| excretion, isolation and structure of a new phenolic constituent of female urine. | the regular occurrence of a peak due to an unidentified substance (x) in the gas chromatographic traces obtained from phenolic extracts of urine from human pregnant and non-pregnant females has been reported. the biphasic excretion of x with maxima in the luteal phase of the ovulatory cycle and relatively high levels in the first trimester of pregnancy were noteworthy and suggested that the substance may have a biological significance. close similarities between the excretory pattern, the chemic ... | 1980 | 7432490 |
| monkey responses to three different alarm calls: evidence of predator classification and semantic communication. | vervet monkeys give different alarm calls to different predators. recordings of the alarms played back when predators were absent caused the monkeys to run into trees for leopard alarms, look up for eagle alarms, and look down for snake alarms. adults call primarily to leopards, martial eagles, and pythons, but infants give leopard alarms to various mammals, eagle alarms to many birds, and snake alarms to various snakelike objects. predator classification improves with age and experience. | 1980 | 7433999 |
| meal timing alters circadian rhythm of skin surface temperature in non-human primates. | circadian rhythms of skin surface temperature were demonstrated in a group of african green vervets. alteration of the timing of a single daily meal of fixed caloric content resulted in a shift of the skin surface temperature acrophase in 7 of the 8 series. the timing of the individual temperature acrophases in relation to the light-dark cycle and the extent of acrophase shift in response to alteration of meal timing showed considerable variation between the individual animals studied. | 1980 | 7450921 |
| regulatory genes of simian immunodeficiency viruses from west african green monkeys (cercopithecus aethiops sabaeus). | the high seroprevalence of simian immunodeficiency viruses (sivs) in african green monkeys (agms) without immunological defects in their natural hosts has prompted consideration of siv-infected agms as a model of apathogenic siv infection. study of the molecular mechanisms of sivagm asymptomatic infection could thus provide clues for understanding the pathogenesis of human immunodeficiency viruses. regulatory genes could be candidates for genetic control of sivagm apathogenicity. we have charact ... | 1995 | 7474168 |
| cocaine and cocaethylene: effects on extracellular dopamine in the primate. | cocaine and cocaethylene (a psychoactive metabolite of concurrent cocaine and ethanol consumption) were studied in the anesthetized vervet monkey. the ability of each to elevate extracellular da in the caudate nucleus was assessed using microdialysis probes acutely lowered through chronic guide cannulae. blood samples were also collected to determine plasma levels of the two drugs. doses of 1.5 mumol/kg cocaine (equivalent to 0.5 mg/kg cocaine-hcl) and cocaethylene were administered intravenousl ... | 1995 | 7480546 |
| the presence of alpha-glucosidase, glycerophosphocholine and carnitine in the epididymis and ejaculate of the vervet monkey (cercopithecus aethiops) and the chacma baboon (papio ursinus). | the epididymis is the site of posttesticular sperm maturation in the male genital tract. studies on human epididymides are hampered by the practical inaccessibility of epididymides of healthy men in their reproductive years. the limited use of laboratory animals therefore seems unavoidable. the objective was to establish baseline values of the epididymal markers alpha-glucosidase, glycerophosphocholine (gpc) and carnitine in the lumen of the caput, corpus and cauda epididymidis and in the ejacul ... | 1995 | 7486036 |
| cell-mediated responses of immunized vervet monkeys to defined leishmania t-cell epitopes. | a population of vervet monkeys was immunized with killed parasites and infected with leishmania major promastigotes either by needle or by infected-fly bite. the responses of recovered monkeys to mitogens, killed parasites, and molecularly defined t-cell epitopes were then compared with those of control animals. peripheral blood mononuclear cells (pbmc) from both naive and recovered animals proliferated strongly in response to both b- and t-cell mitogens, although the responses of the recovered ... | 1994 | 7513306 |
| fumonisins: their implications for human and animal health. | fusarium moniliforme is one of the predominant fungi associated with corn intended for human and animal consumption world-wide. fumonisins, food-borne carcinogens that occur naturally in corn, were first isolated and chemically characterized in south africa in 1988. the major metabolite, fumonisin b1 (fb1), was subsequently shown to cause leukoencephalomalacia (lem) in horses, pulmonary edema syndrome (pes) in pigs, and liver cancer in rats. fb1 is also a cancer promoter and initiator in rat liv ... | 1995 | 7582616 |
| pleural mesocestoides and cardiac shock in an obese vervet monkey (cercopithecus aethiops). | only one case of infection by tetrathyridia larvae of the tapeworm genus mesocestoides was detected in 416 necropsies of captive vervet monkeys (cercopithecus aethiops). two hundred nine larvae were distributed between both pleural cavities. mass and size ranges of larvae were determined. a plasma cell reaction indicated a humoral immune response to parasite antigens, which may have contributed to acute, lethal cardiac shock. coagulative myocytolysis was confirmed. the history of this case and a ... | 1995 | 7604505 |
| developmental changes in brain metabolism in sedated rhesus macaques and vervet monkeys revealed by positron emission tomography. | the present positron emission tomography study used 2-deoxy-2[18f]fluoro-d-glucose to examine age-related changes in local cerebral metabolic rates for glucose (lcmrglc) in sedated rhesus macaques and vervet monkeys. nineteen vervet monkeys were scanned in a cross-sectional design, which consisted of three age groups (birth to 59 d, 60-179 d, 180 d to adult) that captured the developmental period of greatest synaptic density within the second group. two rhesus and two vervet monkeys were also ex ... | 1995 | 7613078 |
| fate of a single dose of 14c-labelled fumonisin b1 in vervet monkeys. | the mycotoxin fumonisin b1 (fb1) was dosed as 14c-labelled fb1, to male vervet monkeys (cercopithecus aethiops) both by intravenous (i.v.) injection (2 monkeys, dose 1.72 mg [86 kbq]/kg body weight) and by gavage (2 monkeys, dose 6.42 mg [321 kbq]/kg body weight). excreta were collected over a 24-hr period, whereafter the monkeys were sacrificed and selected organs and contents of the gut collected to determine the distribution of the 14c-label. the bulk of the radioactivity recovered from tissu ... | 1995 | 7648023 |
| evaluation of recombinant gp63, the major leishmania surface glycoprotein, as a diagnostic molecule for leishmaniasis in vervet monkeys. | | 1994 | 7709873 |
| neuronal activity in primate visual cortex assessed by immunostaining for the transcription factor zif268. | it is now well established that environmental signals mediated via neurotransmitters and hormones can induce responses in cells which involve a cascade of receptors, g proteins, and second messengers. these in turn can induce transcription factors which regulate long-term changes in gene expression. it has been proposed that the stimulus-transcription coupling properties of these dna-binding proteins can be exploited to visualize activated neurons by way of immunostaining. we have used standard ... | 1995 | 7718501 |
| neurotoxicity of glucocorticoids in the primate brain. | severe and prolonged physical and psychological stress is known to cause brain damage; long-term torture victims in prison have later developed psychiatric disorders and cerebral cortical atrophy observed in ct scans (jensen, genefke, hyldebrandt, pedersen, petersen, and weile, 1982). in nonhuman primates, we observed degeneration and depletion of the hippocampal neurons in african green monkeys that had been severely abused by cagemates and died with complications of multiple gastric ulcers and ... | 1994 | 7729802 |
| body weights of adult vervet monkeys (cercopithecus aethiops) at four sites in kenya. | | 1994 | 7750866 |
| menstrual cycle and social behavior in vervet monkeys. | we assessed the relationship between social behavior and the menstrual cycle in 11 adult female vervet monkeys (cercopithecus aethiops sabaeus) living in an established, stable social group. the findings indicated that fluctuations in ovarian steroids are accompanied by behavioral changes in vervet monkeys. a significant increase in aggressive action, avoidance of social overtures, and retreats from threat occurred during the late luteal phase. however, the social environment can greatly affect ... | 1995 | 7777657 |
| [post-exposure antirabies vaccination. early serological response to vaccine cultivated on vero cells using a reduced 2-1-1 schedule]. | an abbreviated 2-1-1 schedule for post-exposure rabies vaccination would theoretically lead to more rapid production of specific antibodies than the classical schedule. we measured early serological response to the 2-1-1 schedule. | 1994 | 7831241 |
| visceral leishmaniasis in vervet monkeys: immunological responses during asymptomatic infections. | nine vervet monkeys (cercopithecus aethiops) were infected intradermally with 8 x 10(7) virulent l. donovani promastigotes. four animals developed clinical visceral leishmaniasis and died over a period of 18 months. the remaining five animals have remained asymptomatic for a period of 3 years now. attempts to isolate parasites from spleen and liver through biopsies were fruitless. immunological responses of these subclinically infected animals were examined. enzyme-linked immunosorbent assay (el ... | 1995 | 7863267 |
| oral mucosa of the vervet monkey. | | 1980 | 6160235 |
| assessment of acrosomal integrity of vervet monkey spermatozoa after cryopreservation. | cryopreservation of vervet monkey semen caused a highly significant reduction in the percentage of normal acrosomes and a highly significant increase in the percentage of mildly damaged, severely damaged, and lost acrosomes. this was demonstrated by staining ten post-thaw semen samples, which enabled a visualization of the acrosomal damage. the incidence of post-thaw intact acrosomes in this cryopreservation method was found to be similar to that reported for man and cynomolgus monkey semen. | 1994 | 7869362 |
| trypanosoma brucei rhodesiense: use of an antigen detection enzyme immunoassay for evaluation of response to chemotherapy in infected vervet monkeys (cercopithecus aethiops). | thirty eight trypanosoma brucei rhodesiense-infected vervet monkeys (cercopithecus aethiops) in the late (meningoencephalitic) stage of disease, treated with various trypanocidal drugs, were monitored for a period of more than 600 days to assess the rate of clearance of trypanosome antigens from serum and cerebrospinal fluid (csf). there was a complete but gradual reduction in antigen titres, as assessed by elisa, in animals treated intravenously with melarsoprol, the standard drug for the late ... | 1994 | 7899795 |
| distribution and excretion of a single dose of the mycotoxin fumonisin b1 in a non-human primate. | fumonisin b1 (fb1), a toxic and carcinogenic secondary metabolite of the fungus fusarium moniliforme sheldon, was administered either by i.v. injection or by gavage to vervet monkeys (cercopithecus aethiops). fb1 dosed by i.v. injection to two female vervet monkeys was rapidly eliminated from plasma with a mean half-life during the elimination phase of 40 min. analysis of urine and faeces over a 5 day period after dosing gave an average 47% recovery of the dose as fb1 and its hydrolysed analogue ... | 1994 | 7940579 |
| infection of a yellow baboon with simian immunodeficiency virus from african green monkeys: evidence for cross-species transmission in the wild. | many african primates are known to be naturally infected with simian immunodeficiency viruses (sivs), but only a fraction of these viruses has been molecularly characterized. one primate species for which only serological evidence of siv infection has been reported is the yellow baboon (papio hamadryas cynocephalus). two wild-living baboons with strong sivagm seroreactivity were previously identified in a tanzanian national park where baboons and african green monkeys shared the same habitat (t. ... | 1994 | 7966642 |
| brugia malayi: the diagnostic potential of recombinant excretory/secretory antigens. | the diagnostic potential of recombinant e/s antigens of the lymphatic filaria brugia malayi was investigated by western blot. a cdna expression library was constructed using b. malayi male adult worm mrna, and e/s recombinants were identified with a rabbit antiserum raised against e/s products collected in vitro from b. malayi male and female adult worms. two of these recombinants, bm12 and bm14l, were studied after subcloning the cdna inserts in an escherichia coli plasmid expression and purifi ... | 1994 | 8001660 |
| mosaic genome structure of simian immunodeficiency virus from west african green monkeys. | elucidation of the phylogenetic origins of simian and human immunodeficiency viruses (siv and hiv) is fundamental to the understanding of hiv pathogenesis and the spread of aids worldwide. in this study, we molecularly characterized multiple sivagm isolates from four different african green monkey species (vervet, grivet, sabaeus and tantalus monkeys). phylogenetic analysis of partial (1 kb) env sequences indicated that all sivagm strains cluster together, and that they fall into four distinct s ... | 1994 | 8026477 |
| transplantation tolerance following total lymphoid irradiation in baboon-to-vervet monkey kidney xenotransplantation. | | 1994 | 8029838 |
| delayed-type hypersensitivity responses in vervet monkeys self-cured from experimental cutaneous leishmaniasis. | | 1993 | 8094592 |
| cerebrospinal fluid measurements suggest precursor availability and sex are involved in the control of biogenic amine metabolism in a primate. | biogenic amine precursors and metabolites were measured in cisternal cerebrospinal fluid from 83 female and 55 male vervet monkeys. the results indicate that mean rates of 5-hydroxytryptamine, dopamine, and noradrenaline metabolism in the brain are higher in females than in males. they also suggest that under physiological circumstances tryptophan availability is involved in the control of brain 5-hydroxytryptamine synthesis while tyrosine availability is involved in control of both dopamine and ... | 1984 | 6202838 |
| cryopreservation of vervet monkey semen and recovery of progressively motile spermatozoa. | a method to cryopreserve semen from the vervet monkey (cercopithecus aethiops) has been developed, yielding a mean post thaw recovery of 63.60% of pre-freeze progressive motility. the extender contained a tes-tris buffer, egg yolk, dextrose, streptomycin, penicillin, and glycerol as cryoprotectant. the ph ranged from 7.10-7.18 and the osmolality was 330-345 mosmol/l. | 1993 | 8138985 |
| reserpine as an uncoupler of oxidative phosphorylation and the relevance to its psychoactive properties. | many drugs differing widely in chemical structure uncouple mitochondrial oxidative phosphorylation in vitro. this observation has led to the hypothesis that in vivo uncoupling is the basis of their pharmacological activity. serpasil, a parenteral preparation of reserpine, recently has been shown to uncouple oxidative phosphorylation in vervet monkey kidney mitochondria. although the drug exhibits some properties of a "classical" uncoupler, our studies show that it has a dual effect on energy con ... | 1983 | 6222736 |
| identification of a new subgroup of sivagm in tantalus monkeys. | simian immunodeficiency viruses from african green monkeys (sivagm) can be classified into three subgroups based upon the species from which they were isolated. the most extensively studied subgroup are composed of sivagm isolated from vervet monkeys (cercopithicus pygerythrus). fewer isolates have been characterized from either grivets (cercopithicus aethiops) or green monkeys (cercopithicus sabeus). an additional distinct species of african green monkeys, tantalus monkeys (cercopithicus tantal ... | 1993 | 8212578 |
| a quantitative electron microscope study of desmosomes and hemi-desmosomes in vervet monkey oral mucosa. | | 1983 | 6230431 |
| neutralizing antibodies to simian papovavirus sa12 in old world primates in laboratory colonies: high prevalence in baboons. | sera from 517 laboratory-housed nonhuman primates representing five genera and from 13 laboratory workers were examined for the presence of neutralizing antibodies to sa12 virus. the antibody prevalences were as follows: baboons, 66%; patas and vervet monkeys, 24%; macaques, 8%, and chimpanzees, 2%. the serum of one laboratory worker had antibodies. these results suggest that sa12 virus is a common infection of nonhuman primates in laboratory colonies, especially baboons. | 1980 | 6252324 |
| cone synapses of a flat diffuse cone bipolar cell in the primate retina. | a golgi-stained flat diffuse cone bipolar cell from a vervet monkey's retina (cercopithecus aethiops), contacting six cones, was serially sectioned for electron microscopy (em) to determine the types of synapses it made with the cone pedicles. all the synapses were basal (flat) contacts. their distribution and ultrastructural type were similar at each pedicle. approximately half the synapses were definable as triad-associated and the rest were elsewhere on the cone pedicle base. their ultrastruc ... | 1993 | 8270960 |
| voluntary alcohol consumption in vervet monkeys: individual, sex, and age differences. | the patterns of voluntary alcohol consumption were studied in 35 vervet monkeys (cercopithecus aethiops), classified into four groups. each monkey showed a fairly steady rate during the studied period, resulting in individual differences that became more evident as the treatment evolved. females showed higher alcohol intake frequencies than males. this sexual difference was maintained among adults and juveniles. age differences were also observed: juveniles showed higher frequencies of intake th ... | 1993 | 8309979 |
| lignans in man and in animal species. | in our laboratories, for several years, two phenolic compounds have been detected during gas chromatographic-mass spectrometric analysis of urinary steroid extracts from human and animal species. although features of the mass spectra of their trimethylsilyl (tms) ether derivatives resembled those of oestrogens, they were atypical of steroids. the possibility that they were artefacts of the isolation procedures was discounted after careful studies with blanks, by varying the extraction method and ... | 1980 | 6253812 |
| the potential of vervet monkeys (cercopithecus aethiops) and baboons (papio anubis) as models for the study of the immunology of echinococcus granulosus infections. | nine vervet monkeys and nine baboons were infected with eggs of echinococcus granulosus per os. six of the vervets and one of the baboons possessed hydatid cysts at autopsy, 15-28 months post-infection. the sequential igg response to hydatid fluid and protoscolex antigens showed considerable inter-animal variation. infected vervets and baboons became seropositive after an average of 8 months post-infection. considerable fluctuation in the igg response was observed, particularly to the hydatid fl ... | 1993 | 8341587 |
| protein counterparts of human and simian cytomegaloviruses. | cytomegalovirus (cmv) proteins from isolates of both human (hcmv) and simian (scmv) origin have been compared. three classes were analyzed: the immediate-early (ie) proteins, other infected-cell-specific proteins not present in virus particles, and the proteins that constitute the mature extracellular virion. comparisons were based on one- and two-dimensional (charge-size) separations in denaturing polyacrylamide gels, and on the selectivity of biosynthetic radiolabeling with [32p]orthophosphate ... | 1983 | 6310864 |
| ontogeny of foraging behavior in wild vervet monkeys (cercopithecus aethiops): social interactions and survival. | the ontogeny of feeding behavior was explored by making observations of 32 vervet monkey (cercopithecus aethiops) infants in amboseli national park, kenya. in contrast to adults and juveniles, infants appear to treat all primary food products in their diet as equally valuable. these age-related differences may reflect differences in food preference. to assess social influences, feeding synchrony between mother and infant was explored. from birth to 2 months, infants typically fed asynchronously ... | 1993 | 8375144 |
| genetic variation of the sivagm transmembrane glycoprotein in naturally and experimentally infected primates. | an in-frame stop codon prematurely truncating the transmembrane glycoprotein (tmp) is a common feature of many simian immunodeficiency virus, african green monkey strain (sivagm) molecular clones. the purpose of this study was to investigate the native form of the sivagm tmp in a naturally infected african green monkey (agm) and to study the fate of the stop codon following the passage of sivagm in primates. | 1993 | 8397939 |
| subclinical lumbar polyradiculopathy, polyneuritis and ganglionitis in aged wild and exotic mammalians. | subclinical lumbar polyradiculopathy was present in the intradural dorsal and ventral nerve rootlets of 19 aged individuals of the following wild and exotic mammalian species: woodrat, raccoon, mink, lynx, reindeer, red deer, musk ox, scimitar-horned oryx, arabian oryx, hybrid waterbuck, persian onager, przewalski's wild horse, malayan sun bear, asian elephant, east african river hippopotamus, vervet monkey and rhesus monkey. it was characterized by mild to severe multifocal ballooning of myelin ... | 1993 | 8408784 |
| simian immunodeficiency viruses from central and western africa: evidence for a new species-specific lentivirus in tantalus monkeys. | although up to 50% of african green monkeys (agms) are infected by simian immunodeficiency viruses (siv) in their natural habitat, they remain asymptomatic carriers of these lentiviruses. they provide an attractive model to study not only the origin but also the link among genetic variation, host-virus adaptation, and pathogenicity of primate lentiviruses. sivagm have been isolated from three species of agm: the vervet (cercopithecus pygerythrus), the grivet (cercopithecus aethiops), and the sab ... | 1993 | 8437214 |
| folic acid and vitamin b12 status of vervet monkeys used for nutritional research. | plasma and red blood cell (rbc) folic acid levels, as well as plasma vitamin b12 levels were determined in vervet monkeys (cercopithecus aethiops). all the vervets were apparently healthy and without symptoms or lesions typical of folic acid and/or vitamin b12 deficiencies. competitive protein binding radioassays were used to determine folate and vitamin b12 values in animals fed 4 different diets. the b12 levels for all the groups ranged between 866 and 5867 pg/ml and showed an inverse relation ... | 1993 | 8437437 |
| histological evaluation of quantitative scintigraphy of the salivary glands in a primate model. | to assess the accuracy with which quantitative scintigraphy reflects the true extent of parenchymal losses in diseased salivary glands, the parotid glands of vervet monkeys were unilaterally subjected to experimental injury and studied by scintigraphy and histomorphometry. the glandular 99tcm pertechnetate uptake, relative to a standard dose, was expressed as the ratio of operated to unoperated sides. this was compared with the equivalent ratios of the weights of various salivary component tissu ... | 1984 | 6329975 |
| comparative effects of meal timing on circadian rhythms of plasma insulin and skin surface temperature in non-human primates. | circadian rhythms of plasma immunoreactive insulin and skin surface temperature were demonstrated in a group of african green vervets. alteration in the timing of a single daily meal of fixed calorie content resulted in an acrophase shift of plasma immunoreactive insulin for the group of animals and in an acrophase shift of skin surface temperature in 7 or the 8 animals studied. the acrophase shift of skin surface temperature was considerably less then the shift of acrophase of plasma immunoreac ... | 1983 | 6347560 |
| standardization of radiorenography in dehydrated and rehydrated primates under laboratory conditions. | radiorenography with 99mtc-labelled diethylenetriaminepentacetic acid ( [99mtc]-dtpa) was performed on chacma baboons (papio ursinus) and vervet monkeys (cercopithecus pygerythus) to establish the effects of various states of hydration on the data obtained from the dtpa-renogram. the renogram parameters, which can be related to certain aspects of kidney function, varied significantly with the degree of hydration. it is therefore imperative for clinically directed animal research projects on the ... | 1983 | 6389879 |
| protection against schistosoma mansoni and associated immune responses induced in the vervet monkey cercopithecus aethiops by the irradiated cercaria vaccine. | the efficacy of the radiation-attenuated schistosome vaccine in eliciting protective immunity was investigated in the vervet cercopithecus aethiops. three groups of test animals received one, three, or five exposures to 5,000-9,000 cercariae attenuated with 30 krad of gamma radiation from a 137cs source, while a fourth group served as challenge controls. after a single vaccination, no statistically significant protection was found; after three vaccinations it reached its highest peak (48%) and f ... | 1996 | 8600763 |
| sequence variation and subtyping of human and simian t-cell lymphotropic virus type i strains from south africa. | we report on the subtyping of south african primate t-cell lymphotropic virus type i (ptlv-i) strains by investigating the ltr region using sequence analysis and restriction fragment length polymorphism (rflp) techniques. dna from either uncultured peripheral blood mononuclear cells (pbmcs); cultured pbmc or cell lines of eight human t-cell lymphotropic virus type i (htlv-i); and two simian t-cell lymphotropic virus type i (stlv-i) strains (cercopithecus aethiops pygerythrus) were amplified by p ... | 1996 | 8673535 |
| vasoactive intestinal polypeptide (vip) as a putative neurotransmitter in penile erection. | the localization of vasoactive intestinal polypeptide (vip) in the male genitourinary tract was investigated in the rabbit and man by means of radioimmunoassay and immunohistochemistry. in addition, the in vitro effect of vip upon penile smooth muscle from man, the vervet monkey, and the rabbit was investigated. significant concentrations of vip immunoreactivity were found in the human penis and all the organs of the rabbit genital tract apart from the testis. vip immunoreactive nerve fibres wer ... | 1983 | 6410140 |
| a mobile cage facilitates periodic social contact and exercise for singly caged adult vervet monkeys. | a mobile exercise cage that expands the quantity and improves the quality of the space available to singly caged adult vervet monkey males is described. it was easily fitted into an existing caging system and the addition of a resident consort female made it possible for the males to mate and have regular social contact. | 1996 | 8740955 |
| vaccination of vervet monkeys against cutaneous leishmaniosis using recombinant leishmania 'major surface glycoprotein' (gp63). | vervet monkeys (cercopithicus aethiops) were shown to give a positive delayed-type hypersensitivity (dth) reaction to gp63, a major surface glycoprotein of leishmania parasites, and also produce antibodies to the molecule following a triple vaccination with a total dose of 150 micrograms of recombinant gp63 mixed with bacille calmette guerin (bcg). however, peripheral blood leucocytes (pbl) from these animals neither proliferated nor produced any interferon-gamma (ifn-gamma) following in vitro s ... | 1995 | 8747903 |
| disruption of sphingolipid metabolism in non-human primates consuming diets of fumonisin-containing fusarium moniliforme culture material. | the fumonisin mycotoxins are produced by fusarium moniliforme sheldon, a contaminant of corn worldwide. the two most abundant analogues (fumonisins b1 and b2) are known to be potent inhibitors of sphingosine n-acyltransferase (ceramide synthase) and hence to disrupt de novo sphingolipid biosynthesis. the sphingoid bases, sphingosine and sphinganine (and hence their ratio), were measured at varying intervals over a period of 60 weeks in the serum of non-human primates (vervet monkeys; cercopithec ... | 1996 | 8783447 |
| cryopreservation of mature teeth before replantation in monkeys (i). effect of different cryoprotective agents and freezing devices. | cryopreservation is clinically relevant in storage of teeth for transplantation or replantation. the effect of cryopreservation was studied by histometric analysis of 60 teeth replanted in 10 green vervet monkeys. the following cryopreserving agents were examined: 5% and 10% dimethylsulfoxide (dmso) and 10% glycerol. furthermore, 2 types of freezing method were compared: automatic biological freezing (cryoson) and a simplified freezing device of sperling. cryopreserved teeth were stored for 1 we ... | 1983 | 6425233 |
| pulpal response to a bis-acryl-plastic (protemp) temporary crown and bridge material. | the pulpal response to protemp (espe gmbh) was compared to zinc oxide-eugenol, super syntrex (de trey) and protemp plus zinc oxide-eugenol liner in 144 vervet monkey (cercopithecus pygerythus) incisor teeth, according to ada specification no. 41. cellular displacement into dentinal tubules, superficial and deep inflammation were present only in the 3-day specimens in all materials. mean scores for the test material were lower than both negative and positive controls. in the 30-day specimens the ... | 1984 | 6440957 |
| growth and morphological characteristics of vervet monkey bone marrow-derived adherent cells. | monkey bone marrow-derived adherent cells were maintained in culture for six months. phase contrast and scanning electron microscopy showed two cell shapes: fusiform and polygonal. no difference was observed in the cyto-chemical staining of the two shapes. both stained positively for alpha-napthyl acetate esterase, acid phosphatase, collagens i and iii, and lipids and negatively for peroxidase and factor viii antigen. a small proportion (1.5%) were alkaline phosphatase-positive. an average of 14 ... | 1984 | 6491392 |
| fiber architecture of the extensors of the hindlimb in semiterrestrial and arboreal guenons. | fiber architecture of the extensor musculature of the knee and ankle is examined in two african gueon species--the semiterrestrial cercopithecus aethiops, and the arboreal c. ascanius. using histologic and microscopic techniques to measure lengths of sarcomeres, the original lengths of muscle fasciculi and angles of pinnation in quadriceps femoris and triceps surae are reconstructed from direct measurements on cadavers. calculations of reduced physiological cross-sectional area, mass/predicted e ... | 1996 | 8850183 |
| lysosomal acid deoxyribonuclease from vervet monkey livers--i. purification and physico-chemical characterization. | acid dnase from monkey liver lysosomes was purified to homogeneity by salt extraction of lysosomal membranes at ph 3.8; (nh4)2so4 fractionation; low salt precipitation; sp-c50 and g-150 sephadex chromatography; and polyacrylamide gel electrophoresis. the ph for optimum activity was dual in character with a labile optimum at ph 3.8 and a less active but stable one at ph 4.2. the estimated molecular weight was 40k and the pi was 4.4. inorganic ions such as ca2+, mg2+, mn2+ and so2-4 were more than ... | 1984 | 6530007 |
| trypanosoma brucei rhodesiense infection in vervet monkeys. ii. provocation of the encephalitic late phase by treatment of infected monkeys. | four out of 8 monkeys infected with trypanosoma rhodesiense and treated with trypanocidal drugs at various intervals after infection (days 55-58, days 62-65, day 68) developed encephalitis. in 2 of these animals, killed 2 weeks after treatment, the encephalitis presenting was incipient; the other 2 monkeys died as a result of severe encephalitis a little more than 2 and 3 months after treatment, respectively. at the time of treatment, the animals revealed a parasitization of the csf, but there w ... | 1982 | 7164167 |
| neuronal synchronization of tonically active neurons in the striatum of normal and parkinsonian primates. | 1. previous studies indicate that tonically active neurons (tans) are the cholinergic interneurons of the striatum and predict that their activity is synchronized. to test whether tans do fire synchronously, and whether dopamine depletion affects their synchronization, we recorded the simultaneous activity of several tans in the putamens of two vervet monkeys before and after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) treatment. 2. cross-correlation analysis revealed that most pairs of ... | 1996 | 8890317 |
| changes in wga-lectin binding sites on sperm during epididymal transit in the chacma baboon (papio ursinus) and the vervet monkey (cercopithecus aethiops). | epididymal maturation of sperm entails molecular changes to the sperm plasma membrane. these changes are reflected by changes in lectin binding. the wheat germ agglutinin (wga) lectin was used, since it binds to acetylglucosamine and sialic acid, which are involved in sperm function. the objective was to study changes in wga-lectin binding during epididymal passage and in the ejaculate of the chacma baboon and vervet monkey. the intensity and location of lectin binding on sperm from the ejaculat ... | 1996 | 8907669 |
| serum aminopeptidases in pregnant vervet monkeys (cercopithecus aethiops). | two distinctive aminopeptidase isozymes have been identified in the serum of the vervet monkey. the l-methionine-sensitive cytosol aminopeptidase (ap; e.c. 3.4.11.1) is present in all samples, while the cystyl aminopeptidase (cap; e.c. 3.4.11.3) isozyme, which is resistant to inhibition by 0.1 m l-methionine, is found only in the serum of pregnant females. the pregnancy-specific cap isozyme appears in the serum between the fifth and the eleventh weeks of a nearly 22-week pregnancy. the overall a ... | 1982 | 7181846 |
| occurrence and frequency of transmission of naturally occurring simian retroviral infections (siv, stlv, and srv) at the cirmf primate center, gabon. | among the primates held at the cirmf primate center, gabon, no serological sign of siv infection could be demonstrated in 68 cynomolgus monkeys, 60 chimpanzees, nine gorillas, and 12 sun-tailed monkeys, while seven of 102 mandrills and six of 24 vervets were infected with siv. six mandrills, seven vervets and ten cynomolgus monkeys exhibited a full htlv type 1 western blot profile. the sera of two gorillas and one chimpanzee presented with a positive but not typical htlv western blot profile. th ... | 1996 | 9029395 |
| heterologous protection by leishmania donovani for leishmania major infections in the vervet monkey model of the disease. | the study was aimed at analyzing immunological cross-reactivity between leishmania major and leishmania donovani and possible cross-protection between the two parasite species in the vervet monkey model of the disease. nine vervet monkeys (cercopithecus aethiops) from the institute animal colony were sued in the study. five of the animals had been previously infected with l. donovani but had remained asymptomatic while the other four animals were naive and comprised the control group. immunologi ... | 1997 | 9030661 |
| distribution of endocrine cells displaying immunoreactivity for one or more peptides in the pancreas of the adult vervet monkey (cercopithecus aethiops). | our previous studies on the chacma baboon revealed that the most striking difference between islets of the ventral and dorsal regions of the pancreas was their content of a and pancreatic polypeptide (pp) cells with a cells predominating in the tail and pp cells in the uncinate and head. cells displaying dual immunoreactivity for both glucagon and pp were also observed. the objective of this study was to establish baseline parameters of the adult vervet monkey (cercopithecus aethiops) pancreas s ... | 1997 | 9066918 |
| blood protein variation in a population of ethiopian vervet monkeys (cercopithecus aethiops aethiops). | seven small groups of vervet monkeys (cercopithecus aethiops aethiops), totaling 124 individuals, from awash national park, ethiopia, were trapped and blood samples were obtained. twenty-three loci were examined by starch gel electrophoresis and four loci, tf, e, ada, and pmg2 were found to be polymorphic. the average heterozygosity (h) of the population was calculated to be 5.6%. no significant deviations from hardy-weinberg equilibrium proportions occurred and a chi-square test for group homog ... | 1981 | 7258346 |
| a full-length and replication-competent proviral clone of sivagm from tantalus monkeys. | african green monkeys (agm) are classified into four distinct species (commonly termed vervet, grivet, sabaeus, and tantalus monkeys), all of which are known to be infected with simian immunodeficiency virus (sivagm) in the wild. sequence analysis of partial gag and env regions has indicated that each of the four species harbors a phylogenetically distinct sivagm subtype. this species-specific diversity suggests that african green monkeys have been infected with sivagm for an extended period of ... | 1997 | 9123848 |
| pharmacokinetics of melarsoprol in uninfected vervet monkeys. | the level of the trypanocidal drug melarsoprol was determined in serum and cerebrospinal fluid (csf) of six healthy vervet monkeys after intravenous application of the drug following a standard treatment schedule and a recently suggested alternative protocol. the maximum serum levels measured were about 3 micrograms/ml. a three-compartment model was used to analyze the serum data. the mean residence time calculated for melarsoprol in serum was 18 h, the volume of distribution was 3.6 l/kg and th ... | 1994 | 7863853 |
| growth, development, and sexual dimorphism in vervet monkeys (cercopithecus aethiops) at four sites in kenya. | body weight and ten body segment measurements were collected from 367 wild-trapped vervet monkeys (cercopithecus aethiops) in central and southern kenya. the animals represent between 70 and 95% of the animals in each of 30 troops at four geographical locations separated by 80 to 380 km. the capture sites differed in altitude, mean annual rainfall and temperature. two questions are addressed: (1) what are the differences in male and female growth patterns, and (2) what is the relationship betwee ... | 1997 | 9185950 |
| determination of the mycotoxin fumonisin b1 and identification of its partially hydrolysed metabolites in the faeces of non-human primates. | a method has been developed for the determination of fumonisin b1 (fb1) in the faeces of non-human primates (vervet monkeys). the animals were dosed with 14c-labelled fb1, and the radioactive compounds in faeces were recovered by repeated extractions with 0.1 m ethylenediaminetetraacetic acid. the extracts were cleaned-up on a reversed-phase (c18) solid-phase extraction cartridge, and fb1 was determined by o-phthaldialdehyde derivatization and reversed-phase hplc. the analytical method for the d ... | 1994 | 8132161 |
| experimental schistosoma mansoni infection in vervet monkeys (cercopithecus aethiops) in kenya: i. susceptibility to a primary infection. | groups of five 3-kg kenyan monkeys, cercopithecus aethiops, were exposed individually to 150,600 or 1500 schistosoma mansoni cercariae per monkey. three monkeys died soon after the infections became patent and the survivors were autopsied 4 months after exposure. mortality and most haematological, parasitological and pathological sequelae of infection were dose-related, but not the white cell response or changes in the levels of serum proteins or fibrinogen. no gross liver fibrosis was seen. com ... | 1984 | 6747261 |
| enduring cognitive deficits and cortical dopamine dysfunction in monkeys after long-term administration of phencyclidine. | the effects of the psychotomimetic drug phencyclidine on the neurochemistry and function of the prefrontal cortex in vervet monkeys were investigated. monkeys treated with phencyclidine twice a day for 14 days displayed performance deficits on a task that was sensitive to prefrontal cortex function; the deficits were ameliorated by the atypical antipsychotic drug clozapine. repeated exposure to phencyclidine caused a reduction in both basal and evoked dopamine utilization in the dorsolateral pre ... | 1997 | 9252326 |
| receptor imaging with atrial natriuretic peptide. part 1: high specific activity iodine-123-atrial natriuretic peptide. | atrial natriuretic peptide (anp) was labeled in high specific activity using 123i (p,2n). the biodistribution of 123i-anp was studied in green vervet monkeys by gamma scintigraphy and in rats by dissection and gamma counting. iodine-125-anp was also studied in monkeys by in vitro autoradiography. | 1994 | 8151387 |
| severe long-term 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in the vervet monkey (cercopithecus aethiops sabaeus). | the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) produces parkinsonian neurochemical and functional deficits in human and non-human primates. the utility of mptp-induced parkinsonism in monkeys as an animal model of parkinson's disease would be greater if it produced a persistent and stable behavioural syndrome so that the effects of novel therapeutic treatments can be accurately assessed. further, the claim that many species including primates spontaneously recover from mptp i ... | 1997 | 9316026 |
| parathyroid hormone, ionised calcium, and potentially interacting variables in plasma of an old world primate. | bone turnover and calcium homeostasis in man can only be modelled validly in old world nonhuman primates. in order to interpret the models it is necessary to establish endocrine and biochemical parameters of bone mineral metabolism. this report is probably the first description of acute phase parathyroid responses to manipulations of blood ionised calcium, and of reference values for potentially interacting variables, in vervet monkeys. plasma parathyroid hormone concentrations were measured in ... | 1993 | 8230175 |
| recent developments in alcoholism:genetic transmission. | this chapter is an overview of developments in the study of genetic factors in vulnerability in alcoholism. the focus is on recent developments, including heritability studies in twins and transmission studies in families, both of which have continued to reveal evidence for a substantial role for genetic factors but also for etiologic complexity and variation in vulnerability across generations and across cultures. studies are discussed which utilized psychophysiological and neurochemical marker ... | 1993 | 8234925 |
| serotonergic and catecholaminergic influence on thyroid function in the vervet monkey. | vervet monkeys were pharmacologically treated acutely and with repeated dose loading to alter serotonergic systems to assess the role of serotonin in the regulation of the hypothalamus-pituitary-thyroid axis. acute l-tryptophan administration failed to alter basal levels of thyroid hormones but did decrease the trh-induced tsh response. repeated dose loading of tryptophan or 5-hydroxytryptophan increased blood serotonin and plasma t3 and decreased plasma tsh. the tryptophan hydroxylase inhibitor ... | 1980 | 6780370 |
| further analysis of ricin's pyrogenic effect. | ricin (ric) the toxic protein of castor oil seeds (ricinus communis, euphorbiaceae;) given intraperitoneally in sublethal doses causes fever in a dose-dependent manner in the following mammals: rabbit, cat, guinea pig, rat and vervet monkey. this hitherto unknown property of ricin calls attention to its use as a pyrogen-substance in the pharmacological screening of new antipyretic drugs. | 1993 | 8312713 |
| relation between phylogeny of african green monkey cd4 genes and their respective simian immunodeficiency virus genes. | an apparent species-specific relatedness of sivagm suggests a coevolution with their natural hosts. however, the exact species or subspecies classification of african green monkeys, agm, is uncertain because current classification schemes rely on phenotype markers, while more definitive genetic data are lacking. in this study, the cd4 protein involved in tissue type recognition was genetically cloned and sequenced from pbmc rna from all agm species, including barbados green monkeys (bgm). phylog ... | 1997 | 9379478 |
| the presence of cryptosporidium oocysts in stools of clinically diarrhoeic and normal nonhuman primates in kenya. | a total of 114 nonhuman primates comprising 51 vervet monkeys (cercopithecus aethiops) and 63 olive baboons (papio anubis) were examined for cryptosporidium oocysts using the modified kinyoun's acid-fast staining technique. about 51.7% (59/114) of all the specimens examined, representing 78.4% (40/51) of the vervet monkeys and 30.1% (19/63) of the olive baboons were positive. bright red, refractile cryptosporidium oocysts were observed in the stained faecal smears against a blue background. up t ... | 1997 | 9404840 |
| periodontal healing after replantation and autotransplantation of incisors in monkeys. | the effect of injury to the cemental or alveolar part of the periodontal ligament upon periodontal healing after replantation and autotransplantation of teeth was studied in green vervet monkeys. sixty-six maxillary central incisors were replanted or autotransplanted after extra-alveolar periods of 18 min. saline storage or 120 min. dry storage. the animals were sacrificed after 8 weeks and the teeth examined histometrically. identical healing was found in the following experimental groups: repl ... | 1981 | 6792095 |
| effects of large neutral amino acid concentrations on 6-[f-18]fluoro-l-dopa kinetics. | 6-[f-18]fluoro-l-3,4-dihydroxyphenylalanine (fdopa) has been used to measure the central dopaminergic function in many species, including humans and monkeys. for transport across the blood brain barrier (bbb), fdopa competes with plasma large neutral amino acids (lnaa). in this article we evaluate the effects of normal physiological lnaa concentration variation on bbb transport (k1) and the fdopa uptake measurement, ki. we also investigate a method for reducing the dependency of fdopa quantitati ... | 1998 | 9428304 |
| atherosclerosis: aortic lipid changes induced by diets suggest diffuse disease with focal severity in primates that model human atheromas. | atherosclerosis in vervet or african green monkeys (cercopithecus aethiops) models the morphology and cytology of the disease of humans, and it is well established that the rate of atherogenesis in vervets is influenced by diet. aortic intimal concentrations of lipids and phospholipids known to be major components of atheromas were determined in female vervets fed for 4 years on either an atherogenic (ad) or a prudent western diet (pd). lipid concentrations detectable microscopically as choleste ... | 1998 | 9437677 |
| the effect of diet on the vervet monkey endocrine pancreas. | vervet monkeys (cercopithecus aethiops) used for pancreatic endocrine cell distribution studies were found to have been maintained on different diets. although the effect of dietary changes on the exocrine pancreas has been described in several animals, little, apart from the effect of malnutrition, has been reported for the endocrine pancreas. reported here are pancreatic endocrine cell distributions in monkeys on a standard diet (n = 3) compared with monkeys on an atherogenic diet (n = 3). qua ... | 1997 | 9438224 |
| complex evolutionary history of primate lentiviral vpr genes. | vpx and vpr are homologous proteins encoded by the human and simian immunodeficiency viruses. vpr is encoded by each of the five primate lentiviral groups, whereas vpx is restricted to members of the hiv-2 group. a recent report has proposed that the vpx gene was probably acquired from an ancestral member of the sivagm group by nonhomologous recombination. here, we suggest that this transfer event was more likely to have occurred via homologous recombination within the 3' region of another gene, ... | 1998 | 9454696 |
| induction of cell proliferation and differentiation in the pancreas of the adult vervet monkey (cercopithecus aethiops): preliminary results. | cellophane wrapping of the adult syrian golden hamster pancreas has been found to result in ductular cell proliferation leading to islet regeneration. injection of cytosol from a cellophane-wrapped pancreas into normal or diabetic hamsters evoked a similar response. in view of the therapeutic potential of the active substance in this cytosol, it was decided to investigate whether a similar response could be achieved in a primate. in normal adult vervet monkey (cercopithecus aethiops) pancreas, p ... | 1998 | 9510134 |
| locomotor activity differences between sympatric patas monkeys (erythrocebus patas) and vervet monkeys (cercopithecus aethiops): implications for the evolution of long hindlimb length in homo. | homo erectus is notable for its taller stature and longer lower limbs relative to earlier hominids, but the selective pressures favoring such long limbs are unclear. among anthropoid primates, patas monkeys (erythrocebus patas) and extant hominids share several extreme characteristics involved with foraging and movement, including the relatively longest lower limb proportions, longest daily travel distances and largest home ranges for their body or group size, occupancy of some of the driest hab ... | 1998 | 9511914 |
| evaluation of the monoamine uptake site ligand [123i]methyl 3 beta-(4-iodophenyl)-tropane-2 beta-carboxylate ([123i]beta-cit) in non-human primates: pharmacokinetics, biodistribution and spect brain imaging coregistered with mri. | the in vivo properties of a new radioiodinated probe of the dopamine and serotonin transporter, [123i]methyl 3 beta-(4-iodophenyl)tropane-2 beta-carboxylate ([123i]beta-cit) were evaluated in baboons and vervet monkeys. the labeled product was prepared in 65.2 +/- 2.8% yield (mean +/- sem; n = 18) by reaction of the tributylstannyl precursor with [123i]nai in the presence of peracetic acid followed by high pressure liquid chromatography (hplc) purification to give a product with radiochemical pu ... | 1993 | 8358345 |
| epithelial alpha-naphthyl acetate esterases in the green vervet monkey gingiva before and after periodontal surgery and during tooth eruption. | to provide enzymatic information on de novo formed junctional (je) and sulcular epithelium (se), we performed periodontal surgery on 24 teeth. ten to 14 days postoperatively, all experimental and 16 control teeth were extracted with adjacent buccal gingiva. in addition, specimens from unerupted and partly erupted teeth containing enamel epithelium (ee) were examined. fixed cryostat sections were cut in series, stained with he, or incubated with and without substrate for demonstration of alpha-na ... | 1993 | 8456257 |
| effect of cutting speeds and a cavity liner on the pulpal response to nobetec. | the investigation was undertaken to determine the response to nobetec, a modified zinc oxide-eugenol cement, widely used as a negative control material in pulpal studies, under conditions of high- and low-speed cavity preparation, with and without a cavity liner dycal. the pulpal responses were evaluated at intervals of 2 days, 2 weeks and 8 weeks in the permanent maxillary and mandibular incisors in 26 vervet monkeys using labial class v cavities prepared in 208 teeth. nobetec was found to be m ... | 1981 | 6792335 |
| hemagglutination properties and nucleotide sequence analysis of the fiber gene of adenovirus genome types 11p and 11a. | the fiber has been suggested to serve as the ligand between the adenovirus capsid and the host cell receptor. the two genome types, ad11p and ad11a, of adenovirus serotype 11 display different tropisms. the fiber amino acid sequences of the two genome types have been deduced from the 975 nucleotides that encoded a fiber polypeptide of 35,500 da. the fiber consists of a tail, a shaft, and a knob region. the amino acids 44 to 140 form a typical shaft domain of six 15-residue repetitive motifs. ten ... | 1993 | 8503168 |
| upregulation of striatal d2 receptors in the mptp-treated vervet monkey is reversed by grafts of fetal ventral mesencephalon: an autoradiographic study. | although neural transplantation holds promise as a treatment for parkinson's disease, parkinsonian primates have generally exhibited inconsistent and incomplete recovery of motor functions following intrastriatal grafting of fetal ventral mesencephalon. one possible contributing factor to this variable response is lack of appropriate integration of donor neurons with host striatal circuitry with the result that there is insufficient dopamine release and postsynaptic dopamine receptor activation. ... | 1998 | 9622593 |
| simian immunodeficiency viruses (sivs) from eastern and southern africa: detection of a sivagm variant from a chacma baboon. | simian immunodeficiency viruses (sivs) have been shown to infect many old world african primate species. thus far, no work has been published on southern african primates. in this study we investigated the genetic diversity between siv strains from kenyan and south african vervets (cercopithecus aethiops pygerythrus). we amplified and sequenced a 1113 bp region of the env gene. phylogenetic analysis of these sequences showed that all strains clustered with members of the vervet subgroup of sivag ... | 1998 | 9680146 |
| evaluation of different types of autotransplanted connective tissues as potential periodontal ligament substitutes. an experimental replantation study in monkeys. | the purpose of the present study was to investigate connective tissue autotransplants as potential periodontal ligament substitutes. green vervet monkeys (cercopithecus aethiops) were used. maxillary permanent central incisors were extracted, root filled extraorally and the periodontal ligament removed from the root surface and the socket wall. two circular cavities were prepared mesially and distally on the root surface. different types of connective tissue autotransplants were then placed in t ... | 1981 | 6797974 |
| serotypic characterization of outer capsid spike protein vp4 of vervet monkey rotavirus sa11 strain. | the vervet monkey rotavirus sa11, a prototype strain of group a rotaviruses, has been shown to possess vp7 serotype 3 specificity but its neutralization specificity with regard to the other outer capsid protein vp4 has not been elucidated. we thus determined its vp4 specificity by two-way cross-neutralization with guinea pig antiserum prepared with a single gene substitution reassortant that had only the vp4-encoding gene from the simian rotavirus sa11 strain and remaining ten genes from human r ... | 1998 | 9687880 |
| trypanosoma brucei rhodesiense infection in vervet monkeys. i. parasitologic, hematologic, immunologic and histologic results. | twenty vervet monkeys infected with t. rhodesiense (eatro 1989) developed chronic disease with an average duration of 65 days (variation 35-107 days). with respect to the course of the disease, and to the hematologic, immunologic and histological findings, the disease faithfully mirrored human t. rhodesiense infection. in all animals, parasitization of the csf occurred only a few weeks after infection, and was accompanied by an increase in the cell count and the appearance of igm in the csf. the ... | 1982 | 7164166 |
| pulp reactions to restoration of experimentally induced crown fractures. | reattachment of the avulsed enamel-dentine coronal fragment to the remaining tooth structure has become an accepted clinical alternative to a resin composite build-up for the restoration of crown fractured teeth. since little knowledge exists as to the pulpal response to this procedure, this study was designed to observe the condition of the pulp following experimentally induced crown fracture and restoration in monkeys. | 1998 | 9699430 |
| altered dopamine transporter densities in alcohol-preferring vervet monkeys. | altered dopamine (da) transporter densities have been implicated in mechanisms of vulnerability and relapse in human alcoholics. the regional distribution and density of the da transporter was studied in alcohol-preferring vervet monkeys to investigate baseline status and regulation of the da transporter at different stages of chronic alcohol drinking. combined ligand binding and in vitro autoradiography of the cocaine congener [125i]rti-55 (beta-cit) demonstrated a significant increase in da tr ... | 1996 | 8730805 |
| the non-human primate endocrine pancreas: development, regeneration potential and metaplasia. | an investigation into the development of the vervet monkey endocrine pancreas revealed a sequence of occurrence of pancreatic peptides that differed from previous reports in mice, dog and human with pp and somatostatin occurring before glucagon and insulin. all four pancreatic peptides were identified, immunohistochemically, in only one of the pancreatic primordial buds, before fusion of the two buds to form the pancreas. this questions the hypothesis that the heterogeneous endocrine cell distri ... | 1996 | 8935153 |
| ethological and 6-[18f]fluoro-l-dopa-pet profiles of long-term vulnerability to chronic amphetamine. | a chronic 10-day amphetamine (amp) protocol was used to induce significant long-term decrements of the striatal [18f]fluoro-l-dopa influx rate constant (fdopa ki) in the vervet monkey. longitudinal fdopa-positron emission tomography (pet) assessment in amp-treated subjects subsequently revealed a gradual recovery of striatal dopamine function: fdopa ki values were decreased by approximately 70% at 1 month, approximately 45% at 6 months, approximately 20% at 12 months and were similar to pre-amp ... | 1997 | 9079790 |
| nitric oxide production in vervet monkeys (cercopithecus aethiops) infected with trypanosoma brucei. | a retrospective study of nitrate concentration in serum and cerebrospinal fluid (csf) from vervet monkeys (cercopithecus aethiops) infected with trypanosoma brucei was undertaken. serum nitrate was significantly elevated in parasitaemic animals. csf nitrate detection correlated with the presence of parasites in the cns. the results provide evidence for the production of nitric oxide (no) in response to infection in a primate model of human african trypanosomiasis and provide the basis for the us ... | 1998 | 9767605 |