| five-member gene family of bartonella quintana. | bartonella quintana, the agent of trench fever and an etiologic agent of bacillary angiomatosis, has an extraordinarily high hemin requirement for growth compared to other bacterial pathogens. we previously identified the major hemin receptor of the pathogen as a 30-kda surface protein, termed hbpa. this report describes four additional homologues that share approximately 48% amino acid sequence identity with hbpa. three of the genes form a paralagous cluster, termed hbpcab, whereas the other me ... | 2003 | 12540561 |
| culture and antibiotic susceptibility of bartonella quintana in human erythrocytes. | bartonella quintana, the agent of trench fever, has recently been implicated in various diseases, in particular, bacteremia and endocarditis in homeless people. the host cell of bartonella spp. is believed to be the erythrocyte, and in the present study we demonstrate that b. quintana can be cultured in vitro in human erythrocytes. the bacteria were found to be intraerythrocytic by laser confocal microscopy with bartonella species-specific monoclonal antibodies. infections with b. quintana decre ... | 2003 | 12543668 |
| bartonella quintana bacteremia and overproduction of interleukin-10: model of bacterial persistence in homeless people. | chronic asymptomatic bacteremia caused by bartonella quintana occurs in homeless people, but its pathophysiology is unknown. we investigated homeless people with bacteremia to determine whether the persistence of b. quintana is associated with a specific immune profile. homeless people without b. quintana infection exhibited an inflammatory profile--levels of circulating markers of leukocyte activation (soluble interleukin [il]-2 receptor and neopterin) and cytokines released by mononuclear cell ... | 2003 | 12599058 |
| [seroprevalence of bartonella henselae and bartonella quintana infections in poland in 1998-2001]. | bartonella henselae and bartonella quintana infections result in illnesses with symptoms of severity ranging from mild lymphadenopathy (csd) to systemic disease. the aim of the study was to estimate a prevalence of b. henselae and b. quintana infections in human in poland. serum samples collected from 265 patients in 1998-2001 were tested for the presence of antibodies specific to b. henselae and b. quintana. levels of serum igm and igg antibodies to bartonella henselae and bartonella quintana w ... | 2002 | 12608089 |
| in vitro bartonella quintana infection modulates the programmed cell death and inflammatory reaction of endothelial cells. | bartonella quintana is an epicellular bacterium, which in vivo as well as in vitro, invades endothelial cells and develops within them inducing proliferative effects that play a pivotal role in neovascular manifestation of this disease. we investigated the effect of live bartonella quintana and its lps on apoptosis and inflammatory response in huvec-c, an endothelial cell line. the kinetics of the programmed cell death of bartonella quintana-infected huvec-c showed a peculiar course. even if ear ... | 2003 | 12614981 |
| molecular detection of bartonella quintana, b. koehlerae, b. henselae, b. clarridgeiae, rickettsia felis, and wolbachia pipientis in cat fleas, france. | the prevalences of bartonella, rickettsia, and wolbachia were investigated in 309 cat fleas from france by polymerase chain reaction (pcr) assay and sequencing with primers derived from the glta gene for rickettsia, the its and pap31 genes for bartonella, and the 16s rrna gene for anaplasmataceae. positive pcr results were confirmed by using the lightcycler and specific primers for the rompb of rickettsia and glta of bartonella. r. felis was detected in 25 fleas (8.1%), w. pipientis, an insect s ... | 2003 | 12643829 |
| urban zoonoses caused by bartonella, coxiella, ehrlichia, and rickettsia species. | the last half of the 20th century witnessed an increase in the occurrence and recognition of urban zoonoses caused by members of the genera bartonella, coxiella, ehrlichia, and rickettsia, all traditionally considered to be members of the family rickettsiaceae. in recent years, new human pathogens (bartonella elizabethae, bartonella henselae, and rickettsia felis) have been recognized in urban environments. other newly recognized pathogens (ehrlichia chaffeensis and ehrlichia phagocytophila in t ... | 2001 | 12653141 |
| chlamydia pneumoniae, but not bartonella quintana, is associated with coronary heart disease: results of a french case-control study. | serologic cross-reactivity has been demonstrated between bartonella quintana and chlamydia pneumoniae. therefore, the association between antibodies to c. pneumoniae and coronary heart disease (chd) as described in the literature may be due to antibodies cross-reacting with b. quintana. to investigate this hypothesis, we evaluated, in a case-control study, the prevalence of c. pneumoniae and b. quintana antibodies among 296 cases with angiographically significant artery lesions and 170 controls ... | 2003 | 12667243 |
| urban trench fever and cat scratch disease. | | 2003 | 12684929 |
| detection and characterization of feline bartonella henselae in the czech republic. | the aims of the study were to characterize isolates of bartonella henselae and to determine the prevalence of bacteremic domestic cats in urban and suburban parts of prague, czech republic. five (18%) gram-negative fastidious bacterial single-cat isolates were recovered from 27 hemocultures incubated without previous freezing. four of these isolates originated from flea infested stray cats (n=6) and one from a shelter cat without any ectoparasites (n=21). none of the 34 previously frozen specime ... | 2003 | 12695049 |
| [extraction and characterization of the lipopolysaccharide of bartonella quintana] | bartonella quintana has been reported as the cause of trench fever, persistent endocarditis, bacteriaemia and has been isolated with an increasing incidence in clinical specimens from aids patients. one of the main pathogenic factors of gram-negative bacteria, including b. quintana, is the lipopolysaccharide (lps). however, very little information is available on the features of bartonella lps. the aim of the present study was to extract, purify and characterise b. quintana lps. the effect of th ... | 1999 | 12759589 |
| bartonella quintana lipopolysaccharide effects on leukocytes, cxc chemokines and apoptosis: a study on the human whole blood and a rat model. | bartonella quintana, an emerging gram-negative pathogen, may cause trench fever, endocarditis, cerebral abscess and bacillary angiomatosis usually with the absence of septic shock in humans. b. quintana lipopolysaccharide (lps), a deep rough endotoxin with strong reactivity in the limulus amebocyte lysate (lal)-assay, was studied in human whole blood and in a rat model. a significant (p<0.05) increase of interleukin-8 (il-8) concentration, comparable to the level induced by enterobacterial lps, ... | 2003 | 12781702 |
| bartonella quintana and mycobacterium tuberculosis coinfection in an hiv-infected patient with lymphadenitis. | cat scratch disease (csd) is usually associated with bartonella henselae infection in patients with a history of cat exposure, but bartonella quintana may also be a cause of chronic lympadenopathy in patients with cat or flea contact. the lymph node histopathology of csd and tuberculosis may be indistinguishable. we report herein the first description of lymph node coinfection with b. quintana and m. tuberculosis in a 32-year hiv-infected woman. culture of lymph node biopsy material on columbia ... | 2003 | 12799150 |
| occurrence of bartonella henselae and bartonella quintana in a healthy greek population. | the purpose of this study was to determine the prevalence of igm and igg antibodies against bartonella henselae and b. quintana in a healthy greek population using a commercially available immunofluorescent test (focus test). five hundred healthy individuals were divided by sex into four age groups and three groups according to contact with cats. igm antibodies were not detected in any of the subjects examined, while 99 (19.8%) and 75 (15%) were igg seropositive to b. henselae and to b. quintana ... | 2003 | 12812344 |
| randomized open trial of gentamicin and doxycycline for eradication of bartonella quintana from blood in patients with chronic bacteremia. | chronic bartonella quintana bacteremia is known to occur in homeless people exposed to lice. we present here the results of an open randomized trial performed to evaluate the efficacy of doxycycline in combination with gentamicin in the eradication of b. quintana bacteremia. from 1 january 2001 to 1 april 2002, homeless people with blood cultures positive for b. quintana were randomized to receive either no treatment (untreated controls) or a combination of gentamicin (3 mg/kg of body weight/day ... | 2003 | 12821469 |
| real-time pcr duplex assay for rickettsia prowazekii and borrelia recurrentis. | rickettsia prowazekii, the etiologic agent for epidemic typhus, and borrelia recurrentis, the etiologic agent of relapsing fever, both utilize the same vector, the human body louse (pediculus humanus), to transmit human disease. we have developed an assay to detect both bacterial pathogens in a single tube utilizing real-time pcr. assays for both agents are specific. the r. prowazekii and b. recurrentis assays do not detect nucleic acid from r. typhi, r. canada, or any of eight spotted fever ric ... | 2003 | 12860643 |
| seroprevalence of bartonella henselae and bartonella quintana infections in poland in 1998-2001. | | 2003 | 12860664 |
| erythroblast cells as a target for bartonella quintana in homeless people. | | 2003 | 12860677 |
| experimental infection of human erythrocytes from alcoholic patients with bartonella quintana. | bartonella spp. are found in the erythrocytes of their specific natural hosts and b. quintana bacteremia is associated epidemiologically with lice, alcoholism, and homelessness. the aim of our study was to compare the growth and the number of bacteria per erythrocyte in vitro in laboratory-infected red blood cells from alcoholic patients versus normal blood donor erythrocytes. enumeration of bacteria was performed either with plate counting or with a real-time pcr quantitative assay. number of b ... | 2003 | 12860697 |
| characterization of new members of the group 3 outer membrane protein family of brucella spp. | impairment of the omp25 gene in brucella spp. leads to attenuated strains and confers protection to the host. omp25 and omp31, whose functions remain unknown, were the first characterized members of group 3 outer membrane proteins (omps) (25 to 34 kda). recently, genomic and proteomic approaches identified five new putative members of this family, some of which are produced in b. melitensis or b. abortus. in the present study, using protein microsequencing, we identified new members of group 3 o ... | 2003 | 12874309 |
| molecular characterization of the sucb gene encoding the immunogenic dihydrolipoamide succinyltransferase protein of bartonella vinsonii subsp. berkhoffii and bartonella quintana. | members of the genus bartonella have historically been connected with human disease, such as cat scratch disease, trench fever, and carrion's disease, and recently have been recognized as emerging pathogens causing other clinical manifestations in humans. however, because little is known about the antigens that elicit antibody production in response to bartonella infections, this project was undertaken to identify and molecularly characterize these immunogens. immunologic screening of a bartonel ... | 2003 | 12874367 |
| upper gastrointestinal bacillary angiomatosis causing hematemesis: a case report. | a 38-year-old hiv-positive woman presented with massive hematemesis on initial admission to hospital. endoscopy revealed ulcerated nodular lesions in the esophagus, stomach, and duodenum. the clinical impression was of kaposi's sarcoma. the stomach was biopsied when the patient re-presented, and another endoscopy was performed. the biopsy showed mucosal ulceration with a proliferation of vascular channels associated with neutrophils and clumps of purplish, granular bacterial colonies, which were ... | 2003 | 12894361 |
| prevalence of bartonella infection among human immunodeficiency virus-infected patients with fever. | bartonella infection can be difficult to diagnose, especially when it manifests as bacteremia, which is usually accompanied by nonspecific symptoms, such as fever. therefore, we hypothesized that bartonella infection represents an underrecognized cause of febrile illness. to determine the prevalence of bartonella infection among patients presenting with fever, we evaluated 382 patients in san francisco. overall, 68 patients (18%) had evidence of bartonella infection detected by culture, indirect ... | 2003 | 12905141 |
| experimental infection of macacus rhesus with rickettsia quintana (trench fever). | | 1953 | 13120859 |
| [presence of rickettsia quintana in pediculus humanus from mexico city; experimental inoculation]. | | 1954 | 13225076 |
| [the presence of rickettsia quintana in the louse pediculus humanus in mexico city; experimental inoculation]. | | 1961 | 13780237 |
| [experimental human rickettsiosis due to rickettsia quintana with ocular manifestations]. | | 1963 | 14026373 |
| [iridocyclitis and focus of retinitis in the course of a therapeutic rickettsiosis with rickettsia quintana]. | | 1963 | 14091833 |
| fine structure of rickettsia quintana cultivated in vitro and in the louse. | ito, susumu (harvard medical school, boston, mass.), and j. w. vinson. fine structure of rickettsia quintana cultivated in vitro and in the louse. j. bacteriol. 89:481-495. 1965.-usually rod-shaped, rickettsia quintana cells measure about 0.2 to 0.5 mu wide and up to 1.6 mu long. the rickettsiae have both an outer cell wall, about 80 a thick, and a plasma membrane, about 70 a thick, each of which is trilaminar. occasional vesicular invaginations of the plasma membrane occur. the nuclear material ... | 1965 | 14255718 |
| [characteristics and systematic position of the rickettsia quintana with comments on the systematics and nomenclature of rickettsia]. | | 1955 | 14387063 |
| pericardial effusion in a homeless man due to bartonella quintana. | bartonella quintana may cause trench fever, endocarditis, bacillary angiomatosis, and chronic bacteremia, and a reemergence among homeless populations in cities has been noted. pericarditis from rickettsia conorii and coxiella burnetii infection has been described, but there have been no reports of pericarditis due to bartonella spp. we report a case of pericardial effusion due to bartonella quintana in a homeless man, diagnosed on the basis of pcr detection of bartonella quintana in a pericardi ... | 2003 | 14605187 |
| an unusual case of cat-scratch disease from bartonella quintana mimicking inflammatory breast cancer in a 50-year-old woman. | cat-scratch disease of the breast has been previously reported. this report describes a very unusual case of cat-scratch disease of the breast caused by bartonella quintana in which the clinical and radiographic presentation mimicked that of inflammatory breast cancer. | 2003 | 14616946 |
| from trench fever to endocarditis. | the case of a 44 year old woman with infective endocarditis due to bartonella quintana, an organism long recognised to cause a condition known as trench fever, is reported. this case illustrates the lengthy differential diagnosis of "culture negative" endocarditis. in addition the presence of serological cross reactivity of bartonella spp and chlamydia spp demonstrates the potential for misdiagnosis in these circumstances. | 2003 | 14654579 |
| etiologic diagnosis of 204 pericardial effusions. | the etiologic evaluation of pericardial effusion is frequently unsuccessful when noninvasive methods are used. to determine the cause of the current episode, all patients with echographically identified pericardial effusion from may 1998 to december 2002 underwent noninvasive diagnostic testing of blood, throat, and stool samples. patients with postpericardiotomy syndrome were excluded. to analyze the value of our tests, we tested randomly selected blood donors as negative controls. among 204 in ... | 2003 | 14663288 |
| causes of febrile illnesses after a tick bite in slovenian children. | to establish the etiology in slovenian children with febrile illnesses occurring after a tick bite. | 2003 | 14688569 |
| comparative molecular and microbiologic diagnosis of bacterial endocarditis. | sequencing of 16s rdna, and of sodaint and rpobint in some cases, was applied to dna from heart valves of 46 patients (36 with definite and 10 with possible endocarditis). sequence-based identifications were compared with those obtained with conventional methods. among the 36 definite cases, 30 had positive blood cultures and 6 had negative cultures. among the 30 positive cases, sequencing of 16s rdna permitted identification of species (18), genus (8), or neither (4); sodaint and rpobint sequen ... | 2003 | 14720393 |
| [attempts of artificial infection of the swine louse haematopinus suis l. with rickettsia prowazeki and rickettsia quintana]. | | 1952 | 14950154 |
| [experimental infection of phthirus pubis l. with rickettsia prowazeki and rickettsia quintana]. | | 1952 | 14951680 |
| [cutaneous infections in the homeless]. | | 2003 | 15008208 |
| clinical problem-solving. index of suspicion. | | 2004 | 15128900 |
| predominant outer membrane antigens of bartonella henselae. | a hallmark of bartonella henselae is persistent bacteremia in cats despite the presence of a vigorous host immune response. to understand better the long-term survival of b. henselae in cats, we examined the feline humoral immune response to b. henselae outer membrane (om) proteins in naturally and experimentally infected cats. initially, a panel of sera (n = 42) collected throughout north america from naturally infected cats was used to probe b. henselae total membranes to detect commonly recog ... | 2004 | 15155610 |
| the louse-borne human pathogen bartonella quintana is a genomic derivative of the zoonotic agent bartonella henselae. | we present the complete genomes of two human pathogens, bartonella quintana (1,581,384 bp) and bartonella henselae (1,931,047 bp). the two pathogens maintain several similarities in being transmitted by insect vectors, using mammalian reservoirs, infecting similar cell types (endothelial cells and erythrocytes) and causing vasculoproliferative changes in immunocompromised hosts. a primary difference between the two pathogens is their reservoir ecology. whereas b. quintana is a specialist, using ... | 2004 | 15210978 |
| seroprevalence of and risk factors for bartonella henselae and bartonella quintana infections among pet cats in jordan. | to determine the seroprevalences of bartonella henselae and bartonella quintana antibodies in jordanian pet cats, serum samples from 153 cats from three geographical regions were analyzed. seroprevalences were determined by indirect immunofluorescence. the true seroprevalences to b. henselae and b. quintana were 32 and 1.5%, respectively. the seroprevalence of b. henselae-specific antibodies in cats from northern jordan was significantly higher than in cats from the central or southern parts of ... | 2004 | 15219970 |
| genomes beyond compare. | | 2004 | 15303267 |
| genome update: promoter profiles. | | 2004 | 15347738 |
| a family of variably expressed outer-membrane proteins (vomp) mediates adhesion and autoaggregation in bartonella quintana. | bartonella species are fastidious, gram-negative human pathogens that can persist in the host bloodstream for years and bind to and invade several types of host cells. for many pathogens, adhesion to host cells and extracellular matrix (ecm) components is a critical virulence determinant. bacteria often vary expression of surface adhesins by phase or antigenic variation to subvert the host immune response and permit adaptive interaction with different host structures. we developed a macaque anim ... | 2004 | 15347808 |
| liver and spleen abscesses without endocarditis due to bartonella quintana in an immunocompetent host. | | 2004 | 15365873 |
| low seroprevalence of bartonella species in danish elite orienteers. | in the 1990s, studies were conducted to investigate 16 episodes of sudden unexpected cardiac death (sucd) among swedish elite orienteers during the period from 1979 to 1992. a case control study revealed that a significantly higher proportion of swedish elite orienteers were b. elizabethae seropositive compared to controls. the aim of our study, designed as a case-control study, was to determine whether similarly high rates of b. elizabethae seropositivity were present among danish elite oriente ... | 2004 | 15370673 |
| detection of bartonella quintana by direct immunofluorescence examination of blood smears of a patient with acute trench fever. | we report a case of bartonella quintana acute symptomatic infection in a homeless man, presenting as a typical trench fever. b. quintana has been retrieved in erythrocytes in large clusters and in erythroblasts. direct immunofluorescence of blood smears allows a rapid diagnosis. | 2004 | 15472378 |
| acinetobacter baumannii in human body louse. | while we were isolating bartonella quintana from body lice, 40 acinetobacter baumannii strains were also isolated and genotyped. one clone was unique and the other was ampicillin susceptible. a. baumannii dna was later detected in 21% of 622 lice collected worldwide. these findings show an a. baumannii epidemic in human body lice. | 2004 | 15498175 |
| bartonella quintana-induced apoptosis inhibition of human endothelial cells is associated with p38 and sapk/jnk modulation and with stimulation of mitosis. | previous studies demonstrated that live bartonella quintana often induces angioproliferative lesions in humans. it modulates endothelial cell apoptotic and inflammatory patterns, thus inducing a very early overexpression of caspase 8 and apaf-1 and increasing mrna production of tnf-alpha, interleukin-8, and e-selectin. however, starting at 10 hours postinfection, the bacteria provoke antiapoptotic effects that induce an increase of bcl-2 gene transcription. to gain further insight into the cellu ... | 2004 | 15541600 |
| molecular detection of bartonella quintana dna in the dental pulp of a homeless patient. | dental pulp has been proposed as a suitable tissue sample for the identification of pathogenic organisms. using pcr with two specific gene targets, bartonella quintana dna was detected in the dental pulp extracted from the tooth of a homeless patient. the patient had been bacteremic 6 months previously but was not when the tooth was sampled. | 2004 | 15558347 |
| seroprevalence of bartonella henselae and bartonella quintana infections in children from central and northern jordan. | to investigate the prevalence of antibodies to bartonella henselae (b.henselae) and bartonella quintana (b.quintana) among children from central and northern jordan. | 2004 | 15573198 |
| multispacer typing technique for sequence-based typing of bartonella quintana. | bartonella quintana is a worldwide fastidious bacterium of the alphaproteobacteria responsible for bacillary angiomatosis, trench fever, chronic lymphadenopathy, and culture-negative endocarditis. the recent genome sequencing of a b. quintana isolate allowed us to propose a genome-wide sequence-based typing method. to ensure sequence discrimination based on highly polymorphic areas, we amplified and sequenced 34 spacers in a large collection of b. quintana isolates. six of these exhibited polymo ... | 2005 | 15634949 |
| ectoparasitism and vector-borne diseases in 930 homeless people from marseilles. | homeless people are particularly exposed to ectoparasites, but their exposure to arthropod-borne diseases has not been evaluated systematically. a medical team of 27 persons (7 nurses, 6 infectious disease residents or fellows, 2 dermatologists, and 12 infectious disease specialists) visited the 2 shelters in marseilles, france, for 4 consecutive years. homeless volunteers were interviewed, examined, and received care; and blood was sampled for cell counts and detection of bacteremia, antibodies ... | 2005 | 15643300 |
| bartonella quintana in a 4000-year-old human tooth. | bacteria of the genus bartonella are transmitted by ectoparasites (lice, fleas, ticks) and have mammalian reservoirs in which they cause chronic, asymptomatic bacteremia. humans are the reservoir of b. quintana, the louse-borne agent of trench fever. we detected dna of b. quintana in the dental pulp of a person who died 4000 years ago. | 2005 | 15655785 |
| serological diagnosis of human babesiosis by igg enzyme-linked immunosorbent assay. | an enzyme-linked immunosorbent assay (elisa) for the detection of igg antibodies to babesia microti antigen was developed. b. microti antigens were harvested from experimentally infected hamster blood and used as a coating antigen. the sensitivity and specificity of the igg elisa relative to immunofluorescent antibody assay (ifa) testing was 95.5% and 94.1%, respectively. according to the receiver operating characteristic curve analysis, the area under the curve was 0.987. no cross-reactivity of ... | 2004 | 15696612 |
| bacterial zoonoses and infective endocarditis, algeria. | blood culture-negative endocarditis is common in algeria. we describe the etiology of infective endocarditis in this country. samples from 110 cases in 108 patients were collected in algiers. blood cultures were performed in algeria. serologic and molecular analysis of valves was performed in france. infective endocarditis was classified as definite in 77 cases and possible in 33. causative agents were detected by blood cultures in 48 cases. all 62 blood culture-negative endocarditis cases were ... | 2005 | 15752438 |
| impact of a molecular approach to improve the microbiological diagnosis of infective heart valve endocarditis. | even today, infective endocarditis (ie) remains a severe and potentially fatal disease demanding sophisticated diagnostic strategies for detection of the causative microorganisms. despite the use of appropriate laboratory techniques, classic microbiological diagnostics are characterized by a high rate of negative results. | 2005 | 15753218 |
| the bartonella vinsonii subsp. arupensis immunodominant surface antigen brpa gene, encoding a 382-kilodalton protein composed of repetitive sequences, is a member of a multigene family conserved among bartonella species. | bartonella proteins that elicit an antibody response during an infection are poorly defined; therefore, to characterize antigens recognized by the host, a bartonella genomic expression library was screened with serum from an infected mouse. this process led to the discovery of a bartonella vinsonii subsp. arupensis gene encoding a 382-kda protein, part of a gene family encoding large proteins, each containing multiple regions of repetitive segments. the genes were termed brpa to -c (bartonella r ... | 2005 | 15845521 |
| high prevalence of bartonella quintana endocarditis in sfax, tunisia. | bartonella quintana is a fastidious microorganism associated with blood culture negative endocarditis. in this study, 40 sera with cross-reactivity between chlamydia species from patients from sfax, tunisia, were serologically tested for bartonella. thirteen sera were positive for bartonella with igg titers >/=1:800. western blot and cross-absorption confirmed the diagnosis of bartonella quintana endocarditis in 12 cases and bartonella henselae endocarditis in 1 case. these sera were also positi ... | 2005 | 15891120 |
| autochthonous epidemic typhus associated with bartonella quintana bacteremia in a homeless person. | trench fever, a louse-borne disease caused by bartonella quintana, is reemerging in homeless persons. epidemic typhus is another life-threatening louse-borne disease caused by rickettsia prowazekii and known to occur in conditions of war, famine, refugee camps, cold weather, poverty, or lapses in public health. we report the first case of seroconversion to r. prowazekii in a homeless person of marseilles, france. this was associated with b. quintana bacteremia. although no outbreaks of typhus ha ... | 2005 | 15891141 |
| [lice and lice-borne diseases in humans]. | among the three lice which parasite the human being, the human body louse, pediculus humanus humanus, is a vector of infectious diseases. it lives and multiplies in clothes and human infestation is associated with cold weather and a lack of hygiene. three pathogenic bacteria are transmitted by the body louse: 1) rickettsia prowazekii, the agent of epidemic typhus of which the most recent outbreak (and the largest since world war ii) was observed during the civil war in burundi; 2) borrelia recur ... | 2005 | 15903070 |
| signature proteins that are distinctive of alpha proteobacteria. | the alpha (alpha) proteobacteria, a very large and diverse group, are presently characterized solely on the basis of 16s rrna trees, with no known molecular characteristic that is unique to this group. the genomes of three alpha-proteobacteria, rickettsia prowazekii (rp), caulobacter crescentus (cc) and bartonella quintana (bq), were analyzed in order to search for proteins that are unique to this group. | 2005 | 15960851 |
| survey of tickborne infections in denmark. | we conducted a study of the distribution and prevalence of tickborne infections in denmark by using roe deer as sentinels. blood samples from 237 roe deer were collected during the 2002-2003 hunting season. overall, 36.6% of deer were borrelia seropositive, while 95.6% were anaplasma phagocytophilum positive; all animals were negative for bartonella quintana and b. henselae by indirect immunofluorescence assay. when a hemagglutination-inhibition test was used, 8.7% of deer were found positive fo ... | 2005 | 16022780 |
| bartonella quintana in domestic cat. | we recovered bartonella quintana dna from dental pulp of a domestic cat. this study, the first to detect b. quintana in a nonhuman mammal, changes our understanding of the epidemiology of this infection and proposes that cats may be an emerging source of human infection. | 2005 | 16102321 |
| characterization of the genome composition of bartonella koehlerae by microarray comparative genomic hybridization profiling. | bartonella henselae is present in a wide range of wild and domestic feline hosts and causes cat-scratch disease and bacillary angiomatosis in humans. we have estimated here the gene content of bartonella koehlerae, a novel species isolated from cats that was recently identified as an agent of human endocarditis. the investigation was accomplished by comparative genomic hybridization (cgh) to a microarray constructed from the sequenced 1.93-mb genome of b. henselae. control hybridizations of labe ... | 2005 | 16109957 |
| bartonella quintana endocarditis in east africa. | bartonella quintana endocarditis is characterized by sub-acute evolution and severe valvular damage, and is associated with homelessness, alcoholism, and lice infestation. we present a case of b. quintana endocarditis in an ethiopian immigrant without known risk factors for disease acquisition. this is the first case of b. quintana endocarditis reported from east africa. | 2005 | 16275550 |
| is pyogenic granuloma associated with bartonella infection? | lobular capillary hemangioma and bacillary angiomatosis due to bartonella infection share several clinical and histopathologic characteristics. we sought to determine whether lobular capillary hemangioma is caused by the same agent as bacillary angiomatosis. forty-five pathology specimens with a histologic diagnosis of lobular capillary hemangioma obtained from patients with the same clinical diagnosis were tested by immunohistochemistry and polymerase chain reaction for the presence of dna elem ... | 2005 | 16310070 |
| bartonella quintana and rickettsia felis in gabon. | we detected rickettsia felis dna in ctenocephalides felis and bartonella quintana dna in 3 pulex irritans fleas taken from a pet cercopithecus cephus monkey in gabon, sub-saharan africa. this is the first report of b. quintana in the human flea. | 2005 | 16318727 |
| evidence for louse-transmitted diseases in soldiers of napoleon's grand army in vilnius. | many soldiers in napoleon's grand army died of infectious diseases during its retreat from russia. because soldiers were commonly infested with body lice, it has been speculated that louse-borne infectious diseases, such as epidemic typhus (caused by rickettsia prowazekii), were common. | 2006 | 16323139 |
| aortic valve endocarditis with bartonella quintana - a rare entity. | endocarditis caused by bartonella species is difficult to diagnose and still remains a rare entity. therefore, a young male patient undergoing aortic valve replacement for culture-negative endocarditis is reported in whom the diagnosis of a bartonella quintana infection was made with a great delay postoperatively. | 2005 | 16331372 |
| [detection of the bartonella dna by the method of nested pcr in patients after tick bites in novosibirsk region]. | arthropod-borne bacterial pathogen bartonella dna was detected in human blood cells after tick bites in summer 2003 and 2004 in novosibirsk region by nested pcr with primers specific to groel gene of hsp60 protein. comparative assay of 190 p.b. of long pcr fragment revealed that the nucleotide sequences might belong to bartonella henselae and bartonella quintana. | 2005 | 16334219 |
| bartonella quintana endocarditis with positive serology for coxiella burnetii. | both bartonella quintana and coxiella burnetii are known to cause of blood culture negative endocarditis. in such case, the diagnosis is usually established by serology. a case of bartonella quintana endocarditis is described where the serology was falsely positive for coxiella burnetii. this case demonstrates the difficulty in distinguishing these two etiologic agents by routine serologic testing. | 2006 | 16386308 |
| antiangiogenic effect of erythromycin: an in vitro model of bartonella quintana infection. | bartonella quintana, the etiological agent of bacillary angiomatosis (ba), causes endothelial cell proliferation. erythromycin has dramatic effects on ba, and the effects are largely unexplained by the compound's bacteriostatic properties. our aim here was to evaluate the possibility that erythromycin alters angiogenesis. | 2006 | 16388485 |
| transient monoclonal gammopathy in a patient with bartonella quintana endocarditis. | monoclonal gammopathy has been reported rarely in association with infectious diseases. viral infection has been the most frequently reported. we report a case of bartonella quintana endocarditis in a 45-year-old homeless male associated with a monoclonal igg kappa gammopathy. the gammopathy disappeared after 8 months of antibiotics while the bartonella antibody titre was decreasing. this correlation suggests a causative role for b. quintana for the monoclonal gammopathy. to the best of our know ... | 2006 | 16432867 |
| antibodies to rickettsia rickettsii, rickettsia typhi, coxiella burnetii, bartonella henselae, bartonella quintana, and ehrlichia chaffeensis among healthy population in minas gerais, brazil. | rickettsial diseases except those belonging to spotted fever group rickettsioses are poorly studied in south america particularly in brazil where few epidemiological reports have been published. we describe a serosurvey for rickettsia rickettsii, r. typhi, coxiella burnetii, bartonella henselae, b. quintana, and ehrlichia chaffeensis in 437 healthy people from a brazilian rural community. the serum samples were tested by indirected micro-immunoflourescence technique and a cutoff titer of 1:64 wa ... | 2006 | 16444416 |
| bartonella quintana associated neuroretinitis. | we report an observational case of bartonella quintana-associated neuroretinitis. the patient had a positive igm ifa titer for bartonella quintana early in the disease. after treatment, the neuroretinitis and igm resolved. given the patient's history, symptoms, response to treatment, and igm course, we believe his neuroretinitis was secondary to bartonella quintana. | 2006 | 16449005 |
| occurrence of bartonella henselae and bartonella quintana among human immunodeficiency virus-infected patients. | the purpose of this study was to determine the seroprevalence against bartonella henselae and bartonella quintana among a risk group, patients with hiv infection, and to identify the epidemiological factors involved. our data indicate that the prevalence of bartonella infection among hiv-infected patients is much greater than that in the healthy population of the same area and that bartonella infection should be considered in the differential diagnosis for patients with hiv disease. | 2005 | 16481530 |
| bacillary angiomatosis caused by bartonella quintana. | bacillary angiomatosis is a disorder of neovascular proliferation involving skin and lymph nodes of immunosuppressed patients. bartonella henselae or bartonella quintana have been inculpated as causative by direct culture or pcr amplification of dna sequences. here, we report the clinical evolution of a patient infected with human immunodeficiency virus (hiv) whose b. quintana infection was diagnosed by pcr. | 2005 | 16481531 |
| bartonella quintana in cynomolgus monkey (macaca fascicularis). | we identified a bartonella quintana strain by polymerase chain reaction amplification, cloning, and sequencing of dna extracted from lysed erythrocytes and cultured colonies grown from peripheral blood collected from a captive-bred cynomolgus monkey (macaca fascicularis). this report describes naturally acquired b. quintana infection in a nonhuman primate. | 2005 | 16485482 |
| production of recombinant bartonella henselae 17-kda protein for antibody-capture enzyme-linked immunosorbent assay. | the bartonella henselae 17-kda protein was expressed in a prokaryotic expression system as a histidine-tagged fusion protein and was purified. the target gene was cloned into a recombinant expression construct, ptri-17kd. the expressed protein was purified to near homogeneity by a nickel-agarose column chromatography. protein recovery was estimated to be 2.9 mg from 100 ml of bacterial culture. the purified 17-kda protein was recognized by serum from patients infected with b. henselae and barton ... | 2006 | 16490335 |
| bartonella quintana characteristics and clinical management. | bartonella quintana, a pathogen that is restricted to human hosts and louse vectors, was first characterized as the agent of trench fever. the disease was described in 1915 on the basis of natural and experimental infections in soldiers. it is now recognized as a reemerging pathogen among homeless populations in cities in the united states and europe and is responsible for a wide spectrum of conditions, including chronic bacteremia, endocarditis, and bacillary angiomatosis. diagnosis is based on ... | 2006 | 16494745 |
| epidemiological studies on bartonella quintana infections among homeless people in tokyo, japan. | in an epidemiological investigation of trench fever in japan, we compared the seroprevalence of bartonella quintana in homeless people and in the general population. in homeless rescue outreach programs held in tokyo from may 2001 to march 2003, 151 blood samples were taken from non-hospitalized homeless people. the prevalence of igm and igg antibodies against b. quintana in these people was compared with that in 200 healthy blood donors using a commercially available indirect fluorescent antibo ... | 2006 | 16495631 |
| localized bacillary angiomatosis in the oral cavity: observations about a neoplasm with atypical behavior. description of a case and review of the literature. | bacillary angiomatosis is a rather frequent infectious pathology appearing mainly in the skin but can also affect the liver, spleen, heart, bones, lungs, muscles, central nervous system and other organs. the localization of the lesion in the oral cavity is rather rare, as it is evident in the literature. bacillary angiomatosis can be clinically similar to the kaposi's sarcoma and histologically confused with angiosarcoma, epitheloid hemangioma and pyogenic granuloma. a case of bacillary angiomat ... | 2006 | 16495874 |
| first molecular evidence of bartonella quintana in pediculus humanus capitis (phthiraptera: pediculidae), collected from nepalese children. | trench fever is a body louse-borne disease caused by bartonella quintana brenner. the recent status of louse infestation in nepalese children is not well known. we collected head and body lice, pediculus humanus capitis de geer and pediculus humanus humanus l., respectively, from 30 children, including 11 cases of double infestation with both head and body lice. detection of b. quintana in both louse species identified was carried out by polymerase chain reaction (pcr). pcr products with b. quin ... | 2006 | 16506456 |
| brucella outer membrane protein omp31 is a haemin-binding protein. | the expression of haemin-binding proteins (hbps) in the outer membrane is one of the strategies used by gram-negative bacteria to obtain iron from the host. no hbp has been described in brucella spp. we investigated whether omp31, an outer membrane protein from brucella with homology to hbps from bartonella quintana, is an hbp. soluble recombinant omp31 bound specifically to haemin-agarose, while an unrelated brucella protein (sura) did not. a similar experiment showed that native omp31 found in ... | 2006 | 16517201 |
| molecular detection of bartonella quintana, b. elizabethae, b. koehlerae, b. doshiae, b. taylorii, and rickettsia felis in rodent fleas collected in kabul, afghanistan. | the prevalences of bartonella spp. and rickettsia spp. were investigated using molecular methods in 77 rodent fleas collected in november 2002 by the french forces detachment in kabul, afghanistan. overall, bartonella dna was detected in 15.5% of gerbil fleas and 40.5% of rat fleas, whereas rickettsia felis was found in 9% of gerbil fleas. we described for the first time in this country bartonella quintana, b. koehlerae, b. taylorii, and rickettsia felis in fleas from the gerbil species meriones ... | 2006 | 16525103 |
| metabolic activity of the trench fever rickettsia, rickettsia quintana. | a study of the metabolic activity of rickettsia quintana was carried out by conventional warburg and radioisotope techniques with intact cells harvested while growing in the fluid counterpart of the medium of vinson and fuller. like other rickettsiae, r. quintana did not utilize glucose, but did metabolize glutamate and glutamine. unlike typhus rickettsiae, r. quintana did not require a diluent high in k(+) for metabolic activity, and it utilized glutamine more efficiently than glutamate. in typ ... | 1967 | 16562152 |
| experimental infection of human body lice with acinetobacter baumannii. | the human body louse is currently recognized as a vector of rickettsia prowazekii, borrelia recurrentis, and bartonella quintana. previous studies have reported the isolation of acinetobacter baumannii from the body lice of homeless patients. to study how the body louse acquires a. baumannii, we infected a rabbit by infusing 2 x 10(6) colony-forming units of the louse strain of a. baumannii. two hundred body lice were infected by feeding on the bacteremic rabbit and compared with 200 uninfected ... | 2006 | 16606978 |
| environmental signals generate a differential and coordinated expression of the heme receptor gene family of bartonella quintana. | of all bacteria, bartonella quintana has the highest reported in vitro hemin requirement, yet an explanation for this remains elusive. to produce diseases such as trench fever, endocarditis, and bacillary angiomatosis, b. quintana must survive and replicate in the disparate environments of the pediculus humanus corporis (body louse) gut and the human vasculature. we previously identified a five-member family of hemin binding proteins (hbps) synthesized by b. quintana that bind hemin on the outer ... | 2006 | 16714552 |
| bartonella quintana coinfection with mycobacterium avium complex and cmv in an aids patient: case presentation. | as a greater number of hiv-infected patients survive despite profound immunodepression due to medical progress, we face complex infection with multiple agents in aids-patients. | 2006 | 16732891 |
| aetiological diagnosis of infective endocarditis by direct amplification of rrna genes from surgically removed valve tissue. an 11-year experience in a finnish teaching hospital. | the aetiology of infective endocarditis (ie) can be determined directly from surgically removed valve tissue using broad-range bacterial rdna polymerase chain reaction (pcr) followed by sequencing. we sought to assess the value of this methodology in a routine clinical setting. | 2006 | 16754257 |
| multispacer typing to study the genotypic distribution of bartonella henselae populations. | bartonella henselae, a worldwide fastidious bacterium, has a feline reservoir and is pathogenic for humans. however, the relationship between human and cat isolates of b. henselae, as well as its population dynamics and geographic heterogeneity, is not fully understood, in part because of the absence of appropriate typing methods. multilocus sequence typing (mlst), the most discriminatory genotyping method for b. henselae, identified seven genotypes and suggested that human isolates arose from a ... | 2006 | 16825371 |
| bartonella quintana variably expressed outer membrane proteins mediate vascular endothelial growth factor secretion but not host cell adherence. | bartonella quintana causes trench fever, endocarditis, and the vasculoproliferative disorders bacillary angiomatosis and peliosis hepatis in humans. little is known about the interaction of this pathogen with host cells. we attempted to elucidate the interaction of b. quintana with human macrophages (thp-1) and epithelial cells (hela 229). remarkably, only b. quintana strain jk-31 induced secretion of vascular endothelial growth factor (vegf) from thp-1 and hela 229 cells upon infection similar ... | 2006 | 16926391 |
| bartonella quintana prosthetic valve endocarditis detected by blood culture incubation beyond 10 days. | we describe the case of a 45-year-old man with mitral and aortic prosthetic valve replacement who presented with symptoms of subacute bacterial endocarditis. bartonella quintana was grown from blood after prolonged culture. the course of the disease was complicated by splenic infarction, glomerulonephritis resulting in progressive renal insufficiency, and cerebroventricular hemorrhage. notably, cardiac ultrasonography showed no extensive vegetations but a strand-like lesion. culture-positive b. ... | 2006 | 16962956 |
| bartonella quintana, lice, and molecular tools. | | 2006 | 17017209 |
| isolation of bartonella quintana from a woman and a cat following putative bite transmission. | we report here the detection of bartonella quintana, after putative bite transmission, in pre-enrichment blood cultures from a woman and from two feral barn cats. prospective molecular epidemiological studies are necessary to characterize the risk of human bartonella quintana infection following cat bites. | 2007 | 17093037 |
| arthropod-borne diseases in homeless. | homeless people are particularly exposed to ectoparasite. the living conditions and the crowded shelters provide ideal conditions for the spread of lice, fleas, ticks, and mites. body lice have long been recognized as human parasites and although typically prevalent in rural communities in upland areas of countries close to the equator, it is now increasingly encountered in developed countries especially in homeless people or inner city economically deprived population. fleas are widespread but ... | 2006 | 17114713 |
| proteomic and immunoblot analyses of bartonella quintana total membrane proteins identify antigens recognized by sera from infected patients. | bartonella quintana is a fastidious, gram-negative, rod-shaped bacterium that causes prolonged bacteremia in immunocompetent humans and severe infections in immunocompromised individuals. we sought to define the outer membrane subproteome of b. quintana in order to obtain insight into the biology and pathogenesis of this emerging pathogen and to identify the predominant b. quintana antigens targeted by the human immune system during infection. we isolated the total membrane proteins of b. quinta ... | 2007 | 17307937 |