| a 14-year-old boy with mycoplasma pneumoniae-associated mucositis and intracranial hypertension. | | 2016 | 25667310 |
| pericardial mass and cardiac tamponade associated with mycoplasma pneumoniae. | | 2015 | 25650218 |
| the inhibition of platycodin d on mycoplasma pneumoniae proliferation and its effect on promoting cell growth after anti-mycoplasma pneumoniae treatment. | platycodin d, extract from the root of platycodon grandiflorum, is one of the most important monomers of the qinbaiqingfei pellets (qinbai) that has already been approved as the first traditional chinese medicine for clinic use as an anti-m. pneumoniae agent. qinbai constituents scutellaria baicalensis and platycodon grandiflorum were used to treat thousands of patients clinically in china each year. in this study, a m. pneumoniae-infected mouse strain, balb/c, and a human-derived epithelial cel ... | 2014 | 25629010 |
| defining a minimal cell: essentiality of small orfs and ncrnas in a genome-reduced bacterium. | identifying all essential genomic components is critical for the assembly of minimal artificial life. in the genome-reduced bacterium mycoplasma pneumoniae, we found that small orfs (smorfs; < 100 residues), accounting for 10% of all orfs, are the most frequently essential genomic components (53%), followed by conventional orfs (49%). essentiality of smorfs may be explained by their function as members of protein and/or dna/rna complexes. in larger proteins, essentiality applied to individual do ... | 2015 | 25609650 |
| [hemolysis, serositis and exanthema induced by mycoplasma pneumoniae infection. report of one case]. | mycoplasma infections have extrapulmonary manifestations that may be associated with respiratory symptoms and may have skin, heart, gastrointestinal, rheumatologic, neurologic, hematologic involvement. cold agglutinin mediated autoimmune hemolytic anemia is the most common hematological manifestation. we report a 27-year-old woman infected with mycoplasma pneumoniae, who presented respiratory involvement with pneumonia, exanthema, serositis and acute hemolytic anemia that required transfusion. t ... | 2014 | 25601120 |
| bronchiolitis associated with mycoplasma pneumoniae in infants in suzhou china between 2010 and 2012. | viruses cause most cases of bronchiolitis in infants; consequently the importance of other agents such as mycoplasma pneumoniae (mp) in the etiology of bronchiolitis may not be fully recognized. we investigated the prevalence and seasonal distribution of bronchiolitis caused by mp in 674 children admitted to the children's hospital affiliated with soochow university from january 2010 to december 2012. the presence of mp was confirmed by real-time pcr. during the 3 years, we identified mp in 17.2 ... | 2015 | 25597274 |
| differentiation between mycoplasma and viral community-acquired pneumonia in children with lobe or multi foci infiltration: a retrospective case study. | to analyse the clinical features, inflammatory markers and radiographs of community-acquired pneumonia (cap) cases with lobe or multi foci infiltration; with a special focus on factors which allow the differential diagnosis of viral and mycoplasma pneumonia. | 2015 | 25596200 |
| mycoplasma pneumoniae-induced rash and mucositis as a syndrome distinct from stevens-johnson syndrome and erythema multiforme: a systematic review. | mycoplasma pneumoniae infection is associated with extrapulmonary complications, including mucocutaneous eruptions. these eruptions, which have been termed either "stevens-johnson syndrome" or "erythema multiforme" in the literature, may differ from drug-induced stevens-johnson syndrome or viral-associated erythema multiforme. | 2015 | 25592340 |
| fuchs' syndrome (stevens-johnson syndrome without skin involvement) in an adult male--a case report and general characteristics of the sporadically diagnosed disease. | fuchs' syndrome (stevens-johnson syndrome without skin involvement) is a sporadically diagnosed disease. most authors consider it to be a pure mucosal variant of stevens-johnson syndrome; however, some consider the syndrome a separate entity. the complete absence of cutaneous symptoms may be the reason that not all cases of fuchs' syndrome are diagnosed and properly classified. the authors describe a case of a 22-year-old patient suffering only from mucosal symptoms, diagnosed as fuchs' syndrome ... | 2014 | 25580788 |
| bilateral optic neuritis following mycoplasma pneumoniae infection. | | 2014 | 25579368 |
| antibiotics for community-acquired lower respiratory tract infections secondary to mycoplasma pneumoniae in children. | background. mycoplasma pneumoniae (m. pneumoniae) is widely recognised as an important cause of community-acquired lower respiratory tract infection (lrti) in children. pulmonary manifestations are typically tracheobronchitis or pneumonia but m. pneumoniae is also implicated in wheezing episodes in both asthmatic and non-asthmatic individuals. although antibiotics are used to treat lrtis, are view of several major textbooks offers conflicting advice for using antibiotics in the management of m. ... | 2015 | 25566754 |
| early additional immune-modulators for mycoplasma pneumoniae pneumonia in children: an observation study. | mycoplasma pneumoniae (mp) pneumonia is a self-limiting disease, but some patients complain of progressive pneumonia, despite of appropriate antibiotic treatment. we aimed to introduce the role of immune-modulators (corticosteroid and/or intravenous immunoglobulin, ivig) treatment for childhood mp pneumonia based on previous our experiences. | 2014 | 25566403 |
| severe macrolide-resistant mycoplasma pneumoniae pneumonia associated with macrolide failure. | we investigated differences in outcomes between 68 children hospitalized with macrolide-sensitive mycoplasma pneumoniae pneumonia (msmp group) and 25 children hospitalized with macrolide-resistant m. pneumoniae pneumonia (mrmp group). in the mrmp group, 19 children received macrolides and clinical failure occurred in six of which five had pneumonia progression during therapy. | 2016 | 25556047 |
| [analysis of 3 cases with mycoplasma pneumoniae-associated hemophagocytic syndrome and review of literature]. | to analyze the clinical characteristics of mycoplasma pneumoniae-associated hemophagocytic syndrome (mp-hlh). | 2014 | 25537549 |
| setting a standard for the initiation of steroid therapy in refractory or severe mycoplasma pneumoniae pneumonia in adolescents and adults. | serum interleukin (il)-18 level was thought to be a useful as a predictor of refractory or severe mycoplasma pneumoniae pneumonia, and steroid administration is reported to be effective in this situation. the serum levels of il-18 correlated significantly with those of lactate dehydrogenase (ldh). the purpose of this study was to set a standard for the initiation of steroid therapy in m. pneumoniae pneumonia using a simple serum marker. we analyzed 41 adolescent and adult patients with refractor ... | 2015 | 25533771 |
| mycoplasma pneumoniae as a causative agent of community-acquired pneumonia in children: clinical features and laboratory diagnosis. | mycoplasma pneumoniae is a common cause of community-acquired pneumonia (cap) in children. the aim of this study was to assess the prevalence of mycoplasma pneumoniae infection in children with cap and find clinical, radiological and laboratory features helpful to diagnose mycoplasma pneumoniae pneumonia. furthermore, we evaluated the value of serology, real-time pcr (rt-pcr) and culture for the accurate diagnosis of mycoplasma pneumoniae pneumonia. | 2014 | 25518734 |
| detection, characterization, and molecular typing of human mycoplasma spp. from major hospitals in cairo, egypt. | mycoplasmas are fastidious slow growing organisms lacking a cell wall and mostly isolated from the mucosal surfaces of the respiratory and genitourinary tracts. there is a dearth of information regarding clinical mycoplasma spp. isolates among egyptian patients. a total of 170 samples were collected from patients and apparently healthy personnel in local public hospitals in cairo, egypt. isolation of mycoplasma spp. was carried out using appropriate culture media and further identification was c ... | 2014 | 25506614 |
| a 15-year review of pediatric toxic epidermal necrolysis. | owing to the rare, yet serious nature of toxic epidermal necrolysis (ten) and stevens-johnson syndrome (sjs), the authors would like to describe our experience with 41 pediatric patients to contribute to the current clinical understanding of the disease. from records at a single institution, 41 patients ≤18 years of age with a diagnosis of sjs or ten were retrospectively identified. data were obtained from the hospital's medical record, and a variety of variables were collected, including causat ... | 2015 | 25501779 |
| fm to am nucleic acid amplification for molecular diagnostics in a non-stick-coated metal microfluidic bioreactor. | a sensitive dna isothermal amplification method for the detection of dna at fm to am concentrations for pathogen identification was developed using a non-stick-coated metal microfluidic bioreactor. a portable confocal optical detector was utilized to monitor the dna amplification in micro- to nanoliter reaction assays in real-time, with fluorescence collection near the optical diffraction limit. the non-stick-coated metal microfluidic bioreactor, with a surface contact angle of 103°, was largely ... | 2014 | 25475544 |
| macrolide-resistant mycoplasma pneumoniae in adults in zhejiang, china. | mycoplasma pneumoniae is a major pathogen causing community-acquired pneumoniae (cap), which is generally treated with macrolides. in recent years, however, although macrolide-resistant m. pneumoniae has been reported frequently, particularly in china, very little is known about the prevalence of macrolide-resistant m. pneumoniae infection in adults. in this study, we survey the macrolide-resistant m. pneumoniae in adults in zhejiang province and characterize the mechanisms of resistance to macr ... | 2015 | 25451048 |
| molecular characterization of macrolide resistance of a mycoplasma pneumoniae strain that developed during therapy of a patient with pneumonia. | the development of macrolide resistance that occurred during 3 days of therapy with azithromycin to treat mycoplasma pneumoniae pneumonia in a paediatric patient is reported. after extended molecular characterization of strains, the parallel occurrence of clones showing the non-mutated wild-type 23s rrna sequence as well as mutations a2063g and a2064g, which are both responsible for phenotypic resistance, was confirmed for the first time. | 2014 | 25449256 |
| clinical and laboratory profiles of refractory mycoplasma pneumoniae pneumonia in children. | the purpose of this study was to explore the clinical and laboratory characteristics of children with refractory mycoplasma pneumoniae pneumonia (rmpp). | 2014 | 25449230 |
| mycoplasma pneumonia--associated mucocutaneous disease in children: dilemmas in classification. | there is controversy regarding precise definitions for stevens-johnson syndrome (sjs) and erythema multiforme (em) major because of overlap in clinical presentations. sjs and em major associated with mycoplasma pneumoniae have been reported to occur in children, but mycoplasma is more commonly reported with sjs. we sought to further characterize mycoplasma-associated mucocutaneous disease. through retrospective chart review over 10 years, six children hospitalized with a diagnosis of sjs who als ... | 2014 | 25424207 |
| mycoplasma-associated stevens-johnson syndrome in children: retrospective review of patients managed with or without intravenous immunoglobulin, systemic corticosteroids, or a combination of therapies. | administration of intravenous immunoglobulin (ivig) to patients with stevens-johnson syndrome (sjs) has been controversial. the objective of this study was to evaluate the effectiveness of ivig, systemic corticosteroids, or both in treating mycoplasma pneumoniae-associated sjs (mpsjs). retrospective series of 10 pediatric mpsjs cases were stratified into four treatment groups: ivig alone, ivig and systemic corticosteroids together, systemic corticosteroids alone, and supportive care. the efficac ... | 2014 | 25424206 |
| [an outbreak of respiratory tract infections in an institution: combating mycoplasma pneumoniae in mentally disabled persons]. | in october 2013, the municipal health service, rotterdam, the netherlands, was notified of an outbreak of mycoplasma pneumoniae infections in an institution for mentally disabled persons. | 2014 | 25406814 |
| drug induced erythema multiforme: two case series with review of literature. | erythema multiforme, (em) an uncommon, acute inflammatory reactive mucocutaneous disorder and primary allergies confined to the oral mucosa. however the subsequent attacks can produce more severe forms of em involving the skin. manifestations of em are varied and present a diagnostic dilemma because infections (particularly herpes simplex and mycoplasma pneumoniae) and drugs seem to predispose towards development of em. we report two cases of em in which drugs (dioclofenac sodium & amoxycilline) ... | 2014 | 25386550 |
| a case of lethal hemolytic anemia associated with severe pneumonia caused by mycoplasma pneumoniae. | | 2014 | 25382347 |
| mympn: a database for the systems biology model organism mycoplasma pneumoniae. | mympn (http://mympn.crg.eu) is an online resource devoted to studying the human pathogen mycoplasma pneumoniae, a minimal bacterium causing lower respiratory tract infections. due to its small size, its ability to grow in vitro, and the amount of data produced over the past decades, m. pneumoniae is an interesting model organisms for the development of systems biology approaches for unicellular organisms. our database hosts a wealth of omics-scale datasets generated by hundreds of experimental a ... | 2015 | 25378328 |
| [seroprevalence of mycoplasma pneumoniae in poland in 2008-2013]. | mycoplasma pneumoniae is a common causative agent of tracheobronchitis and atypical pneumonia, mainly in children and adolescents. the infections are often seen as epidemics occurring in autumn-winter seasons at intervals of 4-7 years. epidemiological studies showed that m. pneumoniae is responsible for 30% to 40% of all cases of bacterial respiratory infections in poland. the aim of the study was estimate the seroprevalence of m. pneumoniae in poland in 2008-2013 in comparing to results obtaine ... | 2014 | 25369657 |
| effects of mycoplasma pneumoniae infection on airway neurokinin-1 receptor expression in balb/c mice. | the aim of this study was to establish a balb/c mouse model of mycoplasma pneumoniae (mp) infection and to explore the expression of neurokinin-1 receptor (nk1-r) in the trachea and lung tissue and changes in its relative content at different time points (on the 3rd, 7th, 14th, 21st, and 30th days after infection) in mp-infected balb/c mice. immunohistochemistry and western blot analysis were performed to determine nk1-r expression in the trachea and lung tissue and changes in relative content i ... | 2014 | 25366726 |
| investigations of mycoplasma pneumoniae infections in the united states: trends in molecular typing and macrolide resistance from 2006 to 2013. | mycoplasma pneumoniae is a leading cause of respiratory infections, including community-acquired pneumonia (cap). currently, pathogen-specific testing is not routinely performed in the primary care setting, and the united states lacks a systematic surveillance program for m. pneumoniae. documentation of individual cases and clusters typically occurs only when severe illness and/or failure to improve with empirical antibiotic therapy is observed. outbreaks, some lasting for extended periods and i ... | 2015 | 25355769 |
| [serum tumor necrosis factor-α, interleukin -6 and galctin-3 concentrations in children with mycoplasma pneumoniae pneumonia]. | to study the changes in serum tumor necrosis factor-α (tnf- α), interleukin-6 (il-6) and galctin-3 (gal-3) concentrations in children with mycoplasma pneumoniae pneumonia (mpp), and their roles in mpp. | 2014 | 25344180 |
| [features of lung dysfunction in children with mycoplasma pneumoniae pneumonia with different chest imaging findings]. | to explore the features of pulmonary dysfunction in children with mycoplasma pneumoniae pneumonia (mpp) with different chest imaging findings. | 2014 | 25344179 |
| lidocaine treatment in refractory status epilepticus resulting from febrile infection-related epilepsy syndrome: a case report and follow-up. | we report the management of refractory status epilepticus (se) by using continuous intravenous infusions of lidocaine in a previously healthy 15-year-old girl with a "catastrophic encephalopathy" in whom a diagnosis of febrile infection-related epilepsy syndrome was supposed. one week after a banal pharyngitis and fever, the patient presented confusion and intractable clusters of seizures. although she underwent multiple examinations investigating all possible etiologies (intracranial infection, ... | 2015 | 25343330 |
| the multivariate detection limit for mycoplasma pneumoniae as determined by nanorod array-surface enhanced raman spectroscopy and comparison with limit of detection by qpcr. | mycoplasma pneumoniae is a cell wall-less bacterial pathogen of the human respiratory tract that accounts for up to 20% of community-acquired pneumonia. at present, the standard for detection and genotyping is quantitative polymerase chain reaction (qpcr), which can exhibit excellent sensitivity but lacks standardization and has limited practicality for widespread, point-of-care use. we previously described a ag nanorod array-surface enhanced raman spectroscopy (na-sers) biosensing platform capa ... | 2014 | 25335653 |
| mycoplasma pneumoniae infection in hospitalized adult patients with community-acquired pneumonia in china. | this study aimed to investigate the prevalence, clinical and radiographic features, and antibiotic responses of mycoplasma pneumoniae (m. pneumoniae) infections in hospitalized adults with community-acquired pneumonia (cap) in china. | 2014 | 25313601 |
| clinical and epidemiological characteristics in children with community-acquired mycoplasma pneumonia in taiwan: a nationwide surveillance. | community-acquired pneumonia (cap) is the leading cause of hospitalization of children. mycoplasma pneumoniae is one of the most common pathogens. the disease severity is diverse, and the diagnosis remains a challenge to clinical pediatricians. the aims of this study are to provide a nationwide surveillance of the epidemiology and clinical manifestations of community-acquired mycoplasma pneumonia (camp) in children in taiwan. | 2015 | 25311405 |
| lesson of the month 1: pericardial mass and cardiac tamponade associated with mycoplasma pneumoniae. | mycoplasma pneumoniae primarily causes respiratory tract infections. extrapulmonary manifestations are seen in 20-25% of cases. cardiac involvement is rarely reported. we present a unique case of a pericardial mass and cardiac tamponade associated with a mycoplasma pneumoniae pneumonia. this required emergency pericardial fenestration. the patient improved dramatically postoperatively on antibiotics and there was no recurrence of the pericardial effusion on follow up. this case highlights the of ... | 2014 | 25301923 |
| role of cold agglutination test in the diagnosis mycoplasma pneumoniae infection in hiv infected children. | | 2014 | 25297041 |
| mycoplasma pneumoniae modulates stat3-stat6/egfr-foxa2 signaling to induce overexpression of airway mucins. | aberrant mucin secretion and accumulation in the airway lumen are clinical hallmarks associated with various lung diseases such as asthma, chronic obstructive pulmonary disease, and cystic fibrosis. mycoplasma pneumoniae, long appreciated as one of the triggers of acute exacerbations of chronic pulmonary diseases, has recently been reported to promote excessive mucus secretion. however, the mechanism of mucin overproduction induced by m. pneumoniae remains unclear. this study aimed to determine ... | 2014 | 25287927 |
| painless pediatric priapism and cough. | pediatric priapism can be a medical emergency but is not a common complaint seen in pediatric emergency department. priapism in a previously healthy child is also rare. we report a case of painless stuttering priapism associated with an acute mycoplasma pneumoniae infection in a previously healthy boy. | 2015 | 25285386 |
| [value of routine identification of respiratory infectious agents in children hospitalized with an acute asthma exacerbation]. | asthma is the most common chronic disease in childhood. with its high economic burden, it is considered a disease of major public health importance by the world health organization. the link between respiratory tract infections and acute exacerbation has been recognized for a long time. the aim of this retrospective study in routine care was to evaluate our practices concerning microbiological prescriptions in children hospitalized for asthma exacerbation. | 2014 | 25284733 |
| associations of radiological features in mycoplasma pneumoniae pneumonia. | the associations of radiological features with clinical and laboratory findings in mycoplasma pneumoniae infection are poorly understood. the purpose of this study was to assess the associations. | 2014 | 25276157 |
| mycoplasma pneumoniae infections--does treatment help? | mycoplasma pneumoniae is a common cause of respiratory tract infections (rti's), especially in children. while severe m. pneumoniae infections are generally treated with antibiotics, the diagnosis as well as treatment of these infections should be reconsidered in the light of recent clinical findings. first, m. pneumoniae was found to be carried in the upper respiratory tract of a relatively high percentage of healthy, asymptomatic children. clearly, this complicates the diagnosis of a suspected ... | 2014 | 25267596 |
| characteristics of mycoplasma pneumoniae infection identified on culture in a pediatric clinic. | the appropriate choice of antibiotics against mycoplasma pneumoniae infection has become difficult, as the prevalence of macrolide-resistant m. pneumoniae has increased. | 2015 | 25265270 |
| survey of macrolide-resistant mycoplasma pneumoniae in children with community-acquired pneumonia in switzerland. | | 2014 | 25254315 |
| a single-tube multiple-locus variable-number tandem-repeat analysis of mycoplasma pneumoniae clinical specimens by use of multiplex pcr-capillary electrophoresis. | in this study, we developed a single-tube multiple-locus variable-number tandem-repeat (vntr) analysis (mlva) assay to type mycoplasma pneumoniae directly from respiratory samples collected from children with respiratory infections. the multiplex pcr included four fluorescently primed vntrs (mpn13, mpn14, mpn15, and mpn16) and was carried out in a single tube. a total of 137 m. pneumoniae-positive specimens, collected in 2013 from beijing, china, were divided among four types (m4-5-7-2, m4-5-6-2 ... | 2014 | 25232156 |
| serial changes in serum eosinophil-associated mediators between atopic and non-atopic children after mycoplasma pneumoniae pneumonia. | mycoplasma pneumoniae pneumonia (mp) is associated with the exacerbation, timing, and onset of asthma. the goal of this study was to elucidate the impact of mp on eosinophil-related hyper-reactive amplification in atopic children. | 2014 | 25229000 |
| chest computed tomography for the diagnosis of mycoplasma pneumoniae infection. | we analysed 53 cases of laboratory-confirmed mycoplasma pneumoniae infection with cough lasting ≥ 7 days and chest radiography showing no abnormal findings. twenty-two (41%) of those patients showed abnormal findings on chest high-resolution computed tomography. in the daily clinical setting, for assessment of acute cough, physicians should be aware that it is difficult to confirm bronchiolitis or bronchopneumonia due to m. pneumoniae by chest radiography. | 2014 | 25219424 |
| chest pain in adolescent japanese male mimicking acute coronary syndrome. | acute chest pain with very elevated troponin level and abnormal ekg in adult population is considered sine qua non to acute coronary syndrome (acs) unless proved otherwise. similar presentation in adolescent population is seen less often but raises suspicion for acs. most common etiology for chest pain with cardiac enzyme elevation in adolescent population is usually viral myopericarditis. the adolescent population presenting with chest pain and elevated cardiac enzymes should be carefully evalu ... | 2014 | 25202456 |
| increased t cell activation in balf from children with mycoplasma pneumoniae pneumonia. | the mechanisms of mycoplasma pneumoniae induced lung inflammation are not clearly understood yet. this study investigated whether activated t cells in the airway contributed to the pulmonary inflammation in patients with severe mycoplasma pneumoniae pneumonia (mpp). | 2015 | 25157471 |
| gilles de la tourette syndrome caused by mycoplasma pneumoniae successfully treated with macrolides. | | 2014 | 25153913 |
| subcorneal pustular dermatosis associated with mycoplasma pneumoniae infection. | | 2014 | 25128138 |
| hemophagocytic lymphohistiocytosis secondary to mycoplasma pneumoniae infection without pneumonia. | mycoplasma pneumoniae typically causes respiratory tract infections, including pneumonia. we herein report the case of a 30-year-old japanese woman with hemophagocytic lymphohistiocytosis (hlh), which is rarely caused by bacteria, secondary to mycoplasma pneumoniae infection and ensuing hypercytokinemia without pneumonia who was successfully treated with a combination of antibiotics and corticosteroids. therefore, mycoplasma pneumoniae infection, which is treatable with antibiotics, should be co ... | 2014 | 25088886 |
| community-acquired pneumonia caused by macrolide-resistant mycoplasma pneumoniae in adults. | we herein describe a case of community-acquired pneumonia caused by macrolide-resistant mycoplasma pneumoniae (mrmp) in an adult who responded poorly to macrolide antibiotics, progressively deteriorated to acute respiratory failure and then responded effectively to a fluoroquinolone. in a series of 14 patients with m. pneumoniae pneumonia, 11 were infected with mrmp. in seven of the eight cases of mrmp initially treated with macrolides, the patients did not improve, and a marked improvement was ... | 2014 | 25088885 |
| increased risk of refractory mycoplasma pneumoniae pneumonia in children with atopic sensitization and asthma. | a nationwide outbreak of mycoplasma pneumoniae pneumonia (mp) refractory to macrolide antibiotics occurred in korea during 2011. steroid therapy has been reported to be both efficacious and well tolerated in pediatric patients with refractory mp. we compared clinical features and laboratory characteristics between children with refractory mp requiring steroid treatment and those with macrolide-responsive mp and evaluated the risk factors associated with refractory mp. | 2014 | 25076972 |
| mycoplasma pneumoniae cards toxin exacerbates ovalbumin-induced asthma-like inflammation in balb/c mice. | mycoplasma pneumoniae causes a range of airway and extrapulmonary pathologies in humans. clinically, m. pneumoniae is associated with acute exacerbations of human asthma and a worsening of experimentally induced asthma in mice. recently, we demonstrated that community acquired respiratory distress syndrome (cards) toxin, an adp-ribosylating and vacuolating toxin synthesized by m. pneumoniae, is sufficient to induce an asthma-like disease in balb/cj mice. to test the potential of cards toxin to e ... | 2014 | 25058417 |
| layer-by-layer polyelectrolyte encapsulation of mycoplasma pneumoniae for enhanced raman detection. | mycoplasma pneumoniae is a major cause of respiratory disease in humans and accounts for as much as 20% of all community-acquired pneumonia. existing mycoplasma diagnosis is primarily limited by the poor success rate at culturing the bacteria from clinical samples. there is a critical need to develop a new platform for mycoplasma detection that has high sensitivity, specificity, and expediency. here we report the layer-by-layer (lbl) encapsulation of m. pneumoniae cells with ag nanoparticles in ... | 2014 | 25017005 |
| [clinical features and pathogens of plastic bronchitis in children: an analysis of 9 cases]. | to study the clinical features and pathogens of plastic bronchitis in children. | 2014 | 25008882 |
| bilateral monosymptomatic optic neuritis following mycoplasma pneumoniae infection: a case report and literature review. | herein, we report the clinical findings, treatment choice, and clinical course of a rare case of mycoplasma pneumoniae (m. pneumoniae) infection with the sole manifestation of optic neuritis (on). to the best of our knowledge, this is the first case presenting monosymptomatic visual loss without papillitis, neurological symptoms, and abnormal findings on brain imaging. related articles about on after m. pneumoniae infection were reviewed to summarize the clinical presentation, possible mechanism ... | 2014 | 25005204 |
| lung abscess in a child secondary to mycoplasma pneumoniae infection. | we present a case of a lung abscess in a child 6-year-old admitted with a history of right hemithorax pain lasting for 15 days and the onset of mild fever in the last two days. etiological research showed positivity of igm antibodies to mycoplasma pneumoniae after seven days of admission. the child has been successfully treated with antibiotic therapy, without the use of macrolides, for a duration of 4 weeks. our study suggests that the mycoplasma pneumoniae infection may predispose to severe in ... | 2014 | 25004644 |
| mycoplasma pneumoniae infection in children is a risk factor for developing allergic diseases. | mycoplasma pneumoniae (mp) infection is the dominant cause of pneumonia in children. we sought to determine the relationship between mp infection and secondary allergic disease and to clarify the associated mechanisms of inflammatory response. a prospective study was performed among 1330 patients diagnosed with pneumonia to investigate the patient immune status by determining the correlation between mp infection, immunoglobulin e (ige) levels, and a spectrum of associated serum cytokines. serum ... | 2014 | 24977240 |
| [mycoplasma pneumoniae-associated mucositis: a case report]. | | 2014 | 24969943 |
| [clinical analysis of 2 cases with chylothorax due to primary lymphatic dysplasia and review of literature]. | to analyze the clinical characteristics and diagnosis of 2 cases with chylothorax due to primary lymphatic dysplasia and to elevate pediatrician's recognition level for this disease. | 2014 | 24969935 |
| effects of bronchoalveolar lavage on refractory mycoplasma pneumoniae pneumonia. | this study prospectively evaluated the effect of early bronchoalveolar lavage (bal) on refractory mycoplasma pneumoniae pneumonia with radiologically proven large pulmonary lesions in children. | 2014 | 24962224 |
| antibody responses to mycoplasma pneumoniae: role in pathogenesis and diagnosis of encephalitis? | | 2014 | 24945969 |
| mycoplasma pneumoniae thymidine phosphorylase. | mycoplasma pneumoniae (mpn) is a human pathogen causing acute respiratory diseases and accounts for approximately 30% cases of community-acquired pneumonia. co-infection with mycoplasmas compromises the efficacy of anticancer and antiviral nucleoside analog-based drugs due to the presence of mycoplasma thymidine phosphorylase (tp). in this study, a tp-deficient strain of mpn was generated in order to study the effect of mpn tp in the metabolism of nucleoside analogs. deficiency in tp activity le ... | 2014 | 24940683 |
| novel strategy for typing mycoplasma pneumoniae isolates by use of matrix-assisted laser desorption ionization-time of flight mass spectrometry coupled with clinprotools. | the typing of mycoplasma pneumoniae mainly relies on the detection of nucleic acid, which is limited by the use of a single gene target, complex operation procedures, and a lengthy assay time. here, matrix-assisted laser desorption ionization-time of flight mass spectrometry (maldi-tof ms) coupled to clinprotools was used to discover maldi-tof ms biomarker peaks and to generate a classification model based on a genetic algorithm (ga) to differentiate between type 1 and type 2 m. pneumoniae isola ... | 2014 | 24920781 |
| increasing the precision of orthology-based complex prediction through network alignment. | macromolecular assemblies play an important role in almost all cellular processes. however, despite several large-scale studies, our current knowledge about protein complexes is still quite limited, thus advocating the use of in silico predictions to gather information on complex composition in model organisms. since protein-protein interactions present certain constraints on the functional divergence of macromolecular assemblies during evolution, it is possible to predict complexes based on ort ... | 2014 | 24918034 |
| relevance of serology for mycoplasma pneumoniae infection among children with persistent cough. | mycoplasma pneumoniae is an important cause of upper and lower respiratory tract infections. cough and tracheobronchitis are the commonest features of m. pneumoniae infection but diagnosis based on clinical symptoms that may be due to other respiratory pathogens is impossible. thus laboratory testing for m. pneumoniae is particularly important. correct and rapid diagnosis of m. pneumoniae infections is of prime importance to introduce appropriate antibiotic treatment. | 2014 | 24913108 |
| acute small fiber neuropathy following mycoplasma infection: a rare variant of guillain-barré syndrome. | guillain-barré syndrome (gbs) is a well-described condition involving the peripheral nervous system. the most well-known form of this disease is acute inflammatory demyelinating polyradiculoneuropathy. among the different variants of gbs described in the literature, the sensory variant is scantily recognized. there has been a recent attempt to classify the sensory variants of the gbs and bring more objectivity to this diagnostic paradigm. we report a rare sensory variant of gbs presenting with i ... | 2014 | 24872212 |
| predictive value of c-reactive protein in response to macrolides in children with macrolide-resistant mycoplasma pneumoniae pneumonia. | the prevalence of macrolide-resistant mycoplasma pneumoniae (mrmp) has increased worldwide. the aim of this study was to estimate the proportion of mrmp in a tertiary hospital in korea, and to find potential laboratory markers that could be used to predict the efficacy of macrolides in children with mrmp pneumonia. | 2014 | 24868216 |
| treatment of mycoplasma pneumonia: a systematic review. | children with community-acquired lower respiratory tract infection (ca-lrti) commonly receive antibiotics for mycoplasma pneumoniae. the objective was to evaluate the effect of treating m. pneumoniae in children with ca-lrti. | 2014 | 24864174 |
| treatment of mycoplasma pneumoniae in pediatric lower respiratory infection. | | 2014 | 24864169 |
| relationships between the varied ciliated respiratory epithelium abnormalities and severity of mycoplasma pneumoniae pneumonia. | the pathogenesis of mycoplasma pneumoniae infection involves cytoadherence of m. pneumoniae to the ciliated respiratory epithelium (cre), followed by cre injury caused by the m. pneumoniae. however, whether cre abnormalities are related to the severity of m. pneumoniae pneumonia (mp) remains to be determined. | 2014 | 24856893 |
| [clinical features and treatment of refractory mycoplasma pneumoniae pneumonia unresponded to conventional dose methylprednisolone in children]. | to analyze the clinical manifestations of refractory mycoplasma pneumoniae pneumonia (rmpp) which unresponded to methylprednisolone in the dosage of 2 mg/(kg·d) for 3 days. | 2014 | 24824385 |
| recurrent stevens-johnson syndrome secondary to mycoplasma pneumoniae infection. | | 2014 | 24818190 |
| the role of mycoplasma pneumoniae infection in the initial onset and exacerbations of asthma. | asthma is a disease in which airway hyperresponsiveness, increased airway contraction, and airway secretion occur as a result of allergic airway inflammation. mycoplasma infections are well known to exacerbate asthma pathology as well as to cause the onset of asthma itself. mechanisms of airway epithelial injury, activation of innate immunity, or increased th2-dominant immune responses caused by community-acquired distress syndrome toxin (cardstx) or diacylated lipoprotein have been reported in ... | 2016 | 24801462 |
| [two cases of mycoplasma pneumoniae bronchopneumonia diagnosed with lamp (loop-mediated isothermal amplification) as a rapid assay]. | mycoplasma pneumoniae is one of the common pathogens of the community-acquired pneumonia in adults and children. macrolide antibiotics are considered to be the first-choice drug for m. pneumoniae infections. however, macrolide-resistant m. pneumoniae was first detected from japanese pediatric patients in 2000,and it has been increasing over the past decade. on the other hand, the immunocard mycoplasma igm test is widely used as a rapid and easy diagnostic method for m. pneumoniae pneumonia, but ... | 2014 | 24783458 |
| single-nucleotide polymorphism pcr for the detection of mycoplasma pneumoniae and determination of macrolide resistance in respiratory samples. | the aim of this study was to develop a single-nucleotide polymorphism (snp) pcr assay to be performed directly on respiratory samples for the simultaneous detection of mycoplasma pneumoniae and its 23s rrna gene mutations, which are responsible for macrolide resistance. for multiplex snp pcr, two outer primers for amplification of the 23s rrna gene and two mutant-specific primers for the discrimination of single base changes were designed. a total of 73m. pneumoniae-positive samples and 100m. pn ... | 2014 | 24780151 |
| mycoplasma pneumoniae in children: carriage, pathogenesis, and antibiotic resistance. | both the diagnosis and treatment of mycoplasma pneumoniae infections in children are currently facing two main challenges: a relatively high carriage in asymptomatic children, and a worldwide increase in macrolide-resistant m. pneumoniae (mrmp). this review focuses on the scientific and clinical implications of these crucial issues. | 2014 | 24751894 |
| [clinical efficacy of adjuvant therapy with glucocorticoids in children with lobar pneumonia caused by mycoplasma pneumoniae]. | to study the clinical efficacy of adjuvant therapy with glucocorticoids in children with lobar pneumonia caused by mycoplasma pneumoniae. | 2014 | 24750839 |
| real-time pcr detection of mycoplasma pneumoniae in the diagnosis of community-acquired pneumonia. | polymerase chain reaction is a useful technique in microbial diagnostics to detect and quantify dna or rna of low abundance. bacterial and viral nucleic acid can be amplified by pcr upon clinical sample extraction using specific primers for classical qualitative pcr and primers and probes for real-time pcr. here we describe the scorpion-probe real-time pcr-based assay that offers thermodynamic advantages due to its kinetic reaction and provides faster performances compared to a classical double- ... | 2014 | 24740224 |
| climate variability and nonstationary dynamics of mycoplasma pneumoniae pneumonia in japan. | a stationary association between climate factors and epidemics of mycoplasma pneumoniae (m. pneumoniae) pneumonia has been widely assumed. however, it is unclear whether elements of the local climate that are relevant to m. pneumoniae pneumonia transmission have stationary signatures of climate factors on their dynamics over different time scales. | 2014 | 24740102 |
| association of serum clara cell protein cc16 with respiratory infections and immune response to respiratory pathogens in elite athletes. | respiratory epithelium integrity impairment caused by intensive exercise may lead to exercise-induced bronchoconstriction. clara cell protein (cc16) has anti-inflammatory properties and its serum level reflects changes in epithelium integrity and airway inflammation. this study aimed to investigate serum cc16 in elite athletes and to seek associations of cc16 with asthma or allergy, respiratory tract infections (rtis) and immune response to respiratory pathogens. | 2014 | 24735334 |
| erythema multiforme associated with mycoplasma pneumoniae. | | 2014 | 24728737 |
| typical or atypical pneumonia and severe acute respiratory symptoms in picu. | mycoplasma pneumoniae (mp) is a common childhood pathogen associated with atypical pneumonia (ap). it is often a mild disease and seldom results in paediatric intensive care (picu) admission. in 2003, world health organization (who) coined the word sars (severe acute respiratory syndrome) in patients with severe acute respiratory symptoms (sars) for an outbreak of ap in hong kong due to a novel coronavirus. in 2012, another outbreak of coronavirus ap occurred in the middle east. confusing case d ... | 2015 | 24720856 |
| early treatment with corticosteroids in patients with mycoplasma pneumoniae pneumonia: a randomized clinical trial. | corticosteroids have been evaluated for management of severe mycoplasma pneumoniae pneumonia (mp) in children. however, it is unclear whether the timing of treatment with corticosteroids affects the patients' clinical outcome. | 2014 | 24710342 |
| surveillance of mycoplasma pneumoniae infection among children in beijing from 2007 to 2012. | mycoplasma pneumonia (m. pneumoniae) is one of the key pathogens of community-acquired pneumonia. a global pandemic of m. pneumoniae has occurred since 2010. the aim of this study was to survey the prevalence of m. pneumoniae in children in beijing from 2007-2012. | 2014 | 24709174 |
| parainfectious optic neuritis: manifestations in children vs adults. | parainfectious optic neuritis may appear at any age. the aim of our report was to compare the clinical manifestations and outcomes of this form of optic neuritis between children and adults. | 2014 | 24667772 |
| mycoplasma pneumoniae-associated mucositis--case report and systematic review of literature. | mycoplasma pneumoniae, a bacterium known to be a common cause of pneumonia, has been documented to cause complications such as debilitating mucositis previously described as an atypical stevens-johnson syndrome without skin lesions. however, in the spectrum of epidermal dermatopathies, the condition is increasingly recognized as a separate entity, now termed m. pneumoniae-associated mucositis (mpam). | 2015 | 24665876 |
| [effect of mycoplasma pneumoniae infection on function of t lymphocytes in bronchoalveolar lavage fluid of asthmatic children]. | to investigate the effect of mycoplasma pneumoniae (mp) infection on the function of t lymphocytes in the bronchoalveolar lavage fluid (balf) of asthmatic children in acute and stable periods and the relationship between mp infection and asthma. | 2014 | 24661521 |
| mycoplasma pneumoniae infection with rhabdomyolysis in a child. | we report the history of a seven year-old male boy with cough and fever, who developed rhabdomyolysis concomitant with mycoplasma pneumoniae infection. the association between this organism and the muscular injury is rarely described in paediatric patients. this case then thus emphasizes that even seemingly mild m. pneumoniae airway infections may be complicated by invalidating neuromuscular sequelae. | 2014 | 24651091 |
| clinical significance of different bacterial load of mycoplasma pneumoniae in patients with mycoplasma pneumoniae pneumonia. | this retrospective study was conducted to investigate the clinical significance of different mycoplasma pneumoniae bacterial load in patients with m. pneumoniae pneumonia (mp) in children. | 2014 | 24650994 |
| subcorneal pustular dermatosis triggered by mycoplasma pneumoniae infection: a rare clinical association. | | 2015 | 24650287 |
| [extrarespiratory manifestations of mycoplasma pneumoniae: a case report]. | extrapulmonary manifestations of mycoplasma pneumoniae are sometimes severe and may even be life-threatening. a 10-year-old patient was hospitalized due to a flu-like illness lasting 48 h with impaired general condition, after an extended stay in africa. there was an inflammatory syndrome associated with hyponatremia, but malaria was negative. a triple antibiotic therapy with ceftriaxone, amikacin, and josamycin was started. the progression was marked by the appearance of hypoxemia pneumoniae as ... | 2014 | 24630540 |
| [clinical assessment cannot predict if children are infected with mycoplasma pneumoniae]. | this meta-analysis was carried out to detect if clinical signs can predict infection with mycoplasma pneumoniae in children. the only significant finding was that absence of wheezing was associated with m. pneumoniae-infection. the analysis does not justify changes in the recommendation regarding treatment of pneumonia in children. empiric therapy with macrolides can only be recommended if the patient does not tolerate betalactam. | 2013 | 24629438 |
| mycoplasma pneumonia-associated mucositis. | we present a case of a young man with severe mucositis following an upper respiratory tract infection limited to the ophthalmic and oral mucosa while sparing the rest of the skin, genitalia and perianal regions. investigations revealed that the mucositis was a rare extrapulmonary manifestation of mycoplasma pneumoniae infection. he had progressive vision-threatening symptoms despite antibiotics and best supportive care and thus was treated with intravenous corticosteroids, immunoglobulins, tempo ... | 2014 | 24626386 |
| genetic point-of-care diagnosis of mycoplasma pneumoniae infection using lamp assay. | mycoplasma pneumoniae (mp) is a major pathogen of lower respiratory tract infection (lrti) in children. a rapid diagnostic method during the acute phase is required for the prescription of effective antibiotics. | 2014 | 24612134 |
| drug resistance mechanisms of mycoplasma pneumoniae to macrolide antibiotics. | throat swabs from children with suspected mycoplasma pneumoniae (m. pneumoniae) infection were cultured for the presence of m. pneumoniae and its species specificity using the 16s rrna gene. seventy-six m. pneumoniae strains isolated from 580 swabs showed that 70 were erythromycin resistant with minimum inhibitory concentrations (mic) around 32-512 mg/l. fifty m. pneumoniae strains (46 resistant, 4 sensitive) were tested for sensitivity to tetracycline, ciprofloxacin, and gentamicin. tetracyclin ... | 2014 | 24592385 |