| variations in structure and function during the life cycle of malarial parasites. | the fine structure of malarial parasites is reviewed and the function of the intracellular organelles is discussed. when the erythrocytic, exoerythrocytic, and mosquito stages of plasmodia are compared, substantial differences are seen. the major differences involve the amount of surface coat of the motile forms, the structure and function of the mitochondria, and the ingestion and digestion of nutrients. significant structural differences are also observed between comparable stages of mammalian ... | 1977 | 338177 |
| invasion and growth of plasmodium falciparum in different types of human erythrocyte. | the susceptibility of human red blood cells to invasion by plasmodium falciparum was investigated in microtissue cultures with different populations of erythrocytes containing fetal haemoglobin (hbf). preferential invasion of hbf-containing erythrocytes was observed with umbilical cord blood. the parasites showed no preference for hbf cells in blood from a subject with hereditary persistence of fetal haemoglobin (hpfh). by contrast, a significant preference for hba-containing erythrocytes was fo ... | 1977 | 338178 |
| a histidine-rich protein from plasmodium falciparum and its interaction with membranes. | in previous studies, an unusual protein with 70% of histidine was isolated from plasmodium lophurae. it was shown to have a possible function in the penetration of merozoites into erythrocytes. the results of the present study indicate the presence of a similar histidine-rich protein in plasmodium falciparum. like that of p. lophurae, the histidine-rich protein of p. falciparum is acid-soluble, but it has a slightly higher molecular weight. | 1977 | 338179 |
| transport of amino acids and nucleic acid precursors in malarial parasites. | in vitro studies have shown that exogenously supplied amino acids are transferred into the malaria-infected cell, where they are incorporated into proteins. most amino acids appear to enter the cell by facilitated or simple diffusion; however, the high distribution ratios seen in plasmodium knowlesi-infected cells are difficult to explain on this basis. the changes (leakiness) observed in amino acid transport in p. lophurae infected cells are probably the result of atp depletion in the host cell ... | 1977 | 338180 |
| carbohydrate metabolism of malarial parasites. | the evidence for the pathways involved in the metabolism of carbohydrates by malarial parasites is critically reviewed. in all species studied, glucose is catabolized mainly by glycolysis with little participation of the pentose-phosphate pathway. it has not been proved conclusively that there is a functioning citric acid cycle in the intraerythrocytic stages of avian plasmodia, nor is it certain that these stages of any malarial parasites use oxygen. | 1977 | 338181 |
| isolation and analysis of nucleotides from erythrocyte-free malarial parasites (plasmodium berghei) and potential relevance to malaria chemotherapy. | studies using erythrocyte-free preparations of p. berghei were conducted with a view to improving knowledge of parasite metabolism, particularly nucleotide metabolism. the free parasites employed in these studies were prepared by saponin lysis of parasitized mouse erythrocytes in isotonic glucose solutions. a comparative study of post-lytic metabolic activity of free parasites prepared by saponin, ammonium chloride, or osmotic lysis indicated a significantly greater retention of metabolic activi ... | 1977 | 338182 |
| amino acid metabolism and protein synthesis in malarial parasites. | malaria-infected red cells and free parasites have limited capabilities for the biosynthesis of amino acids. therefore, the principal amino acid sources for parasite protein synthesis are the plasma free amino acids and host cell haemoglobin. infected cells and plasmodia incorporate exogenously supplied amino acids into protein. however, the hypothesis that amino acid utilization (from an external source) is related to availability of that amino acid in haemoglobin is without universal support: ... | 1977 | 338183 |
| folate metabolism in malaria. | it is known that malaria parasites are inhibited by sulfonamides and antifolate compounds, require 4-aminobenzoic acid for growth, and respond only partly to intact folic and folinic acids. biochemical data obtained during the last decade on the synthesis of nucleic acid precursors and on folate enzymes in malaria support the hypothesis that malaria parasites are similar to microorganisms that synthesize folate cofactors de novo. sulfa drugs inhibit plasmodial dihydropteroate synthase (ec 2.5.1. ... | 1977 | 338184 |
| ultrastructure and viability of cryopreserved plasmodium falciparum. | cryopreserved chimpanzee erythrocytes infected with plasmodium falciparum were examined by electron microscopy directly and after a period of culture. light microscopic observations on the viability of cryopreserved parasites in culture were also made. parasitaemia data from a chimpanzee infected with parasites cryostored for more than 2(1/2) years are presented. varying degrees of damage were apparent as the parasites were examined in vitro, for viability, and by electron microscopy. schizonts ... | 1977 | 338185 |
| the isolation and fractionation of malaria-infected cells. | this paper is a critical review of procedures for the isolation of malarial parasites from host cells and their fractionation. the procedures are grouped according to the stage of parasite being isolated, and the procedures for isolation of the erythrocytic stages are further grouped by techniques used. some types of procedure are described for isolation of all stages of the parasite, both those in the invertebrate and vertebrate hosts. the uses and limitations of the various procedures are desc ... | 1977 | 338186 |
| cultivation of erythrocytic stages. | two methods are described for the continuous cultivation of plasmodium falciparum. one method provides for a continuous slow flow of medium over a settled layer of blood cells and does not require daily attention. with the other method, carried out in petri dishes, the medium has to be changed manually every day. the problems and possibilities of continuous cultivation are discussed. | 1977 | 338187 |
| population studies of plasmodium vivax. 1. the theory of polymorphism of sporozoites and epidemiological phenomena of tertian malaria. | the understanding of clinico-epidemiological phenomena of tertian malaria has been the subject of controversy. the authors suggest a system of postulates which give a non-contradictory explanation of the phenomena of relapses and long incubation. the main idea is that the duration of exoerythrocytic development of plasmodium vivax is a polymorphic characteristic controlled by a set of genes. according to these postulates sporozoites may be subdivided into two groups designated as tachysporozoite ... | 1977 | 338188 |
| population studies of plasmodium vivax. 2. distribution of manifestations in foci of tertian malaria. | the authors investigate a mathematical model based on the theory they proposed in a previous publication. the model fits field data collected in re-established foci of tertian malaria. the patterns of distribution of manifestations of tertian malaria among the population may readily be explained on the basis of the theory of polymorphism of sporozoites. | 1977 | 338189 |
| gametogenesis in culture by gametocytes of plasmodium falciparum. | | 1977 | 339101 |
| the duffy blood group and malaria prevalence in gambian west africans. | erythrocytes from 1,168 donors, comprising almost the entire populations of two rural gambian villages, have been tested for duffy blood group antigens using antisera to both fya and fyb. all tests were negative. blood film examination of the same samples showed complete absence of plasmodium vivax parasitaemia, but infections with p. falciparum,p. malariae and p. ovale were observed. the findings are consistent with the view that the duffy-negative phenotype, fyfy, constitutes the basis of inna ... | 1977 | 339418 |
| the treatment of severe falciparum malaria. | in severe falciparum malaria there is a pathophysiological cascade beginning with changes in the parasitized red blood cells which induce intermediate effects, in turn contributing to dysfunction of several organs. a low serum albumin is a common but often unrecognized finding which may contribute to oedema especially in the lung and brain. the only irreversible complication in falciparum malaria is the acute respiratory distress syndrome, manifested by cyanosis and rapid breathing, basically di ... | 1977 | 339421 |
| plasmodium malariae in kerala and tamilnadu states of india (1969--75) | | 1977 | 339425 |
| incubation and prepatent periods of plasmodium vivax. | | 1977 | 339427 |
| comparison of treatment schedules for plasmodium vivax infections in the solomon islands. | a total of 26 patients infected with solomon islands strains of plasmodium vivax was treated with one of three regimens of cloroquine-primaquine, in an attempt to determine the relapse patterns and the response to treatment of the local strains of parasite. the results suggest that the standard course of chloroquine-primaquine provides a radical cure for the strains of plasmodium vivax from the solomon islands, provided that strict supervision of drug administration is enforced. | 1977 | 339599 |
| diet and cerebral malaria: the effect of famine and refeeding. | in an outbreak of plasmodium falciparum malaria following refeeding after famine cerebral malaria was restricted to children eating grain. nomad children consuming a predominantly milk diet were free of this complication despite an equivalent incidence of uncomplicated malaria. freedom of nomads from cerebral complications may be due to inhibition by the milk diet of rapid division of the parasite combined with delayed recovery after famine of t cell function. | 1978 | 339705 |
| the seroepidemiology of malaria in middle america. iv. passage of malaria antibodies from mothers to infants. | in an area of el salvador moderately endemic for malaria, use of the indirect fluorescent antibody test (ifa) showed that 44% of the infants born to mothers who had ifa responses to plasmodium vivax of 1:20 or higher during the latter part of their pregnancy had positive ifa responses of 1:10 or higher to this antigen. no serum from an infant was positive in the absence of some level of malarial response in the mother. | 1977 | 339753 |
| chemosuppressive field trials in thailand. iii. the suppression of plasmodium falciparum and plasmodium vivax parasitemias by a sulfadoxine-pyrimethamine combination. | | 1977 | 339754 |
| in vivo and in vitro studies of chloroquine-resistant malaria in thailand. | fourteen patients infected with falciparum malaria admitted to the hospital for tropical diseases in bangkok, faculty of tropical medicine, mahidol university, were studied. in vivo and in vitro methods were used to compare the effects of chloroquine on plasmodium falciparum. the results showed that ri in vivo corresponded to samples containing chloroquine base 2.5-3.5 millimicromoles per ml of blood in vitro and rii in vivo corresponded to samples with chloroquine base of 4.0 millimicromoles pe ... | 1977 | 339855 |
| the chemotherapy of rodent malaria, xxvii. studies on mefloquine (wr 142,490). | mefloquine (wr 142,490) is a potent blood schizontocide active against drug-sensitive and drug-resistant lines of plasmodium berghei. the ed50 and ed90 against the p. berghei n strain in albino mice are 1.5 and 3.8 mg/kg respectively. the highly chloroquine-resistant rc line is less sensitive and mefloquine is not fully effective at the maximum tolerated dose in the '4-day test'. mefloquine has a similar mode of action to quinine both in vitro and (as demonstrated by the morphological changes it ... | 1977 | 339856 |
| the chemotherapy of rodent malaria, xxviii. the development of resistance to mefloquine (wr 142,490). | | 1977 | 339857 |
| studies on parasitic crisis in malaria: i. signs of impending crisis in plasmodium berghei infections of the white rat. | white rats infected with plasmodiam berghei were observed throughout the course of infection for indicators of impending crisis (penultimate stage). two ratios, percentage young compact forms:percentage trophozoites and percentage reticulocytes:percentage parasitaemia, were reliable markers of the penultimate period and impending crisis. when the percentage young compact form:percentage trophozoite ratio exceeded 1.0 and was coincident with an increase of uninfected reticulocytes in the circulat ... | 1977 | 339858 |
| antimalarial activity of s-isobutyl adenosine against plasmodium falciparum in culture. | | 1978 | 340273 |
| [connatal malaria (author's transl)]. | a case of connatal malaria due to plasmodium vivax in a newborn of turkish origin is presented. most likely the infection was acquired by materno - fetal transfusion during labor. pathophysiological aspects and mode of transmission of this rare disease are discussed. | 1977 | 340774 |
| prevalence of erythrocyte g6pd deficiency in sabah. | | 1977 | 340882 |
| malaria in a honduras hunter. | | 1978 | 341334 |
| the course of a plasmodium berghei infection in six different mouse strains. | | 1977 | 341557 |
| malaria cases observed in gdańsk in 1973-1977. | | 1977 | 342009 |
| the immunological response of cba mice to p. yoelii. ii. the passive transfer of immunity with serum and cells. | cba mice infected with the malaria parasite plasmodium berghei yoelii (p. yoelii) develop a self-resolving infection lasting 15-18 days; on recovery from a primary infection they are immune to further infection. cell and serum transfers from immune to non-immune mice were used to analyse the mechanism of resistance. whereas serum from mice which had recovered from a single infection was ineffective in transferring immunity, hyperimmune serum (from mice repeatedly challenged with p. yoelii) prote ... | 1978 | 342396 |
| demonstration of the role of cytophilic antibody in resistance to malaria parasites (plasmodium berghei) in rats. | this paper reports the results of a study of the nature of the immune response against plasmodium berghei parasites by inbred rats. a macrophage-cytophilic antibody specific for malarial antigens was identified and characterized. detection of the antibody on the macrophage surface was accomplished by the parasite adherence tests and by the indirect fluorescent antibody technique. isolation and purification of the macrophage-cytophilic and opsonic antibodies from hyperimmune rat serum was accompl ... | 1978 | 342408 |
| chloroquine resistant plasmodium falciparum in thailand: susceptibility of anopheles. | | 1977 | 342649 |
| column separation of plasmodium berghei sporozoites. | | 1978 | 342682 |
| synthesis of pyrimido[5,4-c]quinolines and related quinolines as potential antimalarials. | 3-ethylaminomethyl-2-methyl-4(1h)-quinolone (1a) and its 6-ch3, 6-och3, and 7-cl derivatives were prepared by means of the mannich reaction. conversion to the 4-chloro derivatives and condensation with 3-chloroaniline gave the corresponding 4-(3-chloroanilino) derivatives. cyclization of 4-(3-chloroanilino)-2,6-dimethyl-3-ethyl-aminomethylquinoline (3a) and its 6-och3 derivative with paraformaldehyde gave 1-(3-chlorophenyl)-3,9-dimethyl-3-ethyltetrahydropyrimido[5,4-c]quinoline (4a) and the 9-oc ... | 1978 | 342694 |
| response of falciparum malaria to a standard regimen of chloroquine in vientiane, lao people's democratic republic. | | 1977 | 342718 |
| [use of the serological methods in malariology (review of the literature)]. | | 1977 | 342893 |
| [malaria prophylaxis]. | | 1978 | 342981 |
| [clinical problems in current malaria. considerations apropos of 2 cases]. | two cases of malaria imported from west africa by two sailors (falciparum and vivax respectively) are reported. it is pointed out that nowadays malaria is no longer indigenous to sicily but has to be imported; an increasing number of cases of malaria are being reported world-wide in relation to increased traffic volumes, particularly air traffic. this means growing importance of imported pathology for which a new training strategy is required (with regard to young physicians who at present are q ... | 1978 | 342993 |
| [recrudescence of imported malaria (author's transl)]. | in the light of two recent cases of severe central nervous system malaria due to neglect in chemoprophylaxis, the authors report the very marked recrudescence in imported malaria and draw attention to the frequency of cases due to p. falciparum, the agent of malignant tertian fever and of malignant episodes. the necessity of early diagnosis in such cases is mentioned, together with the treatment of simple malaria and, in particular, of malignant varieties. in order to be effective, chemoprophyla ... | 1977 | 343066 |
| cell mediated and humoral immunity in experimental plasmodium berghei infection. | adoptive passive transfer of immunity to plasmodium berghei infection has been investigated in an inbred strain of swiss mice. the mice were made hyperimmune by repeated passage of 10(3) parasites and subsequent therapy with an antimalarial drug. immune sera and cells obtained from thymus, spleen and peritoneal exudate were transferred to normal animals which were subsequently challenged with standard doses of p. berghei. it was observed that: (a) immune serum in high doses (0.5 ml/mouse) enhanc ... | 1977 | 343309 |
| plasmodium falciparum gametocytes: the effect of chloroquine on their development. | asexual erythrocytic parasites of plasmodium falciparum are killed by chloroquine, whilst mature gametocytes are not. the gametocytes of p. falciparum take 10 days to develop to maturity and their sensitivity to chloroquine during this time was studied in vitro to investigate when the switch from susceptibility to insusceptibility occurred and to compare the responses of asexual and immature sexual parasites to the drug. 45 to 50% of asexual parasites and immature gametocytes less than one day o ... | 1977 | 343314 |
| a simplified method for in vitro production of schizonts of primate malarias useful as antigen in serologic tests. | | 1977 | 343315 |
| chemoprophylaxis and malaria in american servicemen returning from vietnam. | information relating to chemoprophylaxis and malaria in 49 men who served with the united states armed forces in vietnam and who developed overt malaria after departure from vietnam indicated that: 1) compliance with intended chemoprophylactic regimens was far optimal; 2) a history of recent prophylactic ingestion of chloroquine was not a reliable indicator of infection with chloroquine-resistant plasmodium falciparum: 3) reported ingestion of half or more of an intended terminal chemoprophylact ... | 1978 | 343607 |
| babesia microti infection in man: evaluation of an indirect immunofluorescent antibody test. | an indirect immunofluorescent antibody test was used to detect antibody to babesia microti in human sera. nine patients from nantucket island, massachusetts infected with b. microti had serum titers greater than or equal to 1,024. of 84 control sera from new york city residents, 246 sera from patients with possible exposure to ticks, and 36 sera from patients with suspected or confirmed tick bites, none was reactive at titers of 1:16 or above. the within-test reproducibility was within one fourf ... | 1978 | 343608 |
| plasmodium falciparum: responses of a semi-immune individual to homologous and heterologous challenges, and non-infectivity of gametocytes in anopheles stephensi. | with strict adherence to ethical guidelines, a semi-immune volunteer was exposed to homologous and heterologous blood challenges with strains of plasmodium falciparum from vietnam and tanzania. on both occasions infections developed, but clinical manifestations were moderated, prepatent periods increased, and parasitemias limited. gametocytes produced by these infections failed to infect anopheles stephensi. possible reasons for this are discussed. | 1978 | 343609 |
| an unusual macular lesion associated with malaria. | a case of a young man afflicted with falciparum malaria is presented in which the primary ocular finding was a subpigment epithelial hemorrhage involving the macula. previous reports in the literature concentrate on peripheral and central retinal hemorrhages, almost to the exclusion of choroidal vascular abnormalities. the value of this case lies in the recognition that the choroid can assume an important role in fundus abnormalities associated with malaria, probably on the basis of obstructive ... | 1977 | 343689 |
| immunity to plasmodium berghei in rats: reduced protective activity of immune spleen cells when transferred to recently infected rats. | | 1978 | 345537 |
| [morphologic changes in erythrocytes following the penetration and intra-erythrocyte development of plasmodium berghei in the mouse]. | | 1977 | 345925 |
| clinical and hematologic peculiarities of malaria in infancy. a study of 40 infants. | | 1978 | 346290 |
| response of p. vivax and p. falciparum cases to presumptive treatment with chloroquine in some districts of karnataka. | | 1977 | 346479 |
| regional depression of delayed hypersensitivity to sheep erythrocytes in mice infected with plasmodium berghei (nk65). | | 1978 | 347045 |
| amino acid analogs iv:4-fluoroisoleucine. | 4-fluoroisoleucine was produced by ammonolysis of 2-bromo-4-fluoro-3-methylpentanoic acid, which resulted from the bromofluorination of 4-methyl-2-pentenoic acid. it did not inhibit plasmodium berghei in mice at 640 mg/kg and was not toxic to the animals. the fluoroamino acid inhibited aspergillus niger, trichoderma viride, myrothecium verrucaria, trichophyton mentagrophytes, and mucor mucedo in czapek solution agar at a concentration between 10(4) and 10(3) microgram/ml. growth of escherichia ... | 1978 | 347050 |
| immunopathological studies of plasmodium berghei berghei-infected mice: effect of cyclophosphamide. | | 1978 | 347101 |
| studies of immunoglobulin m and malarial antibodies in nigerians. | measurements of immunoglobulin m, in 111 healthy adult nigerians have been presented. igm values ranged between 10 and 518 mg per 100 ml with a mean of 213.2 mg per 100 ml. using the indirect immunofluorescent antibody test, 53.7 per cent of the 111 symptomless subjects in the study had demonstrable malarial antibodies of titres greater than 10,000. the implications of the observations in a holoendemic malarial zone are briefly discussed. | 1978 | 347102 |
| erythrocytic mechanism of sickle cell resistance to malaria. | the physiological basis for the resistance to falciparum malaria individuals with sickle cell trait has not been understood. recent advances in erythrocytic plasmodium falciparum culture have made possible a direct investigation of the development of the malaria parasite in cells with sickle cell homoglobin. in a high (18%) oxygen atmosphere, there is no apparent sickling of cells, and the growth and multiplication of p. falciparum is identical in normal (aa), hemoglobin s homozygous (ss), and h ... | 1978 | 347452 |
| fading of malaria immunity in mice. | fading of immunity in swiss and c3h/stz mice was progressive, and related to both, the interval elapsed since the last challenge infection and survival of parasites. in both mouse strains the proportion of mice that remained immune to challenge decreased with increasing fading periods. moreover, a shift from delayed mortality to a normal course of infection as seen in non-immune controls was observed in c3h/stz mice. early parameters of fading were increasing peak parasitaemias after challenge i ... | 1978 | 347653 |
| [differential diagnostic problems in the recognition of severe infections with plasmodium falciparum]. | | 1977 | 347783 |
| the influence of acetylator phenotype on the response to sulfalene in individuals with chloroquine-resistant falciparum malaria. | the disposition of sulfalene was studied in eight individuals before and during an infection with a chloroquine-resistant strain of plasmodium falciparum. isoniazid acetylator phenotype was determined in each individual prior to the administration of sulfalene. following the administration of sulfalene before infection with malaria, a significant difference in half-life of non-acetylated sulfalene and percent acetylation of sulfalene in plasma was observed between rapid and slow acetylators. whe ... | 1978 | 347958 |
| cerebral malaria. a disseminated vasculomyelinopathy. | neuropathologic examination of 19 fatal cases of cerebral malaria and a review of the literature showed that the epidemiologic, clinical, and pathologic features of this entity suggest consideration of cerebral malaria as a form of disseminated vasculomyelinopathy, a hyperegic reaction of the cns to the antigenic challenge of plasmodium falciparum infection. experimental evidence also substantiates this view the initial event seems to be vasculopathy, with alteration of the endothelial permeabil ... | 1978 | 348169 |
| [hemiparkinsonism, probably due to malaria (author's transl)]. | | 1978 | 348371 |
| [malaria; a summary]. | | 1978 | 348605 |
| pathophysiology of atypical malaria. | | 1977 | 348670 |
| clinical variants of malaria. | | 1977 | 348671 |
| resolution of antimalarial agents via complex formation with alpha-(2,4,5,7-tetranitro-9-fluorenylideneaminooxy) propionic acid. | the resolution of several antimalarial agents via pi-complex formation with alpha-(2,4,5,7-tetranitro-9-fluorenylideneaminooxy) propionic acid (tapa) is reported. since this represents the first use of this agent for the resolution of amines, some details of the separations are presented. the method proved successful for resolving weakly alkaline amines that did not form stable salts with common resolving acids, highly insoluble amines that did not form soluble salts with usual resolving acids, ... | 1978 | 349156 |
| folate antagonists. 10. synthesis and antimalarial effects of 6-[[(aryl and aralkyl)amino]methyl]-2,4-pteridinediamines and -pteridinediamine 8-oxides. | various 6-[[(aryl and aralkyl)amino]methyl]-2,4-pteridinediamines and their 8-oxides have been synthesized for antimalarial evaluation. condensation of 3-amino-6-(bromomethyl)-2-pyrazinecarbonitrile 4-oxide (v) with the appropriately substituted amine afforded a series of 3-amino-6-[[(aryl and aralkyl)amino]methyl]-2-pyrazinecarbonitrile 4-oxides vi. deoxygenation gave the corresponding pyrazines vii. cyclization of vi and vii with guanidine then produced the desired 6-(aminomethyl)-2,4-pteridin ... | 1978 | 349157 |
| folate antagonists. 11. synthesis and antimalarial effects of 6-[(aryloxy- and arylthio-)methyl]-2,4-pteridinediamines and -pteridinediamine 8-oxides. | condensation of 3-amino-6-(bromomethyl)-2-pyrazinecarbonitrile 4-oxide with 4-chlorophenol gave 3-amino-6-[(4-chlorophenoxy)methyl]-2-pyrazinecarbonitrile 4-oxide (1), which was deoxygenated to obtain the de-n-oxide 4. cyclization of 4 and 1 produced 6-[(4-chlorophenoxy)methyl]-2,4-pteridinediamine and the 8-oxide, respectively. 6-[(arylthio)methyl]-2,4-pteridinediamines and their 8-oxides were produced analogously. controlled oxidation of the former gave the anticipated sulfoxide 12 and sulfone ... | 1978 | 349158 |
| falciparum malaria in seamen. | three cases of plasmodium falciparum malaria in seamen, all acquired while working off tropical west africa, and all in patients coming in for treatment at a new orleans hospital during one six-week period, are described in the context of the importance of considering recent travel history for arrival at the correct diagnosis and treatment. two of the three patients whose cases are reported had taken some form of malarial chemoprophylaxis during their voyage. | 1978 | 349186 |
| [acute renal failure and attack of pernicious malaria (apropos of 3 further cases)]. | | 1978 | 349298 |
| falciparum malaria. | | 1978 | 349318 |
| the chemotherapy of rodent malaria, xxix dna relationships within the subgenus plasmodium (vinckeia). | the relationships between rodent malarias were examined by means of dna buoyant density determinations and dna--dna hybridization data. current views of the existence in this group of four species: plasmodium berghei, p. yoelli, p. vinckei and p. chabaudi were confirmed. the identity of two chloroquine-resistant lines derived from p. berghei n strain was established. one of these, the ns line, was found to be a subspecies of p. yoelii; the implications of this finding are discussed. | 1978 | 350169 |
| the chemotherapy of rodent malaria, xxx. the enigmas of the 'ns lines' of p. berghei. | | 1978 | 350170 |
| serum protein fractions in acute falciparum malaria obtained by polyacrylamide gel electrophoresis. | | 1978 | 350171 |
| separation of viable schizont-infected red cells of plasmodium falciparum from human blood. | | 1978 | 350172 |
| relative chloroquine resistance of p falciparum in zambia. | | 1978 | 350347 |
| the effect of proteases on plasmodium formation in didymium iridis. | an improved assay for quantitatively measuring the number of plasmodia formed with time is presented. using this assay we have investigated the effects of three proteases, subtilisin pbn', subtilisin carlsberg and alpha-chymotrypsin. we have shown that 1) plasmodium formation is sensitive to protease treatment only during the first 2 h after mixing amoebae of compatible mating type but not after, 2) amoebae are protease sensitive when treated 1 h prior to mixing, 3) the two clones used have diff ... | 1978 | 350416 |
| plasmodium berghei: biological variation in immune serum-treated mice. | | 1978 | 350601 |
| plasmodium berghei infection in pregnant rats: effects on antibody response and course of infection in offspring. | the effects of primary, patent plasmodium berghei infection in sprague-dawley rats during pregnancy upon the course of infection and the humoral antibody response to malaria in their offspring were examined. malaria specific antibody determined by an indirect fluorescent antibody test correlated well with the parasitologic profiles of each experimental group. utilization of foster mother groups indicated passive transfer of protective antibody through milk. evidence for in utero sensitization by ... | 1978 | 351159 |
| sporozoites of rodent and simian malaria, purified by anion exchangers, retain their immunogenicity and infectivity. | sporozoites of rodent malaria, plasmodium berghei, and simian malaria, plasmodium knowlesi and plasmodium cynomolgi, were partially separated from mosquito debris and microbial contaminants by passage of anopheles material through a deae-cellulose column. in addition to eliminating most of the contaminants (80-90%), this simple technic has made it possible to recover rapidly large numbers of viable sporozoites (55-75% yield), which have retained their infectivity, immunogenicity, and capacity to ... | 1978 | 351177 |
| checklist, host index, and annotated bibliography of plasmodium from reptiles. | world literature on plasmodium of squamate reptiles (1909-1975) includes 156 published accounts on 54 valid species and subspecies. africa: 30 reports on 9 species; australia, asia & oceania: 12 reports on 6 species and 2 subspecies; americas: 116 reports on 37 species. more than half of these reports and new species descriptions appeared during the last 10 years. most concern plasmodia in lizards of the neotropics, georgia (plasmodium floridense, a neotropical-caribbean parasite) and california ... | 1978 | 351178 |
| cultivation of malarial parasites. | the method for continuous cultivation of plasmodium falciparum has now been successfully applied to several strains from different geographical areas. it has been used for tests of antimalarial drugs, for studies of parasite-host cell interactions with special reference to sickle haemoglobin, and for the production of amounts of parasite sufficient for experimental immunisation of aotus trivirgatus monkeys. | 1978 | 351412 |
| autoimmune and polyclonal b cell responses during murine malaria. | | 1978 | 351426 |
| studies on enzyme variation in the murine malaria parasites plasmodium berghei, p. yoelii, p. vinckei and p. chabaudi by starch gel electrophoresis. | electrophoretic variation of the enzymes glucose phosphate isomerase, 6-phosphogluconate dehydrogenase, lactate dehydrogenase and glutamate dehydrogenase (nadp-dependent) has been studied in the african murine malaria parasites plasmodium berghei, p. yoelii, p. vinckei and p. chabaudi and their subspecies. horizontal starch gel electrophoresis was used throughout. the number of isolates examined in each subspecies varied from 1 (p. y. nigeriensis) to 24 (p. c. chabaudi). extensive enzyme variati ... | 1978 | 351525 |
| [western african immigrant's anhaptoglobinemia (author's transl)]. | | 1978 | 351555 |
| [effect of drought on antimalarial immunity]. | | 1978 | 351558 |
| chloroquine resistance produced in vitro in an african strain of human malaria. | after condinous cultivation in the presence of chloroquine, an african strain of the malaria parasite, plasmodium falciparu, acquired resistance to the drug. the resistance was stable and comparable in vitro to that occurring naturally in a strain from southeast asia. this suggests that chloroquine resistance, absent until now in africa, might arise in the future. | 1978 | 351801 |
| the chemotherapy of rodent malaria, xxxi. the effect of some metabolic inhibitors upon chloroquine-induced pigment clumping (cipc) in plasmodium berghei. | the effect of metabolic inhibitors upon chloroquine-induced pigment clumping in intraerythrocytic plasmodium berghei was studied in vitro. oligomycin and venturicidin competitively inhibit the process with 'ki' values of 0.18 and 0.41 mumol/l. dccd, an agent thought to act upon a mitochondrial site close to that affected by oligomycin and venturicidin, causes pigment clumping in the absence of chloroquine ('km' value 4.7 mumol/l). it is suggested that, after being concentrated in the cytoplasm b ... | 1978 | 352284 |
| changes in the hamster liver after experimental infection with schistosoma intercalatum. an ultrastructural study. | syrian hamsters were exposed to cercariae of schistosoma intercalatum. after 70 days, their livers were fixed by vascular perfusion and samples of liver tissue were studied by the electron microscope. lesions consisted predominantly of mature egg granulomas, with some in earlier stages of development. the cells involved in both types of lesion are described together with their relation to the egg and the surrounding liver tissue. only minor abnormalities were seen in the tissue distant from the ... | 1978 | 352285 |
| [indirect immunofluorescence in malaria associated with pregnancy in the senegalese woman]. | | 1978 | 352555 |
| [a probable laboratory contamination with plasmodium falciparum]. | a student working in a medical biology department presented a severe plasmodium falciparum malaria, with high thrombopenia, hypercalcemia and hypophosphoremia. the mode of infection seems to be a laboratory contamination with a highly contaminated blood sample through skin excoriations. | 1977 | 352557 |
| [2 cases of plasmodium falciparum malaria. probable responsibility of anopheles transported by air]. | report of two cases of plasmodium falciparum malaria which seem to be originary from the pariser area: the first one in a luggage carrier working in an airport; the second one in a subject living in the neighbourhood of this airport. these cases perhaps question the hygiene measures taken on the arrival of planes coming from impalutaded regions. | 1977 | 352558 |
| [post-transfusion pernicious plasmodium falciparum attack in a patient with renal insufficiency]. | the authors report one case of transfusion induced falciparum cerebral malaria. among the parasites responsible for transfusion malaria, plasmodium falciparum is rarely implicated, but may be accompanied by serious complications. different ways of artificial transmission of the parasites are reported. clinical findings are few, so the examination of blood films is essential for diagnostic. the dangerous blood donor must be identified by immunofluorescent methods. the specific treatment is quinin ... | 1977 | 352559 |
| polyclonal b-cell activation during rodent malarial infections. | the numbers of 'background' plaque-forming cells (pfc) secreting igm specific for either sheep erythrocytes or horse erythrocytes were found to be elevated in the spleens of balb/c mice during plasmodium berghei and p. yoelii infection. 'background' pfc numbers were similarly elevated in the spleens of uninfected mice injected with high speed supernatants of lysates of parasitized red blood cells. the active factor (or factors) in the supernatants was (were) non-dialysable and stable at 56 degre ... | 1978 | 352584 |
| prospects for immunisation against malaria. | | 1978 | 352630 |
| role of the surface coat in in vitro attachment and phagocytosis of plasmodium berghei by peritoneal macrophages. | evidence is presented to indicate that plasmodium berghei merozoites, but not trophozotites, have an antiphagocytic capsule. the capsule appears to form around the developing merozoties of the schizont in the parasitophorous vacuole. serum from animals immune to p. berghei reacts with this capsule. after reaction with immune serum, the antiphagocytic action of the capsule is lost. by the process of binding serum protein, the capsule becomes electron dense and can be readily visuallzed as the sur ... | 1978 | 352960 |
| a new class of antimalarial drugs: derivatives of benzothiopyrans. | a series of substituted benzothiopyrans was synthesized and examined for antimalarial activity. some were found to be active and curative at dose levels of 160--360 mg/kg against plasmodium berghei in mice. afew observations concerning structure-activity relationships were made. the benzothiopyrans were prepared by treatment of either the gem-dichloro- or the thionothioflavone intermediate with various primary amines. the thionothioflavone intermediates were made from thioflavones. condensation ... | 1978 | 353282 |
| [comparison of mosquito infectiosity with the causative agents of malaria from blood sucking on man and through a biomembrane]. | | 1978 | 353474 |
| cellular mechanism for the protective effect of haemoglobin s against p. falciparum malaria. | | 1978 | 353566 |