| [influence of schizophyllan, streptomycin and rifampicin on histopathological changes in mice infected with tubercle bacilli (author's transl)]. | experimental tuberculosis in mice infected with streptomycin-resistant mycobacterium tuberculosis schacht strain was treated with streptomycin or rifampicin alone and in combination with schizophyllan. the histopathogical tests of various organs of the treated mice were carried out. 1) in the group of mice treated with streptomycin alone, the moderate focal proliferation of re cells were seen at the beginning of infection. however, durable activation of re cells and the prolongation of life-span ... | 1975 | 125808 |
| simple amidase test for identification of mycobacteria. | a modified amidase test for differentiation of mycobacteria is described. a total of 224 atypical mycobacteria, 154 mycobacterium tuberculosis, and 26 m. bovis strains were classified by this procedure. of the 404 strains of various species studied, 400 exhibited an amidase spectrum identical to the established pattern. the simplicity of this method may promote its application in routine examinations. | 1975 | 126248 |
| immunological adjuvants. vii. kinetic study on the adjuvant effect of wax d. | | 1975 | 126534 |
| chemical structure of the cell wall of mycobacterium tuberculosis var. bovis, strain bcg. | bcg cell walls contain approximately 30% free lipids like other mycobacterial cell walls. the insoluble skeleton of the cell wall is made up of two covalently linked polymers, a peptidoglycan and an arabinogalactan mycolate, with which are associated non peptidoglycan amino acids and a glucan. we present data on two structural features: 1. the "non peptidoglycan" amino acids; they form two kinds of compounds: peptide chains which can be solubilized by proteolytic enzymes and a trypsin-chymotryps ... | 1975 | 126548 |
| cell-mediated immune reactions in vitro to cell walls and peptidoglycan from staphylococcus aureus. | migration inhibition factor (mif) was produced by peritoneal exudate (pe) cells from guinea pigs sensitized with heat-killed cells of staphylococcus aureus cultured in vitro with staphylococcal cell walls or defined subunits of the cell walls. mif activity was assayed by inhibition of migration of alveolar macrophages from lungs of normal guinea pigs. specificity of inhibition was established using pe cells from tuberculin sensitive guinea pigs and tuberculin as appropriate controls. staphylococ ... | 1975 | 126563 |
| the kidney in infectious diseases. | | 1976 | 129758 |
| [cultivation bt negativity in microscopically positive sputum samples (author's transl)]. | | 1975 | 130982 |
| [laboratory diagnosis of tuberculosis (author's transl)]. | | 1975 | 131272 |
| [apparatus for perparations of wire tampons (author's transl)]. | | 1976 | 132290 |
| stimulation of the phagocytic activity of the reticuloendothelial system in adjuvant arthritis in the rat. | the administration of mycobacterial adjuvant produced a stimulation of the reticuloendothelial system (res) phagocytic function. the degree of such a stimulation was greater in lewis than in avn inbred strain of rats. there was no relationship between the degree of res stimulation and clinical signs of adjuvant-induced arthritis. | 1976 | 134533 |
| development of two inbred strains of rats and characteristics of their skin reactions. | two inbred strains of rat (donryu and sprague-dawley strains) were developed. the skin reactions of these strains immunized with m. tuberculosis, hen egg albumin (ova) or hen egg lysozyme and challenged with the purified protein derivative (ppd) or each antigen were even and uniform. the donryu strain showed a typical arthus reaction with petechiae and edema and a negligible delayed skin reaction, whereas the sprague-dawley strain showed a poor arthus reaction and a typical delayed skin reaction ... | 1976 | 140679 |
| [epidemiological characteristization tuberculosis foci]. | | 1977 | 147461 |
| [a contribution to problems of possible use of tissue cultures in diagnostics of pulmonary tuberculosis (author's transl)]. | | 1977 | 147746 |
| [mycobacterium fortuitum infection after total hip prosthesis. a report of 3 cases (author's transl)]. | the authors have observed three instances of sepsis due to mycobacterium fortuitum complicating total hip replacement for osteoarthritis. the case histories are fully described. the requirements are given for recognition of the organism which grows on special culture media and which may be mistaken for mycobacterium tuberculosis. this feature explains why, in some cases, the organism may not be discovered. antibiotics were ineffective but the general condition of the patient was not greatly affe ... | 1979 | 155857 |
| [mycobacterium fortuitum infection after total hip prosthesis. a report of 3 cases (author's transl)]. | the authors have observed three instances of sepsis due to mycobacterium fortuitum complicating total hip replacement for osteoarthritis. the case histories are fully described. the requirements are given for recognition of the organism which grows on special culture media and which may be mistaken for mycobacterium tuberculosis. this feature explains why, in some cases, the organism may not be discovered. antibiotics were ineffective but the general condition of the patient was not greatly affe ... | 1979 | 156387 |
| [peritoneal tuberculosis in africa (author's transl)]. | peritonel tuberculosis is quite frequent overseas and specially in africa; as an example, it is about 0,5 p. 100 of the admittances and 13 p. 100 of the total number of tuberculous cases recorded in dakar and djibouti, over a period of four years. first symptoms are not caracteristic but rapidly one may observe either ascitic or non-ascitic forms, with eventually pseudo-tumoral or adhesive aspect. diagnostic criteria are reviewed as well as the therapeutic rules and results. | 1979 | 158695 |
| persistent papillomatosis associated with immunodeficiency. | a case report of a young bull with persistent papillomatosis associated with immunodeficiency is presented. humoral immune responses were normal but cell mediated immunity was deficient. the possible significance of the findings to pathogenesis and therapy of the disease is discussed. | 1975 | 165037 |
| specific immunity and nonspecific resistance to infection: listeria, protozoa, and viruses in mice and hamsters,. | specific immunity developed by mice against protozoan (toxoplasma gondii and besnoitia jellisoni) and bacterial (listeria monocytogenes) infections was compared with nonspecific protection conferred by prior infections. the results indicated that homologous immunity protected mice from more than 10-5 ld50 of t. gondii or b. jellisoni, but from only 10-2 ld50 of l. monocytogenes. heterospecific protection among these organisms was for 10-0.4 minus 10-1.2 ld50. in studies in hamsters specific immu ... | 1975 | 165241 |
| [results of 79 hepatic biopsies in untreated bacillary pleurs pulmonary tuberculosis patients]. | the authors report 79 needle biopsies of the liver, using a menghini needle, carried out as routine in untreated cases of pulmonary tuberculosis with positive sputum. apart from the histological study, the authors carried out, in 30 cases, a bacteriological study of the liver fragment. the bacteriological and histological results are reported here in detail, then compared with those in the world literature. no significant correlation was found between the histological type of the suggestive hepa ... | 1975 | 166442 |
| effect of mycobacterium bovis and mycobacterium tuberculosis on the take and survival of chickens with transplanted mc-29 hepatoma. | | 1975 | 166869 |
| immune and non-immune macrophage resistance to the fibroma-myxoma virus complex. | | 1975 | 168379 |
| pathways of carbohydrate metabolism in mycobacterium tuberculosis h37rv1. | radiorespirometric studies using glucose labelled at 1, 2, 3-4, and 6 positions and enzymatic studies were conducted to determine the primary pathways of glucose dissimilation in mycobacterium tuberculosis h37rv. the pattern of 14co2 recovery was c3-4 greater than c1 greater than c6 = c2. the embden-meyerhof pathway was found to be the predominant pathway for glucose oxidation, operative to the extent of 94%. the pentose phosphate pathway accounted for the remaining 6%. maximum incorporation of ... | 1975 | 172204 |
| [bacterio-epidemiological significance of diabetes mellitus-pulmonary tuberculosis syntropy]. | the author discusses infectivity before and after complex treatment with the classical tuberculostatics in 42 diabetics with chronic pulmonary tuberculosis of the total of 78 subjects followed up for three years, the other 36 subjects being compensated metabolically and pulmonarily. although the number of negative cases increased fourfold there remained a high proportion of bacilli eliminators, the diabetics becoming negative at a much slower rate. | 1975 | 174180 |
| [basic studies on viomycin and tuberactinomycin (author's transl)]. | | 1975 | 175205 |
| analysis of metabolic changes in revertants of antibiotic-resistant micobacteria. | in the present report evaluation of the possible metabolic changes in partially revertants of m. tuberculosis var. hominis, reisolated from strains at high levels of drug-resistance after treatment with mutagenic agents, was reported. based on the data presented here, it must be concluded that no significant biological and biochemical differences in mycobacterial cells revertant from high mutants mono-resistant to four aminoglycosides (sm, kana, vio, neo) and p-aminonasalicylic acid (pas) are to ... | 1975 | 177028 |
| isolation and characterization of serologically active phosphatidylinositol oligomannosides of mycobacterium tuberculosis. | phospholipids extracted with hot methanol from mycobacterium tuberculosis, strain h37rv, were fractionated with solvent mixtures and by partition chromatography on silica-gel columns. of 12 components detected on a thin-layer chromatogram of the total phospholipid fraction, 6 components were purified. they were all phosphatidylinositol oligomannosides: two hexamannosides (h-2 and h-3), one tetramannoside (h-4), one trimannoside (h-5), and two dimannosides (h-6 and h-7). the molar ratios of fatty ... | 1975 | 178641 |
| [dynamics of the appearance and persistence of elimination of mycobacteria and their significance (report)]. | | 1976 | 181831 |
| adjuvant disease induced by mycobacteria, determinants of arthritogenicity. | genetic, endocrine and immunological factors are probably involved in adjuvant polyarthritis. the nature of the vehicle and of the mycobacterial components administered also has a major influence. it was originally assumed that arthritogenicity and adjuvanticity of mycobacterial fractions such as wax d were intimately related. our previous findings showed that the water soluble adjuvant (wsa) of m.smegmatis which could substitute for mycobacterial cells in freund's complete adjuvant and induce d ... | 1976 | 181972 |
| mode of action of isoniazide (inh). short communication: isolation and identification of an analog of nad from 3h-inh-treated bacterial cells. | | 1976 | 182179 |
| in vitro studies on the mechanism of acquired resistance to tuberculous infection. ii. the effects of the culture supernatants of specifically stimulated-sensitized lymphocytes on the growth of tubercle bacilli within macrophages. | immune lymph node cells were obtained from mice immunized with bovine gamma globulin (bgg) in complete freund's adjuvant or allogeneic mh134 tumor cells. they showed the capacity of conferring bactericidal activity on macrophages infected with mycobacterium tuberculosis, h37rv, when they were incubated on macrophage monolayers together with the corresponding antigen, i.e., bgg or solubilized cellular antigen of the tumor cells. however, such capacity was lower than that of tubercle bacilli-immun ... | 1976 | 186655 |
| direct and cooperative mechanisms of lymphocyte triggering in liquid and solid cultures. | the role of cell interactions in lymphocyte stimulation was analyzed by studying the kinetics of lymphocyte proliferation at different cell concentrations, and also by a lymphocyte microculture technique in solid medium. an absolute requirement for cell interactions was found in lymphocyte responses to concanavalin a, pokeweed mitogen, sodium periodate, purified protein derivative from mycobacterium tuberculosis, and zinc chloride. no requirement for cell interactions was found in lymphocyte res ... | 1977 | 190313 |
| adenosine 3', 5'-monophosphate in mycobacteria. | | 1977 | 191715 |
| [frequency of isolation of tuberculous bacilli as a function of some mechanical factors in patients with pulmonary tuberculosis]. | a series of mechanical factors, such as postural changes and every day movements, favour mobilization of bronchoalveolar secretions and, hence, offer greater chanses of detecting the tuberculosis bacillus. it is recommended to collect, in out-patient units, two sputum samples, one in the morning and the second several hours later, after beginning the day's work. | 1977 | 191890 |
| the relationship between nicotinamide adenine dinucleotide concentration and antibacterial activity of isoniazid in mycobacterium tuberculosis. | the relationship between the antibacterial effect of isoniazid and the intracellular concentration of nicotinamide adenine dinucleotide (nad) was investigated in mycobacterium tuberculosis strain h37rv given continuous and pulsed exposures to the drug. depletion of nad to a plateau value occurred rapidly during exposure, and recovery after a pulse of isoniazid was also rapid. it seemed unlikely that nad depletion was the direct cause of the antibacterial activity because (1) insufficient depleti ... | 1977 | 192114 |
| [tuberculosis of migrant black africans]. | a study of 357 cases of tuberculosis in african negro immigrants seen between 1967 and 1971 showed the predominance of respiratory lesions especially pulmonary and/or hilar ganglio-mediastinal lesions compared with lesions elsewhere, e.g. lymph nodes, bones, joints, pericardium, peritoneum, livers, and the frequency of multiple lesions. routine detection should be more frequent in high risk subjects, who are almost always allergic on arrival in france. in spite of frequent resistance, above all ... | 1977 | 194330 |
| [non-culturable koch bacilli during antitubercular chemotherapy]. | the authors have performed 58435 microscopic examinations, of which 3813 were positive, and found 209 (5,48%) cases of non-cultivable koch bacilli. the major bacteriological, clinico-evolutive and therapeutical aspects are examined. most of the cases showing a syndrome of positive homogenate with a negative culture were rather recent ones (an evolution of less than 2 years in 73,68% of the total) and the highest frequency was found in those in which the treatment was in its first year. no direct ... | 1977 | 195329 |
| adenosine 3',5'-monophosphate in mycobacterium phlei and mycobacterium tuberculosis h37ra. | adenosine 3',5'-monophosphate (camp) is present in slow growing as well as fast growing mycobacteria. apparently there does not seem to be any direct relationship between either intra- or extracellular camp content with the growth rate of bacilli. as compared to that of e. coli grown on a similar energy source, camp content is much higher in mycobacteria. camp content inside the cells remains unaltered throughout the growth period and this may be due to lack of complete utilization of the major ... | 1976 | 196160 |
| specificity of isoniazid on growth inhibition and competition for an oxidized nicotinamide adenine dinucleotide regulatory site on the electron transport pathway in mycobacterium phlei. | the mechanism of action of isoniazid (inh) on saprophytic and atypical mycobacteria is thought to be different from that on mycobacterium tuberculosis because higher concentrations are required to be effective in these species. in this investigation, m. phlei was inhibited by inh at a concentration of 25 mug/ml. benzoic acid hydrazide (bzh) and nicotinic acid hydrazide (nah) were inhibitory at levels of 300 and 500 mug/ml, respectively. inhibition by these compounds was not inoculum dependent. a ... | 1977 | 197885 |
| [disinfection of soil of the pasture land]. | | 1977 | 198942 |
| [clinical, radiological and bacteriological study of pulmonary tuberculosis with bacteria showing drug resistance]. | the authors have investigated two groups of patients of young age suffering from tuberculosis with germs showing primary resistance to chemotherapeutic agents (61 cases), and with germs displaying sensitivity to these agents (64 cases). the following conclusions have been reached: tuberculosis with germs showing primary drug resistance did not display onset modalities, clinically and radiologically, that differed significantly from other types of tuberculosis; sputum conversion is more slow in p ... | 1977 | 201007 |
| enhanced resistance against encephalomyocarditis virus infection in mice, induced by a nonviable mycobacterium tuberculosis oil-droplet vaccine. | female c57b1/10 mice injected intravenously (i.v.) with nonviable mycobacterium tuberculosis jamaica cells associated with oil-droplet emulsions (wcv) were highly resistant to the i.v. injection of encephalomyocarditis virus (emcv). resistance to infection (87% survival) was detected from 1 week to at least 12 weeks after injection of wcv. mice vaccinated i.v. also were resistant to intraperitoneal, subcutaneous, or intramuscular virus challenge, but were not resistant to intracranial challenge. ... | 1978 | 203533 |
| [antimicrobially effective pyridazines]. | | 1977 | 203953 |
| [intermittent chemotherapy from the beginning or only after a period of daily administration? quantitative bacteriological study at the initial phase of chemotherapy with inh + rmp + emb in daily or intermittent administration]. | a number of 75 adults with pulmonary tuberculosis (m. tuberculosis positive at microscopy and in cultures) were randomly selected for one of the following therapeutical regimens, administered under close surveillance in hospital during 3 months: --inh5 mg/kg body weight+rmp10 mg/kg body weight+emb25 mg/kg body weight daily; --inh15 mg/kg body weight+rmp10 mg/kg body weight+emb40 mg/kg body weight, intermitent administration (2/7). disappearance of the mycobacterium from the sputum was studied qu ... | 1977 | 204971 |
| angiotensin-converting enzyme in macrophages and freund's adjuvant granuloma. | low angiotensin-converting enzyme (ace) activity was found in rat and mouse peritoneal macrophages, in rat and rabbit pulmonary alveolar macrophages, in cultured mouse peritoneal macrophages stimulated i.p. for four days by thioglycollate, and in rabbit pulmonary alveolar macrophages stimulated in culture by 0.1 to 100 microgram/ml salmonella typhosa endotoxin for four days. rat subcutaneous freund's adjuvant granulomas induced with mycobacterium butyricum or m. tuberculosis h37 ra contianed low ... | 1978 | 205523 |
| [considerations on the meta-herpetic keratitis (author's transl)]. | the meta-herpetic keratitis is clinically characterized by the occurrence of a parenchymatous keratitis due to iterative herpetic corneal wounds. the rupture of the bowman membrane which makes such a deep wound possible is performed by an enzyme: collagenase. this parenchymatous keratitis is rarely due to an extension of the viral infection. most often it has an immunologic origin. it is a disciform keratitis due to a viral allergy, or a polymorphic keratitis connected with a bacterial, often tu ... | 1978 | 206762 |
| [the effectiveness of some culture media with pyruvic acid bases for the isolation of mycobacteria from sputum]. | the authors have studied the value of culture media based on pyruvic acid (the dixon medium and an original medium called p.t.) in the isolation of mycobacteria from sputum, as compared with the löwenstein-jensen medium. the studies were carried out in two groups of patients: 1043 samples were collected from ambulatory patients and 1740 samples were collected from hospitalized patients. the superiority of the dixon and of the p.t. media was confirmed by the increased percentage of positive cultu ... | 1978 | 206944 |
| effect of mycobacterium tuberculosis bcg infection on the resistance of mice to ectromelia virus infection: participation of interferon in enhanced resistance. | mice infected with mycobacterium tuberculosis bcg were more resistant than normal mice to ectromelia virus infection. it is suggested that enhanced interferon production in peritoneal exudate cells and spleen cells of bcg-infected mice plays an important role in this resistance. | 1978 | 208973 |
| [causes of failure in neutralization, recovery and social rehabilitation of chronic eliminators of koch bacilli treated with rifampin and ethambutol]. | | 1978 | 212812 |
| [clinical studies of the role of the fluorescent circulating antibody test in the diagnosis of active tuberculosis]. | the value was studied, of the test of circulating fluorescent antibodies against m. tuberculosis in establishing the diagnosis of active tuberculosis in 610 patients classified in 4 groups: 1. active tuberculosis bacteriologically confirmed; 2. active tuberculosis with negative bacteriological examination, but confirmed by other methods of criteria; 3. stabilized tuberculosis; 4. non-tuberculous affections. the specificity of the test in active tuberculosis was of 80% in adults and of 91,5% in c ... | 1978 | 212813 |
| induction of enhanced resistance against encephalomyocarditis virus infection of mice by nonviable mycobacterium tuberculosis: mechanisms of protection. | nonviable mycobacterium tuberculosis strain jamaica suspended in oil-droplet emulsions was used to enhance resistance of mice against encephalomyocarditis virus (emcv). the mycobacteria-injected mice were significantly resistant to 50,000 50% lethal doses of emcv. similar concentrations of virus in plasma of normal and mycobacteria-injected mice from 1 to 120 min after injection of emcv showed that resistance was not a result of rapid elimination of virus from the circulation. furthermore, survi ... | 1978 | 215550 |
| [risk factors and high-risk groups in the prevention of tuberculosis]. | starting from the premise that in the methodology of tuberculosis control priority should be given to the higher risk groups, the authors tried to identify such groups and list them in the order of their priority within the district of a dispensary serving a population of about 400,000 inhabitants. on comparing the results of the detection of risk factors among the population in general with that per endangered groups it was found that the former presented a decrease (from 1.09 to 0.44 per thous ... | 1978 | 217059 |
| [current incidence and clinical significance of non-culturable bacilli or those culturable with difficulty]. | an analysis of 246 patients with positive smear present bacilli and negative cultures revealed that in only 9% of the cases no organized previous treatment had been applied, although almost half of these had benefited from short courses with streptomycin associated with penicillin before an exact diagnosis of tuberculosis had been made. since the remaining 91% had had 1--2 months of chemotherapy, which frequently included rifampicin, the authors stress that microscopically detectable germs are f ... | 1978 | 217063 |
| cerebrospinal fluid lymphocyte transformations in meningitis. | cerebrospinal fluid lymphocytes from 13 patients with nonsuppurative meningitis were cultured with antigens derived from mycobacterium tuberculosis, sporotrichum schenckii, and herpes simplex. when csf lymphocytes from five patients with infections associated with these organisms were incubated with "correct" antigen there was increased incorporation of thymidine. the levels were higher than those seen when the cells were incubated with different antigens or when csf lymphocytes from patients wi ... | 1979 | 219789 |
| [studies of the action of lipari pumice dust on experimental tuberculosis in guinea pigs and on cultures of koch bacillus]. | | 1978 | 222225 |
| generation of cytotoxic lymphocytes against human tumor cells in vitro by various soluble microbial extracts. | | 1979 | 222929 |
| [results of intermittent biweekly treatment with rifampicin and ethambutol in silicotuberculosis]. | the results were analysed, of the results obtained by the associated treatment with rifampicin and etambutol 2/7 for at least 6 months in 53 patients with silico-tuberculosis and positive bacteriologic tests. only two of the patients in the group were in the 1-st stage of silicosis while half of the patients had cavities. also 50% of the patients had strains showing resistance to various drugs. only five of the patients did not receive chemotherapy before the start of the study. immediate favour ... | 1979 | 223222 |
| [evaluation of initial supervised and integrated treatment of tuberculosis]. | the operational and technical efficiencies were evaluated, of the initial, intermittently administered chemotherapy, supervised and integrated by the general medical network. the treatment was applied in 160 patients detected in 53 rural medical districts. it was noted that under the operational aspect the treatment was applied in 100% of the eligible patients, and administration of all the necessary doses was achieved in 91,6% of the patients. bacteriological negativation by the direct examinat ... | 1979 | 227036 |
| [analysis of failures of chemotherapy of pulmonary tuberculosis in adults]. | | 1979 | 229540 |
| [observations on the number of sputum samples used in establishing the bacteriological diagnosis of pulmonary tuberculosis]. | | 1979 | 229542 |
| comparison of the in vivo & in vitro activities of adenylate cyclase from mycobacterium tuberculosis h37ra (nctc 7417). | | 1979 | 231572 |
| [effectiveness of treatment with rifampicin and isoniazid in association with ethambutol or prothionamide in patients with recently detected pulmonary tuberculosis]. | in newly discovered patients with cavitary forms of pulmonary tuberculosis treatment with rifampicin, in association with other drugs, leads to recovery (negativation) in 69,6 percent of the patients in 3 months, in 92 per cent after 6 months and in 94,6 percent after 9 months of treatment. closure of cavities is found in 23,4 percent, 64,5 percent and 76,6 percent of all patients at the corresponding time intervals. comparisons of the various regimens of chemotherapy which include rifampicin sh ... | 1979 | 232302 |
| adenosine triphosphatase of mycobacteria. | a mg+2-(ca+2)-activated adenosine triphosphatase activity has been demonstrated in saprophytic, human pathogenic and non-pathogenic, and atypical, species of mycobacteria. (na+ + k+)-activated adenosine triphosphatase was absent in the species investigated. the effect of age of culture on enzyme activity was revealed in an increase up to mid logarithmic phase of growth, and a decline thereafter. differences in oxygen tensin during growth did not alter enzyme activity. isonicotinic acid hydrazide ... | 1979 | 233112 |
| variations in the pathways of malate oxidation and phosphorylation in different species of mycobacteria. | mycobacterium tuberculosis h37rv, the slow-growing human pathogenic strain of tubercle bacilli and mycobacterium smegmatis and mycobacterium phlei, the fast-growing saprophytes, have shown variations regarding the type of dehydrogenase that initiates malate oxidation in the respiratory chain. m. tuberculosis h37rv is characterized by having a malate oxidase system (designated malnad pathway) in which malate oxidation is mediated by the nad+-dependent malate dehydrogenase (ec 1.1.1.37) but not by ... | 1975 | 234747 |
| detection of antibodies to mycobacterium tuberculosis by solid phase radioimmunoassay. | the sandwich solid phase radioimmunoassay procedure has been adapted to the serological diagnosis of tuberculosis by the use of disposable plastic haemagglutination trays in which the wells were sensitized with soluble mycobacterial antigen and the subsequent uptake of globulin from test sera detected with radioiodinated antiglobulin. the influence of time and temperature of the incubation stages, ph, washing times, drying and the efficiency of various non-specific blocking agents have been stud ... | 1975 | 234990 |
| 1-alkyl-2-nitroimidazol-5-yl derivatives. i. | | 1975 | 235267 |
| natural antibodies in healthy adults. | the serum of 100 adults living in budapest was examined for isohaemagglutinin titre with haemaglutination, for staphylococcal-antitoxin titre with haemolysis inhibition and for bacterial antibody titre against 17 different groups of bacteria with passive haemagglutination. antibody levels in males, except for certain bacterial antibodies, were somewhat lower than in females. the antibody titres, especially in men, decreased gradually from 20 to 50 years of age and were usually lower in rh negati ... | 1975 | 235827 |
| the relationship between length of incubation, bacterial growth and tuberculin yield of a strain of mycobacterium tuberculosis. | the relationship was studied between length of incubation in a liquid synthetic medium, amount of bacterial growth, ph of the culture filtrate and tuberculin yield of a single strain, dt, of mycobacterium tuberculosis. no sinple relationship was found between the total crop of bacteria and the tuberculoprotein content of the culture filtrate. on the other hand, protein release and the ph of the culture filtrate were closely related. in each of two trials the bacterial crop increased rapidly duri ... | 1975 | 238317 |
| 1-alkyl-2-nitroimidazol-5-yl derivatives ii. n-substituted nitrones. | | 1975 | 239726 |
| growth inhibition of mycobacterium tuberculosis by oleate in acidified medium. | | 1975 | 240119 |
| abnormal forms of bacteria produced by antibiotics. | subinhibitory concentrations of antibiotics can produce in vitro aberrant forms of bacteria that are similar to those observed in specimens and cultures from patients being treated with antibacterial agents. eight species of bacteria were grown on membranes placed on agar containing subinhibitory concentrations of nine antibiotics. the resulting organisms were examined by gram stain and electron microscopy. gram stains showed filamentous and granular forms of enterobacteria with bipolar staining ... | 1975 | 242211 |
| the purification and properties of peroxidase in mycobacterium tuberculosis h37rv and its possible role in the mechanism of action of isonicotinic acid hydrazide. | peroxidase from mycobacterium tuberculosis h37rv was purified to homogeneity. the homogeneous protein exhibits catalase and y (youatt's)-enzyme activities in addition to peroxidase activity. further confirmation that the three activities are due to a single enzyme was accomplished by other criteria, such as differential thermal inactivation, sensitivity to different inhibitors, and co-purification. the y enzyme (peroxidase) was separated from nadase (nad+ glycohydrolase) inhibitor by gel filtrat ... | 1975 | 242321 |
| multiple skin testing of tuberculosis patients with a range of new tuberculins, and a comparison with leprosy and mycobacterium ulcerans infection. | four hundred and seventy tuberculosis patients were each skin tested with four of a range of 17 mycobacterial reagents in four countries in all of which tuberculosis and leprosy were endemic. sixteen of the reagents were new tuberculins prepared from extracts of living mycobacteria disrupted by ultrasonic disintegration and the last was ppd, rt23.the effect that tuberculosis exerted on the delayed-type skin test response to these antigens was assessed by comparing results for tuberculosis patien ... | 1977 | 266538 |
| tuberculosis due to mycobacterium kansasii. | eighteen cases of tuberculosis due to mycobacterium kansasii have been described. eleven were from western australia and seven from queensland. the symptoms, x-rays and histology of the disease were indistinguishable from those due to mycobacterium tuberculosis, but the organisms were resistant to streptomycin, para-amino-salicylic (pas) and isoniazid, but sensitive to ethionamide and cycloserine, and in most cases sensitive to rifampicin and ethambutol. all 18 cases were treated with some form ... | 1977 | 266899 |
| the production of a lymphocyte inhibitory factor (lyif) by bursal and thymic lymphocytes. | in this study the migration and migration inhibition of different lymphoid cell populations from immunized and control birds were evaluated. bursal, thymic, and splenic cells migrated in a capillary tube with thymic cells forming the characteristic cone of cells within 4 hours of culture. both thymic and bursal cell populations from birds sensitized by mycobacterium tuberculosis produced a lymphocyte inhibitory factor (lyif) when stimulated by specific antigen in vitro. the ability of bursal cel ... | 1977 | 303455 |
| many bacterial species are mitogenic for human blood b lymphocytes. | thirty bacterial species were tested for their ability to stimulate to increased dna synthesis in human blood lymphocytes. a definite stimulation was obtained with eighteen bacterial species. for three of these species ten different strains of each were tested, and all increased dna synthesis. the maximum response was after 3--4 days of culture, suggesting a mitogenic effect. this was confirmed by the induction of polyclonal antibody production shown by a plague assay, which was positive for nin ... | 1978 | 309629 |
| [further study of the problem of specific cellular receptors in delayed hypersensitivity]. | the work presents the materials obtained as a result of the further study of specific t lymphocyte receptors with the use of so-called receptor antisera, i. e. antisera against the lymphoid cells of mice sensitized with one of the two antigens (macobacterium tuberculosis or bovine gamma globulin); thus these differed from control antisera against the lymphoid cells of intact mice. these mouse antisera reacted with the lymphoid cells of guinea pigs in experiments of delayed-type hypersensitivity ... | 1979 | 315679 |
| cytochemical and biological properties of mycobacterium bovis bcg. | it was the aim of the present communication to find a simple test for a reliable discrimination of mycobacterium bovis bcg from mycobacterium tuberculosis. a total of 26 bcg strains, out of them 10 czechoslovak strains (2 lyophilized cultures of bcg of different batch, 6 strains isolated from abscesses of children after bcg-vaccination and 2 strains from fatal cases after bcg-vaccination) and 16 strains obtained from foreign laboratories, were used. of the tested characteristics a combination of ... | 1977 | 330364 |
| suppression of cell-mediated immune responses by dextran sulphate. | the effect of high molecular weight dextran sulphate (ds) on cell-mediated immune responses was studied. two criteria were used to assess cell-mediated responses, skin graft rejection and intra-dermal (i.d.) skin tests. mice receiving allografts and ds displayed a significant increase in graft survival time compared with untreated control animals. similar results were obtained when the grafted animals differed at only the h-y locus. guinea-pigs sensitized with mycobacterium tuberculosis and trea ... | 1977 | 338479 |
| immunization of mice after airborne infection with various strains of bcg. | the growth of 6 strains of bacillus calmette-guérin (bcg) in the lungs of mice was compared after direct implantation into those organs. bacilli of the connaught, pasteur, phipps, and tice strains multiplied appreciably in the lungs and disseminated into the spleen in contrast, bcg birkhaug and glaxo strains did not replicate in the lungs or spread to the spleen. the immunizing ability of 3 of these strains was examined in more detail. aerosol infection with bcg glaxo, pasteur, or phipps strains ... | 1978 | 339795 |
| induction of interferon by stimulation with tuberculin in mice previously infected with mycobacterium tuberculosis strain bcg. | | 1977 | 357822 |
| a comparison of cross protection between bcg, hammondia hammondi, besnoitia jellisoni and toxoplasma gondii in hamsters. | the effect of pretreatment with bcg strain of mycobacterium tuberculosis or hammondia hammondi 21 days before challenge with lethal doses of t oxoplasma gondii and besnoitia jellisoni was studied in hamsters. the results indicated that the intracardial administration of bcg provided no protection against either t. gondii or b. jellisoni. the hamsters immunized with h. hammondi survived challenge with 10(4) lethal doses of t. gondii but only 1 lethal dose with b. jellisoni, indicating strong cros ... | 1978 | 364045 |
| [comparison of mycobacterium tuberculosis frequency detection on media according to sula, löwenstein-jensen, ogawa, and stonebrink, after pretreatment of the pathogenic material with lauryl sulphate of sodium (author's transl)]. | | 1979 | 376065 |
| identification of tubercle bacilli. | initial screening of tubercle bacilli with 2-thiophene carboxylic acid hydrazide (tch) or 2-furoic acid hydrazide (fah) separates them into two groups. resistant strains are mycobacterium tuberculosis. sensitive strains include m. tuberculosis, m. bovis and bcg which are separated by nitratase and oxygen requirement tests. pyrazinamide sensitivity tests allow m. bovis and m. africanum to be identified. the niacin test is not used. most strains of m. tuberculosis from europeans are resistant to t ... | 1979 | 389130 |
| tuberculous infection in a vascular prosthesis: a case of aortic graft infection resulting from disseminated tuberculosis. | insertion of an aortic prosthetic bypass graft in a patient with untreated disseminated tuberculosis resulted in graft infection with formation of a pseudoaneurysm. microbiologic cultures implicated mycobacterium tuberculosis as the causative agent, and a subsequent review of the literature indicated this report to be the first clinical demonstration of the susceptibility of vascular prosthesis to m tuberculosis infection to our knowledge. | 1977 | 401636 |
| [forming of "o" group of dispensary registration and methods of determining activity of tuberculous changes in the lungs]. | | 1977 | 402001 |
| [evolution and outcome of the tuberculous process produced by various mycobacterium tuberculosis in rabbits]. | | 1977 | 402002 |
| persistence of mycobacterium tuberculosis in sputum without chest roentgenographic evidence of active disease. | mycobacterium tuberculosis has been isolated consistently from sputum over an 11-year period in an asymptomatic 64-year-old man whose chest radiographs show evidence of healed primary tuberculosis (ranke complex) but no evidence of parenchymal disease. a lymph node-bronchial fistula associated with the ranke complex is the likely site of active tuberculosis; however, repeated examinations of the upper and lower respiratory tract have been normal. we attribute the persistence of infection in our ... | 1977 | 402095 |
| rate of ribonucleic acid chain growth in mycobacterium tuberculosis h37rv. | two methods were employed to measure the rate of ribonucleic acid (rna) chain growth in vivo in mycobacterium tuberculosis h37rv cultures growing in sauton medium at 37 degrees c, with a generation time of 10 h. in the first, the bacteria were allowed to assimilate [3h]uracil or [3h]guanine into their rna for short time periods. the rna was then extracted and hydrolyzed with alkali, and the radioactivity in the resulting nucleotides and nucleosides was measured. the data obtained by this method ... | 1977 | 402354 |
| mycotic tuberculous aneurysm of the thoracic aorta. | tuberculous mycotic aneurysm has been reported with surprising frequency, especially in the aorta. because the diagnosis can often be made on clinical and roentgenologic grounds, and because of the very poor prognosis if untreated and surgical curability if recognized, experience with three cases is reported. the aneurysm is generally of the false variety, representing a walled-off perforation of the aorta. contiguous tuberculosis in the form of lymphadenitis or pott abscess is generally respons ... | 1977 | 402488 |
| [experimental study on the effect of the immune lymphocytes on the growth of tubercle bacilli in macrophages (author's transl)]. | | 1977 | 402495 |
| [mycobacteriocin typing of human type tubercle bacilli (author's transl)]. | | 1977 | 402496 |
| [cross-resistance of tubercle bacilli (a review). (i) (author's transl)]. | | 1977 | 402497 |
| primary drug-resistant tuberculosis in massachusetts, 1975-1976. | | 1977 | 402580 |
| mycobacterium tuberculosis resistance to rifampicin and ethambutol: a clinical survey. | ninety-seven cultures of myco, tuberculosis referred to the tuberculosis reference laboratory, cardiff during 1972-73 and found to be resistant to rifampicin or ethambutol were studied. resistance to each drug appeared equally common. few lower grades of rifampicin resistance occurred, cultures tending to be either fully sensitive or highly resistant. intermediate grades of ethambutol resistance, however, were common, and a majority of highly resistant cultures were preceded by cultures showing ... | 1977 | 402706 |
| [secondary drug resistance of mycobacterium tuberculosis in chronic destructive forms of pulmonary tuberculosis]. | | 1977 | 402746 |
| stability of bacteriophage type of mycobacterium tuberculosis: absence of variation caused by experimental chemotherapy in mice and analysis of spontaneous variation. | the bacteriophage typing of 54 strains isolated from the tissues of mice infected with the strain h37rv of mycobacterium tuberculosis and treated with isonazid and rifampin showed that the bacteriophage type did not change. the fluctuation analysis of populations of the tubercle bacilli demonstrated that the rate of mutation from sensitivity to resistance in respect to the bacteriophage ds6a was less than 1.3 x 10(-8) mutations per bacterium per generation. | 1977 | 402876 |
| [incidence of tuberculotic conditions in patients from non-tuberculotic health institutions (microbiologic study covering the years 1964-1974) (author's transl)]. | | 1977 | 402985 |
| suppressor cell influence in selected strains of inbred rats. i. strain-dependent mitogen- and antigen-related low responsiveness. | | 1977 | 403016 |
| a rapid radiometric method for determining the sensitivity of clinical isolates of mycobacterium tuberculosis to several chemotherapeutic agents. | current methods of performing antibiotic susceptibility tests on m. tuberculosis require 4 to 6 weeks for completion and in some cases have a poor correlation with clinical results. we have developed a rapid radiometric method of sensitivity testing which utilizes the incorporation of 3h-uracil into ribonucleic acid (rna) as a measure of mycobacterial growth. the radiometric method is sensitive and reproducible and the results are completed in 48 hours. an excellent correlation was found between ... | 1977 | 403245 |
| [standard therapy, schematic and individual treatment of tuberculosis - controlled clinical trials and determination of antimycobacterial activities in the serum (author's transl)]. | | 1977 | 403517 |