| metronidazole resistance among helicobacter pylori strains in malaysia. | | 1992 | 1590330 |
| role of metronidazole resistance in therapy of helicobacter pylori infections. | susceptibility to metronidazole was determined by disk diffusion tests for 559 strains of helicobacter pylori isolated from patients. the overall metronidazole resistance was 26%. in males metronidazole-resistant strains made 18% of all h. pylori strains, and in females the corresponding figure was 40% (p less than 0.001). mics of metronidazole were determined for h. pylori strains from 86 patients undertaking triple therapy, i.e., treatment with colloidal bismuth subcitrate, amoxicillin, and me ... | 1992 | 1590683 |
| bactericidal activity of antimicrobial agents against slowly growing helicobacter pylori. | the doubling times of bacteria at sites of colonization or infection are considerably longer than those in laboratory culture media, and slow growth reduces the susceptibility of bacteria to antimicrobial agents. helicobacter pylori is susceptible to a wide range of antimicrobial agents in vitro; however, tests for inhibitory activity do not adequately predict which antimicrobial agents will eradicate slowly growing h. pylori from the stomachs of patients. the chemostat can be used to compare th ... | 1992 | 1590687 |
| helicobacter pylori lipopolysaccharide effect on the synthesis and secretion of gastric sulfomucin. | the effect of h. pylori lipopolysaccharide on the synthesis and secretion of sulfated mucin in gastric mucosa was investigated using mucosal segments incubated in the presence of [3h]proline, [3h]glucosamine and [35s]na2so4. the lipopolysaccharide, while showing no discernible effect on the apomucin synthesis was found to inhibit the process of mucin glycosylation and sulfation, which at 100 micrograms/ml lipopolysaccharide reached the optimal inhibition of 65%. the analysis of mucin secretory r ... | 1992 | 1590801 |
| electron microscopic evidence of treponema pallidum and helicobacter pylori in gastric tissue. | | 1992 | 1595613 |
| stability of ph gradients in vivo across the stomach in helicobacter pylori gastritis, dyspepsia, and health. | a layer of water-insoluble mucus gel is secreted by the gastric epithelium, and is believed to form an important barrier to acid injury. it is postulated that helicobacter pylori can alter ph gradients by damaging the mucus layer, but no data on ph gradients in vivo in patients with h. pylori gastritis have been published. we aimed to construct a map of mucus-bicarbonate layer ph gradients in health and disease. fourteen healthy asymptomatic volunteers (mean age, 46 yr) and 14 symptomatic patien ... | 1992 | 1595645 |
| effect of sucralfate on the degradation of human gastric mucus by helicobacter pylori protease and lipases. | among the factors implicated in the weakening of mucus perimeter of gastric mucosal defense is helicobacter pylori, the pathogenic action of which appears to be exerted through the elaborated protease and lipase enzymes. we present evidence that the activities of these enzymes are inhibited by an antiulcer agent, sucralfate. the grown colonies of bacteria were washed with saline, filtered through sterilization filter, and the filtrate used as the enzyme source. in the absence of sucralfate, the ... | 1992 | 1595646 |
| long-term omeprazole monotherapy is ineffective against helicobacter pylori infection. | | 1992 | 1595667 |
| in vitro activity of antifungal azoles against helicobacter pylori. | | 1992 | 1597211 |
| in vitro susceptibility of helicobacter pylori to nitecapone. | | 1992 | 1597212 |
| helicobacter pylori lipopolysaccharide stimulates gastric mucosal pepsinogen secretion. | the effect of helicobacter pylori lipopolysaccharide on guinea pig gastric mucosal pepsinogen secretion has been examined using an ussing chamber technique. luminal addition of h. pylori lipopolysaccharide resulted in a fifty-fold stimulation of pepsinogen secretion compared to a twelve-fold increase with e. coli lipopolysaccharide. electron microscopy showed marked degranulation of zymogen granules but no evidence of chief cell disruption. | 1992 | 1600038 |
| sucralfate diminishes basal acid output without affecting gastrin, h. pylori or gastritis in duodenal ulcer patients. | twelve patients with active duodenal ulcer disease and helicobacter pylori infection were treated with 1 g sucralfate q.d.s. for 1 month. ulcers healed in 8 of the 12 patients without an alteration in the h. pylori-associated antral gastritis. sucralfate produced a significant fall in basal acid output in all the patients, from a median of 4.8 (range 2.1-12.1) to 1.6 (0.4-8) mmol/h, p less than 0.01, whereas peak acid output was unchanged from 41 (21-59) before to 38 (24-55) mmol/h after treatme ... | 1992 | 1600044 |
| review article: the treatment of helicobacter pylori infection. | the discovery of helicobacter pylori has stimulated great interest in its role in gastritis, non-ulcer dyspepsia and peptic ulceration. treatment regimens to eradicate this organism from gastric mucosa have also received considerable attention. current recommendations limit the use of triple drug combinations only to specific patient groups. | 1992 | 1600047 |
| does a previous course of tripotassium dicitrato bismuthate affect the subsequent chances of successful helicobacter pylori eradication? | we have performed a retrospective study of 103 patients with either peptic ulcer or non-ulcer dyspepsia, infected with metronidazole-sensitive strains of helicobacter pylori (h. pylori), who were treated with a combination of tripotassium dicitrato bismuthate and metronidazole for a period of at least two weeks. dual therapy with tripotassium dicitrato bismuthate plus metronidazole showed similarly high eradication rates (greater than or equal to 80%) of h. pylori from patients irrespective of a ... | 1992 | 1600049 |
| short report: twenty-four-hour hyperpepsinogenaemia in helicobacter pylori-positive subjects is abolished by eradication of the infection. | twenty-four-hour plasma pepsinogen i and ii concentrations were determined in 8 healthy subjects with antibody to helicobacter pylori, before and after treatment with tripotassium dicitrato bismuthate, amoxycillin and metronidazole, therapy was successful in the 5 subjects with active h. pylori infection. in these subjects, median integrated 24-h plasma pepsinogen i and ii concentrations significantly decreased from 2288 and 357 micrograms.h/l before treatment, respectively, to 1811 and 171 micr ... | 1992 | 1600055 |
| detection of helicobacter pylori-like organisms in the stomach of some food-source animals using a monoclonal antibody. | to investigate a possible animal reservoir of helicobacter pylori, 15 pigs, 15 rabbits and 5 cows slaughtered for consumption were studied. raised serum igg levels were found in 93% of the pigs and 87% of the rabbits, but levels were normal in the cattle. in the controlled testings three of 22 humans had elevated igg to h pylori and in all three h pylori was detected by the use of monoclonal antibody. helicobacter pylori were identified in gastric brushings by a monoclonal antibody in 8 out of 1 ... | 1992 | 1600192 |
| seroepidemiology of helicobacter pylori infection in vegans and meat-eaters. | an enzyme-linked immunosorbent assay has been used to diagnose serologically the prevalence of helicobacter pylori infection in asian life-long vegans. there was no difference in the seropositivity between these individuals and a group of age- and sex-matched asian meat-eaters, indicating the meat consumption is not a risk factor for h. pylori infection. however, both asian groups had a higher prevalence of infection than age- and sex-matched caucasian meat-eaters. additionally, the asian indivi ... | 1992 | 1601079 |
| adherence of helicobacter pylori to hep-2 cells. | the adherence of 25 strains of helicobacter pylori was evaluated in hep-2 cells. these bacterial isolates, obtained from chilean patients with gastric disorders, were also tested for haemagglutination of human red blood cells. adherence of hep-2 cells was expressed as a common property of all strains, irrespective of whether the cultures were grown on semi-solid or in liquid media. previous reports that haemagglutinating activity was present in cells grown only on semi-solid media were confirmed ... | 1992 | 1602147 |
| helicobacter pyrlori in malawi, central africa. | a total of 160 adult malawians with epigastric pain for longer than 2 weeks was investigated by endoscopy and serologically for evidence of infection with helicobacter pylori. the organism was demonstrated histologically and/or by culture in 141 (88%) patients. with histological means and/or culture as the 'gold standard', the histological technique was 100% sensitive while culture was only 81% sensitive. all isolates tested were sensitive to amoxycillin and tetracycline; 74% were resistant to m ... | 1992 | 1602148 |
| helicobacter pylori and non-ulcer dyspepsia in zambia. | | 1992 | 1604727 |
| [evaluation of two commercial kits for detection of helicobacter pylori specific antibodies in patients undergoing gastroscopy. a seroprevalence study in an asymptomatic population]. | we evaluate two different commercially available kits for detecting specific antibodies against helicobacter pylori in a group of 48 patients with gastrointestinal symptoms that underwent an endoscopic procedure. we also study the seroprevalence of anti-h. pylori antibodies in asimptomatic individuals from our area. | 1992 | 1606220 |
| is helicobacter pylori the cause of dyspepsia? | to determine the association between infection with helicobacter pylori and dyspepsia. | 1992 | 1606428 |
| symptoms, gastritis, and helicobacter pylori in patients referred for endoscopy. | acute helicobacter pylori infection is associated with dyspeptic symptoms but chronic infection has not clearly been shown to cause symptoms. to define further the role of h. pylori infection and gastritis in dyspepsia, we interviewed all patients about to undergo upper endoscopy, recorded the primary indication for endoscopy, noted the endoscopic findings, and obtained antral biopsies. among non-ulcer patients there was a strong correlation of acute gastritis with h. pylori. gastritis and h. py ... | 1992 | 1607089 |
| epidemiology of helicobacter pylori in southern china: identification of early childhood as the critical period for acquisition. | a large cross-sectional study to investigate the prevalence and possible modes of transmission of helicobacter pylori was done in southern china. serum samples (1727) were collected from guangzhou city and three rural areas of guangdong province, and the prevalence of h. pylori infection was determined using an elisa. each subject completed a questionnaire. the overall prevalence of h. pylori infection was 44.2%; a significantly higher prevalence was found in guangzhou (52.4%) than in the rural ... | 1992 | 1607687 |
| [studying the role of helicobacter pylori infection in recurrent abdominal pain in children]. | the authors studied the role of helicobacter pylori at recurrent abdominal pain in childhood. helicobacter pylori infection hasn't been found at the 42 examined children. the endoscopy showed esophagitis in 34 cases. the quick urease test, the histological examination, and the bacterial culture are proposed to carry out in ulcus duodeni, gastritis typ. b ulcus ventriculi and not necessary to carry out if the endoscopy shows only esophagitis--emphasize the authors. | 1992 | 1608607 |
| helicobacter colonization and histopathological profile of chronic gastritis in patients with or without dyspepsia, mucosal erosion and peptic ulcer: a morphological approach to the study of ulcerogenesis in man. | helicobacter pylori colonization and the incidence, severity, activity and topography of gastritis were investigated systematically in antrum and corpus mucosal biopsies of 1177 subjects undergoing endoscopy in the absence of gastric complaints (asymptomatic, 49) or for non-ulcer dyspepsia (nud; 631 patients, 72 of whom had gastric and/or duodenal erosions), active gastric ulcer (gu, 76 patients), active duodenal ulcer (du, 138 patients), and healed gastric (hgu, 39 cases) or duodenal ulcer (hdu ... | 1992 | 1609509 |
| helicobacter pylori and peptic ulcer disease. | | 1992 | 1610319 |
| 'gastrospirillum hominis', another gastric spiral bacterium. | 'gastrospirillum hominis' is a 'new' tightly coiled gram-negative bacterium carrying bundles of sheathed polar flagella. it has been rather infrequently detected in antral and, even more rarely, in fundic mucosa samples removed at endoscopy from patients investigated for helicobacter pylori colonization. until now, it has remained noncultivable but has successfully been maintained in laboratory mice. its identity with similar bacteria found in the stomachs of cats, dogs, monkeys, pigs, and other ... | 1992 | 1611710 |
| role of sucralfate in peptic disease. | sucralfate, a basic aluminum salt of sucrose, was the first successful drug with a major cytoprotective mechanism of action. it binds bile acids and pepsin and adheres to both ulcerated and nonulcerated mucosa. sucralfate stimulates the synthesis and release of gastric mucosal prostaglandins as well as bicarbonate and the epidermal growth factor which stimulates healing. sucralfate is the safest drug available today in the treatment of dyspeptic symptoms and compared to ranitidine and cimetidine ... | 1992 | 1611711 |
| [helicobacter pylori: from harmless commensal to clinically significant disease factor]. | | 1992 | 1611970 |
| the importance of determining both urea and ammonium levels in gastric juice for rapid diagnosis of helicobacter pylori infection. | | 1992 | 1612043 |
| helicobacter pylori and non-ulcer dyspepsia. | | 1992 | 1612344 |
| diagnostic efficiency of an ultra-rapid endoscopy room test for helicobacter pylori. | | 1992 | 1612370 |
| subtypes of intestinal metaplasia and helicobacter pylori. | to determine whether there is a relationship between the presence of h pylori and the various subtypes of intestinal metaplasia in the gastric antrum, 2274 antral gastroscopic biopsies from 533 patients were examined. h pylori was found in 289 patients. intestinal metaplasia in general was found in 135 patients. type i intestinal metaplasia was found in 133 patients (98.5%), type ii in 106 patients (78.5%) and type iii in 21 patients (15.6%). ninety eight of these 135 patients (72.6%) were h pyl ... | 1992 | 1612473 |
| suppression of helicobacter pylori reduces gastrin releasing peptide stimulated gastrin release in duodenal ulcer patients. | helicobacter pylori increases gastrin release in duodenal ulcer patients. this may be through disruption or changes in the mucus layer affecting the access of luminal stimulants to gastrin releasing cells. the effect of suppressing h pylori on gastrin release stimulated by a non-luminal stimulus, gastrin releasing peptide (grp), was examined. eleven patients with active duodenal ulcer disease and colonised with h pylori received an intravenous infusion of grp (2.9 pmol/kg/minute for 30 minutes) ... | 1992 | 1612474 |
| ecology of helicobacter pylori in peru: infection rates in coastal, high altitude, and jungle communities. the gastrointestinal physiology working group of the cayetano heredia and the johns hopkins university. | we have examined endoscopic clinic patients in three widely different geographic regions of peru (the coast, the sierra of the andes mountains, and the amazon jungle) for the presence of helicobacter pylori infection associated with active gastritis. the overall rates of infection were high (80% or greater) in all three zones and rates for men were approximately 10% higher than for women in the same zone. men and women in the sierra and jungle areas had significantly higher rates of infection th ... | 1992 | 1612475 |
| purification of recombinant helicobacter pylori urease apoenzyme encoded by urea and ureb. | helicobacter pylori, a gram-negative, microaerophilic, spiral-shaped bacterium, is an etiologic agent of human gastritis and peptic ulceration and is highly restricted to the gastric mucosa of humans. urease, synthesized at up to 6% of the soluble cell protein, hydrolyzes urea, thereby releasing ammonia, which may neutralize acid, allowing survival of the bacterium and initial colonization of the gastric mucosa. the urease protein is encoded by two subunit genes, urea and ureb; however, accessor ... | 1992 | 1612735 |
| hypertrophic gastropathy with transient sessile polyps. | we report an 8-year-old boy with hypertrophic gastropathy (hg) associated with duodenal giardia lamblia infestation. the follow-up was complicated by the development of gastric polyps at the site of previous biopsies that spontaneously disappeared within 15 months. despite the histological similarity, the different course between ménétrier's disease (md) in adults (chronic, with frequent development of sessile or pedunculate polyps) and hg (uncomplicated and usually spontaneously resolving) sugg ... | 1992 | 1619539 |
| protein-losing enteropathy and helicobacter pylori. | | 1992 | 1619544 |
| [peptic acid disease associated with helicobacter pylori in children. report of a case]. | we studied a child with peptic acid disease which was associated with h. pylori. the identification of h. pylori was done by biopsy and for antibody test. clinical improvement was observed only with the use of amoxocilin and bismuth subsalycilate. | 1992 | 1621037 |
| peptic ulcer disease. | peptic ulcer disease affects between 5 percent and 10 percent of americans during their lifetime. there are a variety of predisposing factors, including nonsteroidal anti-inflammatory drug (nsaid) use, helicobacter pylori infection, tobacco use and, possibly, certain dietary practices. while h2-receptor antagonists remain the mainstay of therapy, the selection of an antiulcer drug should be individualized. famotidine is preferred in persons who use alcohol, sucralfate may be preferred for mainte ... | 1992 | 1621633 |
| [development of genetic and molecular approaches for the diagnosis and the study of the pathogenic power of helicobacter pylori, agent of inflammatory gastric diseases]. | helicobacter pylori (h. pylori) is a small gram negative bacillus, recently discovered, found in the stomach of patients with active chronic gastritis and duodenal ulcers. production of a potent urease has been described as a trait common to all h. pylori so far isolated. to clarify the role of urease in the pathogenic process, as well as to engineer genetic tools useful for the diagnosis of h. pylori, we cloned the genes responsible for urease activity. a genomic library was constructed in esch ... | 1992 | 1622109 |
| chemotactic activity of helicobacter pylori sonicate for human polymorphonuclear leucocytes and monocytes. | the immunopathology of helicobacter pylori associated active chronic gastritis, which is characterised by predominance of polymorphonuclear leucocyte infiltration, is largely unknown. to evaluate the role of bacterial components as inflammatory mediators ultracentrifuged sonicated preparations were made of clinical isolates of helicobacter pylori. the crude sonicates were shown to exhibit chemotactic activity for human polymorphonuclear leucocytes and blood monocytes in a concentration dependent ... | 1992 | 1624151 |
| optimal survival of helicobacter pylori under various transport conditions. | the ability of clinical isolates and type strains of helicobacter pylori to survive in stuart transport medium, isotonic saline solution, and urea-containing isotonic saline was evaluated. the influences of temperature (4, 10, 15, 20, and 30 degrees c) and holding time (6 to 48 h) and the effect of exposure to air on survival were also studied. the recovery rate of h. pylori was highest from stuart transport medium in comparison with the recoveries from the other transport media tested. we found ... | 1992 | 1624562 |
| evaluation of the performance of commercial test kits for detection of helicobacter pylori antibodies in serum. | we have compared the sensitivities, specificities, and predictive values of three commercial serological assays for the diagnosis of helicobacter pylori infection. a qualitative latex method (pyloriset; orion diagnostics), a semiquantitative enzyme-linked immunosorbent assay (elisa) (gap test igg; bio-rad), and a quantiative elisa (helico-g; porton cambridge) were used in 109 untreated dyspeptic patients. the presence of h. pylori was established when the results of culture and/or histology of t ... | 1992 | 1624571 |
| expression of hla-dr antigen in different histological types of gastric polyp. | to study the expression of hla-dr antigen in the different histological types of gastric polyps. | 1992 | 1624598 |
| [helicobacter pylori spectrum: from gastritis to malignancy]. | | 1992 | 1625512 |
| [helicobacter pylori colonization of the gastric remnant following partial resection]. | colonization by helicobacter pylori (hp) in 53 patients after remote gastric surgery and roux-en-y anastomosis was investigated using a rapid urease test (cu-test) and histology (h&e and giemsa stain). the ph-value of gastric juice was measured. hp infection of the gastric remnant was found in 56% of 43 patients after partial resection and in no case after total gastric resection. hp-positive and hp-negative patients were comparable in age, sex distribution, indication and technique of gastric o ... | 1992 | 1626250 |
| immunoglobulin g antibodies to helicobacter pylori in patients with dyspeptic symptoms investigated by the western immunoblot technique. | helicobacter pylori is a gram-negative, curved, rod-shaped bacterium known to cause gastritis and to be an important factor in the pathogenesis of peptic ulcers. serological testing has recently been proposed as an aid in diagnosis of h. pylori infections. in this study, we used the western immunoblot technique to evaluate the possibility of using one or more of the antigens from h. pylori for this purpose. thirteen major bands and about 30 minor bands could be identified by western blotting whe ... | 1992 | 1629330 |
| helicobacter pylori has an ulcerogenic action in the ischemic stomach of rats. | helicobacter pylori (h. pylori) is now accepted as an important cause of chronic active gastritis. there also seems to be an association between the colonization of h. pylori in the gastric mucosa and peptic ulceration. however, it has not demonstrated that the instillation of h. pylori into the stomach produces the ulcerative gastric lesions in animals or humans. we carried out an experiment to study whether or not h. pylori has an ulcerogenic action in the ischemic stomach of rats, using an ex ... | 1992 | 1629566 |
| cytopathic effects of helicobacter pylori on cultured mammalian cells. | cytopathic effects of broth-culture filtrates from eight clinical isolates and one reference strain of helicobacter pylori on three cultured mammalian cell lines were investigated. all the strains, including nctc 11637, produced cytotoxic factors that caused intracellular vacuolation on these cell lines. ags and sflep cells were more sensitive than hep-2 cells. to examine the role of urease in the cytotoxic effect, a urease-negative mutant was produced. filtrates from both wild-type and mutant s ... | 1992 | 1629896 |
| motility as a factor in the colonisation of gnotobiotic piglets by helicobacter pylori. | non-motile variants of helicobacter pylori (strain 26695) occurred with a frequency of 1.6 (sd 0.4) x 10(-4) variants/cell/division cycle, and reversion to the motile form occurred with a frequency of less than 10(-7) variants/cell/division cycle. the two forms remained greater than 90% pure for up to 50 cell divisions and differed only in the presence or absence of motility and flagella. bacteria were recovered from nine of 10 gnotobiotic piglets inoculated orally with motile h. pylori, but fro ... | 1992 | 1629897 |
| helicobacter pylori infection in dialyzed patients: bismuth therapy and pharmacokinetics. | | 1992 | 1630551 |
| [stomach ulcer and helicobacter pylori]. | | 1992 | 1632003 |
| [helicobacter pylori]. | helicobacter pylori (hp) are gram-negative spiral bacteria which occur in the human stomach. the bacteria were cultured in vitro for the first time in 1983. it is suspected that the bacteria may cause chronic gastritis of type b and may also be a contributory cause of chronic ulceration and cancer of the stomach. the bacteria are accompanied by characteristic inflammatory changes in the gastric mucosa. the significance for gastritis, chronic ulceration, non-ulcer dyspepsia and carcinoma of the s ... | 1992 | 1632004 |
| inhibition of helicobacter pylori glycosulfatase activity toward gastric sulfomucin by nitecapone. | a glycosulfatase activity toward gastric sulfomucin was identified in the extracellular material elaborated by h. pylori. the enzyme exhibited maximum activity at ph 5.7 in the presence of triton x-100 and cacl2, and displayed on sds-page an apparent molecular weight of 30kda. the h. pylori glycosulfatase effectively caused desulfation of n-acetylglucosamine-6-sulfate and galactose-6-sulfate of the carbohydrate chains of mucins, as well as that of glucose-6-sulfate of glyceroglucolipids, but was ... | 1992 | 1632804 |
| [clinical significance of serological markers of helicobacter pylori]. | helicobacter pylori (h. pylori) is a gram-negative, curved bacillus known since 1983. it is supposed to play role in the pathogenesis of certain gastroduodenic diseases, e.g. non-ulcer dyspepsia (nud), chronic inflammation, ulcers, etc. serum samples of 70 patients who were examined for stomach complaints with gastroscopy and those of 22 healthy persons were analysed. the purpose of the study was to evaluate anti-h. pylori igg, igm and iga antibodies using elisa method. whether the antibodies ca ... | 1992 | 1635774 |
| ebrotidine effect on the proteolytic and lipolytic activities of helicobacter pylori. | 1. the effect of ebrotidine, a new antiulcer agent, on the activity of mucus degrading of protease and lipase enzymes elaborated by helicobacter pylori was investigated. 2. in the absence of ebrotidine, the h. pylori protease caused extensive degradation of gastric mucus protein, while free fatty acids, glycerol mono-oleate and lysophosphatidylcholine were produced by the action of h. pylori lipase and phospholipase a enzymes. 3. introduction of ebrotidine to the incubation system led to the red ... | 1992 | 1639232 |
| eicosanoid synthesis and helicobacter pylori associated gastritis: increase in leukotriene c4 generation associated with h. pylori colonization. | the importance of pro-inflammatory leukotriene c4 in helicobacter pylori (h. pylori) associated gastritis in man is unknown. fresh gastric biopsy specimens from 28 dyspeptic patients were obtained: 10 showed normal antral histology with no evidence of h. pylori, the remaining 18 patients exhibited histological gastritis and were h. pylori positive as assessed by histology, culture and urease test. twelve of these 18 patients received 240 mg twice daily colloidal bismuth subcitrate for four weeks ... | 1992 | 1641505 |
| serodiagnosis of helicobacter pylori-associated gastritis with a monoclonal antibody competitive enzyme-linked immunosorbent assay. | forty-nine monoclonal antibodies against helicobacter pylori were screened to investigate their capacity to be used in enzyme-linked immunosorbent assay (elisa) competitive systems for the serodiagnosis of helicobacter pylori infection. on the basis of the inhibition pattern showed by the sera of five infected patients, the antibodies were subdivided into five groups. the immunoblotting analysis showed that the antibodies recognized a total of nine different antigenic determinants. in a study of ... | 1992 | 1641587 |
| [helicobacter pylori infections in children]. | in our patient population with chronic aspecific abdominal complaints helicobacter pylori gastritis is no rarity. this entity has been diagnosed in 10 children out of 48 (mean age: 8 years 11 months) who underwent an endoscopy of the upper gastrointestinal tract. after treatment with amoxicillin and colloidal bismuth subcitrate during a period of 2 weeks the complaints disappeared and an eradication was obtained in 7. histology of the antral mucosa demonstrated a type b chronic active gastritis ... | 1992 | 1641843 |
| visual endoscopic indicator of helicobacter pylori infection. | | 1992 | 1642216 |
| a prospective randomized study of the injurious effects of aspirin and naproxen on the gastroduodenal mucosa in patients with rheumatoid arthritis. | a prospective double-blind randomized placebo-controlled study was conducted to compare the injurious effects of aspirin and naproxen on the gastroduodenal mucosa. patients with rheumatoid arthritis attending the immunology clinic of a tertiary care center were included in the study. ninety consecutive patients were randomized to receive aspirin, naproxen, or placebo. clinical evaluation was done every 2 wk. upper gastrointestinal endoscopy, biopsies from the gastric antrum and duodenum for hist ... | 1992 | 1642224 |
| helicobacter pylori infection in children. a clinical overview. | | 1992 | 1643767 |
| non-immunological defence mechanisms of the gut. | non-immunological defence mechanisms represent an important line of intestinal defence in addition to humoral and cellular immunity. this review summarises the evidence for the role of the non-immunological defence system. protective factors that have been amply documented are gastric juice, intestinal motility, and intestinal flora. components of pancreatic juice, lysozyme, and epithelial cell turnover may also be involved. special attention is given to gastric acid, infection with helicobacter ... | 1992 | 1644343 |
| [anti-helicobacter pylori drugs must be considered as first line therapy in peptic ulcer]. | | 1991 | 1658869 |
| helicobacter pylori-associated gastritis is rare in aids: antibiotic effect or a consequence of immunodeficiency? | helicobacter pylori is the principal cause of type b histologic gastritis. aids is associated with increased susceptibility to gram-negative enteric infections. using a retrospective study design, we have determined the prevalence of h. pylori-associated histologic gastritis (based on gastric histopathology) in 201 patients with aids. these data were compared with h. pylori prevalence rates (based on serology) from healthy hiv-negative, age-matched australian controls (n = 785) and a cohort (n = ... | 1991 | 1660218 |
| [elisa for detection of anti-urease antibodies of campylobacter pylori and its application]. | the urease extracted from 6 strains of helicobacter pylori (hp) was used as antigen to detect sera anti-urease antibodies of hp in 136 patients with gastric diseases and 13 persons with normal gastric mucosa by enzyme-linked immunosorbent assay (elisa). the antigen proved to be pure and specific for elisa. for a titre of 450eu or over 450eu the test had a sensitivity of 91.96% and a specificity of 86.49%. the results of the elisa showed excellent correlation with microbiological detection of hp ... | 1991 | 1660762 |
| azithromycin levels in plasma and gastric tissue, juice and mucus. | azithromycin is the first member of a new class called the azalides. its distribution in gastric tissues was studied in 27 patients (mean age 66 years) with proven gastric cancer due to be resected. five groups of patients received a single 500 mg oral dose of azithromycin 24, 48, 72, 96 or 120 h pre-operatively. samples of blood, gastric juice, mucus and gastric tissue were taken and azithromycin assayed by high performance liquid chromatography. there was an increase in the level of azithromyc ... | 1991 | 1662634 |
| inhibition of human gastric cyclic amp production by helicobacter pylori protein--possible involvement of mucosal prostaglandin e2. | the effect of helicobacter pylori protein on camp and prostaglandin (pge2) production was studied in incubates of human gastric fundic mucosa. at 24 hours, specimens incubated in the control fluid had a median camp value of 81 pmol/mg protein, compared to 28 pmol/mg (p less than 0.05) when incubated in h. pylori protein, 155 pmol/kg (p less than 0.006) in histamine, and 23 pmol/kg (p less than 0.05) in histamine plus h. pylori protein. a similar trend was observed at 48 hours. although h. pylori ... | 1991 | 1663793 |
| [chronic gastritis and helicobacter pylori infection on the ivory coast. a series of 277 symptomatic patients]. | only a few reports have established the importance of chronic gastritis and helicobacter pylori infection in africa. the aim of this study was to ascertain the prevalence of chronic gastritis and helicobacter pylori infection in a symptomatic population in abidjan, côte-d'ivoire. the study included 277 consecutive patients referred for gastroscopy. two hundred nine patients complained of abdominal pain without gastroduodenal ulcer or cancer: 26 had a duodenal ulcer, 23 had a gastric ulcer, and 6 ... | 1991 | 1667767 |
| [preliminary study of the prevalence of helicobacter pylori in tananarive, madagascar and the antibacterial activity in vitro of 13 malagasy medicinal plants on this germ]. | helicobacter pylori infection has been studied in 60 patients who were suffering from either a peptic ulcer disease or a gastritis complaint. helicobacter pylori was searched in antral biopsy specimens using standard bacteriological methods (gram-staining urea-test, culture) and histological staining techniques (hematoxylin-eosin-saffron, undifferentiated giemsa). the culture was successful in 40 cases. the antibacterial activity of 13 malagasy medicinal plants has been tested versus helicobacte ... | 1991 | 1669364 |
| anti-helicobacter pylori therapy: clearance, elimination, or eradication? | | 1991 | 1671157 |
| follow-up after anti-helicobacter pylori treatment. | | 1991 | 1671932 |
| helicobacter pylori infection in cohabiting children. | | 1991 | 1672930 |
| lack of eradication of helicobacter pylori after omeprazole. | | 1991 | 1673511 |
| [prevention of duodenal ulcer recurrence. a new prospect]. | prevention of recurrence is now the main therapeutic problem in the management of duodenal ulcer disease. it has been shown that in the absence of maintenance treatment the mean recurrence rate within 6 to 12 months from healing obtained with drugs other than h2-receptor antagonists (h2a) is lower than when healing is obtained with h2a. possible reasons for this discrepancy are examined. when the recurrence rates observed with each of the non-h2a drugs were compared individually with those obser ... | 1991 | 1673786 |
| achlorhydria-induced hypergastrinaemia: the role of bacteria. | 1. studies of helicobacter pylori show that microbes can alter gastrin release. lack of gastric acid (achlorhydria) causes hypergastrinaemia and allows bacteria to grow within the stomach. we speculated that the bacteria contribute to the rise in gastrin seen after acid inhibition, and tested the idea by comparing plasma gastrin levels during inhibition of acid secretion between germ-free and conventional rats. 2. matched germ-free and conventional rats (n = 8 per group) received either vehicle ... | 1991 | 1673881 |
| frozen biopsy specimens and culture rates of helicobacter pylori. | | 1991 | 1674782 |
| activity of lansoprazole against helicobacter pylori. | | 1991 | 1675355 |
| water source as risk factor for helicobacter pylori infection in peruvian children. gastrointestinal physiology working group. | helicobacter pylori infection is widespread among peruvian adults by the age of 30, but the age at which children become infected, the prevalence of disease, and the role of socioeconomic status in the epidemiology of infection are not known. we used the 13c-urea breath test to study the prevalence of infection in 407 peruvian children from lima, aged 2 months to 12 years, from families of low and high socioeconomic status. peruvian children acquire h pylori early in life and the number of infec ... | 1991 | 1675369 |
| [clinical course and treatment of duodenal ulcer in women]. | overall 260 women and 202 men were examined comparatively during duodenal ulcer exacerbation. 53.8% of the women demonstrated an atypical disease course. fibrogastroscopy is a method of early diagnosis of duodenal ulcer in women. as compared to men, the size and depth of ulcers in women was less. acid and peptic factor was also less pronounced. the four-week treatment with the use of the diet, antacids, gastrozepine and repair agents brought about ulcer healing in 82% of the women. the single an ... | 1991 | 1675494 |
| duodenal ulcer relapse after eradication of helicobacter pylori. | | 1991 | 1675746 |
| screening dyspepsia by serology to helicobacter pylori. | owing to limited endoscopy resources, various screening strategies for endoscopy have been proposed. helicobacter pylori can be detected with high sensitivity and specificity by serology, and therefore we assessed the effects on diagnostic accuracy and endoscopic workload of a policy of screening clinic patients with dyspepsia before endoscopy by a strategy based on age, helicobacter pylori serology, and use of non-steroidal anti-inflammatory drugs. 1153 patients were studied, of whom 842 were o ... | 1991 | 1676478 |
| much ado about gastrin. | the regulation of gastrin secretion from antral g-cells is of major importance in the physiologic control of acid secretion. gastrin secretion is highly dependent upon gastric intraluminal ph and is inhibited significantly by a ph of less than 3.0. acute gastric alkalinization greater than ph 6.0 with antisecretory agents such as h2-receptor antagonists or h+/k+ atpase inhibitors has little impact on fasting serum gastrin levels but promotes an enhanced sustained rise in meal-stimulated gastrin ... | 1991 | 1676713 |
| isolation of helicobacter pylori from frozen gastric biopsy specimens. | | 1991 | 1676805 |
| an increased number of gamma/delta t-cells and gastric epithelial cell expression of the groel stress-protein homologue in helicobacter pylori-associated chronic gastritis of the antrum. | numerous studies have shown that the presence of helicobacter pylori in the stomach is linked to the development of chronic gastritis most commonly seen in the antrum. however, the pathogenic mechanisms are unclear. in 23 of 31 patients, examined due to symptoms from the upper gastrointestinal tract, h. pylori-associated chronic gastritis of the antrum was diagnosed histologically and by growth of h. pylori. immunoperoxidase staining on gastric biopsy specimens from these patients showed an incr ... | 1991 | 1677527 |
| mucosal iga recognition of helicobacter pylori 120 kda protein, peptic ulceration, and gastric pathology. | the gastric iga response to helicobacter pylori was examined in 100 dyspeptic patients by means of immunoblotting of supernatants from antral biopsy and gastric mononuclear cell cultures. 76 of 78 patients with chronic gastritis, 2 of 8 with reactive gastritis, and 1 of 14 subjects with normal mucosa showed positive responses. of patients with chronic gastritis, 75%, 83%, 97% and 76%, respectively, showed responses to the 120 kda, 90 kda, 61 kda, and 31 kda proteins. none of the 19 patients with ... | 1991 | 1677696 |
| screening for helicobacter pylori in dyspepsia. | | 1991 | 1677739 |
| second annual symposium on helicobacter pylori. cincinnati, ohio, usa, 6 and 7 august 1990. | | 1991 | 1678205 |
| duodenal ulcer recurrence and helicobacter pylori. | | 1991 | 1678818 |
| screening dyspepsia by serology to helicobacter pylori in children. | | 1991 | 1681395 |
| symposium on helicobacter pylori: a cause of gastroduodenal disease. cincinnati, ohio, 9-10 october 1989. | | 1991 | 1681582 |
| screening for helicobacter pylori. | | 1991 | 1682570 |
| helicobacter pylori-associated gastritis and primary b-cell gastric lymphoma. | although lymphoid tissue is absent in normal gastric mucosa, primary lymphomas arise in the stomach and most of these recapitulate the features of mucosa-associated lymphoid tissue (malt). gastric lymphoid tissue is known to be acquired in response to local infection by helicobacter pylori, and we have confirmed this in 450 patients with h pylori-associated gastritis of whom 125 showed mucosal lymphoid follicles. in 8 patients, b lymphocytes infiltrated epithelium, which is a feature characteris ... | 1991 | 1682595 |
| one week eradication regimen for helicobacter pylori. | although helicobacter pylori is both a frequent cause of gastritis and an important factor in duodenal ulcer recurrence, no treatment regimen exists that is completely safe and effective. we have studied a short eradication regimen of tripotassium dicitrato bismuthate 120 mg four times daily and amoxycillin 500 mg four times daily for seven days with metronidazole 400 mg five times daily for three days (days 5-7). 106 patients with peptic ulceration and non-ulcer dyspepsia, who were also infecte ... | 1991 | 1682653 |
| treatment of duodenal ulcer with sucralfate. | sucralfate attains a healing rate of about 79% for duodenal ulcer in 4 weeks, which is similar to the effects of cimetidine and ranitidine. whereas cigarette smoking significantly affects duodenal ulcer healing by acid-reducing agents, the healing rates of smokers and non-smokers treated with sucralfate or colloidal bismuth are indistinguishable, suggesting an inherent advantage through the cytoprotective mechanisms of these agents. the 12-month relapse curves for duodenal ulcers initially heale ... | 1991 | 1683491 |
| helicobacter-associated duodenitis and gastric metaplasia in duodenal ulcer patients. | biopsy specimens were taken from the duodenal bulb and the distal duodenum in 45 duodenal ulcer patients before and after treatment with histamine-2 antagonists, prostaglandin analogues or antacids. after four weeks of treatment, the ulcer had healed in 31 patients. the treatment did not lead to a reduced frequency of helicobacter-associated duodenitis or gastric metaplasia of the duodenal epithelium. we found gastric metaplasia in 52.3% of all biopsy specimens from the duodenal bulb, chronic ac ... | 1991 | 1683540 |
| iv workshop on gastroduodenal pathology and helicobacter pylori. bologna, november 28-30, 1991. abstracts. | | 1991 | 1684305 |
| restriction fragment length polymorphism of helicobacter pylori using the urease gene probe. | | 1991 | 1684943 |