this system. the degree to which meningococcal viability was decreased was a function of the le ... | 1979 | 109572 |
| in vitro activity of rosamicin, josamycin, erythromycin, and clindamycin against beta-lactamase-nagative and beta-lactamase-positive strains of neisseria gonorrhoeae. | randomly selected strains of beta-lactamase-negative and beta-lactamase-positive neisseria gonorrhoeae were tested by an agar dilution method for susceptibility to rosamicin, josamycin, erythromycin, clindamycin, and penicillin g. rosamicin was more active than erythromycin, which was more active than josamycin or clindamycin; the latter two were similar in their activity. the susceptibility to the macrolide antibiotics and clindamycin was independent of beta-lactamase production, but the penici ... | 1979 | 106776 |
| [occurrence of gonococci with reduced sensitivity in samples tested at the county hospital in dresden between 1975 and 1977]. | | 1979 | 115163 |
| [gonorrhoea - diagnosis and therapy over the last century (author's transl)]. | | 1979 | 115177 |
| [evaluation of the role of specific antimeningococcal antibodies in the spread of meningococcal carrier states in collectives]. | the results of serological, bacteriological and epidemiological studies carried out in populations with different epidemic pattern of meningococcal infection are presented. a-group specific antibody was found to have the leading role in the intensity of the spread of meningococcal infection in the populations. the presence of antibody to this antigen in 16.7% of serum samples inhibited dissemination of meningococci in the populations. simultaneously with an increase in the herd immunity level to ... | 1979 | 115184 |
| [immunologic characteristics of the protein antigens of the neisseriaceae family. i. antigenic interrelationships between nonpathogenic representatives of the genus neisseria]. | the immunological characteristics of protein complexes isolated from the filtrates of broth cultures, obtained after prolonged incubation, of 86 strains of n. perflava, n. flava, n. subflava, n. flaviscens, n. sica and n. mucosa are presented. all these strains, irrespective of their species, had 11--15 common antigens and differed by 1--4 components. the presence of common antigens in all representatives of the family neisseriaceae has been proved to be important for the study of immunological ... | 1979 | 115187 |
| neisseria gonorrhoeae: physiology and metabolism. | | 1979 | 109930 |
| [detection of healthy carriers of neisseria meningitidis in a sample of the population of the city of messina]. | | 1977 | 106778 |
| meningococcal colonization and infection in children and their household contacts. | a bacteriologic survey was performed to estimate the prevalence and duration of meningococcal carriage in children in montreal, canada. infants and children with proven meningococcal infection, or with asymptomatic meningococcal nasopharyngeal (np) carriage, and their household contacts, were also studied to define communicability. n. meningitidis was present in 30 (2.4%) of the np cultures from 1238 asymptomatic infants and children in this civilian population during a non-epidemic period. meni ... | 1979 | 110143 |
| investigation of females for gonorrhoea. | | 1978 | 110479 |
| studies on gonococcus infection. xviii. 125i-labeled peptide mapping of the major protein of the gonococcal cell wall outer membrane. | the major outer membrane proteins from 10 gonococcal strains were examined after 125i-labeling of the proteins as single bands resolved by polyacrylamide gel electrophoresis in sodium dodecyl sulfate. these 125i-proteins were then treated with either trypsin or alpha-chymotrypsin, and the resultant 125i-peptides were visualized by autoradiography after two-dimensional electrophoretic and chromatographic separation on thin-layer cellulose sheets. several 125i-peptides were present in all the majo ... | 1979 | 110681 |
| individual susceptibility to neisserial infection? | specimens from genital, anorectal, and pharyngeal sites from 1671 men and 1419 women were cultured for neisseria gonorrhoeae. pharyngeal specimens were also cultured for neisseria meningitidis, n. gonnorrhoeae was isolated from a genital site 2.7 times more often in men and 1.8 times more in women who also carried meningococci in their pharynx than from those who did not; the meningococcus was isolated 3.4 times more often from men and 2.0 times more often from women with genital gonorrhoea than ... | 1979 | 111765 |
| protection against group b meningococcal disease: evaluation of serotype 2 protein vaccines in a mouse bacteremia model. | a mouse bacteremia model was used to evaluate the immunogenicity and protection against challenge provided by five different meningococcal serotype 2 vaccines. mice vaccinated with serotype 2 protein vaccines had levels of bacteremia reduced by at least 100-fold after challenge with group b serotype 2 miningococci. mice vaccinated with serotype 2 protein vaccine and challenged with group c serotype 2 meningococci showed 10-fold or less reduction in bacteremia. vaccines were primarily serotype sp ... | 1979 | 115794 |
| effects of low ampicillin concentrations on penicillin sensitive and beta-lactamase producing strains of neisseria gonorrhoeae. | the effects of therapeutic concentrations of ampicillin on non-beta-lactamase and beta-lactamase producing strains of neisseria gonorrhoeae were studied. a small but significant fraction of bacteria in a gonococcal population was found to respond in a bacteriostatic rather than a bactericidal way upon ampicillin treatment. in agreement with this was the finding of morphologically unaltered cells in the scanning electron microscope after ampicillin exposure. ampicillin treatment of beta-lactamase ... | 1979 | 115831 |
| a pharmacological and in vitro comparison of three oral cephalosporins. | the pharmacology of cephradine, cephalexin and a new oral cephalosporin, cefaclor, has been compared in six volunteers. cefaclor was absorbed rapidly and was cleared from the serum more rapidly than the other two agents. this was probably partially due to its instability in serum at body temperature, which was investigated. against a wide range of common pathogens cefaclor was the more active oral cephalosporin. in particular the activity against neisseria gonorrhoeae and haemophilus influenzae ... | 1979 | 115833 |
| in vitro susceptibility of penicillianse-producing neisseria gonorrhoeae to a select group of antimicrobial agents, alone and in combination. | | 1979 | 115835 |
| cotransformation of temperature sensitivity and nutritional markers in neisseria gonorrhoeae. | cotransformation remains the only tool for establishing linkage in neisseria gonorrhoeae. because of the difficulty of inducing auxotrophic markers via mutagenesis in this species, most previous studies have utilized antibiotic resistance and naturally occurring (auxotypic) auxotrophic markers. we have succeeded in isolating auxotrophic and temperature-sensitive mutants. the temperature-sensitive mutants have been characterized by their growth on complex and defined media at 31, 37, and 40 degre ... | 1979 | 115839 |
| urethritis attributable to neisseria meningitidis, group x: a case report. | neisseria meningitidis, group x, was recovered from the anterior urethra of a 27-year-old male patient with urethritis. this isolate represents the first reported recovery of this organism from this anatomic site in association with this disease. he was treated with probenicid by mouth, followed by 4.8 million units of aqueous procaine penicillin g injected intramuscularly and became asymptomatic in three days. his recovery strongly indicates that the meningococcus was the etiologic agent of the ... | 1979 | 116007 |
| mezlocillin in the treatment of gonorrhoea. | a single, intramuscular dose of 2 g of mezlocillin was used for the treatment of 158 patients with gonorrhoea. in only three out of 144 patients with urogential gonorrhoea who were re-examined did the treatment fail. of 12 patients with pharyngeal gonorrhoea who were examined after treatment 10 were treated successfully with the same dose. the sensitivities of the gonococci to mezlocillin and penicillin g correlated well, although mezlocillin seemed to be active at lower concentrations on both h ... | 1979 | 111766 |
| successful treatment with cefaclor of gonococcal urethritis in men. | cefaclor, a new orally administered cephalosporin, was evaluated by a randomized trial for effectiveness in the treatment of uncomplicated urethritis due to neisseria gonorrhoeae in men. regimens included 2,3, and 4 g of cefaclor, with or without 1 g of orally administered probenecid, as single daily doses for three days. the diagnoses were confirmed by isolation of n. gonorrhoeae; cures or therapeutic failures were determined by follow-up cultures on day 7 after completion of therapy. sixty-six ... | 1979 | 116373 |
| evaluation of five serologic tests for antibody to neisseria gonorrhoeae. | sera from 1,167 individuals were tested for antibody to neisseria gonorrhoeae by use of five different serologic tests. these were complement fixation, the indirect fluorescent antibody test, gonosticon dri-dot, fluorescent gonorrhea test-heated, and gonorrhea screen test. parallel cultures of material from the throat, urethra, cervix, and rectum were also done. the results were analyzed by a technique intended to separate test effects from population effects. test specificities ranged from 81.3 ... | 1979 | 116374 |
| the etiology and pathogenesis of pelvic inflammatory disease. | | 1979 | 116375 |
| the etiology of acute pelvic inflammatory disease. | | 1979 | 116376 |
| [characteristics of cellular and humoral factors of immunity in chronic gonorrhea in the process of treatment]. | | 1979 | 116432 |
| [antibioprophylaxis of meningococcal meningitis: reality or utopia? (author's transl)]. | after restating the activity of the various antibiotics on neisseria meningitidis, the authors review the results of 18 experiences of germ-carriers control by antibiotics, which were rather deceiving. conditions for such a control are exposed but question of its real necessity is raised. | 1978 | 106213 |
| [antimeningococcal antibodies in healthy mothers and their newborn (author's transl)]. | blood specimen from 180 healthy mothers and their newborn were obtained during the delivery for the evaluation of placental transfer of anti-a, anti-b and anti-c antimeningococcal antibodies. the detection of titration of antibodies were performed by passive haemagglutination. anti-a antibodies were found in 22%, anti-b in 64%, and anti-c in 30% of the mothers. in the newborns the corresponding proportions were 4.5%, 50% and 28%. for anti-a and anti-b antibodies a moderate positive correlation w ... | 1979 | 116588 |
| comparison of the penicillin-binding proteins of different strains of neisseria gonorrhoeae. | this study was undertaken to determine if the categorization of neisseria gonorrhoeae strains into disseminated gonococcal infection (dgi) and non-dgi types was also paralleled by some common characteristic in their penicillin-binding proteins (pbps). fluorography of sodium dodecyl sulfate-containing polyacrylamide gels, on which the [14c]penicillin-labeled pbps had been separated, was used to visualize the pbps. no common characteristic pbp for genital or dgi strains was observed. apart from pb ... | 1979 | 116593 |
| chlamydia trachomatis in acute salpingitis. | in a study to evaluate the possible role of chlamydia trachomatis and neisseria gonorrhoeae in acute salpingitis, 26% of 106 patients with severe symptoms had positive culture results for c. trachomatis; 43% of the 72 patients from whom paired sera were obtained had either positive culture results for or seroconversion in the single antigen immunofluorescence test to c. trachomatis. twenty-six per cent of patients harboured n. gohorrhoeae and 14% had gonococcal complement-fixing antibody titres ... | 1979 | 111767 |
| purification by affinity chromatography and properties of a beta-lactamase isolated from neisseria gonorrhoeae. | beta-lactamase activity was detected in cell-free preparations obtained from ultrasonic treatment of neisseria gonorrhoeae after growth in liquid medium. crude preparations of beta-lactamase were subjected to affinity chromatography, using several beta-lactam antibiotics as ligands bound to agarose supports. affinity gels produced by coupling 7-aminocephalosporanic acid or 6-aminopenicillanic acid by their amino groups to carboxyl-terminal agarose via a five- to eight-carbon spacer arm proved to ... | 1979 | 106775 |
| [presence of anti-neisseria meningitidis antibodies in the normal population of messina]. | | 1977 | 106779 |
| gonococcal interactions with polymorphonuclear neutrophils: importance of the phagosome for bactericidal activity. | gonococci are capable of attaching to the surface of polymorphonuclear leukocytes (pmn). in this location they resist phagocytosis and are not killed by pmn. to delineate the factors involved in the survival of these gonococci, we investigated the interaction of virulent gonococci, which adhere to cells and resist phagocytosis, and avirulent gonococci, which are phagocytized and killed by pmn. in the presence of serum, both virulent and avirulent gonococci associate equally well with pmn and sti ... | 1978 | 107196 |
| differences in attachment antigens of gonococci in reinfection. | on the basis of bacterial typing, pyocin typing, and antibiotic sensitivity tests, two consorts appeared to have been reinfected 34 and 41 days later, respectively, with the same gonococcal strain, suggesting a failure in these patients to develop effective immunity to reinfection. however, these tests do not measure antigens which mediate attachment, a function which may correlate with virulence. when the above infecting strains were retested in an inhibition-of-attachment assay using rabbit go ... | 1979 | 107257 |
| [simultaneous detection of pili and capsules on neisseria gonorrhoeae by means of the electron microscope (author's transl)]. | | 1979 | 111975 |
| pseudogonococcal ophthalmia neonatorum. branhamella (neisseria) catarrhalis conjunctivitis. | a culture from conjunctivitis occurring in a neonate in association with a recurrent fever yielded a nearly pure growth of branhamella (neisseria) catarrhalis. the conjunctivitis was not appreciated and effectively treated until a second hospitalization in the fourth week of life. partial suppression of symptoms had followed short-term parenteral antibiotic therapy during the first admission. resolution quickly occurred in response to instillation of sodium sulfacetamide ophthalmic solution. alt ... | 1979 | 112856 |
| secretory antibody response of the cervix to infection with neisseria gonorrhoeae. | cervical secretions from 157 women were examined for antibody against neisseria gonorrhoeae by an indirect immunofluorescent antibody test. antigonococcal antibody was detected in 73 (97%) of 75 infected women, being of the igg class in 73 (97%), of the iga class in 71 (95%), and of the igm class in 29 (39%). igm antibody was nearly always associated with infections of less than 15 days' duration. immunoglobulin g, reactive with n. gonorrhoeae, was found in 23 (33%) of 70 non-infected women; of ... | 1979 | 114196 |
| evaluation of urethral culture for neisseria gonorrhoeae in the routine investigation of men attending a std clinic. | urethral gonorrhoea was diagnosed by culture in 957 (18.8%) of 5076 new male patients attending a sexually transmitted diseases clinic; the infection was asymptomatic in 38 (4%) of these patients. the diagnosis in only six (0.3%) out of 2159 men with urethral gonorrhoea but with no symptoms or signs of urethritis would have been missed if urethral cultures had not been performed. | 1979 | 114197 |
| the intracellular survival and growth of gonococci in human phagocytes. | in reassessment of previous tests for intracellular survival, results have been confirmed and additional evidence obtained indicating that some gonococci can survive and multiply in human phagocytes. use was made of the ability of penicillin to penetrate phagocytes and to kill only actively growing organisms. in microscopic counts on 33 urethral exudate smears, an average of 49% of gonococci were associated with polymorphonuclear phagocytes. the organisms were unevenly distributed amongst the ph ... | 1979 | 117078 |
| modern trends in the laboratory diagnosis of gonorrhoea. | | 1979 | 117273 |
| [the centenary of the gonococcus: the importance of its discovery and the acknowledgement of this in the netherlands (ludwig sigesmund albert neisser)]. | | 1979 | 117386 |
| the in vitro and in vivo effects of a surgical lubricant on the recovery of gonococci from the endocervical canal. | a surgical lubricant containing phenylmercuric borate, tested in vitro, was shown to alter the recovery of the gonococcus. in vivo studies of 150 patients, 60 (40%) of whom were infected with neisseria gonorrhoeae, were performed to determine if examination with the surgical lubricant, as compared to tap water, altered the ability to recover n. gonorrhoeae from the cervix. results indicated that although the surgical lubricant containing phenylmercuric borate was bacteriostatic in vitro, it did ... | 1979 | 117411 |
| [in vitro susceptibility of n. gonorrheae to five penicilins (author's transl)]. | | 1979 | 117539 |
| analysis of a bivalent meningococcal vaccine (a + c). part i. analytical and safety data. | | 1979 | 117760 |
| analysis of a bivalent meningococcal vaccine (a + c). part ii. stability. | | 1979 | 117761 |
| auxanographic grouping and typing of neisseria gonorrhoeae. | nearly 96% of 1297 neisseria gonorrhoeae isolates in hamilton were assigned to six major auxanographic groups (non-requiring or nr, pro-, orn-, pro-cit-ura-, orn-ura-hyx-, cit-ura-hyx-) as established by requirements for none, or any one or more of proline, uracil, hypoxanthine, citrulline (cit-), or citrulline replaceable by ornithine (orn-) on chemically defined medium modified from catlin (1973). seven other groups, and strains not growing, accounted for 4.2%. the most common groups were orn- ... | 1979 | 114295 |
| disseminated gonococcal infections (dgi). | neisseria gonorrhoeae infects superficial membranes of the eyes, oropharynx, genital tract, and rectum prior to dissemination. gonococcal isolates cultured from patients with disseminated gonococcal infections (dgi) show resistance to serum bacteriolysis, are very sensitive to penicillin, and have characteristic growth requirements for certain amino acids. dgi is characterized by recurrent chills and fever, polyarthralgias and/or polyarthritis (with effusions), and skin lesions. the skin manifes ... | 1979 | 117979 |
| simultaneous scabies and gonococcal infection. | a case is presented of an unusual complication arising in a man with scabies and gonococcal urethritis: the secondary infection of excoriated genital lesions by neisseria gonorrhoeae. this occurred after he had occluded his genitals with a plastic wrap. | 1979 | 117980 |
| comparison of a slide coagglutination technique with the minitek system for confirmation of neisseria gonorrhoeae. | the phadebact gonococcus test was performed on 314 bacterial isolates to compare the coagglutination technique with the minitek system for the confirmation of neisseria gonorrhoeae. direct testing, using colonies of n. gonorrhoeae mixed with the phadebact gonococcus test reagents, produced noninterpretable results in many cases. however, an alternative method, described by the manufacturer, of heating several colonies in distilled water for 20 min before testing alleviated most interpretation d ... | 1979 | 114531 |
| clinical forms of meningococcal arthritis: a study of five cases. | five cases of meningococcal arthritis are described. two clinical forms were observed: an early-onset acute polyarthritis (type i) and a late-onset subacute monoarthritis (type ii). the 2 clinical subsets may represent sequential stages, an early bacteremic and a late stage of joint localization. to improve patient classification, diagnostic criteria are proposed. | 1979 | 118256 |
| penicillin resistant gonorrhea. | | 1979 | 118305 |
| penincillin-resistant gonorrhoea. a report from university hospital, kuala lumpur. | | 1979 | 118322 |
| [acute meningo-encephalitis in adolescents and adults--i. germs, rate of morbidity and lethality (author's transl)]. | diverse forms of acute meningo-encephalitis found in adolescents and adults are discussed considering 1244 cases treated at the neurologic clinic of the university at cologne in the time from 1950 till 1975. the rate of morbidity and lethality was found to vary according to the type of causative germ. the inflammation often took another course than in childhood. the age at the outbreak of the disease, infection immunity, precursing and concomitant illnesses as well as the onset of medication inf ... | 1979 | 118326 |
| management of gonococcal pelvic inflammatory disease. | information that has become available since 1974 on the management of pelvic infections unrelated to abortions, the puerperium, or pelvic surgery, with an emphasis on those associated with neisseria gonorrhoeae are summaried. attention is directed to both diagnosis (clinical, bacteriologic) and therapy (hospitalized patients, outpatients, indications for hospitalization, and iuds). most investigators classify acute pelvic inflammatory disease (pid) as gonococcal or nongonococcal on the basis o ... | 1979 | 115099 |
| [1st cases of gonorrhea caused by penicillinase-producing neisseria gonorrhoeae in poland]. | | 1979 | 118491 |
| [results of examinations of gynecologic patients for gonorrhea]. | | 1979 | 118492 |
| [studies on the effectiveness of cephalosporins against neisseria gonorrhoeae]. | | 1979 | 118493 |
| the prevalence of group b streptococci in human urogenital secretions. | urogenital secretions from a total of 510 patients (153 female and 151 male venereological patients, 123 gynaecological patients and 83 gynaecologically normal women) have been examined for group b streptococci (b-str.) and gonococci. the prevalence of b-str. (32%) among the female venereological patients was significantly higher than among the gynaecological patients (21.1%) and normal women (18.0%). urethral samples gave a higher recovery rate of b-str. than cervical samples. a significant cor ... | 1979 | 118523 |
| [effect of nitroimidazole therapy on the demonstration of gonococci]. | the minimal inhibitory concentration of metronidazole and tinidazole lies between 4000 micrograms/ml and 7.8 micrograms/ml. drug levels are present in this range for 2--5 hours in genital discharge following single dose oral therapy with 2 g tinidazole or 1.5 g metronidazole. therefore, 5-nitroimidazole derivatives exert a bacteriostatic effect in the genital region at least on the more sensitive strains. as shown in our experiments, otherwise reliable laboratory procedures for the demonstration ... | 1979 | 118597 |
| reverse passive haemagglutination test for the rapid identification of neisseria gonorrhoeae and detection of penicillinase production. | in a comparison of the reverse passive haemagglutination test (rpha) with the direct immunofluorescent and rapid carbohydrate utilisation tests for the identification of neisseria gonorrhoeae isolated from clinical specimens, 315 isolates of oxidase-positive gram-negative diplococci were tested as pure 24-hour-old subcultures and samples from 108 similar organisms were taken directly from primary isolation plates. a similar test system was used to detect penicillinase production. results showed ... | 1979 | 118798 |
| treatment of disseminated gonococcal infections. | | 1979 | 115100 |
| ophthalmia neonatorum due to neisseria gonorrhoeae: prevention and treatment. | | 1979 | 115101 |
| experimental infection of the genital tract of female grivet monkeys by mycoplasma hominis: effects of different routes of infection. | in a previous study we produced acute salpingitis and parametritis in grivet monkeys by inoculation of mycoplasma hominis directly into the uterine tubes. with the purpose of examining in the same animal model the effect of more natural routes of infection, six female grivet monkeys were inoculated, two by two, with m. hominis by the following methods: (experiment a) into the uterine cavity through the cervical canal; (experiment b) into the uterine cavity by the same route, but after ligature o ... | 1979 | 118928 |
| serological grouping of meningococci and encapsulated haemophilus influenzae strains by latex agglutination. | the latex agglutination method, utilizing antibody-coated latex particles, was adapted for serogrouping of neisseria meningitidis and serotyping of encapsulated haemophilus influenzae strains from agar plates. it was found to give more clear-cut results than conventional slide agglutination. a 100% agreement with the antiserum agar method was found for all strains isolated from blood or cerebrospinal fluid. many meningococcal strains from nasopharyngeal carriers are autoagglutinable, but some of ... | 1979 | 118981 |
| kinetics of antibody production to group a and group c meningococcal polysaccharide vaccines administered during the first six years of life: prospects for routine immunization of infants and children. | a cohort of infants, previously immunized once or twice between three and 12 months of age with vaccines containing polysaccharide of groups a and c neisseria meningitidis, received boosters at two and five and one-half years of age with bivalent a/c vaccine. antibody concentrations were measured by a radioactive antigen-binding assay. concentrations of antibody to groups a and c n. meningitidis were 5.59 and 2.86 microgram/ml, respectively, by four years of age. after booster immunization at fi ... | 1979 | 118997 |
| the role of natural igg and complement in the phagocytosis of type 4 neisseria gonorrhoeae by human polymorphonuclear leukocytes. | the role of human serum components in the phagocytosis of logarithmic-phase type 4 neisseria gonorrhoeae by human polymorphononuclear leukocytes was investigated. the requirement of fresh normal human serum (fhs) for optimal phagocytosis and the fixation of human immunoglobulin (igg) and complenet (c3) to the gonococcal cell surface suggested that both serum factors participate in the phagocytosis of these organisms. the percentage of neutrophils containing ingested organisms was directly propor ... | 1979 | 118998 |
| the management of penicillin resistant gonococcal urethritis in northern nigeria. | forty-five men, with acute gonococcal urethritis, were treated with a single dose regime of probenecid 1 gm and procaine penicillin, 4.8 mega-units, yielding a cure in 97 per cent. multiple antibiotic resistance was noted in 69 per cent of 28 neisseria gonorrhoeae isolates, and of 19 isolates tested for precise penicillin sensitivity, 58 per cent were resistant to greater than 2 i.u./ml. serum penicillin levels measured in 3 patients showed adequate duration of plateau levels. the advantages of ... | 1979 | 119057 |
| oral manifestations of gonococcal infection. | | 1978 | 115304 |
| cefoxitin in the treatment of gonorrhea. | cefoxitin is active in vitro against beta-lactamase-producing strains of neisseria gonorrhoeae; therefore, its efficacy in the treatment of uncomplicated genital gonorrhea was evaluated in a study of ten men and 15 women. cefoxitin was administered in two intramuscular doses given 5 hr apart, patients alternately receiving either 1 g or 2 g of cefoxitin in each injection. probenecid (1 g) was administered orally with both injections to five women, and with the first injection only in the remaini ... | 1979 | 119328 |
| evaluation of a culture procedure for identification of neisseria gonorrhoeae. | a new rapid culture technique (microcult gc) for identification of neisseria gonorrhoeae was compared with a standard culture procedure in 151 patients (59 males, 92 females) suffering from urethritis and/or cervicitis. in 86.8% of the patients identical results were achieved when the new and the standard culture techniques were compared. in 4% the new culture technique revealed n. gonorrhoeae, confirmed by bram-stain microscopy, when the standard culture was negative. however in 9.1% the revers ... | 1979 | 115369 |
| outer membrane antigens of neisseria meningitidis group b serotype 2 studied by crossed immunoelectrophoresis. | this study shows that the capsular polysaccharide, protein, and lipopolysaccharide antigens from the outer membrane of neisseria meningitidis group b serotype 2 may be identified by crossed immunoelectrophoresis. by using this technique, seven precipitates were resolved when outer membrane preparations were reacted against goat anti-whole cell group b type 2 antiserum. most of these precipitates were identified by comparison with purified reference preparations. different outer membrane preparat ... | 1979 | 115791 |
| [clinical laboratory study of gonorrhea in women]. | | 1979 | 119364 |
| acute epididymitis: etiology and therapy. | fifty patients with acute epididymitis were evaluated prospectively by history, examination, and microbiologic studies, including cultures for aerobes, anaerobes, n. gonorrhoeae, chlamydia trachomatis, and ureaplasma urealyticum. e. coli was the predominant pathogen isolated from the urine of men over 35 years old and c. trachomatis and n. gonnorrheae were the predominant pathogens isolated from the urethra of men under 35. the etiologic role of e. coli and c. trachomatis was confirmed by isolat ... | 1979 | 119499 |
| male reproductive tract sequelae of gonococcal and nongonococcal urethritis. | gonorrhea is the most frequent bacterial infection as well as the most frequently reported venereal disease. nongonococcal urethritis has approximately the same incidence as acute gonorrhea in cases reported by many venereal disease clinics. the relative epidemiology of the two diseases, as well as their acute and chronic manifestations in the male genital tract (urethritis, prostatitis, and epididymitis), will be briefly discussed. resultant obstructions of the lower genitourinary tract of poss ... | 1979 | 119500 |
| culture methods for neisseria gonorrhoea. | cultures on an appropriate medium are both highly sensitive and specific, but false-negative cultures can occur because of sampling procedures, laboratory errors, sensitivity of certain gonococci to the vancomycin contained in selective mediums, or loss of bacterial viability in transport. | 1979 | 119501 |
| culture diagnosis of meningococcal carriers: yield from different sites and influence of storage in transport medium. | different specimens and techniques have been used in the diagnosis of carriers of neisseria meningitidis, reflecting the uncertainty about the optimal diagnostic procedure. in the present investigation the culture yield of meningococci from throat specimens was compared to that from nasopharyngeal speimens in 178 persons: 44 carriers were diagnosed. all of them were detected by culture of throat specimens while 34% of them would have remained undiagnosed if only nasopharyngeal specimens had been ... | 1979 | 119792 |
| comparison of two selective media in the cultural diagnosis of gonorrhoea. | a "chocolate" agar medium (ca-ncv) containing nystatin, colistin and vancomycin, was compared with the mnyc medium which contain lincomycin, colistin, amphotericin and trimethoprim. a total of 277 clinical specimens were cultured for gonococci, and 120 of these showed positive cultures on either or both of the media. the mnyc medium detected 96.6 per cent of the total number of positive cultures and 92.5 per cent of the patients and the ca-ncv medium after 80 and 79 per cent, respectively. nearl ... | 1979 | 120106 |
| variations in surface protein composition associated with virulence properties in opacity types of neisseria gonorrhoeae. | the biological properties of a series of opacity variants of neisseria gonorrhoeae p9 have been examined. a novel protein, designated protein iid* (mol. wt 28 850), was identified within the set of heat-modifiable surface proteins previously reported. all variants producing extra outer membrane proteins were less sensitive to the bactericidal action of serum than the prototype transparent strain, with protein iia* (mol. wt 28 500) being associated with increased resistance. the production of a d ... | 1979 | 120407 |