| rabies acquired through kidney transplantation in a child: a case report. | rabies is usually transmitted to humans through bites of infected animals; however, it can rarely be transmitted through deceased donor organs or tissues when not suspected. here, we report a case of rabies transmission in a child. the child was a 5-year-old girl who was admitted to the pediatric intensive care unit with encephalitis of unexplained cause 3.5 months after she received a kidney transplant from a deceased donor. the laboratory and imaging studies did not reveal any explanation for ... | 2017 | 28411355 |
| comparison of the immunogenicity and safety of the purified chick embryo cell rabies vaccine manufactured in india and germany: a randomized, single blind, multicentre, phase iv clinical study. | this phase iv, single blind study assessed the immunogenicity and safety of india-manufactured purified chick embryo cell rabies vaccine (pcecv), compared with a german-manufactured batch obtained by the same production process. a total of 340 participants enrolled at 2 study sites in india were randomized (1:1:1:1) in 4 groups to receive a 5-dose essen regimen with either 1 of the 3 indian batches (pcecv-i) or the german batch (pcecv-g), administered on days (d) 0, 3, 7, 14 and 30. the lot-to-l ... | 2017 | 28406752 |
| pathobiological investigation of naturally infected canine rabies cases from sri lanka. | the recommended screening of rabies in 'suspect' animal cases involves testing fresh brain tissue. the preservation of fresh tissue however can be difficult under field conditions and formalin fixation provides a simple alternative that may allow a confirmatory diagnosis. the occurrence and location of histopathological changes and immunohistochemical (ihc) labelling for rabies in formalin fixed paraffin embedded (ffpe) canine brain is described in samples from 57 rabies suspect cases from sri-l ... | 2017 | 28403882 |
| development and evaluation of the rt-pcr kit for the rabies virus diagnosis. | to improve the diagnosis, surveillance, and control for the rabies virus, a kit for hybridization-triggered fluorescence detection of rabies virus dna by the rt-pcr technique was developed and evaluated. the analytical sensitivity of the kit was 4*10 ge per ml. high specificity of the kit was shown using representative sampling of viral, bacterial, and human nucleic acids. | 2018 | 29323857 |
| study of rabies virus by differential scanning calorimetry. | differential scanning calorimetry (dsc) has been used in the past to study the thermal unfolding of many different viruses. here we present the first dsc analysis of rabies virus. we show that non-inactivated, purified rabies virus unfolds cooperatively in two events centered at approximately 62 and 73 °c. beta-propiolactone (bpl) treatment does not alter significantly viral unfolding behavior, indicating that viral inactivation does not alter protein structure significantly. the first unfolding ... | 2015 | 29124221 |
| prokaryotic expression, purification, and polyclonal antibody production of a truncated recombinant rabies virus l protein. | rabies virus (rabv) is a deadly neurotropic virus that causes the disease of rabies in humans and animals. l protein is one of the large structural protein of rabies virus, which displays multiple enzymatic activities, and is required for viral transcription and replication. | 2015 | 28959286 |
| very-long-range disynaptic v1 connections through layer 6 pyramidal neurons revealed by transneuronal tracing with rabies virus. | neurons in primary visual cortex (v1) integrate across the representation of the visual field through networks of long-range projecting pyramidal neurons. these projections, which originate from within v1 and through feedback from higher visual areas, are likely to play a key role in such visual processes as low contrast facilitation and extraclassical surround suppression. the extent of the visual field representation covered by feedback is generally much larger than that covered through monosy ... | 2014 | 28539788 |
| predicting the presence and titre of rabies virus-neutralizing antibodies from low-volume serum samples in low-containment facilities. | serology is a core component of the surveillance and management of viral zoonoses. virus neutralization tests are a gold standard serological diagnostic, but requirements for large volumes of serum and high biosafety containment can limit widespread use. here, focusing on rabies lyssavirus, a globally important zoonosis, we developed a pseudotype micro-neutralization rapid fluorescent focus inhibition test (pmrffit) that overcomes these limitations. specifically, we adapted an existing micro-neu ... | 2020 | 32931658 |
| defining new pathways to manage the ongoing emergence of bat rabies in latin america. | rabies transmitted by common vampire bats (desmodus rotundus) has been known since the early 1900s but continues to expand geographically and in the range of species and environments affected. in this review, we present current knowledge of the epidemiology and management of rabies in d. rotundus and argue that it can be reasonably considered an emerging public health threat. we identify knowledge gaps related to the landscape determinants of the bat reservoir, reduction in bites on humans and l ... | 2020 | 32911766 |
| efficacy of ontario rabies vaccine baits (onrab) against rabies infection in raccoons. | in the us, rabies lyssavirus (rabv) only circulates in wildlife species and the most significant reservoir from a public and animal health perspective is the raccoon (procyon lotor). management of wildlife rabies relies principally on oral rabies vaccination (orv) strategies using vaccine-laden bait delivery to free-ranging target hosts, in order to reduce the susceptible population to prevent the spread of and eliminate rabv circulation. our objective was to evaluate efficacy of the ontario rab ... | 2018 | 30037482 |
| human rabies associated with domestic cat exposures in south africa, 1983-2018. | no abstract available. | 2020 | 32633988 |
| updates on rabies virus disease: is evolution toward zombie virus a tangible threat? | human rabies disease is caused by rabies lyssavirus, a virus belonging to rhabdoviridae family. the more frequent means of contagion is through bites of infected mammals (especially dogs, but also bats, skunks, foxes, raccoons and wolves) which, lacerating the skin, directly inoculate virus-laden saliva into the underlying tissues. immediately after inoculation, the rabies virus enters neural axons and migrates along peripheral nerves towards the central nervous system, where it preferentially l ... | 2021 | 33682816 |