| [algorithm for examination of children and adolescents with hyperergic tuberculin susceptibility]. | to improve the diagnosis of minor forms of intrathoracic tuberculosis in patients with hyperergic tuberculin susceptibility, clinical, laboratory, and radiological studies (chest computed tomography) were conducted in 147 children and adolescents. the studies revealed local tuberculosis in 42.2% of cases, mycobacterium tuberculosis infection with hyperergic tuberculin susceptibility in 49.6%, and a paraallergic reaction to tuberculin in 8.2%. the findings have permitted an algorithm to be develo ... | 2010 | 27529926 |
| new, easy-to-use tools for standardised and quality-controlled genotyping of mycobacterium tuberculosis complex strains. | | 2010 | 25965937 |
| regulation of mycobacterium tuberculosis cell wall lipid composition and its effects on in vitro bacterial persistence. | | 2010 | 25965928 |
| evolutionary forces in mycobacterium tuberculosis. | | 2010 | 25965925 |
| idiopathic granulomatous mastitis-utility of fine needle aspiration cytology (fnac) in preventing unnecessary surgery. | granulomatous mastitis is a benign disorder which closely mimics malignancy clinico-radiologically. a simple and cost effective modality like fine needle aspiration cytology (fnac) can help in prompt diagnosis and avoid unnecessary surgery. | 2010 | 24591917 |
| primary tuberculous lymphadenitis: a case report. | tuberculosis (tb) is a prevalent systemic bacterial infectious disease usually caused by mycobacterium tuberculosis. it is estimated that approximately 8 million people develop tb each year, and 3 million people die of complications associated with the disease. in this article we report a case of a 17-year-old female patient with a painful swelling in her right submandibular region. she was diagnosed with right submandibular tuberculous lymphadenitis. tuberculous lymphadenitis, when occurring in ... | 2010 | 23662079 |
| utility of serum ldh isoforms in the assessment of mycobacterium tuberculosis induced pathology in tb patients of sahariya tribe. | the present study was carried out in the sahariya tribe of central india, which reportedly have high prevalence of pulmonary tuberculosis. total serum ldh and its tissue specific isoforms were estimated in tb patients and matched healthy controls to test the utility of ldh as diagnostic marker for tuberculosis. about 210 sputum positive cases and 328 age and sex matched sputum negative controls were recruited. the spectrophotometeric and densitometric analysis of each ldh isoform was carried out ... | 2010 | 23105885 |
| low occurrence of tuberculosis drug resistance among pulmonary tuberculosis patients from an urban setting, with a long-running dots program in zambia. | we set out to determine the levels of mycobacterium tuberculosis resistance to first- and second-line tb drugs in an urban population in zambia. sputum samples were collected consecutively from all smear-positive, new and previously treated patients, from four diagnostic centres in ndola between january and july 2006. drug susceptibility testing was performed using the proportion method against four first- and two second-line tb drugs. results. among 156 new cases, any resistance was observed to ... | 2010 | 22567261 |
| examining the sublineage structure of mycobacterium tuberculosis complex strains with multiple-biomarker tensors. | strains of the mycobacterium tuberculosis complex (mtbc) can be classified into coherent lineages of similar traits based on their genotype. we present a tensor clustering framework to group mtbc strains into sublineages of the known major lineages based on two biomarkers: spacer oligonucleotide type (spoligotype) and mycobacterial interspersed repetitive units (miru). we represent genotype information of mtbc strains in a high-dimensional array in order to include information about spoligotype, ... | 2010 | 22466374 |
| epidemiology of clinical isolates of mycobacterium tuberculosis at ibadan, nigeria. | despite the huge burden of tuberculosis (tb) in nigeria, case detection rate of infectious cases still remain low, thus constituting obstacle to eradication of the disease in the community. we carried out a 15 month (1st january 2008 to 30th march 2009) retrospective review of epidemiology of clinical isolates of m. tuberculosis isolated at tb regional reference laboratory at the department of medical microbiology and parasitology, university college hospital, ibadan, nigeria. fifty isolates wer ... | 2010 | 22314952 |
| detection of non-amplified mycobacterium tuberculosis genomic dna using piezoelectric dna-based biosensors. | piezoelectric dna-based biosensor technology was developed as a new method for detection of m. tuberculosis. this method consists of immobilizing a thiol-modified oligonucleotide probe on the gold electrode surface of a quartz crystal, using a self-assembled monolayer method. the advantage of this study is that a non-amplified genomic bacterial dna target was used. instead, the genomic dna was digested by restriction enzyme to obtain dna fragments containing the target sequence. the fabricated b ... | 2010 | 22294903 |
| laparoscopic peritoneal biopsy can be crucial for diagnosis of tuberculous peritonitis. | a 28-year-old woman was admitted to a nearby hospital because of low-grade fever and lower abdominal pain, where ascites and slightly elevated serum ca125 level were found. both acid-fast stain (afs) and polymerase chain reaction (pcr) failed to detect mycobacterium tuberculosis in her ascitic fluid, sputum, and gastric juice. she was referred to our division under suspicion of tuberculous peritonitis or ovarian carcinoma. finally, diagnostic laparoscopy was carried out, showing yellowish-white ... | 2009 | 26192796 |
| characterization of molecular evolution in multi-drug resistant of mycobacterium tuberculosis by rpob gene in patient with active pulmonary tuberculosis from iranian isolates. | this is the first genetic biodiversity study of mycobacterium tuberculosis in iran. thus, we investigated the genetic patterns of strains isolated in the first survey of anti-tuberculosis drug-resistance by rpob gene as part of the global project of anti-tuberculosis drug resistance surveillance (iau, iran). a 411-bp fragment of the rpob gene, containing the sequence of the 81-bp rpob fragment, was amplified by pcr and the rpob gene fragments of tuberculosis strains were sequenced using the amer ... | 2009 | 23675155 |
| [managing mycobacterium tuberculosis infection and disease in patients with steroids or immunosuppressive drugs]. | | 2009 | 19896754 |
| review of knowledge for rational design and identification of anti-tubercular compounds. | the synergy between tuberculosis and the aids epidemic, along with the surge of multi-drug resistant isolates of mycobacterium tuberculosis, has reaffirmed tuberculosis as a primary public health threat. discovery of novel anti-tubercular entities is a highly complex and, therefore, more rational design strategies based on our increasing understanding of the fundamental principles of protein-ligand interactions are required. the combination of available knowledge of several 3d protein structures ... | 2009 | 23480394 |
| prevalence of pulmonary tuberculosis (ptb) among people living with hiv/aids (plwha) in keffi and its environs. | coinfection with hiv and mycobacterium tuberculosis is known to be a lethal combination especially with its attendant mortality and morbidity. the need to have a baseline data in an environment like keffi with a hiv/aids prevalence of 38.6% necessitated this study. three hundred and ninety people living with hiv/aids (plwha) were screened for pulmonary tuberculosis. results of this study showed 16.7% prevalence of coinfection in the population. gender-related prevalence of coinfection was 19.4% ... | 2009 | 23100775 |
| template registration with missing parts: application to the segmentation of m. tuberculosis infected lungs. | many techniques have been proposed to segment organs from images, however the segmentation of diseased organs remains challenging and frequently requires lots of user interaction. the challenge consists of segmenting an organ while its appearance and its shape vary due to the presence of the disease in addition to individual variations. we propose a template registration technique that can be used to recover the complete segmentation of a diseased organ from a partial segmentation. the usual tem ... | 2017 | 26146531 |
| characterization of mycobacterium tuberculosis complex isolated from iranian and afghani patients by spoligotyping method. | designing newer drugs, vaccines, and diagnostic techniques is dependent on better understanding of m. tuberculosis virulence mechanism. in this study the prevalence of pcaa gene was determined in m. tuberculosis strains typed by spoligotyping. the associated risk factors among patients with different nationalities residing in iran were also determined. the isolated m. tuberculosis strains have been characterized by performing susceptibility tests against four first-line antituberculosis drugs an ... | 2009 | 24031364 |
| a utility script for automating and integrating autodock and other associated programs for virtual screening. | autodock is one of the most widely used docking programs but, is under utilized for the purpose of virtual screening. in order to overcome the difficulties that arise during virtual screening with autodock especially for gui users an attempt is taken to automate the entire docking process, starting from grid map generation through ligand preparation and finally docking. additional features from software like filter, omega, rocs and eon are also incorporated to create a complete virtual screening ... | 2009 | 20198176 |
| evaluation of the results of mycobacterium tuberculosis direct test (mtd) and mycobacterial culture in urine samples. | tuberculosis remains a public health problem in turkey. rapid detection of mycobacterium tuberculosis plays a key role in control of infection. in this article, the gen-probe amplified mycobacterium tuberculosis direct test (mtd) was evaluated for detection of m. tuberculosis in urine samples. the performance of the mtd was very good and appropriate for routine laboratory diagnosis. | 2008 | 24031287 |
| evaluation of methods for detection and identification of mycobacterium species in patients suspected of having pulmonary tuberculosis. | tuberculosis control is a priority for the ministry of health policies in brazil. in the present work, the detection of mycobacterium tuberculosis by the polymerase chain reaction (pcr) was standardized, and the laboratory diagnosis of pulmonary tuberculosis was evaluated comparing baciloscopy, culture and pcr tests. the study was carried out with 117 sputum samples from different patients suspected of having pulmonary tuberculosis, for whom physicians had ordered a baciloscopy test. baciloscopy ... | 2008 | 24031276 |
| detection and characterization of nocardia from patients diagnosed as tuberculosis in egypt. | pulmonary tuberculosis and pulmonary nocardiosis are similar in most clinical symptoms and radiological manifestation. in the developing countries like egypt where tuberculosis is very common, anti-tuberculosis drugs are started on basis of radiology and clinical symptoms. this study included 600 sputum specimens collected from 200 patients diagnosed as pulmonary tuberculosis from three chest hospitals in egypt. is6110 specific primer were selected for pcr to identify the mycobacterium tuberculo ... | 2008 | 23675087 |
| improved diagnosis of central nervous system tuberculosis by mpb64-target pcr. | central nervous system (cns) tuberculosis is a serious clinical problem, the treatment of which is sometimes hampered by delayed diagnosis. clearly, prompt laboratory diagnosis is of vital importance as the spectrum of disease is wide and abnormalities of the cerebrospinal fluid (csf) are incredibly variable. since delayed hypersensitivity is the underlying immune response, bacterial load is very low. the conventional bacteriological methods rarely detect mycobacterium tuberculosis in csf and ar ... | 2008 | 24031203 |
| reactivation mycobacterium tuberculosis presenting as empyema necessitans 55 years following thoracoplasty. | we describe the case of a 79-year-old man who presented with an enlarging mass on his chest wall. he had a history of thoracoplasty performed 55 years ago for treatment of pulmonary tuberculosis. the mass was subsequently proven to be the result of empyema neccesitans caused by reactivation tuberculosis. empyema neccesitans is a well described entity in which an empyema spontaneously decompresses by dissecting into the chest wall and extrathoracic soft tissues. this can occur following necrotizi ... | 2008 | 27303540 |
| testicular tuberculosis without epididymitis simulating neoplasm. | we present the case of a 47-year-old man with testicular tuberculosis without epididymal involvement that simulated neoplasm on sonography. the patient also had evidence of contralateral spermatic cord involvement. the diagnosis was made following transinguinal intrascrotal exploration and excisional biopsy of the left spermatic cord mass and right transinguinal radical orchiectomy. histopathology showed caseating granulomatous inflammation, with positive cultures for mycobacterium tuberculosis ... | 2008 | 27303531 |
| approach for the simulation and modeling of flexible rings: application to the α-d-arabinofuranoside ring, a key constituent of polysaccharides from mycobacterium tuberculosis. | a number of lower organisms (bacteria, fungi, and parasites) produce glycoconjugates that contain furanose rings. of particular interest to our group are cell wall polysaccharides from mycobacteria, including the human pathogen, mycobacterium tuberculosis, which contain a large number of arabinofuranose resides. as part of a larger project on the conformational analysis of these molecules, we report here molecular dynamics simulations on methyl α-d-arabinofuranoside (1) using the amber force fie ... | 2008 | 25339852 |
| comparative evaluation of the nitrate reductase assay and the resazurin microtitre assay for drug susceptibility testing of mycobacterium tuberculosis against first line anti-tuberculosis drugs. | tuberculosis remains as a serious infection disease of worldwide distribution, with high morbidity and mortality, mainly in low socio-economic condition countries. the state of emergency of tuberculosis caused by the resistant and multidrug-resistant (mdr) strains, became the main threat to the tuberculosis treatment and control programs. a fast detection method for the resistant strains will allow the implementation of an adequate treatment and contribute for controlling the dissemination of th ... | 2008 | 24031169 |
| development of new antituberculous agents based on new drug targets and structure-activity relationship. | tuberculosis, especially multi-drug resistant tuberculosis, is an important global health concern and the development of new antituberculous drugs is urgently needed. this article deals with the following areas: first, the present status of the development of new antituberculous drugs is reviewed, discussing new promising antituberculous agents, such as nitroimidazoles, diarylquinolines and oxazolidinones; and second, the future development of new antituberculous drugs is discussed according to ... | 2008 | 23480138 |
| [tuberculosis pulmonum--"threaten us of epidemic"?]. | tuberculosis (tb) remains a deadly infectious disease affecting millions of people worldwide with 95% of cases and 98% of deaths occuring in developing countries (9 milion new cases, 1 million deaths annually) vs.who. tuberculosis is on the increase in developed countries, because of aids, the use of immunosuppresive drugs which depress the host defence mechanism, decreased socioeconomic conditions, as well as increased immigration of persons from areas of high endemicity. the major reason for t ... | 2008 | 22320031 |
| use of a novel multiplex probe array for rapid identification of mycobacterium species from clinical isolates. | conventional identification of mycobacteria is based on the analysis of their phenotypic and biochemical characteristics after culture; thus this method is time-consuming, laborious, and is not always conclusive. developing a fast and accurate method for rapid identification of mycobacterium species is in urgent need for early diagnosis of mycobacteriosis and effective patient management. in this study, an efficient and affordable novel multiplex probe array which allows simultaneous identificat ... | 2007 | 27517834 |
| 2-chloro-6-(2-furyl)-9-(4-methoxybenzyl)-9h-purine. | the title compound, c(17)h(13)cln(4)o(2), displays profound and selective activity against mycobacterium tuberculosis. in the crystal structure, there are two independent molecules in the asymmetric unit. intermolecular hydrogen bonding between a ch group of the purine ring and the o atom of the furan ring, and also pi-pi stacking in another direction, builds the three-dimensional network. | 2007 | 17478910 |
| [new diagnosis tools for tuberculosis laboratory network in latin america]. | feasibility of rapid and sustainable diagnostic methods that provide useful and timely results to guide the clinical control of tuberculosis patients was analyzed. however, policies guiding the insertion of new diagnostics in the laboratory services that support the tuberculosis control are lacking in developing countries. the introduction of these methods in developing countries laboratories requires rational policies guiding the application of these technologies. in the last few years, some au ... | 2013 | 23427439 |
| resistance to antituberculosis drugs in pulmonary tuberculosis. | incidence of drug resistance and pattern of susceptibility to antitubercular drugs in pulmonary tuberculosis amongst soldiers and their families was studied for four years at a military hospital in northwest india. | 2006 | 27688532 |
| evaluation of polymerase chain reaction for rapid diagnosis of clinically suspected tuberculous pleurisy. | pleural effusion is one of the commonest presentations of tuberculosis, the clinical manifestations being typically abrupt resembling bacterial pneumonia. since delayed hypersensitivity is the underlying immune response, bacterial load is very low. owing to these facts, tuberculous pleurisy as an extra-pulmonary disease poses a diagnostic dilemma. the conventional bacteriological methods rarely detect mycobacterium tuberculosis in pleural fluid and are of limited use in diagnosis of tuberculous ... | 2006 | 23105619 |
| asymptomatic pons tuberculoma in an infant with miliary tuberculosis. | miliary tuberculosis is caused by the hematogenous spread of mycobacterium tuberculosis and consists of 1.5% of all tuberculosis cases. it is seen mostly in infants because of the immature immune system, and central nervous system (cns) involvement is not rare. tuberculomas are rarely seen in the localized form of cns tuberculosis, and only 4% are localized in the brain stem. we report a 4.5-month-old infant who deteriorated during follow-up with the diagnosis of cytomegalovirus pneumonia, and a ... | 2005 | 22473146 |
| study of drug resistant pulmonary tuberculosis. | drug resistance has emerged as a major problem in management of pulmonary tuberculosis (pt) with increase in its incidence. | 2005 | 27407770 |
| diagnostic role of the antibody response to the 38kda, 16kda proteins and lipoarabinomannan of mycobacterium tuberculosis. | the antibody response to the 38kda, 16kda and lipoarabinomannan (lam) antigens ofmycobacterium tuberculosis was evaluated using three different elisas based on these antigens. the study group included tuberculosis patients (n=52), patients with hiv and tb co-infection (n=10), other chest symptomatics (n=5), hiv infected individuals (n=10), leprosy cases (n=7) and healthy controls (n=75). the results indicate that the 38kda and lam based elisa for igm/igg has a low specificity (ranging from 69-85 ... | 2005 | 23105508 |
| haematogenous spread of pulmonary tuberculosis to a hemiarthroplasty of the hip. | tuberculosis (tb) in a joint arthroplasty is unusual, and is usually due to reactivation from a previously infected joint or rarely from endogenous spread. we present a patient with septic loosening of a cemented thompsons hemiarthroplasty due to mycobacterium tuberculosis infection seven years post-operatively. at the time of surgery he had no symptoms or signs of tb. there have been no such reported cases in the english medical literature. (hip international 2004; 14: 258-61). | 2017 | 28247402 |
| mycobacterial genetics in target validation. | one-third of the world's population is infected with mycobacterium tuberculosis and tb claims 2 million lives every year, yet no new first-line anti-tb drugs have been introduced since 1970. the urgent need to find new agents to reduce the duration and complexity of tb chemotherapy and to eradicate persistent infection is reinforced by the emergence of multi-drug resistant strains and the hiv pandemic. in this review, we highlight the application of recent advances in mycobacterial genetics in d ... | 2004 | 24981377 |
| incidence and drug susceptibility pattern of mycobacterium tuberculosis in hiv infected patien. | incidence of hiv infection in patients with tuberculosis was found out by serological method (elisa) with confirmation by western blot analysis. out of 2116 tuberculosis patients tested for hiv, 150 cases were found to be positive for hiv infection (5.73%). drug susceptibility to first line antitubercular drugs was carried out in 1378 isolates from hiv negative cases and 68 isolates from aids cases. the overall resistance pattern to one or more drugs was seen in 13.78% of isolates from hiv negat ... | 2004 | 27407606 |
| immunodiagnosis of tuberculosis: an update. | tuberculosis is still a major health problem in most developing countries and its incidence is rising in many developed countries. this resurgence has been attributed to the hiv epidemic and tb has been declared as a global health emergency by who in 1993. the diagnosis of tuberculosis mainly depends upon initial clinical suspicion and radiographic findings with subsequent bacteriological confirmation by sputum smear examination and culture. lack of sensitivity in smear examination, non specific ... | 2003 | 23105384 |
| extrapulmonary tuberculosis, epidemiology and patterns in saudi arabia. | annual incidence rates of extrapulmonary tuberculosis have been increasing over the last few years in the kingdom of saudi arabia. true rates may even be higher due to incomplete reporting. diagnosis of this condition requires high clinical suspicion, special diagnostic procedures, special staining, and culture media for acid fast bacilli. delayed diagnosis results in increasing morbidity, mortality, and cost to the health care system. particularly in areas of high endemicity of mycobacterium tu ... | 2002 | 23978962 |
| drug resistant mycobacterium tuberculosis in saudi arabia. | | 2002 | 23978929 |
| risk factors for drug-resistant mycobacterium tuberculosis in saudi arabia. | to identify rates of primary and secondary drug-resistant mycobacterium tuberculosis and their risk factors from a tertiary-care center in the kingdom of saudi arabia. | 2002 | 23978918 |
| dna amplification of a repetitive sequence - is 6110 in the early diagnosis of extra pulmonary tuberculosis. | dna amplification by polymerase chain reaction (pcr) of a repetitive sequence specific for mycobacterium tuberculosis, from clinical samples of extra pulmonary origin were evaluated. the 123 base pair fragment of the insertion element is 6110 in mycobacterium tuberculosis was amplified. a total of 50 samples were analysed by pcr and compared with culture on lowenstein-jensen medium (lj) and the clinical findings of the patient. out of the total 26 samples were positive by pcr, while only seven g ... | 2001 | 27365569 |
| detection of tubercular antibody and antigen in sera of bone and joint tuberculosis. | trichloroacetic acid (tca) solubilized and deae fractionatedmycobacterium tuberculosis h(37)ra excretory-secretory (es) antigen viz., mtb est de1 and affinity purified goat antibodies to the tca solubilized es antigen (mtb est) were explored in detecting tubercular antibody and antigen respectively in sera of bone and joint tuberculosis by indirect and sandwich elisa. out of total 36 bone & joint tuberculosis cases, tubercular antibody was detected by indirect elisa in 30 patients (sensitivity 8 ... | 2000 | 23105233 |
| identification of drug-resistantmycobacterium tuberculosis by single strand conformation polymorphism and cleavase fragment length polymorphism. | twenty isolates ofmycobacterium tuberculosis resistant to rifampicin(rif), isoniazid(inh) and streptomycin(str) were analysed by polymerase chain reaction (pcr) amplification of rpob, katg and rrs genes to evaluate comparative diagnostic significance of genetic assays. mutations were identified by single strand conformation polymorphism (sscp) and cleavase fragment length polymorphism (cflp) and were confirmed by dna sequencing. sscp of 4 rif resistant and 14 inh resistant isolates showed an ext ... | 2000 | 23105247 |
| direct diagnosis ofmycobacterium tuberculosis in blood samples of hiv infected patients by polymerase chain reaction. | we have developed a simple, economical and reproducible method for processing blood samples from hiv infected patients for diagnosis of tuberculosis. the procedure was validated on 55 samples selected for tuberculosis based on clinical criteria. 52 patients had radiological changes indicative of pulmonary tuberculosis of which only 28 were positive for afb in sputum (sensitivity 54%) and 27 for tuberculin (sensitivity 52%). 26 hiv positive patients who showed positive x-ray did not react to tube ... | 2000 | 23105245 |
| human peripheral blood lymphocytes sensitised to ppd respond to in vitro stimulation with increased expression of cd69 and cd134 activation antigens and production of th-1 type cytokines. | individuals sensitised to mycobacterium tuberculosis antigens by infection, vaccination or mantoux test generate specific memory cells. the response to in vitro restimulation with ppd is observed as the lymphoid cell proliferation and production of th-1 type cytokines. cell-mediated immune response was measured by mantoux test, lymphocyte blast transformation test, estimation of ifn-gamma production (quantiferon, elispot), and expression of cd69 and cd134 molecules on the t-helper lymphocytes (c ... | 2000 | 28008482 |
| a case report of disseminated tuberculosis: an unsuspected uterine cervical mass in a young native american woman with new-onset seizure disorder. | disseminated tuberculosis involving the uterine cervix and central nervous system is described in a 26-year-old native american female with new-onset seizures. her presenting complaint was generalized seizures with associated weight loss, chronic cough, global headache, and malaise. pelvic examination revealed an exophytic cervical mass consistent with carcinoma. laboratory results showed anemia, hypoalbuminemia, and radiodensities on chest radiography. cultures of sputum and cervix were positiv ... | 1999 | 25950560 |
| antitubercular activity of garlic (allium sativum) extract on combination with conventional antitubercular drugs in tubercular lymphadenitis. | based on our demonstration earlier that ethanol extract, water extract and a compound purified from garlic possessedin vitro antitubercular activity against drug resistant and susceptiblemycobacterium tuberculosis, we tried the effect of garlic extract in 30 patients of tubercular lymphadenitis. for ethical considerations, two groups of patients, 30 each, were given antitubercular therapy (att) consisting of isoniazid, rifampicin, ethambutol and pyrazinamide for 30 days. for the next 15 days (31 ... | 1999 | 23105197 |
| utility of gastric aspirates in screening for pulmonary tuberculosis in high risk subjects:the manitoba experience. | although gastric aspirates (ga) are one of the recommended screening procedures for asymptomatic individuals at high risk for developing tuberculosis (tb), little data exist on the utility of ga for this indication. | 1999 | 22346374 |
| mycobacterium tuberculosis h(37)ra esas-7-an excretory-secretory antigen fraction of immunodiagnostic potential in pulmonary tuberculosis. | a mycobacterial excretory-secretory protein fraction esas-7 purified by 50% ammonium sulphate precipitation followed by sds-page fractionation was evaluated by penicillinase enzyme linked immuno-sorbent assay (elisa) for its sensitivity and specificity in the diagnosis of pulmonary tuberculosis. at a "cut off" serum dilution of 600, 38 (90%) of 42 sera from bacteriologically confirmed tuberculosis cases, 15 (100%) of 15 sera from bacteriogically negative but anti tubercular therapy (att) respond ... | 1998 | 23105189 |
| genotypic detection of mutations in rifampicin resistant clinical isolates ofmycobacterium tuberculosis. | the resistance of majority ofm. tuberculosis strains to rifampicin a key drug in the tuberculosis therapy, has been cause of major alarm world-wide. such an association of strain with the drug takes a long time i.e. 2-3 months. we have modified a method for rapid detection of rifampicin resistant strains by screening them through pcr-sscp.we have identified mutations in rpo, β region of the gene encoding, β sub-unit of rna polymerase in rifampicin resistant 67 clinical isolates ofm. tuberculosis ... | 1997 | 23100909 |
| trifluoperazine and cef-allicin from garlic (allium sativum) as potential new antitubercular drugs active against drug resistantmycobacterium tuberculosis. | trifluoperazine (tfp) and a compound called cef-allicin purified from garlic (allium sativum) possess antitubercular activity against both drug susceptible and resistant clinical isolates ofmycobacterium tuberculosis. they are bactericidal in nature with multiple sites of primary action. this new use for known drug tfp was based on our observation that mycobacteria have calmodulin like protein which regulates their metabolism and a calmodulin antagonist has antitubercular activity. the minimum i ... | 1997 | 23100906 |
| mycobacterium tuberculosis 38kda antigen and its encoding gene-experience in diagnostic applications. | our experience has revealed that the detection of 38 kda antigen or antibody to the antigen in various fluids is useful in diagnosis of various mainfestations of tuberculosis. the pcr developed for 340bp sequence of its encoding gene also shows a high degree of sensitivity and specificity. thus the 38 kda antigen/antibody combination or the pcr are ideal for development of kits for diagnosis. these immunoassays to be successful, isolation of the 38 kda antigen in large quantities is essential. u ... | 1997 | 23100905 |
| drug-susceptibility pattern of mycobacterium tuberculosis among pulmonary tuberculosis patients in riyadh, saudi arabia. | to identify the pattern of drug-susceptibility of newly diagnosed pulmonary tuberculosis patients in riyadh, we conducted a study on all mycobacterium tuberculosis positive-culture patients admitted to sahari chest hospital from january 1994 to april 1995. | 1997 | 23008575 |
| detecting tuberculosis from the breath. | a device which can detect mycobacterium tuberculosis in breath is under development in america. | 1995 | 27685055 |
| immunotherapy of airborne tuberculosis in mice via the lung-specific delivery of cytokines. | the immunotherapeutic potential of interleukin-2 (il-2), tumour necrosis factor alpha (tnfα) and interferon gamma (ifn-γ) administered by aerosol was examined on mice infected with mycobacterium tuberculosis by the aerogenic route. infection of balb/c mice with 10(4) colony forming units (cfu) of m tuberculosis led to death of all mice at day 35 post infection after progressive microbial growth in the lungs. aerosolization of il-2 (100 μg per mouse) did not promote an increase in resistance to t ... | 1993 | 22346418 |
| tuberculosis involving the oral cavity. | the oral cavity is a rare site for extrapulmonary tuberculosis. a case is reported of a young woman with dysphagia and oral ulceration. the original mucosal biopsy was negative on smear for acid-fast bacilli, and the patient subsequently developed pulmonary symptoms. a diagnosis of mycobacterium tuberculosis was ultimately made on open lung biopsy. complete resolution of both mouth lesion and chest involvement occurred with standard antituberculous therapy. | 1993 | 22346412 |
| 9-amino-2,3-dimethoxy-6-nitroacridine 10-oxides. | | 1962 | 14056448 |
| [cultivation of mycobacterium tuberculosis. comparison of isolation with sodium hydroxide and trisodium phosphate]. | | 2014 | 24546670 |
| [comparison of the tissue culture method with 4 conventional methods for the evaluation of the virulence of tubercle bacilli]. | | 1960 | 24545395 |
| the relative efficacy of culture media for the isolation of mycobacterium tuberculosis from clinical material. | | 1959 | 24546126 |
| the tuberculostatic activity of intermediate compounds of chloramphenicol. | | 1959 | 24545324 |
| [studies on the effect of mycerin on mycobacterium tuberculosis]. | | 2014 | 24545072 |
| [problem of resistance and sensitivity to streptomycin of mycobacterium tuberculosis]. | | 2014 | 24544828 |
| tuberculostatic activity of certain 2-phenylbenzothiazole derivatives. | | 1958 | 24544650 |
| [incidence of strains of mycobacterium tuberculosis resistant to chemotherapeutic agents in patients with recently discovered tuberculosis]. | | 2014 | 24544788 |
| the in vitro effect of na-pas and na-b-pas on mycobacterium tuberculosis and a comparison of dubos and ats media for the study. | | 1957 | 24544328 |
| [comparison of five culture media for the primary isolation of mycobacterium tuberculosis]. | | 2014 | 24544782 |
| [research on the vitro tuberculostatic activity of cyanacetic acid hydrazide in comparison with isoniazid]. | | 2014 | 24544781 |
| [75th anniversary of the discovery of the tubercle bacillus]. | | 2014 | 24544995 |
| [carbon-agar, blood-agar and loewenstein-jensen-holm media in culture of mycobacterium tuberculosis]. | | 2014 | 24544471 |
| [fate of the tuberculosis bacillus in the organism; a review]. | | 2014 | 24544310 |
| the inhibitory effect of p-aminosalicylic acid in serum against mycobacterium tuberculosis. | | 1955 | 24543815 |
| preliminary note on the isolation of an antituberculous substance from a streptomyces strain. | | 1955 | 24543813 |
| in vitro and in vivo studies with combinations of subeffective doses of antibiotics on streptomycin-resistant tubercle bacilli. | | 1955 | 24543811 |
| the effect of inoculum on the tuberculostatic activity. | | 1955 | 24543768 |
| antituberculous substances from aspergillus proliferans and a. variecolor. | | 1955 | 24543706 |
| effects of cycloserine on mycobacterium tuberculosis in vitro. | | 1955 | 24543466 |
| [clinicopathological significance of the determination of viable tubercle bacilli in resected lesions]. | | 2014 | 24543634 |
| the anti-tuberculous activity of some derivatives of p-aminosalicylic acid, nicotinic acid, and isonicotinic acid. | | 1955 | 24543399 |
| [blood agar medium in the culture of mycobacterium tuberculosis]. | | 2014 | 24543547 |
| combined action of streptomycin and chloramphenicol with plant antibiotics against tubercle bacilli. i. streptomycin and chloramphenicol with cepharanthine. ii. streptomycin and allicin. | | 1955 | 24543344 |
| a short note on antitubercular substance from occium sanctum. | | 1955 | 24543343 |
| in vitro study of antitubercular substances from allium species. i. allium schoenoprasum. ii. allium cepa. | | 1955 | 24543342 |
| [comparison of the activity of isoniazid and isoniazid methanesulfonate. ii. in guinea pigs experimentally infected with mycobacterium tuberculosis (h37 rv)]. | | 2015 | 24543417 |
| in vitro activity of n-isonicotinoyl-n'-(2,2-dimethyl-3-hydroxypropylidene) hydrazine (pivalizid) against mycobacterium tuberculosis. | | 1954 | 24543181 |
| p-aminosalicylic acid hydrazide in vitro activity against mycobacterium tuberculosis. | | 1954 | 24543180 |
| in vitro activity of n-isonicotinoyl-n'-(salicylidene) hydrazine (salizid) against mycobacterium tuberculosis. | | 1954 | 24543179 |
| [comparative studies on isoniazid and calcium methanesulfonate of isonicotinic acid hydrazide (erbazid). i. experiments in rats infected with massive doses of mycobacterium tuberculosis]. | | 2015 | 24543194 |
| plant substances active against mycobacterium tuberculosis. | | 1954 | 24543026 |
| the effect of bovine plasma on the tuberculostatic activity of gamma-pheroxypropylamine. | | 1954 | 24543025 |
| elaiomycin, a new tuberculostatic antibiotic; biologic studies. | | 1954 | 24542957 |
| tuberculostatic properties of some diphenylamines. | | 1954 | 24542891 |
| inhibition of mycobacterial esterases by polymyxin b. | | 1954 | 24542869 |
| relations between the chemical structure and the activity of some inhibitors of mycobacterium tuberculosis. | | 1953 | 24542581 |
| isolation of a new antibiotic from streptomyces fasiculatus nov.sp. | | 1953 | 24542543 |
| antibacterial substances in seed plants active against tubercle bacilli. ii. the antibacterial principles of primula malacoides and buxus sempervirens. | | 1953 | 24542685 |