| distribution of human papillomavirus types in women from valencia, spain, with abnormal cytology. | to determine human papillomavirus (hpv) types among cervical smears using polymerase chain reaction (pcr) and to contribute to the knowledge of human papillomavirus genotype distribution and prevalence of oncogenic types in cervical lesions in spain. | 2010 | 20391971 |
| association of schistosoma haematobium and human papillomavirus in cervical cancer: a case report. | the association between schistosoma haematobium and cervical cancer has been reported for a long time. however, recently human papillomavirus, a cofactor in the genesis of cervical cancer, has been confirmed. a case of squamous intraepithelial lesion after s haematobium infection is presented, and the relation between schistosomiasis, human papillomavirus and squamous intraepithelial lesion, with long-term follow-up by papanicolaou smear, is discussed. | 2010 | 20391981 |
| human papillomavirus transmission and cost-effectiveness of introducing quadrivalent hpv vaccination in denmark. | the objective of this study was to simulate human papillomavirus (hpv) infection in a heterosexual population and subsequently analyze the incremental costs and effects of introducing a vaccination program against hpv types 6, 11, 16, and 18 in denmark compared with screening alone. | 2010 | 20392322 |
| association of viral load with hpv16 positive cervical cancer pathogenesis: causal relevance in isolates harboring intact viral e2 gene. | we tested the hypothesis that cervical cancers (cacx) harbor high hpv16 viral load compared to controls and this is influenced by e2 status and age of subjects. viral load (natural log transformed values) per 100ng genomic dna was estimated (152 cases and 87 controls) by taqman assay. median viral load was significantly higher (mann-whitney u test) among cases (17.21) compared to controls (9.86), irrespective of e2 status or upon considering e2 status as a covariate in logistic regression model ... | 2010 | 20394955 |
| rescue of p53 function by small-molecule rita in cervical carcinoma by blocking e6-mediated degradation. | proteasomal degradation of p53 by human papilloma virus (hpv) e6 oncoprotein plays a pivotal role in the survival of cervical carcinoma cells. abrogation of hpv-e6-dependent p53 destruction can therefore be a good strategy to combat cervical carcinomas. here, we show that a small-molecule reactivation of p53 and induction of tumor cell apoptosis (rita) is able to induce the accumulation of p53 and rescue its tumor suppressor function in cells containing high-risk hpv16 and hpv18 by inhibiting hp ... | 2010 | 20395210 |
| tobacco and alcohol use increases the risk of both hpv-associated and hpv-independent head and neck cancers. | tobacco, alcohol, and human papillomavirus (hpv) are major risk factors for head and neck cancer (hnc), but it is unclear whether there are two distinct hnc risk groups, one associated with hpv and the other with tobacco/alcohol. because hpv-positive hnc are clinically distinct from hpv-negative cases in treatment response and with more favorable prognoses, determining whether these differences result from infection alone or in association with other hnc risk factors is important for developing ... | 2010 | 20401530 |
| hpv dna is associated with a subset of schneiderian papillomas but does not correlate with p16(ink4a) immunoreactivity. | this study investigated the role of human papillomavirus (hpv) in schneiderian papillomas (sps) to determine whether hpv is associated with the pathogenesis of particular histologic subtypes and whether p16(ink4a) can be used as a surrogate marker for hpv detection. twenty-seven papilloma specimens (19 inverted [ips], 6 exophytic [eps], 1 oncocytic [op] and 1 mixed) were collected from 23 patients. purified sp dna extracts were tested for hpv by pcr using gp5 +/gp6 + primers; hpv genotyping was ... | 2010 | 20405251 |
| regulation of mcp-1 chemokine transcription by p53. | our previous studies showed that the expression of the monocyte-chemoattractant protein (mcp)-1, a chemokine, which triggers the infiltration and activation of cells of the monocyte-macrophage lineage, is abrogated in human papillomavirus (hpv)-positive premalignant and malignant cells. in silico analysis of the mcp-1 upstream region proposed a putative p53 binding side about 2.5 kb upstream of the transcriptional start. the aim of this study is to monitor a physiological role of p53 in this pro ... | 2010 | 20406462 |
| 4-1bb ligand as an effective multifunctional immunomodulator and antigen delivery vehicle for the development of therapeutic cancer vaccines. | therapeutic subunit vaccines based on tumor-associated antigens (taa) represent an attractive approach for the treatment of cancer. however, poor immunogenicity of taas requires potent adjuvants for therapeutic efficacy. we recently proposed the tumor necrosis factor family costimulatory ligands as potential adjuvants for therapeutic vaccines and, hence, generated a soluble form of 4-1bbl chimeric with streptavidin (sa-4-1bbl) that has pleiotropic effects on cells of innate, adaptive, and regula ... | 2010 | 20406989 |
| is hpv-18 present in human breast cancer cell lines? | | 2010 | 20407441 |
| piwil2 expressed in various stages of cervical neoplasia is a potential complementary marker for p16. | generally, cancers may undergo the developmental stages of benign proliferation, precancer and invasive cancer. identification of biomarkers that are expressed throughout the developmental stages will facilitate detection, prevention and therapy of cancer. piwil2, a member of ago/piwi family of proteins, has been suggested to be associated with tumor development. here we reported that piwil2 can be detected by immunohistochemistry (ihc) in various stages of human cervical squamous cell carcinoma ... | 2010 | 20407605 |
| relevance of human papilloma virus (hpv) infection to carcinogenesis of oral tongue cancer. | human papilloma virus (hpv) infection is controversial as a causative factor in oral tongue cancer. this study aimed to clarify whether hpv directly affects the carcinogenesis and biological behaviour of oral tongue cancer by analyzing hpv prevalence, the physical status of the virus and clinicopathological parameters. archival tissue was obtained from 36 patients diagnosed with t1 and t2 oral tongue cancer and 25 normal controls. hpv genotyping chip and real-time polymerase chain reaction were ... | 2010 | 20413270 |
| [rna interference: biogenesis molecular mechanisms and its applications in cervical cancer]. | rnai (rna interference) is a natural process by which eukaryotic cells silence gene expression through small interference rnas (sirna) which are complementary to messenger rna (mrna). in this process, the sirna that are 21-25 nucleotides long and are known as microrna (mirna), either associate with the rna-induced silencing complex (risc), which targets and cleaves the complementary mrnas by the endonucleolytic pathway, or repress the translation. it is also possible to silence exogenous gene ex ... | 2010 | 20415061 |
| deregulation of stat-5 isoforms in the development of hpv-mediated cervical carcinogenesis. | cervical cancer is the second most common cancer and is leading cause of cancer related deaths in women worldwide. high risk-human papillomavirus (hpv) types play an important role in cervical carcinogenesis. considering the important role of signal transducer and activator of transcription-5 (stat-5), an important member of jak/stat family which plays a crucial role in various cancers and hpv as a key mediator in the development of cervical carcinogenesis, the purpose of the current study was t ... | 2010 | 20415542 |
| increased risk of hiv acquisition among kenyan men with human papillomavirus infection. | few data on the effect of human papillomavirus (hpv) infection on human immunodeficiency virus (hiv) acquisition are available. | 2010 | 20415595 |
| clonal status and clinicopathological observation of cervical minimal deviation adenocarcinoma. | minimal deviation adenocarcinoma (mda) of the uterine cervix is defined as an extremely well differentiated variant of cervical adenocarcinoma, with well-formed glands that resemble benign glands but show distinct nuclear anaplasia or evidence of stromal invasion. thus, mda is difficult to differentiate from other cervical hyperplastic lesions. monoclonality is a major characteristic of most tumors, whereas normal tissue and reactive hyperplasia are polyclonal. | 2010 | 20416098 |
| significance of human papillomavirus genotyping with high-grade cervical intraepithelial neoplasia treated by a loop electrosurgical excision procedure. | this study was conducted to determine whether the human papillomavirus (hpv) genotype by the hpv dna chip test (hdc) is predictive of residual or recurrent high-grade cervical intraepithelial neoplasia (cin) 2-3 following a loop electrosurgical excision procedure (leep). | 2010 | 20417477 |
| what is the role of hpv typing in the united states now and in the next five years in a vaccinated population? | to review the current state of hpv typing of the vaccinated population in the united states and potential for typing of this population over the next 5 years. | 2010 | 20417957 |
| association between human papillomavirus infection and laryngeal squamous cell carcinoma. | the aim of this study was to compare the prevalence of human papillomavirus (hpv) infection in laryngeal squamous cell carcinoma using two methods: pcr-dna enzyme immunoassay (pcr/deia) and immunohistochemistry (ihc) for detection of hpv in specimens of laryngeal squamous cell carcinoma and to correlate the presence of hpv with the epidemiological and clinicopathological features of recurrence and survival. hpv dna was amplified from 93 paraffin-embedded laryngeal squamous cell carcinoma tissue ... | 2010 | 20419817 |
| [factors associated with abnormal cervical cytology in pregnant women]. | to investigate the risk factors associated with abnormal cervical cytology findings in pregnant women. | 2010 | 20420780 |
| lymphoepithelial-like carcinoma of the oropharynx: a morphologic variant of hpv-related head and neck carcinoma. | human papillomavirus-associated squamous cell cancer of the head and neck (hpv-hnscc) represents an important subgroup of head and neck cancer that is characterized by distinct epidemiologic, clinical, and pathologic features including a relatively constant microscopic appearance. for those cancers that deviate from the morphologic prototype, an association with hpv may not be recognized and accurate tumor classification may not be achieved. we have identified 22 cases of hpv-hnscc with well-dev ... | 2010 | 20421782 |
| high prevalence and low e6 genetic variability of human papillomavirus 58 in women with cervical cancer and precursor lesions in southeast mexico. | infection with some genotypes of human papillomavirus (hpv) is the most important risk factor associated with cervical cancer (cc). throughout the world, hpv type 58 prevalence varies from one region to another; it is higher in women from certain countries in asia and latin america, such as china and mexico. although intratypic variants have been reported on a few occasions, our knowledge about hpv 58 genetic variation remains limited. therefore, this work aims to (i) determine the prevalence of ... | 2010 | 20428672 |
| e6/e7 mrna expression analysis: a test for the objective assessment of cervical adenocarcinoma in clinical prognostic procedure. | detection of e6/e7 mrna expression using the real-time nucleic acid sequence-based amplification assay (nasba) pretect hpv-proofer was compared with results of human papillomavirus (hpv) dna detection in 98 paraffin-embedded samples from patients with cervical adenocarcinoma. hr-hpv dna was detected in 61 (62%), while hr-hpv e6/e7 mrna was detected in 63 (64%) of the samples. correlation between results from dna analyses and the e6/e7 mrna assay showed consistent results in 87% of samples (47 of ... | 2010 | 20428778 |
| estimating clinical outcome of hpv induced cervical lesions by combination of capsid protein l1 and p16ink4a protein detection. | the aim of this study was to investigate whether is possible to predict clinical outcome of cervical lesion by immunoassaying performed on cervical smears. during the two year study period the cervical smears of 81 patients were collected. all patients were tested for human papillomavirus (hpv) infections using amplycor hpv test. sixty-six of them were tested as positive for high risk types (hrhpv) and squamous intraepithelial lesion, and in those patients repeated cervical smears were taken eve ... | 2010 | 20432730 |
| detection of human papillomaviruses type 16, 18 and 33 in bronchial aspirates of lung carcinoma patients by polymerase chain reaction: a study of 84 cases in croatia. | besides its well-known role in cervical carcinoma, hpv is also suggested to be involved in lung cancer development. a number of authors have been investigating the presence of hpv in histological materials. we used routine bronchial aspirates from 84 patients with lung carcinoma for dna extraction and then performed polymerase chain reaction for high-risk hpv types 16, 18 and 33. the results were compared to those obtained from buccal and eyelid mucosa. only three patients were positive for hpv ... | 2010 | 20432745 |
| human papillomavirus and cervical cancer: gardasil vaccination status and knowledge amongst a nationally representative sample of australian secondary school students. | the aim of this paper was to measure student knowledge of hpv and risks associated with cervical cancer, explore associated factors, correlate knowledge of hpv and cervical cancer with other domains of sexual health related knowledge and estimate student self-reported rates of hpv immunisation. data were from a nationally representative cross-sectional stratified cluster sample of year 10 and 12 students in the australian secondary school system. contingency table, comparison of means, correlati ... | 2010 | 20434543 |
| vaccination with multimeric l2 fusion protein and l1 vlp or capsomeres to broaden protection against hpv infection. | immunization with l1 as pentavalent capsomeres or virus-like particles (vlps) generates high and long-lived titers of neutralizing antibodies and protection primarily against the human papillomavirus (hpv) type from which the vaccine was derived. conversely, vaccination with l2 minor capsid protein derived from multiple hpv types induces lower titer, but more broadly neutralizing and protective antibody responses. we combined the advantages of each protective antigen by immunization with titrate ... | 2010 | 20434552 |
| role of t cell competition in the induction of cytotoxic t lymphocyte activity during viral vector-based immunization regimens. | t cell competition between antigen- and vector-specific t cells may determine the outcome of viral vector-based immunization regimens, as we previously proposed. here, we unravelled the interplay between antigen- and vector-specific immunity, using recombinant semliki forest virus (rsfv). priming of mice with rsfv, encoding lacz (sfvlacz), or with empty rsfv strongly suppressed subsequent induction of ovalbumin or human papilloma virus (hpv) e6/e7-specific ctl activity by a booster with sfveova ... | 2010 | 20434555 |
| the japanese guideline for cervical cancer screening. | cervical cancer is the 11th leading cause of death from cancer for females in japan. in 2005, there were 2486 deaths from cervical cancer, accounting for 1.8% of the total number of cancer deaths in japan. cervical cancer screening using conventional cytology has been conducted worldwide. the guideline for cervical cancer screening was developed based on the established method. the efficacies of conventional and liquid-based cytology, human papillomavirus testing alone and two combination method ... | 2010 | 20436034 |
| management of anal squamous intraepithelial lesions. | anal squamous intraepithelial lesions include both low-grade squamous intraepithelial lesions (lsil) and high-grade squamous intraepithelial lesions (hsil) and are caused by chronic infection with the human papillomavirus (hpv). the disease is increasing in both incidence and prevalence, especially among patients with the following risk factors: homosexual men, acquired or iatrogenic immunosuppression, and presence of other hpv-related diseases. although the natural history of the disease is unk ... | 2009 | 20436833 |
| clinical trials in the management of anal cancer. | our understandings of anal canal cancer pathogenesis and treatment have undergone significant changes due to continuing research into its pathogenesis and the results of major clinical trials conducted over the past 20 years. anal canal cancer can be cured by combined modality chemoradiation therapy, a treatment that preserves continence and reserves abdominoperineal resection of the rectum and anal canal in patients with recurrent or residual disease after primary chemoradiotherapy. the researc ... | 2009 | 20436836 |
| factors related to physicians' willingness to vaccinate girls against hpv: the importance of subjective norms and perceived behavioral control. | this study assessed factors related to physicians' intentions to vaccinate patients against human papillomavirus. a random sample of physicians was surveyed. the survey questions focused on the constructs of the theory of planned behavior. structural equation modeling was used to estimate the relationship of theoretical constructs to intention to vaccinate. of the 207 physicians who responded, intentions to vaccinate were very high (86.5%). on a scale of 1 to 7 (strongly disagree to strongly agr ... | 2010 | 20437302 |
| [screening of cervical cancer--update]. | update screening of cervical cancer. | 2010 | 20437841 |
| safety, tolerability, and immunogenicity of gardasil given concomitantly with menactra and adacel. | multinational phase iii trials of a human papillomavirus vaccine, gardasil, have shown the vaccine to be generally well-tolerated, efficacious, and immunogenic. we evaluated the immunogenicity and safety of gardasil administered concomitantly with menactra and adacel. | 2010 | 20439595 |
| reduced mir-34a expression in normal cervical tissues and cervical lesions with high-risk human papillomavirus infection. | reduced mir-34a expression is associated with high-risk human papillomavirus (hr-hpv) infection and cervical cancer. whether the reduction of mir-34a expression induced by hr-hpv e6 occurs in precancerous lesions, even before morphologic change, is still uncertain. our study aimed to ascertain the possibility of pri-mir-34a involved in the development of cervical lesions and to explore the mechanism of altered pri-mir-34a expression induced by hpv-16 e6. | 2010 | 20442590 |
| the role of cytology (pap tests) and human papillomavirus testing in anal cancer screening. | to assess anal oncogenic human papillomavirus (hpv) and anal cytology as screening tests for detecting high-grade anal intraepithelial neoplasia (ain 2+), as this is an immediate anal cancer precursor. | 2010 | 20442633 |
| identification of human papilloma virus type 6 in psoriasiform keratosis. | psoriasiform keratosis is a recently reported unique clinicopathological entity characterized by the appearance of a solitary lesion mimicking seborrheic keratosis, actinic keratosis, or squamous cell carcinoma and histopathologic features closely resembling psoriasis. we report a 74-year-old woman presenting with a solitary, scaly lesion on the dorsum of the left arm of several months duration and histopathologic findings of psoriasiform acanthosis of the epidermis with thinning of the suprapap ... | 2010 | 20442638 |
| natural history of infections with high-risk hpv in chinese women with abnormal cervical cytology findings at baseline. | to clarify the natural history of disease in chinese women with benign cytologic observation and positive for high-risk human papillomavirus (hr-hpv). | 2010 | 20447633 |
| detection of polyomavirus major capsid antigen (vp-1) in human pilomatricomas. | the family polyomaviridae is composed of small, non-enveloped, double-stranded dna viruses widely used to study cell transformation in vitro and tumor induction in vivo. the development of pilomatricomas in mice experimentally infected with polyomavirus led us to detect the viral major capsid protein vp-1 in human pilomatricomas. this tumor, even uncommon, is one of the most frequent benign hair follicle tumors in humans and is composed of proliferating matrix cells that undergo keratinization, ... | 2010 | 20447899 |
| hpv-associated head and neck cancer: a virus-related cancer epidemic. | a rise in incidence of oropharyngeal squamous cell cancer--specifically of the lingual and palatine tonsils--in white men younger than age 50 years who have no history of alcohol or tobacco use has been recorded over the past decade. this malignant disease is associated with human papillomavirus (hpv) 16 infection. the biology of hpv-positive oropharyngeal cancer is distinct with p53 degradation, retinoblastoma rb pathway inactivation, and p16 upregulation. by contrast, tobacco-related oropharyn ... | 2010 | 20451455 |
| attitudes and perceptions of the hpv vaccine in caribbean and african-american adolescent girls and their parents. | to describe attitudes and perceptions toward acceptability of human papilloma virus (hpv) vaccination among inner city caribbean (ca) and african american (aa) adolescents and their parents, and discuss correlates that may be associated with these factors. | 2010 | 20452260 |
| [increasing incidence of anal cancer in the netherlands]. | anal cancer is a rare malignancy with a rapidly rising incidence. the most important risk factor for anal cancer is persistent infection with human papillomavirus (hpv). in the netherlands, the incidence of anal cancer increased from 71 to 149 new patients each year over the period 1989-2006. there has been a corresponding overall increase in mortality, although the exact level differs per year. not enough research has been done to date to clarify why the incidence of anal cancer is increasing. | 2010 | 20456793 |
| estrogen and eralpha: culprits in cervical cancer? | estrogen and its receptors are implicated in the promotion and prevention of various cancers. although the uterine cervix is highly responsive to estrogen, the role of estrogen in cervical cancer, which is strongly associated with human papillomavirus (hpv) infections, is poorly understood. recent studies in hpv transgenic mouse models provide evidence that estrogen and its nuclear receptor promote cervical cancer in combination with hpv oncogenes. although epidemiological studies further suppor ... | 2010 | 20456973 |
| spectral clustering of microarray data elucidates the roles of microenvironment remodeling and immune responses in survival of head and neck squamous cell carcinoma. | to identify functionally related prognostic gene sets for head and neck squamous cell carcinoma (hnscc) by unsupervised statistical analysis of microarray data. | 2010 | 20458058 |
| clinical study of quantitative diagnosis of early cervical cancer based on the classification of acetowhitening kinetics. | a quantitative colposcopic imaging system for the diagnosis of early cervical cancer is evaluated in a clinical study. this imaging technology based on 3-d active stereo vision and motion tracking extracts diagnostic information from the kinetics of acetowhitening process measured from the cervix of human subjects in vivo. acetowhitening kinetics measured from 137 cervical sites of 57 subjects are analyzed and classified using multivariate statistical algorithms. cross-validation methods are use ... | 2010 | 20459246 |
| nucleic acid sequence-based amplification assay for human papillomavirus mrna detection and typing: evidence for dna amplification. | human papillomavirus (hpv) e6/e7 mrna has been proposed as a more specific marker for cervical dysplasia and cancer than hpv dna. this study evaluated the rna specificity of nucleic acid sequence-based amplification (nasba)-based hpv detection using hpv dna plasmids (hpv type 16 [hpv16], hpv18, hpv31, hpv33, and hpv45) and nucleic acid extracts of several cell lines, which were systematically subjected to enzymatic treatments with dnase and rnase. hpv plasmid dilutions (10(6) to 10(0) copies/mic ... | 2010 | 20463156 |
| [methods used in the identification of human papillomavirus]. | given the causal relationship between specific types of hpv with cervical cancer and precursor lesions, it is important to identify the viral type involved. the characterization is done by various methods that vary in sensitivity and specificity, whose use depends mainly on the aim pursued and the characteristics of the evaluated sample. hpv typing is not only important clinically for the establishment of monitoring and treatment of a patient, it also provides knowledge of the viral types circul ... | 2010 | 20463773 |
| management of anal cancer in 2010. part 1: overview, screening, and diagnosis. | although anal cancer is a rare disease, its incidence is increasing in men and women worldwide. the most important risk factors are behaviors that predispose individuals to human papillomavirus (hpv) infection or immunosuppression. anal cancer is generally preceded by high-grade anal intraepithelial neoplasia (hgain), which is most prevalent in human immunodeficiency virus (hiv)-positive men who have sex with men. there is a general consensus that high-risk individuals may benefit from screening ... | 2010 | 20464850 |
| population fraction of cervical neoplasia attributable to high-risk human papillomaviruses. | the efficacy of human papillomavirus (hpv) type 16 and 18 vaccines against cervical intraepithelial neoplasia grade ii (cin2+) has been verified, but the active follow-up of studies with invasive cervical cancer or cervical intraepithelial neoplasia grade iii (cin3) as primary end points are ethically not possible. furthermore, ongoing registry-based passive follow-up studies with invasive cervical cancer as the end point will take time. | 2010 | 20465386 |
| [condylomatous cell carcinoma of the penis associated with multimetastatic human papillomavirus]. | | 2010 | 20470704 |
| why do low-income minority parents choose human papillomavirus vaccination for their daughters? | to explore low-income minority parents' attitudes, intentions, and actions with regard to human papillomavirus (hpv) vaccination for their daughters. | 2010 | 20472250 |
| determinants of human papillomavirus infection among inuit women of northern quebec, canada. | we investigated risk factors for prevalent high-risk human papillomavirus (hr-hpv) in inuit women from quebec. younger age and having 10 or more lifetime sexual partners were associated with hr-hpv. findings suggest that for older women, markers of recent sexual activity are more predictive of hr-hpv status than markers of lifetime sexual history. | 2010 | 20473246 |
| association between toll-like receptor expression and human papillomavirus type 16 persistence. | the mechanisms involved in mucosal immune control of cervical human papillomavirus (hpv) infection remain ill defined. because toll-like receptors (tlrs) are key players in innate immune responses, we investigated the association between tlr expression and viral persistence or clearance in young women with incident infections with oncogenic hpv types 16 or 51. messenger rna expression of tlr1, tlr2, tlr3, tlr4, tlr6, tlr7, tlr8 and tlr9 was measured by quantitative reverse transcription-pcr usin ... | 2011 | 20473890 |
| nf-κ b-dependent upregulation of icam-1 by hpv16-e6/e7 facilitates nk cell/target cell interaction. | nk cell recognition of tumor cells is mediated by a delicate balance of signals received by mhc class i-binding inhibitory nk cell receptors and activating nk cell receptors, which mainly bind to virus-, stress- or tumor-induced ligands. in addition, adhesion molecules such as the intercellular adhesion molecule-1 (icam-1) and its receptors, the lymphocyte function-associated antigen-1 (lfa-1) and mac-1, are crucial for immune synapse formation and nk cell-mediated killing. in this study, we sho ... | 2011 | 20473930 |
| a tritherapy combination of a fusion protein vaccine with immune-modulating doses of sequential chemotherapies in an optimized regimen completely eradicates large tumors in mice. | tumor-induced immunosuppression plays a critical role in both impeding tumor-specific immune responses and limiting the effects of cancer immunotherapy. analyses of regulatory cells recruited during the growth of the e7-expressing tumor, tc-1, revealed a high percentage of regulatory t cells (tregs) as well as myeloid-derived suppressor cells (mdscs) in spleens and tumors. in this study, we proposed that treatment with immune-modulating doses of cyclophosphamide (ctx) and all-trans retinoic acid ... | 2011 | 20473939 |
| prognostic impact of p16, p53, epidermal growth factor receptor, and human papillomavirus in oropharyngeal cancer in a betel nut-chewing area. | to evaluate the prevalence of human papillomavirus (hpv) and the prognostic significance of epidermal growth factor receptor (egfr), p53, and p16 among patients with oropharyngeal carcinoma. | 2010 | 20479383 |
| hiv-1 protease has a genetic t-cell adjuvant effect which is negatively regulated by proteolytic activity. | hiv protease (pr) mediates the processing of human immunodeficiency virus (hiv) polyproteins and is necessary for the viral production. recently, hiv pr was shown to possess both cytotoxic and chaperone like activity. we demonstrate here that hiv pr can serve as a genetic adjuvant that enhances the hiv env and human papillomavirus (hpv) dna vaccine-induced t-cell response in a dose-dependent manner, only when codelivered with dna vaccine. interestingly, the t-cell adjuvant effects of hiv pr were ... | 2010 | 20484507 |
| the spanish human papillomavirus vaccine consensus group: a working model. | successful implementation of human papillomavirus (hpv) vaccine in each country can only be achieved from a complementary and synergistic perspective, integrating all the different points of view of the diverse related professionals. it is this context where the spanish hpv vaccine consensus group (grupo español de consenso sobre la vacuna vph, gec-vph) was created. gec-vph philosophy, objectives and experience are reported in this article, with particular attention to the management of negative ... | 2010 | 20484987 |
| oral proliferative verrucous leukoplakia: underdiagnosed oral precursor lesion that requires retrospective clinicopathological correlation. | we present herein a case of oral proliferative verrucous leukoplakia (opvl) and discuss this relatively rare entity in light of current information. a 59-year-old woman, non-smoker, presented with a verrucous plaque at the left ventral and dorsal surfaces of the tongue that she had first noticed in 2001. at that time, the plaque was excised and revealed benign hyperkeratosis. the growth recurred and was again excised. histologically it was characterized by a verrucous epithelial hyperplasia, hyp ... | 2010 | 20492823 |
| immortalization of oral keratinocytes by functional inactivation of the p53 and prb pathways. | a subgroup of head and neck squamous cell carcinomas (hnsccs) contains high-risk human papillomavirus-type 16 (hpv16). the viral e6 and e7 oncoproteins inactivate the p53 and prb proteins, respectively. we examined the causative effect of hpv16 e6 and e7 expression on the immortalization of normal oral keratinocytes (okcs) and compared the resulting phenotype with alternative ways of p53- and prb-pathway abrogation frequently found in hnsccs without hpv. primary okcs were conditionally immortali ... | 2011 | 20499310 |
| efficacy of hpv 16/18 vaccines on sexually active young women and the impact on organized cervical cancer screening. | | 2010 | 20504086 |
| adult women's attitudes toward the hpv vaccine. | two human papillomavirus (hpv) vaccines have demonstrated efficacy in preventing hpv infection and are currently being administered to adolescent girls in several countries. although the most efficient hpv prevention strategy is immunizing adolescents before there is any risk of exposure, adult women also may benefit from vaccination. this study aimed to explore the attitudes of women aged 27-55 years toward the hpv vaccine. | 2010 | 20509785 |
| polymorphism of the capsid l1 gene of human papillomavirus types 31, 33, and 35. | the l1 gene encodes for the major capsid protein of human papillomaviruses (hpv). there is limited information on the polymorphism of l1 for types related to hpv-16. this report explores the polymorphism of l1 in phylogenetically related types 31, 33, and 35 compared to hpv-16. genital specimens collected from 732 hiv-seropositive and 323 hiv-seronegative women were screened for hpv dna with consensus l1 pcr. cervical samples positive for hpv-16 (n = 74), hpv-31 (n = 78), hpv-33 (n = 37), and hp ... | 2010 | 20513080 |
| awareness and knowledge about human papillomavirus among inuit women in nunavik, quebec. | accurate knowledge about human papillomavirus (hpv) and its link to cervical cancer is essential for women to understand and make use of cervical cancer prevention and detection opportunities. this study was the first to survey awareness and knowledge of hpv in a population of canadian inuit. the objectives of this study were to assess the level of awareness and knowledge of inuit women in nunavik, quebec, canada, about hpv infection and its relation to cervical cancer and to study correlates of ... | 2011 | 20517640 |
| age-specific hpv seroprevalence among young females in the netherlands. | to obtain insight into the age-specific seroprevalence for human papillomavirus (hpv) 6, 11, 16 and 18 among females before introduction of hpv vaccination in the netherlands. | 2010 | 20519252 |
| an infant presenting with a voluminous exophytic perineal mass. | | 2010 | 20524229 |
| p53 codon 72 and p21 codon 31 polymorphisms and susceptibility to cervical adenocarcinoma in korean women. | the aims of this study were to evaluate the genotype frequencies of p53 codon 72 and p21 codon 31 in cervical adenocarcinoma patients and controls, and the association between the specific genotype or genotype combination of these polymorphisms and the risk of cervical adenocarcinoma in korean women. genotyping was performed using dna from cervical biopsy specimens collected from 53 patients with cervical adenocarcinoma, of whom 34 were hpv 16 or 18 positive, and from the cervical exfoliated cel ... | 2010 | 20524403 |
| interleukin-10 production by tumor infiltrating macrophages plays a role in human papillomavirus 16 tumor growth. | human papillomavirus, hpv, is the main etiological factor for cervical cancer. different studies show that in women infected with hpv there is a positive correlation between lesion grade and number of infiltrating macrophages, as well as with il-10 higher expression. using a hpv16 associated tumor model in mice, tc-1, our laboratory has demonstrated that tumor infiltrating macrophages are m2-like, induce t cell regulatory phenotype and play an important role in tumor growth. m2 macrophages secre ... | 2010 | 20525400 |
| commentary: clinical nodal staging of human papillomavirus-related oropharyngeal cancer. | | 2010 | 20526107 |
| the effects of genital schistosoma haematobium on human papillomavirus and the development of cervical neoplasia after five years in a zimbabwean population. | high-risk human papillomavirus (hpv) is responsible for cervical cancer and genital schistosoma haematobium infection has been hypothesized to be an additional co-factor or even an independent risk factor for cervical neoplasia. the present study aimed to investigate the impact of schistosomiasis on hpv persistence and development of cell atypia in a group of rural zimbabwean women with confirmed high-risk hpv. | 2010 | 20527233 |
| epidemiological modelling of risk factors of human papilloma virus in women with positive cytology in the county of csongrád. | this study was carried out to determine the prevalence and risk factors of genital hpv infection in women diagnosed with non-negative cytology in southeastern hungary. cervical samples were collected for cytology and hpv testing from women seen at gynaecological outpatient clinics and diagnosed with non-negative cytology. the observed overall average hpv infection rate was found to be 61%. a smoking habit was the only risk factor in the logistic regression analysis that related significantly to ... | 2010 | 20527236 |
| assessment of the cost-effectiveness of a quadrivalent hpv vaccine in norway using a dynamic transmission model. | to assess the epidemiological and economic impact of alternative quadrivalent human papillomavirus (hpv) vaccine strategies in norway, we adapted a previously published dynamic transmission model. vaccination of girls and women aged 12-24 years reduced the incidence of hpv 6/11/16/18-related genital warts, cervical intraepithelial neoplasia and cervical cancer by 94, 92 and 92% by year 100, respectively. the cost-effectiveness ratio for this strategy when compared with vaccinating girls before t ... | 2008 | 20528334 |
| prevalence of human papillomavirus (hpv) in chinese patients with colorectal cancer. | abstract aim: the prevalence of human papillomavirus (hpv) was determined in chinese patients with colorectal cancer (crc). the study also aimed to determine whether hpv dna peripheral blood assay can be used to diagnose hpv-related crc. method: tumor tissue, non-cancerous colorectal tissue and whole blood samples were obtained from 96 crc patients. in addition, 32 colorectal tissue samples were harvested from patients without crc and 48 whole blood samples were collected from healthy blood dono ... | 2010 | 20528894 |
| hpv16 e2 is an immediate early marker of viral infection, preceding e7 expression in precursor structures of cervical carcinoma. | the viral e2 gene product plays a crucial role in the human papillomavirus (hpv) vegetative cycle by regulating both transcription and replication of the viral genome. e2 is a transcriptional repressor of the e6 and e7 viral oncogenes for hpv types 16 and 18, which are involved in cervical cancers. using new polyclonal antibodies against the hpv16 e2 protein, we showed that e2 is expressed at various precursor stages of cervical carcinoma by immunohistochemistry on paraffin-embedded clinical sam ... | 2010 | 20530671 |
| e6-associated protein is required for human papillomavirus type 16 e6 to cause cervical cancer in mice. | high-risk human papillomaviruses (hpv) cause certain anogenital and head and neck cancers. e6, one of three potent hpv oncogenes that contribute to the development of these malignancies, is a multifunctional protein with many biochemical activities. among these activities are its ability to bind and inactivate the cellular tumor suppressor p53, induce expression of telomerase, and bind to various other proteins, including bak, e6bp1, and e6tp1, and proteins that contain pdz domains, such as hscr ... | 2010 | 20530688 |
| who should get the hpv vaccine? usage expands amid debate. | | 2010 | 20530765 |
| htert promoter activity and cpg methylation in hpv-induced carcinogenesis. | activation of telomerase resulting from deregulated htert expression is a key event during high-risk human papillomavirus (hrhpv)-induced cervical carcinogenesis. in the present study we examined htert promoter activity and its relation to dna methylation as one of the potential mechanisms underlying deregulated htert transcription in hrhpv-transformed cells. | 2010 | 20534141 |
| perianal bowen disease in a child with human immunodeficiency virus. | individuals infected with the human immunodeficiency virus (hiv) are at increased risk for human papillomavirus (hpv)-related cancers of the anogenital region. a majority of these cancers have been reported in adult patients; few reports are available regarding anogenital hpv-associated carcinomas developing in children. we report a case of perianal bowen disease in an hiv-positive child. an 8-year-old hiv-positive boy with a history of perianal verrucous lesions presented to a clinic in lesotho ... | 2010 | 20537068 |
| relationships between epidermal growth factor receptor expression and human papillomavirus status as markers of prognosis in oropharyngeal cancer. | this study examines the prognostic significance of epidermal growth factor receptor (egfr) expression in relation to human papillomavirus (hpv) status in oropharyngeal squamous cell carcinoma (scc). | 2010 | 20537890 |
| acr appropriateness criteria: local-regional therapy for resectable oropharyngeal squamous cell carcinomas. | the optimal management of resectable oropharyngeal squamous cell carcinomas is controversial with many treatment options, both surgical and nonsurgical approaches, supported by published experiences with no randomized trials comparing commonly accepted treatments. the treatment decisions are further complicated by the need for local-regional disease control and competing goals to preserve salivary and swallow function. treatment decisions may also be affected by tumor and patient related factors ... | 2010 | 20541056 |
| carrageenan as an adjuvant to enhance peptide-based vaccine potency. | new innovative therapies are urgently required in order to combat the high mortality and morbidity associated with advanced cancers. antigen-specific cancer immunotherapy using peptide-based vaccination has emerged as an attractive approach for the control of cancers due to its simplicity and easy preparation. however, such an approach requires the employment of suitable adjuvants. in the current study, we explored the employment of a sulfated polysaccharide compound from red algae, carrageenan ... | 2010 | 20541583 |
| the isg15 conjugation system broadly targets newly synthesized proteins: implications for the antiviral function of isg15. | isg15 is an interferon-induced and antiviral ubiquitin-like protein (ubl). herc5, the major e3 enzyme for isg15, mediates the isgylation of more than 300 proteins in interferon-stimulated cells. in addressing this broad substrate selectivity of herc5, we found that: (1) the range of substrates extends even further and includes many exogenously expressed foreign proteins, (2) isg15 conjugation is restricted to newly synthesized pools of proteins, and (3) herc5 is physically associated with polyri ... | 2010 | 20542004 |
| external quality assessment for molecular detection of human papillomaviruses. | the united kingdom national external quality assessment service (uk neqas) distributes clinically relevant and educational specimens for external quality assessment (eqa). | 2010 | 20542463 |
| male circumcision to reduce sexual transmission of hiv. | three large trials among african heterosexual men in the last decade have confirmed that male circumcision reduces hiv acquisition. this review summarizes recent data regarding circumcision performed primarily to reduce hiv in high-prevalence settings. | 2010 | 20543611 |
| p16(ink4a) is superior to high-risk human papillomavirus testing in cervical cytology for the prediction of underlying high-grade dysplasia. | the primary goal of this study was to compare the clinical performance of an optimized and rigorously controlled immunocytochemical (icc) assay for p16(ink4a) to high-risk (hr) human papillomavirus (hpv) detection by polymerase chain reaction (pcr) as diagnostic adjuncts for cytology specimens from colposcopy patients. | 2010 | 20544710 |
| recurrent respiratory papillomatosis with malignant transformation. | | 2010 | 20546542 |
| human papillomavirus vaccination of males: attitudes and perceptions of physicians who vaccinate females. | we assessed u.s. physicians' attitudes and perceptions regarding potential human papillomavirus (hpv) vaccination of males. | 2010 | 20547286 |
| success or failure of vaccination for hpv16-positive vulvar lesions correlates with kinetics and phenotype of induced t-cell responses. | one half of a group of 20 patients with human papillomavirus type 16 (hpv16)-induced vulvar intraepithelial neoplasia grade 3 displayed a complete regression (cr) after therapeutic vaccination with hpv16 e6/e7 synthetic long peptides. patients with relatively larger lesions generally did not display a cr. to investigate immune correlates of treatment failure, patients were grouped according to median lesion size at study entry, and hpv16-specific immunity was analyzed at different time points by ... | 2010 | 20547850 |
| cervical cancer screening with both human papillomavirus and papanicolaou testing vs papanicolaou testing alone: what screening intervals are physicians recommending? | guidelines recommend screening for cervical cancer among women 30 years or older 3 years after a normal papanicolaou test (hereinafter referred to as pap test) result or a combined normal screening result (normal pap/negative human papillomavirus [hpv] test results). we assessed reported recommendations by us primary care physicians (pcps) on screening intervals that incorporate hpv cotesting compared with pap testing alone. | 2010 | 20548011 |
| the natural history of human papillomavirus infections of the mucosal epithelia. | human papillomaviruses (hpvs), members of a very large family of small dna viruses, cause both benign papillomas and malignant tumors. while most research on these viruses over the past 30 years has focused on their oncogenic properties in the genital tract, they also play an important role in diseases of the upper aerodigestive tract. rapidly accelerating advances in knowledge have increased our understanding of the biology of these viruses and this knowledge, in turn, is being applied to new a ... | 2010 | 20553526 |
| interaction of viral oncoproteins with cellular target molecules: infection with high-risk vs low-risk human papillomaviruses. | persistent infection by a subgroup of so-called high-risk human papillomaviruses (hpvs) that have a tropism for mucosal epithelia has been defined as the cause of more than 98% of cervical carcinomas as well as a high proportion of other cancers of the anogenital region. infection of squamous epithelial tissues in the head and neck region by these same high-risk hpvs is also associated with a subset of cancers. despite the general conservation of genetic structure amongst all hpv types, infectio ... | 2010 | 20553529 |
| high-throughput profiling of the humoral immune responses against thirteen human papillomavirus types by proteome microarrays. | we have developed microarrays with all eight proteins encoded by 13 different human papillomavirus types associated with anogenital cancer (hpv-16, -18, -31, -33, -35, -45, and -53), genital warts (hpv-6 and -11), or skin lesions (hpv-1, -2, -4, and -5). we analyzed the seroprevalence of antibodies in 546 patients, which had either cervical carcinomas, or precursor lesions, or which were asymptomatic. all patient groups contained sera ranging from high reactivity against multiple hpv proteins to ... | 2010 | 20554302 |
| mucosal delivery of human papillomavirus pseudovirus-encapsidated plasmids improves the potency of dna vaccination. | mucosal immunization may be important for protection against pathogens whose transmission and pathogenesis target the mucosal tissue. the capsid proteins of human papillomavirus (hpv) confer tropism for the basal epithelium and can encapsidate dna during self-assembly to form pseudovirions (psvs). therefore, we produced mucosal vaccine vectors by hpv psv encapsidation of dna plasmids expressing an experimental antigen derived from the m and m2 proteins of respiratory syncytial virus (rsv). intra ... | 2010 | 20555315 |
| perinatal outcomes in condyloma acuminata pregnancies. | to investigate pregnancy outcome in patients with condyloma acuminata. | 2011 | 20556405 |
| genotype-specific persistence of genital human papillomavirus (hpv) infections in women followed for 6 years in the finnish family hpv study. | persistent human papillomavirus (hpv) infection is the most important risk factor for cervical cancer, and understanding genotype-specific hpv persistence is essential for elucidating the natural history of hpv infections. | 2010 | 20557239 |
| primary squamous cell carcinoma of the endometrium. | a rare case of primary squamous cell carcinoma of the endometrium, probably originating from adenomyosis, is presented. a 58-year-old japanese woman was referred to kitasato institution medical center hospital to explore the cause of her postmenopausal bleeding. the endometrial cytology specimen obtained with the endocyte (an device for endometrial check up) showed cells suggesting well differentiated squamous cell carcinoma. the patient underwent modified radical hysterectomy, bilateral salping ... | 2000 | 20563701 |
| cigarette smoke condensate induces nuclear factor kappa-b activity and proangiogenic growth factors in aerodigestive cells. | aerodigestive cancer risk of both lung and head and neck cancers has been linked to the genotoxic effects of tobacco use. these effects include upregulation of nuclear factor kappa-b (nfkappab) and its downstream products associated with both lung and head and neck cancer malignant progression. | 2010 | 20564670 |
| [progress in the world and challenges in japan on hpv vaccination for cervical cancer prevention]. | for cervical cancer prevention, cervarix(hpv-16/18)was approvedin japan andvaccination programs against hpv-16/18 were startedin december, 2009. this vaccine is almost 100% effective in preventing high-grade precancer associated with the hpv types; it is safe and well tolerated. in japan, universal vaccination of females between 11 and 14 years is recommended. we all look forward to eradicating cervical cancer in the not too distant future. | 2010 | 20567096 |
| trends in cervical cancer incidence and mortality in the baltic countries, bulgaria and romania. | the burden of cervical cancer varies considerably in the european union (eu). in this article, we describe trends in incidence of and mortality from this cancer in the two most affected areas: the baltic countries (estonia, latvia and lithuania) and southeast europe (bulgaria and romania). incidence data were obtained from the national cancer registries. data on population and number of deaths from uterine cancers were extracted from the world health organization mortality database. mortality ra ... | 2011 | 20568103 |
| a case study: lessons learned from human papillomavirus vaccine development: approval of a vaccine for use in children and young adolescents for prevention of an adult disease. | this article presents the adolescent clinical trials program for the quadrivalent hpv vaccine (merck and co, inc, whitehouse station, nj) as a case study of the development of a preventive intervention for use in young adolescents to protect against a future sexually transmitted infection and its associated diseases. in light of similarities in human papillomavirus (hpv) and hiv with regard to sexual transmission and the associated social and ethical issues related to prevention trial developmen ... | 2010 | 20571424 |