| ontogeny of b lymphocyte function. vi. ontogeny of thymus cell capacity to facilitate the functional maturation of b lymphocytes. | the differentiation of the b cell population from fetal mice to produce a normal, adult-like, heterogeneous reponse, with respect to antibody affinity, has been shown to require (or to be facilitated by) thymus cells. the maturation of the thymus cell population to be capable of facilitating this differentiation of the b cell population was studied. it was found that the thymus cell population acquires the capacity fo facilitate (or induce) this maturation of the b cell population between seven ... | 1978 | 357163 |
| effect of anticancer therapy of lymphocyte cytotoxicity in lung cancer patients. | cytotoxicity of lymphocytes against allogeneic target cells of a bronchogenic squamous cell carcinoma was examined by a microcytotoxicity test in lung cancer patients after the various kinds of anticancer treatment. cytotoxicity in untreated cases at stages i, ii, and iii was higher than the range of controls, but cytotoxicity in those at stage iv decreased to the range of controls. tumor resection augmented cytotoxicity in patients at stages ii and iii, when the assays were carried out 3 weeks ... | 1977 | 357239 |
| induction of interferon by stimulation with tuberculin in mice previously infected with mycobacterium tuberculosis strain bcg. | | 1977 | 357822 |
| genetic control of granuloma response to oil-associated bcg cell wall vaccine in mice. | intravenous injection of mice with bcg cell wall vaccine induces granuloma in the lung. the granuloma induced as measured by lung weight showed marked strain differences; c3h/hems bred in this institute (c3h), c3heb/fej, p/j and a/he were low responders, whereas c57bl/6 and akr/he were high responders. when c57bl/6 and c3h were compared, the responsiveness appeared to be inherent in each strain of mice providing strong evidence for genetic control in this phenomenon. breeding experiments suggest ... | 1978 | 357935 |
| antitumor activity of hot-water extract from delipidated bcg. | the antitumor activity of hot-water extract of delipidated bcg was investigated in mice inoculated with sarcoma-180 cells and ehrlich carcinoma cells, respectively. the hot-water extract was found to be effective when administered after and ineffective when administered before the inoculation of tumor cells. when this extract was given with anticancer drugs, such as mitomycin c and cyclophosphamide, a combined effect was obtained in the treatment of sarcoma-180 and of ehrlich carcinoma. | 1978 | 358496 |
| [delayed local reaction (dlr) after bcg vaccination in mice. i.--description (author's transl]. | mice injected subcutaneously in the hind footpad with bcg vaccine subsequently develop a local reaction. this local reaction could be divided into three stages: a first characterized as an acute inflammatory reaction, a second as an active granulome formation, and a third as a chronic long lasting inflammatory reaction. the second stage is mainly formed by the appearance of a typical histiolymphocytic granuloma. the intensity of the delayed local reaction (dlr) is measured by the swelling of the ... | 1978 | 358908 |
| population density as a factor in the evolution of neoplastic cell lines. | the influence of population density in the progression from the nonneoplastic to the neoplastic state has been reassessed. two twice-cloned, nonneoplastic mouse lines, nctc 7914 and 7915, were transferred each 3 to 4 days at inoculum sizes selected to minimize or maximize cell-cell contact, 1 x 10(5) or 4 x 10(5) cells/t-15, respectively. as tested by in vivo assay, the regime designed to minimize cell-cell contact did not reproducibly delay transformation, and tumor production was observed in a ... | 1978 | 359129 |
| modification of the migration of mouse lymphoid cells by bcg: a factor stimulating t-cell migration. | | 1978 | 359172 |
| refractoriness to migration inhibitory factor of macrophages of lps nonresponder mouse strains. | the responsiveness to macrophage migration inhibitory factor (mif) of peritoneal exudate cells (pec) from the lps unresponsive c3h/hej and c57bl/10sccr mice was assessed by the indirect agarose microdroplet macrophage migration inhibition assay. no migration inhibition with pec from c3h/hej nor c57bl/10sccr mice was detected, whereas pec from both c3h/hen and c57bl/10sn mice were significantly inhibited by even a 1/32 dilution of mif-containing supernatants. responsiveness to mif of c3h/hej pec ... | 1978 | 359704 |
| effect of bcg vaccination on the igg and complement receptors on rabbit alveolar macrophages. | | 1978 | 359804 |
| [microbiological studies of tissue specimens from tuberculin-positive cattle slaughtered for diagnostic purposes in the opole province]. | | 1978 | 360181 |
| [immunological properties of cellular membranes of mycobacterium bovis]. | | 1978 | 360207 |
| bovine pulmonary tuberculosis in adults. a new view of an old infection. | | 1978 | 360623 |
| immunotherapy of a guinea pig hepatoma with mycobacterial vaccines: comparison of bcg cell walls and cell wall skeletons. | bcg cell wall skeletons (sk) derived from bcg cell walls (cw) by treatment with proteolytic enzymes and organic solvents were tested for their potency to cause regression of a transplanted guinea pig hepatoma. on a weight basic, sk were as effective as cw in causing tumor regression, and they, as well as purified protein derivative of mycobacteria, provoked delayed cutaneous hypersensitivity reactions in animals immunized with cw or with sk. on a weight basis, cw were more active than sk in elic ... | 1978 | 361572 |
| opposite effects of bcg on spleen and lymph node cells: lymphocyte proliferation and immunoglobulin synthesis. | c57bl/6 mice were immunized intravenously (i.v.), intraperitoneally (i.p.), or subcutaneously with one dose of bacillus calmette-guérin (bcg). at various time intervals after injection, the lymphocyte response, as measured by thymidine incorporation into dna, and the number of immunoglobulin-secreting cells were determined in vitro before and after mitogenic stimulation with phytohemagglutinin, concanavalin a, or lipopolysaccharide. in unstimulated cultures, the spontaneous thymidine incorporati ... | 1978 | 361574 |
| delayed-type hypersensitivity to rabies virus in mice: assay of active or passive sensitization by the footpad test. | with a purified beta-propiolactone-inactivated rabies virus, a significant increase in footpad swelling was elicited in normal or in bcg-pretreated mice after immunization with varying doses of rabies vaccine. these footpad reactions were shown to peak at 24 h and to be associated with an infiltration of newly formed blood monocytes demonstrated by histology and [125i]deoxyuridine labeling. a relationship between the lymphoproliferation and the degree of sensitization is described, and the susce ... | 1978 | 361580 |
| the effect of intramural injection of immunotherapeutic agents on bladder histology and systemic humoral response. | bacillus calmette-guerín (bcg), corynebacterium parvum, and various mycobacterium fragments were injected intramurally into mouse bladders and the resulting systemic humoral stimulation and local histologic reactions were evaluated. c. parvum and methanol extracted residue of bcg elicited significant immunostimulation without producing irreversible bladder damage. the severe histologic disruption caused by bcg could be reduced by the antituberculus drug isoniazed without abrogating the humoral s ... | 1978 | 361626 |
| natural cytotoxic cells against solid tumors in mice. ii. some characteristics of the effector cells. | | 1978 | 361891 |
| mode of immunopotentiating action of bcg: persistence and spread of bcg infection. | the mode of action of bcg, strain japan was investigated using the immune response to sheep red blood cells (srbc) as an indicator system. when srbc were injected into the bcg-primed foot pad, the direct plaque forming cells (pfc) and the effector cells responsible for delayed type hypersensitivity (pth) were produced in various lymphoid organs widely distributed. furthermore, bacterial counts in the draining popliteal lymph node and the spleen in the mice inoculated with bcg into the hind foot ... | 1978 | 362025 |
| experimental pseudomonas infection in mice: acquired resistance against pseudomonas septicemia and altered susceptibility in bcg infected mice. | pseudomonas septicemia in mice caused the early death in the first three days of infection without any localized lesions. localized lesions such as abscess are observed in the kidney and liver after the third day of infection. the early death increased in the bcg infected mice showing an increased level of macrophage activation. it seemed that such early death is due to endotoxin produced by pseudomonas aeruginosa. however, the bcg infected mice showing an enhanced antibody formation were more r ... | 1978 | 362026 |
| endotoxin induced metabolic alterations in bcg infected (hyperreactive) mice. | | 1978 | 362424 |
| immunotherapy for cancer. | it seems nonetheless reasonable to take a skeptical view of immunotherapy for cancer. if the immunologic response can be brought to bear meaningfully and effectively upon the tumorhost relationship so that the host is spared, then let it be proved by appropriate clinical trials. without unrealistic expectations, it may be easier to tolerance the gradual realization that immunotherapy may be only peripherally important in the control of malignant disease. | 1978 | 362576 |
| natural killer cells. in vitro and in vivo. | a nonadherent, nonphagocytic mouse cell found in lymphoid organelles, but lacking characteristic surface markers of mature lymphocytes, is capable of lysing a wide spectrum of tumor cells but shows little cytolytic activity toward normal cells. this cytotoxic cell, termed a "natural killer" (nk) cell, shows a marked capacity to lyse lymphomas (syngeneic, allogeneic, or even xenogeneic) to the effector cell source. its activity is inhibited by a variety of pharmacologic agents, eg, cytochalasins, ... | 1978 | 362942 |
| macrophage fusion factor elicited from bgg-sensitized lymphocytes. | lymphocytes obtained from rabbit lymph nodes sensitized to bovine gamma globulin produce in vitro the lymphokine macrophage fusion factor (mff) which mediates the fusion of approximately 100% of normal alveolar and oil-induced peritoneal macrophages. giant cells (gc) of langhans and foreign body type form large syncytia containing as many as several hundred nuclei per cell. nuclei of gc appear more spherical and larger than those of the normal mononucleated macrophages, and they possess several ... | 1978 | 362945 |
| schistosoma mansoni infection in intact and b cell deficient mice: the effect of pretreatment with bcg in these experimental models. | the course of infection with schistosoma mansoni was determined in b cell deficient mice by means of a schistosomule lung recovery assay 6 days after infection or by determination of the adult worm burden 7 weeks after infection. the intensity of infection was not significantly different from that in age- and sex-matched intact controls. b cell deficiency was demonstrated by absence of surface immunoglobulin-bearing cells in the spleen and by absence of b cell areas in the lymphoid follicles of ... | 1978 | 362959 |
| immunologic studies in holstein-friesian cattle: an immunocompetence profile. | an immunocompetence profile has been developed for holstein-friesian cattle. in vitro and in vivo immunoassays were used to determine (1) the percentage of peripheral blood lymphocyte (pbl) subpopulations bearing surface-membrane receptors for sheep erythrocytes, complement, or surface immunoglobulin; (2) the pbl blastogenic response to leukoagglutinin, concanavalin a, or pokeweed mitogen, (3) the serum immunoglobulin concentrations of igg, igm, and iga, (4) the humoral antibody response to keyh ... | 1978 | 362996 |
| macrophage activation for tumor cytotoxicity: tumoricidal activity by macrophages from c3h/hej mice requires at least two activation stimuli. | | 1978 | 363288 |
| production of reference ppd tuberculins for veterinary use in the united states. | | 1978 | 363720 |
| effect of immunization of cats with isospora felis and bcg on immunity to reexcretion of toxoplasma gondii oocysts. | the effect of pretreatment with isospora felis and bacillus calmette-guérin (bcg) on the reexcretion of toxoplasma gondii oocysts was studied in 16 coccidia-free cats. the following conclusions were drawn: (a) chronically t. gondii-infected cats reexcreted t. gondii oocysts after superinfection with i. felis, and this reexcretion was prevented in cats infected with i. felis before t. gondii infection. (b) administration of bcg before toxoplasma infection had no apparent effect on the outcome of ... | 1978 | 364044 |
| a comparison of cross protection between bcg, hammondia hammondi, besnoitia jellisoni and toxoplasma gondii in hamsters. | the effect of pretreatment with bcg strain of mycobacterium tuberculosis or hammondia hammondi 21 days before challenge with lethal doses of t oxoplasma gondii and besnoitia jellisoni was studied in hamsters. the results indicated that the intracardial administration of bcg provided no protection against either t. gondii or b. jellisoni. the hamsters immunized with h. hammondi survived challenge with 10(4) lethal doses of t. gondii but only 1 lethal dose with b. jellisoni, indicating strong cros ... | 1978 | 364045 |
| [the role of immunocompetent cells in the murine pulmonary granulomatous response induced by bcg (author's transl)]. | | 1978 | 364130 |
| stimulation of tumor growth in mice by high doses of bcg. | the growth of krebs-2 carcinoma in bcg-prevaccinated virgin female c57bl/6, cc57br/m, and c3hf mice was studied in relation to the number of living mycobacteria in the organism. when the number of mycobacteria was high, tumor growth was stimulated. after the bacteria were eliminated, tumor growth was inhibited. the effect of bcg was based, on the one hand, on the diversion of effector cells, presumably macrophages, responsible for tumor defense and, on the other hand, on the activation of the po ... | 1978 | 364150 |
| [atypical mycobacteria]. | | 1978 | 364277 |
| effect of isoniazid on bcg-mediated tumor immunity. | | 1977 | 364713 |
| prospects for the development of dead vaccines against helminths. | | 1978 | 364956 |
| heat stability of mycobacterium leprae immunogenicity. | the protection provided to mice by vaccines administered intradermally was measured after footpad challenge with mycobacterium leprae. the protection offered by m. leprae suspensions was not decreased when the vaccines were killed by 60 degrees c heat or at the higher temperatures tested, which included 215 degrees c (autoclave). even highly purified suspensions retained their immunogenicity. in contrast, the vaccine protection provided by intradermal m. bovis (strain bcg) was markedly reduced w ... | 1978 | 365752 |
| hyporeactivity factor produced after induction of immune interferon in mice sensitized with bcg. | sera from bcg-sensitized icr and c57bl/10j mice challenged with bcg were examined. two types of hyporeactive factor (hf), which produced refractoriness to induction of interferon (if) by newcastle disease virus in mouse embryo fibroblasts, were produced in addition to type ii immune if. one was destroyed at ph 2, and the other was not. the acid-labile hf, together with immune if, appeared 2 h after challenge with bcg. acid-labile hf and immune if were not neutralized by antiserum against l-cell ... | 1978 | 365756 |
| strain difference of delayed-type hypersensitivity to bcg and its genetic control in mice. | delayed-type hypersensitivity to bcg was remarkably different in two inbred strains of mice, swm/ms and c3h/he, when measured by the spleen index, the disappearance of peritoneal macrophage, or the footpad reaction. high responsiveness in the swm/ms strain appeared to be dominant over low responsiveness in the c3h/he strain. results of the footpad reaction test if f1, f2, and backcross hybrids of these two strains of mice suggested that the delayed-type hypersensitivity was mainly controlled by ... | 1978 | 365763 |
| a recovered case of generalized bcg infection. | a female infant was at the age of 8 months admitted with muco-cutaneous candidiasis. the applied therapy was inefficacious. subsequent examinations pointed to a combined humoral and cellular immunopathy. at the age of 7 years the patient was readmitted with abdominal complaints. diagnostic laparotomy revealed a tuberculous mesenterial growth. the isolated agent proved to be a bcg strain. antituberculous therapy was beneficial, the tumour dissappeared and full recovery was attained. the mycotic p ... | 1978 | 367051 |
| [delayed type hypersensitivity reactions to "candida albicans" in mice (author's transl)]. | mice injected intravenously (iv) or subcutaneously (sc) with living candida albicans developed subsequently delayed-type hypersensitivity (dth) which was measured in vivo by the footpad test after injection of 10(6) heat killed c. albicans (hkc.a.). compared to systemic injections, sc immunizations with living c.a. gave higher levels of dth, and lethality was absent. subcutaneous injections of hundred time more doses of hkc.a. were also able to produce in normal mice a dth reaction elicited with ... | 1978 | 367260 |
| mechanisms of metastasis. | | 1979 | 367443 |
| lymphocyte response of leprosy patients to human-derived and purified armadillo-derived mycobacterium leprae, bcg and ppd. | the lymphocyte transformation test was applied to compare in vitro lymphocyte responses of tuberculoid (high resistant) and lepromatous (low resistant) leprosy patients to purified mycobacterium leprae derived from experimentally infected armadillos and crude m. leprae derived from man, as well as to bacille calmette-guérin (bcg) and purified protein derivative (ppd). it was found that the purification procedure using enzymic digestion did not affect the immunogenicity of armadillo-derived m. le ... | 1978 | 367652 |
| [current status of immunotherapy of malignant tumors]. | | 1979 | 367730 |
| [chemotherapy of malignant melanomas]. | | 1978 | 367896 |
| [monocytopoiesis and macrophage accumulation in inflammatory and malignant diseases]. | | 1978 | 367902 |
| extracellular cytolysis by activated macrophages and granulocytes. i. pharmacologic triggering of effector cells and the release of hydrogen peroxide. | lymphoma cells were rapidly lysed by activated macrophages and granulocytes in the presence of pma. release of 51cr from lymphoma cells correlated closely with their destruction as viewed by scanning electron microscopy, and with reduction in the number of trypan blue-excluding cells. the standard assay involved 51 cr release measured at 4.5 h, but injury appeared to be complete in 1 h. of eight different types of effector cells tested, only those releasing abundant h2o2 in response to pma were ... | 1979 | 368287 |
| [epidemiological importance of bovine tuberculosis for rural inhabitants]. | | 1979 | 368762 |
| adjuvants in the induction of suppressor cells. | the effect of different mycobacterial adjuvants on the parameters of delayed hypersensitivity was investigated in strain 13 guinea pigs. the composition of the tubercle bacilli and the type of vehicle in which the antigen was presented determined the presence and extent of suppressor cell activity. when antigen was introduced in complete freund adjuvant, both adherent and nonadherent cells had suppressive properties, with the suppressive effect demonstrable in vitro from 1 to 5 weeks after sensi ... | 1979 | 370015 |
| [a case of generalized infection with low virulent tubercle bacilli indistinguishable from bcg, showing proliferation of histiocytes with numerous bacilli but without epithelioid granuloma (author's transl)]. | | 1978 | 370432 |
| antibody response in rabbits to mycobacterium bovis bcg. | the specificity of the immune response after immunization with mycobacterium bovis bcg was studied by crossed immunoelectrophoresis with intermediate gel in a bcg/anti-bcg system, in which the reaction against thirty distinct components of bcg was recorded. after a single injection of total sonicate of 3 mg (dry weight) bacilli, the antibody response was markedly similar in eight rabbits. th earliest and strongest response was directed against nine components of bcg; all but one of these belonge ... | 1979 | 370972 |
| synergistic activity of components of mycobacteria and mutant salmonella in causing regression of line-10 tumors in guinea pigs. | | 1979 | 371795 |
| phytohemagglutinin (pha) skin test. characterization of immunological properties and clinical application. | immunological properties of phytohemagglutinin (pha) skin reaction were investigated by animal and clinical experiments. in the guinea pigs an intradermal dose of pha-p produced erythema and induration with a maximal response at 24 hours after the injection. histologically it was characterized by perivascular infiltration of lymphoid cells in the dermis and subcutis, being similar to that of tuberculin (ppd) skin reaction. pha skin reaction, however, showed some difference from that of ppd in th ... | 1979 | 371848 |
| the variable response of bacteria to excess ferric iron in host tissues. | the enhancement by exogenous ferric iron, both systemic and local, of the infectivity of 120 strains of bacteria, representing 17 genera, was measured in the skin of guinea-pigs. systemic iron enhanced only 23% of 115 strains, and local iron 49% of 71 strains. systemic iron, by an apparently anti-inflammatory action, depressed the size of lesions produced by 27 of the non-enhanced strains from nine of the genera tested. for most strains, the degree of enhancement was small, ranging from 2- to 8- ... | 1979 | 372534 |
| systemic antitumor activity of bacillus calmette guerin and purified protein derivatives against tumors in mice having tuberculin allergy. | | 1978 | 372638 |
| stimulation of rna synthesis in l-929 cells by rabbit tumor necrosis factor. | | 1979 | 372951 |
| lymphocyte unresponsiveness to ppd tuberculin in badgers infected with mycobacterium bovis. | lymphocyte transformation tests using phytohaemagglutinin and concanavalin a showed that both t and b lymphocytes are functional in tuberculous badgers. dose response curves indicated that purified protein derivative sensitised lymphocytes were suppressed when cultured in the presence of the antigen. | 1978 | 373034 |
| [bcg sepsis as a fatal complication of bcg vaccination]. | fatal septicemia with bacillus calmette-guérin (bcg) following bcg vaccination is always caused by an underlying defect of immunologic mechanisms. at the children's hospital, university of berne, two cases of bcg septicemia were recently observed. the clinical picture, course, and pathogenesis of the illness are discussed. the harmless complications of bcg vaccination are summarized, and a review of the literature on fatal disseminated bcg infection stresses the different type of immunologic mec ... | 1979 | 373107 |
| a pilot study to assess the usefulness of elisa in detecting tuberculosis in badgers. | | 1979 | 373225 |
| regulation of the immune response to tumor antigen. | reduction of syngeneic tumor growth in primary tumor-bearing murine hosts has been accomplished using a variety of treatments designed to decrease endogenous suppressor cell activity or augment host effector responses. selective interference with suppressor cell function can be achieved by in vivo administration of anti-thymocyte serums at critical times during the early stages of tumor development or by continuous treatment with antiserums directed to interact with i-j determinants on suppresso ... | 1979 | 373460 |
| chronic inflammation involving cellular hypersensitivity. | | 1979 | 374015 |
| antitumor activity of peritoneal exudate cells induced by cell-wall skeleton of mycobacterium bovis bcg. | peritoneal exudate cells (pec) induced by oil-attached cell-wall skeleton of mycobacterium bovis bcg (bcg-cws) in aci/n rats were tested for their effect on both in vivo and in vitro growth of syngeneic fibrosarcoma cells (amc-60). treatment of rats with intraperitoneal injections of bcg-cws induced regression of syngeneic ascites tumor and increased the number of survivals. whole pec and adherent pec from rats injected intraperitoneally with bcg-cws inhibited the uptake of tritiated thymidine i ... | 1978 | 374173 |
| adjuvant chemo-immuno-therapy with lmf+bcg in node-negeative and node-positive breast cancer. | | 1978 | 374199 |
| peritoneal exudate t lymphocytes with specificity to sheep red blood cells. i. production and characterization as to function and phenotype. | t lymphocytes which mediate dth reactions to sheep red blood cells (srbc) in mice enter casein-induced peritoneal exudates from which they can be recovered and assayed in a passive transfer system. peritoneal exudates need not contain specific antigen for inducement of t-cell immigration. the amount (or biological activity) of dth-transferring peritoneal exudate lymphocytes is enhanced by the previous use of immune modulating agents, such as cyclophosphamide (cy) (200 mg/kg 2 days prior to sensi ... | 1979 | 374258 |
| in vitro production and cellular origin of murine type ii interferon. | antigen-specific type ii interferon was produced in vitro by harvesting supernatants of spleen cell cultures from swiss-webster mice sensitized with mycobacterium bovis strain bcg and challenged with old tuberculin. treatment of c3h mouse spleen cell cultures with appropriate anti-ia, anti-igg, anti-thy-1 or anti-ly-2,3 sera resulted in a significant decrease in production of type ii interferon. removal of nylon wool adherent cells or cells with histamine receptors by column chromatography simil ... | 1979 | 374263 |
| simultaneous generation of tuberculin-type and cutaneous basophilic hypersensitivity at separate sites in the guinea pig. | | 1979 | 374281 |
| a new method for quantitation of cell-mediated immunity in the mouse. | | 1979 | 374732 |
| progressive and fatal infection with attenuated mycobacterium bovis (bcg) in nude mice. | congenitally athymic nude mice (nu/nu) were infected intravenously with mycobacterium bovis bcg japanese strain under specified pathogen-free (spf) or germ-free (gf) conditions. spf euthymic litter mates (nu/+) serving as controls were found to tolerate the infection well, while spf nu/nu mice following infection of 3 x 10(7) organisms died by week-36. animals having received a very small dose (3 x 10(0) of organisms and their non-infected cage mates showed no evidence of infection at week 37 po ... | 1978 | 374803 |
| five cultivable mycobacterial strains giving blast transformation and leukocyte migration inhibition of leukocytes analogous to mycobacterium leprae. | | 1978 | 374869 |
| phagocytic and antimicrobial activities of rabbit peritoneal and alveolar macrophages activated with mycobacterium bovis bcg on candida albicans. | | 1978 | 375350 |
| immunotherapy of solid tumor. | | 1979 | 375448 |
| the influence of daunomycin on development of yoshida sarcoma after nonspecific stimulation of the immunologic system. | injection of bcg in rats inoculated with yoshida sarcoma had no influence on the development of the tumor or survival time of the rats in comparison with the control group. on the other hand, survival time was increased more than threefold in a group of rats injected with daunomycin in a single dose of 1 mg/kg i.p. longest survival and lowest mortality were observed in a group of rats treated with daunomycin and bcg, in which survival time was six times longer than in the controls, and mortality ... | 1979 | 375868 |
| regression of established oral tumors after intralesional injection of living bcg or bcg cell walls. | oral tumors with associated cervical lymph node metastases developed after injection of tumor cells into buccal pads of inbred guinea pigs. intralesional injection of living bcg or bcg cell walls (cw) caused regression of established tumors, prevented the development of cervical lymph node metastases and led to the development of host resistance to the growth of subsequent tumor transplant. | 1979 | 376088 |
| effect of ok-432 on immunization with mitomycin-c-treated l1210 cells. | the pretreatment of b6d2f1 mice with ok-432 alone was not so effective to retard the growth of l1210 leukemia, and the leukemic cell was poorly immunogenic in the mice. however, when ok-432 was given by ip injection in combination with mitomycin-c-treated l1210 cells, the growth of l1210 leukemia was significantly retarded and some mice did not "take" the leukemia. meanwhile, bcg was also effective in this respect. differences in properties as an immunopotentiator between ok-432 and bcg were sug ... | 1979 | 376388 |
| immunoadjuvant treatment of primary grafted and spontaneous akr-leukemia. i. treatment efficiency correlated to autoimmune reactivity. | young akr mice grafted i.v. with 10(1) or 10(3) cells from spontaneous akr thymomas were treated with repeated i.v. injections of bcg or subcutaneous injections of irradiated akr thymoma cells. bcg often cured mice from graft leukemia, whereas the effect of irradiated thymoma cells was less effective. mice that did not develop graft-leukemia after graft of 10(1) leukemia cells and bcg treatment showed a spontaneous leukemia in 30% of the cases later. ninety percent of nongrafted mice developed s ... | 1979 | 376705 |
| immunoadjuvant treatment of primary grafted and spontaneous akr-leukemia. ii. in vitro cytotoxicity of lymphoid cells against normal and malignant syngeneic cells and against normal allogeneic cells. | | 1979 | 376706 |
| defective tumoricidal capacity of macrophages from a/j mice. i. characterization of the macrophage cytotoxic defect after in vivo and in vitro activation stimuli. | macrophages from a/j mice fail to develop tumoricidal activity after any of several in vivo or in vitro treatments that activate cells from c3h/hen mice. peritoneal macrophages from a/j mice treated i.p. with viable mycobacterium bovis, strain bcg, killed corynebacterium parvum, or pyran copolymer fail to develop in vitro tumoricidal activity; varying the numbers of macrophages from treated mice added to target cells, or the dose and time of treatment, or the treatment schedule of these in vivo ... | 1979 | 376720 |
| defective tumoricidal capacity of macrophages from a/j mice. ii. comparison of the macrophage cytotoxic defect of a/j mice with that of lipid a-unresponsive c3h/hej mice. | | 1979 | 376721 |
| in vitro killing of schistosomula of schistosoma mansoni by bcg and c. parvum-activated macrophages. | resistance to schistosoma mansoni infection in the mouse has been induced either specifically by a primary infection with this parasite or nonspecifically by a variety of immunostimulants such as bcg. in the present study we developed an in vitro system to examine the effector mechanism of nonspecifically induced resistance. activated macrophage monolayers obtained from bcg- or corynebacterium parvum treated mice killed a respective mean 32 +/- 6% and 48 +/- 5% of schistosomula after 24 hr incub ... | 1979 | 376723 |
| bacillus calmette-guerin immunotherapy of the cancer-contaminated wound. | | 1979 | 376948 |
| effect of m.bovis bcg and m.microti on sarcoma 180 growth in mice. | the antitumorous efficacy of the czechoslovak bcg 725, czechoslovak bcg 901, the danish sas maintained, the japanese sas and sh maintained bcg strain and the czechoslovak ov 247 (m.microti) strain was studied. (sas--original sauton's medium with asparagine, sh--sauton's medium with the asparagine replaced by enzymatic casein hydrolysate.) ascitic sa 180 cells were used as the experimental tumor and 800 mice as experimental animals. all the strains employed displayed an anticarcinogenic effect in ... | 1978 | 377109 |
| current state of clinical immunotherapy. | | 1979 | 377611 |
| [mycobacteria isolated from environmental objects]. | | 1979 | 377787 |
| bovine tuberculosis in the united states and puerto rico: a laboratory summary. | mycobacteria were isolated from 14.3% of the tissues submitted to the national veterinary services laboratories over a 5-year period (july 1, 1972, to june 30, 1977). the isolates were identified by drug susceptibility, and biochemical and serologic tests. mycobacterium bovis isolated from tissues of cattle originating in 32 states and puerto rico accounted for 78% of the acid-fast isolations. of the mycobacterium bovis isolates, 4% were from tissues in which no microscopic tuberculous granuloma ... | 1979 | 378044 |
| suppression of specific lymphocyte blastogenesis after intravenous tuberculin injection in mycobacterium bovis-sensitized cattle. | intravenous injection of 1.0 ml of old tuberculin (ot) in 4 calves previously sensitized to mycobacterium bovis resulted in suppression of specific lymphocyte blastogenic responses to purified protein in vitro. suppression of in vitro blastogenic responses occurred within 24 hours after injection of ot and persisted for up to 96 hours. lymphocytes from these calves, cultured with concanavalin a, did not show any suppression of the lymphocyte blastogenic response in vitro. suppression was tempora ... | 1979 | 378045 |
| macrophage activation for tumor cytotoxicity: genetic variation in macrophage tumoricidal capacity among mouse strains. | | 1979 | 378423 |
| protection of cotton rats against experimental echinococcus multilocularis infections with bcg cell walls. | previous works has indicated that cotton rats treated with mycobacterium bovis strain bcg are effectively protected against an infection with the metastatically proliferating metacestodes of echinococcus multilocularis. in an attempt to induce a similar protection in the absence of tubercular granulomatous lesions, cotton rats were treated with bcg cell walls. a single injection of 150 micrograms of cell walls, emulsified in mineral oil-tween-saline, 2 weeks before the inoculation of the parasit ... | 1979 | 378829 |
| induction of cell-mediated immunity to mycobacterium leprae in guinea pigs. | guinea pigs immunized with intact or disrupted armadillo-grown human mycobacterium leprae administered in aqueous or oil vehicles were tested with various dilutions of m. leprae suspended in saline, water-soluble m. leprae extract, purified protein derivative, and a water-soluble extract of normal armadillo tissue. the results demonstrated the following. (i) under no conditions was any skin test reactivity found to normal armadillo tissue extract. (ii) positive sensitization to both m. leprae an ... | 1979 | 378838 |
| effects of bcg infection on the susceptibility of mouse macrophages to endotoxin. | mice infected intravenously with mycobacterium bovis (bcg) are 100 to 1,000 times more sensitive to the lethal effects of bacterial lipopolysaccharides (lps). since bcg infection results in macrophage activation and lps may cause pathophysiological effects through interaction with this cell type, it was of interest to determine whether macrophages from bcg-infected animals were more susceptible to the toxic effects of lps in vitro. when lps-susceptible, c57bl/6 mice were infected with bcg, a sig ... | 1979 | 378847 |
| delayed-type hypersensitivity responses in mice infected with st. louis encephalitis virus: kinetics of the response and effects of immunoregulatory agents. | labeled monocyte infiltration techniques have been used to study delayed-type hypersensitivity responses in mice immunized with st. louis encephalitis virus. a delayed 24- to 48-h inflammatory response occurred 6 to 7 days after immunization. this response can be potentiated by cyclophosphamide treatment, by bcg administration, or by splenectomy. treatments known to selectivity inhibit t-cell function suppressed the response. | 1979 | 378848 |
| immunotherapy of guinea pigs with dermal and visceral tumor implants: comparison of living and nonliving bcg. | emulsified cell walls of mycobacterium bovis (bcg) were immunotherapeutically at least as active as living bcg in prolonging survival of guinea pigs with established dermal tumors and microscopic lymph node and visceral metastases. | 1979 | 378859 |
| influence of oil and tween concentrations on enhanced endotoxin lethality in mice pretreated with emulsified trehalose-6,6'-dimycolate (cord factor). | susceptibility to the lethal toxicity of endotoxin in mice pretreated with emulsified trehalose-6,6'-dimycolate was enhanced by (i) increasing the oil concentration while keeping the tween concentration constant; and (ii) decreasing the tween concentration, while keeping the oil concentration constant. | 1979 | 378860 |
| lymphocyte transformation test in healthy contacts of patients with leprosy. i. influence of exposure to leprosy within a household. | fifty-three household contacts of lepromatous patients, 37 household contacts of tuberculoid patients, and 91 control persons were examined with the lymphocyte transformation test (ltt) for their responses to whole and sonicated antigen preparations from m. leprae, to bcg, m. avium, m. gordonae, and phytohemagglutinin (pha). the study was carried out in the gurage area of ethiopia in 15 households with a leprosy patient and 15 matched control households. household contacts of lepromatous patient ... | 1979 | 378871 |
| lymphocyte transformation test in healthy contacts of patients with leprosy. ii. influence of consanguinity with the patient, sex, and age. | the study was carried out in the gurage area of ethiopia, where 53 household contacts of lepromatous patients, 37 household contacts of tuberculoid patients, and 91 control persons were examined with the lymphocyte transformation test (ltt) for their responses to whole and sonicated antigen preparation from m. leprae to bcg, m. avium, m. gordonae and phytohemagglutinin. the potential influence of host factors, namely the state of consanguinity with the leprosy patient, sex and age on the ltt res ... | 1979 | 378872 |
| the chemistry and biology of a hot water extract from delipidated mycobacterium bovis, strain bcg. | | 1978 | 379996 |
| the dilemma regarding postoperative chemotherapy in primary carcinoma of the colon. | | 1979 | 380029 |
| monitoring of macrophage activation by immunoadjuvants in mice as judged by functional criteria. | | 1978 | 380599 |
| variation among mouse strains in responsiveness to migration inhibitory factor. | | 1979 | 380823 |
| potency and suppurative adenitis in bcg vaccination. | studies performed up to now in animal and man show that potent bcg strains guarantee a higher protection against tuberculosis than strains with weak virulence. vaccine prepared from a strong bcg strain may be administered in lower doses, reducing the incidence of suppurative adenitis to a level acceptable by the individual patients and the health authorities. | 1978 | 381076 |
| comparative study on antitumor effect of cell-wall skeleton of mycobacterium bovis bcg and nocardia rubra, with reference to t-cell dependency and independency. | antitumor activity induced by the oil-attached cell-wall skeleton of nocardia rubra (n-cws) was compared with that of the oil-attached cell-wall skeleton of mycobacterium bovis bcg (bcg-cws) in syngeneic balb/c tumor-host systems. in normal balb/c mice (+/+), n-cws exhibited stronger suppressive effect on syngeneic br-1 and mca tumors than did bcg-cws. in athymic nude mice (nu/nu), bcg-cws was as effective as n-cws for the suppression of growth of such tumors. suppressive effect of n-cws treatme ... | 1979 | 381087 |
| activation of peritoneal macrophages by oil-attached cell-wall skeleton of bcg and nocardia rubra. | the effect of oil-attached cell-wall skeletons of bcg (bcg-cws) and nocardia rubra (n. rubra-cws) on macrophage functions was examined regarding phagocytosis of zymosan particles, uptake of 2-deoxy-d-glucose (2-dg), and cytostatic activity against syngeneic tumor cells. a single intraperitoneal injection of either bcg-cws or n. rubra-cws in mice resulted in accumulation of a large number of macrophages in the peritoneal cavity. they demonstrated, in vitro, a significant cytostatic effect on targ ... | 1979 | 381089 |