| specific medicinal plant polysaccharides effectively enhance the potency of a dc-based vaccine against mouse mammary tumor metastasis. | dendritic cell (dc) vaccines are a newly emerging immunotherapeutic approach for the treatment and prevention of cancer, but major challenges still remain particularly with respect to clinical efficacy. engineering and optimization of adjuvant formulations for dc-based vaccines is one strategy through which more efficacious treatments may be obtained. in this study, we developed a new ex vivo approach for dc vaccine preparation. we evaluated two highly purified mixed polysaccharide fractions fro ... | 2015 | 25825910 |
| effect of astragaloside iv against rat myocardial cell apoptosis induced by oxidative stress via mitochondrial atp-sensitive potassium channels. | astragaloside is one of the most common traditional chinese medicines and is derived from astragalus membranaceus. astragaloside iv (asiv) is a monomer located in an extract of astragaloside. the current study investigated the protective effects of asiv against hydrogen peroxide (h2o2)-induced injury in cardiocytes and elucidated the mechanisms responsible for this protective effect. cultured neonatal rat cardiocytes were divided into five experimental groups as follows: i) dimethyl sulfoxide; i ... | 2015 | 25739067 |
| protective effects of astragaloside iv against ovalbumin-induced lung inflammation are regulated/mediated by t-bet/gata-3. | bronchial asthma is characterized by chronic lung inflammation, airway hyperresponsiveness, and airway remodelling. astragaloside iv (3-o-β-d-xylopyranosyl-6-o-β-d-glucopyranosyl-cycloastragenol, ast), the primary pure saponin isolated from the root of astragalus membranaceus, is an effective compound with distinct pharmacological effects including anti-inflammation, immunoregulation, and antifibrosis. however, the effect of ast on asthma remains unclear. in the present study, in the murine mode ... | 2014 | 25171656 |
| astragaloside iv protects against isoproterenol-induced cardiac hypertrophy by regulating nf-κb/pgc-1α signaling mediated energy biosynthesis. | we previously reported that astragaloside iv (asiv), a major active constituent of astragalus membranaceus (fisch) bge protects against cardiac hypertrophy in rats induced by isoproterenol (iso), however the mechanism underlying the protection remains unknown. dysfunction of cardiac energy biosynthesis contributes to the hypertrophy and nuclear factor κb (nf-κb)/peroxisome proliferator-activated receptor-γ coactivator 1α (pgc-1α) signaling gets involved in the dysfunction. the present study was ... | 2015 | 25738576 |
| biological active ingredients of traditional chinese herb astragalus membranaceus on treatment of diabetes: a systematic review. | diabetes mellitus (dm) is a serious chronic metabolic disease which disease afflicting at present now afflicts approximately 4% of world population worldwide. nowadays, the need for more potent and safe drugs to supply the present anti-diabetic and treated drugs has become an imperative. astragalus membranaceus, the most common chinese herb and key-component of many chinese herbal anti-diabetic formulas, is rich in anti-diabetic compounds: polysaccharides (aps), saponins (ass), and flavonoids (a ... | 2015 | 25723453 |
| astragalus membranaceus injection combined with conventional treatment for viral myocarditis: a systematic review of randomized controlled trials. | to assess the efficacy and safety of astragalus membranaceus injection combined with conventional therapy in the treatment of viral myocarditis. | 2014 | 25098261 |
| cycloastragenol is a potent telomerase activator in neuronal cells: implications for depression management. | cycloastragenol (cag) is an aglycone of astragaloside iv. it was first identified when screening astragalus membranaceus extracts for active ingredients with antiaging properties. the present study demonstrates that cag stimulates telomerase activity and cell proliferation in human neonatal keratinocytes. in particular, cag promotes scratch wound closure of human neonatal keratinocyte monolayers in vitro. the distinct telomerase-activating property of cag prompted evaluation of its potential app ... | 2014 | 25095809 |
| [autotoxicity of aqueous extracts from plant of cultivated astragalus membranaceus var. mongholicus]. | to exploring the relationship between continuous cropping obstacle and autotoxicity of astragalus membranaceus var. mongholicus, autotoxic effect of plant aqueous extract were determined. | 2014 | 25095333 |
| total extract of yupingfeng attenuates bleomycin-induced pulmonary fibrosis in rats. | yupingfeng is a chinese herbal compound used efficaciously to treat respiratory tract diseases. total glucosides of yupingfeng have been proven effective in anti-inflammation and immunoregulation. nevertheless, the role of total extract of yupingfeng (yte) in pulmonary fibrosis (pf), a severe lung disease with no substantial therapies, remains unknown. present study was conducted to elucidate the anti-fibrotic activity of yte. the rat pf model was induced by intratracheal administration of bleom ... | 2015 | 25636879 |
| review of the botanical characteristics, phytochemistry, and pharmacology of astragalus membranaceus (huangqi). | astragalus membranaceus is one of the most widely used traditional chinese herbal medicines. it is used as immune stimulant, tonic, antioxidant, hepatoprotectant, diuretic, antidiabetic, anticancer, and expectorant. the current paper reviews the botanical characteristics, phytochemistry, and pharmacology of astragali radix. information on astragali radix was gathered via the internet (using google scholar, baidu scholar, elsevier, acs, medline plus, cnki, and web of science) as well as from libr ... | 2014 | 25087616 |
| genotoxicity study of polysaccharide fraction from astragalus membranaceus's aerial parts. | radix astragali, the root of astragalus (a.) membranaceus, has been applied in a variety of diseases for a long time in asian countries such as korea and china. in addition, the aerial parts such as leaves and stems of a. membranaceus have received a great deal of attention. recently, the polysaccharide fraction showing a potent immunomoduating activity was isolated from the aerial parts of a. membranaceus. thus, the aerial parts of a. membranaceus would be worthy enough for a food material and ... | 2014 | 25071923 |
| herb-drug interaction between an anti-hiv chinese herbal sh formula and atazanavir in vitro and in vivo. | with the prevalent use of highly active antiretroviral therapy (haart) for aids patients since 1996, the mortality of hiv/aids patients has been remarkably decreased. with long-term use of haart, drug resistance and side effects of antiretrovirals have been frequently reported, which not only reduce the efficacy, but also decreases the tolerance of patients. traditional herbal medicine has become more popular among hiv/aids patients as adjuvant therapy to reduce these adverse effects of haart. s ... | 2015 | 25614104 |
| biochanin a promotes proliferation that involves a feedback loop of microrna-375 and estrogen receptor alpha in breast cancer cells. | biochanin a and formononetin are o-methylated isoflavones that are isolated from the root of astragalus membranaceus, and have antitumorigenic effects. our previous studies found that formononetin triggered growth-inhibitory and apoptotic activities in mcf-7 breast cancer cells. we performed in vivo and in vitro studies to further investigate the potential effect of biochanin a in promoting cell proliferation in estrogen receptor (er)-positive cells, and to elucidate underlying mechanisms. | 2015 | 25613180 |
| astragaloside iv attenuates injury caused by myocardial ischemia/reperfusion in rats via regulation of toll-like receptor 4/nuclear factor-κb signaling pathway. | myocardial ischemia/reperfusion (mi/r) injury, in which inflammatory response and cell apoptosis play a vital role, is frequently encountered in clinical practice. astragaloside iv (asiv), a small molecular saponin of astragalus membranaceus, has been shown to confer protective effects against many cardiovascular diseases. the present study was aimed to investigate the antiinflammatory and antiapoptotic effects and the possible mechanism of asiv on mi/r injury in rats. rats were randomly divided ... | 2015 | 25604645 |
| astragaloside iv controls collagen reduction in photoaging skin by improving transforming growth factor-β/smad signaling suppression and inhibiting matrix metalloproteinase-1. | exposure to ultraviolet (uv) light reduces levels of type i collagen in the dermis and results in human skin damage and premature skin aging (photoaging). this leads to a wrinkled appearance through the inhibition of transforming growth factor‑β (tgf‑β)/smad signaling. uv irradiation increases type i collagen degradation through upregulating matrix metalloproteinase (mmp) expression. astragaloside iv (ast) is one of the major active components extracted from astragalus membranaceus. however, its ... | 2015 | 25591734 |
| efficient production of isoflavonoids by astragalus membranaceus hairy root cultures and evaluation of antioxidant activities of extracts. | in this study, astragalus membranaceus hairy root cultures (amhrcs) were established as an attractive alternative source for the efficient production of isoflavonoids (if). a. membranaceus hairy root line ii was screened as the most efficient line and was confirmed by pcr amplification of rolb, rolc and aux1 genes. culture parameters of amhrcs were systematically optimized, and five main if constituents were quali-quantitatively determined by lc-ms/ms. under optimal conditions, the total if accu ... | 2014 | 25483292 |
| the combination of astragalus membranaceus and ligustrazine ameliorates micro-haemorrhage by maintaining blood-brain barrier integrity in cerebrally ischaemic rats. | haemorrhagic transformation is an asymptomatic event that frequently occurs after following ischaemic stroke, particularly when pharmaceutical thrombolysis is used. however, the mechanism responsible for haemorrhagic transformation remains unknown, and therapeutics have not been identified. in this study, we administered a combination of astragalus membranaceus and ligustrazine to rats with cerebral ischaemia that had undergone thrombolysis. we analysed the effect of this combination on the atte ... | 2014 | 25456435 |
| astragalus polysaccharide inhibits isoprenaline-induced cardiac hypertrophy via suppressing ca²⁺-mediated calcineurin/nfatc3 and camkii signaling cascades. | pathological cardiac hypertrophy induced by increased sympathetic drive can subsequently lead to congestive heart failure, which represents the major cause of morbidity and mortality worldwide. astragalus polysaccharide (aps) is an active compound extracted from chinese herb astragalus membranaceus (am), a frequently used "qi-invigorating" herbal medicine in traditional medicine broadly used for the treatment of cardiovascular and other diseases. currently, little is known about the effect of ap ... | 2014 | 24975447 |
| astragalus membranaceus up-regulate cosmc expression and reverse iga dys-glycosylation in iga nephropathy. | decreased core i β3-gal-t-specific molecular chaperone (cosmc) expression induced iga1 aberrant glycosylation is the main characteristic of iga nephropathy (igan). this study tried to elucidate the effect of astragalus membranaceus on cosmc expression and iga o-glycosylation of peripheral b lymphocytes in igan patients. | 2014 | 24942185 |
| myelo-enhancement by astragalus membranaceus in male albino rats with chemotherapy myelo-suppression. histological and immunohistochemical study. | myelosuppression is the most common toxicity encountered in the oncology clinic today. this study was planned to investigate the possible protective and therapeutic role of the traditional chinese medicinal herb; astragalus membranaceus (am), on chemotherapy-induced myelosuppression. | 2014 | 24921023 |
| polysaccharides from angelica and astragalus exert hepatoprotective effects against carbon-tetrachloride-induced intoxication in mice. | this study aimed to investigate the effects of polysaccharide from angelica and astragalus (aap) on carbon tetrachloride (ccl4) induced liver damage in mice. a total of 120 kunming mice were randomly distributed among 6 groups comprising (i) the normal control mice, (ii) the ccl4 treatment group, (iii) the bifendate treatment group, (iv) the aap treatment group, (v) the angelica sinensis polysaccharide (asp) treatment group, and (vi) the astragalus membranaceus polysaccharide (amp) treatment gro ... | 2015 | 25415237 |
| profiling the metabolism of astragaloside iv by ultra performance liquid chromatography coupled with quadrupole/time-of-flight mass spectrometry. | astragaloside iv is a compound isolated from the traditional chinese medicine astragalus membranaceus, that has been reported to have bioactivities against cardiovascular disease and kidney disease. there is limited information on the metabolism of astragaloside iv, which impedes comprehension of its biological actions and pharmacology. in the present study, an ultra-performance liquid chromatography coupled with quadrupole/time-of-flight mass spectrometry (uplc-q-tof-ms/ms)-based approach was d ... | 2014 | 25407723 |
| astragalus polysaccharide suppresses doxorubicin-induced cardiotoxicity by regulating the pi3k/akt and p38mapk pathways. | doxorubicin, a potent chemotherapeutic agent, is associated with acute and chronic cardiotoxicity, which is cumulatively dose-dependent. astragalus polysaccharide (aps), the extract of astragalus membranaceus with strong antitumor and antiglomerulonephritis activity, can effectively alleviate inflammation. however, whether aps could ameliorate chemotherapy-induced cardiotoxicity is not understood. here, we investigated the protective effects of aps on doxorubicin-induced cardiotoxicity and eluci ... | 2014 | 25386226 |
| induction of angiogenesis in zebrafish embryos and proliferation of endothelial cells by an active fraction isolated from the root of astragalus membranaceus using bioassay-guided fractionation. | the objective of the study was to identify the active fraction(s) from ar aqueous extract responsible for promoting angiogenesis using bioassay-guided fractionation. the angiogenic activity was screened by monitoring the increase of sprout number in sub-intestinal vessel (siv) of the transgenic zebrafish embryos after they were treated with 0.06-0.25 mg/ml of ar aqueous extract or its fraction(s) for 96 h. furthermore, the angiogenic effect was evaluated in treated zebrafish embryos by measuring ... | 2014 | 25379465 |
| identification of angelica oil as a suppressor for the biological properties of danggui buxue tang: a chinese herbal decoction composes of astragali radix and angelica sinensis radix. | danggui buxue tang (dbt), a chinese herbal decoction commonly used in treating women׳s ailments, contains two herbs: angelica sinensis radix (asr) and astragali radix (ar). traditionally, asr had to be pre-treated with yellow wine before the herbal preparation, which reduced the amount of volatile oil in water extract of asr and dbt, and meanwhile the volatile oil-reduced dbt processed better bioactivities in cell cultures. the present study aimed to investigate the effect of volatile oil from a ... | 2014 | 24837305 |
| [study on method and its optimization of improving seed germination of astragalus membranaceus as gansu traditional medicinal herb]. | to break the hard testa and improve seed germination situation of astragalus membranaceus var. mongholicus, in order to solve the problems of low success rate of seed germination and seedling. | 2014 | 25345121 |
| identifying roles of "jun-chen-zuo-shi" component herbs of qishenyiqi formula in treating acute myocardial ischemia by network pharmacology. | the role of "jun-chen-zuo-shi" (also known as "sovereign-minister-assistant-courier") component herbs of chinese medicine is not fully understood. this study aims to test the "jun-chen-zuo-shi" rule with the qishenyiqi formula (qsyq) on treating acute myocardial ischemia (ami) by a network pharmacology approach. | 2014 | 25342960 |
| astragalus (a traditional chinese medicine) for treating chronic kidney disease. | astragalus (radix astragali, huang qi) is the dried root of astragalus membranaceus (fisch.) bge. var. mongholicus (bge.) hsiao or astragalus membranaceus (fisch.) bge. (family leguminosae). it is one of the most widely used herbs in traditional chinese medicine for treating kidney diseases. evidence is needed to help clinicians and patients make judgments about its use for managing chronic kidney disease (ckd). | 2014 | 25335553 |
| astragalus membranaceus as a cause of increased ca19-9 and liver and kidney cysts: a case report. | astragalus membranaceus, one of the most common chinese herbs, is widely used to prevent and treat a variety of diseases. very few adverse reactions, caused by a. membranaceus, have been reported in the literature. the purpose of this article was to report a case of marked increase in carbohydrate antigen 19-9 (ca19-9) and the formation of liver and kidney cysts following oral administration of a. membranaceus. | 2014 | 24806627 |
| molecular signalings in keloid disease and current therapeutic approaches from natural based compounds. | keloid is an excessive dermal scar occurring in response to skin injuries. several therapeutic strategies have been proposed to ease the aggressiveness of keloid scarring. even though the principle mechanism underlying the disease propagation still remains unidentified, several signaling pathways were highly focused as plausible pathways involving keloid formation, including transforming growth factor-beta 1 (tgf-β1), mitogen-activated protein kinase (mapk), insulin-like growth factor-i (igf-i), ... | 2015 | 25331681 |
| astragalus saponins modulates colon cancer development by regulating calpain-mediated glucose-regulated protein expression. | glucose-regulated proteins (grp) are induced in the cancer microenvironment to promote tumor survival, metastasis and drug resistance. ast was obtained from the medicinal plant astragalus membranaceus, which possesses anti-tumor and pro-apoptotic properties in colon cancer cells and tumor xenograft. the present study aimed to investigate the involvement of grp in endoplasmic reticulum (er) stress-mediated apoptosis during colon cancer development, with focus on the correlation between ast-evoked ... | 2014 | 25319833 |
| formononetin promotes cell cycle arrest via downregulation of akt/cyclin d1/cdk4 in human prostate cancer cells. | formononetin is an o-methylated isoflavone isolated from the root of astragalus membranaceus. it has already been reported that formononetin could inhibit cell proliferation and induce cell apoptosis in several cancers, including prostate cancer. this study aimed to further investigate whether cell cycle arrest is involved in formononetin-mediated antitumor effect in human prostate cancer cells, along with the underlying molecular mechanism. | 2014 | 25301361 |
| anti-stress effect of astragaloside iv in immobilized mice. | astragaloside iv, a major component extracted from the roots of astragalus membranaceus (am), possesses anti-inflammatory, anti-oxidative, anti-fibrotic, anti-infarction and immunoregulatory effects. to clarify anti-stress effect of am, anxiolytic and anti-inflammatory effects of 80% ethanol extract of am and astragaloside iv were investigated in immobilization stress model. | 2014 | 24709311 |
| beneficial effects of astragaloside iv for hair loss via inhibition of fas/fas l-mediated apoptotic signaling. | apoptosis with premature termination of hair follicle growth induces several types of hair loss and is one of the crucial factors of hair loss. astragaloside iv, which is a major component of astragalus membranaceus, is a cycloartane triterpene saponin. although an anti-apoptotic effect of astragaloside iv has been reported, its effects against hair loss have not been investigated. to explore the underlying mechanisms of astragaloside iv on apoptotic signaling in hair follicle, the dorsal skin o ... | 2014 | 24676213 |
| effect of astragalus membranaceus extract on diabetic nephropathy. | diabetic nephropathy, a microvascular complication of diabetes, is a progressive kidney disease caused by angiopathy of the capillaries in the kidney glomeruli. herein, we report a case of a 62-year-old patient with a 30 year history of diabetes, who showed a substantial improvement in diabetic nephropathy on administration of 30 g of astragalus membranaceus extract per day. after 1 month, estimated glomerular filtration rate increased from 47 to 72 ml/min per 1.73 m(2) and was subsequently main ... | 2014 | 25298884 |
| astragalus membranaceus improves exercise performance and ameliorates exercise-induced fatigue in trained mice. | astragalus membranaceus (am) is a popular "qi-tonifying" herb with a long history of use as a traditional chinese medicine with multiple biological functions. however, evidence for the effects of am on exercise performance and physical fatigue is limited. we evaluated the potential beneficial effects of am on ergogenic and anti-fatigue functions following physiological challenge. male icr strain mice were randomly assigned to four groups (n = 10 per group) for treatment: (1) sedentary control an ... | 2014 | 24595275 |
| astragalus membranaceus modulates th1/2 immune balance and activates pparγ in a murine asthma model. | astragalus membranaceus, a traditional chinese herb, has been used to improve airway inflammation and asthma. the present study investigated whether a. membranaceus has immunotherapeutic effects on asthma, a chronic inflammatory mucosal disease that is associated with excess production of ige, eosinophilia, t helper 2 (th2) cytokines, and bronchial hyperresponsiveness. an ovalbumin (ova)-induced, chronic inflammatory airway murine asthma model was used to examine the status of pulmonary inflamma ... | 2014 | 25264079 |
| qu feng xuan bi formula attenuates anaphylactic rhinitis-asthma symptoms via reducing eos count and regulating t cell function in rat ara models. | aqueous extract of qu feng xuan bi formula (qfxbf, a chinese herb formula) which composed of radix glycyrrhizae, radix glycyrrhizae preparata, paeonia sterniana fletcher in journ, pheretima, allium macrostemon bunge, astragalus membranaceus (fisch) bunge and divaricate saposhnikovia root has been used in treatment of allergic rhinitis and asthma (ara) as an approved hospital prescription for many years in jiangsu province hospital of traditional chinese medicine, china. the present study was des ... | 2014 | 24548751 |
| nonsteroidal anti-inflammatory drug activated gene-1 (nag-1) modulators from natural products as anti-cancer agents. | natural products are rich sources of gene modulators that may be useful in prevention and treatment of cancer. recently, nonsteroidal anti-inflammatory drug (nsaid) activated gene-1 (nag-1) has been focused as a target of action against diverse cancers like colorectal, pancreatic, prostate, and breast. a variety of natural agents have been reported to play a pivotal role in regulation of nag-1 through multiple transcriptional mechanisms. the aim of this paper is to review the nag-1 modulators de ... | 2014 | 24530873 |
| the standardized bhh10 extract, a combination of astragalus membranaceus, cinnamomum cassia, and phellodendron amurense, reverses bone mass and metabolism in a rat model of postmenopausal osteoporosis. | jasin-hwan-gagambang (bhh10), a modified prescription of jasin-hwan, contains astragalus membranaceus, cinnamomum cassia, and phellodendron amurense, and it has been traditionally used to treat osteoporosis and other inflammatory diseases. in this study, we systematically investigated the protective effects of bhh10 in ovariectomy (ovx)-induced rats. sprague-dawley rats were randomly divided into sham and ovx subgroups. the rats in the ovx group were treated with vehicle, bhh10, alendronate (aln ... | 2015 | 25230217 |
| the mechanism of astragaloside iv promoting sciatic nerve regeneration. | 3-o-beta-d-xylopyranosyl-6-o-beta-d-glucopyranosyl-cycloastragenol (astragaloside iv), the main active component of the traditional chinese medicine astragalus membranaceus, has been shown to be neuroprotective. this study investigated whether astragaloside iv could promote the repair of injured sciatic nerve. denervated sciatic nerve of mice was subjected to anastomosis. the mice were intraperitoneally injected with 10, 5, 2.5 mg/kg astragaloside iv per day for 8 consecutive days. western blot ... | 2013 | 25206535 |
| astragaloside iv inhibits platelet-derived growth factor-bb-stimulated proliferation and migration of vascular smooth muscle cells via the inhibition of p38 mapk signaling. | astragaloside iv (as-iv), the major active component extracted from astragalus membranaceus, has been demonstrated to exhibit protective effects on the cardiovascular, immune, digestive and nervous systems; thus, has been widely used in traditional chinese medicine. abnormal proliferation and migration of vascular smooth muscle cells (vsmcs) is closely associated with the initiation and progression of cardiovascular diseases, including atherosclerosis and restenosis. however, the effects of as-i ... | 2014 | 25187834 |
| astragaloside iv alleviates early brain injury following experimental subarachnoid hemorrhage in rats. | astragaloside iv, one of the main effective components isolated from astragalus membranaceus, has multiple neuroprotective properties, while the effects of astragaloside iv on the attenuation of subarachnoid hemorrhage (sah)-induced early brain injury (ebi) and its possible mechanisms are unknown. in the present study, we aimed to determine whether astragaloside iv could inhibit oxidative stress, reduce neuronal apoptosis, and improve neurological deficits after experimental sah in rats. rats (n ... | 2014 | 25136262 |
| astragaloside iv attenuates inflammatory cytokines by inhibiting tlr4/nf-кb signaling pathway in isoproterenol-induced myocardial hypertrophy. | astragaloside iv (as iv) is one of the main effective components isolated from the traditional chinese medical herb astragalus membranaceus. the protective effect of astragalus membranaceus on myocardial hypertrophy has been extensively proved. to test the hypothesis that astragaloside iv can ameliorate the myocardial hypertrophy and inflammatory effect induced by β-adrenergic hyperactivity, we carried out in vivo and in vitro experiments. | 2013 | 24432369 |
| effect of astragalus polysaccharides on expression of tnf-α, il-1β and nfatc4 in a rat model of experimental colitis. | astragalus membranaceus is a chinese medicinal herb and has been shown to improve hapten-induced experimental colitis. one of its major components is polysaccharides. we investigated the effect of astragalus polysaccharides (aps) on expression of tnf-α, il-1β and nfatc4 in a rat model of experimental colitis. | 2014 | 25132256 |
| accumulation of astragalosides and related gene expression in different organs of astragalus membranaceus bge. var mongholicus (bge.). | astragalus membranaceus is one of the most important traditional korean and chinese medicinal herbs because it contains triterpenoid saponins (astragaloside i, ii, iii, and iv), which have beneficial and pharmacological effects on health. in this study, we analyzed 10 mevalonate pathway genes that are involved in astragaloside biosynthesis using the illumina/solexa hiseq2000 platform. we determined the expression levels of the 10 genes using quantitative real-time pcr, and analyzed the accumulat ... | 2014 | 25068786 |
| recent advances in astragalus membranaceus anti-diabetic research: pharmacological effects of its phytochemical constituents. | the disease burden of diabetes mellitus is increasing throughout the world. the need for more potent drugs to complement the present anti-diabetic drugs has become an imperative. astragalus membranaceus, a key component of most chinese herbal anti-diabetic formulas, has been an important prospect for lead anti-diabetic compounds. it has been progressively studied for its anti-diabetic properties. ethnopharmacological studies have established its potential to alleviate diabetes mellitus. recent s ... | 2013 | 24348714 |
| astragalus membranaceus inhibits peritoneal fibrosis via monocyte chemoattractant protein (mcp)-1 and the transforming growth factor-β1 (tgf-β1) pathway in rats submitted to peritoneal dialysis. | inflammation and transforming growth factor-β1 (tgf-β1) contribute to the development of peritoneal fibrosis (pf), which is associated with peritoneal dialysis (pd). astragalus membranaceus (astragalus) has anti-inflammatory and anti-fibrotic effects in many diseases. the goal of this study was to determine the anti-fibrotic effects of astragalus on the pf response to pd. a rat model of pd was induced using standard pd fluid, and pf was verified by he and masson's staining, as well as through th ... | 2014 | 25054320 |
| optimization of enzyme assisted extraction of polysaccharides from astragalus membranaceus. | astragalus polysaccharide (aps) is known to have a variety of pharmacological activities. in the present study, enzyme assisted extraction of aps from astragalus mongholicus using various enzymes were examined. research found that glucose oxidase offered a better performance in enhancement of extraction yields of aps than other ones. glucose oxidase assisted extraction process was further optimized by using response surface method (rsm) to obtain maximum yield of crude aps. the optimized extract ... | 2014 | 25037388 |
| astragaloside iv inhibits progression of lung cancer by mediating immune function of tregs and ctls by interfering with ido. | tumor cells have developed multiple mechanisms to escape immune recognition mediated by t cells. indoleamine 2,3-dioxygenase (ido), a tryptophan-catabolizing enzyme inducing immune tolerance, is involved in tumor escape from host immune systems in mice. astragaloside iv (as-iv), an extract from a commonly used chinese medicinal plant astragalus membranaceus, has been shown to be capable of restoring the impaired t-cell functions in cancer patients. the purpose of this study was to investigate th ... | 2014 | 24980548 |
| formononetin inhibits migration and invasion of mda-mb-231 and 4t1 breast cancer cells by suppressing mmp-2 and mmp-9 through pi3k/akt signaling pathways. | formononetin is a naturally existing isoflavone, which can be found in the roots of astragalus membranaceus, trifolium pratense, glycyrrhiza glabra, and pueraria lobata. it was found to be associated with inhibition of cell proliferation and cell cycle progression, as well as induction of apoptosis in various cancer cell lines. however, the effect of formononetin on breast cancer cell metastasis remains unclear. in this study, we examined the effect of formononetin on the migration and invasion ... | 2014 | 24977660 |
| herbal extract sh003 suppresses tumor growth and metastasis of mda-mb-231 breast cancer cells by inhibiting stat3-il-6 signaling. | cancer inflammation promotes cancer progression, resulting in a high risk of cancer. here, we demonstrate that our new herbal extract, sh003, suppresses both tumor growth and metastasis of mda-mb-231 breast cancer cells via inhibiting stat3-il-6 signaling path. our new herbal formula, sh003, mixed extract from astragalus membranaceus, angelica gigas, and trichosanthes kirilowii maximowicz, suppressed mda-mb-231 tumor growth and lung metastasis in vivo and reduced the viability and metastatic abi ... | 2014 | 24976685 |
| chemical composition and synergistic antioxidant activities of essential oils from atractylodes macrocephala and astragalus membranaceus. | chemical composition of the essential oils derived from atractylodes macrocephala (ama), astragalus membranaceus (ame) and ama-ame herb pair was investigated using gas chromatography-mass spectrometry (gc-ms). antioxidant activities were evaluated by 1,1-diphenyl-2-picyrlhydrazyl (dpph) radical-scavenging and trolox equivalent antioxidant capacity (teac) assays. forty-five, ten and forty-three components were identified in ama, ame and ama-ame essential oils, respectively. ama-ame essential oil ... | 2013 | 24273876 |
| protective effects of astragaloside iv against amyloid beta1-42 neurotoxicity by inhibiting the mitochondrial permeability transition pore opening. | mitochondrial dysfunction caused by amyloid β-peptide (aβ) plays an important role in the pathogenesis of alzheimer disease (ad). substantial evidence has indicated that the mitochondrial permeability transition pore (mptp) opening is involved in aβ-induced neuronal death and reactive oxygen species (ros) generation. astragaloside iv (as-iv), one of the major active constituents of astragalus membranaceus, has been reported as an effective anti-oxidant for treating neurodegenerative diseases. ho ... | 2014 | 24905226 |
| accumulation of flavonoids and related gene expressions in different organs of astragalus membranaceus bge. | astragalus membranaceus is one of the important medicinal plant in china and korea. it is used to increase metabolism and digestion, enhance the immune system, and promote the healing of wounds and injuries. in the present study, we used quantitative real-time pcr to investigate the expression of genes related to the biosynthesis of flavonoids, in addition to high-performance liquid chromatography to assess calycosin and calycosin-7-o-β-d-glucoside accumulation, in the different plant organs of ... | 2014 | 24903957 |
| effect of ht042, herbal formula, on longitudinal bone growth in spontaneous dwarf rats. | ht042 is a new herbal prescription consisting of astragalus membranaceus, phlomis umbrosa and eleutherococcus senticosus, which are used in korean medicine to stimulate growth in children. we investigated the effects of ht042 on the body weight, longitudinal bone growth, and bone length in spontaneous dwarf rats (sdr). male and female sdrs were divided into three groups: the control group (dw, 10 ml/kg/day), the recombinant human gh group (rhgh; 500 µg/kg/day), and the ht042 (100 mg/kg/day) grou ... | 2013 | 24169467 |
| selenium-dependent antitumor immunomodulating activity of polysaccharides from roots of a. membranaceus. | roots of astragalus membranaceus (fish.) bge. var. mongholicus (bge.) hsiao (a. membranaceus) have been long used as an auxiliary reagent supporting cancer treatment. here, we compared the chemical composition and antitumor immunomodulating activity of polysaccharides from roots of a. membranaceus (pams) from five major habitats in inner mongolia, pr china. we revealed that compositions of monosaccharides and amino acids were comparable among pams from different habitats. however, amounts of sel ... | 2014 | 24857867 |
| an integrated analysis for determining the geographical origin of medicinal herbs using icp-aes/icp-ms and (1)h nmr analysis. | icp-ms and (1)h nmr are commonly used to determine the geographical origin of food and crops. in this study, data from multielemental analysis performed by icp-aes/icp-ms and metabolomic data obtained from (1)h nmr were integrated to improve the reliability of determining the geographical origin of medicinal herbs. astragalus membranaceus and paeonia albiflora with different origins in korea and china were analysed by (1)h nmr and icp-aes/icp-ms, and an integrated multivariate analysis was perfo ... | 2014 | 24837936 |
| astragaloside iv stimulates angiogenesis and increases nitric oxide accumulation via jak2/stat3 and erk1/2 pathway. | astragaloside iv (as-iv), one of the major active constituents of astragalus membranaceus in traditional chinese medicine, has been widely used to treat ischemic diseases. however, the potential mechanism is this action is unclear. in this study, we tested the hypothesis that as-iv might promote angiogenesis through multiple signaling pathways. our data indicate that as-iv treatment promotes umbilical vein endothelial cells (huvec) proliferation, migration, and tube formation. as-iv treatment al ... | 2013 | 24135938 |
| high-throughput analysis and characterization of astragalus membranaceus transcriptome using 454 gs flx. | astragalus membranaceus (fisch.) bge (ar), one of the most important medicinal plants in asia, was found to exhibit various bioactivities. due to limited genomic and transcriptomic data, the biosynthetic pathway of the major bioactive compound in ar, is currently unclear. in this study, 454 gs flx technology was employed to produce a substantial expressed sequence tag (est) dataset from the ar. in all, 742721 high-quality reads from the ar were produced using roche gs flx titanium. a total of 98 ... | 2014 | 24828103 |
| a network pharmacology study of chinese medicine qishenyiqi to reveal its underlying multi-compound, multi-target, multi-pathway mode of action. | chinese medicine is a complex system guided by traditional chinese medicine (tcm) theories, which has proven to be especially effective in treating chronic and complex diseases. however, the underlying modes of action (moa) are not always systematically investigated. herein, a systematic study was designed to elucidate the multi-compound, multi-target and multi-pathway moa of a chinese medicine, qishenyiqi (qsyq), on myocardial infarction. qsyq is composed of astragalus membranaceus (huangqi), s ... | 2014 | 24817581 |
| in vitro synergistic antioxidant activity and identification of antioxidant components from astragalus membranaceus and paeonia lactiflora. | many traditionally used herbs demonstrate significantly better pharmacological effects when used in combination than when used alone. however, the mechanism underlying this synergism is still poorly understood. this study aimed to investigate the synergistic antioxidant activity of astragalus membranaceus (ame) and paeonia lactiflora (pl), and identify the potential antioxidant components by 1,1-diphenyl-2-picrylhydrazine (dpph) radical spiking test followed by a high performance liquid chromato ... | 2014 | 24816851 |
| astragalus saponin attenuates the expression of fibrosis-related molecules in irradiated cardiac fibroblasts. | the main pathological change of radiation-induced heart disease is fibrosis. emerging evidence has indicated that astragalus membranaceus and its extractant, astragalus saponin (ast), were used for treating fibrosis diseases. in the present study, the effects of ast on fibrosis damage induced by irradiation were determined. after being irradiated with 1 or 2-gy x-rays, obvious changes of endoplasmic reticulum morphology were observed in cardiac fibroblasts (cfs), suggesting that its protein proc ... | 2014 | 24739634 |
| antitumor and immunomodulatory activity of astragalus membranaceus polysaccharides in h22 tumor-bearing mice. | in the present study, we investigated the antitumor and immunomodulatory activity of astragalus membranaceus polysaccharide (amp) on liver cancer using murine h22 hepatocarcinoma model. the results showed that amp (100 and 400 mg/kg) could effectively inhibit the solid tumor growth of h22 hepatocarcinoma transplanted in balb/c mice. besides, the body weight, spleen/thymus indexes and phagocytotic function of macrophage of h22 tumor bearing mice were also improved in two amp treated groups. furth ... | 2013 | 24060282 |
| a chinese 2-herb formula (nf3) promotes hindlimb ischemia-induced neovascularization and wound healing of diabetic rats. | diabetic foot ulcer is closely associated with peripheral vascular disease. enhancement of tissue oxidative stress, reduction of nitric oxide (no) and angiogenic growth factors, and abnormal matrix metalloproteinase (mmp) activity are pathophysiological factors in post-ischemic neovascularization and diabetic wound healing. our previous study demonstrated that the chinese 2-herb formula, nf3, showed significant wound healing effects on diabetic foot ulcer rats. a novel rat diabetic foot ulcer wi ... | 2016 | 24731763 |
| a standardized extract from paeonia lactiflora and astragalus membranaceus induces apoptosis and inhibits the proliferation, migration and invasion of human hepatoma cell lines. | paeonia lactiflora and astragalus membranaceus are two traditional chinese medicines, which are commonly used in chinese herb prescription to treat liver diseases. the protective effects of the extract prepared from the roots of paeonia lactiflora and astragalus membranaceus (pae) on liver fibrosis have been demonstrated in previous studies. however, its effect on hepatocellular carcinoma (hcc) has not been investigated to date. in this study, the effects of pae on the apoptosis, proliferation, ... | 2013 | 24002667 |
| herbal medicines for viral myocarditis. | herbal medicines are used as treatment for viral diseases such as viral myocarditis, and numerous clinical trials have been conducted to investigate their efficacy. despite this wealth of evidence, the role of herbal medicines in the treatment of viral myocarditis has yet to be established. this is an update of a review published in 2012. | 2013 | 23986406 |
| antihepatoma and liver protective potentials of ganoderma lucidum ( ling zhi) fermented in a medium containing black soybean ( hēi dòu) and astragalus membranaceus ( shēng huáng qí). | the antihepatoma activity and liver protective function of the fermentation products (5 l fermenator) of ganoderma lucidum (gl; ling zhi) cultivated in a medium containing black soybean (bs; hēi dòu) and astragalus membranaceus (am; shēng huáng qí) at different fermentation temperatures were investigated in this study. hep 3b cells pretreated with lovastatin were used to study the antihepatoma activity, and possible active components were analyzed by reverse-phase high-performance liquid chromat ... | 2013 | 24716165 |
| oral chinese herbal medicine combined with pharmacotherapy for stable copd: a systematic review of effect on bode index and six minute walk test. | this systematic review evaluated the effects of chinese herbal medicine (chm) plus routine pharmacotherapy (rp) on the objective outcome measures bode index, 6-minute walk test (6mwt), and 6-minute walk distance (6mwd) in individuals with stable chronic obstructive pulmonary disease (copd). searches were conducted of six english and chinese databases (pubmed, embase, central, cinahl, cnki and cqvip) from their inceptions until 18th november 2013 for randomized controlled trials involving oral ad ... | 2014 | 24622390 |
| the in vivo and in vitro study of polysaccharides from a two-herb formula on ulcerative colitis and potential mechanism of action. | lycium barbarum and astragalus membranaceus are two traditional medicinal herbs widely used in china for nourishing yin and reinforcing qi. the purpose of the study was to investigate the prophylactic and curative effects of crude polysaccharides (qhps) extracted from a two-herb formula composed of lycium barbarum and astragalus membranaceus at a ratio of 2:3 in colitis rats, and to further elucidate the potential mechanism of action in epithelial cell proliferation in vitro. | 2014 | 24548752 |
| astragaloside iv attenuates inflammatory cytokines by inhibiting tlr4/nf-кb signaling pathway in isoproterenol-induced myocardial hypertrophy. | astragaloside iv(as iv) is one of the main effective components isolated from the traditional chinese medical herb astragalus membranaceus. the protective effect of astragalus membranaceus on myocardial hypertrophy has been extensively proved. to test the hypothesis that astragaloside iv can ameliorate the myocardial hypertrophy and inflammatory effect induced by β-adrenergic hyperactivity, we carried out in vivo and in vitro experiments. | 2013 | 24513635 |
| astragaloside iv possesses antiarthritic effect by preventing interleukin 1β-induced joint inflammation and cartilage damage. | the saponin astragaloside iv (ast) is one of major active components purified from astragalus membranaceus (fisch) bge, which has been used in traditional chinese medicine to treat immune disorders including rheumatoid arthritis (ra). the effects of ast on the suppression of experimental arthritis and its possible mechanisms are unknown. we measured the paw swelling of ankle joints, splenocyte proliferation, interleukin 1β (il-1β), tumor necrosis factor α (tnfα) and nitric oxide (no) formation b ... | 2014 | 24469603 |
| pharmacokinetic interaction of astragaloside iv with atractylenolide i and prim-o-glucosylcimifugin in male sprague dawley rats. | astragaloside iv, atractylenolide i, and prim-o-glucosylcimifugin are main medicinal components of the traditional chinese medicine prescription yu-ping-feng which is composed of three herbs: astragalus membranaceus, atractylodes macrocephala, and saposhnikovia divaricata. this study is aimed to assess the influence of atractylenolide i and prim-o-glucosylcimifugin on the pharmacokinetic profile of astragaloside iv so as to investigate the pharmacokinetic mechanisms of the yu-ping-feng prescript ... | 2014 | 24452462 |
| [treatment of severe active systemic lupus erythematosus by pmc therapy combined langchuang fuzheng jiedu capsule: a clinical observation]. | to evaluate the efficacy and safety of pmc therapy (prednisone, methotrexate, chloroquine) combined langchuang fuzheng jiedu capsule (lfjc), thus choosing a better therapy of integrative medicine for sle in the period of glucocorticoid use. | 2013 | 24432670 |
| effects of traditional chinese medicinal plants on anti-insulin resistance bioactivity of dxms-induced insulin resistant hepg2 cells. | medicinal plants have a long history of use in china to treat diabetic symptoms. ancient chinese medical manuscripts and ethnobotanical surveys document plant remedies that continue to be actively used in china for the treatment of diabetic symptoms. based on a systematic ancient chinese medical manuscripts review in combination with ethnobotanical survey, 16 medicinal plants for the traditional treatment of diabetic symptoms were identified for the evaluation of anti-insulin resistance bioactiv ... | 2014 | 25089237 |
| folfox 4 combined with herbal medicine for advanced colorectal cancer: a systematic review. | this systematic review evaluates the clinical evidence for the addition of herbal medicines (hms) to folfox 4 for advanced colorectal cancer (acrc) in terms of tumor response rate (trr), survival, quality of life and reduction in adverse events (aes). seven electronic databases were searched for randomized controlled trials (rcts) of folfox4 combined with hms compared to folfox4 alone. outcome data for 13 randomized controlled trials were analysed using review manager 5.1. risk of bias for objec ... | 2014 | 24343974 |
| effect of the combinatory mixture of rubus coreanus miquel and astragalus membranaceus bunge extracts on ovariectomy-induced osteoporosis in mice and anti-rank signaling effect. | postmenopausal osteoporosis is one of the most common disorders in women after menopause, which is linked to an estrogen deficiency and characterized by an excessive loss of trabecular bone. rubus coreanus and astragalus membranaceus have been used for their various pharmacological properties in asia as a traditional medicine. the present study evaluated the anti-osteoporotic effects of the optimal combination of rubus coreanus and astragalus membranaceus in 7:3 mixture (ram) in ovariectomized ( ... | 2014 | 24333364 |
| compound astragalus and salvia miltiorrhiza extracts suppress hepatocarcinogenesis by modulating transforming growth factor-β/smad signaling. | previous studies showed compound astragalus and salvia miltiorrhiza extract (case), extract from astragalus membranaceus and salvia miltiorhiza, significantly suppresses hepatocellular carcinoma (hcc) in rats induced by diethylinitrosamine (den), and in vitro experiments further demonstrated that case's anti-hepg2 cell invasion is associated with transforming growth factor-β (tgf-β). we hypothesized that case's suppression of hcc is modulated by tgf-β/smad signaling, and we conducted this in viv ... | 2014 | 24329763 |
| structural features and biological activities of the polysaccharides from astragalus membranaceus. | recently, a great deal of interest has been developed to isolate and investigate novel bioactive components with health benefit effects from natural resources. the dried root of astragalus membranaceus, one of the most popular health-promoting herbal medicines, has been used historically as an immunomodulating agent for the treatment of common cold, diarrhea, fatigue and anorexia for more than 2000 years. modern phytochemistry and pharmacological experiments have proved that polysaccharide is on ... | 2014 | 24325861 |
| a refined-jinqi-jiangtang tablet ameliorates prediabetes by reducing insulin resistance and improving beta cell function in mice. | refined-jq (jq-r) is a mixture of refined extracts from three major herbal components of jinqi-jiangtang tablet: coptis chinensis (ranunculaceae), astragalus membranaceus (leguminosae), and lonicera japonica (caprifoliaceae). our previous studies have indicated that jq-r could decrease fasting blood glucose levels in diabetic mice and insulin resistance mice. investigating the hypoglycemic effect of jq-r on prediabetes has practical application value for preventing or delaying insulin resistance ... | 2014 | 24286962 |
| in vitro and in vivo anti-cancer activity of formononetin on human cervical cancer cell line hela. | worldwide, cervical cancer (cc) is the third most common malignancy in women, and it remains a leading cause of cancer-related death of women. genomic studies indicate that phosphoinositide 3-kinase (pi3k)/akt signaling is one of the most frequently deregulated pathways in several human cancers, including cc. this signaling pathway has an important role in cancer cell proliferation, survival, motility, and metabolism, and therefore could be an attractive therapeutic target. in a previous study, ... | 2014 | 24272199 |
| anti-inflammatory cycloartane-type saponins of astragalus membranaceus. | a new cycloartane-type triterpene glycoside, agroastragaloside v (1) was isolated from the roots of astragalus membranaceus. the structure was identified as 3-o-β-(2'-o-acetyl)-d-xylopyranosyl-6-o-β-d-glucopyranosyl-(24s)-3β,6α,24α,25-tetrahydroxy- 9,19-cyclolanostane, by means of spectroscopic methods, including hr-fab/ms, 1d nmr (1h, 13c, dept), 2d nmr (gcosy, ghsqc, ghmbc, noesy), and ir spectroscopy. four known cycloartane glycosides, namely, agroastragaloside i (2), agroastragaloside ii (3) ... | 2013 | 23529032 |
| compound astragalus and salvia miltiorrhiza extract suppresses hepatocellular carcinoma progression by inhibiting fibrosis and pai-1 mrna transcription. | astragalus membranaceus and salvia miltiorrhiza have been used for centuries in china to treat liver diseases. previous studies have shown that these herbs and their extracts inhibit the development of liver fibrosis and the proliferation and invasion of human hepatoma hepg2 cells. further study of their pharmacological effects on hepatocellular carcinoma (hcc) is needed. to investigate the effects of compound astragalus and salvia miltiorrhiza extract (case) on diethylinitrosamine (den)-induced ... | 2014 | 24247078 |
| metabolic signatures of kidney yang deficiency syndrome and protective effects of two herbal extracts in rats using gc/tof ms. | kidney yang deficiency syndrome (kds-yang), a typical condition in chinese medicine, shares similar clinical signs of the glucocorticoid withdrawal syndrome. to date, the underlying mechanism of kds-yang has been remained unclear, especially at the metabolic level. in this study, we report a metabolomic profiling study on a classical model of kds-yang in rats induced by hydrocortisone injection to characterize the metabolic transformation using gas chromatography/time-of-flight mass spectrometry ... | 2013 | 24159348 |
| anti-inflammatory and immunoregulatory effects of yupingfeng powder on chronic bronchitis rats. | to investigate the anti-inflammatory and immunoregulatory effects of yupingfeng (, ypf) powder and its components in rats. | 2013 | 23504545 |
| the role of traditional chinese medicines in osteogenesis and angiogenesis. | the article aims to review various traditional chinese medicines (tcms) with both osteogenic and angiogenic effects, alone and in combination, and to consider whether these tcms promote osteogenesis via angiogenesis and vascular endothelial growth factor (vegf). each of the tcms involving in osteogenesis was searched through pubmed and cbmdisc using its latin name and english name, and keywords such as 'osteogenesis', 'bone', 'osteoblast', 'angiogenesis', 'vegf' were used. a total of 241 article ... | 2014 | 23494901 |
| astragalus saponins affect proliferation, invasion and apoptosis of gastric cancer bgc-823 cells. | astragalus memebranaceus is a traditional chinese herbal medicine used in treatment of common cold, diarrhea, fatigue, anorexia and cardiac diseases. recently, there are growing evidences that astragalus extract may be a potential anti-tumorigenic agent. some research showed that the total saponins obtained from astragalus membranaceus possess significant antitumorigenic activity. gastric cancer is one of the most frequent cancers in the world, almost two-thirds of gastric cancer cases and death ... | 2013 | 24152941 |
| microscopic research on a multi-source traditional chinese medicine, astragali radix. | astragali radix is a widely and commonly used chinese herbal medicine, which is derived from roots of astragalus membranaceus var. mongholicus and astragalus membranaceus. to find a quick and reliable method of distinguishing these two species of astragali radix and of determining the age of a sample, microscopic characteristics of the two species were compared using light microscopy. the results showed that the microscopic characteristics, such as number of layers of phellem, continuing lignifi ... | 2014 | 24085529 |
| astragaloside content in the periderm, cortex, and xylem of astragalus membranaceus root. | astragalosides are among the most predominant of the bioactive compounds in the root of astragalus membranaceus and are differentially concentrated depending on the anatomical part of the root in question. the aim of this study was to analyse astragaloside contents in the periderm, cortex, and xylem of a. membranaceus root, and to compare the contents between peeled and unpeeled roots. total astragalosides in the periderm were about 8-fold more concentrated than in the cortex, and 28-fold more c ... | 2013 | 23381847 |
| [separation and purification of total flavonids of astragalus membranaceus with ethanol/phosphate aqueous two-phase system]. | to study separation and purification of flavonids with ethanol/phosphate aqueous two-phase system. | 2012 | 23373209 |
| [effect of astragalus membranaceus var. mongholicus seed extracts on seed germination and seedling growth of different codonopsis pilosula caltiver]. | to reveal the allelopathy effect of astragalus membranaceus var. mongholicus seeds and provide information for the intercrop production. | 2012 | 23373205 |
| pharmacokinetics and hepatic uptake of gliquidone affected by huangqi injection. | the root of astragalus membranaceus also known as huang qi in china is a common traditional chinese herb with extensive pharmacological activities. huangqi injection (hi), a common preparation of huang qi, was wildly co-administered with gliquidone to treat diabetes mellitus and diabetic nephropathy in clinic of china. the aim of the study was to investigate the effect of hi on the pharmacokinetics and hepatic uptake of gliquidone and related mechanism to ensure the safety and efficacy of their ... | 2014 | 24085486 |
| assessment of peeling of astragalus roots using 1h nmr- and uplc-ms-based metabolite profiling. | a metabolomic analysis was performed to examine the postharvest processing of astragalus membranaceus roots with a focus on the peeling procedure using (1)h nmr and uplc-ms analyses. principal component analysis (pca) score plots from the (1)h nmr and uplc-ms data showed clear separation between peeled and unpeeled astragalus roots. peeled roots exhibited significant losses of several primary metabolites, including acetate, alanine, arginine, caprate, fumarate, glutamate, histidine, n-acetylaspa ... | 2013 | 24073592 |
| [optimized treatment program for unstable angina by integrative medicine based on partially observable markov decision process]. | to initially optimize comprehensive treatment program for treating and preventing unstable angina (ua) by integrative medicine (im). | 2013 | 24063205 |
| identification of multiple ingredients for a traditional chinese medicine preparation (bu-yang-huan-wu-tang) by liquid chromatography coupled with tandem mass spectrometry. | bu-yang-huan-wu-tang (byhwt) is a popular traditional chinese medicine formula consisting of seven herbal medicines (astragalus membranaceus, angelica sinensis, paeonia lactiflora, ligusticum chuanxiong, carthamus tinctorius, amygdalus persica and pheretima aspergillum), that has been used in china for centuries to overcome stroke-induced disability. to ensure the consistency of quality, a reliable analytical method is required, therefore, we developed a liquid chromatography with tandem mass sp ... | 2013 | 24036516 |
| extracts from astragalus membranaceus limit myocardial cell death and improve cardiac function in a rat model of myocardial ischemia. | the root of astragalus membranaceus, known as "huang-qi", is one of the most widely used chinese herbal medicines for the prevention and treatment of myocardial ischemic diseases. however, the mechanisms governing its therapeutic effects are largely unknown. | 2013 | 23968862 |
| bibliometric and content analysis of the cochrane complementary medicine field specialized register of controlled trials. | the identification of eligible controlled trials for systematic reviews of complementary and alternative medicine (cam) interventions can be difficult. to increase access to these difficult to locate trials, the cochrane collaboration complementary medicine field (cam field) has established a specialized register of citations of cam controlled trials. the objective of this study is to describe the sources and characteristics of citations included in the cam field specialized register. | 2013 | 23826877 |
| a new herbal formula, ksg-002, suppresses breast cancer growth and metastasis by targeting nf- κ b-dependent tnf α production in macrophages. | tumor-associated macrophages (tams) in tumor microenvironment regulate cancer progression and metastases. in breast cancer, macrophage infiltration is correlated with a poor prognosis. while metastatic breast cancer is poor prognostic with a severe mortality, therapeutic options are still limited. in this study, we demonstrate that ksg-002, a new herbal composition of radices astragalus membranaceus and angelica gigas, suppresses breast cancer via inhibiting tam recruitment. ksg-002, an extract ... | 2013 | 23818931 |
| herbal medicines for viral myocarditis. | herbal medicines are being used as a treatment for viral diseases such as viral myocarditis and numerous clinical trials have been conducted to investigate their efficacy. despite this wealth of evidence, the role of herbal medicines in the treatment of viral myocarditis is yet to be established. this is an update of the review published in 2010. | 2012 | 23152220 |
| astragalus polysaccharide improves muscle atrophy from dexamethasone- and peroxide-induced injury in vitro. | astragalus polysaccharide (aps) is an important bioactive component of astragalus membranaceus bunge (leguminosae) that has been used in traditional chinese medicine for treating muscle wasting, a serious complication with complex mechanism manifested as myofibers atrophy and satellite cells apoptosis. in this study, the anti-atrophy and anti-apoptotic activity of astragalus polysaccharide (aps) was characterized in c2c12 skeletal muscle myotubes and myoblasts. aps inhibited dexamethasone-induce ... | 2013 | 23817095 |