| syntheses and antibacterial activities of diterpene catechol derivatives with abietane, totarane and podocarpane skeletons against methicillin-resistant staphylococcus aureus and propionibacterium acnes. | natural catechol, quinone and quinone methide diterpenes with abietane (15-deoxyfuerstione, taxodione) and totarane (dispermone, 12,13-dihydroxy-8,11,13-totaratriene-6-one), and podocarpane (nimbidiol, deoxynimbidiol) skeletons were synthesized using ortho-oxidation of phenol with meta-chlorobenzoyl peroxide. minimum inhibitory activities of these diterpenes and previously synthesized natural diterpenes were measured against methicillin-resistant staphylococcus aureus (mrsa) and propionibacteriu ... | 2010 | 20522992 |
| detection of a new erm(x)-mediated antibiotic resistance in egyptian cutaneous propionibacteria. | a total of 107 antibiotic-resistant propionibacteria were isolated from the face of 102 egyptian acne patients, dermatology staff and controls. erythromycin-clindamycin-resistant propionibacteria were chosen to detect erm(x) gene and it was detected in 29 of 107 (27%) strains. however, just 7 strains had is1249i, 3 of them had also tn5432. the erm(x) gene which is not carried on tn5432 confers inducible resistance to telithromycin by erythromycin or clindamycin. the dna sequences of the pcr ampl ... | 2010 | 20541615 |
| glycerol/glucose co-fermentation: one more proficient process to produce propionic acid by propionibacterium acidipropionici. | cosubstrates fermentation is such an effective strategy for increasing subject metabolic products that it could be available and studied in propionic acid production, using glycerol and glucose as carbon resources. the effects of glycerol, glucose, and their mixtures on the propionic acid production by propionibacterium acidipropionici cgmcc1.2225 (atcc4965) were studied, with the aim of improving the efficiency of propionic acid production. the propionic acid yield from substrate was improved f ... | 2011 | 20544200 |
| metagenomic detection of phage-encoded platelet-binding factors in the human oral cavity. | the human oropharynx is a reservoir for many potential pathogens, including streptococcal species that cause endocarditis. although oropharyngeal microbes have been well described, viral communities are essentially uncharacterized. we conducted a metagenomic study to determine the composition of oropharyngeal dna viral communities (both phage and eukaryotic viruses) in healthy individuals and to evaluate oropharyngeal swabs as a rapid method for viral detection. viral dna was extracted from 19 p ... | 2011 | 20547834 |
| genome shuffling of propionibacterium shermanii for improving vitamin b12 production and comparative proteome analysis. | genome shuffling is an efficient approach for the rapid improvement of microbial phenotype. here we improved vitamin b12 production of propionibacterium shermanii by genome shuffling based on inactivated protoplast fusion. a genome shuffling strain with titer of vitamin b12 of 2.85 mgl(-1), named propionibacterium shermanii-f2-3, was obtained. the genome shuffled strain produced about 61% improvement of vitamin b12 over the parent strain after 96 h. comparative analysis of proteome profile was c ... | 2010 | 20553774 |
| delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns. | upon delivery, the neonate is exposed for the first time to a wide array of microbes from a variety of sources, including maternal bacteria. although prior studies have suggested that delivery mode shapes the microbiota's establishment and, subsequently, its role in child health, most researchers have focused on specific bacterial taxa or on a single body habitat, the gut. thus, the initiation stage of human microbiome development remains obscure. the goal of the present study was to obtain a co ... | 2010 | 20566857 |
| laser treatment of acne vulgaris. | traditional medical treatments for acne vulgaris include a variety of topical and oral medications. the combination of poor compliance, lack of durable remission, and potential side effects are common drawbacks to these treatments. the use of lasers and light devices has increased dramatically in recent years due to the overall ease of treatment, predictable clinical efficacy, and minimal adverse effects. a variety of light and laser devices has been used for the treatment of acne, including the ... | 2007 | 20567668 |
| laparoscopic ovarian tissue harvesting for cryopreservation: an effective and safe procedure for fertility preservation. | to critically review our experience with the method of laparoscopic ovarian tissue harvesting for ovarian cryopreservation. | 2010 | 20580151 |
| evaluation of the epinecidin-1 peptide as an active ingredient in cleaning solutions against pathogens. | we tested the activity of epinecidin-1, a novel antimicrobial peptide structurally related to pleurocidin, in commercial cleaning solutions stored at 4 and 25 degrees c for 7 and 14 days. the peptide's activities against enterococcus faecalis, escherichia coli, klebsiella oxytoca, pseudomonas aeruginosa, staphylococcus aureus, propionibacterium acnes, and candida albicans were measured in a minimum inhibitory concentration (mic) determination, minimal bactericidal concentration (mbc) determinati ... | 2010 | 20580756 |
| treatment of progressive macular hypomelanosis with narrow-band ultraviolet b phototherapy. | treatment for progressive macular hypomelanosis (pmh) has been disappointing. recently, propionibacterium acnes had been postulated as the causative agent and narrow-band ultraviolet b (nbuvb) had been shown to stimulate melanogenesis and has antibacterial properties. the aim of this study was to evaluate the effectiveness of nbuvb in the treatment of pmh. a retrospective analysis of pmh cases diagnosed and treated with nbuvb treatment from 1 january 2007 to 30 april 2009 at the national skin ce ... | 2010 | 20584255 |
| progressive macular hypomelanosis: a rarely diagnosed hypopigmentation in caucasians. | a 35-year-old woman who developed whitish macules on trunk and limbs at 12 years of age and observed a remarkable increase of the hypopigmentated lesions after her pregnancies at ages 29 and 32 years. because of the highly characteristic clinical aspect and the light- and electron-microscopic histopathologic findings, we diagnosed progressive macular hypomelanosis (pmh). it is a nonscaly disorder with hypopigmented macules mainly on the trunk and is more often seen in young women. in contrast to ... | 2009 | 20585481 |
| propionic acid fermentation by propionibacterium freudenreichii cctcc m207015 in a multi-point fibrous-bed bioreactor. | propionic acid was produced in a multi-point fibrous-bed (mfb) bioreactor by propionibacterium freudenreichii cctcc m207015. the mfb bioreactor, comprising spiral cotton fiber packed in a modified 7.5-l bioreactor, was effective for cell-immobilized propionic acid production compared with conventional free cell fermentation. batch fermentations at various glucose concentrations were investigated in the mfb bioreactor. based on analysis of the time course of production, a fed-batch strategy was a ... | 2010 | 20589397 |
| [clinical relevance of time-to-positivity in bactec9240 blood culture system]. | continuous monitoring systems have allowed determination of the time-to-positivity (ttp). we evaluated the clinical relevance of ttp in the bactec9240 system (becton-dickinson, usa). | 2010 | 20603588 |
| plasma concentration of propionibacterium acnes antibodies and prostate cancer risk: results from an australian population-based case-control study. | recent studies in prostatic tissue suggest that propionibacterium acnes (p. acnes), a bacterium associated with acne that normally lives on the skin, is the most prevalent bacterium in the prostate and in men with benign prostatic hyperplasia. its prevalence is higher in samples from patients subsequently diagnosed with prostate cancer. the aim of our study was to test whether circulating levels of p. acnes antibodies are associated with prostate cancer risk and tumour characteristics using plas ... | 2010 | 20606679 |
| acne epidemiology and pathophysiology. | the demographic profile of facial acne vulgaris has changed during the past several decades; 12 years of age is no longer the low end of the "normal" range for onset of acne. the available epidemiologic evidence raises more questions than it answers regarding the etiology of this downward shift. more study is needed to clarify whether the trend toward an earlier onset of puberty in the united states has influenced the clinical picture of acne. additional research will help advance understanding ... | 2010 | 20610306 |
| optimization and scale-up of propionic acid production by propionic acid-tolerant propionibacterium acidipropionici with glycerol as the carbon source. | propionic acid production by propionibacterium acidipropionici with glycerol as sole carbon source was studied in 7-l batch and 10m(3) bioreactor cultures. in batch cultures, propionic acid production increased and specific cell growth rate decreased with increasing glycerol concentrations. maximum propionic acid production and productivity reached 44.62+/-1.12g/l and 0.20+/-0.0075gl(-1)h(-1)at 220h, respectively, when glycerol was fed at a constant rate of 0.01l/h from 72 to 120h with an initia ... | 2010 | 20620054 |
| specific metabolic activity of ripening bacteria quantified by real-time reverse transcription pcr throughout emmental cheese manufacture. | bacterial communities of fermented foods are usually investigated by culture-dependent methods. real-time quantitative pcr (qpcr) and reverse transcription (rt)-qpcr offer new possibilities to quantify the populations present and their metabolic activity. the aim of this work was to develop qpcr and rt-qpcr methods to assess the metabolic activity and the stress level of the two species used as ripening cultures in emmental cheese manufacture, propionibacterium freudenreichii and lactobacillus p ... | 2010 | 20630608 |
| the tlr4/trif-mediated activation of nlrp3 inflammasome underlies endotoxin-induced liver injury in mice. | administration of heat-killed propionibacterium acnes renders mice highly susceptible to lps. after lps challenge p. acnes-primed mice promptly show hypothermia, hypercoagulation (disseminated intravascular coagulation), elevation of serum proinflammatory cytokine levels, and high mortality. the surviving mice develop liver injury. as previously reported, il-18 plays a pivotal role in the development of this liver injury. many cell types including macrophages constitutively store il-18 as biolog ... | 2010 | 20634907 |
| minocycline in acne vulgaris: benefits and risks. | minocycline is a semi-synthetic, second-generation tetracycline. it was introduced in 1972 and has both antibacterial and anti-inflammatory properties. minocycline is used for a variety of infectious diseases and in acne. even today, new indications beyond the antibacterial indications are being investigated such as its use in neurologic diseases. formerly, minocycline was thought to have a superior efficacy in the treatment of inflammatory acne, especially with respect to antibacterial-resistan ... | 2010 | 20642295 |
| efficacy of benzoyl peroxide (5.3%) emollient foam and benzoyl peroxide (8%) wash in reducing propionibacterium acnes on the back. | topical treatment of acne vulgaris on the back is challenging largely due to the extensive broad surface with difficult to reach areas. a "leave-on" foam is suited for application to the trunk due to ease of application and spreadability. prior to this trial, no data on propionibacterium acnes (p. acnes) reduction on the back has existed for any benzoyl peroxide (bp) formulations or other acne treatments. | 2010 | 20645523 |
| the development of antimicrobial resistance due to the antibiotic treatment of acne vulgaris: a review. | to review recent studies on the use of antibiotics in acne vulgaris which provide insight into the development of antimicrobial resistance. | 2010 | 20645527 |
| antibacterial activity of thai herbal extracts on acne involved microorganism. | ethyl acetate and methanol extracts of 18 thai medicinal plants were investigated for their antibacterial activity against propionibacterium acnes, stapylococcus aureus, and s. epidermidis. thirteen plant extracts were capable of inhibiting the growth of p. acnes and s. epidermidis, while 14 plant extracts exhibited an inhibitory effect on s. aureus. based on the broth dilution method, the ethyl acetate extract of alpinia galanga (l.) wild. (zingiberaceae) rhizome showed the strongest antibacter ... | 2010 | 20645714 |
| free radical scavenging and anti-acne activities of mangosteen fruit rind extracts prepared by different extraction methods. | the ethanol extracts of mangosteen fruit rinds prepared by several extraction methods were examined for their contents of bioactive compounds, dpph-scavenging activity, and anti-acne producing bacteria against propionibacterium acnes and staphylococcus epidermidis. the dried powder of the fruit rind was extracted with 95% ethanol by maceration, percolation, soxhlet extraction, ultrasonic extraction, and extraction using a magnetic stirrer. soxhlet extraction promoted the maximum contents of crud ... | 2010 | 20645837 |
| infected rathke cleft cysts: distinguishing factors and factors predicting recurrence. | rathke cleft cysts (rccs) are benign sellar lesions that are generally asymptomatic but sometimes warrant transsphenoidal drainage. small case reports have described infected rccs, but this phenomenon remains uncharacterized. | 2010 | 20651624 |
| activities of ten essential oils towards propionibacterium acnes and pc-3, a-549 and mcf-7 cancer cells. | ten essential oils, namely, mint (mentha spicata l., lamiaceae), ginger (zingiber officinale rosc., zingiberaceae), lemon (citrus limon burm.f., rutaceae), grapefruit (citrus paradisi macf., rutaceae), jasmine (jasminum grandiflora l., oleaceae), lavender (mill., lamiaceae), chamomile (matricaria chamomilla l., compositae), thyme (thymus vulgaris l., lamiaceae), rose (rosa damascena mill., rosaceae) and cinnamon (cinnamomum zeylanicum n. lauraceae) were tested for their antibacterial activities ... | 2010 | 20657472 |
| toll-like receptor (tlr)-9 genetics and function in sarcoidosis. | sarcoidosis is a systemic disorder characterized by the formation of non-caseating granulomas in variable organs. toll-like receptor (tlr)-9 is important in the innate immune response against both mycobacterium tuberculosis and propionibacterium acnes, candidate causative agents in sarcoidosis. the aim of our study was to investigate possible genetic and functional differences in tlr-9 between patients and controls. tlr-9 single nucleotide polymorphisms were genotyped in 533 patients and divided ... | 2010 | 20659127 |
| the clinical features of late onset acne compared with early onset acne in women. | little is known about the clinical characteristics of acne based on the age of onset. | 2011 | 20659307 |
| the etiologic role of infectious antigens in sarcoidosis pathogenesis. | sarcoidosis is a disease of unknown etiology, characterized pathologically by noncaseating granulomas that most commonly involve the lung, skin, lymph nodes, and eyes. syndromes with similar pathological and immunologic features to sarcoidosis such as chronic beryllium disease, hypersensitivity pneumonitis, and tuberculosis illustrate that granulomatous diseases may or may not have an infectious etiology. although the etiology of sarcoidosis remains unknown, recent molecular, genetic, and immuno ... | 2010 | 20665387 |
| the complete genome of propionibacterium freudenreichii cirm-bia1, a hardy actinobacterium with food and probiotic applications. | propionibacterium freudenreichii is essential as a ripening culture in swiss-type cheeses and is also considered for its probiotic use. this species exhibits slow growth, low nutritional requirements, and hardiness in many habitats. it belongs to the taxonomic group of dairy propionibacteria, in contrast to the cutaneous species p. acnes. the genome of the type strain, p. freudenreichii subsp. shermanii cirm-bia1 (cip 103027(t)), was sequenced with an 11-fold coverage. | 2010 | 20668525 |
| antenatal antecedents of a small head circumference at age 24-months post-term equivalent in a sample of infants born before the 28th post-menstrual week. | little is known about the antecedents of microcephaly in early childhood among children born at extremely low gestational age. | 2010 | 20674197 |
| acne and diet: truth or myth? | numerous studies were published over the last 50 years to investigate whether diet is associated with the etiology of acne. although older studies well known by dermatologists that refute the association between acne and diet exist, their scientific foundation is weak. new articles have recently brought to light evidence contrary to previous findings. therefore, we would like to investigate whether diet, directly or indirectly, influences one or more of the four fundamental etiopathogenic pillar ... | 2010 | 20676468 |
| [microbial contamination of nipradiol with and without benzalkonium chloride]. | to compare microbial contamination of nipradiol both with and without benzalkonium chloride (bac). | 2010 | 20681256 |
| innate, antigen-independent role for t cells in the activation of the immune system by propionibacterium acnes. | propionibacterium acnes is a human commensal but also an opportunistic pathogen. in mice, p. acnes exerts strong immunomodulatory activities, including formation of intrahepatic granulomas and induction of lps hypersensitivity. these activities are dependent on p. acnes recognition via tlr9 and subsequent il-12-mediated ifn-gamma production. we show that p. acnes elicits il-12p40 and p35 mrna expression in macrophages, and ifn-gamma mrna in liver cd4(+) t cells and nk cells. after priming with p ... | 2010 | 20690177 |
| does inflammatory acne result from imbalance in the keratinocyte innate immune response? | acne is a multifactorial chronic disease affecting around 80% of teenage population. the pathogenesis of acne involves inflammatory reactions and colonization by the propionibacterium acnes (p. acnes) strain. p. acnes stimulates the keratinocytes involved in the innate immune response, the intensity of which could be influenced either by bacterial intrinsic factors or by endogenous factors of the host. | 2010 | 20691803 |
| protease-activated receptor-2 mediates the expression of inflammatory cytokines, antimicrobial peptides, and matrix metalloproteinases in keratinocytes in response to propionibacterium acnes. | propionibacterium acnes (p. acnes) has been known to produce various exogenous proteases, however, their role in acne pathogenesis remains largely unknown. proteases elicit cellular responses, at least in part, via proteinase-activated receptor-2 (par-2), which is known to mediate inflammation and immune response. in this study, we investigated whether proteases from p. acnes could activate par-2 on keratinocytes and induce pro-inflammatory cytokines, antimicrobial peptides (amps), and matrix me ... | 2010 | 20697725 |
| quantitation of major human cutaneous bacterial and fungal populations. | because the human skin microbiota may play roles in the causation or modification of skin diseases, we sought to provide initial quantitative analysis from different cutaneous locations. we developed quantitative pcrs to enumerate the total bacterial and fungal populations, as well as the most common bacterial and fungal genera present in six locales, in eight healthy subjects. we used a set of primers and taqman mgb probes based on the bacterial 16s rrna and fungal internally transcribed spacer ... | 2010 | 20702672 |
| carotid artery reconstruction for infected carotid patches. | infected carotid prosthetic patches (icpp) are a rare but catastrophic complication of carotid endarterectomy (cea). prevention and appropriate surgical management is essential. we report our experience of carotid artery reconstruction for icpp. | 2010 | 20705492 |
| production of folate by bacteria isolated from oat bran. | twenty bacteria isolated from three commercial oat bran products were tested for their folate production capability. the bacteria as well as some reference organisms were grown until early stationary phase on a rich medium (ypd), and the amount of total folate in the separated cell mass and the culture medium (supernatant) was determined by microbiological assay. folate vitamer distribution was determined for eight bacteria including one isolated from rye flakes. for seven bacteria the effect of ... | 2010 | 20708290 |
| biopolymer scaffolds for use in delivering antimicrobial sophorolipids to the acne-causing bacterium propionibacterium acnes. | sophorolipids (sls) are known to possess antimicrobial properties towards many species (particularly gram-positive, or gram(+)) of bacteria. however, these properties can only be exerted if the sls can be introduced to the bacterial cells in an acceptable manner. propionibacterium acnes is the common bacterial cause of acne. it is a gram(+) facultative anaerobe that is susceptible to the antimicrobial effects of sls. in this study we demonstrated that different biopolymer matrices could be used ... | 2011 | 20708720 |
| sinogenic orbital and subperiosteal abscesses: microbiology and methicillin-resistant staphylococcus aureus incidence. | to assess the current bacteriology and the incidence of methicillin-resistant staphylococcus aureus in orbital and subperiosteal abscesses of paranasal sinus disease origin. | 2010 | 20723777 |
| expression of toll-like receptor 2 on peripheral blood monocytes of patients with inflammatory and noninflammatory acne vulgaris. | the pathogenesis of acne vulgaris is multifactorial and entails the interplay of hormonal, microbial and immunological events. the bacterium propionibacterium acnes is involved in the induction of comedogenesis and maintenance of the inflammatory phase of acne. toll-like receptor 2 (tlr2) expressed on mononuclear inflammatory cells and possibly on keratinocytes and sebocytes is thought to be of vital importance in mediating p. acnes-induced inflammatory response in acne vulgaris. this work aimed ... | 2009 | 20726329 |
| propionibacterium acnes and staphylococcus epidermidis isolated from refractory endodontic lesions are opportunistic pathogens. | the predominant cultivable microbiota from 20 refractory endodontic lesions (9 with abscesses and 11 without abscesses) were determined, and propionibacterium acnes and staphylococcus epidermidis were among the most predominant organisms. the number of species identified from lesions with abscesses (14.1 ± 2.6) was significantly greater (p < 0.001) than the number from lesions without abscesses (7.4 ± 5.9). comparison of perioral isolates using repetitive extragenic palindromic pcr of the same s ... | 2010 | 20739494 |
| proteomic identification of secreted proteins of propionibacterium acnes. | the anaerobic gram-positive bacterium propionibacterium acnes is a human skin commensal that resides preferentially within sebaceous follicles; however, it also exhibits many traits of an opportunistic pathogen, playing roles in a variety of inflammatory diseases such as acne vulgaris. to date, the underlying disease-causing mechanisms remain ill-defined and knowledge of p. acnes virulence factors remains scarce. here, we identified proteins secreted during anaerobic cultivation of a range of sk ... | 2010 | 20799957 |
| taurine bromamine (taubr)--its role in immunity and new perspectives for clinical use. | this review is an attempt to summarize our knowledge about taurine bromamine (taubr) properties, its role in innate immunity and its therapeutic potential.taubr and taurine chloramine (taucl) are major haloamines generated by eosinophils and neutrophils at a site of inflammation. both haloamines share anti-inflammatory and anti-oxidant properties. taubr, similarly to taucl, decreases the production of proinflammatory mediators. their anti-inflammatory and anti-oxidant activities are enhanced by ... | 2010 | 20804605 |
| population genetic analysis of propionibacterium acnes identifies a subpopulation and epidemic clones associated with acne. | the involvement of propionibacterium acnes in the pathogenesis of acne is controversial, mainly owing to its dominance as an inhabitant of healthy skin. this study tested the hypothesis that specific evolutionary lineages of the species are associated with acne while others are compatible with health. phylogenetic reconstruction based on nine housekeeping genes was performed on 210 isolates of p. acnes from well-characterized patients with acne, various opportunistic infections, and from healthy ... | 2010 | 20808860 |
| effects of two commercially available immunostimulants on leukocyte function of foals following ex vivo exposure to rhodococcus equi. | the objective of this study was to determine the effect of immunostimulants on neutrophil, macrophage, and lymphocyte function following ex vivo exposure to rhodococcus equi. eighteen foals were randomly assigned to one of 3 treatment groups. treatment consisted of inactivated propionibacterium acnes (pa), inactivated parapoxvirus ovis (ppvo), or saline (control) administered on days 0 (7 days of age), 2, and 8. bronchoalveolar lavage (bal) fluid and blood were collected on days 0 (baseline), 12 ... | 2010 | 20822815 |
| bacterial 16s sequence analysis of severe caries in young permanent teeth. | previous studies have confirmed the association of the acid producers streptococcus mutans and lactobacillus spp. with childhood caries, but they also suggested these microorganisms are not sufficient to explain all cases of caries. in addition, health-associated bacterial community profiles are not well understood, including the importance of base production and acid catabolism in ph homeostasis. the bacterial community composition in health and in severe caries of the young permanent dentition ... | 2010 | 20826648 |
| the potential use of echinacea in acne: control of propionibacterium acnes growth and inflammation. | acne is a chronic inflammatory disorder of skin follicles caused by the gram-positive bacterium propionibacterium acnes. the possibility was investigated that a standardized preparation of echinacea purpurea (echinaforce®), with known antiviral, antiinflammatory and antibacterial properties, might provide a useful alternative treatment in the control of the disease. the herbal extract readily killed a standard laboratory strain of the bacterium and several clinical isolates. in cell culture mode ... | 2011 | 20830697 |
| [antibacterial activity against 224 clinical bacterial strains of jca 250 and jca 251 compounds containing essential oils provided from aroma technologies research]. | it was to determine the antibacterial spectrum of jca 250 and jca 251, two naturally occurring compounds from aroma technologies research, on a bacterial population isolated from clinical infections. | 2011 | 20832194 |
| activity of an antimicrobial hydrocephalus shunt catheter against propionibacterium acnes. | shunt infection is a major complication affecting approximately 10% of procedures. propionibacterium acnes, an anaerobic skin bacterium, is increasingly recognized as a shunt pathogen, causing up to 14% of infections. though susceptible to penicillin and cephalosporins, p. acnes shunt infections are not preventable by means of perioperative prophylaxis, due to poor cerebrospinal fluid penetration. antimicrobial shunts with activity against staphylococci are available, but their activity against ... | 2010 | 20837763 |
| effect of a multispecies probiotic supplement on quantity of irritable bowel syndrome-related intestinal microbial phylotypes. | probiotics can alleviate the symptoms of irritable bowel syndrome (ibs), possibly by stabilizing the intestinal microbiota. our aim was to determine whether ibs-associated bacterial alterations were reduced during multispecies probiotic intervention consisting of lactobacillus rhamnosus gg, l. rhamnosus lc705, propionibacterium freudenreichii ssp. shermanii js and bifidobacterium breve bb99. the intervention has previously been shown to successfully alleviate gastrointestinal symptoms of ibs. | 2010 | 20849659 |
| bilateral clavicle fracture external fixation. | fractures of the middle third of the clavicle are frequent and their conservative treatment ends in bone union in nearly 95% of cases. surgical treatment is unanimously indicated with open fractures or in cases of cutaneous damage, neurovascular complications, and impaction of the shoulder stump syndromes. we report herein a case of bilateral fractures of the clavicle that required double stabilization with an external fixator following major cutaneous damage appearing after the initial conserva ... | 2010 | 20850405 |
| mutagenesis of propionibacterium acnes and analysis of two camp factor knock-out mutants. | p. acnes is a skin commensal that is frequently associated with inflammatory diseases such as acne vulgaris. despite the availability of the genome sequence functional studies on p. acnes are scarce due to a lack of methods for genetic manipulation of this bacterium. here we present an insertional mutagenesis approach for the inactivation of specific p. acnes genes. the gene of interest can be disrupted and replaced with an erythromycin-resistance cassette by employing homologous recombination. ... | 2010 | 20850482 |
| apical root canal microbiota as determined by reverse-capture checkerboard analysis of cryogenically ground root samples from teeth with apical periodontitis. | bacteria located in the apical root canal system potentially participate in the pathogenesis of apical periodontitis. detection and identification of apical bacteria can be compromised because of limitations in conventional sampling and identification procedures. this study identified several bacterial taxa in the apical and middle/coronal segments of primarily infected root canal system by using pulverized root segments and a culture-independent molecular method. | 2010 | 20850664 |
| isolation of a novel bacteriophage specific for the periodontal pathogen fusobacterium nucleatum. | fusobacterium nucleatum is a periodontal pathogen that has been directly associated with the development and progression of periodontal disease, a widespread pathology that affects the support tissues of the tooth. we isolated a new bacteriophage (fnpφ02) that specifically infects this bacterium. transmission electron microscopy showed that the virion is composed of an icosahedral head and a segmented tail. the size of the phage genome was estimated to be approximately 59 kbp of double-stranded ... | 2010 | 20851973 |
| [evaluating post-cataract surgery changes in bacterial culture tests with and without face-washing]. | to evaluate the changes in conjunctiva and eyelid culture test results before and after cataract surgery and their relation to face-washing. | 2010 | 20865920 |
| development of a nondestructive fluorescence-based enzymatic staining of microcolonies for enumerating bacterial contamination in filterable products. | develop a nondestructive fluorescence-based staining procedure to rapidly detect and enumerate bacteria in filterable samples. | 2010 | 20880209 |
| photodynamic therapy in the management of acne: an update. | acne, one of the most common dermatological diseases, is characterized by inflammatory and noninflammatory lesions that may progress to scars. starting from pubertal age groups, it can affect adults in the age group 35-40 or more. the conventional therapies for treatment of acne are facing roadblocks because of the antibiotic resistance developing against propionibacterium acnes. this has led to trying new therapies, of which photodynamic therapy (pdt) seems to be the one under intensive study. ... | 2010 | 20883294 |
| cutaneous malassezia microbiota in atopic dermatitis patients differ by gender and body part. | malassezia is a particularly important factor in the occurrence of atopic dermatitis (ad). | 2010 | 20924162 |
| propionibacterium acnes activates the igf-1/igf-1r system in the epidermis and induces keratinocyte proliferation. | propionibacterium acnes has a major role in the development of acne lesions. igf-1 stimulates the proliferation of keratinocytes via an activation of the igf-1 receptor (igf-1r). zinc has been proven to work efficiently against inflammatory acne and to modulate the igf-1 system. our objectives were to study the modulation of igf-1 and igf-1r expression by p. acnes extracts and to determine their modulation by zinc gluconate. in vivo, we analyzed biopsies of acne lesions and healthy skin, and in ... | 2010 | 20927124 |
| in vitro antimicrobial susceptibility of propionibacterium acnes isolated from acne patients in northern mexico. | antimicrobials are essential in acne therapy. in the last decades, propionibacterium acnes has become resistant to different antibiotics. | 2010 | 20931669 |
| prevalence of propionibacterium acnes in diseased prostates and its inflammatory and transforming activity on prostate epithelial cells. | prostate cancer (pca) is the second leading cause of male cancer deaths in the western world. mounting evidence has revealed that chronic inflammation can be an important initiating factor of pca. recent work has detected the anaerobic gram-positive bacterium propionibacterium acnes in cancerous prostates, but with wide-ranging detection rates. here, using in situ immunofluorescence (isif), p. acnes was found in 58 out of 71 (81.7%) tested cancerous prostate tissue samples, but was absent from h ... | 2010 | 20943438 |
| fermentation metabolites from lactobacillus gasseri and propionibacterium freudenreichii exert bacteriocidal effects in mice. | lactobacillus gasseri oll 2716 promotes the elimination of helicobacter pylori and is utilized in yogurts that are specifically labeled as health foods. on the other hand, milk whey fermented by propionibacterium freudenreichii et-3, which increases the numbers of bifidobacterium, is effective for intestinal disorders. we previously demonstrated that oral administration of l. gasseri and p. freudenreichii fermentation metabolites (lp-fm) improved calf intestinal microflora and reduced the incide ... | 2010 | 20954806 |
| time course and specificity of lipolysis in swiss cheese. | controlling lipolysis in cheese is necessary to ensure the formation of desirable flavor. to get a better understanding of the mechanism of lipolysis in swiss cheese, cheeses were manufactured with and without (control) the addition of propionibacterium freudenreichii. products of lipolysis were quantified throughout ripening. half of the free fatty acids (ffa) released in milk (3.66 mg/g fat), in particular the short-chain ffa, were lost in the whey during curd drainage, whereas diglycerides an ... | 2010 | 20961108 |
| propioniciclava tarda gen. nov., sp. nov., isolated from a methanogenic reactor treating waste from cattle farms. | facultatively anaerobic bacterial strains (wr061(t)and wr054) were isolated from rice-straw residue in a methanogenic reactor treating waste from cattle farms in japan. the two strains had almost the same phylogenetic and phenotypic properties. cells were gram-staining-positive, non-motile, non-spore-forming, irregular rods. the strains required cobalamin (vitamin b(12)). the strains utilized various carbohydrates including hexoses and disaccharides. the strains produced acetate and propionate f ... | 2010 | 20971831 |
| promising immunomodulatory effects of selected strains of dairy propionibacteria as evidenced in vitro and in vivo. | immunomodulatory properties of 10 dairy propionibacteria, analyzed on human peripheral blood mononuclear cells (pbmcs), revealed a highly strain-dependent induction of anti-inflammatory cytokine interleukin 10 (il-10). two selected strains of propionibacterium freudenreichii showed a protective effect against two models of colitis in mice, suggesting a probiotic potential predicted by immune-based selection criteria for these cheese starter bacteria. | 2010 | 20971874 |
| bacterial contamination of needles used for intravitreal injections: a prospective, multicenter study. | to determine the incidence of bacterial contamination of needles used for intravitreal injections. | 2010 | 21034310 |
| mis416, a non-toxic microparticle adjuvant derived from propionibacterium acnes comprising immunostimulatory muramyl dipeptide and bacterial dna promotes cross-priming and th1 immunity. | propionibacterium acnes was modified using biochemical extraction methods generating a suspension of microparticles (mis416) comprising a minimal cell wall skeleton rich in immunostimulatory crosslinked muramyl dipeptide repeats and native bacterial dna fragments, each which have known adjuvant activity. in vitro studies demonstrated that mis416 was readily internalized by human myeloid and plasmacytoid dc inducing cytokine secretion and cell activation/maturation. vaccination studies in mice us ... | 2010 | 21034827 |
| the unconventional antimicrobial peptides of the classical propionibacteria. | the classical propionibacteria produce genetically unique antimicrobial peptides, whose biological activities are without equivalents, and to which there are no homologous sequences in public databases. in this review, we summarize the genetics, biochemistry, biosynthesis, and biological activities of three extensively studied antimicrobial peptides from propionibacteria. the propionicin t1 peptide constitutes a bona fide example of an unmodified general secretory pathway (sec)-dependent bacteri ... | 2010 | 21038096 |
| detection of microbial contaminants in mammalian cell cultures using a new fluorescence-based staining method. | microbial contamination of cell culture production processes is a current concern for biopharmaceutical industries. traditional testing methods require several days to detect contamination and may advantageously be replaced by a rapid detection method. we developed a new method combining membrane filtration to microcolonies fluorescence staining method (mfsm) and compared it to epifluorescence microscopy. | 2010 | 21039669 |
| pelvic actinomycosis-like disease due to propionibacterium propionicum after hysteroscopic removal of an intrauterine device. | a female patient presented with episodes of fever and pain in the lower right abdomen after hysteroscopic removal of an intrauterine device 2 months earlier. pelvic actinomycosis originating from a tubo-ovarian abscess was diagnosed with propionibacterium propionicum, formerly known as arachnia propionica, as causative agent. | 2010 | 21068286 |
| efficacy and safety of combined ethinyl estradiol/drospirenone oral contraceptives in the treatment of acne. | acne is a common disorder affecting the majority of adolescents and often extends into adulthood. the central pathophysiological feature of acne is increased androgenic stimulation and/or end-organ sensitivity of pilosebaceous units leading to sebum hypersecretion and infundibular hyperkeratinization. these events lead to propionibacterium acnes proliferation and subsequent inflammation. hormonal therapy, including combined oral contraceptives (ocs), can attenuate the proximate androgenic trigge ... | 2010 | 21072290 |
| construction of metabolically biotinylated adenovirus with deleted fiber knob as targeting vector. | gene delivery vectors based on adenovirus, particularly human adenovirus serotype 5 (had5) have great potential for the treatment of variety of diseases. however, the tropism of had5 needs to be modified to achieve tissue- or cell- specific therapies for the successful application of this vector system to clinic. here, we modified had5 tropism by replacing the fiber knob which contains the coxsackievirus b and adenovirus receptor (car)-binding sites with a biotin acceptor peptide, a truncated fo ... | 2010 | 21073735 |
| persistence of probiotic strains in the gastrointestinal tract when administered as capsules, yoghurt, or cheese. | most clinical studies of probiotics use freeze-dried, powdered bacteria or bacteria packed in capsules. however, probiotics are commercially available in various food matrices, which may affect their persistence in the gastrointestinal tract. the objective of the study was to compare oral and faecal recovery during and after administration of a combination of lactobacillus rhamnosus gg and lc705, propionibacterium freudenreichii subsp. shermanii js, and bifidobacterium animalis subsp. lactis bb1 ... | 2010 | 21074284 |
| benzoyl peroxide: enhancing antibiotic efficacy in acne management. | benzoyl peroxide is one of the most widely used topical agents for acne. it has potent antibacterial and mild anti-inflammatory and comedolytic effects. to treat mild to moderate acne, it can be used alone or in combination with topical antibiotics and topical retinoids. the combination of benzoyl peroxide with either erythromycin or clindamycin is synergistic and well-tolerated. in more severe acne, when oral antibiotics are required, benzoyl peroxide can contribute to suppressing the emergence ... | 2010 | 21076800 |
| potent antimicrobial action of triclosan-lysozyme complex against skin pathogens mediated through drug-targeted delivery mechanism. | triclosan (tcs), an antimicrobial agent that inhibits bacterial fatty acid synthesis by blocking the active site of enoyl-acp reductase (fabi), is a water-insoluble agent that limits its therapeutic candidacy. we have recently shown that the water solubility and antimicrobial activity of tcs were greatly enhanced when complexed to lysozyme (lz). this study is to examine the therapeutic potential of triclosan-lysozyme (t-lz) complex against common skin pathogens expressing different levels of fab ... | 2010 | 21078387 |
| the bifidogenic growth stimulator inhibits the growth and respiration of helicobacter pylori. | triple therapy with amoxicillin, clarithromycin, and a proton-pump inhibitor is a common therapeutic strategy for the eradication of helicobacter pylori (h. pylori). however, frequent appearance of clarithromycin-resistant strains is a therapeutic challenge. while various quinones are known to specifically inhibit the growth of h. pylori, the quinone 1,4-dihydroxy-2-naphthoic acid (dhna) produced by propionibacterium has strong stimulating effect on bifidobacterium. we were interested to see whe ... | 2010 | 21083748 |
| staphylococcus aureus hijacks a skin commensal to intensify its virulence: immunization targeting β-hemolysin and camp factor. | the need for a new anti-staphylococcus aureus therapy that can effectively cripple bacterial infection, neutralize secretory virulence factors, and lower the risk of creating bacterial resistance is undisputed. here, we propose what is, to our knowledge, a previously unreported infectious mechanism by which s. aureus may commandeer propionibacterium acnes, a key member of the human skin microbiome, to spread its invasion and highlight two secretory virulence factors (s. aureus β-hemolysin and p. ... | 2010 | 21085191 |
| [how i explore...skin by photodiagnosis using skin fluorescence and its functional imaging]. | under specific light illumination, skin produces peculiar fluorescent aspects. such property can be used to provide diagnostic arguments or to disclose some peculiar functions of the skin. some superficial infections (erythrasma, tinea versicolor, dermatophytic tinea,..) reveal fluorescence that may be intense. the pilosebaceous follicles enriched in propionibacterium spp show fluorescence. such property is lost during some anti-acne treatments. a quenching effect is observed after application o ... | 2010 | 21086585 |
| fluorescence diagnostic imaging in patients with acne. | orange-red fluorescence in the follicle openings, induced by ultraviolet a light, originates from porphyrins, the metabolic products of propionibacteria acnes. | 2010 | 21091785 |
| [pathophysiological advances in acne]. | acne is a chronic disorder caused by multiple factors. recent advances suggest that inflammation plays an initial role and propionibacterium acnes plays a major role by initiating, maintaining and extending acne. | 2010 | 21095495 |
| a review of the safety and efficacy of benzoyl peroxide (5.3%) emollient foam in the management of truncal acne vulgaris. | this article reviews findings of studies regarding the treatment of truncal acne with benzoyl peroxide formulations and, in particular, studies utilizing a 5.3% benzoyl peroxide foam. its formulation of micronized benzoyl peroxide particles in an emollient foam vehicle offers significant clinical and bioavailability advantages that enhance follicular penetration and skin moisturization. a key consideration for topical management of truncal acne is whether the treatment application method allows ... | 2010 | 21103313 |
| tlr2 expression is increased in rosacea and stimulates enhanced serine protease production by keratinocytes. | a diverse environment challenges skin to maintain temperature, hydration, and electrolyte balance while also maintaining normal immunological function. rosacea is a common skin disease that manifests unique inflammatory responses to normal environmental stimuli. we hypothesized that abnormal function of innate immune pattern recognition could explain the enhanced sensitivity of patients with rosacea, and observed that the epidermis of patients with rosacea expressed higher amounts of toll-like r ... | 2010 | 21107351 |
| proteomics integrated with escherichia coli vector-based vaccines and antigen microarrays reveals the immunogenicity of a surface sialidase-like protein of propionibacterium acnes. | proteomics is a powerful tool for the identification of proteins, which provides a basis for rational vaccine design. however, it is still a highly technical and time-consuming task to examine a protein's immunogenicity utilizing traditional approaches. here, we present a platform for effectively evaluating protein immunogenicity and antibody detection. a tetanus toxin c fragment (tet-c) was used as a representative antigen to establish this platform. a cell wall-anchoring sialidase-like protein ... | 2008 | 21136919 |
| bacteriologic culture of excised intervertebral disc from immunocompetent patients undergoing single level primary lumbar microdiscectomy. | study design: a consecutive case series from a single center of patients undergoing primary microdiscectomy for lumbar herniated nucleus pulposus (hnp) who received microbiologic laboratory culture of excised disc material. objective: to determine the prevalence of positive bacterial cultures in the disc material of immunocompetent patients without diabetes mellitus or other immune compromise. summary of background data: the intradiscal space is a physiologically tenuous environment in terms of ... | 2010 | 21150662 |
| quinone-dependent d-lactate dehydrogenase dld (cg1027) is essential for growth of corynebacterium glutamicum on d-lactate. | corynebacterium glutamicum is able to grow with lactate as sole or combined carbon and energy source. quinone-dependent l-lactate dehydrogenase lldd is known to be essential for utilization of l-lactate by c. glutamicum. d-lactate also serves as sole carbon source for c. glutamicum atcc 13032. | 2010 | 21159175 |
| safety of high doses of propionibacterium freudenreichii et-3 culture in healthy adult subjects. | propionibacterium freudenreichii et-3 (7025) culture, a cell-free product of whey fermentation by p. freudenreichii et-3, has been shown to promote the growth of bifidobacteria through the action of 1,4-dihydroxy-2-naphthoic acid (dhna). here we report the results of two clinical studies designed to evaluate the safety of high doses of p. freudenreichii et-3 culture medium. study 1 had a randomized, double-blind, crossover design. ten healthy male and four healthy female subjects received 45 tab ... | 2010 | 21172397 |
| multilocus sequence typing of propionibacterium freudenreichii. | propionibacterium freudenreichii is used as a ripening culture in swiss cheese manufacture. this study investigates the molecular diversity and the population structure of this bacterium via multilocus sequence typing (mlst). internal fragments of seven genes sequenced for 113 strains of different subspecies and origins allowed the resolution of 46 sequence types (sts) with occurrence frequencies ranging from 1 to 11. the core genome of the species harbours a low level of nucleotide polymorphism ... | 2010 | 21176990 |
| recombinant lactobacilli expressing linoleic acid isomerase can modulate the fatty acid composition of host adipose tissue in mice. | we have previously demonstrated that oral administration of a metabolically active bifidobacterium breve strain, with ability to form cis-9, trans-11 conjugated linoleic acid (cla), resulted in modulation of the fatty acid composition of the host, including significantly elevated concentrations of c9, t11 cla and omega-3 (n-3) fatty acids in liver and adipose tissue. in this study, we investigated whether a recombinant lactobacillus expressing linoleic acid isomerase (responsible for production ... | 2010 | 21178166 |
| synthesis and antimicrobial activity of long-chain 3,4-epoxy-2-alkanones. | 3,4-epoxy-2-dodecanone, a major component in the preorbital gland of the african grey duiker (sylvicapra grimmia), showed antimicrobial activity in preliminary tests. the c(11) to c(17) homologues of this compound were prepared and their activity against several pathogenic dermal bacteria and fungi was tested. 3,4-epoxy-2-dodecanone and 3,4-epoxy-2-tridecanone inhibited the growth of trichophyton mentagrophytes at 25 îg/ml. moderate inhibition of the growth of the bacteria propionibacterium acne ... | 2010 | 21179314 |
| production of 5-aminolevulinic acid by propionibacterium acidipropionici tistr442. | propionibacterium acidipropionici tistr442 produced the highest amount of 5-aminolevulinic acid (ala) when cultivated in medium supplemented with glycine at 18g/l. ala production correlated with ala synthase activity, whereas ala dehydratase activity was maintained at a low level. ala yield reached 405mg/l after prolonged cultivation for 1 month. | 2010 | 21185777 |
| treating acne in women. | | 2010 | 21214119 |
| efficacy of an anaerobic swab transport system to maintain aerobic and anaerobic microorganism viability after storage at -80 degrees c. | an amies agar gel swab transport system was evaluated for its ability to maintain bacterial viability and relative quantity after freezing at -80°c. nine american type culture collection (atcc) bacterial strains were used: 3 anaerobic strains (propionibacterium acnes, peptostreptococcus anaerobius, and clostridium sporogenes) and 6 facultative or strict aerobic bacterial strains (stenotrophomonas maltophilia, escherichia coli ([atcc 25922 and atcc 11775], salmonella enterica subsp. enterica sero ... | 2011 | 21217035 |
| what is the role of benzoyl peroxide cleansers in acne management?: do they decrease propionibacterium acnes counts? do they reduce acne lesions? | | 2008 | 21218192 |
| comparison of the in vivo antimicrobial effectiveness of sodium hypochlorite and chlorhexidine used as root canal irrigants: a molecular microbiology study. | the purpose of this clinical study was to compare the antimicrobial effects of 2.5% sodium hypochlorite (naocl) and 0.12% chlorhexidine digluconate (chx) when used as irrigants during treatment of teeth with apical periodontitis. | 2011 | 21238793 |
| propionobacter acnes infection as an occult cause of postoperative shoulder pain: a case series. | infections after shoulder surgery are potentially devastating complications. propionibacterium acnes is recognized as a causal agent in shoulder infections. the clinical presentation is usually insidious and nonspecific, but a p. acnes infection could be an occult cause of postoperative shoulder pain. | 2011 | 21240577 |
| interactions between various microbes and ginseng botanicals. | three kinds of interactions occur between ginseng botanicals and microorganisms: a) spoilage of the botanical by various fungi (e.g., aspergillus, penicillium, alternaria, and eurotium species) and bacteria; b) transformation of ginsenosides into more bioactive forms by bacteria such as intrasporangium sp. gs603, microbacterium sp. gs514, caulobacter leidyia, bifidobacterium sp. int57, bifidobacterium sp. sj32, fusobacterium sp. and bacteroides sp., and moulds (e.g., aspergillus niger, fusarium ... | 2011 | 21254831 |
| propionibacterium acnes vaccination induces regulatory t cells and th1 immune responses and improves mouse atopic dermatitis. | atopic dermatitis (ad) is a chronic disease characterized by a polarized th2 immune response. propionibacterium acnes (p. acnes) has been shown to elicit strong th1 immune responses. we hypothesized that the host immune response to p. acnes will prevent the development of ad. to demonstrate this hypothesis, we investigated the effect of p. acnes vaccination on ad that occurs in keratin 14/driven caspase-1 transgenic mouse. vaccination with low dose of p. acnes successfully prevented clinical man ... | 2011 | 21255097 |
| new approaches in light/laser therapies and photodynamic treatment of acne. | acne is a domain in which the technology and understanding of light/laser therapeutic procedures have advanced considerably. the aim of the paper was to revisit adjunctive physical treatments of acne, including light/laser treatments and photodynamic therapy. this review summarizes findings about such treatment modalities with particular emphasis on efficacy and safety. a number of laser/light-based modalities have been developed to meet the increasing demand for new acne treatments. the current ... | 2011 | 21269242 |
| efficacy of oral antibiotics on acne vulgaris and their effects on quality of life: a multicenter randomized controlled trial using minocycline, roxithromycin and faropenem. | there are few clinical studies which compare the efficacy and patient satisfaction for oral antibiotics to treat inflammatory acne. to clarify the difference between oral antibiotics, acne patients with moderate to severe inflammatory eruptions were randomized into three groups, and each patient was given minocycline (mino), roxithromycin (rxm) or faropenem (frpm) for 4 weeks, followed by 4 weeks of observation without any oral antibiotics. we estimated the reduction rate of inflammatory lesion ... | 2010 | 21269305 |