| molecular characterizations of pcr-positive mycoplasma pneumoniae specimens collected from australia and china. | mycoplasma pneumoniae is an important cause of community-acquired pneumonia (cap). in this study, m. pneumoniae strains in pcr-positive specimens collected from patients in sydney, australia (30 samples), and beijing, china (83 samples), were characterized using multilocus variable-number tandem-repeat (vntr) analysis (mlva), p1-restriction fragment length polymorphism (rflp) analysis, and sequencing of domain v of the 23s rrna gene to compare genotype distribution and macrolide resistance rates ... | 2014 | 24574282 |
| meningoencephalitis-like onset of post-infectious aqp4-igg-positive optic neuritis complicated by gm1-igg-positive acute polyneuropathy. | fifteen days after a respiratory infection, a 45-year-old woman presented with paresthesias in the hands and feet, bilateral loss of vision, fever, headache, and impairment of consciousness. magnetic resonance imaging (mri) showed predominant lesions in the optic tracts, optic chiasm, and hypothalamus. cerebrospinal fluid analysis revealed elevated protein level, and lymphocytic pleocytosis. neurophysiological studies disclosed a demyelinating sensorimotor polyneuropathy. serum anti-mycoplasma p ... | 2015 | 24557856 |
| [clinical score to rule out pneumonia due to mycoplasma pneumoniae]. | the gold standard for the diagnosis of pneumonia secondary to mycoplasma pneumoniae is the serial measurement of igm, since an isolated test for igm has a poor sensitivity of 31.8%. a pneumonia due to mycoplasma pneumoniae could be of clinically different origins, thus it is possible to perform a clinical score for its early diagnosis. | 2014 | 24534005 |
| global secretome characterization of a549 human alveolar epithelial carcinoma cells during mycoplasma pneumoniae infection. | mycoplasma pneumoniae (m. pneumoniae) is one of the major etiological agents for community-acquired pneumonia (cap) in all age groups. the early host response to m. pneumoniae infection relies on the concerted release of proteins with various biological activities. however, no comprehensive analysis of the secretory proteins has been conducted to date regarding the host response upon m. pneumoniae infection. | 2014 | 24507763 |
| rapid detection of mycoplasma pneumoniae and its macrolide-resistance mutation by cycleave pcr. | mycoplasma pneumoniae is a common cause of community-acquired pneumonia, which is often empirically treated with macrolides such as erythromycin and azithromycin. recent studies have found a gradual increase in the numbers of macrolide-resistant strains due to mutations in the 23s rrna gene. a2063g is the most common mutation, followed by a2064g. we developed a cycleave pcr method for detecting macrolide-resistant strains of m. pneumoniae. with use of this method, the resistant strains can be qu ... | 2014 | 24503503 |
| [survey of macrolide resistance in mycoplasma pneumoniae in adult patients with community-acquired pneumonia in beijing, china]. | to explore the tendency of macrolide resistance in mycoplasma pneumoniae infection in community-acquired pneumonia (cap) patients in beijing. | 2013 | 24503430 |
| management of refractory mycoplasma pneumoniae pneumonia: utility of measuring serum lactate dehydrogenase level. | it has been suggested that cytokines are associated with refractory mycoplasma pneumoniae pneumonia, and steroid administration is reported to be effective in this situation. in order to elucidate the characteristics of refractory m. pneumoniae pneumonia, we analyzed five pediatric patients with refractory m. pneumoniae pneumonia, which was defined as showing prolonged fever and deterioration of clinical and radiological findings despite administration of appropriate antibiotics, compared with 1 ... | 2014 | 24486173 |
| in vitro spatial and temporal analysis of mycoplasma pneumoniae colonization of human airway epithelium. | mycoplasma pneumoniae is an important cause of respiratory disease, especially in school-age children and young adults. we employed normal human bronchial epithelial (nhbe) cells in air-liquid interface culture to study the interaction of m. pneumoniae with differentiated airway epithelium. these airway cells, when grown in air-liquid interface culture, polarize, form tight junctions, produce mucus, and develop ciliary function. we examined both qualitatively and quantitatively the role of mycop ... | 2014 | 24478073 |
| clinical features, risk factors and treatment of fulminant mycoplasma pneumoniae pneumonia: a review of the japanese literature. | mycoplasma pneumoniae (mp) is one of the most common causes of community-acquired pneumonia in children and young adults. although mp sometimes causes self-limiting pneumonia, severe and fulminant cases with hypoxia occur, but their clinical features have rarely been reported. this study aimed to reveal the clinical manifestations, risk factors, and treatment of fulminant mp pneumonia (mpp). using pubmed and abstracts from the proceedings of several domestic japanese academic societies, we revie ... | 2014 | 24462437 |
| a 3-year-old boy with guillain-barré syndrome and encephalitis associated with mycoplasma pneumoniae infection. | mycoplasma pneumoniae is a common cause of respiratory tract illness in children. among the most common extrapulmonary manifestations are disorders of the central nervous system, including meningitis, meningoencephalitis, cerebellitis, polyneuropathy, acute disseminated encephalomyelitis, and guillain-barré syndrome. guillain-barré syndrome, also known as acute inflammatory demyelinating polyradiculoneuropathy, is an acute-onset, immune-mediated disorder of the peripheral nervous system. the cen ... | 2014 | 24462436 |
| [diagnosis, treatment and prevention of infectious diseases. topics: i. countermeasures against epidemic infectious diseases: 4. macrolide-resistant mycoplasma pneumoniae]. | | 2013 | 24450118 |
| development of macrolide resistance in mycoplasma pneumoniae-infected swedish patients treated with macrolides. | the proportion of mycoplasma pneumoniae isolates carrying point mutations in the 23s region of the genome associated with macrolide resistance has increased. we evaluated the probability of developing m. pneumoniae macrolide resistance mutations during macrolide treatment. | 2014 | 24447251 |
| [the clinical characteristics, treatment and outcome of macrolide-resistant mycoplasma pneumoniae pneumonia in children]. | to investigate the drug resistance of mycoplasma pneumoniae among children with community-acquired pneumonia (cap), and to explore the clinical and radiological characteristics of and the role of azithromycin in the treatment of of macrolide-resistant (mr) mycoplasma pneumoniae pneumonia. | 2013 | 24433804 |
| comparison of the illumigene mycoplasma dna amplification assay and culture for detection of mycoplasma pneumoniae. | a loop-mediated isothermal amplification (lamp) system, the illumigene mycoplasma dna amplification assay (meridian bioscience, inc., cincinnati, oh) was evaluated to determine its analytical sensitivity, specificity, and clinical application in comparison to historic culture in a collection of archived respiratory specimens. the illumigene limit of detection was ≤88 cfu/reaction for 10 mycoplasma pneumoniae reference strains. this assay correctly identified 36 m. pneumoniae reference strains an ... | 2014 | 24430454 |
| the value of early diagnostic screens for the diagnosis of influenza a, b and mycoplasma pneumoniae infections. | rapid diagnosis of influenza virus and mycoplasma pneumoniae infections is of importance for therapeutic intervention. it was the aim of the study to evaluate screening tests for influenza a (flu a), b (flu b), and mycoplasma pneumoniae (m. pneumoniae) infections in young patients admitted to the hospital. | 2013 | 24409657 |
| [alterations of sp-a, sp-d and kl-6 in serum and bronchoalveolar lavage fluid in children with mycoplasma pneumoniae pneumonia]. | to study the alterations and relationship of surfactant protein (sp)-a, sp-d and kl-6 in serum and bronchoalveolar lavage fluids (balf) in children with mycoplasma pneumoniae pneumonia (mpp). | 2013 | 24406233 |
| [relationship between bronchoalveolar lavage mycoplasma load and clinical characteristics in children with mycoplasma pneumoniae pneumonia]. | mycoplasma pneumoniae (mp) is an important pathogen for community-acquired pneumonia in children. mp infection was considered to be self-limited, but many severe refractory mp pneumonia cases have been reported in recent years. the reason for variation in severity of mp pneumonia remains unclear. mp virulence including drug-resistance and host immunologic function are important influencing factors. the present study aimed to clarify relationship between local mp load and severity of mp pneumonia ... | 2013 | 24406224 |
| [rational management of refractory mycoplasma pneumoniae pneumonia]. | | 2013 | 24406222 |
| effects of methylprednisolone pulse therapy on refractory mycoplasma pneumoniae pneumonia in children. | mycoplasma pneumoniae (m. pneumoniae) is one of the most common causes of community-acquired pneumonia in children. the clinical course is typically self-limited and benign; however, rare cases of severe pneumonia can develop despite appropriate antibiotic therapy. we studied the effects of methylprednisolone pulse therapy on severe refractory m. pneumoniae pneumonia in children. | 2014 | 24404389 |
| characteristics of hospitalized children infected with macrolide-resistant mycoplasma pneumoniae. | the aim of this study was to clarify retrospectively the characteristics of children hospitalized for respiratory tract infection caused by macrolide-resistant mycoplasma pneumoniae (m. pneumoniae). | 2014 | 24389284 |
| co-infection with orientia tsutsugamushi and mycoplasma pneumoniae in a traveler. | | 2015 | 24388578 |
| a case of mycoplasma pneumoniae-associated encephalomyelitis in a 16-year-old female presenting to an adult teaching hospital. | we report a rare cause of encephalitis that is not often described in the adult clinical setting. our case was a 16-year-old female who presented with a clinical picture of viral encephalitis; however, magnetic resonance imaging showed a demyelinating lesion of the left frontal lobe. in this age group, differential diagnoses of acute demyelination encephalomyelitis and multiple sclerosis were entertained. further investigations demonstrated positive mycoplasma pneumoniae serology. as a result, a ... | 2013 | 24385717 |
| in children with respiratory symptoms are mycoplasma pneumoniae pcr and serology clinically significant? | | 2014 | 24385292 |
| respiratory syncytial virus infection in hospitalized children older than 2 years with community-acquired pneumonia. | respiratory syncytial virus (rsv) is one of the main causes of bronchiolitis and pneumonia in infants and young children. the aims of the present study were to evaluate the role of rsv in children >2 years old hospitalized with community-acquired pneumonia (cap) and to type the circulating rsv strains. | 2013 | 24376320 |
| effects of traditional chinese medicine qinbai qingfei concentrated pellet on cellular infectivity of mycoplasma pneumoniae. | aim. to study the effect and mechanism of traditional chinese medicine qinbai qingfei concentrated pellet (qqcp) against mycoplasma pneumoniae (mp). methods. rat airway smooth muscle (asm) cells were used to examine the antimycoplasmal activity of qqcp via four drug-adding modes: pre- and postadding drugs, simultaneous-adding after drug and mp mixed, and simultaneous-adding drug and mp; taking roxithromycin dispersive tablets (rdt) as positive control, the cellular a 570 values were determined b ... | 2014 | 27433528 |
| specific multilocus variable-number tandem-repeat analysis genotypes of mycoplasma pneumoniae are associated with diseases severity and macrolide susceptibility. | clinical relevance of multilocus variable-number tandem-repeat (vntr) analysis (mlva) in patients with community-acquired pneumonia (cap) by mycoplasma pneumoniae (m. pneumoniae) is unknown. a multi-center, prospective study was conducted from november 2010 to april 2012. nine hundred and fifty-four cap patients were consecutively enrolled. m. pneumoniae clinical isolates were obtained from throat swabs. mlva typing was applied to all isolates. comparison of pneumonia severity index (psi) and cl ... | 2013 | 24367502 |
| mycoplasma pneumoniae infections in childhood. | | 2014 | 24346598 |
| gene and cytokine profile analysis of macrolide-resistant mycoplasma pneumoniae infection in fukuoka, japan. | recent epidemiologic data suggest that the prevalence of macrolide resistant mycoplasma pneumoniae (mr-m. pneumoniae) is increasing rapidly worldwide. this study assessed the present status of m. pneumoniae infection in japan and clinical end-points to distinguish children with mr-m. pneumoniae. | 2013 | 24330612 |
| the emerging role of community sentinel surveillance in the understanding of the clinical features and epidemiology of acute mycoplasma pneumoniae infection. | retrospective analysis of 3984 test results for the detection of mycoplasma pneumoniae performed between 2009 and 2013 in wales was undertaken. analysis of the clinical presentation of positive cases suggested that mild respiratory infection was common in the community and appeared to coincide with increased hospitalizations. symptomatic infection was more prevalent in men, with a median age of 22.6 years (range <1-88 years), and 40% of hospitalized cases presented with pneumonia. inclusion of m ... | 2014 | 24330021 |
| [analysis of 11 cases of mycoplasma pneumoniae infection combined with kawasaki disease]. | to study the clinical characteristics of pediatric kawasaki disease complicating mycoplasma pneumoniae pneumonia. | 2013 | 24319959 |
| transient parkinsonism following mycoplasma pneumoniae infection with normal brain magnetic resonance imaging (mri). | parkinsonism caused by infection is uncommon in children. we report 2 previously healthy children with acute self-limiting parkinsonism following mycoplasma pneumoniae infection, with normal brain magnetic resonance imaging (mri). our case report expands the phenotype of parkinsonism associated with m. pneumoniae infection. we recommend that children with acute parkinsonism preceded by a period of febrile illness, even with a normal brain mri, should be investigated for m. pneumoniae infection. | 2014 | 24309239 |
| severe chest pain caused by mycoplasma myocarditis in an adolescent patient. | intermittent chest pain is a common symptom in adolescent patients, which can be attributed to musculoskeletal disorders in the majority of cases. while most patients have a benign course of their pain episodes, the differential diagnosis includes diseases which are associated with serious and even life-threatening complications. therefore, careful examination and systematic diagnostic evaluation is important. we report on an adolescent, who presented with severe chest pain and distinct electroc ... | 2013 | 24293079 |
| clinical features in guillain-barré syndrome with anti-gal-c antibody. | guillain-barré syndrome (gbs) has often been associated with antibodies to glycolipids, such as galactocerebroside (gal-c), a component of myelin. whether patients who have gbs with anti-gal-c antibody (gal-c-gbs) more often have demyelinating neuropathy or axonal neuropathy remains controversial. their clinical features have also been unestablished. | 2014 | 24289889 |
| assessment of the loop-mediated isothermal amplification assay for rapid diagnosis of mycoplasma pneumoniae in pediatric community-acquired pneumonia. | rapid diagnosis of mycoplasma pneumoniae pneumonia is required for timely treatment with effective antibiotics; however, pcr-based methods are often too expensive and technologically intensive for general use in clinical practice. in this study, the efficacy of the loop-mediated isothermal amplification (lamp) assay for diagnosis of m. pneumoniae pneumonia in clinical practice was prospectively evaluated. from july 2011 to march 2012, 531 children hospitalized for community-acquired pneumonia we ... | 2013 | 24270147 |
| detection of mycoplasma pneumoniae p1 subtype variations by denaturing gradient gel electrophoresis. | there were several methods to detect p1 gene variations in mycoplasma pneumoniae. in this study polymerase chain reaction (pcr)-based denaturing gradient gel electrophoresis (dgge) assay was performed to establish a rapid and precise detection method for identifying m. pneumoniae p1 gene variations. we detected p1 gene variations in 109m. pneumoniae clinical isolates from shanghai, china, which were collected from 2009 to 2011 by dgge, and compared this method with the pcr-based restriction frag ... | 2014 | 24268834 |
| [acute respiratory failure due to mycoplasma pneumonia]. | respiratory infections due to mycoplasma pneumoniae are typically mild and subacute. we report the case of a 40-year-old man hospitalized for acute respiratory distress in the context of an acute infection with mycoplasma pneumoniae. radiological and pulmonary function test were consistent with an acute infectious bronchiolitis. | 2013 | 24267769 |
| [mycoplasma pneumoniae respiratory infections in adults: beware atypical cases!]. | | 2013 | 24267763 |
| [progress in studies on mycoplasma pneumoniae-produced community-acquired respiratory distress syndrome toxin]. | | 2013 | 24267145 |
| [arterial thrombosis induced by mycoplasma pneumoniae infection: report of two cases]. | | 2013 | 24267140 |
| erythema bullous multiforme: a complication of mycoplasma pneumoniae infection. | | 2014 | 24252790 |
| surveillance of drug-resistance in mycoplasma pneumoniae and analysis of clinical features of mycoplasma pneumoniae pneumonia in childhood. | | 2013 | 24238525 |
| mycoplasma pneumoniae infection is associated with subacute cough. | | 2014 | 24232705 |
| [comparison of clinical features and co-infection between pneumonia caused by influenza virus a and pneumonia caused by influenza virus b among children]. | to compare the clinical features and co-infection between pneumonia caused by influenza virus a (iva) and pneumonia caused by influenza virus b (ivb) among children. | 2013 | 24229596 |
| clinical utility of loop-mediated isothermal amplification for rapid diagnosis of mycoplasma pneumoniae in children. | loop-mediated isothermal amplification (lamp) is a cost-effective and rapid method for identifying mycoplasma pneumoniae (mp). we investigated the utility of the lamp assay in diagnosing mp pneumonia among children in a clinical setting. in this prospective study, the cause of community-acquired pneumonia was evaluated in 111 patients for whom mp was the suspected pathogen. all participants were patients at a city hospital in japan between april 2012 and september 2012. throat swabs for the lamp ... | 2014 | 24227877 |
| precursor-directed biosynthesis of micacocidin derivatives with activity against mycoplasma pneumoniae. | micacocidin is a promising natural product for the treatment of mycoplasma pneumoniae infections. in the biosynthesis of this antibiotic, a fatty acid-amp ligase (faal) activates the starter unit hexanoic acid as acyl-adenylate and forwards it to an iteratively acting polyketide synthase. biochemical analysis of the faal revealed an extended substrate tolerance, thereby opening the door for the modification of a micacocidin residue that is barely accessible via semisynthesis. a total of six new ... | 2014 | 24202877 |
| [fever, skin rash and blood bullae of the ears in a middle-aged woman]. | a healthcare worker sought medical advice after four days of fever, muscle pains, occipital headache and blocked ears, and was diagnosed with a high crp level and blood bullae in the outer ear canal. in addition, skin rash appeared during hospital care, and the fever did not seem to go down upon treatment with broad-spectrum antibiotics, during which the crp rose to a level of 413 mg/l at the highest. haemorragic bullous otisis was confirmed diagnosis caused by mycoplasma pneumoniae. | 2013 | 24187785 |
| [etiologic characteristics of adult patients with community-acquired pneumonia in beijing]. | to explore the etiologic characteristics of adult patients with community-acquired pneumonia (cap) in beijing. | 2013 | 24169282 |
| comparative effectiveness of ceftriaxone in combination with a macrolide compared with ceftriaxone alone for pediatric patients hospitalized with community-acquired pneumonia. | guidelines for management of community-acquired pneumonia recommend empiric therapy with a macrolide and beta-lactam when infection with mycoplasma pneumoniae is a significant consideration. evidence to support this recommendation is limited. we sought to determine the effectiveness of ceftriaxone alone compared with ceftriaxone combined with a macrolide with respect to length of stay and total hospital costs. | 2014 | 24168982 |
| p1 gene of mycoplasma pneumoniae in clinical isolates collected in beijing in 2010 and relationship between genotyping and macrolide resistance. | mycoplasma pneumoniae is a common pathogen that caused community-acquired pneumonia (cap). p1 protein served as major adhesion and immunodominant protein in mycoplasma pneumoniae, but little about p1 gene was learned and the relationship between p1 genotype and macrolide resistance has yet to be explored. | 2013 | 24157163 |
| cerebellitis and acute obstructive hydrocephalus associated with mycoplasma pneumoniae infection. | mycoplasma pneumoniae is associated with a variety of extrapulmonary manifestations, including central nervous system inflammation. a 9-year-old boy presented with acute cerebellitis and m. pneumoniae infection, resulting in obstructive hydrocephalus requiring neurosurgical intervention. this case, along with 4 similar ones reported in the literature, suggests a distinct clinicopathologic sequence caused by mycoplasma infection. | 2014 | 24153008 |
| soluble b7-h3 elevations in hospitalized children with mycoplasma pneumoniae pneumonia. | the purpose of this study is to explore the associations between soluble b7-h3 (sb7-h3) and cytokines, clinical characteristics and laboratory findings. thirty-two children with mycoplasma pneumoniae pneumonia diagnosed by both positive serology and pcr were admitted to children's hospital affiliated to soochow university. these children were enrolled and evaluated from may 2012 through september 2012. soluble b7-h3 level and cytokines (tumor necrosis factor-α (tnf-α), interferon-γ, interleukin ... | 2013 | 24139879 |
| [mycoplasma pneumoniae encephalitis successfully treated by levofloxacin]. | mycoplasma pneumonia (mp) infection may be associated with several neurological complications. encephalitis, which affects children and rarely young adults, is the most frequent. | 2015 | 24135061 |
| [effect of low-dose methylprednisolone on serum tnf-α level in children with mycoplasma pneumoniae pneumonia]. | to investigate the effect of low-dose methylprednisolone on serum tumor necrosis factor alpha (tnf-α) level in children with mycoplasma pneumoniae pneumonia (mpp). | 2013 | 24131837 |
| [mycoplasma-pneumoniae-associated mucositis]. | the pathogen mycoplasma pneumonia is a frequent cause of respiratory tract infections, especially in adolescents. less well known is that this infection may also be associated with extrapulmonary manifestations including m. pneumonia associated mucositis (mpam). | 2013 | 24128598 |
| unilateral widespread lichen planus following blaschko's lines after mycoplasma pneumoniae infection. | | 2013 | 24111945 |
| association of mycoplasma pneumoniae infection with henoch-schonlein purpura. | we present a child with henoch-schonlein purpura and mycoplasma pneumoniae infection, an association that was rarely described in the literature. the infection was confirmed serologically and by using pcr. | 2013 | 24093818 |
| sensory polymyeloradiculopathy associated with toscana virus infection. | sandfly viruses are arthropod-borne viruses that are endemic in the mediterranean basin. the toscana virus (tosv) is the only serotype of sandfly viruses known to cause neurological symptoms in humans, usually aseptic meningitis or meningoencephalitis. we report a case of a 39-year-old man who was admitted to our department with progressive paresthesias of the lower limbs followed by dysesthesias of the upper thorax after a hiking trip to the netherlands. the patient had also been suffering from ... | 2013 | 24081884 |
| two separated thrombi in deep veins associated with pulmonary embolism after mycoplasma pneumoniae infection: a case in adolescent female. | mycoplasma pneumoniae is a common pathogen for respiratory infection in children, and vascular complication is one of the rarest extrapulmonary complications but with serious consequences. we report a twelve-year-old chinese female presenting with fever, dry cough, and chest pain aggravated by respiration. she was diagnosed pneumonia due to mycoplasma pneumoniae and treated with azithromycin until unexpected tachypnea and swelling in the right lower limb happened. then ultrasonic examination had ... | 2013 | 26835314 |
| molecular detection of mycoplasma pneumoniae by quantitative real-time pcr in patients with community acquired pneumonia. | mycoplasma pneumoniae is the most important and common cause of community-acquired pneumonia (cap). the conventional detection methods (culture and serology) lack sensitivity. pcr offers a better approach for rapid detection but is prone to carry over contamination during manipulation of amplification products. quantitative real-time pcr (qrt-pcr) method offers an attractive alternative detection method. in the present study, qrt-pcr, pcr and serology methods were used to detect m. pneumoniae in ... | 2013 | 24056602 |
| real-time pcr detection of mycoplasma pneumoniae in respiratory specimens. | a real-time pcr assay targeting the phosphotransferase system i gene (ptsi) of mycoplasma pneumoniae was compared to 2 commercially available pcr assays targeting the p1 cytadhesion gene (the lightmix®kit mycoplasma pneumoniae [tib molbiol, adelphia, nj, usa] and m. pneumoniae analyte specific reagent [focus diagnostics, cypress, ca, usa] assays) and to a pcr assay targeting the m. pneumoniae repetitive element, repmp1. thirty previously positive specimens including 15 throat swab, 10 bronchoalv ... | 2013 | 24041553 |
| age-specific mycoplasma pneumoniae pneumonia-associated myocardial damage in children. | to measure mycoplasma pneumoniae pneumonia (mpp)-associated myocardial damage in different age groups of children with pneumonia. | 2013 | 24026772 |
| mycoplasma pneumoniae-induced recurrent stevens-johnson syndrome in children: a case report. | mycoplasma pneumoniae, the major pathogen of primary atypical pneumonia, is reported as the most common infectious agent associated with stevens-johnson syndrome (sjs) in children. for that reason it is important to consider mycoplasma infection also in the absence of classical pulmonary symptoms. sjs is a rare and acute, self-limited disease, characterized by severe inflammation and necrosis of two or more mucous membranes. we report the case of a 12-year-old boy with a diagnosis of sjs induced ... | 2013 | 24016288 |
| clinical outcomes and macrolide resistance in mycoplasma pneumoniae infection in scotland, uk. | mycoplasma pneumoniae has a cyclical, epidemic pattern of infection and the most recent epidemic occurred in europe in 2011. macrolides are recommended for the treatment of m. pneumoniae respiratory tract infection, but macrolide resistance has been reported at low levels in europe. the aim of the study was to examine the clinical impact of the recent m. pneumoniae epidemic in a hospital setting in scotland and to determine whether macrolide-resistant strains are present. data were analysed retr ... | 2013 | 24008501 |
| toxic epidermal necrolysis from suspected mycoplasma pneumoniae infection. | toxic epidermal necrolysis (ten) is primarily associated with medication use. presented is a patient with likely mycoplasma pneumoniae infection and progression to ten. | 2013 | 24005558 |
| [microflora of palatine tonsils in chronic tonsillitis]. | the objective of the present work was to develop the standardized approaches to pharmacotherapy of chronic tonsillitis based on the data of regional specificity of the tonsillar microflora. the methods of investigations included the study of throat swabs obtained from 668 patients presenting with various forms of chronic tonsillitis (ct). half of these patients were shown to be infected with streptococcus pyogenes and 24.5% with mycoplasma pneumoniae. the presence of concomitant pathology of the ... | 2013 | 24005268 |
| hemophagocytic syndrome associated with mycoplasma pneumoniae pneumonia. | mycoplasma pneumoniae (mp) sometimes causes immunological complications in children. we present a rare case of hemophagocytic syndrome (hps) caused by mp in a previously healthy 7-year-old japanese girl. a chest radiograph obtained to evaluate the source of her fever showed infiltration in the lower right lung with mild splenomegaly. we could diagnose the patient with hps on the basis of the hemophagocytic-lymphohistiocytosis- (hlh) 2004 criteria. she met the criteria for fever, splenomegaly, ne ... | 2013 | 23970989 |
| macrolide-resistant mycoplasma pneumoniae in humans, ontario, canada, 2010-2011. | antimicrobial drug resistance rates for mycoplasma pneumoniae was determined in clinical specimens and isolates obtained during 2011-2012 in ontario, canada. of 91 m. pneumoniae drug-resistant specimens, 11 (12.1%) carried nucleotide mutations associated with macrolide resistance in the 23s rrna gene. none of the m. pneumoniae specimens were resistant to fluoroquinolones or tetracyclines. | 2013 | 23968896 |
| prognostic values of a combination of intervals between respiratory illness and onset of neurological symptoms and elevated serum igm titers in mycoplasma pneumoniae encephalopathy. | to retrospectively analyze the clinical manifestations of mycoplasma pneumoniae (m. pneumoniae)-associated encephalopathy in pediatric patients. | 2014 | 23968755 |
| cluster of macrolide-resistant mycoplasma pneumoniae infections in illinois in 2012. | macrolide-resistant mycoplasma pneumoniae is an increasing problem worldwide but is not well documented in the united states. we report a cluster of macrolide-resistant m. pneumoniae cases among a mother and two daughters. | 2013 | 23966493 |
| [changes in plasma levels of thrombomodulin and d-dimer in children with different types of mycoplasma pneumoniae pneumonia]. | to investigate the changes in plasma levels of thrombomodulin (tm) and d-dimer (dd) in children with different types of mycoplasma pneumoniae pneumonia (mpp), and their role in the pathogenesis of mpp in children. | 2013 | 23965872 |
| [unusual presentation of a severe mycoplasma pneumoniae infection: report of 2 cases]. | mycoplasma pneumonia is responsible for multisystemic infection. pulmonary symptoms are most common in children. we describe herein two unusual severe forms of m. pneumoniae infection without initial pulmonary symptoms. the first case is an 8-month-old boy who was hospitalized in the pediatric intensive care unit with severe sepsis. there were no initial pulmonary symptoms, nor obvious clinical infection. initial blood tests and x-ray did not aid the diagnosis. the blood tests came back positive ... | 2013 | 23953627 |
| development of protective anti-mycoplasma pneumoniae antibodies after immunization of guinea pigs with the combination of a p1-p30 chimeric recombinant protein and chitosan. | the attachment organelle of the human respiratory tract pathogen mycoplasma pneumoniae is essential for colonization of the host mucosa. furthermore, adherence-related proteins such as the major adhesin p1 and protein p30 represent vaccine candidates. using the chimeric recombinant protein hp14/30, which combines surface-localized and adherence-involved regions of both proteins, we developed an optimized strategy to immunize guinea pigs. the vaccination protocol includes subcutaneous prime immun ... | 2013 | 23948467 |
| epidemiology of community-acquired mycoplasma pneumoniae respiratory tract infections among hospitalized chinese children, including relationships with meteorological factors. | mycoplasma pneumoniae (m. pneumoniae) is a common cause of respiratory tract infections (rtis), especially in children. combined diagnostic techniques have provided more reliable information about the epidemiology of infections by this pathogen. the relationship between m. pneumoniae rtis and climatic conditions is not well documented in the literature. | 2013 | 23935339 |
| [pulmonary necrotizing cavity caused by mycoplasma pneumoniae infection]. | | 2013 | 23932661 |
| impact of bacterial and viral coinfection on mycoplasmal pneumonia in childhood community-acquired pneumonia. | coinfection of mycoplasma pneumoniae is not uncommon in children with respiratory syndromes. the purpose of this study was to investigate the impact of bacterial and viral coinfection on mycoplasmal pneumonia in hospitalized children with community-acquired pneumonia (cap). | 2015 | 23927825 |
| inhibition of mycoplasma pneumoniae growth by fda-approved anticancer and antiviral nucleoside and nucleobase analogs. | mycoplasma pneumoniae (mpn) is a human pathogen that causes acute and chronic respiratory diseases and has been linked to many extrapulmonary diseases. due to the lack of cell wall, mpn is resistant to antibiotics targeting cell wall synthesis such as penicillin. during the last 10 years macrolide-resistant mpn strains have been frequently reported in asian countries and have been spreading to europe and the united states. therefore, new antibiotics are needed. in this study, 30 fda-approved ant ... | 2013 | 23919755 |
| mycoplasma pneumoniae outbreak at a university - georgia, 2012. | on october 17, 2012, the georgia department of public health (dph) was notified by the fulton county department of health and wellness that a local university, the georgia institute of technology, was experiencing a pneumonia outbreak among students. dph epidemiologists investigated to identify the etiology, find additional cases, and recommend control measures. respiratory swabs collected from students with pneumonia and tested at cdc using a quantitative real-time polymerase chain reaction (qp ... | 2013 | 23903594 |
| macrolide-resistant mycoplasma pneumoniae pneumonia in adolescents and adults: clinical findings, drug susceptibility, and therapeutic efficacy. | we investigated differences in the clinical findings between 30 patients with macrolide-resistant mycoplasma pneumoniae pneumonia and 43 patients with macrolide-sensitive m. pneumoniae pneumonia in adolescents and adults. no differences in clinical presentation were observed between the two groups. among patients with macrolide-resistant mycoplasma pneumoniae pneumonia, treatment was more effective in the groups that received quinolones and minocycline than in the group that received macrolides ... | 2013 | 23896480 |
| macrolide resistance of mycoplasma pneumoniae, south korea, 2000-2011. | in korea, mycoplasma pneumoniae was detected in 255/2,089 respiratory specimens collected during 2000-2011; 80 isolates carried 23s rrna gene mutations, and 69/123 culture-positive samples with the mutation were resistant to 5 macrolides. during 2000-2011, prevalence of the mutation increased substantially. these findings have critical implications for the treatment of children with mycoplasma pneumonia. | 2013 | 23876792 |
| [mycoplasma pneumoniae infection and drug resistance in children: an analysis of 1026 cases]. | to investigate the mycoplasma pneumoniae (mp) infection and drug resistance in children with respiratory tract infection and to provide a rational basis for the clinical diagnosis and treatment of mp infection. | 2013 | 23866271 |
| characterization of macrolide resistance of mycoplasma pneumoniae in children in shenzhen, china. | macrolide-resistant mycoplasma pneumoniae (mr-m. pneumoniae) was isolated from clinical specimens in shenzhen, china from november 2010 to july 2011. a comparative study was conducted to determine whether macrolides are effective in treating patients infected with mr-m. pneumoniae. of 57 m. pneumoniae strains, 36 harbored point mutations on a2063g in the 23s ribosomal rna gene. a total of 36 (63%) strains were classified as mr-m. pneumonia and 21 (37%) as macrolide-susceptible m. pneumoniae (ms- ... | 2014 | 23861188 |
| diagnosis of herpes simplex virus-induced erythema multiforme confounded by previous infection with mycoplasma pneumonia. | erythema multiforme (em) is an immune-mediated hypersensitivity reaction often related to viral infection or medications. infection-induced em is typically self-limited and commonly caused by herpes simplex virus (hsv) or mycoplasma pneumoniae (mp); recurrent em is almost always associated with hsv. we present a concise overview of diagnostic techniques for hsv and mp, as repeatedly elevated mp titers in our case led to a delayed diagnosis of hsv-induced em. | 2013 | 23839193 |
| [case of tuberculous pleurisy distinguished from pleurisy caused by mycoplasma infection]. | we report a case of tuberculous pleurisy that required differentiation from pleurisy caused by mycoplasma infection. a 28-year-old woman presented to a clinic with fever and pain on the left side of her chest. a chest radiograph revealed pleural effusion in the left thorax, and the condition was diagnosed as bacterial pleurisy. the patient was referred to our hospital because of an increase in the pleural effusion despite antibiotic treatment. mycoplasma infection was suspected because the patie ... | 2013 | 23819319 |
| rapid defervescence after doxycycline treatment of macrolide-resistant mycoplasma pneumoniae-associated community-acquired pneumonia in children. | we did a retrospective review of children with mycoplasma pneumoniae infection hospitalized from march 2010 to march 2013. mycoplasma-resistant m. pneumoniae constituted 70% of the total m. pneumoniae-associated community-acquired pneumonia. doxycycline was significantly more effective than macrolide for treatment of mycoplasma-resistant m. pneumoniae-associated community-acquired pneumonia in terms of achievement of rapid defervescence within 24 hours. | 2013 | 23817339 |
| hemolytic uremic syndrome complicating mycoplasma pneumoniae infection. | mycoplasma pneumoniae can cause various extrapulmonary manifestations but, to our knowledge, no case of mycoplasma pneumoniae associated with hemolytic uremic syndrome (hus) has been reported. | 2013 | 23800801 |
| mycoplasma pneumoniae intrathecal antibody responses in bickerstaff brain stem encephalitis. | the pathogenesis of mycoplasma pneumoniae encephalitis is not established. we report, for the first time, the case of a patient with severe bickerstaff brain stem encephalitis in whom we detected intrathecal production of m. pneumoniae-specific antibodies, contrasting the findings in another patient with less severe encephalitis in whom we detected intrathecal m. pneumoniae dna but no specific antibodies. our observations suggest that intrathecal m. pneumoniae-specific antibody responses may con ... | 2014 | 23794446 |
| modulation of il-8 boosted by mycoplasma pneumoniae lysate in human airway epithelial cells. | mycoplasma pneumoniae, a major cause of community-acquired pneumonia, has been recognized as a trigger for asthma inception and exacerbation. the epithelial cells on the respiratory tract parasitized by m. pneumoniae exhibit a number of cytopathic effects as a result of local inflammation and stimulated host immune response. we investigated the interactions of signaling molecules regulating the release of il-8 by the direct stimulation of m. pneumoniae lysate (mpl) in human airway epithelial cel ... | 2013 | 23779254 |
| coexistence of myositis, transverse myelitis, and guillain barré syndrome following mycoplasma pneumoniae infection in an adolescent. | guillain-barré syndrome (gbs) and transverse myelitis may occur coexistently in the pediatric population. this may be explained by a shared epitope between peripheral and central nervous system myelin. coexistent transverse myelitis, myositis, and acute motor neuropathy in childhood have not been previously described. we describe a 14-year-old female patient with transverse myelitis, myositis, and gbs following mycoplasma pneumoniae infection. she presented with weakness and walking disability. ... | 2013 | 23772249 |
| successful use of saliva without dna extraction for detection of macrolide-resistant mycoplasma pneumoniae dna in children using lna probe-based real-time pcr. | it is not known that saliva is useful to diagnose mycoplasma pneumoniae (m. pneumoniae) infection by pcr. we evaluated prospectively whether crude saliva samples without the dna extraction process were useful for the detection of m. pneumoniae dna in a locked nucleic acid (lna) probe-based real-time pcr assay. fifty-one clinical specimens (29 sputum, 22 saliva) that were positive by conventional m. pneumoniae-specific pcr were evaluated in this study. we designed an lna probe-based real-time pcr ... | 2013 | 23771735 |
| [chest ct features and outcome of necrotizing pneumonia caused by mycoplasma pneumoniae in children (report of 30 cases)]. | to summarize the chest ct features and outcome of necrotizing pneumonia (np) caused by mycoplasma pneumoniae in children and to review the changes of common inflammatory parameters in np patients to help clinicians understand the proper timing of ct scan. | 2013 | 23751584 |
| [protective immune responses induced by intranasal immunization with mycoplasma pneumoniae p1c-il-2 fusion dna vaccine in mice]. | to investigate the immune responses and immune protections of a dna vaccine constructed by fusing mycoplasma pneumoniae (m. pneumoniae) p1 gene car boxy terminal region (p1c gene) with interleukin-2 (il-2) gene. | 2013 | 23746241 |
| multiple-locus variable-number tandem-repeat analysis of mycoplasma pneumoniae clinical specimens and proposal for amendment of mlva nomenclature. | mycoplasma pneumoniae is one of the major respiratory bacterial pathogens that cause pneumonia in humans. multiple-locus variable-number tandem-repeat analysis (mlva) is currently the most discriminative method for typing m. pneumoniae strains. to better understand the epidemic of m. pneumoniae-related pneumonia in pediatric patients in beijing, china, we performed mlva analysis on 118 specimens collected during an epidemic from 2010-2012. eleven distinct mlva types were identified, including fo ... | 2013 | 23737989 |
| comparison of real-time polymerase chain reaction and serological tests for the confirmation of mycoplasma pneumoniae infection in children with clinical diagnosis of atypical pneumonia. | mycoplasma pneumoniae is a common pathogen of respiratory tract infection in children, and its correct and rapid diagnosis is a clinical challenge. real-time polymerase chain reaction (rt-pcr) has been used frequently for the detection of this pathogen. | 2014 | 23726653 |
| comparison of pyrosequencing, sanger sequencing, and melting curve analysis for detection of low-frequency macrolide-resistant mycoplasma pneumoniae quasispecies in respiratory specimens. | macrolide-resistant mycoplasma pneumoniae (mrmp) is emerging worldwide and has been associated with treatment failure. in this study, we used pyrosequencing to detect low-frequency mrmp quasispecies in respiratory specimens, and we compared the findings with those obtained by sanger sequencing and simpleprobe pcr coupled with a melting curve analysis (simpleprobe pcr). sanger sequencing, simpleprobe pcr, and pyrosequencing were successfully performed for 96.7% (88/91), 96.7% (88/91), and 93.4% ( ... | 2013 | 23720793 |
| nationwide surveillance of macrolide-resistant mycoplasma pneumoniae infection in pediatric patients. | we conducted nationwide surveillance to investigate regional differences in macrolide-resistant (mr) mycoplasma pneumoniae strains in japan. the prevalence of mr m. pneumoniae in pediatric patients gradually increased between 2008 and 2012. although regional differences were observed, high levels of mr genes were detected in all seven surveillance areas throughout japan and ranged in prevalence from 50% to 93%. these regional differences were closely related to the previous administration of mac ... | 2013 | 23716043 |
| mycoplasma pneumoniae infection or harmless colonisation? | | 2013 | 23697874 |
| aortic thrombus and multiple embolisms during a mycoplasma pneumoniae infection. | we report the case of a patient who presented with a thrombus of the aortic arch complicated with splenic, renal and peroneal artery embolisms, associated with transient lupus anticoagulant, during a mycoplasma pneumoniae infection. the outcome was good under antibiotic and anticoagulant treatment. we also review the medical literature on m. pneumoniae-related thromboses. | 2013 | 23696110 |
| epidemiology of ophthalmologic disease associated with erythema multiforme, stevens-johnson syndrome, and toxic epidermal necrolysis in hospitalized children in the united states. | the objective of the current study was to characterize the epidemiology and resource use of u.s. children hospitalized with ophthalmologic disease secondary to erythema multiforme (em), stevens-johnson syndrome (sjs), and toxic epidermal necrolysis (ten). we studied children ages 5 to 19 years hospitalized in 2005 in 11 states, encompassing 38% of the u.s. pediatric population. using international classification of diseases, ninth revision, clinical modification codes, we identified admissions o ... | 2016 | 23679157 |
| clinical characteristics of children with mycoplasma pneumoniae infection hospitalized during the danish 2010-2012 epidemic. | mycoplasma pneumoniae is a common cause of community-acquired pneumonia. pneumonia may be the most severe manifestation of respiratory m. pneumoniae infection. the most typical symptoms in children are cough and wheezing, which are often accompanied by upper respiratory tract manifestations mimicking viralrespiratory syndromes. | 2013 | 23673264 |
| mycoplasma pneumoniae cards toxin is internalized via clathrin-mediated endocytosis. | bacterial toxins possess specific mechanisms of binding and uptake by mammalian cells. mycoplasma pneumoniae cards (community acquired respiratory distress syndrome) toxin is a 68 kda protein, which demonstrates high binding affinity to human surfactant protein-a and exhibits specific biological activities including mono-adp ribosylation and vacuolization. these properties lead to inflammatory processes in the airway and a range of cytopathologies including ciliostasis, loss of tissue integrity ... | 2013 | 23667510 |