| p40 and p90 from mpn142 are targets of multiple processing events on the surface of mycoplasma pneumoniae. | mycoplasma pneumoniae is a significant cause of community acquired pneumonia globally. despite having a genome less than 1 mb in size, m. pneumoniae presents a structurally sophisticated attachment organelle that (i) provides cell polarity, (ii) directs adherence to receptors presented on respiratory epithelium, and (iii) plays a major role in cell motility. the major adhesins, p1 (mpn141) and p30 (mpn453), are localised to the tip of the attachment organelle by the surface accessible cleavage f ... | 2015 | 28248283 |
| extrapulmonary involvement associated with mycoplasma pneumoniae infection. | mycoplasma pneumoniae infection usually presents with upper and lower respiratory tract infection. extrapulmonary involvement is not uncommon, however. we report two cases of predominantly extrapulmonary manifestations of mycoplasma pneumoniae infection without significant pulmonary involvement. both cases were diagnosed by serology. these cases illustrate the diversity of clinical presentations of mycoplasma pneumoniae infection. clinicians should maintain a high index of suspicion. | 2015 | 26634375 |
| systematic structural analyses of attachment organelle in mycoplasma pneumoniae. | mycoplasma pneumoniae, a human pathogenic bacterium, glides on host cell surfaces by a unique and unknown mechanism. it forms an attachment organelle at a cell pole as a membrane protrusion composed of surface and internal structures, with a highly organized architecture. in the present study, we succeeded in isolating the internal structure of the organelle by sucrose-gradient centrifugation. the negative-staining electron microscopy clarified the details and dimensions of the internal structur ... | 2015 | 26633540 |
| [pathogenic factors of mycoplasma]. | mycoplasmas are smallest organisms capable of self-replication and cause various diseases in human. especially, mycoplasma pneumoniae is known as an etiological agent of pneumonia. from 2010 to 2012, epidemics of m. pneumoniae infections were reported worldwide (e.g., in france, israel, and japan). in the diseases caused by mycoplasmas, strong inflammatory responses induced by mycoplasmas have been thought to be important. however, mycoplasmas lack of cell wall and do not possess inflammation-in ... | 2015 | 26632216 |
| effects of bacterial and viral co-infections of mycoplasma pneumoniae pneumonia in children: analysis report from beijing children's hospital between 2010 and 2014. | the objective of this study was to describe the rates and impact of bacterial and viral co-infections of hospitalized children with mycoplasma pneumoniae. the clinical characteristics, hospital expenses, and differences between single and co-infection mpp were explored. this study included 5,009 children from 2010 to 2014. infections with various pathogens were identified by the following tests: positive specimens' culture, direct immunofluorescent antigen test for viruses, mycoplasma or chlamyd ... | 2015 | 26629061 |
| olson et al. outbreak of mycoplasma pneumoniae-associated stevens johnson syndrome. pediatrics. 2015;136(2):e386-394. | | 2015 | 26628717 |
| extra-pulmonary manifestations associated with mycoplasma pneumoniae pneumonia in adults. | | 2016 | 26621759 |
| sp-d, kl-6, and hti-56 levels in children with mycoplasma pneumoniae pneumonia. | the study was aimed to evaluate the potential biomarkers from pulmonary surfactant protein d (sp-d), krebs von den lungen-6 (kl-6), and 56-kd a human type i protein (hti-56) in serum and bronchoalveolar lavage fluid samples of children with mycoplasma pneumoniae pneumonia. this retrospective study, self-controlled study enrolled 34 chinese children with m. pneumoniae pneumonia. the levels of sp-d, kl-6, and hti-56 in bronchoalveolar lavage fluid samples were assessed and compared between patient ... | 2015 | 26617840 |
| correction notice for tnf-r on mast cells regulate airway responses to mycoplasma pneumoniae. | | 2016 | 26611673 |
| ameliorative effects of qingfei tongluo formula on experimental mycoplasmal pneumonia in mice. | mycoplasma pneumoniae pneumonia (mpp) is a common disease in children. qingfei tongluo formula (qtf) has been used for the treatment of mpp clinically, but the chemical constituents and mechanism involved remain unclear. this study aimed to analyze the main chemical constituents and to explore the possible mechanism of action associated with qtf treatment of mpp. liquid chromatography-mass spectrometry was employed to identify the compounds contained in the qtf extract. a balb/c mouse model of m ... | 2016 | 26590157 |
| incident asthma and mycoplasma pneumoniae: a nationwide cohort study. | previous studies investigating the relationship between mycoplasma pneumoniae and incident asthma in the general population have been inconclusive. | 2016 | 26586037 |
| [pathogen detection of 1 613 cases of hospitalized children with community acquired pneumonia]. | to investigate the distribution of pathogens of children with community acquired pneumonia (cap) from the chongqing area. | 2015 | 26575877 |
| [early identification of refractory mycoplasma pneumoniae pneumonia in children]. | to investigate the clinical indicators for early identification of refractory mycoplasma pneumoniae pneumonia (rmpp) in children. | 2015 | 26575876 |
| [a study on the clinical course and antimicrobial susceptibility of mycoplasma pneumoniae in a community hospital]. | recently, reports of macrolide-resistant strains of mycoplasma pneumoniae have been increasing. we examined the antimicrobial susceptibility and clinical significance in patients with m. pneumoniae. seventy patients in whom m. pneumoniae was detected from 2008 to 2012 were included in the study, and compared with patients between 2003 and 2006. there were no macrolide-resistant strains detected in the 38 strains from 2003 to 2006, but from 2008 to 2012, out of the 70 strains 46 (65.7%) were posi ... | 2015 | 26554221 |
| [evaluation of a rapid antigen detection kit targeting l7/l12 ribosomal protein for mycoplasma pneumoniae]. | we evaluated the usefulness of a rapid antigen detection assay for l7/l12 ribosomal protein (ribotest mycoplasma; asahi kasei pharma) for diagnosis of mycoplasma pneumoniae (m. pneumoniae) infection. nasopharyngeal swabs were obtained from patients with pneumonia and/or bronchitis; real-time pcr and the l 7/l12 antigen assays were performed with each sample. serum was also taken from each patient, and the particle agglutination (pa) method was used to detect anti-m. pneumoniae antibody in these ... | 2015 | 26552132 |
| [gene mutations associated with macrolide-resistance and p1 gene typing of mycoplasma pneumoniae isolated in yamagata, japan, between 2004 and 2013]. | to clarify the epidemiologic features of mycoplasma pneumoniae, we examined 358 m. pneumoniae strains isolated between 2004 and 2013 in yamagata, japan. analysis of macrolide-resistance-associated 23s ribosomal rna (rrna) domain v mutations revealed 6 kinds of mutants (81 a2063g, 43 a2063t, 1 a2063c, 1 a2064c, 4 c2617g and 1 c2617 mutation). there were only two mutants before 2009, but mutants a2063t and a2063g increased in 2009 and from 2010, respectively. the annual ratio of mutants varied fro ... | 2015 | 26548292 |
| a case of a methicillin-resistant staphylococcus aureus retropharyngeal abscess with mediastinal extension in an 11-month-old girl. | we present the case of an 11-month-old girl with mycoplasma pneumoniae-associated pneumonia who was subsequently diagnosed with a methicillin-resistant staphylococcus aureus retropharyngeal abscess with mediastinal extension. | 2016 | 26541226 |
| prevalence, genotyping and macrolide resistance of mycoplasma pneumoniae among isolates of patients with respiratory tract infections, central slovenia, 2006 to 2014. | in this retrospective study we employed real-time polymerase chain reaction (pcr) to analyse the occurrence of mycoplasma pneumoniae among upper and lower respiratory tract infections (rti) in the central region of slovenia between january 2006 and december 2014. we also used a culture and pyrosequencing approach to genotype strains and infer their potential macrolide resistance. of a total 9,431 tested samples from in- and out-patient with rti, 1,255 (13%) were found to be positive by m. pneumo ... | 2015 | 26536357 |
| molecular typing of mycoplasma pneumoniae: where do we stand? | | 2015 | 26517043 |
| [severe haemolysis caused by mycoplasma pneumoniae]. | mycoplasma pneumoniae is naturally resistant to betalactamase antibiotics but is sensitive to macrolides. occasionally, infections with m. pneumoniae can lead to severe anaemia due to its ability to cause haemolysis when cold agglutination occurs. increasing bacterial resistance to macrolid antibiotics is a growing concern worldwide. we present two cases where infection with m. pneumoniae caused severe haemolysis, one of which was macrolide-resistant. | 2015 | 26509456 |
| [distribution of pathogenic microorganisms and its relationship with clinical features in children with community-acquired pneumonia]. | to study the distribution of pathogenic microorganisms in different genders, age groups and seasons in children with community-acquired pneumonia (cap) and the relationship between the distribution of pathogenic microorganisms and clinical features. | 2015 | 26483223 |
| acute necrotizing pancreatitis associated with mycoplasma pneumoniae infection in a child. | mycoplasma pneumoniae is responsible for approximately 20% to 30% of community-acquired pneumonia, and is well known for its diverse extrapulmonary manifestations. however, acute necrotizing pancreatits is an extremely rare extrapulmonary manifestation of m. pneumoniae infection. a 6-year-old girl was admitted due to abdominal pain, vomiting, fever, and confused mentality. acute necrotizing pancreatitis was diagnosed according to symptoms, laboratory test results, and abdominal computed tomograp ... | 2015 | 26473143 |
| in vitro subminimum inhibitory concentrations of macrolide antibiotics induce macrolide resistance in mycoplasma pneumoniae. | this study aims to investigate the inducing effect of subminimum inhibitory concentrations of macrolide antibiotics on mycoplasma pneumoniae (m. pneumoniae) resistance to drugs. | 2017 | 26435649 |
| acute generalized exanthematous pustulosis induced by mycoplasma pneumoniae infection. | | 2016 | 26427049 |
| in silico approaches for the identification of virulence candidates amongst hypothetical proteins of mycoplasma pneumoniae 309. | mycoplasma pneumoniae type 2a strain 309 is a simplest known bacterium and is the primary cause of community acquired pneumonia in the children. it mainly causes severe atypical pneumonia as well as several other non-pulmonary manifestations such as neurological, hepatic, hemolytic anemia, cardiac diseases and polyarthritis. the size of m. pneumoniae genome (accession number: nc_016807.1) is relatively smaller as compared to other bacteria and contains 707 functional proteins, in which 204 are c ... | 2015 | 26414949 |
| the determinant of periodicity in mycoplasma pneumoniae incidence: an insight from mathematical modelling. | until the early 1990 s, incidences of mycoplasma pneumoniae (mp) infection showed three to five year epidemic cycles in multiple countries, however, the mechanism for the mp epidemic cycle has not been understood. here, we investigate the determinant of periodicity in mp incidence by employing a mathematical model describing mp transmission dynamics. three candidates for the determinant of periodicity were evaluated: school-term forcing, minor variance in the duration of immunity, and epidemiolo ... | 2015 | 26412506 |
| [clinical significance of mp-dna from endotracheal aspirates in diagnosis of mycoplasma pneumoniae pneumonia in children]. | to compare the detection rates of mycoplasma pneumoniae (mp) from nasopharyngeal aspirates (npa) and bronchoalveolar lavage fluid (balf) in children with pneumonia. | 2015 | 26412174 |
| comparison of molecular characteristics of mycoplasma pneumoniae specimens collected from the united states and china. | mycoplasma pneumoniae-positive clinical specimens obtained from the united states and china during the same period were studied for their molecular characteristics. we found much more diverse genotypes and a lower prevalence of macrolide resistance in the u.s. specimens. data from the study also showed an association of the resistance with certain genotypes. | 2015 | 26400785 |
| overview of antimicrobial options for mycoplasma pneumoniae pneumonia: focus on macrolide resistance. | community-acquired pneumonia (cap) is a common infectious disease affecting children and adults of any age. mycoplasma pneumoniae has emerged as leading causative agent of cap in some region, and the abrupt increasing resistance to macrolide that widely used for management of m. pneumoniae has reached to the level that it often leads to treatment failures. | 2015 | 26365811 |
| correction: sp-a preserves airway homeostasis during mycoplasma pneumoniae infection in mice. | | 2015 | 26342104 |
| emergence of macrolide-resistant mycoplasma pneumoniae in hong kong is linked to increasing macrolide resistance in multilocus variable-number tandem-repeat analysis type 4-5-7-2. | macrolide-resistant mycoplasma pneumoniae (mrmp) is rapidly emerging in asia, but information on the temporal relationship between the increase in macrolide resistance and changes in strain types is scarce. between 2011 and 2014, m. pneumoniae infection was diagnosed by pcr as part of routine care in a health care region in hong kong. testing was initiated by clinicians, mainly in patients with suspected m. pneumoniae pneumonia. specimens positive for m. pneumoniae were retrospectively investiga ... | 2015 | 26338857 |
| comparative "-omics" in mycoplasma pneumoniae clinical isolates reveals key virulence factors. | the human respiratory tract pathogen m. pneumoniae is one of the best characterized minimal bacterium. until now, two main groups of clinical isolates of this bacterium have been described (types 1 and 2), differing in the sequence of the p1 adhesin gene. here, we have sequenced the genomes of 23 clinical isolates of m. pneumoniae. studying snps, non-synonymous mutations, indels and genome rearrangements of these 23 strains and 4 previously sequenced ones, has revealed new subclasses in the two ... | 2015 | 26335586 |
| new insights in the outbreak pattern of mycoplasma pneumoniae. | since a well-documented incidence peak in 2011/12 in european countries, infections due to the cell wall-less bacterium mycoplasma pneumoniae have gained the increased attention of clinicians, microbiologists and health authorities. despite the mild or asymptomatic clinical course of most m. pneumoniae infections, the microorganism is responsible for severe interstitial pneumonia and extra-pulmonary complications. here, we report the time-dependence of 5545 notified cases of laboratory-confirmed ... | 2015 | 26319941 |
| diagnostic delay and amniotic membrane transplantation in a child with atypical stevens-johnson syndrome. | a 4-year-old boy presented with a 6-day history of severe non-limbic-sparing conjunctivitis. atypical stevens-johnson syndrome with a possible cause of mycoplasma pneumoniae was suspected as the precipitant of the clinical symptoms. the patient recovered with amniotic membrane transplantation and intravenous immunoglobulin therapy despite an initial delay in diagnosis. | 2015 | 26301401 |
| utility of serum ferritin and lactate dehydrogenase as surrogate markers for steroid therapy for mycoplasma pneumoniae pneumonia. | patients with severe mycoplasma pneumonia having very high serum interleukin-18 levels may require systemic corticosteroid treatment. however, we know of no laboratory markers that have been identified to assess the precise severity of mycoplasma pneumoniae pneumonia. thus, we investigated the usefulness of four clinical laboratory tests as severity indicators and surrogate markers for initiation of steroid therapy in these patients. | 2015 | 26298038 |
| lipschütz ulcers: should we rethink this? an analysis of 33 cases. | to describe the presentation and characteristics of patients with lipschütz ulcers (lu) and to evaluate the role of a standard protocol in the aetiological diagnosis. | 2016 | 26297242 |
| molecular detection and characterization of mycoplasma pneumoniae among patients hospitalized with community-acquired pneumonia in the united states. | background. mycoplasma pneumoniae is a common cause of community-acquired pneumonia (cap). the molecular characteristics of m pneumoniae detected in patients hospitalized with cap in the united states are poorly described. methods. we performed molecular characterization of m pneumoniae in nasopharyngeal/oropharyngeal swabs from children and adults hospitalized with cap in the centers for disease control and prevention etiology of pneumonia in the community (epic) study, including p1 typing, m ... | 2015 | 26284257 |
| comparative genome analysis of mycoplasma pneumoniae. | mycoplasma pneumoniae is a common pathogen that causes upper and lower respiratory tract infections in people of all ages, responsible for up to 40% of community-acquired pneumonias. it also causes a wide array of extrapulmonary infections and autoimmune phenomena. phylogenetic studies of the organism have been generally restricted to specific genes or regions of the genome, because whole genome sequencing has been completed for only 4 strains. to better understand the physiology and pathogenici ... | 2015 | 26275904 |
| acute postinfectious glomerulonephritis with a large number of crescents caused by mycoplasma pneumoniae. | mycoplasma pneumoniae-induced acute postinfectious glomerulonephritis has various pathological changes and relatively poor prognosis. it often occurs in children, barely in adults. currently, no clear treatment guidelines have been established for its treatment using glucocorticoid and immunosuppressive. in this study, we report an adult who admitted to our hospital due to fever and gross hematuria. the patient presented with nephritic syndrome and renal failure and confirmed to have m. pneumoni ... | 2015 | 26275270 |
| international mycoplasma pneumoniae typing study: interpretation of m. pneumoniae multilocus variable-number tandem-repeat analysis. | typing of mycoplasma pneumoniae by multiple-locus variable-number tandem repeat analysis (mlva) is increasingly in use. however, no specific internationally agreed guidance is available. thirty m. pneumoniae dna samples including serial dilutions of a type strain were sent to six international laboratories to perform mlva and results were compared. good correlation was observed, indicating that this methodology can be robustly performed in multiple sites. however, differences due to interpretati ... | 2015 | 26236493 |
| hepatitis associated with mycoplasma pneumoniae infection in korean children: a prospective study. | mycoplasma pneumoniae (mp) infection is a major cause of respiratory infection in school-aged children. extrapulmonary manifestations of mp infection are common, but liver involvement has been rarely reported. the aim of this study was to determine the clinical characteristics of mp-associated hepatitis. | 2015 | 26213549 |
| [a case of acute disseminated encephalomyelitis (adem) with an anti-galactocerebroside antibody]. | acute disseminated encephalomyelitis (adem) with an anti-galactocerebroside antibody is very rare. we report a case of 82-year-old man with adem associated with anti-galactocerebroside antibody in serum. he was admitted to our hospital after developing disturbed consciousness and respiratory failure. a cerebrospinal fluid examination disclosed an albuminocytologic dissociation and elevation of myelin basic protein. magnetic resonance images revealed lesions in the medulla oblongata, pons, midbra ... | 2015 | 26211664 |
| molecular epidemiology of mycoplasma pneumoniae: genotyping using single nucleotide polymorphisms and snapshot technology. | molecular typing of mycoplasma pneumoniae is an important tool for identifying grouped cases and investigating outbreaks. in the present study, we developed a new genotyping method based on single nucleotide polymorphisms (snps) selected from the whole-genome sequencing of eight m. pneumoniae strains, using the snapshot minisequencing assay. eight snps, localized in housekeeping genes, predicted lipoproteins, and adhesin p1 genes were selected for genotyping. these snps were evaluated on 140 m. ... | 2015 | 26202117 |
| [mycoplasma pneumoniae-induced meningoencephalitis]. | in clinical practice, secondary infections of the central nervous system (cns) represent rare yet severe complications of their respective primary infections. in this case report, we describe a 22-year-old patient with a medical history of asthma bronchiale, who developed significant neurological deficits after a respiratory infection. the neurological symptoms progressed despite antibiotic therapy with vancomycin, ampicillin and ceftriaxone. the patient's cerebrospinal fluid and a cranial magne ... | 2015 | 26200044 |
| macrolide-resistant mycoplasma pneumoniae, united states. | macrolide-resistant mycoplasma pneumoniae (mrmp) is highly prevalent in asia and is now being reported from europe. few data on mrmp are available in the united states. using genotypic and phenotypic methods, we detected high-level mrmp in 13.2% of 91 m. pneumoniae--positive specimens from 6 us locations. | 2015 | 26196107 |
| changes in levels of il-9, il-17, ifn-γ, dendritic cell numbers and tlr expression in peripheral blood in asthmatic children with mycoplasma pneumoniae infection. | mycoplasma pneumoniae (mp) infection in children with asthma resulted in a more severe allergic state compared with a non-mp infected group. the infection rate of children with asthma was higher than that of the other groups, suggesting that being asthmatic may be a predisposing factor for mp infection and that the infection itself is an important co-factor in the disease progression of asthma. the number of dendritic cells (dcs) and the expression of tlr2 and tlr4 were compared in 22 asthmatic ... | 2015 | 26191227 |
| reply to: "diagnosing mycoplasma pneumoniae-induced rash and mucositis (mirm) in the emergency room". | | 2015 | 26184003 |
| diagnosing mycoplasma pneumoniae-induced rash and mucositis (mirm) in the emergency room. | | 2015 | 26184002 |
| activation of inflammasomes in dendritic cells and macrophages by mycoplasma salivarium. | interleukin-1β (il-1β) plays crucial roles in the pathogenesis of periodontal disease. it is produced after the processing of pro-il-1β by caspase-1, which is activated by the inflammasome-a multiprotein complex comprising nucleotide-binding domain leucine-rich repeat-containing receptor (nlr), the adaptor protein apoptosis-associated speck-like protein containing a caspase-recruitment domain (asc), and procaspase-1. mycoplasma salivarium preferentially inhabits the gingival sulcus and the incid ... | 2016 | 26177301 |
| lung abscess caused by mycoplasma pneumoniae. | a 10-year-old boy with west syndrome was referred to hospital because of high fever and cough. chest x-ray and computed tomography showed consolidation with an abscess in the right upper lobe. laboratory data indicated cytokine storm. various antibacterial agents and additional corticosteroid were unable to control the hypercytokinemia, which was suppressed after cyclosporine a was started. the lung abscess remained, however, and right upper lobectomy was performed. culture from the abscess show ... | 2015 | 26177124 |
| significance of lipopolysaccharide detection in children with pulmonary infections. | the present study aimed to observe the alterations of lipopolysaccharide (lps) and some other laboratory indexes in children suffering from pulmonary infections, and to investigate the condition of gram-negative bacterial infection. | 2015 | 26166651 |
| regional differences in prevalence of macrolide resistance among pediatric mycoplasma pneumoniae infections in hokkaido, japan. | recently, macrolide-resistant (mr) mycoplasma pneumonia appeared, and prevalence of macrolide resistance among m. pneumoniae infections varies by country. however, reports on regional differences in the prevalence of mr m. pneumonia within a country are scarce. in this study, 617 nasopharyngeal swab samples were collected from 617 pediatric patients, and dna of m. pneumoniae was identified in 95 samples. in 51 of the 95 m. pneumonia positive samples, we detected the presence of mutation a2063g m ... | 2016 | 26166502 |
| clinical features of post-infectious bronchiolitis obliterans in children undergoing long-term azithromycin treatment. | the aim of the present study was to outline any predisposing factors and clinical and radiological features of post-infectious bronchiolitis obliterans (pibo) in pediatric patients, and to determine the effect of long-term azithromycin treatment on these factors. in total, 16 cases of children with pibo were retrospectively reviewed. adenovirus and mycoplasma pneumoniae were the most common etiological agents (12/16) in the children with pibo. the patients presented with persistent dyspnea, a ch ... | 2015 | 26136991 |
| epidemiological comparison of three mycoplasma pneumoniae pneumonia epidemics in a single hospital over 10 years. | mycoplasma pneumoniae (mp) pneumonia epidemics have occurred in 3- to 4-year cycles in korea. we evaluated the epidemiologic characteristics of mp pneumonia in daejeon, korea, from 2003 to 2012. | 2015 | 26124847 |
| specificity and strain-typing capabilities of nanorod array-surface enhanced raman spectroscopy for mycoplasma pneumoniae detection. | mycoplasma pneumoniae is a cell wall-less bacterial pathogen of the human respiratory tract that accounts for > 20% of all community-acquired pneumonia (cap). at present the most effective means for detection and strain-typing is quantitative polymerase chain reaction (qpcr), which can exhibit excellent sensitivity and specificity but requires separate tests for detection and genotyping, lacks standardization between available tests and between labs, and has limited practicality for widespread, ... | 2015 | 26121242 |
| severe childhood guillain-barré syndrome associated with mycoplasma pneumoniae infection: a case series. | we report seven children with recent mycoplasma pneumoniae infection and severe guillain-barré syndrome (gbs) that presented to two european medical centres from 1992 to 2012. severe gbs was defined as the occurrence of respiratory failure, central nervous system (cns) involvement, or death. five children had gbs, one bickerstaff brain stem encephalitis (bbe), and one acute-onset chronic inflammatory demyelinating polyneuropathy (a-cidp). the five patients with severe gbs were derived from an or ... | 2015 | 26115201 |
| neurological complications of pcr-proven m. pneumoniae infections in children: prodromal illness duration may reflect pathogenetic mechanism. | the spectrum of neurologic disease attributable to mycoplasma pneumoniae in children is incompletely understood in part because of limitations of microbiologic diagnostic methods. our objective was to characterize the neurologic complications of m. pneumoniae in children using stringent diagnostic criteria. | 2015 | 26084846 |
| synergistic effects of mycoplasma pneumoniae infection and drug reaction on the development of atypical stevens-johnson syndrome in adults. | | 2016 | 26084288 |
| [advantages and disadvantages of microbiological methods used in the diagnosis of mycoplasmapneumoniae infections in selected clinical situation]. | mycoplasma pneumoniae is one of the most common causes of community-acquired pneumonia in children and adults. correct and rapid laboratory diagnosis of m pneumoniae infections is important to introduce appropriate antibiotic treatment. diagnosis for m. pneumoniae usually relies on serological tests and/or molecular investigations. both methods have some advantages but also limitations. this paper presents advantages and disadvantages of microbiological methods used in m. pneumoniae infection an ... | 2015 | 26084074 |
| [coexistence of pulmonary hydatid cyst and mycoplasma pneumoniae pnömonia in a child]. | hydatid cyst is a zoonotic disease and endemic in turkey. the disease can involve any organ. the most common involved organ is lung in childhood. hydatid cyst of lung may be asymptomatic or may be sometimes ruptured or infected. secondary bacterial infections associated with the hydatid cyst are well known. a previously not reported pediatric case of hydatid cyst with mycoplasma pneumoniae pneumonia is described in this report. it is emphasized that m. pneumoniae should be kept in mind as a caus ... | 2015 | 26081892 |
| eeg extreme delta brush: an ictal pattern in patients with anti-nmda receptor encephalitis. | the anti-nmda receptor (nmdar) encephalitis-associated syndrome includes neuropsychiatric symptoms, impaired consciousness, seizures, autonomic instability, and hypoventilation. the electroencephalographic (eeg) activity throughout the course of the disease has still not been well documented. we reviewed electroclinical data of patients with nmdar encephalitis to characterize their eeg and its clinical correlation. | 2015 | 26071995 |
| hemorrhagic encephalitis caused by mycoplasma pneumoniae in an 11-year-old boy: a rare case report. | | 2015 | 26068367 |
| unusual eruptions associated with mycoplasma pneumoniae respiratory infections: review of the literature. | maculopapular or urticarial eruptions and erythema multiforme sometimes occur in patients affected with mycoplasma pneumoniae respiratory infections. further eruptions have also been reported. | 2015 | 26067570 |
| changes of serum tnf-α, il-5 and ige levels in the patients of mycoplasma pneumonia infection with or without bronchial asthma. | this study aimed to investigate the changes of serum levels of tnf-α, il-5 and ige in mycoplasma pneumonia (mp) infection patients with or without bronchial asthma and explore its clinical importance. | 2015 | 26064291 |
| lactate dehydrogenase as a biomarker for prediction of refractory mycoplasma pneumoniae pneumonia in children. | corticosteroids have been used for refractory mycoplasma pneumoniae pneumonia and have beneficial effects. the aim of this study was to identify the biomarkers for predicting refractory m. pneumoniae pneumonia in a timely fashion to initiate steroid therapy. | 2015 | 26060318 |
| mycoplasma pneumoniae infection in adults with acute and chronic urticaria. | | 2015 | 26057513 |
| [neurological symptoms due to mycoplasma pneumoniae infection in nine children]. | mycoplasma pneumoniae infection is common in children. extrapulmonary symptoms usually reveal as neurological symptoms, mainly as encephalitis with significant morbidity and mortality. various other neurological presentations have also been reported. we describe a cohort of nine children with neurological manifestations due to m. pneumoniae infection, including five cases of encephalitis, one of polyradiculoneuritis, one of ophthalmoplegia, one of optic neuritis, and one of myositis. progression ... | 2015 | 26047743 |
| mycoplasma pneumoniae pneumonia associated with methemoglobinemia and anemia: an overlooked association? | we report a case of acute methemoglobinemia and anemia in a patient with mycoplasma pneumoniae pneumonia. we suggest that m. pneumoniae secretes a putative protein that can induce methemoglobin in red blood cells. thus, mycoplasma pneumoniae may induce methemoglobinemia in patients who have low oxygen saturation and anemia. | 2015 | 26034771 |
| [prognostic judgment of children with mycoplasma pneumoniae pneumonia associated with airway mucous plug formation]. | to investigate the clinical characteristics and treatment defects in slow-to-recover children with mycoplasma pneumoniae pneumonia (mpp) associated with airway mucous plug formation, and to provide a basis for prognostic judgment and therapeutic guidance. | 2015 | 26014701 |
| pathogenesis and association of mycoplasma pneumoniae infection with cardiac and hepatic damage. | the aim of this study was to investigate the pathogenesis of mycoplasma pneumoniae (mp) infection and its association with cardiac and hepatic damage. between march 2013 and march 2014, 59 children with mp pneumonia (mpp) and 30 healthy children were enrolled. serum titers of tlr4, t cell immunoglobulin and mucin-domain (tim) 3, il-10, tnf-α, and ifn-γ were measured both in children with mpp and healthy children. additionally, mp-specific antibody titer and creatine kinase-mb (ck-mb), and alanin ... | 2015 | 26011190 |
| enzymatic amplification-free nucleic acid hybridisation sensing on nanostructured thick-film electrodes by using covalently attached methylene blue. | amplification-free (referring to enzymatic amplification step) detection methodologies are increasing in biosensor development due to the need of faster and simpler protocols. however, for maintaining sensitivity without this step, highly detectable molecules or very sensitive detection techniques are required. the nanostructuration of transducer surfaces with carbon nanotubes (cnts), gold nanoparticles (aunps) or both in nanohybrid configurations has been employed in this work for dna hybridisa ... | 2015 | 26003686 |
| cutaneous vasculitis and renal involvement in mycoplasma pneumoniae infection. | | 2015 | 25995672 |
| subunits of the pyruvate dehydrogenase cluster of mycoplasma pneumoniae are surface-displayed proteins that bind and activate human plasminogen. | the dual role of glycolytic enzymes in cytosol-located metabolic processes and in cell surface-mediated functions with an influence on virulence is described for various micro-organisms. cell wall-less bacteria of the class mollicutes including the common human pathogen mycoplasma pneumoniae possess a reduced genome limiting the repertoire of virulence factors and metabolic pathways. after the initial contact of bacteria with cells of the respiratory epithelium via a specialized complex of adhes ... | 2015 | 25978044 |
| reversible bilateral striatal lesions following mycoplasma pneumoniae infection associated with elevated levels of interleukins 6 and 8. | reversible bilateral striatal necrosis associated with mycoplasma pneumoniae (m. pneumoniae) infection is a rare neurological disease. the exact pathogenic mechanism remains unknown. | 2016 | 25972305 |
| epidemiology and clinical profiles of mycoplasma pneumoniae infection in hospitalized infants younger than one year. | mycoplasma pneumoniae (m. pneumoniae) is an important pathogen of community-acquired pneumonia in children, but the epidemiology and clinical features of m. pneumoniae infection in infants are reported in only a few studies. this study aims to evaluate possible age-related differences in the presenting clinical features in infants with m. pneumoniae infection. | 2015 | 25957828 |
| genetic variation in sp-a2 leads to differential binding to mycoplasma pneumoniae membranes and regulation of host responses. | mycoplasma pneumoniae is an extracellular pathogen that colonizes mucosal surfaces of the respiratory tract and is associated with asthma exacerbations. previous reports demonstrate that surfactant protein-a (sp-a) binds live m. pneumoniae and mycoplasma membrane fractions (mmf) with high affinity. humans express a repertoire of single-amino acid genetic variants of sp-a that may be associated with lung disease, and our findings demonstrate that allelic differences in sp-a2 (gln223lys) affect th ... | 2015 | 25957169 |
| 50 years ago in the journal of pediatrics: mycoplasma pneumoniae (eaton atypical pneumonia agent) in children's respiratory infections. | | 2015 | 25919730 |
| [determination of th9 cells and il-9 in children with mycoplasma pneumoniae infection]. | to investigate the clinical significance of t helper type 9 (th9) cells and interleukin-9 (il-9) in children suffering from mycoplasma pneumoniae (mp) infection. | 2015 | 25919545 |
| catalase enhances growth and biofilm production of mycoplasma pneumoniae. | mycoplasma pneumoniae causes chronic respiratory disease in humans. factors thought to be important for colonization include the ability of the mycoplasma to form a biofilm on epithelial surfaces and the production of hydrogen peroxide to damage host tissue. almost all of the mycoplasmas, including m. pneumoniae, lack superoxide dismutase and catalase and a balance should exist between peroxide production and growth. we show here that the addition of catalase to cultures enhanced the formation o ... | 2015 | 25894997 |
| left ventricular thrombus in a patient with cutaneous t-cell lymphoma, hypereosinophilia and mycoplasma pneumoniae infection - a challenging diagnosis: a case report. | differential diagnoses of cardiac masses include primary benign and malignant neoplasms, secondary neoplasms, and non-neoplastic masses, such as thrombi. owing to different therapeutic approaches and the way these affect the prognosis, the early and correct diagnostic determination of the etiology of a cardiac mass is of utmost importance and essential for the appropriate management of patients.we report a case of a 52-year-old woman with a left ventricular mass in the setting of a recent mycopl ... | 2015 | 25889614 |
| absence of inferior vena cava in 14-year old boy associated with deep venous thrombosis and positive mycoplasma pneumoniae serum antibodies--a case report. | absence of the inferior vena cava is a rare vascular anomaly, which usually remains asymptomatic in childhood. it is recognized as the risk factor for deep venous thrombosis, since the collateral circulation does not provide adequate drainage of the lower limbs. mycoplasma pneumoniae is a common cause of community-acquired pneumonia in school-aged children and adolescents. mycoplasma pneumoniae infection might be associated with deep venous thrombosis but its pathophysiology remains unknown. acc ... | 2015 | 25880637 |
| [a case report of pulmonary embolism associated with mycoplasma pneumoniae pneumonia]. | | 2015 | 25876692 |
| thrombocytopenia associated with mycoplasma pneumonia during pregnancy: case presentation and approach for differential diagnosis. | thrombocytopenia during pregnancy has many different causes, but mycoplasma pneumoniae is not usually considered one of the several pathogens that induce thrombocytopenia. herein, we present a case of severe thrombocytopenia that was associated with m. pneumoniae during pregnancy. the patient experienced fever, cough, and cytopenia with m. pneumoniae-specific igm antibody increasing from 40-fold to 160-fold during the 2 weeks of illness. a diagnosis was made after excluding other diseases that c ... | 2015 | 25873353 |
| characteristics of respiratory syncytial virus-induced bronchiolitis co-infection with mycoplasma pneumoniae and add-on therapy with montelukast. | the influence of mycoplasma pneumoniae (mp) infection on bronchiolitis remains unclear. additionally, reports on the efficacies of leukotriene receptor antagonists in the treatment of bronchiolitis have been inconclusive. | 2016 | 25846070 |
| macroscopic haemoglobinuria associated with mycoplasma pneumoniae infection successfully treated by clarithromycin. | a 25-year-old man developed macroscopic haemoglobinuria after a persistent dry cough. although chest radiograph findings were normal, since the serum antibody for mycoplasma pneumoniae was significantly elevated, a diagnosis infection with this organism was made. despite the absence of apparent anaemia, a marked increase in serum haemolytic markers and positive result for urine haemoglobin indicated the haemolysis of red blood cells, which was likely to have occurred secondarily to m. pneumoniae ... | 2015 | 25819056 |
| diagnostic sensitivity of a rapid antigen test for the detection of mycoplasma pneumoniae: comparison with real-time pcr. | a rapid antigen kit for the detection of the mycoplasma pneumoniae ribosomal protein l7/l12 using an immunochromatographic assay, ribotest mycoplasma, became available in japan in 2013. to determine the sensitivity of ribotest compared with real-time polymerase chain reaction (pcr), we prospectively performed these two tests simultaneously in adolescent and adult patients with community-acquired pneumonia (cap). in addition, we retrospectively analyzed the theoretical sensitivity of ribotest usi ... | 2015 | 25818195 |
| [etiologic deciphering of community-acquired pneumonia caused by mycoplasma pneumoniae]. | use of a complex of methods for etiologic deciphering of an acute respiratory infection. | 2015 | 25816527 |
| mycoplasma pneumoniae outbreak in a long-term care facility--nebraska, 2014. | on june 20, 2014, a nebraska long-term care facility notified the east central district health department (ecdhd) and nebraska department of health and human services (ndhhs) of an outbreak of respiratory illness characterized by cough and fever in 22 residents and resulting in four deaths during the preceding 2 weeks. to determine the etiologic agent, identify additional cases, and implement control measures, nebraska and cdc investigators evaluated the facility's infection prevention measures ... | 2015 | 25811678 |
| infectious and autoantibody-associated encephalitis: clinical features and long-term outcome. | pediatric encephalitis has a wide range of etiologies, clinical presentations, and outcomes. this study seeks to classify and characterize infectious, immune-mediated/autoantibody-associated and unknown forms of encephalitis, including relative frequencies, clinical and radiologic phenotypes, and long-term outcome. | 2015 | 25802349 |
| distinguishing between productive and abortive promoters using a random forest classifier in mycoplasma pneumoniae. | distinguishing between promoter-like sequences in bacteria that belong to true or abortive promoters, or to those that do not initiate transcription at all, is one of the important challenges in transcriptomics. to address this problem, we have studied the genome-reduced bacterium mycoplasma pneumoniae, for which the rnas associated with transcriptional start sites have been recently experimentally identified. we determined the contribution to transcription events of different genomic features: ... | 2015 | 25779052 |
| prevalence of mycoplasma pneumoniae: a cause for community-acquired infection among pediatric populaztion. | atypical pneumonia caused by mycoplasma pneumoniae is a leading cause of mortality among the pediatric age group. | 2015 | 25772918 |
| comparison of p1 and 16s rrna genes for detection of mycoplasma pneumoniae by nested pcr in adults in zhejiang, china. | mycoplasma pneumoniae (m. pneumoniae) is the most common atypical pathogen that causes respiratory infections in humans. laboratory tests are important in the diagnosis of m. pneumoniae because of the atypical features in clinical signs and symptoms. nowadays, both the p1 adhesin gene and 16s ribosomal (r) rna (rrna) gene of m. pneumoniae have been widely detected by polymerase chain reaction (pcr). the purpose of the present study was to evaluate the most suitable target in the detection of m. ... | 2015 | 25771461 |
| associations of il-2 and il-4 expression and polymorphisms with the risks of mycoplasma pneumoniae infection and asthma in children. | asthma is an inflammatory disorder of the airways and the symptoms of asthma could be exacerbated by mycoplasma pneumoniae infection. interleukin-2 and interleukin-4 have been implicated in immune and inflammatory reactions. we examined the associations of il2 and il4 polymorphisms and expression with the risks of asthma and m. pneumoniae infection in children. | 2015 | 25747600 |
| henoch-schönlein purpura triggered by mycoplasma pneumoniae in a female infant. | | 2015 | 25744240 |
| kinetic mechanism of l-α-glycerophosphate oxidase from mycoplasma pneumoniae. | l-α-glycerophosphate oxidase is an fad-dependent enzyme that catalyzes the oxidation of l-α-glycerophosphate (glp) by molecular oxygen to generate dihydroxyacetone phosphate (dhap) and hydrogen peroxide (h2o2). the catalytic properties of recombinant his6-glpo from mycoplasma pneumoniae (his6-mpglpo) were investigated through transient and steady-state kinetics and ligand binding studies. the results indicate that the reaction mechanism of his6-mpglpo follows a ping-pong model. double-mixing mod ... | 2015 | 25712468 |
| viruses detected by systematic multiplex polymerase chain reaction in adults with suspected community-acquired pneumonia attending emergency departments in france. | infectious agents associated with community-acquired pneumonia (cap) are under-studied. this study attempted to identify viruses from the upper respiratory tract in adults visiting emergency departments for clinically suspected cap. adults with suspected cap enrolled in the escaped study (impact of computed tomography on cap diagnosis) had prospective nasopharyngeal (np) samples studied by multiplex pcr (targeting 15 viruses and four intracellular bacteria). an adjudication committee composed of ... | 2015 | 25704448 |
| molecular typing of mycoplasma pneumoniae isolated from pediatric patients in tokyo, japan. | | 2015 | 25702792 |
| mycoplasma pneumoniae and chlamydia spp. infection in community-acquired pneumonia, germany, 2011-2012. | mycoplasma pneumoniae and chlamydia spp., which are associated with community-acquired pneumonia (cap), are difficult to propagate, and can cause clinically indistinguishable disease patterns. during 2011-2012, we used molecular methods to test adult patients in germany with confirmed cap for infection with these 2 pathogens. overall, 12.3% (96/783) of samples were positive for m. pneumoniae and 3.9% (31/794) were positive for chlamydia spp.; c. psittaci (2.1%) was detected more frequently than ... | 2015 | 25693633 |
| what's new with common, uncommon and rare rashes in childhood. | children with rashes account for many of the outpatient visits to a general pediatrician. as such, pediatricians are often the first to identify and treat these rashes. establishing an approach to common, uncommon and rare pediatric rashes assists in accurate assessment. this review highlights newly identified clinical patterns and disease severity. | 2015 | 25689452 |
| [analysis of 23s rrna of mycoplasma pneumoniae detected from pediatric inpatients with community-acquired pneumonia in a regional hospital in japan]. | | 2014 | 25672146 |