| fraction-specific populations of the hypervariable region of the hepatitis c virus in a patient with cryoglobulinemia. | nucleotide sequences of the hypervariable region (hvr) of the e2/ns1 gene of hepatitis c virus (hcv), which are now thought to contain epitopes for neutralizing antibodies, were compared between antibody-bound hcv and free hcv in a patient with type ii cryoglobulinemia. antibody-bound hcv was immunoprecipitated with anti-human immunoglobulins from serum of the patient. total rna was recovered from the pellet and the supernatant, respectively, and the envelope gene containing the hvr was amplifie ... | 1995 | 7595420 |
| non-a, non-b hepatitis unrelated to the hepatitis c virus (non-abc). | the history of non-abc hepatitis is a kaleidoscope of intriguing, but often conflicting and confounding data. studies of transfusion-associated non-abc hepatitis are less convincing than they originally seemed. chimpanzee cross-challenge studies, once the bastion for the theory of multiple nanb hepatitis agents, now have an alternative explanation in the impaired immune response associated with hcv infection and the ability of this agent to reinfect individuals previously assumed to be immune. n ... | 1995 | 7597441 |
| role of liver transplantation in viral hepatitis. | liver transplantation remains difficult in end-stage liver disease caused by chronic viral hepatitis because of recurrent viral infection in the liver graft. after transplantation for chronic hepatitis b virus (hbv), hepatitis c virus (hcv), and hepatitis delta virus (hdv) disease, recurrence is nearly universal. patients with actively replicating hbv infection before transplantation appear to be the most likely to experience clinically significant recurrent hepatitis, whereas recurrence in live ... | 1995 | 7602069 |
| vi international symposium on viral hepatitis: summary. | the vi international symposium on viral hepatitis was held in madrid, spain, 3-5 february 1994, under the chairmanship of dr vicente carreño. over 800 attended from more than 30 countries. considerable advances have been made since the fifth conference, which was held in 1992. these relate particularly to the role of hepatitis b virus (hbv) mutants and hepatitis c virus (hcv) genotypes and the prolonged assessment of interferon and its side-effects. the role of newer antiviral drugs alone or in ... | 1995 | 7602071 |
| the interaction between hepatitis b virus and hepatitis c virus in acute and chronic liver disease. | infections by the hepatitis b or c virus are extremely common causes of acute and chronic liver disease, and coexistence of the two viruses in the same patient is not rare. evidence has been found that such interaction may play an important role in fulminant hepatitis and in the development of hepatocellular carcinoma in cirrhotic patients. liver disease activity and prognosis have been reported to be generally more serious in the presence of double infection, although an inverse relationship in ... | 1995 | 7602074 |
| [a case of nephrotic syndrome mimicking membranoproliferative glomerulonephritis (mpgn) and associated with reactive hemophagocytic syndrome after renal death]. | we report a case of nephrotic syndrome which mimicked membranoproliferative glomerulonephritis (mpgn) and was associated with hemophagocytic syndrome after renal death. a 41-year-old japanese man was referred to our hospital because of nephrotic syndrome in february 1979. he had no signs, symptoms nor laboratory data suggestive of liver damage. he was diagnosed as idiopathic mpgn and administered prednisolone and cyclophosphamide (total dose of about 50,000mg). he developed end-stage renal disea ... | 1995 | 7602813 |
| transmission of hepatitis c virus from mothers to infants: its frequency and risk factors revisited. | a total of 16,714 pregnant japanese women were tested for antibodies against hepatitis c virus (hcv), and 163 (0.98%) were positive. none of these were infected with human immunodeficiency virus-1 (hiv-1). we conducted a prospective study to discover the rate of hcv infection in babies born to mothers who were hcv rna-positive but had no evidence for hepatitis (so called "asymptomatic carriers"), and only 2 (2.3%) of 87 such babies became infected during follow-up. this rate was considerably low ... | 1995 | 7605903 |
| pathology of hepatitis c virus infection. | this paper reviews our current knowledge of hepatitis c virus, its structure, epidemiology and pathological effects in man. the histopathological features of acute and chronic hepatitis due to hepatitis c virus are detailed and illustrated. the possible pathogenetic mechanisms involved in the liver injury are outlined and the significance of genotypic subtypes of the virus and of host genetic predisposition in relation to the liver injury and the response to therapy are summarized. | 1995 | 7607618 |
| post-transfusion etiology and non-cirrhotic histology improve the remission rate of chronic hepatitis c during interferon treatment. | during a 29 month period, 46 patients with chronic hepatitis c virus (hcv) received recombinant human interferon alpha-2a for 6 months and were followed for another 6 months. the dose of interferon was three million units thrice weekly and was increased to six million units if amino transferase levels failed to return to normal after 2 months of therapy. at the end of the treatment 19 patients had a complete response, 6 had a near complete response, 2 patients had breakthrough during treatment, ... | 1995 | 7607851 |
| porphyria cutanea tarda and hepatitis c viral infection. a clinical and virologic study. | the role of hepatitis c virus (hcv) infection in porphyria cutanea tarda (pct) is probable since the global hcv antibody prevalence among patients with pct is about 70%. the purpose of this study was to evaluate the virologic characteristics in 12 patients with sporadic pct and in one patient with familial pct. anti-hcv antibodies were detected by enzyme-linked immunosorbent assay and confirmed by recombinant immunoblot assay. hepatitis b virus and antihuman immunodeficiency virus markers were a ... | 1995 | 7611796 |
| variations in the core region of hepatitis c virus genomes in patients with chronic hepatitis. | in each infected patient, the population of hepatitis c virus is composed of quasispecies that differ in their nucleotide sequences. among regions in hepatitis c virus genomes, nucleotide sequences of the hypervariable region have been shown to change quickly during the course of infection. it is not known, however, whether these variations exist in the core region that has recently been suggested to contain human lymphocyte antigen class 1 restricted sites for cytotoxic t cell recognition. to c ... | 1995 | 7611880 |
| changes in lymphocyte single strand breakage and liver function of workers exposed to vinyl chloride monomer. | vinyl chloride monomer (vcm) is a suspected human carcinogen. its metabolite, chloroethylene epoxide, is able to alkylate the dna molecule and to produce single strand breakage (ssb). a total of 244 workers from 4 polyvinyl chloride (pvc) manufacturing factories were recruited to assess the ssb of their peripheral lymphocyte dna. the method of alkaline unwinding and hydroxyapatite chromatography was used to detect and calculate frequencies of ssb. in addition, hepatitis b and c markers and the l ... | 1995 | 7618165 |
| role of hepatitis c virus in chronic liver disease occurring after orthotopic liver transplantation. | paediatric orthotopic liver transplant recipients may develop chronic hepatitis after surgery. to investigate the role of hepatitis c virus in this pathology a cohort of 249 paediatric orthotopic liver transplant recipients was studied. sixteen children (6.4%) were found to have chronic hepatitis c virus hepatitis after orthotopic liver transplantation. all but one of them had serum transaminase values which were persistently raised two to eight times the upper limit of normal. thirteen were pos ... | 1995 | 7618905 |
| [anti-gor antibodies in type ii mixed cryoglobulinemia associated with hepatitis c virus infection]. | the frequent association of chronic hepatitic c virus (hcv) infection and type ii mixed cryoglobulinemia is considered to be one of the possible signs of interaction between the virus and the immune system. this could also be the case for the appearance of anti-gor antibodies in serum, as they react with both viral and host antigens. we studied a group of patients with chronic hepatitis c infection and a group with type ii mixed cryoglobulinemia associated with hcv infection to ascertain if anti ... | 1995 | 7619658 |
| [morbidity and mortality associated with chronic viral hepatopathy in patients infected with the human immunodeficiency virus]. | hepatitis b, c and d virus infection is frequent in hiv-infected individuals, particularly in drug addicts. however, chronic liver disease of viral etiology has been little studied in aids. | 1995 | 7623489 |
| correlates of hepatitis c virus infections among injection drug users. | injection drug users are at high risk for hepatitis c virus (hcv) infection. in baltimore, maryland, the prevalence of anti-hcv is greater among injection drug users who are black, human immunodeficiency virus (hiv) infected, have injected longer, have injected more frequently, and have injected cocaine than among other injection drug users. hcv infection occurs quickly after the initiation of injecting illicit drugs, with 78% of study participants anti-hcv positive after 2 years of injecting. t ... | 1995 | 7623656 |
| inhibition of hepatitis c virus replication by antisense oligonucleotide in culture cells. | oligonucleotides complementary to the sequences containing the initiator codon, aug, of the core region of positive-stranded hepatitis c virus (hcv) were tested for their effects on viral translation in a cell-free protein synthesis system and on viral replication in a human t-lymphotropic virus type i infected cell line, mt-2c, which was cloned by the limited dilution method from mt-2 cells and showed more efficient hcv replication than an uncloned population of mt-2 cells. treatment of hcv-inf ... | 1995 | 7626129 |
| suppression of hepatitis c virus (hcv) replication by hepatitis d virus (hdv) in hiv-infected hemophiliacs with chronic hepatitis b and c. | most hemophiliacs who are coinfected with human immunodeficiency virus (hiv) and hepatitis c virus (hcv) have high serum levels of hcv rna. to study the impact of multiple hepatitis virus infections, we evaluated all eight chronic carriers of hepatitis b surface antigen (hbsag) from a previously studied cohort of 99 hemophiliacs with chronic hiv and hcv infections. stored serum or plasma samples were tested for antibody to hepatitis d virus (anti-hdv) by elisa; qualitatively for hcv rna, hbv dna ... | 1995 | 7628288 |
| serologic and molecular evidence for a possible pathogenetic role of viral infection in cd3-negative natural killer-type lymphoproliferative disease of granular lymphocytes. | we studied a series of 18 patients with cd3- lymphoproliferative disease of granular lymphocytes (ldgl) for evidence of chronic viral infection, including epstein-barr (ebv), hepatitis b (hbv), hepatitis c (hcv), human t lymphotropic virus (htlv), and human immunodeficiency virus (hiv). although all patients tested had serologic evidence for past infection with ebv, polymerase chain reaction (pcr) analysis of peripheral blood mononuclear cell (pbmc) dna utilizing specific ebv primers demonstrate ... | 1995 | 7630196 |
| prognostic factors for all-cause mortality among hemophiliacs infected with human immunodeficiency virus. | to identify the prognostic significance of hemophilia- and virus-related factors, the authors undertook a survival analysis among 644 human immunodeficiency virus (hiv)-infected subjects enrolled in the multicenter hemophilia cohort study between 1985 and 1993. acquired immunodeficiency syndrome (aids) was the leading cause of death, followed by hemorrhage and hepatic disease. adverse prognostic factors included older age and cd4-positive lymphocyte values below 14 percent either at entry (age-a ... | 1995 | 7631634 |
| seroepidemiology of hepatitis b virus in a population of injecting drug users. association with drug injection patterns. | to investigate the epidemiology of hepatitis b virus (hbv) infection among injecting drug users, the authors assessed the prevalence of hbv seromarkers among 2,558 injecting drug users recruited through street outreach in baltimore, maryland, in 1988-1989. eighty percent of the drug users had at least one hbv seromarker. hbv seropositivity was associated with increasing age, duration of injecting drug use, african-american ethnicity, injecting drugs at least once daily, and sharing needles or vi ... | 1995 | 7631637 |
| occupational risk of human immunodeficiency virus, hepatitis b virus, and hepatitis c virus infections among funeral service practitioners in maryland. | to estimate the risk of exposure and infection with bloodborne pathogens, a seroepidemiologic survey was conducted among funeral service practitioners (fsps) in maryland. | 1995 | 7636165 |
| effect of hepatitis c genotype on mother-to-infant transmission of virus. | we evaluated vertical transmission of hepatitis c virus (hcv) in 37 pregnant women, 20 of whom also had human immunodeficiency virus (hiv) antibody. the hcv subtypes 1a and 3a were prevalent among pregnant women with hiv infection. infection with hcv was transmitted from 30.7% of the 13 mothers with hcv ribonucleic acid (rna) and hiv antibody and from 25% of the 8 with hcv rna alone. no mother with hcv antibody but no hcv rna transmitted hcv to her infant. subtypes 1b and 3a seemed to be the mos ... | 1995 | 7636656 |
| genomic relationship of porcine hemagglutinating encephalomyelitis virus to bovine coronavirus and human coronavirus oc43 as studied by the use of bovine coronavirus s gene-specific probes. | the genomic relationship of porcine hemagglutinating encephalomyelitis virus (hev) to bovine coronavirus (bcv) and human coronavirus (hcv) strain oc43 was examined by dot blot hybridization assays. two bcv s gene-specific probes were generated by polymerase chain reaction from the avirulent l9-strain of bcv. probes were located in the s1 and the s2 region of the peplomeric (s) glycoprotein gene. the s1 probe (726 bp) hybridized with bcv and hcv-oc43, but not with hev under moderate stringency hy ... | 1995 | 7646353 |
| [detection of hepatitis c virus rna and c33c antigen in the liver tissue from hepatitis c virus infection patients with chronic liver disease]. | to study the distribution of hepatitis c virus (hcv) in liver tissue and its pathogenesis, nonisotopic in situ hybridization with a digoxin labelled cdna probe to 5'-nc region of hcv and immunohistochemical study with monoclonal anti-body of anti hcv c33c were performed on the liver tissue from 24 hcv infection patients with chronic liver disease. the results were as follows: in the liver tissue of 17 patients with hcv infection (both elisa anti-hcv and nested pcr hcv rna positive in serum), the ... | 1995 | 7648939 |
| hepatitis c virus within a malignant lymphoma lesion in the course of type ii mixed cryoglobulinemia. | hepatitis c virus (hcv) has been implicated as the major etiologic factor sustaining b-cell clonal expansion in type ii mixed cryoglobulinemia (mc). a putative pathogenetic role of hcv in the development of mc-associated b-cell malignancies has also been speculated. we report for the first time the localization of hcv within a parotid non-hodgkin's lymphoma (nhl) lesion in the course of hcv-related type ii essential mc, an important step to implicate any infectious agent in the lymphomagenesis. ... | 1995 | 7655017 |
| interaction of polypyrimidine tract-binding protein with the 5' noncoding region of the hepatitis c virus rna genome and its functional requirement in internal initiation of translation. | initiation of translation of the human hepatitis c virus (hcv) rna genome occurs by internal ribosome entry into the 5' noncoding region (5'ncr) in a cap-independent manner. the internal ribosome entry site of the hcv 5'ncr has been previously defined to encompass almost the entire 5'ncr. here we report the interaction of polypyrimidine tract-binding protein (ptb) at three distinct regions within the 5'ncr by uv cross-linking assays. all three regions contain a consensus polypyrimidine tract mot ... | 1995 | 7666538 |
| prevalence of hepatitis b, hepatitis c, and human immunodeficiency virus markers among hospital employment applicants. | to delineate baseline seroprevalence rates before job placement, applicants for employment (n = 300) at a large urban medical center were screened for serologic markers to the hepatitis b virus (hbv), hepatitis c virus (hcv), and human immunodeficiency virus (hiv) during a 15-week period in 1992. eighteen applicants (6%) were positive for antibodies to hbv, nine (3%) for hcv, and 3 (1%) for hiv. there was no association by gender for any of these viral markers; however, both hbv and hcv were sig ... | 1995 | 7670906 |
| blood-borne virus infections among australian injecting drug users: implications for spread of hiv. | to describe the epidemiology of infection with hepatitis c virus (hcv), hepatitis b virus (hbv) and human immunodeficiency virus (hiv) among injecting drug users (idus) in australia, in relation to the potential for further spread of hiv in idus, a cross-sectional analysis was performed on data from a sample of injecting drug users, correlating markers of exposure to blood-borne viruses with sex, age, sexual orientation, primary current drug injected and duration of injecting in rural and metrop ... | 1994 | 7672048 |
| prevalence and incidence of hepatitis b virus, hepatitis c virus and human immunodeficiency virus among personnel and patients of a psychiatric hospital. | in 1989 and 1992, hiv, hbv and hcv serosurveys were carried out among personnel and patients of an italian psychiatric hospital. no hiv cases were found. mean annual hbv seroconversion rate was 0.99% in patients and 4.4% in personnel; hcv rate was 0.42% among patients. although the nosocomial risk of bloodborne infection was low, efforts should be made to minimize it. | 1995 | 7672084 |
| prevalence of hepatitis b, hepatitis c and human immune deficiency virus markers among patients with hereditary haemolytic anaemias. | to determine the prevalence of hepatitis b virus (hbv), hepatitis c virus (hcv) and human immunodeficiency virus (hiv) markers among bahraini children with hereditary haemolytic anaemias, a cross-sectional study was conducted at the paediatric outpatient clinic of sulimaniya medical center in the state of bahrain. a total of 242 patients with hereditary haemolytic anaemias were enrolled in the study: 171 (71%) with sickle cell syndromes, 59 (24%) with beta thalassaemia major and 12 (5%) with alp ... | 1995 | 7677412 |
| a multicenter study of viral hepatitis in a united states hemophilic population. | hemophilia a and b patients seen at nine us regional treatment centers were tested for serologic markers of hepatitis b virus (hbv), hepatitis c virus (hcv), and hepatitis delta virus (hdv) during 1987 and 1988. because human immunodeficiency virus (hiv) infection, a potentially confounding variable, was present in 53% of the group, the population was divided by hiv status for analysis purposes. in the hiv-positive group (n = 382), less than 1% had not been infected with hbv, hcv, or hdv, wherea ... | 1993 | 7678517 |
| expression and identification of hepatitis c virus polyprotein cleavage products. | hepatitis c virus (hcv) is the major cause of transfusion-acquired non-a, non-b hepatitis. hcv is an enveloped positive-sense rna virus which has been classified as a new genus in the flavivirus family. like the other two genera in this family, the flaviviruses and the pestiviruses, hcv polypeptides appear to be produced by translation of a long open reading frame and subsequent proteolytic processing of this polyprotein. in this study, a cdna clone encompassing the long open reading frame of th ... | 1993 | 7679746 |
| an improved method for the detection of hepatitis c virus rna in plasma utilizing heminested primers and internal control rna. | the majority of transfusion-associated, non-a, non-b hepatitis cases are caused by hepatitis c virus (hcv), a positive-stranded rna virus. although high titers of hcv in clinical specimens have been reported, in some cases extremely low titers of virus are not uncommon. therefore, an extremely sensitive and reliable assay is required to determine viremia and replication of hcv accurately. we report here the systematic investigation of factors influencing the detection of hcv rna by a reverse tra ... | 1993 | 7680265 |
| variability in the expression of a beta 2-microglobulin epitope on hepatocytes in chronic type c hepatitis on treatment with interferon. | cytotoxic cd8+ t lymphocytes recognize viral antigens in the context of human leukocyte antigen class i molecule coexpression by target cells. analysis of beta 2-microglobulin reactivity is useful in evaluating changes in human leukocyte antigen class i antigen distribution. in this study we analyzed liver biopsy specimens obtained from 15 patients with chronic active hepatitis type c who underwent a clinical trial with recombinant interferon-alpha 2b. we comparatively studied by immunohistochem ... | 1993 | 7680330 |
| significance of antibody to the host cellular gene derived epitope gor in chronic hepatitis c virus infection. | the humoral response to the host cellular gene-derived epitope gor (anti-gor) was reported to be associated with chronic hepatitis c virus (hcv) infection. to determine the prevalence and clinical significance of anti-gor, sera from 31 patients (m/f, 19/12, age 30-72) with chronic hcv infection (anti-hcv+ in 30, hcv-rna+ by pcr in 31) were tested for anti-gor by enzyme immunoassay. results were correlated with clinical, biochemical and histological features, and the subsequent response to interf ... | 1993 | 7680364 |
| hepatitis c virus infection and progression of infection due to human immunodeficiency virus. | | 1993 | 7680584 |
| lack of mother-to-infant transmission of hepatitis c virus in human immunodeficiency virus-seronegative women: a prospective study with hepatitis c virus rna testing. | the published risk of mother-to-infant transmission of hepatitis c virus varies according to the population studied and the tests used. in a prospective study we used the polymerase chain reaction to assess the risk of vertical transmission of hepatitis c virus in an unselected population of women uninfected by human immunodeficiency virus. hepatitis c virus antibodies were sought with a second-generation enzyme-linked immunosorbent assay in 2,367 consecutive pregnant women. forty-one were posit ... | 1993 | 7684017 |
| characterization of anti-liver-kidney microsome antibody (anti-lkm1) from hepatitis c virus-positive and -negative sera. | hepatitis c virus-related antibodies were found in sera positive for antibodies to liver/kidney microsome antibody, usually considered a marker of autoimmune hepatitis. the aim of this study was to analyze the specificity of this autoantibody in sera from patients with and without hepatitis c virus infection. | 1993 | 7684716 |
| improved detection of antibodies to hepatitis c virus by the second-generation assay in patients with chronic non-a, non-b liver disease. | serum samples from 337 japanese patients with chronic non-a, non-b liver disease were tested for antibodies to hepatitis c virus (hcv) by means of first-generation (c100-3; anti-c100) and second-generation (phcv-34, phcv-31, c100-3; anti-hcv ii) enzyme linked immunosorbent assays (elisa) and for antibody to the gor epitope (anti-gor) also by elisa. anti-hcv ii was detected in 314 (93.2%), anti-c100 in 247 (81.3%) and anti-gor in 211 (62.6%) samples. thus, anti-hcv ii was more sensitive in detect ... | 1993 | 7685043 |
| recombinant human interferon alfa-2b treatment for acute non-a, non-b hepatitis. | to assess the safety and possible efficacy of recombinant human interferon alfa-2b in preventing the development of chronic hepatitis, 24 adults (eight men, 16 women) with acute non-a, non-b (nanb) hepatitis were recruited to a pilot study. half of the cases were parenterally transmitted and half were community acquired. twelve patients received 3 million units (mu) interferon three times weekly subcutaneously for six weeks and the remaining 12 patients received no treatment. anti-hepatitis c vi ... | 1993 | 7686113 |
| a multivariate analysis of risk factors for hepatocellular carcinogenesis: a prospective observation of 795 patients with viral and alcoholic cirrhosis. | to elucidate the appearance rates of hepatocellular carcinoma in cirrhosis and to assess the risk factors for hepatocellular carcinogenesis, we prospectively studied 795 consecutive patients with viral or alcoholic cirrhosis for 2 to 17 yr (median of 5.8 yr). during the observation period, hepatocellular carcinoma developed in 221 patients. cumulative appearance rates of hepatocellular carcinoma were 19.4%, 44.3% and 58.2% at the end of the fifth, tenth and fifteenth years, respectively. when cl ... | 1993 | 7686879 |
| heterosexually acquired human immunodeficiency virus infection and the united states blood supply: considerations for screening of potential blood donors. hiv blood donor study group. | the impact of heterosexual transmission of the human immunodeficiency virus (hiv) on the united states blood supply was assessed, and deferral criteria that may exclude potential donors who are at high risk for heterosexually acquired hiv infection were evaluated. interviews were conducted with 508 hiv-seropositive blood donors from may 1, 1988, to august 31, 1989 (phase 1), and with 472 donors from january 1, 1990, to may 31, 1991 (phase 2), at 20 blood centers. from phase 1 to phase 2, the ove ... | 1993 | 7687391 |
| the presence of hepatitis c virus (hcv) antibody in human immunodeficiency virus-positive hemophilic men undergoing hcv "seroreversion". | hepatitis c virus (hcv) is a major cause of transfusion-induced chronic liver disease in hemophiliacs, with 70% to 90% being anti-hcv positive. seroreversion or loss of antibody response to hcv has been observed in a small proportion of human immunodeficiency virus-positive [hiv(+)] anti-hcv(+) hemophilic men. despite the seroreversion to an anti-hcv-negative state, such patients continue to show serum alanine aminotransferase (alt) elevations and biopsy evidence of cirrhosis and/or chronic acti ... | 1993 | 7687887 |
| high prevalence of thyroid autoantibodies in a prospective series of patients with chronic hepatitis c before interferon therapy. | after describing two cases of hashimoto's thyroiditis associated with chronic hepatitis c, we set up a prospective study to assess the prevalence of thyroid autoantibodies (thyroglobulin and thyroid microsomal autoantibodies) in 72 chronic hepatitis c patients (43 men and 29 women; mean age = 51 +/- 2.1 yr) before interferon therapy admitted between january and december 1991 to our liver unit. thyroid autoantibodies were systematically assayed in 60 chronic hbsag-positive patients (34 men and 26 ... | 1993 | 7687977 |
| post-transfusional anti-hcv-negative, non-a, non-b hepatitis. (i) a prospective clinical and epidemiological survey. | despite the identification of hepatitis c virus (hcv) and the detection of anti-hcv antibodies in the serum of infected individuals, a sizeable proportion of patients who develop transfusion-associated acute non-a, non-b hepatitis following surgery do not develop anti-hcv antibodies. the cause of this disease remains unknown. to assess the role of homologous blood transfusion in anti-hcv-positive and -negative, non-a, non-b hepatitis following surgery, patients receiving homologous blood, autolo ... | 1993 | 7688012 |
| post-transfusional anti-hcv-negative non-a non-b hepatitis (ii) serological and polymerase chain reaction analysis for hepatitis c and hepatitis b viruses. | hepatitis c virus (hcv) is a major etilogical agent of post-transfusional and sporadic acute and chronic hepatitis in various geographical areas. however, anti-hcv seroconversion was uncommon in a recent study of patients with post-transfusional hepatitis in paris, france (n. asar et al., companion paper). the aim of the present study was to detect viral markers, in particular hcv rna and hepatitis b virus (hbv) dna, in these patients. a combination of second-generation assays for anti-hcv antib ... | 1993 | 7688013 |
| a sensitive serodiagnosis of hepatitis c virus (hcv) infection with two non-fused peptides: comparison of antibody responses detected with a newly developed assay and a commercial second-generation test. | an enzyme-linked immunosorbent assay (elisa) was developed for the detection of anti-hcv antibody. we assayed for antibodies against either oligopeptide (s29-1) deduced from the nucleocapsid gene or the product of nonstructural region (ns3) synthesized in a recombinant escherichia coli (s4). to reduce false-positive results induced by non-specific binding of antibodies with a carrier protein and to increase the sensitivity of an immunoassay, non-fused s4 peptide was prepared by the recombinant d ... | 1993 | 7688847 |
| hepatitis c virus infection in patients infected with the human immunodeficiency virus. | the prevalence and characteristics of hepatitis c virus (hcv) infection in 226 patients who were seropositive for human immunodeficiency virus (hiv) were determined. antibody to hcv (anti-hcv) was detected by enzyme immunoassay (eia), and positive results were confirmed by a neutralization eia or recombinant immunoblot assay. the prevalence of anti-hcv was 8%. intravenous drug use was the most common risk factor for hcv infection (61.1% of patients), and 52.4% of intravenous drug users were sero ... | 1993 | 7688986 |
| low risk of sexual transmission of hepatitis c virus. | sexual transmission of hepatitis c virus (hcv) was studied between 104 anti-hcv positive index cases (99 haemophilic men, five women) who have attended the oxford haemophilia centre and 104 (98 female, 6 male) longstanding sexual partners. ninety-one percent of the index cases were hcv rna positive by the polymerase chain reaction (pcr) and 56% were anti-human immunodeficiency virus (hiv) positive. three (2.9%) sexual partners (each a female partner of a different hcv rna positive haemophilic ma ... | 1993 | 7689092 |
| b-cell epitopes on the hepatitis c virus nucleocapsid protein determined by human monospecific antibodies. | four monospecific antibodies against the hepatitis c virus nucleocapsid protein, which was expressed by recombinant baculovirus, were obtained by epstein-barr virus transformation of b cells from three patients with chronic hepatitis c virus infection. one of these antibodies was igg and the other three were igm. their specificities were characterized initially by enzyme-linked immunosorbent assay and immunoblotting against hepatitis c virus proteins expressed by six recombinant baculoviruses wi ... | 1993 | 7689529 |
| htlv-i, hiv-i, and hepatitis b and c viruses in western province, papua new guinea: a serological survey. | seven hundred and twenty-three serum samples from individuals in 13 gidra-speaking villages in western province, papua new guinea were tested for evidence of infection with human t-lymphotropic virus type i (htlv-i), human immunodeficiency virus type i (hiv-i), hepatitis b virus (hbv) and hepatitis c virus (hcv). no samples were positive for antibodies to hiv-i. antibodies to htlv-i were found in 13 samples (1.8%), hbv surface antigens (hbsag) were found in 86 samples (11.9%), and antibodies to ... | 1993 | 7690354 |
| hepatitis c virus in pregnancy: seroprevalence and risk factors for infection. | our purpose was to define the prevalence of antibodies to hepatitis c virus among inner-city prenatal patients. we also sought to examine both the reliability of traditional hepatitis risk factors to predict evidence of infection among these women and the incidence of coinfection in this population with other blood-borne and sexually transmissible agents. | 1993 | 7690523 |
| properties of a human monoclonal antibody specific for the ns4 region of hepatitis c virus. | a human monoclonal igg1(kappa) antibody (hmab) specific for a sequential epitope comprised within the 5-1-1 fragment of the ns4 region of hepatitis c virus (hcv) has been recently generated (1). in this study, b-cell clone supernatant containing the hmab was purified by passage over a protein a affinity column. preincubation with synthetic oligopeptides containing the epitope recognized by the hmab resulted in complete inhibition of binding to the whole recombinant protein, attesting to its spec ... | 1993 | 7691925 |
| hepatitis c virus-specific ctl responses in the liver of chimpanzees with acute and chronic hepatitis c. | hepatitis c virus (hcv)-specific ctl responses were evaluated in two chimpanzees (pan troglodytes) during the acute and chronic phases of hcv infection. cd8+ t lymphocytes were isolated from liver tissue homogenates using anti-cd8 antibody-coated magnetic beads and then stimulated with anti-cd3 antibodies, il-2, and irradiated human pbmc using limiting dilution culture conditions. hcv-specific cytotoxic activity of expanding cd8+ cell lines was assessed against autologous lymphoblastoid cell lin ... | 1993 | 7691940 |
| high prevalence of antibodies to hepatitis c virus in three haemodialysis centres in south-western poland. | we assessed the prevalence of anti-hepatitis c virus (anti-hcv) antibodies and markers of hepatitis b virus (hbv) infection in patients of three haemodialysis centres before initiating anti-hbv vaccinations. of the 94 patients, 39 (41.5%) were anti-hcv positive (+) and 81 (86.2%) were anti-hepatitis b core antigen (hbc) positive. there was a high rate of anti-hbc positivity among anti-hcv (+) patients (92.3%), although the presence of anti-hcv and anti-hbc antibodies were not significantly relat ... | 1993 | 7692355 |
| prevalence of anti-hepatitis c virus in the blood donor population of rio de janeiro. | the prevalence of hepatitis c virus (hcv) antibodies in 2,557 asymptomatic volunteer brazilian blood donors is reported. using the line immunoassay (inno-lia) as a confirmatory test on elisa anti-hcv-positive reacting sera, a prevalence rate of 2.7% for anti-hcv positivity was found. by comparison, prevalences of 1.6% for hepatitis b surface antigen, 0.9% for treponema pallidum, 0.4% for human immunodeficiency virus and 0.04% for trypanosoma cruzi were observed. only 57% of the hcv-positive dono ... | 1993 | 7692672 |
| low prevalence of hepatitis c virus infection in patients with auto-immune hepatitis type 1. | hepatitis c virus (hcv) antibodies were measured in 28 patients with auto-immune hepatitis type 1 using six different assay kits, three for c100-3 antibody and three for second generation hcv antibody, and two confirmatory tests to determine the prevalence of hcv infection in auto-immune hepatitis. these patients were confirmed to have human leucocyte antigen dr 4 or 2 which is susceptible to auto-immune hepatitis in japanese. of the 28 patients, four (14.3%) were positive for hcv antibody in al ... | 1993 | 7693009 |
| hepatitis c virus: guidance on the risks and current management of occupational exposure. phls hepatitis subcommittee. | hepatitis c virus (hcv) transmission after percutaneous exposure to blood at work has been documented. follow up of health care workers who report significant percutaneous or mucocutaneous exposures to sources that are known to be, or that might be, hcv-infected should include storage of serum from the source (if identifiable) and anti-hcv testing of the blood specimen obtained from the health care worker at six months post-exposure. routine testing of the health care worker's initial post-expos ... | 1993 | 7693137 |
| [recombinant antibodies in serologic diagnosis]. | in this paper we discuss the value of a new methodology for the production of monoclonal antibodies by recombinant techniques. this approach is especially useful for human monoclonal antibodies due to instability of human antibody-producing cell lines. as an example, we present a recombinant human antibody to the hepatitis c virus (hcv) core protein. | 1993 | 7693244 |
| hla b44-restricted cytotoxic t lymphocytes recognizing an epitope on hepatitis c virus nucleocapsid protein. | cytotoxic t lymphocytes have been reported to be involved in the immune clearance of virus-infected cells and in the pathogenesis of viral infection. we studied the cytotoxic t lymphocyte response to the putative nucleocapsid protein of hepatitis c virus in patients with chronic hepatitis c. cytotoxic t lymphocytes specific for hepatitis c virus nucleocapsid protein were generated from peripheral blood lymphocytes by means of repeated stimulation with a synthetic hepatitis c virus nucleocapsid p ... | 1993 | 7693568 |
| long-term serologic follow-up of hepatitis c virus-seropositive homosexual men. | hepatitis c virus (hcv) infection may go undiagnosed and continue to present a source of community-acquired or transfusion-associated infection because of shortcomings in sensitivity, specificity, and reproducibility of serologic tests. this project was designed to longitudinally study persons who were hcv seropositive or were at risk for seroconversion to characterize the course of infection. sequential serum samples obtained semiannually from 617 homosexual male volunteers were available for s ... | 1995 | 7697532 |
| effect of interferon therapy in a patient with chronic active hepatitis type c associated with interstitial pneumonia and rheumatoid arthritis: a case report. | interferon (ifn) is widely used to treat patients with chronic hepatitis types b and c but has been found to occasionally aggravate rheumatoid arthritis (ra) or cause interstitial pneumonia. we administered 6 miu/d ifn-beta by intravenous injection for 6 weeks to a 55-year-old man with chronic active hepatitis type c associated with ra and interstitial pneumonia. transaminase levels rapidly returned to normal after treatment and hepatitis c virus-rna (nested rt-pcr method) was negative on comple ... | 1994 | 7697682 |
| non-muscle myosin as target antigen for human autoantibodies in patients with hepatitis c virus-associated chronic liver diseases. | three patients with hepatitis c virus (hcv)-related chronic liver disease were shown to have autoantibodies strongly reacting with cytoskeletal fibres of non-muscle cells. the heavy chain of non-muscle myosin microfilament was the main target for those autoantibodies, as determined by (i) cell and tissue immunofluorescence studies showing colocalization with an anti-myosin antibody prototype; (ii) primary reactivity in immunoblotting with a 200-kd protein, using either molt-4 cells, human platel ... | 1995 | 7697925 |
| failure to incriminate hepatitis b, hepatitis c, and hepatitis e viruses in the aetiology of fulminant non-a non-b hepatitis. | sporadic non-a, non-b hepatitis is the most common indication for liver transplantation in patients presenting with fulminant and subacute liver failure. this study used serological, histological, and molecular biological techniques to examine specimens from 23 consecutive patients transplanted for sporadic non-a, non-b hepatitis. no evidence was found of hepatitis c virus, hepatitis e virus, or 'cryptic' hepatitis b virus infection. | 1995 | 7698704 |
| should patients with human immunodeficiency virus infection or chronic hepatitis donate blood for autologous use? | the purpose of this project is to formally evaluate the benefits and the risks of allowing patients with human immunodeficiency virus (hiv) infection or hepatitis to donate blood for autologous use. | 1995 | 7701551 |
| patients, needles, and health care workers. | the risk of transmission of blood-borne pathogens in the health care environment is determined by three main factors: the nature and frequency of exposure to blood or body fluids, the risk of transmission of infection after a single exposure to the pathogen, and the prevalence of infected and susceptible patients and health care workers. in this article, all three parts of the risk equation are examined and brought into focus by addressing the risks and pathologic consequences of infection with ... | 1995 | 7707172 |
| immunological abnormalities in hiv-free haemophiliacs. | since some haemophiliacs manifest profound immunodeficiency with no evidence of human immunodeficiency virus type 1 (hiv) infection, we measured the circulating immune complex (cic) level in sera obtained from haemophiliacs and addressed the question of whether viral infection is associated directly or indirectly with enhanced cic production. while more than 90% of hiv-positive individuals had a high level of cic, around 60% of seronegative ones also showed cic levels comparable to those of sero ... | 1993 | 7707343 |
| hepatitis c virus in breast milk. | | 1995 | 7707835 |
| [methods of study of the hepatitis c virus genome. diagnostic tools in human pathology]. | the study of the molecular biology of infectious agents involves the examination of their genomes and the products of those genomes. molecular biology methods may therefore allow us to study either dnas or rnas. the study of genomic rnas (viruses) or messenger rnas (all infectious agents) is used increasingly in infectious disease pathology. the hepatitis c virus was identified in 1989 and was shown to be responsible for a large number of chronic hepatitis cases in france and worldwide. this vir ... | 1995 | 7711774 |
| unbiased usage of t-cell receptor beta variable region genes in peripheral blood cells of hepatitis c patients: no correlation with superantigen effect. | hepatitis c virus (hcv) infection frequently causes chronic hepatitis and lack of virus clearance in these patients. in addition, many patients infected by hcv also present with hypergammaglobulinemia in the early stage of chronic infection. these observations raise a possible viral superantigen effect induced by hcv, because viral superantigen found in human immunodeficiency virus (hiv) or in replication of defective murine leukemia virus (mulv) is associated with t-cell dysfunction and polyclo ... | 1995 | 7714489 |
| clinical recurrence of hepatitis a following liver transplantation for acute liver failure. | this paper documents clinically significant recurrence of hepatitis a virus (hav) infection in a 63-year-old man transplanted for hav-related acute liver failure. hav rna was documented in the explant and, following early clearance from the blood and graft, was again detected in post-operative biopsies at the time of an acute hepatic illness. although the clinical and biochemical abnormalities resolved completely, the patient had a second episode of graft dysfunction 6 months later and investiga ... | 1995 | 7714491 |
| trans-suppression of gene expression by hepatitis c viral core protein. | we have demonstrated that the truncated hepatitis c (hcv) core protein with its c-terminal hydrophobic domains deleted is translocated to the nucleus of transfected cells (22). in this study, intact and truncated core proteins of hcv were transiently expressed in a human hepatoblastoma cell line, hepg2, and their effects on the expression of the chloramphenycol acethyl transferase (cat) gene driven by viral and cellular promoters were examined. the intact core protein of 22 kda which is localize ... | 1994 | 7715094 |
| treatment and prevention of chronic viral hepatitis. | chronic viral hepatitis caused by hepatitis b, c or d may lead to cirrhosis, hepatocellular failure and hepatocellular carcinoma. the morbidity of these diseases has necessitated a prolonged search for effective therapy. interferon-alpha has been studied widely, and remains the mainstay of treatment. therapy for hepatitis b has now become possible with the demonstration that alpha-interferons inhibit hepatitis b virus (hbv) replication and that prolonged therapy can lead to a remission in diseas ... | 1995 | 7716182 |
| [the behavior and perinatal impact of viral hepatitis in pregnancy]. | the association between viral hepatitis and pregnancy is not common, nevertheless it has been described that hepatitis is the most frequent cause of jaundice in pregnant women. in this article the current knowledge on the perinatal repercussions of the different types of viral hepatitis are reviewed. hepatitis a is rare during pregnancy and is not associated with perinatal risk. hepatitis b virus (hbv) can be transmitted transplacentally, 20 per cent of the children infected by this route will d ... | 1994 | 7716369 |
| antibodies anti-parvovirus b19 in chronic hepatitis c virus infection. | | 1995 | 7717346 |
| posttransfusional, lkm-1-autoantibody-positive hepatitis c virus infection, cryoglobulinemia, and aplastic anemia. | aplastic anemia is occasionally caused by viral hepatitis, hepatitis c virus being the most important factor. pathogenetically, decreased bone marrow function, abnormalities of the bone marrow microenvironment, and immune-mediated suppression of hematopoiesis are important. hepatitis c virus infection is associated with a variety of extrahepatic manifestations including autoimmune features like cryoglobulinemia, sjögren's syndrome, and autoimmune hepatitis. here we report the case of a 42-year-o ... | 1995 | 7720468 |
| risk for hepatitis c virus (hcv) and human immunodeficiency virus (hiv) infections among prostitutes. | | 1993 | 7721298 |
| identification of two flavivirus-like genomes in the gb hepatitis agent. | a subtractive pcr methodology known as representational difference analysis was used to clone specific nucleotide sequences present in the infectious plasma from a tamarin infected with the gb hepatitis agent. eleven unique clones were identified, seven of which were examined extensively. all seven clones appeared to be derived from sequences exogenous to the genomes of humans, tamarins, saccharomyces cerevisiae, and escherichia coli. in addition, sequences from these clones were not detected in ... | 1995 | 7724574 |
| [hepatitis viruses]. | five different hepatitis viruses that cause acute and chronic hepatitis in human beings have been identified. hepatitis viruses are designated by the letters a, b, c, d and e and abbreviated as hav, hbv, hcv, hdv, and hev, respectively. although each belongs to a distinctly different virologic group, they share the feature of hepatotropism, which remains poorly understood. hav and hev are transmitted through a fecal-oral route. hdv, also referred to as the delta agent, is a defective, parenteral ... | 1995 | 7725016 |
| [serum biological markers and screening of viral hepatitis]. | the diagnosis of hepatitis a is based on igm anti-hav positivity. igg anti-hav indicates immunity from further infections of hepatitis a. in acute hepatitis b, hbs ag is the first marker to appear in the serum, followed by hbe ag and anti-hbc. after recovery, hbs ag disappears, anti-hbs appears with anti-hbe and anti-hbc and persists for many years. anti-hbs is indicative of recovery and immunity. chronic hepatitis b infection is defined as the persistence of hbs ag for more than 6 months. the p ... | 1995 | 7725017 |
| [extra-hepatic manifestations of viral hepatitis]. | a variety of prodromal symptoms of viral hepatitis (urticaria, fever, arthralgias, headache, polyradiculonevritis) are attributed to a, b, c, d or e hepatitis only when jaundice appears, and because they disappear with it. spectacular extrahepatic symptoms (polyarteritis nodosa, cryoglobulinemia, glomerulonephritis, marrow aplasia...) may be associated with b or c hepatitis without any liver symptom. some of the extrahepatic symptoms observed during chronic hepatitis c therapy with interferon (t ... | 1995 | 7725020 |
| characterization of an established human hepatoma cell line constitutively expressing non-structural proteins of hepatitis c virus by transfection of viral cdna. | a human hepatoma cell line constitutively expressing proteins of hepatitis c virus (hcv) was established by transfection with cdna encoding part of the virus nonstructural (ns) genome region. proteins consistent with authentic processing at ns3/ns4a, ns4a/ns4b and ns4b/ns5a were identified. pulse-chase experiments indicated that the cleavage between ns3 and ns4a occurred first and cleavage at other sites followed. expression of specific surface antigens in response to the presence of hcv protein ... | 1995 | 7730805 |
| [treatment of chronic hepatitis c virus infection with interferon in patients infected with the human immunodeficiency virus]. | we assessed the effectivity of the treatment with interferon (ifn) in patients infected by the human immunodeficiency virus (hiv) with chronic hepatitis (ch) by the hepatitis c virus (hcv). | 1994 | 7734662 |
| increased prevalence of htlv-i infection in patients with hepatocellular carcinoma associated with hepatitis c virus. | the progression from chronic hepatitis c virus (hcv) infection to hepatocellular carcinoma (hcc) has been reported. we evaluated whether co-infection with the human t-lymphotropic virus type i (htlv-i) might be associated with this transition in a cross-sectional analysis of 127 patients with hcv-chronic hepatitis (mean age = 51.7) and 43 patients with hcv-associated hcc (mean age = 62.4); the seroprevalence of anti-htlv-i was 9.5% and 30.2%, respectively. for subjects 50 years or older, the ser ... | 1995 | 7737899 |
| clinical outcomes after transfusion-associated hepatitis c. | the extent of serious complications in people who have acquired chronic hepatitis c infection after a blood transfusion is unclear. | 1995 | 7739682 |
| [treatment of chronic virus hepatitis with acetylsalicylic acid]. | the treatment of chronic hepatitis b and c with recombinant interferon (ifn) has only poor durable response rates. in the past only the lack of any prior effective therapy regimen could justify the use of this expensive agent. dose escalating or prolonged treatment courses did not enhance the rate of sustained remissions. pre- or cotreatment with antiviral (e.g. acyclovir, ribavirin, isoprenosin) or immunomodulating (e.g. prednisone, gamma ifn) drugs have not influenced the resistance to exogeno ... | 1995 | 7740291 |
| human immunodeficiency virus infection and porphyria cutanea tarda: coexistence of risk factors or causative association? | several recent reports have described an association between human immunodeficiency virus (hiv) infection and porphyria cutanea tarda (pct). we describe two hiv-infected patients who developed pct and review 29 other reported cases of coexistent pct and infection due to hiv. recognized porphyrinogenic factors were identified in our patients and in 27 of the 29 cases described in the literature. even in the two cases that lacked obvious precipitant factors for pct, the possibility of hepatitis c ... | 1995 | 7742441 |
| closed video transurethral resection of the prostate for the prevention of infection. | an instrument with which safe and clean video transurethral resection of the prostate (video turp) can be performed has been developed by the author; its use could minimize the risk to the operating staff of being infected by such dangerous viruses as human immunodeficiency virus (hiv), hepatitis b virus (hbv), and hepatitis c virus (hcv). the instrument consists of a bag made of transparent synthetic resin (polyvinyl chloride), used to cover the patient's penis and a resectoscope with a super m ... | 1995 | 7744138 |
| arsphenamine jaundice and the recognition of instrument-borne virus infection. | soon after its introduction in 1910, intravenous arsphenamine treatment for syphilis was found to be complicated by jaundice. the underlying cause, unsterile syringes and needles, was eventually recognised in the early 1940s, mainly through the efforts of british army investigators. the infection most often transmitted was probably hepatitis b virus (hbv), but the high mortality in a few of the outbreaks of arsphenamine jaundice suggests that variants of hbv, or other hepatitis viruses, were som ... | 1995 | 7744400 |
| successful cyclophosphamide treatment of cryoglobulinemic membranoproliferative glomerulonephritis associated with hepatitis c virus infection. | a 54-year-old man with cryoglobulinemia and chronic hepatitis c infection presented with progressive renal insufficiency caused by membranoproliferative glomerulonephritis. because of a steady decline in renal function, cyclophosphamide therapy was instituted. within 1 month of starting therapy, his cryoglobulins disappeared, and in 3 months, his creatinine clearance had improved from 56 ml/min to 89 ml/min. at no point in his course was there clinical evidence of liver disease. after 1 year, cy ... | 1995 | 7747735 |
| epidemiology of viral infections in the swedish blood-donor population. | the epidemiological situation regarding blood-borne infections in sweden is favourable and under very good control. the prevalence of infectious markers in the blood-donor population is low. in 1993 the frequencies of confirmed positive tests were three in 1,000,000 for human immunodeficiency virus type-1 (hiv-1), one in 100,000 for hepatitis b virus (hbv) and three in 100,000 for hepatitis c virus (hcv). the safety of the blood supply is high and relies on strict donor selection, information on ... | 1994 | 7749044 |
| viral safety of solvent/detergent-treated blood products. | laboratory research that began in 1982 led to the licensing in the usa of a solvent/detergent (sd)-treated factor viii concentrate in 1985. the licence was granted on the basis of several factors. first, studies had demonstrated the inactivation of several marker viruses (vesicular stomatitis virus, sindbis virus, sendai virus) and other viruses such as human immunodeficiency virus (hiv), hepatitis b virus (hbv), and non-a, non-b hepatitis virus (nanbhv; now known principally to be hepatitis c v ... | 1994 | 7749045 |
| blood-borne viral infections. | the selection of blood donors and the introduction of tests identifying virus-infected donors has led to a permanent increase in the safety of blood transfusion. in most european countries, there is a low risk of infection from viruses such as hepatitis b virus, hepatitis c virus and human immunodeficiency virus. examples of viruses that pose a risk to children but not adults following transfusion-transmitted infection are parvovirus b19 and cytomegalovirus. other viruses may be transmitted in t ... | 1994 | 7749048 |
| variants of hepatitis b, c and d viruses: molecular biology and clinical significance. | variants of hepatitis b virus (hbv), hepatitis c virus (hcv) and of the hepatitis delta virus (hdv) have been identified in patients both with acute and chronic infections. in the hbv dna genome, naturally occurring mutations have been found in all viral genes, most notably in the genes coding for the structural envelope and nucleocapsid proteins. in the hcv rna genome, the regions coding for the structural envelope proteins 1 and 2 as well as the 3'-contiguous nonstructural region 1 were found ... | 1995 | 7750674 |
| [viral markers of acute hepatitis: a, b, c, d, and e in dakar. october 92 - october 93]. | inside of 95 patients presented in hospital with presumed hepatitis: 77 were recruted with liver cytolysis (amino-transferases at > 80 ui/ml) and included in this study. study of serologic viral markers (a, b, c, d and e type) permited to prove viral acute hepatitis infection and 49 patients were recruted inside the 77 cytolytic cases. inside these 49 cases: 44% presented enteritic contamination with hav/hev markers, 36% with hbv markers: hbs/hbc, 6% with hbs/hbe markers, 10% with hdv marker, 4% ... | 1993 | 7758379 |
| perinatal transmission and manifestation of hepatitis c virus infection in a high risk population. | we studied the perinatal transmission of hepatitis c virus (hcv) in 70 high risk mother/infant pairs. seventy-six percent of the mothers (53 of 70) were coinfected with human immunodeficiency virus (hiv) and 79% (55 of 70) had a history of drug addiction. during the follow-up hcv rna was detected in 14 of 70 (20%) infants: 12% (2 of 17) in infants born to hiv-negative mothers; and 23% (12 of 53) in infants to hiv-positive mothers. the rate of vertical transmission was significantly higher in vag ... | 1995 | 7761184 |
| molecular mimicry between fc receptor and s peplomer protein of mouse hepatitis virus, bovine corona virus, and transmissible gastroenteritis virus. | we have previously demonstrated molecular mimicry between the s peplomer protein of mouse hepatitis virus (mhv) and fc gamma r (fc gamma r). a monoclonal antibody (mab) to mouse fc gamma r (2.4g2 anti-fc gamma r mab), purified rabbit immunoglobulin, but not their f(ab')2 fragments, as well as mouse and rat igg, immunoprecipitated (1) recombinant s peplomer protein expressed by a vaccinia virus recombinant in human, rabbit, and mouse cells, and (2) natural s peplomer protein from cells infected w ... | 1995 | 7768529 |
| hypocomplementaemic urticarial vasculitis, interstitial lung disease and hepatitis c. | a 42-year-old man developed persistent urticaria and angio-oedema responsive to systemic steroids. a skin biopsy revealed leucocytoclastic vasculitis. c4 levels were consistently decreased in the setting of a mildly elevated erythrocyte sedimentation rate. pulmonary function studies revealed a restrictive pattern, and there was eosinophilia in bronchial lavage fluid. antibody to hepatitis c virus was positive, and there was mild elevation of serum aminotransferase. we believe that this case repr ... | 1995 | 7772493 |
| [a prevalence study of serum markers in hepatitis virus infection in the epidemiological anamnesis of the population]. | pandemic of the infections with hepatitis viruses is a priority in public health. in romania, the very high acute and chronic morbidity by viral hepatitis demands the rapid implementation of a feasible preventive program. in the population of 5 districts from transylvania we conducted a sero-epidemiological survey in order to find the real and specific characteristics of the prevalence of the infections with hepatitis viruses. the study was a cross-sectional study on the anamnestic presence of t ... | 1994 | 7772886 |