| severe asymptomatic rhabdomyolysis complicating a mycoplasma pneumonia. | rhabdomyolysis is a very rare and serious extrapulmonary manifestation of a mycoplasma pneumoniae infection. we describe a case of a 47-year-old male patient who presented with progressive dyspnoea, hypoxaemia and cough during the last 3 days. he had no relevant muscular complaints but was diagnosed with severe rhabdomyolysis for which he was treated with hyperhydration. molecular diagnostics confirmed m. pneumoniae as the causative agent and our patient was successfully treated with doxycycline ... | 2017 | 28747412 |
| a rapid, low-cost, and microfluidic chip-based system for parallel identification of multiple pathogens related to clinical pneumonia. | an air-insulated microfluidic chip was designed for the automatic centrifugal distribution of samples to 24-test cells, enabling the parallel identification of multiple clinical pneumonia-related pathogens in 1.45-μl reactions without cross-contamination in 45 min. a portable nucleic acid analyzer that integrates mechanical, confocal optical, electronic, and software functions was also developed to collect fluorescence data in a ø3 mm imaging field near the optical diffraction limit for highly s ... | 2017 | 28743917 |
| a comparison study between gexp-based multiplex-pcr and serology assay for mycoplasma pneumoniae detection in children with community acquired pneumonia. | diagnosis of community-acquired pneumonia (cap) caused by mycoplasma pneumoniae (mp) in children has been hampered by difficulty in obtaining convalescent serum and time constraints. in this study, the two diagnostic assays that targeted respectively on mp-antibody and mp-dna were retrospectively investigated. | 2017 | 28743259 |
| pediatric mycoplasma pneumoniae infection presenting with acute cholestatic hepatitis and other extrapulmonary manifestations in the absence of pneumonia. | mycoplasma pneumoniae infections mainly involve respiratory tract; however, also can manifestate other symptoms by site involved. extrapulmonary manifestations of m. pneumoniae infection are rarely known to occur without pneumonia. herein we report a case of a 9-year-old boy who presented with acute cholestatic hepatitis in the absence of pneumonia. rhabdomyolysis, skin rash, and initial laboratory results suspicious of disseminated intravascular coagulopathy were also observed in this patient. ... | 2017 | 28730137 |
| mycoplasma pneumoniae-associated hepatitis without lung involvement. | mycoplasma pneumoniae (m. pneumoniae) is a major cause of community acquired respiratory infections. and it also causes a number of extrapulmonary manifestations including cardiovascular, dermatological, musculoskeletal, and hematological systems. but, acute hepatitis without lung involvement is rare in adults. here, we report a case of 32-year-old man who presented with fever, chilling, myalgia, and headache. biochemical analysis showed severely impaired liver function and leukopenia. laborator ... | 2017 | 28728317 |
| [exploratory research on diagnostic essentials of pediatric tuberculous pleurisy]. | objective: to summarize the clinical diagnostic essentials of pediatric tuberculous pleurisy so as to reduce the misdiagnosis rate. method: a retrospective study was conducted on 113 cases of tuberculous pleurisy who were seen from august 2006 to september 2014 in the second department of respiratory medicine, beijing children's hospital affiliated to capital medical university. meanwhile, another 113 cases of children over 5 years of age with mycoplasma pneumoniae pneumonia complicated with ple ... | 2017 | 28728264 |
| cytokines as the predictors of severe mycoplasma pneumoniae pneumonia in children (review). | in spite of many attempts to differentiate bacterial from viral disease and predict severity and outcome, the etiologic diagnosis of paediatric community acquired pneumonia and the estimation of potential outcomes remain unsolved problems in most cases. mycoplasma pneumoniae is one of the major pathogens causing cap in children. although mp infection was traditionally thought to be a self-limited process, more and more severe cases even fatal cases of mp infections were reported in recent years. ... | 2017 | 28726662 |
| comparison of oropharyngeal and nasopharyngeal swab specimens for the detection of mycoplasma pneumoniae in children with lower respiratory tract infection. | the oropharyngeal swab specimen was superior to the nasopharyngeal swab specimen for the detection of mycoplasma pneumoniae in children with lower respiratory tract infection. the oropharyngeal loop-mediated isothermal amplification had 100% sensitivity and specificity compared with polymerase chain reaction testing, whereas the oropharyngeal rapid antigen detection test using immunochromatographic assay had relatively low sensitivity (66%) and reasonable specificity (90.7%). | 2017 | 28712517 |
| severe sequelae of erythema multiforme: three cases. | erythema multiforme (em) is a skin condition for which main causes are infectious factors (herpes simplex virus, mycoplasma pneumoniae). anti-plakin auto-antibodies are found in some patients (1) . em must be distinguished from stevens-johnson syndrome (sjs) and toxic epidermal necrolysis (ten), which are drug-induced in most cases (2-5) . this article is protected by copyright. all rights reserved. | 2017 | 28710842 |
| [effect of annexin a2 on egfr/nf-κb signal transduction and mucin expression in human airway epithelial cells treated with mycoplasma pneumoniae]. | to investigate the effect of annexin a2 (anxa2) on epithelial growth factor receptor (egfr)/nuclear factor-κb (nf-κb) signal transduction and mucin expression in human airway epithelial h292 cells treated with mycoplasma pneumoniae (mp). | 2017 | 28697839 |
| [effects of huaiqihuang granules on immune function in children with severe mycoplasma pneumoniae pneumonia]. | to observe the effects of huaiqihuang granules on the immune function in children with severe mycoplasma pneumoniae pneumonia. | 2017 | 28697827 |
| mechanism of resistance acquisition and treatment of macrolide-resistant mycoplasma pneumoniae pneumonia in children. | mycoplasma pneumoniae pneumonia (mpp) is one of the most common forms of community-acquired pneumonia in children and adolescents. outbreaks of mpp occur in 3- to 7-year cycles worldwide; recent epidemics in korea occurred in 2006-2007, 2011, and 2015-2016. although mpp is known to be a mild, self-limiting disease with a good response to macrolides, it can also progress into a severe and fulminant disease. notably, since 2000, the prevalence of macrolide-resistant mpp has rapidly increased, espe ... | 2017 | 28690643 |
| [mycoplasma pneumoniae: update and new challenges]. | mycoplasma pneumoniae is a frequent cause of community acquired pneumonia, especially in children. discovered by eaton in the 1940s, it has long been considered as a virus, in part because of its difficult growth in cultures. m. pneumoniae can cause many complications, some of which are severe such as dermatological lesions or affections of the central nervous system. the laboratory diagnosis of m. pneumoniae is difficult, notably because of the fastidious growth conditions, the persistence of i ... | 2016 | 28686393 |
| acute kidney injury and hemolytic anemia secondary to mycoplasma pneumoniae infection. | glomerulonephritis as well as kidney injury secondary to fulminant intravascular hemolysis are rare extrapulmonary manifestations of mycoplasma pneumoniae infection. we describe a 50-year-old female diagnosed with m. pneumoniae infection-associated hemolytic anemia, characterized by negative cold agglutinin tests but with laboratory evidence of complement alternative pathway activation. the patient presented both with anemia and severe kidney failure and she was treated with steroids and red blo ... | 2017 | 28683450 |
| the association between mycoplasma pneumoniae infection and speech and language impairment: a nationwide population-based study in taiwan. | manifestations of mycoplasma pneumoniae infection can range from self-limiting upper respiratory symptoms to various neurological complications, including speech and language impairment. but an association between mycoplasma pneumoniae infection and speech and language impairment has not been sufficiently explored. in this study, we aim to investigate the association between mycoplasma pneumoniae infection and subsequent speech and language impairment in a nationwide population-based sample usin ... | 2017 | 28672017 |
| correlation study of cough variant asthma and mycoplasma pneumonia infection in children. | cough variant asthma (cva), as one of bronchitis diseases, features with repeated cough. in clinics, cav does not show significant abnormal signs, therefore antibiotic therapy can hardly achieve satisfactory treatment effect. with the development of scientific technologies, the correlation between mycoplasma pneumoniae infection and cva has become a hot research topic in clinics. in clinics, mycoplasma pneumoniae is extensively regarded as major cause for cva, with complex pathogenic mechanism. ... | 2017 | 28671088 |
| changes in pathogens and pneumococcal serotypes causing community-acquired pneumonia in the netherlands. | in 2006 a 7-valent pneumococcal conjugate vaccine (pcv7) was introduced in the immunisation programme for infants in the netherlands and replaced by pcv10 in 2011. limited data exist about the impact of pcv on the aetiology of cap as a whole. the aim of the present study is to describe the overall changes in microbial aetiology, pneumococcal burden (including non-bacteraemic pneumococcal pneumonia) and its serotypes in adult community-acquired pneumonia (cap) after the introduction of these pcvs ... | 2017 | 28668570 |
| comparison of the ameliorative effects of qingfei tongluo formula and azithromycin on mycoplasma pneumoniae pneumonia. | mycoplasma pneumoniae pneumonia (mpp) is a common disease in children. qingfei tongluo formula (qtf) has been used for the treatment of mpp clinically, but the therapeutic effect remains unclear compared to conventional treatments with western medicines. therefore, the aim of this study was to assess changes in the expression levels of relevant factors associated with microcirculation after mpp and to compare the therapeutic effect of qtf with that of azithromycin (azm) on experimental mice with ... | 2017 | 28664473 |
| 50 years ago in the journal of pediatrics: primary atypical pneumonia: an epidemic caused by mycoplasma pneumoniae. | | 2017 | 28648271 |
| things that could be mycoplasma pneumoniae. | m. pneumoniae infection gives rise to a wide variety of manifestations. the pathogenesis of secondary manifestations is not always known. some depend on the direct invasion of m. pneumoniae and others on the indirect effect of m. pneumoniae through pathological immune responses, for instance autoreactive antibodies in guillain-barré syndrome. diagnosis remains challenging with currently available diagnostic tests, because they do not demonstrate a causal relation due to m. pneumoniae asymptomati ... | 2017 | 28646969 |
| evaluation of variation in coagulation among children with mycoplasma pneumoniae pneumonia: a case-control study. | objective acute organ embolism in children with mycoplasma pneumoniae pneumonia (mpp) has been reported, but changes in coagulation are unclear. this study aimed to investigate changes in coagulation in children with mpp. methods a total of 185 children with mmp (cases) and 117 healthy children (controls) were recruited. we measured prothrombin time (pt), activated partial thromboplastin time (aptt), thrombin time (tt), and plasma fibrinogen (fib) and d-dimer levels. results plasma fib (3.39 ± 0 ... | 2017 | 28643533 |
| mycoplasma pneumoniae and health outcomes in children with asthma. | acute infections with mycoplasma pneumoniae (mp) have been associated with worsening asthma in children. mp can be present in the respiratory tract for extended periods; it is unknown whether the long-term persistence of mp in the respiratory tract affects long-term asthma control. | 2017 | 28634021 |
| complete genome sequences of the p1 gene type 2b and 2c strains mycoplasma pneumoniae kch-402 and kch-405. | here, we present the complete genome sequences of mycoplasma pneumoniae kch-402 and kch-405, which are p1 gene type 2b and 2c strains, respectively. these strains harbor variations in the orf6 gene, which encodes the cytadherence-related proteins p40 and p90. | 2017 | 28619800 |
| peculiar cold-induced leukoagglutination in mycoplasma pneumoniae pneumonia. | | 2017 | 28611012 |
| prevalence and clinical manifestations of macrolide resistant mycoplasma pneumoniae pneumonia in korean children. | macrolide resistance rate of mycoplasma pneumoniae has rapidly increased in children. studies on the clinical features between macrolide susceptible-m. pneumoniae (msmp) and macrolide resistant-m. pneumoniae (mrmp) are lacking. the aim of this study was to identify the macrolide resistance rate of m. pneumoniae in korean children with m. pneumoniae penupmonia in 2015 and compare manifestations between msmp and mrmp. | 2017 | 28592978 |
| radiologic findings as a determinant and no effect of macrolide resistance on clinical course of mycoplasma pneumoniae pneumonia. | with the emergence of macrolide resistance, concerns about the efficacy of macrolides for the treatment of mycoplasma pneumoniae (mp) pneumonia in children have been raised. this study aimed to determine the effect of macrolide resistance on the outcome of children who were hospitalized with mp pneumonia. | 2017 | 28592263 |
| killing kinetics of minocycline, doxycycline and tosufloxacin against macrolide-resistant mycoplasma pneumoniae. | macrolide-resistant mycoplasma pneumoniae (mrmp) has emerged and is increasing worldwide. in a 2011 outbreak of mrmp infections in japan, symptoms failed to improve in many patients who initially received macrolides; the therapeutic agent was then changed to minocycline (min), doxycycline (dox) or tosufloxacin (tfx). in this study, the bactericidal effects of these three agents against mrmp were evaluated. time-kill kinetics against mrmp and macrolide-susceptible m. pneumoniae (msmp) were determ ... | 2017 | 28579455 |
| association of mycoplasma pneumoniae infection with increased risk of asthma in children. | the present study was conducted to investigate the relationship between mycoplasma pneumoniae (mp) infection and the risk of asthma among children by detecting the rate of mp immunoglobulin m (mp-igm) and the eosinophil (eos) count. a total of 139 asthmatic children were enrolled as the case group and assigned into three groups: group a (aged <3 years, n=42), group b (aged 3-8 years, n=45) and group c (aged >8 years, n=52). additionally, 115 healthy children were enrolled in the control group. e ... | 2017 | 28565772 |
| fuchs syndrome: medical treatment of 1 case and literature review. | fuchs syndrome is a particular type of erythema multiforme major; the lesions are only found on the mucosae and specifically affect oral, ocular, and genital mucosae. the cause is not always immediately apparent, which is why this pathology requires a rigorous, detailed clinical examination to eliminate a differential diagnosis. the severity of the symptoms, particularly of oral and ocular symptoms, requires immediate treatment. the treatment of this pathology requires a multiple-drug regime. th ... | 2017 | 28559809 |
| mycoplasma pneumoniae-induced rash and mucositis (mirm): an unusual mild skin rash associated with severe mucosal involvement. | | 2017 | 28551607 |
| whole genome analysis reveals new insights into macrolide resistance in mycoplasma pneumoniae. | mutations in 23s rrna gene are known to be associated with macrolide resistance in mycoplasma pneumoniae (m. pneumoniae). however, these mutations alone do not fully explain the high resistance rates in asia. the aim of this study was to investigate other possible mutations involved in macrolide resistance in m. pneumoniae. | 2017 | 28549490 |
| mycoplasma pneumoniae from the respiratory tract and beyond. | mycoplasma pneumoniae is an important cause of respiratory tract infections in children as well as adults that can range in severity from mild to life-threatening. over the past several years there has been much new information published concerning infections caused by this organism. new molecular-based tests for m. pneumoniae detection are now commercially available in the united states, and advances in molecular typing systems have enhanced understanding of the epidemiology of infections. more ... | 2017 | 28539503 |
| evaluation of a real-time method of simultaneous amplification and testing in diagnosis of mycoplasma pneumoniae infection in children with pneumonia. | mycoplasma pneumoniae (m. pneumoniae) infection can cause community acquired pneumonia in children. a real-time method of simultaneous amplification and testing of m. pneumoniae (sat-mp) was developed to diagnose m. pneumoniae targeting a region of the ribosomal rna. the sat-mp assay can accurately identify m. pneumoniae with a detection range from 101 to 107 cfu/ml. in this study, the specimens from 315 children with pneumonia were collected and analyzed by sat-mp in parallel with real-time pcr ... | 2017 | 28520818 |
| delayed stevens-johnson syndrome secondary to the use of lamotrigine in bipolar mood disorder. | lamotrigine is a mood-stabilizing drug used in maintenance treatment of bipolar i disease. there are adverse effects with lamotrigine such as a headache, blurred vision, diplopia, somnolence, ataxia, dizziness, rash, stevens-johnson syndrome (sjs), and toxic epidermal necrolysis. sjs is a life-threatening, blistering mucocutaneous disease. sjs is characterized by the presence of flat, diffuse erythematous maculopapular rashes with the involvement of <10% of the body surface area. standard trigge ... | 2017 | 28515564 |
| histological findings in severe mycoplasma pneumoniae pneumonia. | | 2017 | 28513419 |
| encephalopathy and axonal neuropathy associated with mycoplasma pneumoniae infection: response to intravenous immunoglobulin therapy. | mycoplasma pneumoniae infection frequently presents as a self-limited process, however, severe cases and even fatalities have been reported. the authors present a case of mycoplasma pneumoniae infection associated with both encephalopathy and peripheral neuropathy that responded to intravenous immunoglobulin therapy. to our knowledge, this is the first documented case of mycoplasma pneumoniae related to encephalitis and peripheral axonal neuropathy. to date, there is insufficient data on the eff ... | 2017 | 28503607 |
| macrolide resistance and its impacts on m. pneumoniae pneumonia in children: comparison of two recent epidemics in korea. | the aim of this study was to investigate the change in macrolide resistance rate in pediatric mycoplasma pneumoniae pneumonia and to evaluate the influence of macrolide-resistant m. pneumoniae (mrmp) on the clinical course of disease, by comparing 2 recent, consecutive epidemics in korea. | 2017 | 28497921 |
| versatile methodology for glycosurfaces: direct ligation of nonderivatized reducing saccharides to poly(pentafluorophenyl acrylate) grafted surfaces via hydrazide conjugation. | in this work, we report a convenient and versatile strategy for surface-grafted glycopolymer constructs with the goal of surface modification that controls the chemical presentation and grafting density of carbohydrate side chains. this approach employs a difunctional hydrazine linker, chemically modified to an active ester containing poly(pentafluorophenyl acrylate) grafted scaffold, to conjugate a variety of saccharides through the reducing end. the successive conjugation steps are carried out ... | 2017 | 28492327 |
| the seroprevalence of mycoplasma pneumoniae igm and igg antibodies in patients with ischemic stroke. | association between mycoplasma pneumoniae infection and increased risk for brain stroke has been well understood. hence, the value of serologic tests for assessing causative relationship between this infection and brain stroke seems to be high. the present study aimed to determine serum level of anti-mycoplasma pneumoniae antibodies in patients with brain stroke and to compare it with non-stroke patients. | 2016 | 28491249 |
| molecular characterization of mycoplasma pneumoniae infections in two rural populations of thailand from 2009 to 2012. | studies on mycoplasma pneumoniae in thailand have focused on urban centers and have not included molecular characterization. in an attempt to provide a more comprehensive understanding of this organism, we conducted a systematic random sampling to identify 3,000 nasopharyngeal swab specimens collected from january 2009 through july 2012 during population-based surveillance for influenza-like illness in two rural provinces. m. pneumoniae was detected by real-time pcr in 175 (5.8%) specimens. geno ... | 2017 | 28490485 |
| mycoplasma pneumoniae: a cross-sectional population-based comparison of disease severity in pre-school and school-age children. | mycoplasma pneumoniae (mp) causes epidemics of upper respiratory disease and pneumonia. it is thought that mp usually causes milder upper respiratory disease in pre-school children, with a greater chance of pneumonia in school-age children. in this population-based cross-sectional study, we present evidence that severe mp infection is more common in pre-school children than previously thought. | 2017 | 28471864 |
| nrf2 regulates the inflammatory response, including heme oxygenase-1 induction, by mycoplasma pneumoniae lipid-associated membrane proteins in thp-1 cells. | a series of inflammatory responses caused by mycoplasma pneumoniae largely depend on the lipid-associated membrane proteins (lamps). nuclear factor e2-related factor 2 (nrf2), a transcription factor, is considered to be a critical modulator of inflammatory responses and cellular redox homeostasis. monocytes play an important role in the invasion and immunity to resist pathogens. here, we investigated the role of nrf2 in the anti-inflammatory response stimulated by lamps using the human monocyte ... | 2017 | 28430965 |
| an interesting case of mycoplasma pneumonia associated multisystem involvement and diffuse alveolar hemorrhage. | severe mycoplasma pneumonia is a rare entity with only 0.5-2% of cases having a fulminant course. we present a 74-year-old woman with hypertension, diabetes mellitus and remote history of marginal zone b-cell lymphoma admitted with abdominal pain and diarrhea of 1-2 days associated with body-aches, dyspnea, dry cough and weight loss for 2-3 weeks. on physical exam, she was febrile, tachypneic, tachycardic and hypoxic on room air. chest examination revealed diffuse crackles and end-expiratory whe ... | 2017 | 28413775 |
| comprehensive bioinformatics analysis of mycoplasma pneumoniae genomes to investigate underlying population structure and type-specific determinants. | mycoplasma pneumoniae is a significant cause of respiratory illness worldwide. despite a minimal and highly conserved genome, genetic diversity within the species may impact disease. we performed whole genome sequencing (wgs) analysis of 107 m. pneumoniae isolates, including 67 newly sequenced using the pacific biosciences rs ii and/or illumina miseq sequencing platforms. comparative genomic analysis of 107 genomes revealed >3,000 single nucleotide polymorphisms (snps) in total, including 520 ty ... | 2017 | 28410368 |
| association of the ace, gstm1, il-6, nos3, and cyp1a1 polymorphisms with susceptibility of mycoplasma pneumoniae pneumonia in chinese children. | mycoplasma pneumoniae is a common cause of community-acquired pneumonia (cap) and the clinical presentation of mycoplasma pneumoniae pneumonia (mpp) varies widely. genetic variability affecting the host response may also influence the susceptibility to mpp. several studies have investigated the association between single nucleotide polymorphism (snp) of some genes and the risks of cap; however, the results were inconsistent. here, we investigated the association of 5 functional genes and the ris ... | 2017 | 28403117 |
| prevalence of mycoplasma pneumoniae infection in malagasy children. | childhood community-acquired pneumonia is a leading cause of childhood morbidity in low-income countries. the etiologic agents are usually staphylococcus aureus, streptococcus pneumoniae and mycoplasma pneumoniae. m. pneumoniae was recognized as a cofactor in asthmatic disease. high asthma prevalence was reported in madagascar. our aim was to clarify the prevalence of m. pneumoniae infection in this country and its relationship with asthma. | 2017 | 28403048 |
| mycoplasma pneumoniae as a cause of the 'fever of unknown origin' syndrome. | | 1982 | 28787486 |