| scedosporium apiospermum infections and the role of combination antifungal therapy and gm-csf: a case report and review of the literature. | scedosporium apiospermum, a ubiquitous environmental mold, is increasingly reported as causing invasive fungal disease in immunocompromised hosts. it poses a therapeutic challenge due to its intrinsic resistance to traditional antifungals and ability to recur despite demonstrating susceptibility. we present an immunocompromised patient with a cutaneous s. apiospermum infection that disseminated despite treatment with voriconazole, the drug of choice. adding echinocandins and gm-csf provided part ... | 2016 | 27182483 |
| scedosporium apiospermum as a rare cause of central skull base osteomyelitis. | we report a case of scedosporium apiospermum mold causing ear infection, central skull base osteomyelitis and finally, occlusion of carotid artery in a 48-year-old diabetic man. the exact diagnosis was established and the severity of the disease understood several months after the onset of symptoms. despite of appropriate antifungal therapy, and repeated surgical and otological procedures, the infection progressed to fatal cerebral infarction. | 2016 | 27134821 |
| histopathological clues in the diagnosis of fungal infection by scedosporium in a case of endophthalmitis starting as conjunctivitis. | cutaneous fungal infections can result in disastrous episodes if improperly diagnosed and treated, especially in immunosuppressed patients. although dermatopathologists are highly familiar with some filamentous fungi - such as aspergillus and zygomycetes - they are not so aware of other less common species. we report a case of ocular infection by scedosporium apiospermum that started as conjunctivitis and resulted in phthisis bulbi and subsequent exeresis of the left eye. we describe some of the ... | 2016 | 26968327 |
| acute scedosporium apiospermum endobronchial infection in cystic fibrosis. | fungi are known pathogens in cystic fibrosis patients. a boy with cystic fibrosis boy presented with acute respiratory distress. bronchoscopy showed airways obstruction by mucus plugs and bronchial casts. scedosporium apiospermum was identified as the only pathogen. bronchoalveolar lavage successfully resolved the acute obstruction. plastic bronchitis is a new clinical picture of acute scedosporium endobronchial colonization in cystic fibrosis patients. | 2016 | 26967814 |
| eyelid mycetoma masquerading as sebaceous carcinoma. | a 56-year-old asian woman presented with an upper eyelid mass. the lesion was exposed after eversion of the eyelid revealing a thickened tarsus with yellowish areas. working diagnosis was sebaceous carcinoma. biopsy was performed. histopathological studies showed a mycotic eumycetoma with splendore-hoeppli phenomena and - microbiologic cultures grew scedosporium apiospermum. the patient was started on voriconazole 200 mg po bid with adequate serum levels. a complete response was observed after 1 ... | 2016 | 26882058 |
| endophthalmitis of probable endogenous origin caused by scedosporium boydii: a case report. | mycotic ocular infections caused by the scedosporium apiospermum species complex are challenging to treat because of the delayed diagnoses and poor responses to antifungal drugs and surgical treatment. | 2016 | 26874584 |
| fungal septal abscess complicating maxillary sinus fungus balls in an immunocompetent host. | fungal infections of the nasal cavity can be destructive entities that are typically seen in immunocompromised hosts. we present a case of a localized fungal abscess of the nasal septum in an immunocompetent host after endoscopic treatment of maxillary sinus fungus balls. | 2015 | 26686210 |
| cutaneous pseudallescheria boydii/scedosporium apiospermum complex (molecular type: scedosporium apiospermum [clade 4]) infection: a case report and literature review of cases from japan. | we report a case of subcutaneous pseudallescheria boydii/scedosporium apiospermum complex infection occurring in a 77-year-old japanese female farmer suffering from interstitial pneumonia. seven months prior to the current presentation, she noticed nodes on her right forearm after pulling up weeds, and the nodes grew larger. two soft dome-shaped, protruded nodes ( 15 mm and 30 mm in size ) had fused together on the extensor surface of the right forearm. yellowish-white, rice-grain-sized pustules ... | 2015 | 26617105 |
| identification of scedosporium boydii catalase a1 gene, a reactive oxygen species detoxification factor highly expressed in response to oxidative stress and phagocytic cells. | scedosporium boydii is an opportunistic filamentous fungus which may be responsible for a large variety of infections in both immunocompetent and immunocompromised individuals. this fungus belongs to the scedosporium apiospermum species complex which usually ranks second among the filamentous fungi colonizing the airways of patients with cystic fibrosis (cf). species of the s. apiospermum complex are able to chronically colonize the cf airways suggesting pathogenic mechanisms allowing persistenc ... | 2015 | 26615753 |
| scedosporium apiospermum causing brain abscess in a renal allograft recipient. | scedosporium apiospermum is the asexual form of a rare fungus pseudallescheria boydii that is usually present in the soil, sewage and dirty water. in immunocompromised patients, it is a rare infection involving multiple organs. we present a case of renal allograft recipient who developed fever two weeks post renal transplant. he was initially found to have dengue fever. after five days, he became drowsy and developed right-sided hemiparesis. magnetic resonance imaging of the brain revealed multi ... | 2015 | 26586067 |
| epidural abscess caused by scedosporium apiospermum in an immunocompetent child. | | 2015 | 26457904 |
| haploidentical hematopoietic cell transplantation with post-transplant cyclophosphamide in a patient with chronic granulomatous disease and active infection: a first report. | we describe haploidentical hematopoietic cell transplantation (hct) with high-dose post-transplant cyclophosphamide (ptcy) in a boy with x-linked chronic granulomatous disease (cgd). | 2015 | 26453586 |
| [pulmonary non invasive infection by scedosporium apiospermum]. | we reported a case of non-invasive pulmonary infection by scedosporium apiospermum in 67 years old female with bronchiectasis and caverns secondary to tuberculosis. diagnosis was made with lung ct and bronchial lavage cultures. the patient was initially treated with itraconazole for six weeks without success and then voriconazole for 16 weeks, with good clinical response. | 2015 | 26436797 |
| pulmonary scedosporiosis mimicking aspergilloma in an immunocompetent host: a case report and review of the literature. | a case of localized lung scedosporiosis is reported here that mimicked aspergilloma in an immunocompetent host. through this case the importance of considering scedosporium spp. in differential diagnosis of locally invasive lung infections and fungal ball is highlighted. as it is difficult to differentiate scedosporium from aspergillus on clinical grounds, microscopy, radiology and histopathology, this case is further emphasizing the significance of the definitive etiological characterization of ... | 2016 | 26353885 |
| scedosporium apiospermum causing otomycosis in an immunocompetent child with tympanostomy tubes: management of this rare entity. | infection following a tympanostomy tube insertion is a common occurrence. scedosporium apiospermum is a filamentous fungus mainly isolated in water and soil. there have been no reported cases of s. apiospermum infection of an immunocompetent individual with a tympanostomy tube in situ. a child was referred with unilateral otorrhoea failing to respond to conventional treatment in the community. s. apiospermum was identified following specialist testing. an extended course of anti-fungal treatment ... | 2015 | 26298623 |
| scedosporium apiosermum infection of the "native" valve: fungal endocarditis in an orthotopic heart transplant recipient. | scedosporium apiospermum is an increasingly appreciated pathogen in immunosuppressed patients. we present a case of s. apiospermum endocarditis in a 70-year-old male who had undergone orthotopic heart transplant. echocardiogram demonstrated a 1.4 cm tricuspid valve vegetation. he underwent valve replacement, complicated by fatal massive post-operative haemorrhage. valve cultures grew s. apiospermum. to our knowledge, our case is the first reported instance of endocarditis caused by s. apiospermu ... | 2015 | 26288748 |
| scedosporium apiospermum infection after near-drowning. | | 2015 | 26228230 |
| paradoxical response preceding control of scedosporium apiospermum mycetoma with posaconazole treatment. | mycetoma is a chronic granulomatous infection that is difficult to treat, notably when due to fungi such as scedosporium apiospermum. recent antifungal agents could be an option, but cases are rarely reported, and none with posaconazole. paradoxical responses, defined as initial clinical worsening despite appropriate treatment, are common in tuberculosis but rare in deep mycoses in non-immunocompromised hosts. hence, paradoxical responses in context other than mycobacterial infection in an immun ... | 2015 | 26114987 |
| scedosporium apiospermum otitis complicated by a temporomandibular arthritis: a case report and mini-review. | scedosporium apiospermum is an ubiquitous fungus responsible for various infections in immunocompromised and immunocompetent patients. ear infections are infrequent. we report an exceptional case of s. apiospermum external otitis complicated by temporomandibular joint arthritis. after 6 months of antibiotherapy, diagnosis was established by mycological analysis of external auditory canal and infratemporal fossae needle sampling. a satisfactory outcome was obtained after 2 months of voriconazole ... | 2015 | 26105580 |
| aortic arch mycotic aneurysm due to scedosporium apiospermum reconstructed with homografts. | a 39-year-old female, active parenteral drug user was diagnosed of spondylodiscitis. a computed tomography (ct) scan showed an extensive aortic arch aneurysm. a positron emission tomography (pet)-ct scan, showing significant aortic wall uptake of the tracer through the whole aortic arch and the d8-d9 intervertebral disc, allowed us to suspect an aortitis despite negative blood cultures. the aneurysm was resected and reconstructed with 2 aortic homografts. cultures of specimens from the aortic wa ... | 2015 | 26046885 |
| keratomycosis caused by graphium eumorphum (graphium state of scedosporium apiospermum). | graphium eumorphum is rarely associated with mycotic keratitis. we report the case of a 30-year-old female presented with complaints of redness and defective vision in the left eye for one month. gram staining and 10% koh wet mount of corneal smears revealed fungal filaments. on potato dextrose agar, fast growing greyish white colonies turning grayish black on maturity was obtained. lactophenol cotton blue (lpcb) staining confirmed the isolate as graphium eumorphum. the infection was resolved wi ... | 2015 | 26023553 |
| concurrent pyoderma gangrenosum and infection with scedosporium apiospermum. | we present a patient with pyoderma gangrenosum (pg) following hip surgery, who developed an exacerbation of her ulceration in conjunction with new areas on her lower limbs. clinically, features of pg and deep fungal infection were apparent. scedosporium apiospermum was isolated from the ulcers. | 2016 | 25920922 |
| disseminated scedosporium apiospermum infection in a near-drowning patient. | | 2016 | 25865289 |
| scedo-select iii: a new semi-selective culture medium for detection of the scedosporium apiospermum species complex. | the scedosporium apiospermum complex is responsible for a large variety of infections in human. members of this complex have become emerging fungal pathogens with an increasing occurrence in patients with underlying conditions such as immunosuppression or cystic fibrosis. a better knowledge of these fungi and of the sources of contamination of the patients is required and more accurate detection methods from the environment are needed. in this context, a highly selective culture medium was devel ... | 2015 | 25841055 |
| interaction between voriconazole and flucloxacillin during treatment of disseminated scedosporium apiospermum infection. | | 2015 | 25777322 |
| a masquerading subcutaneous swelling caused by scedosporium apiospermum: an emerging pathogen. | scedosporiasis is an emerging infection in immunocompromised individuals. we report a case of multiple subcutaneous swellings in a diabetic ketoacidotic patient, which was clinically diagnosed as lipoma. on fine-needle aspiration cytology, pus was aspirated, which showed septate branching hyphal elements. the pus culture on sabouraud's dextrose agar yielded scedosporium apiospermum, which was identified based on its macroscopic and microscopic features. there are very few reports of scedosporias ... | 2015 | 25673611 |
| coccidioidomycosis and other systemic mycoses of marine mammals stranding along the central california, usa coast: 1998-2012. | a wide range of systemic mycoses have been reported from captive and wild marine mammals from north america. examples include regionally endemic pathogens such as coccidioides and blastomyces spp., and novel pathogens like cryptococcus gattii, which appear may have been introduced to north america by humans. stranding and necropsy data were analyzed from three marine mammal stranding and response facilities on the central california coast to assess the prevalence, host demographics, and lesion d ... | 2015 | 25647598 |
| case report of vertebral osteomyelitis and mycotic abdominal aortic aneurysm caused by scedosporium apiospermum in a lung transplant patient with cystic fibrosis. | cystic fibrosis patients are frequently plagued by infections, often with unusual or hardy organisms. their infections are only complicated by transplantation. in this report, we review the case of a young woman who had a double lung transplant secondary to cystic fibrosis who developed a lumbar osteomyelitis/discitis several years after transplantation. after treatment, she went on to develop a mycotic abdominal aortic aneurysm. the patient underwent thoracic and abdominal aortic replacement, a ... | 2015 | 25645805 |
| unusual case of scedosporium apiospermum keratitis following phacoemulsification in a systemically well patient. | we report the case of a 65-year-old immunocompetent woman who developed scedosporium apiospermum keratitis after clear-corneal phacoemulsification. a 3.5 mm by 2.7 mm full-thickness stromal infiltrate, corresponding to the superior 2.75 mm clear-corneal incision, was observed 44 days postoperatively. treatment included preservative-free voriconazole 1.0% hourly, ofloxacin 0.3% 6 times a day, oral voriconazole 200 mg once daily, natamycin 5.0% hourly, dexamethasone 0.1% 4 times a day, and ocular ... | 2015 | 25532648 |
| invasive lung infection by scedosporium apiospermum in an immunocompetent individual. | scedosporium apiospermum previously known as monospermum apiospermum is a ubiquitous fungus found in soil, polluted water and sewage. it causes broad spectrum of diseases, including soft tissue infections, septic arthritis, osteomyelitis, ophthalmic infections, sinusitis, pneumonia, meningitis, brain abscesses, endocarditis and disseminated infection. in recent years, it has been shown to be pathogenic for both immunocompetent and immunosuppressed patients. it is a significant opportunist with v ... | 2016 | 25308027 |
| draft genome sequence of the pathogenic fungus scedosporium apiospermum. | the first genome of one species of the scedosporium apiospermum complex, responsible for localized to severe disseminated infections according to the immune status of the host, will contribute to a better understanding of the pathogenicity of these fungi and also to the discovery of the mechanisms underlying their low susceptibility to current antifungals. | 2014 | 25278533 |
| [deep skin infection with scedosporium apiospermum-infection in a renal transplant patient]. | a 57-year-old immunosuppressed patient presented with multiple erythematous papules and pustules as well as isolated ulcerations on the right lower leg and subcutaneous nodules on the right thigh. the biopsy revealed granulomatous inflammation with numerous fungal hyphae, which were identified as scedosporium apiospermum by pcr. he was treated with voriconazole 2 × 200 mg daily as well assurgical debridement. scedosporium apiospermum is a rare pathogenic agent of deep mold fungus infections. ski ... | 2015 | 25260303 |
| assessing micafungin/triazole combinations for the treatment of invasive scedosporiosis due to scedosporium apiospermum and scedosporium boydii. | scedosporium infections are associated with high therapeutic failure rates. combination therapy may be an alternative approach to improve outcome. the in vitro and in vivo efficacy of micafungin plus posaconazole or plus voriconazole was investigated herein. | 2014 | 24986494 |
| clinical and morphologic findings in disseminated scedosporium apiospermum infections in immunocompromised patients. | scedosporium apiospermum is a ubiquitous, saprophytic, filamentous mold that may cause localized, subcutaneous infections in immunocompetent hosts, but disseminated infection in severely immunocompromised patients. this mold is often highly resistant to multiple commonly used antifungal drugs. even with treatment, there is a high mortality rate. we present two patients with fatal disseminated s. apiospermum infections after bone marrow and lung transplantation. this infection can be rapidly fata ... | 2014 | 24982580 |
| polymicrobial sclerokeratitis caused by scedosporium apiospermum and aspergillus cibarius. | the aim of this study was to report the first case of polymicrobial fungal sclerokeratitis caused by infection with both scedosporium apiospermum and aspergillus cibarius, and notify the medical community of the possibility of infection caused by a. cibarius in humans. | 2014 | 24937168 |
| characterization of scedosporium apiospermum glucosylceramides and their involvement in fungal development and macrophage functions. | scedosporium apiospermum is an emerging fungal pathogen that causes both localized and disseminated infections in immunocompromised patients. glucosylceramides (cmh, glccer) are the main neutral glycosphingolipids expressed in fungal cells. in this study, glucosylceramides (glccer) were extracted and purified in several chromatographic steps. using high-performance thin layer chromatography (hptlc) and electrospray ionization mass spectrometry (esi-ms), n-2'-hydroxyhexadecanoyl-1-β-d-glucopyrano ... | 2014 | 24878570 |
| tumorlike cardiac fungal mycetoma caused by scedosporium apiospermum presenting as symptomatic ventricular tachycardia. | | 2014 | 24821829 |
| [fungal keratitis caused by scedosporium apiospermum: first report from turkey-comment]. | scedosporium apiospermum is a saprophytic fungus which is isolated worldwide in soil, fertilizers, polluted water, rotten vegetables, and other natural environments. it is the cause of mycetoma, a subcutaneous infection, characterized by granule formation. it may also cause severe local or diffuse infections in immunosuppressive patients. s.apiospermum-induced arthritis, endocarditis, keratitis, scleritis, endophthalmitis, meningitis, osteomyelitis, otomycosis, onychomycosis, chronic prostatitis ... | 2014 | 24819276 |
| post-traumatic endophthalmitis secondary to keratomycosis caused by scedosporium apiospermum. | | 2016 | 24724836 |
| atypical fungal vertebral osteomyelitis in a tsunami survivor of the great east japan earthquake. | case report. | 2014 | 24718064 |
| human-impacted areas of france are environmental reservoirs of the pseudallescheria boydii/scedosporium apiospermum species complex. | species of the pseudallescheria boydii/scedosporium apiospermum complex (psc) are emerging fungal pathogens able to chronically colonize the airways of patients with cystic fibrosis (cf). as p. boydii was found more frequently colonizing the lungs of cf patients in france than in other european countries in a previous report, the present study was conducted in order to clarify distribution of psc species in france and to characterize their natural habitat. the highest densities of psc isolates w ... | 2015 | 24684308 |
| [battery of rockets "scedosporium apiospermum" in mycotic keratitis]. | | 2014 | 24576568 |
| successful prevention of scedosporiosis after lung transplantation in a cystic fibrosis patient by combined local and systemic triazole therapy. | a persistent colonization with scedosporium apiospermum (s. apiospermum) often results in disseminated infection with a high mortality rate in immunosuppressed patients. we present the first case of successful prevention of scedosporiosis in an adolescent female cystic fibrosis patient post double lung transplant, with a combination of local and systemic voriconazole therapy and surgical intervention. | 2013 | 24432232 |
| scedosporium apiospermum brain abscesses in an immunocompetent man with silicosis. | we report a case of scedosporium apiosporum brain abscesses in an immunocompetent 69-year-old man with a history of silicosis. delayed diagnosis and institution of antifungal therapy was associated with neurological impairment, with subsequent complications resulting in death, highlighting the need for early diagnostic aspiration of brain abscesses non-responsive to antibiotics. we propose that, in the absence of identifiable immunosuppression, silicosis may have been a contributing factor to th ... | 2013 | 24432222 |
| management of scedosporium apiospermum in a pre- and post-lung transplant patient with cystic fibrosis. | although the predominant type of infection seen in the cystic fibrosis lung remains bacterial, fungal organisms are being isolated more frequently and are associated with a high mortality rate in lung transplant recipients. we present a case of a patient with cf with sputum cultures positive for scedosporium apiospermum prior to a successful lung transplant. she remains without evidence of infection 18 months later following treatment with a combination of triazoles and terbinafine. | 2013 | 24432212 |
| diabetic foot ulcer due to scedosporium apiospermum. | we report a case of diabetic foot ulcer caused by scedosporium apiospermum in a seventy year old male patient with uncontrolled diabetes. scedosporium apiospermum, the asexual phase of pseudallescheria boydii a fungus isolated from a variety of natural substrates throughout the world including soil, polluted water, sewage and manure of poultry and cattle. p.boydii is now recognized as a medically important opportunistic fungus. this case has been reported for its rarity. | 2013 | 24392407 |
| white grain mycetoma caused by scedosporium apiospermum in north india: a case report. | mycetoma is chronic granulomatous infection of skin and subcutaneous tissue caused by both bacteria and fungi. we report a case of mycetoma caused by scedosporium apiospermum in the right foot of a 45-year-old farmer in north india. the patient had a history of trauma in the sole of the right foot followed by discharge of white granules along with proximal progression. scedosporium apiospermum was identified based on colony characteristics and microscopic features on slide culture. mycetoma is a ... | 2013 | 24356247 |
| scedosporium apiospermum: an unreported cause of fungal sporotrichoid-like lymphocutaneous infection in australia and review of the literature. | scedosporium apiospermum is a fungus emerging as a rare but important cause of both localised and disseminated infections in immunocompromised patients. most cutaneous lesions present as mycetoma, however a review of the literature revealed an increasing number of cases worldwide presenting with lymphocutaneous spread resembling sporotrichosis. an 85-year-old man with an extensive medical history including type ii diabetes mellitus and meningioma presented with crusted haemorrhagic areas on the ... | 2015 | 24266687 |
| sporotrichoid eruption in a patient after lung transplantation. scedosporium apiospermum fungal thrombophlebitis and sporotrichoid nodules. | | 2014 | 24258488 |
| [fungal keratitis caused by scedosporium apiospermum: first report from turkey]. | fungal keratitis, an eye infection with poor prognosis, is difficult to treat and can lead to loss of vision. among filamentous fungi scedosporium spp. rarely lead to fungal keratitis. here we present a case of keratitis caused by scedosporium apiospermum. a 61-year-old female patient was admitted to our hospital with the complaints of right eye pain and decreased vision after a foreign body trauma to the right eye. the patient was diagnosed as keratitis by biomicroscopic examination. conjunctiv ... | 2013 | 24237443 |
| skin infection caused by scedosporium apiospermum in immunocompromised patients. report of two cases. | scedosporium apiospermum is a filamentous fungus that can cause cutaneous or extracutaneous disease. a large number of cases have been published over the last decades, mainly in patients immunocompromised as a result of their disease or treatment. these kinds of infections can progress rapidly and become disseminated, leading to very serious or even fatal complications. we report two new cases of skin infection by scedosporium apiospermum from our hospital. | 2013 | 24139365 |
| treatment of a brain abscess caused by scedosporium apiospermum and phaeoacremonium parasiticum in a renal transplant recipient. | cerebral mycosis is a significant cause of morbidity among immunocompromised populations. we present here a case of cerebral infection with scedosporium apiospermum and phaeoacremonium parasiticum in a 49-year-old renal transplant recipient. fourteen years after renal transplantation, the patient presented with invasive pulmonary aspergillosis treated with intravenous liposomal amphotericin b. the patient had clinical and radiographic improvement. however, 6 weeks later, the patient presented wi ... | 2013 | 24050081 |
| an unusual cause of diarrhea in an immunocompromised patient. scedosporium apiospermum colitis and brain abscess. | | 2013 | 23896373 |
| antifungal effects of palmitic acid salt and ultrapure soft water on scedosporium apiospermum. | scedosporium apiospermum sometimes causes serious infectious diseases on the skin of immunodeficient subjects. antifungal effects of fatty acid salts in soap against s. apiospermum were investigated under different water conditions. | 2013 | 23826728 |
| multilocus sequence typing of scedosporium apiospermum and pseudallescheria boydii isolates from cystic fibrosis patients. | scedosporium and pseudallescheria species are the second most common lung-colonising fungi in cystic fibrosis (cf) patients. for epidemiological reasons it is important to trace sources of infection, routes of transmission and to determine whether these fungi are transient or permanent colonisers of the respiratory tract. molecular typing methods like multilocus sequence typing (mlst) help provide this data. | 2013 | 23764085 |
| combination antifungal therapy in the treatment of scedosporium apiospermum central nervous system infections. | treatment of scedosporium apiospermum central nervous system (cns) infection typically consists of an azole in combination with surgical debridement. this approach requires prolonged treatment and carries a high associated mortality. we present two cases of the successful treatment of s. apiospermum cns infections with the combination of voriconazole and terbinafine. | 2013 | 23738164 |
| mycotic keratitis due to scedosporium apiospermum in layer pullets. | investigation of ocular disease in a flock of layer pullets identified corneal infection with scedosporium apiospermum, a fungus of emerging significance in medicine and veterinary medicine. | 2014 | 23710763 |
| [isolation of scedosporium apiospermum (teleomorph: pseudallescheria apiosperma) from an acute myeloid leukemia patient]. | scedosporium apiospermum is an emerging opportunistic pathogen that may lead to life-threatening infections especially in immunosuppressive individuals. in this report, s.apiospermum infection in a 62 year old male patient with acute myeloid leukemia was presented. during remission-induction chemotherapy, piperacillin-tazobactam therapy was started for febrile neutropenia. since fever had continued, treatment was switched to imipenem and also amphotericin b deoxycholate was added to the treatmen ... | 2013 | 23621736 |
| fungal keratitis secondary to scedosporium apiospermum infection and successful treatment with surgical and medical intervention. | to report a rare case of severe fungal keratitis caused by scedosporium apiospermum, which was treated with a penetrating tectonic keratoplasty and aggressive medical treatment. a 62-year-old woman with a history of soil contamination of the right eye while planting vegetables presented with a severe corneal abscess and ocular pain. the patient received medical treatment and underwent tectonic keratoplasty. both corneal scrapings and the corneal button were evaluated microscopically. the samples ... | 2014 | 23612853 |
| scedosporium apiospermum eumycetoma successfully treated with oral voriconazole: report of a case and review of the brazilian reports on scedosporiosis. | we describe a case of white-grain eumycetoma caused by scedosporium apiospermum in an immunocompetent host that was successfully treated with oral voriconazole, and we review the brazilian reports on scedosporiosis. | 2014 | 23563766 |
| unilateral cacosmia: a presentation of maxillary fungal infestation. | we present a case of long-standing unilateral cacosmia in a healthy 67-year-old man due to maxillary fungal infestation. treatment with septoplasty had been attempted 10 years prior but no further investigation or management undertaken and symptoms continued. subsequent mri scan revealed significant opacification of the left maxillary sinus. this was readily amenable to treatment by balloon sinuplasty. this yielded viscous grey mucus which grew scedosporium apiospermum. the case highlights the n ... | 2013 | 23563684 |
| post-tsunami primary scedosporium apiospermum osteomyelitis of the knee in an immunocompetent patient. | scedosporium apiospermum is a filamentous fungus present in soil and polluted waters that may cause infection by direct inoculation. osteomyelitis represents a challenge both for diagnosis and treatment. we report a case of post-tsunami primary s. apiospermum osteomyelitis of the knee in an immunocompetent patient. | 2013 | 23523561 |
| refractory scedosporium apiospermum keratitis successfully treated with combination of amphotericin b and voriconazole. | aim. to report a case of refractory fungal keratitis caused by scedosporium apiospermum. methods. interventional case report. results. a 47-year-old malay housewife presented with left eye cornea ulcer as her first presentation of diabetes mellitus. there was no history of ocular trauma, contact lens used, or cornea foreign body. scedosporium apiospermum was isolated from the cornea scrapping. her cornea ulcer initially responded well to topical amphotericin b within 3 days but subsequently wors ... | 2013 | 23509650 |
| dermatic scedosporium apiospermum infection after autologous bone marrow transplantation. | infection with scedosporium apiospermum (s. apiospermum) is rare, although it is associated with a high fatality rate, especially in immunosuppressed patients. a 23-year-old man with acute myelogenous leukemia (aml) (m2) who was pretreated with chemotherapy for autologous bone marrow transplantation developed a skin ulcer on the left groin. after a culture study demonstrated the presence of s. apiospermum, voriconazole was administered and the lesion rapidly improved. since a diagnosis of s. api ... | 2013 | 23503412 |
| distribution of the different species of the pseudallescheria boydii/scedosporium apiospermum complex in french patients with cystic fibrosis. | as various new sibling species within the pseudallescheria boydii/scedosporium apiospermum complex have been described recently with differences in their susceptibility to antifungals, this study was conducted in order to determine their respective frequency in cystic fibrosis. results indicated that p. boydii largely predominated (62%), followed by s. apiospermum (24%), scedosporium aurantiacum (10%) and pseudallescheria minutispora (4%). scedosporium dehoogii was not recovered in this study. t ... | 2013 | 23461512 |
| cerebral scedosporium apiospermum infection presenting with intestinal manifestations. | we present a case of cerebral scedosporium apiospermum infection presenting with intestinal manifestations in a 64-year-old male patient on immunosuppression for orthotopic liver transplantation. at admission, the patient's chief complaint was chronic watery diarrhea and he was found to have colonic ulcers on endoscopy. his hospital course was complicated by a tonic-clonic seizure caused by a left frontal brain abscess, with the causative agent being identified by culture. he was treated with lo ... | 2013 | 23440749 |
| experimental models of disseminated scedosporiosis with cerebral involvement. | scedosporium apiospermum is a soil fungus which can cause severe and often fatal cerebral infections in both immunocompetent patients in the event of near drowning and immunosuppressed patients such as lung transplant recipients. because of the low susceptibility of this fungus to antifungal drugs, and the low permeability of the blood-brain barrier (bbb), therapeutic drug monitoring is necessary to reach an effective tissue concentration with limited side effects. indeed, diffusion of the drug ... | 2013 | 23426955 |
| scedosporium apiospermum soft tissue infection as the initial presentation of acute myeloid leukemia: a case report. | | 2013 | 23319688 |
| scedosporium apiospermum endophthalmitis: diffusion-weighted imaging in detecting subchoroidal abscess. | to describe the imaging appearance of scedosporium apiospermum (s. apiosermum) endophthalmitis in an immunocompetent female who underwent high resolution magnetic resonance imaging (mri) of the orbits and showed subchoroidal abscess on diffusion-weighted imaging. | 2012 | 23204835 |
| scedosporium apiospermum peritonitis in a patient undergoing peritoneal dialysis. | | 2012 | 22725716 |
| persistent erythematous plaque after minor trauma in an immunocompromised woman. | scedosporium apiospermum is a ubiquitous soil fungus with a worldwide distribution. it can cause a wide range of clinical disease, from cutaneous and subcutaneous infections, to pneumonia, brain abscess, and life threatening systemic illness. the diagnosis of cutaneous disease is with biopsy and culture. we discuss the case of an elderly immunocompromised woman who presented with a persistent erythematous plaque on the elbow after minor trauma. a biopsy revealed scedosporium apiospermum. treatme ... | 2012 | 22559017 |
| scedosporium apiospermum keratomycosis in a dog. | a 6-year-old male castrated norfolk terrier dog was examined following a 21-day history of an increasingly painful eye. examination revealed marked blepharospasm and purulent ocular discharge associated with an ulcerative keratitis. there was panstromal corneal opacity with raised gray to white lesions. corneal cytology demonstrated branching septate fungal hyphae identified by polymerase chain reaction as scedosporium apiospermum. treatment with topical 1% voriconazole solution was successful i ... | 2012 | 22432768 |
| scedosporium apiospermum endopthalmitis treated early with intravitreous voriconazole results in recovery of vision. | the purpose of this study is to report a case of endogenous endopthalmitis caused by scedosporium apiospermum with a favorable outcome and review previously reported cases, their treatment regimens and outcomes. | 2012 | 22370908 |
| [slow onset septic arthritis by scedosporium apiospermum after periarticular infiltration]. | fungal arthritis is usually of haematogenous origin, and mainly affects patients with impaired cellular immunity or users of intravenous drugs. the infection in immunocompetent patients is generally caused by direct inoculation of the microorganism through an invasive device. the experience of azole therapy in these patients is limited. | 2012 | 22366127 |