| interaction of alpha adrenergic blockade and co2 effects on the regulation of tissue o2 levels in brain. | | 1977 | 23096 |
| the action of hypercapnia during hypoxia on pulmonary vessels. | two opposing actions of co2 on pulmonary vessels, vasoconstriction and vasodilatation, were studied in dogs, cats, ferrets and rats using isolated lungs or a lobe of lung in vivo. both preparations were perfused at a constant flow rate so that changes in inflow pressure at constant outflow pressure represented changes in vascular resistance. lungs were ventilated with 5-15 percent co2 during hypoxic vasoconstriction in order to permit demonstration of dilatation and because the two stimuli frequ ... | 1977 | 23189 |
| dystonia musculorum deformans--a status report. | | 1976 | 23190 |
| inhibition of somato-sympathetic reflex via peripheral presynaptic alha-adrenoceptors. | in cats anaesthetized with chloralose--urethane (70/100 mg/kg) a somato-sympathetic reflex increase of blood pressure and heart rate was evoked by electrical stimulation of sensory fibres running within the tibial nerve. i.v. injection of 30 microgram/kg of the alpha-adrenoceptor agonist clonidine caused a reflex inhibition in intact and vagotomized animals. in contrast, injection of 2 microgram/kg clonidine into the vertebral artery elicited hypotension but no reflux inhibition. in small doses, ... | 1978 | 23300 |
| relationship between the anionic structure of organic acids and the response of cat taste receptors. | with the aid of analysis of afferent impulse activity in the cat chorda tympani, it was shown that the effect of application of organic acids solutions of the same ph to the tongue could be represented as follows: propionic acid greater than lactic acid greater than pyruvic acid. these data confirm the suggestion that carboxylic acids without polar groups are the most effective, and an anion which has oh-group in alpha-position is more effective than an anion with keto-group. | 1978 | 23322 |
| the third thudichum lecture: some incidents in the search for chemical transmitters in the brain. | | 1977 | 23332 |
| inhibitory effects of methyl o-(4-hydroxy-3-methoxycinnamoyl) reserpate (cd-3400) on the central nervous system (author's transl). | effects of methyl o-(4-hydroxy-3-methoxycinnamoyl) reserpate (cd-3400) on the central nervous system in mice, rats and cats were investigated, and a comparison was made with such effects of reserpine and rescinamine. inhibitory effects of cd-3400 on spontaneous motor activity and conditioned avoidance response were weaker and shorter than those of reserpine and rescinnamine. in the experiments of the inhibitory effects of the central actions such as ptosis, hypothermia, decrease in motor ability ... | 1977 | 23346 |
| localization of substance p-like immunoreactivity in nerves in the tooth pulp. | the occurrence of substance p (sp)-like immunoreactivity was studied in dental pulps of the cat. in untreated animals sp-positive fibres were found in all areas of the pulp. most fibres were seen in central parts of the pulp but they were also observed in relation to the odontoblasts. single, possibly unmyelinated, or fine caliber fibres or small bundles of them were seen running close to large non-fluorescent myelinated nerves, to blood vessels or without any obvious association with either of ... | 1977 | 23511 |
| heptadecapeptide gastrin in the vagal nerve. | immunoreactive gastrin was present in vagal nerves from cats, dogs, and human beings. the abdominal portion of the vagus contained gastrin in amounts ranging from 16 to 273 pmol/g of nerve tissue (wet weight). the thoracic and cervical portion of the vagi contained only minute amounts of gastrin. gel chromatography of extracts of human, canine, and feline abdominal vagi monitored by region-specific antisera against heptadecapeptide gastrin and triacontatriapeptide cholecystokinin revealed that t ... | 1977 | 23537 |
| molecular mechanism of active calcium transport by sarcoplasmic reticulum. | | 1978 | 23557 |
| h+ transport: regulation and mechanism in gastric mucosa and membrane vesicles. | | 1978 | 23558 |
| balance-sheet after 5-years of beta-blocker use in psychiatry. general considerations on beta-active substances. | | 1977 | 23717 |
| intercellular junctions in the organ of corti. | the intercellular junctions between adjacent supporting cells and between apposed hair and supporting cells in the organ of corti of cat and human were studied. at the endolymphatic surface, the intercellular space was closed by a series of tight junctions (zonula occludens), whereas there were no tight junctions at the basilar membrane surface of the neuroepithelium. beneath the adlumenal zonula occludens between adjacent supporting cells, a zonula adherens (intermediate junction, "desmosone") ... | 1978 | 23719 |
| beta-adrenoceptor blockade with diphenylhydantoin (dph). | diphenylhydantoin (dph) (20 x 10(-6) to 80 x 10(-6) m/kg) blocked the depressor responses to isoproterenol in spinal, bilaterally vagotomized and atropine pretreated cats; depressor responses to histamine were unaffected; dph shifted the isoproterenol concentration-response curve to the right in isolated guinea pig tracheal chain preparation, isolated rabbit ileum and isolated perfused heart of frog. the results suggest that dph has a specific beta-adrenoceptor blocking action and the blockade a ... | 1977 | 23797 |
| release of noradrenaline from cat spleen slices by potassium. | 1 when cat spleen slices were exposed to a potassium-enriched (140 mm) krebs solution, 367 +/- 31 ng g-1 5 min-1 of noradrenaline (na) was released into the bathing medium. 2 phenylephrine and clonidine (10(-7) to 10(-3) m) did not significantly modify the potassium-evoked na release; acetylcholine decreased it in a dose-dependent manner. 3 phenoxybenzamine increased na release by 50% but phentolamine did not alter it; high concentrations of this drug greatly decreased na release. cocaine increa ... | 1978 | 23881 |
| lack of effect of hypercapnic acidosis on elasticity of cat papillary muscles. | chages in external ph from 7.40 to 6.95 obtained by changing the pco2 of the medium at constant bicarbonate concentration produced in cat papillary muscles a significant decrease in isometric tension with no changes in time to peak tension. active and resting stiffness, as determined by two different methods, did not change under conditions of hypercapnic acidosis. | 1977 | 23899 |
| actions of angiotensin on adrenergic nerve endings. | in the perfused vascular bed, vasoconstrictor responses to adrenergic nerve stimulation are augmented to a greater degree by angiotensin ii than are the responses to injected norepinephrine. overflow of adrenergic transmitter is also greater during nerve stimulation in the presence of angiotensin than in its absence. the evidence indicates that facilitation of adrenergic transmitter release rather than uptake blockade accounts for these results. in addition, an increased responsiveness of isolat ... | 1978 | 23967 |
| prostaglandins--modulation of adrenergic nervous system. | prostaglandins (pgs) affect vascular tone by a direct action on the vascular smooth muscle and by influencing vascular reactivity to adrenergic simuli and several vasoactive substances. thus, in the isolated tyrode's perfused rabbit renal, mesenteric and splenic vasculature pge2 inhibited adrenergically induced vasoconstriction. since the vasoconstrictor responses to renal nerve stimulation were enhanced by the blockade of pg synthesis and were reduced by stimulation of pg synthesis with arachid ... | 1978 | 23968 |
| effects of adrenoceptor stimulating and blocking agents on carotid body chemosensory inhibition. | 1. the effects of alpha- and beta-adrenoceptor agonists and antagonists on chemosensory discharges originating from carotid bodies in situ were studied in anaesthetized cats.2. noradrenaline (na) injections commonly resulted in increased frequency of carotid nerve chemosensory discharge, an effect ascribed to reduced blood flow through the glomus, and reduced or eliminated by alpha-adrenergic block.3. na injections occasionally produced an initial reduction of chemosensory discharge frequency, w ... | 1978 | 24116 |
| effects of sedatives and major tranquilizers on aggressive behavior. | | 1978 | 24172 |
| effects of stimulants on aggressive behavior. | | 1978 | 24174 |
| effect of narcotic analgesics on excitatory transmission in the spinal cord. | as demonstrated on nonanesthetized curare-immobilized spinal cats morphine, promedol and fentanyl failed to alter the amplitude of induced potentials in the ventro-lateral columns of the lumbar spinal cord, evoked by a single or repetitive stimulation of the cutaneous or pelvic nerves. in some experiments the same drugs inhibited the nerurons of the posterior horns of the spinal cord activated by the nociceptive stimulation of the peripheral receptors in intraarterial administration of bradykini ... | 1978 | 24487 |
| neurogenic vasodilation of cat cerebral arteries. | transmural nerve stimulation (tns) with 0.3-msec pulses between 1 and 25 hz dilated cat cerebral artery segments in the presence of active muscle tone. maximum vasodilatation occurred at 8 hz. the dilator response to exogenous acetylcholine, but not to tns, was abolished by atropine. neither physostigmine nor hemicholinium affected the dilator response to tns, which persisted after administration of guanethidine, phenoxybenzamine, propranolol, reserpine, and chronic sympathectomy. however, it wa ... | 1978 | 24505 |
| neurotransmitters responsible for visual perception. | | 1978 | 24758 |
| interactions of neurotransmitters. | | 1978 | 24762 |
| amino acids as transmitters: glycine, taurine and serine. | | 1978 | 24764 |
| tranquilizers and neurotransmitters. | | 1978 | 24769 |
| the role of fibrin formation in the pathogenesis of bacteremic shock in the primate. | in this study, an attempt was made to elucidate further the role of intravascular fibrin formation in the pathogenesis of sepsis in the primate. it was found that injected live escherichia coli caused death in primates within four to 11 hours as a result of microcirculatory failure and acidosis. pretreatment with arvin did not prolong the survival rate, probably because of an overloading of the reticuloendothelial system with fibrin degradation products. this study does not support an obligatory ... | 1978 | 24899 |
| dynamics of the neurohumoral reactions of the resistant and capacitive blood vessels of the skin and muscles in the process of adaptation to the high-altitude conditions of tien-shan. (1. reflex reactions). | | 1977 | 24960 |
| neuroleptic blockade of the effect of various neurotransmitter substances. | the antagonistic effect of neuroleptics to acetylcholine, histamine, 5-ht, and noradrenaline was examined in various in vivo and in vitro models. piflutixol, a new potent thioxanthene neuroleptic, markedly antagonizes the effect of dopamine, noradrenaline, 5-ht and to some extent histamine, whereas the affinity for muscarinic receptors was rather weak. clozapine and chlorprothixene on the other hand, have high affinity for muscarinic receptors and also antagonize the effect of histamine and 5-ht ... | 1978 | 24978 |
| physiology of the hippocampus and related structures. | | 1978 | 25041 |
| experimental studies of the specificity and aspecificity of a beta-adrenolytic agent, bunitrolol (kö 1366). | in basis of our experimental researches bunitrolol presented: a) beta-adrenolytic activity prevailingly at cardiac level (superior to propranolol and practolol) in respect to vascular, tracheal, bronchial, uterus, intestinal and metabolic level; b) beta-adrenergic intrinsic activity; c) local anesthetic activity; d) chinidino-like activity; e) antiarrhythmic activity; f) hypotensive activity with interferences at the level of vasomotor centres, of the barosensitive zones, of the renin secretion ... | 1978 | 25057 |
| experimental analysis of the cardiovascular effects of acebutolol, a drug with beta-adrenolytic activity. | in experiments at cardiovascular system level, acebutolol was found to possess beta-adrenolytic activity of cardioselective type associated with intrinsic beta-adrenergic, antiarrhythmic and anti-hypertensive activity. it was well tolerated systemically. | 1978 | 25058 |
| intestinal neuraminidase activity of suckling rats and other mammals. relationship to the sialic acid content of milk. | 1. the neuraminidase activity of homogenates of the mucosa of the middle and distal thirds of the small intestine of rats increased about 5-fold between birth and 4 to 8 days of age, and then gradually declined to the much lower adult activity by 24 days. no comparable changes occurred in the proximal third. 2. in 8-day-old rats, the neuraminidase activity of the middle and distal thirds of the small intestine was about 10 times greater than that of the proximal third, 20 times greater than that ... | 1978 | 25066 |
| effects of ph and flow rate on the release of 'bound' red cells from the splenic pulp. | on perfusion of isolated, denervated spleens with ringer solution, immature and abnormal red cells are released into the venous outflow much more slowly than normal mature cells, being delayed through adherence to fine structures of the red pulp (am. j. physiol. 231, 1665-1671 (1976)). evidence suggested that the rate at which such cells are released from the 'bound' state might depend on local ph and fluid shear rate within the pulp. therefore, the rate of washout for this slow component of red ... | 1978 | 25128 |
| effect of gardneria alkaloids on ganglionic transmission in the rabbit and rat superior cervical ganglia in situ. | | 1978 | 25140 |
| hypotensive and antihypertensive activity of a newly synthesized derivative of 2-aminotetralin. | the report describes the hypotensive and antihypertensive activity of the compound n-(trans-3-hydroxy-1,2,3,4-tetrahydro-2-naphtyl)-n'-(3-oxo-3-phenylpropyl) piperazine dihydrochloride (p11). the work is made on normotensive cats and rats as well as on spontaneous and experimental (metacorticoid) hypertension. the studies were carried out under the conditions of acute and chronic experiment as the arteria pressure was recorded by blood and bloodless method. the compound p11 show a manifested hyp ... | 1978 | 25170 |
| the effect of mainly alpha-adrenergic drugs, indirect sympathomimetrics and dopamine on exocrine pancreatic function. studies in the isolated cat pancreas (author's transl). | the influence of mainly alpha-adrenergic drugs (noradrenaline, adrenaline, phenylephrine), indirect sympathomimetics (ephedrine, tyramin) and dopamine on the exocrine pancreatic function of the isolated perfused organ of cats was studied. the injection of noradrenaline and adrenaline induced simultaneously a rapid depression of flow rate and an increase of perfusion pressure. phenylephrine, indirect sympathomimetic drugs and dopamine did not change the perfusion pressure and the hydrelatic funct ... | 1978 | 25465 |
| vigilance disorders in old age and the effect of rational drug therapy. neurophysiological and biochemical aspects of vigilance. | | 1977 | 25541 |
| cardiovascular actions of bromocriptine. | bromocriptine lowers blood pressure in animals and in man. results obtained in experiments performed in the dog and cat suggest three possible mechanisms of action: a) relaxation of vascular smooth muscle, principally in splanchnic and renal vessels, (b) inhibition of transmitter release from noradrenergic nerve endings, (c) central inhibition of sympathetic nerve activity. the effect of bromocriptine at each putative site of action can be explained in terms of dopamine receptor stimulation. | 1978 | 25553 |
| cytochemical demonstration of esterases in peripheral blood leukocytes. | cytochemical methods for alpha naphthyl acetate esterase and chloroacetate esterase have been used to identify human monocytes and granulocytes. in this study, a standard procedure for staining alpha naphthyl acetate and chloroacetate esterase activities was modified by extending the range of ph of the incubation mixture and the duration of staining and was applied to cat, dog, goat, guinea pig, hamster, human, pig, rabbit, rat, and sheep leukocytes. the results for both enzymes showed (1) incub ... | 1978 | 25603 |
| metabolism and toxicity of 2,2,2-trifluoroethyl vinyl ether. | a review on metabolism and toxicity of the fluorinated anesthetic agent, fluroxene, is presented. fluroxene anesthesia is nontoxic to man but fatal to many experimental animals. the fluroxene molecule (2,2,2-trifluroethyl vinyl ether) is composed of two moieties; both are toxic as a result of their metabolism: the vinyl moiety destroys heme of cytochrome p-450 while being metabolized to the final product, co2. the trifluoroethyl moiety is oxidized to trifluoroethanol (tfe) and trifluoroacetic ac ... | 1977 | 25763 |
| analysis of the mechanism of action of carbonic acid on tissue chemoreceptors. | perfusion of the small intestine of anesthetized cats with a solution imitating metabolic acidosis (ph = 7.3; hco-3 = =20.2 mm; pco2 = 38 mm hg) produced a threshold reflex increase in the blood pressure. the subsequent decrease of hco-3 to 3.2 mm and ph to 6.5 evoked a gradual raise of the blood pressure followed by a sharp increase of pressor reflexes amplitude within the range of ph 6.5--6.3. solutions imitating metabolic acidosis (ph = 7.1; hco-3 = 12.7 mm) were found to increase the concent ... | 1978 | 25790 |
| the hypertensive effect of adyston and etilefrin. comparative animal experimental studies. | according to the results obtained under the described conditions it can be stated that after i.v. administration adyston induces a dose-dependent rise in systolic and diastolic blood pressure, in comparison with etilefrin the new product adyston shows a greater potency in rising the systolic and diastolic blood pressure; adyston induced rise of blood pressure is in general of longer duration in comparison with that induced by etilefrin, it is interesting that in the dose of 0.01 mg/kg adyston in ... | 1978 | 25832 |
| anemia as a stimulus to aortic and carotid chemoreceptors in the cat. | in cats anesthetized with alpha-chloralose, the activities of aortic and carotid chemoreceptor nerves were measured during a control period and during anemia where the hematocrit was lowered in steps by dextran-for-blood exchange. with anemia there was a sustained nonlinear increase in firing of aortic chemoreceptors. there was a greater firing of aortic chemoreceptors for a given lowering of hematocrit from an initial low blood hematocrit than for a similar decrease in hematocrit from an initia ... | 1978 | 25859 |
| recent advance in neuropharmacology (author's transl). | | 1978 | 25972 |
| the mosaic of nerve cells in the mammalian retina. | | 1978 | 26058 |
| cerebral hemodynamics in arterial hypertension and hypertensive crisis under the influence of therapeutic blood pressure lowering. | | 1977 | 26151 |
| therapy of hypertension. i. new antihypertensive agents, pharmacologic and pharmacokinetic bases. beta-adrenergic blockers and blood pressure lowering. | | 1977 | 26152 |
| oxygen consumption and oxygen extraction of the feline liver under different types of induced hypoxia. | | 1977 | 26181 |
| flow stasis, blood gases and glucose levels in the red pulp of the spleen. | | 1977 | 26183 |
| intestinal o2 consumption under low flow conditions in anaesthetized cats. | | 1977 | 26184 |
| extracellular k+ and h+ activities in the brain cortex during and after a short period of ischaemia and arterial hypoxia. | | 1977 | 26187 |
| regional hemodynamic and metabolic alterations in focal cerebral ischemia: studies of diaschisis. | | 1977 | 26188 |
| modulation of autonomic correlates of emotional stress and adaptive responses. | the character and dynamics of the cardio-vascular response to psychogenic stress (confrontation of cat and dog) depends on active or passive type of behavioral response. tranquilizers inhibit long-lasting hypertension otherwise occurring after the stress stimulus. adaptive cardio-vascular responses and baroreceptor reflexes did not alter after tranquilizers administration. effects of psychotropic drugs correspond to the type of individual behavioral response. | 1978 | 26611 |
| effect on the cushing response of different rates of expansion of a supratentorial mass. | the effects on the three components (respiration, blood pressure, and heart rate) of the cushing response (cr) were studied in cats by the continuous expansion of a supratentorial balloon. the rate of expansion was varied over the range of 0.006 to 0.6 ml/min, during whic systemic arterial pressure, heart rate, respiratory rate, and blood gases were monitored. for the different rates the time the cr took to develop, and the balloon volume required for that development were measured. the final vo ... | 1978 | 26734 |
| studies with brugia pahangi 17. the anthelmintic effects of diethylcarbamazine. | diethylcarbamazine (dec) was active in vitro against infective larvae and microfilariae of brugia pahangi but only at high concentrations. when fed to mosquitoes which were infected with b. pahangi it had little or no activity. in jirds it was inactive against b. pahangi microfilariae and adults when administered at 300 mg/kg for 5 days either by the intraperitoneal or oral route. in cats given 25 or 50 mg dec/kg intraperitoneally on 3 or 5 occasions it was not microfilaricidal, but most of the ... | 1978 | 26737 |
| actions of procaterol (opc-2009), a new beta2-adrenoceptor stimulant, on pulmonary resistance, contractions of the soleus muscle, and cardiovascular system of the anaesthetized cat. | | 1978 | 26738 |
| relation between baseline firing rate and the direction of neuronal responses to noradrenaline: a species comparison. | | 1978 | 26779 |
| the action of enkephalins and enkephaline analogues on neuro-transmission in the isolated nicititating membrane of the cat. | | 1978 | 26780 |
| fundamental research on the pharmacological activity of oriental drugs. xii. pharmacological research on beta-adrenergic potentiation factors included in musk and their organ-selective activity (author's transl). | | 1978 | 26784 |
| beneficial effects of alkalotic reperfusion following ischemic cardiac arrest. | | 1978 | 26825 |
| a basis for migraine therapy- the autonomic theory reappraised. | the concept that migraine results from an initial vasoconstriction due to increased release of noradrenaline from the sympathetic nerves to cranial blood vessels has been reappraised in the light of recently acquired knowledge of the mechanisms of action of drugs used in the treatment of migraine, physiological and pharmacological evidence implicating noradrenaline, and the observations by others that several migraine variants may be associated with some degree of sympathetic overactivity. if th ... | 1978 | 26908 |
| the influence of low, normal and high pa(o2) on the respiratory effects of pa(co2) oscillations in anaesthetised cats. | the present study examines the influence of oxygen tension on the recurrent tidal volume changes caused by oscillations in arterial p(co2). the oscillations have a period equal to two respiratory cycles, and are produced by giving alternately co2 -enriched and co2 -free gas mixtures. the results show alternation of the tidal volume with the same incidence (is greater than 50%) at low, normal and high oxygen tensions. however, the magnitudes of the breath-by-breath changes are significantly great ... | 1978 | 26944 |
| identification of beta-adrenoceptors and histamine receptors in the cat nasal vasculature. | the responses of the nasal capacitance vessels of the cat were recorded following intra-arterial injections of beta-adrenoceptor agonists and histamine h1-and h2-receptor agonists. isoprenaline evoked vasodilation and propranolol (beta-adrenoceptor antagonist) caused a parallel shift to the right of the isoprenaline log dose-response curve. histamine, 2-(2-aminoethyl)pyridine (h1-agonist) and 4-methylhistamine (predominantly h2-agonist) all evoked vasodilation. metiamide (h2-antagonist) produced ... | 1978 | 27057 |
| lipid metabolism by the gall-bladder. ii. the in vitro conversion of lysophosphatidylcholine to phosphatidylcholine. | lysophosphatidylcholine acyltransferase, which catalyzes the acylation of lysophosphatidylcholine with fatty acid coenzyme a to form phosphatidylcholine, was assayed in gall-bladder mucosa. in guinea pig gall-bladder the activity parallels that of the microsomal enzyme, glucose-6-phosphatase with 3--4-fold enrichment of the activity in the microsomes. studies with saturated and unsaturated substrates demonstrated highest activity when oleoyl coenzyme a and palmitoyl lysophosphatidylcholine were ... | 1978 | 27225 |
| pharmacology of azidomorphine. | as revealed, in acute experiments on rabbits, cats, and rats, a new morphine-like synthetic analgesic drug azidomorphine exceeded 20--100-fold the morphine ability to inhibit synaptic transmission in the thalamic structures, cerebral cortex, and the spinal cord during the nociceptive stimulation, and also by its analgesic activity. | 1978 | 27263 |
| alteration of medullary respiratory unit discharge by iontophoretic application of putative neurotransmitters. | 1 cats with midcollicular decerebration were vagotomized, paralyzed and artificially ventilated. phrenic nerve activity was recorded as an index of central respiratory rhythm. medullary respiratory neurones and non-respiratory cells located in approximation to the ventral respiratory nucleus were tested for their responsiveness to iontophoretically applied gamma-aminobutyric acid (gaba), acetylcholine (ach) and glutamate. 2 gaba tended to inhibit, whereas ach and glutamate excited activity both ... | 1978 | 27271 |
| factors limiting the rate of termination of the neuromuscular blocking action of fazadinium dibromide. | 1 reasons for the termination of the neuromuscular blocking action of fazadinium dibromide have been investigated. 2 in the anaesthetized cat, maximum neuromuscular block of tibialis anterior muscle twitches following rapid intravenous injection of fazadinium was obtained as the injection bolus passed through the muscle, indicating the fazadinium very readily crosses capillary membranes. 3. the half-life of plasma clearance of fazadinium was about 1 min in both cat and man, despite a 10 fold dif ... | 1978 | 27272 |
| the use of kainic acid in the localization of enzymes in the substantia nigra. | the selective destruction of neuronal perikarya via intracerebral injections of kainic acid was used to elucidate the cellular location of four neurotransmitter-related enzymes in the substantia nigra (sn). two weeks after intranigral injections of kainic acid, dopamine-sensitive adenylate cyclase, glutamic acid decarboxylase (gad), choline acetyltransferase (cat) and acetylcholinesterase (ache) were measured in the sn. histological examination of the sn, and a reduction of striatal tyrosine hyd ... | 1978 | 27284 |
| capillary flow in the brain cortex during changes in oxygen supply and state of activation. | | 1978 | 27338 |
| the significance of cortical extracellular h+, k+ and ca2+ activities for regulation of local cerebral blood flow under conditions of enhanced neuronal activity. | | 1978 | 27342 |
| effectiveness of pyridostigmine in reversing neuromuscular blockade produced by soman. | the effects of pyridostigmine pretreatment on the neuromuscular blockade produced by soman in anaesthetized, atropinized animals have been studied on the soleus and anterior tibialis muscle (rhesus monkeys, cats and rabbits) and the gastrocnemius muscle (guinea-pigs and rats). pyridostigmine pretreatment produced a complete recovery of neuromuscular function following blockade by soman; the rate of recovery was similar in all the species, suggesting a common mechanism of action. in the absence o ... | 1978 | 27607 |
| alteration of relative affinities toward myocardial and vascular beta adrenoceptors induced by side-chain substitution of aryloxypropanolamines. | | 1978 | 27636 |
| comparison of the cardiotoxic effects of carbromal, bromisoval and pentobarbital. | | 1978 | 27695 |
| feline cystitis, urethritis, urethral obstruction syndrome. part iii. prophylaxis. | | 1978 | 27715 |
| interaction of peripheral and central respiratory drives in cats. i. effects of sodium cyanide as a peripheral chemoreceptor stimulus at different levels of csf ph. | in cats anesthetized with chloralose-urethane, the central respiratory chemoreceptors were exposed to mock csf of ph 7.02, 7.02, or 7.57. the right carotid body was simultaneously stimulated by intracarotid injections of 40, 80, or 160 microgram sodium cyanide in 200 microliter ringer solution. the left carotid nerve and, in some animals, both vagosympathetic truncs were dissected. it could be demonstrated that the increase in ventilation produced by application of nacn to the peripheral chemore ... | 1978 | 27752 |
| gastric acid secretion by vagal electrostimulation (author's transl). | in the operative verification of vagotomy, electrical stimulation of the vagus nerves with the study of ph should seem to be a reliable method. on the basis of an experiment in the cat, the authors emphasise the effectiveness of electrical stimulation of gastric acid secretion, confirmed by 16 clinical cases. stimulation of the proximal end of the divided right nerve may be used to detect a nervous strand arising above the level of the section and to confirm the completeness of left vagotomy. | 1978 | 27756 |
| the ferrier lecture, 1977. the neuron network of the cerebral cortex: a functional interpretation. | | 1978 | 27801 |
| neuropharmacological profile of clobazam, a new 1',5'-benzodiazepine. | the effect of the new 1,5-benzodiazepine clobazam on visual evoked potentials (vep) and spontaneous eeg in the conscious rabbit and on spinal polysynaptic reflexes in the decerebrated cat was studied in comparison to the 1,4-benzodiazepine diazepam. clobazam was half as potent as diazepam in depressing the amplitude of visual evoked potentials in the nonanaesthetized rabbit, whereas the depressing effect on spinal polysynaptic reflexes in the decerebrated cat was only 1/7 --1/30 of the diazepam ... | 1978 | 27836 |
| emotional stress, anxiety and neurotransmitters (author's transl). | | 1978 | 27841 |
| intracellular buffering. | in the quantification of buffering the distinct roles of bicarbonate and of other buffers must be taken into account. the determination of the total non-bicarbonate buffer value, betaa, in intact tissues is complicated by active ph regulation and by heterogeneity of cytoplasm with respect to betaa, while heterogeneity with respect to ph in vivo could cause errors in estimates made with homogenates. available estimates of betaa are discussed, as are the individual contributions of proteins, dipep ... | 1978 | 27854 |
| the oh-/h+ concept of acid-base balance: historical development. | | 1978 | 27858 |
| psychophysiologic characteristics of the individual psychotropic activity of benzodiazepine derivatives under experimental conditions. | in 156 experiments performed on 41 cats with adequate experimental models of pseudoneurotic conditions, states of anxiety due to an electrostimulation of the hypothalamus through implanted electrodes and an emotional stress due to a conflict situation the authors compared the individual traits of the psychotropic activity of lorazepam, diazepam, chlordiazepoxide, oxazepam, nirazepam. these experiments permitted to display significant differences of psychophysiological structures in the tranquili ... | 1978 | 27927 |
| actual knowledge on beta blocking agents in psychiatry (author's transl). | a new group of substances blocking central beta receptors, ie beta blocking agents among which oxprenol and pindolol, have been used in psychiatry, mainly in anxious or depressive-anxious patients. the anxiolytic effect, particularly on somatic anxiety, is interesting, and is present in double blind studies with benzodiazepines, where it is superior to these classical agents. the author has observed this therapeutic activity in series of one hundred patients and also a dynamising effect in some ... | 1978 | 27946 |
| increased tissue water in the brain: influence on regional cerebral blood flow and oxygen supply. | | 1978 | 27959 |
| reactions of pial vessels to acute arterial hypertension at various levels of arterial ph and carbon dioxide tension. | | 1978 | 27960 |
| actions and interactions of cations and anions on pial arteries. | | 1978 | 27961 |
| behavior of extracellular h+ and k+ activities during functional hyperemia of microcirculation in the brain cortex. | | 1978 | 27962 |
| effect of respiratory drugs on mucociliary clearance. | | 1978 | 28211 |
| the influence of heart rate on ouabain cardiotoxicity in cats with spinal cord transection. | the dose, serum level and ventricular content of ouabain needed to produce cardiotoxicity were examined in control cats, cats with transected spinal cords and cats with transected spinal cords whose heart rates were restored to control values by artificial pacing. the lethal dose of ouabain was higher in cats with transected spinal cords and not paced than it was in the control group. however, the lethal dose of ouabain in spinal-sectioned cats with ventricular pacing was no different from that ... | 1978 | 28234 |
| neuronal responses to amino acid iontophoresis in the deafferented spinal trigeminal nucleus. | | 1978 | 28244 |
| brain ph measurements using a diffusible, lipid soluble ph sensitive fluorescent indicator. | | 1978 | 28382 |
| pharmacology of 6,7-dihydroxy-2-dimethylaminotetralin (tl-99). i. cardiovascular activity in the dog and cat. | 6,7-dihydroxy-2-dimethylaminotetralin (tl-99), the 5,6-dihydroxy isomer (m-7) and dopamine were studied for cardiovascular activity in the cat and dog. tl-99 was found to be the most active of these compounds. some of the more striking actions of tl-99 and m-7 were bradycardia, hypotension and complete blockade of norepinephrine-induced reflex activation. a detailed study of these compounds showed that they were most likely exerting their effects by inhibiting sympathetic nervous system activity ... | 1978 | 28414 |
| effects of two adrenergic beta-receptor blockers on the sleep cycle of the cat. | sixteen hour polygraphic recordings (eeg, eog and emg) were obtained from 14 adult cats after intraperitoneal injections of propranolol (5 mg/kg) or pindolol (0.1 or 0.5 mg/kg). all injections moderately increased waking, which consisted mainly of a sedated drowsy stage. both drugs also decreased deep slow wave sleep, while light slow wave sleep remained at control levels. the changes were more marked after propranolol, which also significantly reduced paradoxical sleep (ps). the decrease in the ... | 1978 | 28454 |
| the positive inotropic effect of phenylephrine in the presence of propranolol. increase in time to peak force and in relaxation time without increase in c-amp. | the effects of phenylephrine on the shape of the contraction curve and on the cyclic adenosine 3',5'-monophosphate (c-amp) content were studied in electrically driven (frequency 0.2 hz) cat papillary muscles. all experiments were done in the presence of 1 micron propranolol in order to minimize interference from beta-adrenoceptors. 1. phenylephrine increased the force of contraction in a concentration-dependent manner. maximal effects (about 200% of control) occurred at 30 micron phenylephrine. ... | 1978 | 28486 |
| mechanism of the enhancement in transmitter release from central and peripheral noradrenergic nerve terminals induced by the purified scorpion venom, tityustoxin. | | 1978 | 28487 |
| action and interaction of perivascular h+, k+ and ca++ on pial arteries. | in cats the perivascular space of small pial arteries was perfused with mock csf by means of micropipettes. variations of k+, h+ and ca++ activities in the perfusate cause changes of the diameters of the affected vessels. increases of h+ and moderate increases of k+ lead to dilatations, ca++ -increases elicit constrictions. the ions interact in such a way that perivascular ca++ inhibits the k+ or h+ induced dilator response of the pial arteries. alkalosis intensifies the constrictor action of ca ... | 1978 | 28512 |
| pharmacologic differentiation between various anti-arrhythmics in animal experiments. | | 1978 | 28644 |
| evaluation of continuous monitoring of tissue ph in cats. | an improved continuous tissue ph monitoring system, designed for human subcutaneous fetal scalp tissue, was evaluated in 10 cats for total of 60 hours. respiratory acidosis was induced with and without hypoxia to model the pathology of human clinical fetal distress. arterial and venous ph were sampled every 15 minutes and the values were compared to those from the ph monitor system. the values paralleled arterial and venous blood ph, with correlation coefficients up to 0.98 under various patholo ... | 1978 | 28671 |